CN114748406B - Skin care lotion capable of relieving and preserving moisture and preparation method thereof - Google Patents
Skin care lotion capable of relieving and preserving moisture and preparation method thereof Download PDFInfo
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- CN114748406B CN114748406B CN202210514552.9A CN202210514552A CN114748406B CN 114748406 B CN114748406 B CN 114748406B CN 202210514552 A CN202210514552 A CN 202210514552A CN 114748406 B CN114748406 B CN 114748406B
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- moisturizing
- skin
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- particles
- lotion
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Classifications
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- A—HUMAN NECESSITIES
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Abstract
The application relates to the field of cosmetics, and particularly discloses a skin care lotion capable of relieving and preserving moisture and a preparation method thereof. The skin-care lotion for relieving and moisturizing comprises the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of glycol and 70-80 parts of water; the humectant comprises hyaluronic acid, magnesium aspartate and panthenol with the mass ratio of (0.3-0.5) to (0.1-0.3). The soothing and moisturizing skin care lotion has the advantages of good moisturizing effect, long-acting water locking, lasting moisturizing effect and sun protection effect.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a soothing and moisturizing lotion and a preparation method thereof.
Background
The skin care lotion can also be made into tightening lotion, softening lotion, refreshing lotion and the like, and has the main functions of helping skin to moisturize, astringe pores and promote skin firmness after face cleaning, and the skin care lotion contains a large amount of nutrient substances, so that abundant nutrition can be provided for skin, moisture and wind of the skin are conditioned, and the skin is moistened to be softer and more glossy. Whether skin moisture is full or not directly influences the external complexion of a person, and a series of skin problems such as skin chapping, wrinkling, molting, allergy and the like can be caused, even the cosmetic effect can be influenced, so that the skin lotion not only meets the psychological requirement of high-end consumption to a great extent, but also is an effective way for consumers to moisturize the skin and supplement the nutrition of the skin.
The existing moisturizing components mainly comprise water solubility, oil solubility and high molecular, but the oil-soluble moisturizing components are difficult to dissolve in water, the skin feel is sticky, the water-soluble moisturizing components are easy to absorb by skin due to small molecular weight, but long-acting moisturizing performance is poor, the high molecular moisturizing components such as sodium hyaluronate mainly play a role in moisturizing, the low molecular weight sodium hyaluronate mainly plays a role in moisturizing, but the sodium hyaluronate with higher molecular weight is sticky in skin feel, and if the skin feel is improved, the amount of medium molecular weight and oligomeric sodium hyaluronate is required to be increased to achieve the effect of refreshing nature, but the production cost is inevitably increased.
In view of the above related art, the inventors have found that there is a need to develop a skin lotion which has a lasting moisturizing effect and is fresh and not sticky.
Disclosure of Invention
In order to improve the long-acting moisturizing effect of the skin care lotion and reduce the sticky feel of the skin care lotion, the application provides a soothing and moisturizing skin care lotion and a preparation method thereof.
In a first aspect, the present application provides a moisturizing lotion, which adopts the following technical scheme:
the skin-care lotion for relieving and moisturizing comprises the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of glycol and 70-80 parts of water;
the humectant comprises hyaluronic acid, magnesium aspartate and panthenol with the mass ratio of (0.3-0.5) to (0.1-0.3).
According to the technical scheme, the purslane extract, the honey extract, the copper gluconate, the zinc gluconate and the like are used for preparing the skin care water, the purslane extract is mild and comfortable, has moisturizing and antioxidation effects, is fresh and cool in texture and good in fluidity, amino acids in the purslane extract can shrink blood vessels, smooth skin, relieve skin and inhibit skin itch caused by dryness, the honey extract has moisturizing and moisturizing effects and long-acting nourishing effects, the moisturizing agent is composed of hyaluronic acid, magnesium aspartate and panthenol, the hyaluronic acid is favorable for moisturizing and keeping elasticity of the skin, can moisturize and lock water, keeps a barrier function, also has the effects of delaying aging, preventing free radical injury, resisting saccharification, the magnesium aspartate has an antioxidation effect, prevents aging, has relatively fresh and non-sticky skin feel, is small in molecule, has good in permeability, has a strong moisturizing effect, the zinc gluconate can inhibit synthesis of free fatty acid, and has the effects of resisting oxidization and inflammation, the hydrolyzed collagen can achieve good glossiness, has good moisturizing and moisturizing effects, a plurality of components, has synergistic effects, can be prepared into skin care skin, and has no sensitive skin irritation.
Optionally, the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3:0.3.
By adopting the technical scheme, the dosage of each component in the humectant is further accurately controlled, so that the moisturizing and water locking effects of the skin care lotion are better and more remarkable.
Optionally, the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of (0.5-1).
By adopting the technical scheme, the addition of the p-hydroxyacetophenone and the 1, 2-hexanediol can prolong the storage life of the skin care water and prevent pollution in the use process.
Optionally, the moisture-relieving skin-care lotion also comprises 0.5-1.5 parts by weight of moisture-preserving particles and 0.1-0.5 part by weight of rheology modifier, wherein the moisture-preserving particles comprise wall materials and core materials in a mass ratio of 1:0.5-0.7;
the wall material comprises the following components in parts by weight: 1-2 parts of soybean protein, 1-2 parts of maltodextrin, 0.5-1 part of lotus stalk extracting solution, 0.5-1 part of sunflower root fermentation product, 0.1-0.15 part of flaxseed gum and 1-1.5 parts of water;
the core material is one or more of vegetable oil, animal oil and mineral oil.
In order to further improve the deep water locking effect of the skin care water, the effect is generally achieved by improving the grease content in a skin care water system, but the increase of the grease content inevitably improves the viscosity of the skin care water, so that the skin care water is sticky and thick, the skin feel is reduced, by adopting the technical scheme, a film with a porous structure is formed by taking soybean protein and maltodextrin as wall materials, and a flaxseed gum is taken as an emulsifying agent, and the high viscosity of the flaxseed gum can form an elastic crosslinked network on the surface of the wall materials, so that the wall materials have larger mechanical strength and the release behavior of core materials is prevented; vegetable oil, animal oil or mineral oil is used as a core material, and the core material is gradually released under the coating of the wall material, so that the effects of long core material release time, good moisturizing effect and non-sticky skin feel are achieved; the lotus stalk extract and the sunflower root fermentation product are added into the wall material, so that the skin can be relieved, the aging can be delayed, the activity of SOD can be improved, and the ultraviolet protection effect can be improved; the rheology modifier is added while the moisturizing particles are added, so that the suspension capability of the skin care lotion can be improved, the dispersibility of the moisturizing particles in the skin care lotion can be improved, the aggregation of the moisturizing particles in the skin care lotion can be prevented, and the use effect of the skin care lotion can be influenced.
Optionally, the vegetable oil is selected from one or more of Mortierella dichotoma oil, avocado oil, oleum Cocois, grapeseed oil, jojoba oil, oleum Olivarum, oleum Armeniacae amarum, carrot seed oil, evening primrose oil, calendula oil, and Rosa canina oil, preferably Mortierella dichotoma oil;
the mineral oil is selected from one or more of vaseline and paraffin;
the animal oil is one or more selected from lanolin, beeswax, horse oil and squalene.
Through adopting above-mentioned technical scheme, vegetable oil, animal oil and mineral oil as the core, release gradually to the face, prevent skin moisture loss to reach the moisturizing effect, preferably use the argan nut oil, it can deep nourish, improve skin elasticity, make skin become clear smooth, anti-aging and prevent harmful bacterium, abundant vitamin E trades helps the whitening.
Optionally, the lotus stalk extracting solution is prepared by the following method: washing lotus stalk, cutting, heating to 80-100deg.C in distilled water, maintaining the temperature for 5-8 hr, ultrasonic treating under 2000-4000w for 20-30min, and filtering to obtain lotus stalk extractive solution.
By adopting the technical scheme, the fresh lotus stalk juice contains flavonoid compounds capable of removing most oxygen free radicals, particularly has the effects of relieving and reducing irritation to sensitive and tender skin, can endow skin with elasticity, strengthen skin softness, delay aging, regulate grease secretion, smooth and compact skin, make pores obviously fine and smooth, and can also improve the activity of superoxide dismutase, thereby enhancing the absorption effect of ultraviolet rays or the effect of inhibiting tyrosinase activity, removing free radicals generated by ultraviolet radiation and improving sun-screening effect.
Optionally, the sunflower root ferment is made by the following method: cleaning sunflower root, drying, pulverizing, adding water, dry yeast and Mel, mixing, sealing, fermenting for 15-25 days, sterilizing, centrifuging, and extracting with supercritical carbon dioxide fluid to obtain sunflower root fermented product with a mass ratio of 1:0.2-0.3:0.005-0.01.
By adopting the technical scheme, the sunflower roots have the effects of clearing heat, promoting diuresis, promoting qi circulation and relieving pain, the sunflower roots are used for extracting active substances by a fermentation process, the molecules of active ingredients are smaller and are easier to be absorbed by skin, the operation is simple, no foreign substances are added, the prepared sunflower root fermentation product is completely harmless to skin, contains natural ingredients such as amino acids, mineral substances and the like which are essential to healthy skin, is easy to absorb by skin, has strong oxidizing ability, can remove free radicals, promote cell metabolism, strengthen cell activity and delay aging.
Optionally, the wall material contains 0.5-1 part by weight of modified titanium dioxide particles, and the modified titanium dioxide particles are prepared by the following method: adding nano titanium dioxide particles into a mixed solution containing paraffin, petroleum ether and sophora flower extract, fully stirring, heating in a water bath to 65-70 ℃ to evaporate petroleum ether, and obtaining the modified titanium dioxide.
By adopting the technical scheme, the titanium dioxide is the most widely applied physical sun-screening agent, but the titanium dioxide belongs to the nanometer grade, has small particle size, is easy to agglomerate and poor in dispersibility, and the nanometer titanium dioxide can be absorbed by skin due to the size effect of the nanometer titanium dioxide to influence the health of a human body; therefore, the modified titanium dioxide is prepared by using the diethyl ether solution of the paraffin and the sophora flower extract, the paraffin can be coated on the modified titanium dioxide, the titanium dioxide can be prevented from being absorbed into a human body through skin, the sun-proof effect of the titanium dioxide is not affected, meanwhile, the sophora flower extract can convert ultraviolet rays absorbed by the skin into heat energy and harmless light to radiate out, the modified titanium dioxide is a natural sun-proof component, the sophora flower extract and the paraffin are jointly coated on the surface of the titanium dioxide to form a coating, the sun-proof effect of the titanium dioxide can be improved, and meanwhile, the titanium dioxide is prevented from being absorbed into the skin to affect the skin health.
Optionally mixing soybean protein and maltodextrin, adding oleum Lini, water, lotus stalk extractive solution, sunflower root fermented product and modified titanium dioxide granule, making into wall material, stirring wall material and core material, homogenizing, and spray drying to obtain moisture keeping granule
By adopting the technical scheme, soybean protein, maltodextrin and the like are used as wall materials, and the moisturizing particles are prepared after homogenization and spray drying, so that the preparation method is simple and easy to operate.
Optionally, the moisturizing particles are pretreated by: adding the moisturizing particles into PLGA diethyl ether solution with the mass concentration of 1-4%, uniformly mixing, adding sorbitan fatty acid ester diethyl ether solution with the mass concentration of 1-4%, stirring at 35-40 ℃ by ultrasonic wave, and spray drying.
By adopting the technical scheme, in order to improve the stability of the moisturizing particles in the skin care water and prevent aggregation, PLGA and sorbitan fatty acid ester are used for double emulsification of the moisturizing particles, so that the dispersion stability of the moisturizing particles is improved.
In a second aspect, the present application provides a preparation method of a skin care lotion for soothing and moisturizing, which adopts the following technical scheme: a preparation method of a soothing and moisturizing skin care lotion comprises the following steps:
uniformly mixing herba Portulacae extract, zinc gluconate, mel extract, humectant and copper gluconate, stirring, and heating to 70-80deg.C to obtain material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60-70deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, and making into skin care lotion.
By adopting the technical scheme, the prepared skin care lotion has good moisturizing effect, long-acting water locking effect, fresh skin feel, light weight and no greasiness.
Optionally, after adding the moisturizing particles and the rheology modifier, the pH value of the soothing and moisturizing lotion is adjusted to 5.5-6.
By adopting the technical scheme, the pH value of the skin care lotion is 6, under the condition, the release rate of the moisturizing particles is low, and the influence of the pH value on the stability of the wall material is prevented during the storage of the skin care lotion.
In summary, the present application has the following beneficial effects:
1. because the purslane extract, the honey extract, the hydrolyzed collagen, the humectant and other components are adopted, the humectant is composed of magnesium aspartate, hyaluronic acid and panthenol, the magnesium aspartate, the sodium hyaluronate and the panthenol have moisturizing and moisturizing effects, and in addition, the moisturizing and moisturizing effects are fresh and cool, and not greasy after the moisturizing and moisturizing components are mixed with the purslane extract, the honey extract and the like, the prepared skin care lotion has skin feel.
2. In the application, the moisturizing particles and the rheology modifier for improving the dispersibility of the moisturizing particles are preferably added into the skin care liquid, and the moisturizing particles are made into wall materials from soybean protein, lotus stalk extracting solution, sunflower root fermentation products and the like, and the wall materials are used as core materials from vegetable oil, animal oil or mineral oil, so that the moisturizing particles have fresh skin feel, the core materials are gradually released, a water locking barrier can be formed on the skin, and the long-acting moisturizing effect of the skin care liquid is improved.
3. In the application, modified titanium dioxide is preferably added into the wall material of the moisturizing particles, and the titanium dioxide is coated by a coating formed by paraffin and the pagodatree flower extract, so that the sun-proof effect of the skin care water can be improved, and meanwhile, the titanium dioxide is prevented from penetrating into the skin to influence the skin health.
4. In the present application, it is preferable to double-emulsify the moisturizing particles with PLGA and sorbitan fatty acid ester, so as to improve the dispersibility of the moisturizing particles and prolong the moisturizing time.
Detailed Description
Preparation example of moisturizing particles
The soybean protein in preparation examples 1-8 is selected from Jiangsu Heyuan biological engineering Co., ltd, and has a product number of 7528; maltodextrin is selected from Guangzhou Chuangxiao chemical Co, and has a product number of 002; the flaxseed gum is selected from Shandong long campsis bioengineering limited company, and has a product number of 101; the Morocco nut oil is selected from the group consisting of Guangzhou Kogyo Biotech Co., ltd, product number APO-004; the dry yeast is selected from the company Henan ocean Biotechnology Co., ltd, with the product number of 1122; the flos Sophorae Immaturus extract is selected from Siam excellent platinum sink biotechnology liability company, with product number 0140.
Preparation example 1: mixing 1kg of soybean protein and 1kg of maltodextrin, adding 0.1kg of flaxseed gum, 1kg of water, 0.5kg of lotus stalk extracting solution and 0.5kg of sunflower root fermented product, mixing as a wall material, uniformly stirring the wall material and a core material according to a mass ratio of 1:0.5, homogenizing, spray drying, and preparing moisturizing particles with a particle size of 80nm at a spray drying temperature of 175 ℃, wherein the core material is argan oil, and the lotus stalk extracting solution is prepared by the following method: washing lotus stems, cutting off, heating to 80 ℃ in distilled water, preserving heat for 8 hours, then carrying out ultrasonic treatment for 30 minutes under the condition of 2000w of power, filtering to obtain lotus stem extracting solution, and preparing sunflower root fermentation product by the following method: cleaning sunflower root, drying, pulverizing, adding water, dry yeast and Mel, mixing, sealing, fermenting for 25 days, sterilizing at 115deg.C for 20min, centrifuging at 4000r/min for 10min, and extracting with supercritical carbon dioxide fluid to obtain sunflower root fermented product with mass ratio of sunflower root, dry yeast and Mel of 1:0.3:0.01.
Preparation example 2: mixing 2kg of soybean protein with 2kg of maltodextrin, adding 0.15kg of flaxseed gum, 1.5kg of water, 1kg of lotus stalk extract and 1kg of sunflower root fermentation product, mixing, uniformly stirring the wall material and the core material according to the mass ratio of 1:0.7, homogenizing, spray drying, and preparing moisturizing particles with the particle size of 80nm at the spray drying temperature of 175 ℃, wherein the core material is argan oil, and the lotus stalk extract is prepared by the following steps: washing lotus stalks, cutting off, heating to 100 ℃ in distilled water, preserving heat for 5 hours, then carrying out ultrasonic treatment for 20 minutes under the condition of 4000w of power, filtering to obtain lotus stalk extracting solution, and preparing sunflower root fermentation product by the following method: cleaning sunflower root, drying, pulverizing, adding water, dry yeast and Mel, mixing, sealing, fermenting for 15 days, sterilizing at 115deg.C for 20min, centrifuging at 4000r/min for 10min, and extracting with supercritical carbon dioxide fluid to obtain sunflower root fermented product with mass ratio of sunflower root, dry yeast and Mel of 1:0.2:0.005.
Preparation example 3: the difference from preparation example 1 is that no lotus stalk extract was added.
Preparation example 4: the difference from preparation example 1 is that no sunflower root ferment was added.
Preparation example 5: the difference from preparation example 1 is that the wall material contains 0.5kg of modified titanium dioxide particles, the wall material is prepared by mixing 1kg of soybean protein and 1kg of maltodextrin, adding 0.1kg of linseed gum, 1kg of water, 0.5kg of lotus stalk extract, 0.5kg of sunflower root ferment and 0.5kg of modified titanium dioxide particles, and the wall material is prepared by the following method: adding 0.1kg of nano titanium dioxide particles into a mixed solution containing 0.01kg of paraffin, 1kg of petroleum ether and 0.05kg of sophora flower extract, fully stirring, heating to 65 ℃ in a water bath, and evaporating petroleum ether to obtain the modified titanium dioxide with the particle size of 30 nm.
Preparation example 6: the difference from preparation example 5 is that 1kg of modified titanium dioxide particles are contained in the wall material.
Preparation example 7: the difference from preparation example 5 is that no pagodatree flower extract was added to the modified titanium dioxide particles.
Preparation example 8: the difference from preparation example 5 is that the modified titanium dioxide particles were replaced with an equivalent amount of nano titanium dioxide particles having a particle diameter of 30 nm.
Examples
In the following examples and comparative examples, the source information of each raw material is as follows: the herba Portulacae (PORTULACA OLERACEA) extract is selected from ZX-POE, type number APE-011; the honey extract is selected from Shaanxi Siyang powder technology Co., ltd, and the product number is SY-SD033-1; the hydrolyzed collagen is selected from Acapris biological Co., ltd, model number is 4845, and the hyaluronic acid is selected from Shaanxi good fortune medicine science and technology Co., ltd, and the product number is H-YH01.
Example 1: the skin care lotion for relieving and moisturizing is prepared from the following raw materials in parts by weight: 1kg of purslane extract, 0.1kg of zinc gluconate, 0.08kg of preservative, 1kg of humectant, 0.25kg of hydrolyzed collagen, 1kg of honey extract, 0.1kg of copper gluconate, 0.5kg of ethylene glycol and 70kg of water, wherein the preservative is p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:0.8, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3:0.3.
The preparation method of the soothing and moisturizing lotion comprises the following steps of:
uniformly mixing purslane extract, zinc gluconate, honey extract, humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60deg.C to obtain material B, mixing material B and material A, homogenizing, and making into skin caring water.
Example 2: the difference between the soothing and moisturizing lotion and the lotion in example 1 is that the raw materials are as follows: 1.5kg of purslane extract, 0.3kg of zinc gluconate, 0.09kg of preservative, 1.5kg of humectant, 0.3kg of hydrolyzed collagen, 1.5kg of honey extract, 0.3kg of copper gluconate, 0.8kg of ethylene glycol and 75kg of water, wherein the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:0.5, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.5:0.1.
Example 3: the difference between the soothing and moisturizing lotion and the lotion in example 1 is that the raw materials are as follows: 2kg of purslane extract, 0.5kg of zinc gluconate, 0.1kg of preservative, 2kg of humectant, 0.5kg of hydrolyzed collagen, 2kg of honey extract, 0.5kg of copper gluconate, 1kg of glycol and 80kg of water, wherein the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:1, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3:0.1.
Example 4: the difference from example 1 is that the raw materials also comprise 0.5kg of moisturizing particles and 0.1kg of rheology modifier, wherein the moisturizing particles are prepared from preparation example 1, the rheology modifier is carbomer, and the preparation method of the moisturizing toner comprises the following steps: uniformly mixing purslane extract, zinc gluconate, honey extract, humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, and regulating pH to 5.5 to obtain skin care water.
Example 5: the moisturizing and skin-care lotion for relieving is different from the moisturizing and skin-care lotion in that the raw materials also comprise 1.5kg of moisturizing particles and 0.5kg of rheology modifier, wherein the moisturizing particles are prepared from preparation example 2, the rheology modifier is carbomer, and the moisturizing and skin-care lotion for relieving is prepared by the following steps: uniformly mixing purslane extract, zinc gluconate, honey extract, humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, and regulating pH to 6 to obtain skin care water with effects of relieving and moisturizing.
Example 6: a soothing and moisturizing lotion is different from example 5 in that moisturizing particles are prepared from preparation 3.
Example 7: a soothing and moisturizing lotion is different from example 5 in that moisturizing particles are prepared from preparation 4.
Example 8: a soothing and moisturizing lotion differs from example 5 in that moisturizing particles are prepared from preparation 5.
Example 9: a soothing and moisturizing lotion differs from example 5 in that moisturizing particles are made from preparation 6.
Example 10: a soothing and moisturizing lotion differs from example 5 in that moisturizing particles are made from preparation 7.
Example 11: a soothing and moisturizing lotion differs from example 5 in that moisturizing particles are made from preparation 8.
Example 12: a soothing and moisturizing lotion differs from example 5 in that no rheology modifier is added.
Example 13: a soothing and moisturizing lotion differs from example 5 in that after the addition of moisturizing particles and rheology modifiers, the pH is adjusted to 7.
Example 14: the difference between the soothing and moisturizing lotion and example 9 is that the moisturizing particles are pretreated as follows: adding the moisturizing particles into PLGA diethyl ether solution with the mass concentration of 1%, uniformly mixing, adding sorbitan fatty acid ester diethyl ether solution with the mass concentration of 1%, stirring at 35 ℃ in an ultrasonic manner, spray-drying at 170 ℃, and pretreating the moisturizing particles to obtain the moisturizing particles with the particle size of 120nm.
Example 15: the difference between the soothing and moisturizing lotion and example 9 is that the moisturizing particles are pretreated as follows: adding the moisturizing particles into PLGA diethyl ether solution with the mass concentration of 4%, uniformly mixing, adding sorbitan fatty acid ester diethyl ether solution with the mass concentration of 4%, stirring at 45 ℃ in an ultrasonic manner, spray drying at 170 ℃, and pretreating the moisturizing particles to obtain the moisturizing particles with the particle size of 120nm.
Example 16: the difference between the moisturizing lotion and the moisturizing lotion in example 15 is that moisturizing particles are added into an ether solution of sorbitan fatty acid ester with the mass concentration of 4%, and the mixture is subjected to ultrasonic stirring at 45 ℃, spray drying at 170 ℃ and the particle size of the moisturizing particles after pretreatment is 120nm.
Example 17: the difference between the moisturizing lotion and the moisturizing lotion in example 15 is that moisturizing particles are added into PLGA diethyl ether solution with the mass concentration of 4%, ultrasonic stirring is carried out at 45 ℃, spray drying is carried out, the spray drying temperature is 170 ℃, and the particle size of the moisturizing particles after pretreatment is 120nm.
Comparative example
Comparative example 1: the difference between the soothing and moisturizing lotion and example 1 is that hyaluronic acid is not added to the moisturizing agent.
Comparative example 2: a soothing and moisturizing lotion is different from example 1 in that magnesium aspartate is not added to the moisturizing agent.
Comparative example 3: a soothing and moisturizing lotion is different from example 1 in that panthenol is not added to the moisturizing agent.
Comparative example 4: a soothing and moisturizing lotion differs from example 1 in that no honey extract is added.
Comparative example 5: a toner containing purslane is prepared from the following raw materials in parts by weight: 40 parts of purslane extract, 3 parts of American ginseng essential oil, 3 parts of locust bean gum juice, 1 part of sorbitol, 2 parts of polyethylene glycol, 0.5 part of dendrobium candidum extract, 1 part of sodium hyaluronate, 0.3 part of lysine and 20 parts of deionized water;
the preparation method of the purslane toner comprises the following steps: adding herba Portulacae extractive solution, radix Panacis Quinquefolii essential oil, locust bean gum juice, sorbitol, polyethylene glycol, herba Dendrobii extractive solution, sodium hyaluronate and lysine into deionized water, and mixing to obtain herba Portulacae toner.
Performance test
Test one, patch test
1.1 test sample: the moisturizing lotion prepared in example 1, example 5 and example 15.
1.2 subject: 36 persons were selected (the same batch of subjects was used for each test sample).
1.3 test method: the test related information is taught to the subjects, and after the subjects sign the informed consent, the subjects are arranged with test numbers; allowing the subject to clean the inner sides of the forearms of the hands with tap water, and standing in a test environment for at least 35min after the tissues are wiped dry; taking a patch tester, breaking off small corners of the plastic protective cover with through holes, slightly pulling back the mating until all square cells are exposed, and taking care that the adhesive tape is not completely torn off from the protective cover; the test sample was taken 25ul at a time into a square-shaped chamber of the patch tester, the patch tester with the test object was applied to the inner side of the forearm of the subject, and the patch was applied to the skin uniformly by gentle finger pressure for 24 hours, and then removed.
1.4 observations: after 48 hours from the removal of the patch, the patch was interpreted according to the following criteria, and the test results were counted and shown in Table 1.
Interpretation criteria: negative reaction of (-); suspected reaction of (+ -): only mild erythema; (+) weak positive: erythema, infiltration, and possibly small papules; (++) strong positive: erythema, infiltration, papules, blisters; (+ ++ + electrode) strong positive: erythema, infiltration, papules, blisters and bullae.
TABLE 1 Patch test results
As can be seen from Table 1, the moisturizing and skin-care water patch prepared in example 1, example 5 and example 15 was safe and non-irritating.
Test two, long-lasting moisturizing and skin feel test
21. Test sample: skin lotions prepared in examples 1-17 and comparative examples 1-5.
2.2 subject: 200 healthy female volunteers are selected, the ages are 35-55 years, and the average of the healthy female volunteers is divided into 20 groups of 10 people at random;
2.3 test method: the subjects of each group were each applied to facial skin after seven facial cleansing points per day, with skin lotions prepared in examples 1-15 and comparative examples 1-5, 0.05g applied at a time, and the moisture content of the skin cuticle before and after application was measured by the skin moisture meter CM825 for 4h, 8h, and the feel at the time of application was recorded, and the different tests were scored according to the criteria in table 2, with higher scores indicating poorer skin feel and test results shown in table 3 (average score for 10 volunteers per group number in table 3).
Table 2 skin feel scoring criteria for skin lotions.
TABLE 3 Long-lasting moisturizing effect and skin feel test of skin lotions
As can be seen from the data in Table 3, in examples 1-3, the skin care lotion prepared by using hyaluronic acid, magnesium aspartate and panthenol as moisturizers and adding honey extract, purslane extract and the like has good moisturizing effect on skin, has strong long-acting moisturizing effect, and after being applied for 8 hours, the skin water content still reaches more than 43%, and the percutaneous moisture loss amount at 8 hours is-2.43, -2.26, -1.38%, so that the moisture loss amount is small, the moisturizing effect is good, and the lotion is dry, not greasy, light, thin and breathable after being applied, and is not tight after being applied.
Compared with example 1, example 4 and example 5 respectively add the moisturizing particles and the rheology modifier of preparation 1 and preparation 2 into the skin lotion, the skin lotions prepared in examples 4-5 have higher moisturizing effect on skin, the water content of the skin reaches more than 58% at 4 hours, and the water content of the skin continues to increase to more than 61% at 8 hours, so that the skin lotions have better long-acting moisturizing effect, and the skin feel is light, thin and non-sticky.
The moisturizing particles prepared in preparation examples 3 and 4 were added in examples 6 and 7, respectively, and the lotus stalk extract and sunflower root fermented product were not added in preparation examples 3 and 4, respectively, compared with preparation example 1, and the data in table 3 show that the moisturizing effect of the lotions of examples 6 and 7 on the skin was less than that of example 5.
In example 8 and example 9, compared with example 5, modified titanium dioxide is further added to the wall material when the moisturizing particles are prepared, the moisturizing particles prepared in example 8 and example 9 have an increased moisturizing effect on skin, the skin feel of the skin care lotion is not affected, and the skin care lotion still has a fresh, non-greasy, moisturizing and skin-friendly skin feel.
In example 10 and example 11, the moisturizing particles prepared in preparation example 7 and preparation example 8 were used, respectively, and no pagodatree flower extract was added in preparation example 7, and nano titanium dioxide was used instead of modified titanium dioxide in preparation example 8, and the moisturizing effect of the moisturizing liquid prepared in example 10 on the keratinous layer was inferior to that in example 9, and the moisturizing effect of the moisturizing liquid prepared in example 11 was not improved as compared with that in example 9.
In example 12, the pH of the skin lotion was adjusted to 7 as compared with example 9 without the addition of the rheology modifier, and in example 13, the skin lotion of example 12 was similar to example 9 in moisturizing effect and lighter and thinner in skin feel, and the skin lotion of example 13 had good instant moisturizing effect on the skin, but the skin moisture content was decreased and the long-acting moisturizing effect was decreased with the lapse of time.
In examples 14 to 17, the moisturizing particles were pretreated, and although the moisturizing effect was not significantly improved, the sticky feel of the lotion was reduced, and the lotion was lighter, thinner, breathable, and fresh and non-sticky.
In comparative example 1, hyaluronic acid was not added, and the instant moisturizing and long-acting water-locking effects of the skin care lotion prepared in comparative example 1 were reduced, and the skin feel was greasy and heavy, and the absorption effect was poor, as compared with example 1.
In comparative example 2, the long-acting moisturizing effect of the skin lotion is reduced, the skin feel score is increased, and the skin feel is poor, which shows that the addition of magnesium aspartate can make the skin lotion fresh, not sticky and smooth.
In comparative example 3, no panthenol was added, and the moisturizing effect of the skin lotion prepared in comparative example 3 was poor, the skin feel water wettability was poor, and the absorption was poor, as compared with example 1.
Comparative example 4 the moisturizing effect of the skin lotion prepared in comparative example 4 was reduced and the water wettability and absorption rate were deteriorated, compared with example 1, without adding the honey extract.
Comparative example 5 is a skin lotion containing purslane in the prior art, and comparison shows that the skin lotion in comparative example 5 has slow water supplementing speed, poor water locking effect, thick skin feel and no freshness.
Test three, stability test
3.1 test sample: skin care lotion prepared in examples 5, 8-17.
3.2 observer: 30.
The test method comprises the following steps: the skin care lotion was placed in a constant temperature airtight dryer under conditions of a relative humidity of 75%, an illumination intensity of 4500lx, and a temperature of 25 ℃, and after 1 month, 2 months, and 3 months, the state of the skin care lotion was observed by the observer, and the state of the skin care lotion was scored with reference to the scoring criteria in table 4, and the average value of scores of 30 observers was recorded in table 5.
Table 4 scoring results
| Scoring index | Scoring of |
| Uniform, fine, and free of delamination, aggregation, or precipitation | 30.5-40 min |
| The solution has a small amount of insoluble particles | 20.5-30 min |
| The solution is layered and insoluble particles are separated out | 10.5 to 20 minutes |
| The solution is obviously layered and has a large amount of insoluble particlesPrecipitation of | 0-10 min |
TABLE 5 stability test of skin lotions
As can be seen from the data in Table 5, the lotions prepared by adding the moisturizing particles and the rheology modifier in examples 5 and 8-10 have good stability without precipitation of insoluble particles after being left at room temperature.
The data in Table 5 shows that the skin lotion prepared in example 11 has a score of less than 30 minutes and a small amount of particles are precipitated after 3 months of placement.
In example 12, compared to example 9, no rheology modifier was added, and table 5 shows that the score was significantly reduced compared to example 9 when left for 1 month, and that the score was reduced by 25.2 minutes after 3 months of continuous placement, with poor stability.
In example 13, the pH was adjusted to 7, and the stability of the lotion was not much different from that of example 9, and insoluble particles were not precipitated.
Compared with example 9, example 14 and example 15 also have been pretreated with moisturizing particles, and after continuous standing, the skin care water prepared in example 14 and example 15 has no particle precipitation, no layering precipitation, higher evaluation score and better stability.
In examples 16 and 17, when the moisturizing particles were pretreated, PLGA and sorbitan fatty acid ester were not treated, respectively, and the evaluation score of the skin care lotion was reduced as compared with example 15.
Test IV, sun protection Effect test
4.1 test sample: the lotions prepared in examples 1 and 4-11.
4.2 subject: 80 volunteers were equally divided into 8 groups of 10 persons each.
4.3 test method: the method is tested by adopting an international human body efficacy test evaluation method and an in-vitro machine test method, and is referred to 2015 edition of cosmetic safety technical specification, and the instrument is an SPF-290AS sun protection factor measurement system of Solar Light company; the sunlight simulator xenon arc lamp is used as light source for testing, ultraviolet rays with wavelength of 290-400nm are continuously generated, the back is irradiated, the forward tilting position or the prone position can be adopted, the skin care water prepared by each embodiment is correspondingly coated on the back of each group of volunteers, and the area is not less than 30cm 2 At a rate of 2mg/cm 2 The method comprises the steps of (1) uniformly coating skin care water in a back test area by using a latex fingerstall, taking 5 points to irradiate with ultraviolet rays with different dosages, sequentially increasing irradiation dosages or time increment, observing a result after 24 hours, taking the lowest irradiation dosage or the shortest irradiation time of the skin with erythema as the minimum erythema MED of normal skin of a subject, obtaining unprotected skin MED and MPPD by adopting the same method, and obtaining a sun protection factor SPF and a protection factor PFA according to the following formula: sun Protection Factor (SPF) =skin MED with lotion/skin MED without lotion; PFA (protection factor) =skin MPDD with skin lotion/skin MPDD without skin lotion, and the test results are averaged for each group of test results and are recorded in table 6.
Surface 6 detection of Sun protection effect of skin care lotion
The data in Table 6 shows that the lotions prepared in example 1 have poor sunscreen performance and improved protection against UVA, whereas lotions prepared in examples 4 and 5 incorporating moisturizing particles have improved sunscreen performance, whereas lotions prepared in examples 6 and 7 have reduced sunscreen performance against UVA compared to example 5 without the addition of lotus leaf stalk extract and sunflower root ferment, respectively.
In examples 8 and 9, the addition of modified titanium dioxide to the wall material of the moisturizing particles increased the SPF value of the lotions prepared in examples 8-9 and enhanced the sunscreen effect as compared to example 5.
Example 10 compared with example 9, no pagodatree flower extract was added in the preparation of the modified titanium dioxide, the SPF value and PFA value of the skin care lotion were reduced, and the sun protection effect was reduced.
Example 11 compared to example 9, the use of nano titanium dioxide instead of modified nano titanium dioxide has significantly reduced sun protection and reduced protection against UVA.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (6)
1. The skin care lotion for relieving and moisturizing is characterized by comprising the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of ethylene glycol, 70-80 parts of water, 0.5-1.5 parts of moisturizing particles and 0.1-0.5 part of rheology modifier;
the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3-0.5:0.1-0.3;
the moisturizing particles comprise wall materials and core materials in a mass ratio of 1:0.5-0.7;
the wall material comprises the following components in parts by weight: 1-2 parts of soybean protein, 1-2 parts of maltodextrin, 0.5-1 part of lotus stalk extracting solution, 0.5-1 part of sunflower root fermentation product, 0.1-0.15 part of flaxseed gum, 1-1.5 parts of water and 0.5-1 part of modified titanium dioxide particles by weight;
the modified titanium dioxide particles are prepared by the following method: adding 0.1kg of nano titanium dioxide particles into a mixed solution containing 0.01kg of paraffin, 1kg of petroleum ether and 0.05kg of sophora flower extract, fully stirring, heating to 65 ℃ in a water bath, and evaporating petroleum ether to obtain modified titanium dioxide with the particle size of 30 nm;
the lotus stalk extracting solution is prepared by the following method: washing lotus stalks, cutting off, heating to 80-100deg.C in distilled water, maintaining the temperature for 5-8 hr, performing ultrasonic treatment under the power of 2000-4000W for 20-30min, and filtering to obtain lotus stalk extractive solution;
the sunflower root ferment is prepared by the following method: cleaning, drying and pulverizing sunflower roots, adding water, dry yeast and honey, uniformly mixing, sealing and fermenting for 15-25 days, sterilizing, centrifuging, and extracting with supercritical carbon dioxide fluid to obtain a sunflower root fermentation product, wherein the mass ratio of the sunflower roots to the dry yeast to the honey is 1:0.2-0.3:0.005-0.01;
the core material is one or more of vegetable oil, animal oil and mineral oil.
2. The soothing, moisturizing and skin-care lotion according to claim 1, wherein the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3:0.3.
3. The soothing and moisturizing lotion according to claim 1, wherein: the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:0.5-1.
4. The soothing, moisturizing and skin-care lotion according to claim 1, wherein the moisturizing particles are prepared by the following steps: mixing soybean protein and maltodextrin, adding flaxseed gum, water, extractive solution of lotus stalk, fermentation product of sunflower root and modified titanium dioxide granule, making into wall material, stirring wall material and core material uniformly, homogenizing, and spray drying to obtain the final product.
5. The soothing, moisturizing and skin-care lotion according to claim 4, wherein the moisturizing particles are pretreated by: adding the moisturizing particles into PLGA diethyl ether solution with the mass concentration of 1-4%, uniformly mixing, adding sorbitan fatty acid ester diethyl ether solution with the mass concentration of 1-4%, stirring at 35-40 ℃ by ultrasonic wave, and spray drying.
6. The method for preparing the soothing and moisturizing lotion according to any one of claims 1 to 5, comprising the following steps:
uniformly mixing herba Portulacae extract, zinc gluconate, mel extract, humectant and copper gluconate, stirring, and heating to 70-80deg.C to obtain material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60-70deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, and making into skin care lotion.
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