CN114748406A - Soothing and moisturizing skin moisturizer and preparation method thereof - Google Patents
Soothing and moisturizing skin moisturizer and preparation method thereof Download PDFInfo
- Publication number
- CN114748406A CN114748406A CN202210514552.9A CN202210514552A CN114748406A CN 114748406 A CN114748406 A CN 114748406A CN 202210514552 A CN202210514552 A CN 202210514552A CN 114748406 A CN114748406 A CN 114748406A
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- Prior art keywords
- moisturizing
- skin
- soothing
- lotion
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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Abstract
The application relates to the field of cosmetics, and particularly discloses a soothing and moisturizing lotion and a preparation method thereof. The soothing moisturizing skin care lotion comprises the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of glycol and 70-80 parts of water; the humectant comprises hyaluronic acid, magnesium aspartate and panthenol which are mixed according to the mass ratio of 1 (0.3-0.5) to 0.1-0.3. The soothing moisturizing lotion has the advantages of being good in moisturizing effect, capable of locking water for a long time, lasting in moisturizing effect and having a sun-screening effect.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to soothing and moisturizing skin lotion and a preparation method thereof.
Background
The skin lotion can also be firming lotion, smoothing lotion, toner and the like, has the main functions of helping the skin to moisturize, astringe pores and improve the skin firmness after cleaning the face, contains a large amount of nutrient substances, can provide rich nutrition for the skin, regulates the moisture and the wind of the skin, and moistens the skin to make the skin softer and more glossy. Whether the skin is full of moisture directly influences the external complexion of a person, a series of skin problems such as skin dryness, wrinkling, molting, allergy and the like can be caused, and the makeup effect can be influenced, so that the skin care lotion meets the psychological needs of high-end consumption to a great extent, and is an effective way for consumers to moisturize and supplement skin nutrition.
The existing moisturizing components mainly comprise water-soluble, oil-soluble and high-molecular components, but the oil-soluble moisturizing components are difficult to dissolve in water, the skin feel is sticky, the water-soluble moisturizing components are easy to absorb by the skin due to small molecular weight, but the long-acting moisturizing performance is poor, the high-molecular components such as sodium hyaluronate and the high-molecular sodium hyaluronate mainly play a moisturizing effect, the low-molecular sodium hyaluronate mainly plays a moisturizing effect, but the skin feel of the sodium hyaluronate with higher molecular weight is sticky, if the skin feel is improved, the quantity of the medium-molecular weight and the quantity of the oligomeric sodium hyaluronate are required to be increased to achieve a refreshing and natural effect, and the production cost is inevitably increased.
In view of the above-mentioned related technologies, the inventors found that there is a need to develop a skin lotion which has a long moisturizing effect and is refreshing and non-sticky.
Disclosure of Invention
In order to improve the long-acting moisture retention property of the skin moisturizer and reduce the sticky feeling of the skin moisturizer, the application provides the soothing moisture retention skin moisturizer and the preparation method thereof.
In a first aspect, the application provides a soothing and moisturizing lotion, which adopts the following technical scheme:
the soothing moisturizing skin care lotion comprises the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of glycol and 70-80 parts of water;
the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1 (0.3-0.5) to 0.1-0.3.
By adopting the technical scheme, the purslane extract, the honey extract, the copper gluconate, the zinc gluconate and the like are used for preparing the skin care lotion, the purslane extract is mild and mild, moisturized and antioxidant, has fresh texture and good fluidity, amino acids in the purslane extract can shrink blood vessels, smooth skin, sooth skin and inhibit skin itch caused by dryness, the honey extract has the effects of moisturizing and long-acting nourishing, the moisturizing agent consists of hyaluronic acid, magnesium aspartate and panthenol, the hyaluronic acid is favorable for moisturizing and maintaining elasticity of the skin, moisturizing and locking water, the barrier function is maintained, the anti-aging effect, the free radical damage prevention and the anti-saccharification effect are also achieved, the magnesium aspartate has the antioxidant effect and the anti-aging effect, the skin feel of the panthenol is relatively fresh and cool and not sticky, the molecules are small, the permeability is good, the moisturizing effect is strong, and the zinc gluconate can inhibit the synthesis of free fatty acid, the skin care lotion prepared by the method has good repairing and relieving effects, can effectively relieve the skin, calms the skin state, is very mild, has no irritation and can be used for sensitive muscles.
Optionally, the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3: 0.3.
By adopting the technical scheme, the dosage of each component in the humectant is further accurately controlled, so that the moisturizing and water locking effects of the skin moisturizer are better and more remarkable.
Optionally, the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1 (0.5-1).
By adopting the technical scheme, the storage life of the skin care lotion can be prolonged by adding the p-hydroxyacetophenone and the 1, 2-hexanediol, and the skin care lotion is prevented from being polluted in the using process.
Optionally, the soothing and moisturizing lotion further comprises 0.5-1.5 parts by weight of moisturizing particles and 0.1-0.5 part by weight of rheology modifier, wherein the moisturizing particles comprise wall materials and core materials in a mass ratio of 1: 0.5-0.7;
the wall material comprises the following components in parts by weight: 1-2 parts of soybean protein, 1-2 parts of maltodextrin, 0.5-1 part of lotus petiole extracting solution, 0.5-1 part of sunflower root fermented product, 0.1-0.15 part of flaxseed gum and 1-1.5 parts of water;
the core material is one or more of vegetable oil, animal oil and mineral oil.
In order to further improve the deep water locking effect of the skin care water, the effect is generally achieved by improving the oil content in a skin care water system, but the viscosity of the skin care water is inevitably improved by increasing the oil content, so that the skin care water is sticky and heavy, and the skin feel is reduced; vegetable oil, animal oil or mineral oil is used as a core material, and the core material is gradually released under the coating of the wall material, so that the effects of long release time of the core material, good moisturizing effect and non-sticky skin feel are achieved; the lotus petiole extracting solution and the sunflower root leavening are added into the wall material, so that the skin can be relieved, the aging can be delayed, the SOD activity can be improved, and the ultraviolet protection effect can be improved; the rheological modifier is added while the moisturizing particles are added, so that the suspension capacity of the skin care lotion can be improved, the dispersibility of the moisturizing particles in the skin care lotion can be improved, and the moisturizing particles are prevented from being aggregated in the skin care lotion to influence the using effect of the skin care lotion.
Optionally, the vegetable oil is selected from one or more of argan oil, avocado oil, coconut oil, grape seed oil, jojoba oil, olive oil, almond oil, carrot seed oil, evening primrose oil, calendula oil, and rose hip oil, preferably argan oil;
the mineral oil is selected from one or more of vaseline and paraffin;
the animal oil is selected from one or more of lanolin, beeswax, horse oil and squalene.
By adopting the technical scheme, the vegetable oil, the animal oil and the mineral oil are taken as core materials and are gradually released to the face to prevent the moisture of the skin from losing so as to achieve the moisturizing effect, and the argan oil is preferably used, so that the argan oil can be deeply nourished, the elasticity of the skin is improved, the skin becomes clear and smooth, the anti-aging effect is realized, the harmful bacteria are prevented, and the abundant vitamin E is changed to help whitening.
Optionally, the petiolus nelumbinis extract is prepared by the following method: cleaning lotus petiole, cutting, heating in distilled water to 80-100 deg.C, maintaining the temperature for 5-8h, performing ultrasonic treatment at power of 2000-.
By adopting the technical scheme, the fresh lotus petiole juice contains flavonoid compounds capable of removing most of oxygen free radicals, particularly sensitive and delicate skin, has the effects of relieving and reducing stimulation, endows the skin with elasticity, strengthens the softness of the skin, delays aging, regulates grease secretion, smoothes and compacts the skin, enables pores to become fine and smooth obviously, and can improve the activity of superoxide dismutase, so that the absorption effect on ultraviolet rays or the effect of inhibiting the activity of tyrosinase is enhanced, the effect of removing the free radicals generated by ultraviolet radiation is realized, and the sun-screening effect is improved.
Optionally, the sunflower root ferment is prepared by the following method: cleaning sunflower roots, drying, crushing, adding water, dry yeast and honey, uniformly mixing, sealing, fermenting for 15-25 days, sterilizing, centrifuging, and extracting by supercritical carbon dioxide fluid to obtain a sunflower root fermented product, wherein the mass ratio of the sunflower roots to the dry yeast to the honey is 1:0.2-0.3: 0.005-0.01.
By adopting the technical scheme, the sunflower roots have the effects of clearing heat, promoting diuresis, promoting qi circulation and relieving pain, active substances are extracted from the sunflower roots by using a fermentation process, the molecules of the active ingredients are smaller, the active ingredients are easier to absorb by the skin, the operation is simple, no foreign substance is added, the prepared sunflower root fermentation product is completely harmless to the skin, contains natural ingredients such as amino acid and mineral substances which are indispensable to healthy skin, is easy to absorb by the skin, has strong oxidizing capability, can clear free radicals, promotes cell metabolism, enhances cell activity and delays aging.
Optionally, the wall material contains 0.5-1 part by weight of modified titanium dioxide particles, and the modified titanium dioxide particles are prepared by the following method: adding nanometer titanium dioxide particles into the mixed solution containing paraffin, petroleum ether and flos Sophorae Immaturus extract, stirring, heating in water bath to 65-70 deg.C, and evaporating petroleum ether to obtain modified titanium dioxide.
By adopting the technical scheme, titanium dioxide is the most widely applied physical sun-screening agent, but the titanium dioxide belongs to the nanometer grade, has small particle size, is easy to agglomerate and has poor dispersibility, and the nanometer titanium dioxide can be absorbed by skin due to the size effect of the nanometer titanium dioxide, so that the health of a human body is influenced; therefore, the modified titanium dioxide is prepared by using the ether solution of the paraffin and the sophora flower extract, the paraffin can be coated on the modified titanium dioxide, the titanium dioxide can be prevented from being absorbed into a human body through skin, the sun-proof effect of the titanium dioxide is not influenced, meanwhile, ultraviolet rays absorbed by the skin can be converted into heat energy and harmless light to be radiated out by the sophora flower extract, the modified titanium dioxide is a natural sun-proof component, the sophora flower extract and the paraffin are coated on the surface of the titanium dioxide together to form a coating, the sun-proof effect of the titanium dioxide can be improved, and the phenomenon that the ultraviolet rays are absorbed into the skin to influence the health of the skin is prevented.
Optionally, mixing soybean protein and maltodextrin, adding flaxseed gum, water, extractive solution of petiolus Nelumbinis, fermented product of radix Helianthi and modified titanium dioxide particles, making into wall material, stirring wall material and core material uniformly, homogenizing, spray drying, and making into moisture-keeping granule
By adopting the technical scheme, the moisturizing particles are prepared by taking the soybean protein, the maltodextrin and the like as wall materials and carrying out homogenization and spray drying, and the preparation method is simple and easy to operate.
Optionally, the moisture-retaining particles are pretreated by: adding the moisture-keeping particles into a PLGA ether solution with the mass concentration of 1-4%, uniformly mixing, adding a sorbitan fatty acid ester ether solution with the mass concentration of 1-4%, ultrasonically stirring at 35-40 ℃, and spray-drying.
By adopting the technical scheme, in order to improve the stability of the moisturizing particles in the skin care water and prevent the moisturizing particles from aggregating, PLGA and sorbitan fatty acid ester are used for double emulsification of the moisturizing particles, so that the dispersion stability of the moisturizing particles is improved.
In a second aspect, the application provides a preparation method of soothing and moisturizing skin care lotion, which adopts the following technical scheme: a preparation method of soothing and moisturizing skin care lotion comprises the following steps:
uniformly mixing the purslane extract, zinc gluconate, the honey extract, the humectant and copper gluconate, stirring and heating to 70-80 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60-70 deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, and homogenizing to obtain soothing moisturizing skin care lotion.
By adopting the technical scheme, the prepared skin moisturizer is good in moisturizing effect, has a long-acting moisturizing effect, is fresh and cool in skin feeling, and is light, thin and non-greasy.
Optionally, after the moisturizing particles and the rheology modifier are added, the pH value of the soothing moisturizing lotion is adjusted to 5.5-6.
By adopting the technical scheme, the pH value of the skin care water is 6, under the condition, the release rate of the moisturizing particles is low, and the pH value is prevented from influencing the stability of the wall material during the storage period of the skin care water.
In summary, the present application has the following beneficial effects:
1. because the purslane extract, the honey extract, the hydrolyzed collagen, the humectant and other components are adopted, and the humectant is composed of magnesium aspartate, hyaluronic acid and panthenol, the magnesium aspartate, sodium hyaluronate and panthenol have the effects of moisturizing and moisturizing, and in addition, after the purslane extract, the honey extract and the like are mixed, the prepared skin-care lotion has fresh and non-greasy skin feeling.
2. In the application, the moisturizing particles and the rheology modifier for improving the dispersibility of the moisturizing particles are preferably added into the skin care water, the moisturizing particles are made into wall materials by soybean protein, lotus petiole extracting solution, sunflower root leavening and the like, the vegetable oil, the animal oil or the mineral oil is used as a core material, the wall materials can enable the moisturizing particles to have fresh skin feel, and the core material is gradually released, so that a water-locking barrier can be formed on the skin, and the long-acting moisturizing effect of the skin care water is improved.
3. In the application, modified titanium dioxide is preferably added into the wall material of the moisturizing particles, and the titanium dioxide is coated by a coating formed by paraffin and a sophora flower extract, so that the sunscreen effect of the skin moisturizer can be improved, and the titanium dioxide is prevented from permeating into the skin to influence the health of the skin.
4. In the application, PLGA and sorbitan fatty acid ester are preferably used for double emulsification of the moisturizing particles, so that the dispersibility of the moisturizing particles is improved, and the moisturizing time of the moisturizing particles is prolonged.
Detailed Description
Preparation example of moisturizing particles
The soybean protein of preparation examples 1-8 was selected from Jiangsu Jinhe biological engineering Co., Ltd, cat # 7528; the maltodextrin is selected from Guangzhou Chuangyou chemical Limited company with the product number of 002; the flaxseed gum is selected from Shandong Changxiao bioengineering Co., Ltd, with a product number of 101; the Argan oil is selected from Asahi Hill bioscience, Guangzhou, with a product number of APO-004; the dry yeast is selected from Henan Zhou ocean Biotechnology Co., Ltd, product number 1122; the flos Sophorae Immaturus extract is selected from Siemens Pou Biotech, Inc. of 0140.
Preparation example 1: mixing 1kg of soybean protein and 1kg of maltodextrin, adding 0.1kg of flaxseed gum, 1kg of water, 0.5kg of lotus petiole extracting solution and 0.5kg of sunflower root leavening, mixing to serve as a wall material, uniformly stirring the wall material and a core material according to a mass ratio of 1:0.5, homogenizing, spray-drying, wherein the spray-drying temperature is 175 ℃, and preparing moisturizing particles with the particle size of 80nm, the core material is argan oil, and the lotus petiole extracting solution is prepared by the following method: cleaning lotus petiole, cutting, heating in distilled water to 80 deg.C, keeping the temperature for 8h, performing ultrasonic treatment at power of 2000w for 30min, and filtering to obtain lotus petiole extractive solution, wherein the sunflower root fermented product is prepared by the following method: cleaning sunflower roots, drying, pulverizing, adding water, dry yeast and honey, mixing uniformly, sealing, fermenting for 25 days, sterilizing at 115 ℃ for 20min, centrifuging at the rotating speed of 4000r/min for 10min, and extracting with supercritical carbon dioxide fluid to obtain a sunflower root fermented product, wherein the mass ratio of the sunflower roots to the dry yeast to the honey is 1:0.3: 0.01.
Preparation example 2: mixing 2kg of soybean protein and 2kg of maltodextrin, adding 0.15kg of flaxseed gum, 1.5kg of water, 1kg of lotus petiole extracting solution and 1kg of sunflower root leavening, mixing to serve as a wall material, uniformly stirring the wall material and a core material according to the mass ratio of 1:0.7, homogenizing, and performing spray drying at the temperature of 175 ℃ to prepare moisture-preserving particles with the particle size of 80nm, wherein the core material is argan oil, and the lotus petiole extracting solution is prepared by the following method: cleaning lotus petiole, cutting, placing in distilled water, heating to 100 ℃, preserving heat for 5h, then carrying out ultrasonic treatment for 20min under the condition that the power is 4000w, and filtering to obtain a lotus petiole extracting solution, wherein the sunflower root fermentation product is prepared by the following method: cleaning sunflower roots, drying, pulverizing, adding water, dry yeast and honey, mixing uniformly, sealing, fermenting for 15 days, sterilizing at 115 ℃ for 20min, centrifuging at the rotating speed of 4000r/min for 10min, and extracting with supercritical carbon dioxide fluid to obtain a sunflower root fermented product, wherein the mass ratio of the sunflower roots to the dry yeast to the honey is 1:0.2: 0.005.
Preparation example 3: the difference from preparation example 1 is that no petiole extract was added.
Preparation example 4: the difference from preparation example 1 is that the sunflower root fermented product was not added.
Preparation example 5: the difference from preparation example 1 is that the wall material contains 0.5kg of modified titanium dioxide particles, the wall material is prepared by mixing 1kg of soy protein and 1kg of maltodextrin, and adding 0.1kg of flaxseed gum, 1kg of water, 0.5kg of lotus petiole extract, 0.5kg of sunflower root ferment and 0.5kg of modified titanium dioxide particles to mix and prepare the wall material, and the modified titanium dioxide particles are prepared by the following method: adding 0.1kg of nanometer titanium dioxide particles into a mixture containing 0.01kg of paraffin, 1kg of petroleum ether and 0.05kg of flos Sophorae Immaturus extract, stirring, heating in water bath to 65 deg.C, and evaporating petroleum ether to obtain modified titanium dioxide with particle diameter of 30 nm.
Preparation example 6: the difference from preparation example 5 is that 1kg of modified titanium dioxide particles was contained in the wall material.
Preparation example 7: the difference from preparation example 5 is that the modified titanium dioxide particles were not added with the sophora flower extract.
Preparation example 8: the difference from preparation example 5 was that nano-sized titanium dioxide particles having an equivalent particle diameter of 30nm were used instead of the modified titanium dioxide particles.
Examples
In the following examples and comparative examples, the source information of each raw material is as follows: the herba Portulacae (Portulaca Oleracea) extract is selected from ZX-POE, product number APE-011, Guangzhou Korea Biotech Co., Ltd; the honey extract is selected from Shanxi Saiyang powder technology GmbH, with a product number of SY-SD 033-1; the hydrolyzed collagen is selected from Acylpruis biology, Inc., model No. 4845, and the hyaluronic acid is selected from Shaanxi Haoyun medicine science and technology, Inc., and its product number is H-YH 01.
Example 1: the soothing and moisturizing skin care lotion comprises the following raw materials in parts by weight: 1kg of purslane extract, 0.1kg of zinc gluconate, 0.08kg of preservative, 1kg of humectant, 0.25kg of hydrolyzed collagen, 1kg of honey extract, 0.1kg of copper gluconate, 0.5kg of glycol and 70kg of water, wherein the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:0.8, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3: 0.3.
The preparation method of the soothing moisturizing skin care lotion comprises the following steps:
uniformly mixing the purslane extract, zinc gluconate, the honey extract, the humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60 deg.C to obtain material B, mixing material B and material A, and homogenizing to obtain soothing and moisturizing skin care lotion.
Example 2: a soothing and moisturizing skin care lotion is different from the lotion in example 1 in that the lotion comprises the following raw materials: 1.5kg of purslane extract, 0.3kg of zinc gluconate, 0.09kg of preservative, 1.5kg of humectant, 0.3kg of hydrolyzed collagen, 1.5kg of honey extract, 0.3kg of copper gluconate, 0.8kg of glycol and 75kg of water, wherein the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:0.5, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.5: 0.1.
Example 3: a soothing and moisturizing skin lotion is different from the lotion in example 1 in that the raw materials are used in the following amounts: 2kg of purslane extract, 0.5kg of zinc gluconate, 0.1kg of preservative, 2kg of humectant, 0.5kg of hydrolyzed collagen, 2kg of honey extract, 0.5kg of copper gluconate, 1kg of glycol and 80kg of water, wherein the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol in a mass ratio of 1:1, and the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1:0.3: 0.1.
Example 4: the difference of the soothing and moisturizing skin lotion from example 1 is that the raw materials also comprise 0.5kg of moisturizing particles and 0.1kg of rheological modifier, the moisturizing particles are prepared from preparation example 1, the rheological modifier is carbomer, and the soothing and moisturizing skin lotion is prepared by the following method: uniformly mixing the purslane extract, zinc gluconate, the honey extract, the humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60 deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, adjusting pH to 5.5, and making into soothing moisturizing lotion.
Example 5: a soothing and moisturizing lotion is different from example 1 in that raw materials further comprise 1.5kg of moisturizing particles and 0.5kg of rheological modifier, the moisturizing particles are prepared from preparation example 2, the rheological modifier is carbomer, and the soothing and moisturizing lotion is prepared by the following method: uniformly mixing the purslane extract, zinc gluconate, the honey extract, the humectant and copper gluconate, stirring and heating to 70 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60 deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, homogenizing, adjusting pH to 6, and making into soothing and moisturizing lotion.
Example 6: a soothing moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 3.
Example 7: a soothing moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 4.
Example 8: a soothing moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 5.
Example 9: a soothing moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 6.
Example 10: a soothing and moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 7.
Example 11: a soothing moisturizing lotion is different from example 5 in that moisturizing particles are prepared according to preparation example 8.
Example 12: a soothing moisturizing lotion, differing from example 5 in that no rheology modifier was added.
Example 13: a soothing moisturizing lotion, differing from example 5 in that after the moisturizing particles and rheology modifier are added, the pH is adjusted to 7.
Example 14: a soothing moisturizing lotion, which is different from example 9 in that moisturizing particles are pretreated by: adding the moisture-retaining particles into a PLGA ether solution with the mass concentration of 1%, uniformly mixing, adding a sorbitan fatty acid ester ether solution with the mass concentration of 1%, ultrasonically stirring at 35 ℃, and carrying out spray drying at the temperature of 170 ℃, wherein the particle size of the moisture-retaining particles is 120nm after pretreatment.
Example 15: a soothing moisturizing lotion, which is different from example 9 in that moisturizing particles are pretreated by: adding the moisture-retaining particles into a PLGA ether solution with the mass concentration of 4%, uniformly mixing, adding a sorbitan fatty acid ester ether solution with the mass concentration of 4%, ultrasonically stirring at 45 ℃, and carrying out spray drying at the temperature of 170 ℃, wherein the particle size of the moisture-retaining particles is 120nm after pretreatment.
Example 16: a soothing and moisturizing lotion is different from that in example 15 in that moisturizing particles are added into a 4% by mass sorbitan fatty acid ester ether solution, ultrasonically stirred at 45 ℃, and spray-dried, wherein the spray-drying temperature is 170 ℃, and the particle size of the moisturizing particles is 120nm after pretreatment.
Example 17: a soothing and moisturizing lotion, which is different from the lotion prepared in example 15 in that moisturizing particles are added into a 4% PLGA ether solution by mass concentration, ultrasonically stirred at 45 ℃, and spray-dried, wherein the spray-drying temperature is 170 ℃, and the particle size of the moisturizing particles is 120nm after pretreatment.
Comparative example
Comparative example 1: a soothing and moisturizing skin lotion is different from that in example 1 in that hyaluronic acid is not added to a moisturizing agent.
Comparative example 2: a soothing and moisturizing skin lotion is different from that in example 1 in that magnesium aspartate is not added in a moisturizing agent.
Comparative example 3: a soothing and moisturizing skin lotion is different from that in example 1 in that panthenol is not added to a moisturizer.
Comparative example 4: a soothing and moisturizing skin lotion is different from that of example 1 in that honey extract is not added.
Comparative example 5: a purslane-containing toner is prepared from the following raw materials in parts by weight: 40 parts of purslane extract, 3 parts of American ginseng essential oil, 3 parts of locust bean gum juice, 1 part of sorbitol, 2 parts of polyethylene glycol, 0.5 part of dendrobium officinale extract, 1 part of sodium hyaluronate, 0.3 part of lysine and 20 parts of deionized water;
the preparation method of the purslane toner comprises the following steps: adding the purslane extract, American ginseng essential oil, locust bean gum, sorbitol, polyethylene glycol, dendrobium officinale extract, sodium hyaluronate and lysine into deionized water, and uniformly mixing to obtain the purslane toner.
Performance test
Test one, patch test
1.1 test sample: the soothing and moisturizing skin lotion prepared in the examples 1, 5 and 15.
1.2 subjects: 36 persons were selected (same batch of subjects was used for each test sample).
1.3 test methods: explaining test related information to the subject, and arranging a test number for the subject after the subject signs an informed consent form; cleaning the inner sides of the forearms of the hands of the testee by using tap water, and standing for at least 35min in a test environment after wiping the forearms with a paper towel; taking a spot tester, breaking off the small corner of the hole punched by the plastic protective cover, slightly pulling the intersection backwards until all the square small chambers are exposed, and paying attention to prevent the adhesive tape from being completely torn off from the protective cover; taking 25ul of test sample into a square chamber of a spot tester at a time, applying the spot tester with the test object on the inner side of the forearm of the subject, lightly pressing with fingers to uniformly apply the spot tester on the skin, and removing the spot tester after 24 h.
1.4 observations: and judging and reading 48 hours after the patch applicator is removed according to the following judgment standard, and counting the test results, wherein the test results are shown in the table 1.
Interpretation criteria: a (-) negative reaction; (+ -) suspicious reaction: only mild erythema; (+) weak positive: erythema, infiltrates, and possibly small amounts of papules; strong positive (++): erythema, infiltrates, papules, blisters; (+++) very strong positive: erythema, infiltrates, papules, blisters, bulla.
TABLE 1 Patch test results
As can be seen from Table 1, the soothing moisturizing skin care patches prepared in examples 1, 5 and 15 were safe and non-irritating in the patch test.
Test two, Long-term moisturizing and skin feel test
21. Test samples: skin lotions prepared in examples 1-17 and comparative examples 1-5.
2.2 subjects: selecting 200 healthy female volunteers, wherein the age is 35-55 years, and the healthy female volunteers are randomly and averagely divided into 20 groups of 10 persons in each group;
2.3 test methods: each group of subjects cleaned their face seven times a day before applying 0.05g of the skin lotion prepared in examples 1-15 and comparative examples 1-5 to the facial skin, measured the moisture content of the stratum corneum before and after application for 4h and 8h using a skin moisture meter CM825, and recorded the sensation immediately after application, and the different tests were scored according to the standards in table 2, with higher scores indicating poorer skin feel, and the results are shown in table 3 (the values for each group in table 3 are the average scores of 10 volunteers).
Table 2 skin feel scoring criteria for skin lotions.
Table 3 long-lasting moisturizing effect and skin feel test of skin lotions
As can be seen from the data in table 3, the skin lotion prepared by using hyaluronic acid, magnesium aspartate and panthenol as moisturizers and adding honey extract, purslane extract and the like in examples 1-3 has good moisturizing effect on skin and strong long-acting moisturizing effect, the water content of the skin still reaches more than 43% after being smeared for 8 hours, the transdermal water loss at 8 hours is-2.43, -2.26, -1.38%, the water loss is small, the water-locking moisturizing effect is good, and the skin lotion is dry, non-greasy, light, breathable and not tight on the face after being smeared.
Compared with the example 1, the moisturizing particles and the rheology modifier in the preparation examples 1 and 2 are respectively added into the skin moisturizer in the examples 4 and 5, the skin moisturizer prepared in the examples 4 to 5 has a higher moisturizing effect on the skin, the water content of the skin reaches over 58% in 4 hours, and the water content of the skin continuously increases to over 61% in 8 hours, so that the skin moisturizer has a better long-term moisturizing effect, and is light, thin and non-sticky in skin feel.
In example 6 and example 7, the moisturizing granules prepared in preparation example 3 and preparation example 4 were added, respectively, and in preparation example 3 and preparation example 4, the lotus petiole extract and the sunflower root fermented product were not added, respectively, as compared with preparation example 1, and the data in table 3 shows that the skin moisturizers of example 6 and example 7 have less moisturizing effect on the skin than that of example 5.
Compared with example 5, in examples 8 and 9, modified titanium dioxide is further added into the wall material when the moisturizing particles are prepared, so that the moisturizing effect of the moisturizing particles prepared in examples 8 and 9 on the skin is increased, the skin feel of the skin lotion is not affected, and the skin lotion still has fresh, non-greasy, water-moistening and skin-friendly skin feel.
Examples 10 and 11 compared to example 5, the moisturizing particles prepared in preparation examples 7 and 8 were used, respectively, the sophora flower extract was not added in preparation example 7, the nano titanium dioxide was used instead of the modified titanium dioxide in preparation example 8, the moisturizing effect of the skin moisturizer prepared in example 10 on the stratum corneum was inferior to that of example 9, and the moisturizing effect of the skin moisturizer prepared in example 11 compared to example 9 was not improved.
Compared with the example 9, the pH value of the skin moisturizer is adjusted to 7 in the example 12 without adding the rheology modifier, compared with the example 9, the moisturizing effect of the skin moisturizer in the example 12 is similar to that in the example 9, the skin feel is lighter and thinner, and the skin moisturizer prepared in the example 13 has a good instant moisturizing effect on the skin, but the moisture content of the skin is reduced and the long-term moisturizing effect is reduced along with the prolonging of the time.
In examples 14 to 17, the moisturizing particles were pretreated, and although the moisturizing effect was not significantly improved, the skin lotion was less sticky, lighter, more breathable, refreshing, and less sticky.
Compared with the skin care lotion prepared in example 1, the skin care lotion prepared in comparative example 1 has reduced instant water replenishing and long-acting water locking effects, oily and heavy skin feel and poor absorption effect because hyaluronic acid is not added in comparative example 1.
In comparative example 2, magnesium aspartate is not added, the long-acting moisturizing effect of the skin lotion is reduced, the skin feel score is increased, and the skin feel is poor, which shows that the skin lotion is fresh and cool in water, not sticky, and smooth in skin feel by adding the magnesium aspartate.
Compared with example 1, the skin lotion prepared in comparative example 3 has poor moisturizing effect, poor skin feeling and moisture and poor absorption condition because panthenol is not added in comparative example 3.
Comparative example 4 compared to example 1, the moisturizing effect of the skin lotion prepared in comparative example 4 was decreased without adding the honey extract, and the degree of moisturization and absorption rate were deteriorated.
The comparative example 5 is the skincare lotion containing purslane in the prior art, and the comparison shows that the skincare lotion in the comparative example 5 is slow in moisturizing speed, poor in moisturizing effect, thick in skin feel and not greasy and refreshing.
Test III, stability test
3.1 test samples: skin lotions made according to examples 5, 8-17.
3.2 observer: 30 names.
The test method comprises the following steps: the skin lotion was placed in a constant temperature closed desiccator at a relative humidity of 75%, a light intensity of 4500lx and a temperature of 25 ℃, and after 1 month, 2 months and 3 months, the state of the skin lotion was observed by the observer, and the state of the skin lotion was scored with reference to the scoring standards in table 4, and the average value of the scores of 30 observers was recorded in table 5.
TABLE 4 scoring results
| Scoring index | Scoring |
| Uniform, fine, no layering and aggregationOr precipitate out | 30.5 to 40 minutes |
| The solution showed a few insoluble particles | 20.5 to 30 points |
| The solution is layered and insoluble particles are separated out | 10.5 to 20 minutes |
| Obvious layering of the solution occurs and a large amount of insoluble particles are separated out | 0 to 10 minutes |
Table 5 stability test of skin lotions
As can be seen from the data in table 5, the skin moisturizers prepared by adding the moisturizing particles and the rheology modifiers in examples 5 and 8 to 10 did not cause the precipitation of insoluble particles after standing at room temperature, and were stable.
In example 11, the same amount of nano titanium dioxide was used instead of modified titanium dioxide, and the data in table 5 shows that the skin lotion prepared in example 11 was rated below 30 minutes after being left for 3 months, and a few particles were precipitated.
In example 12, without the addition of rheology modifier, compared to example 9, it is shown in table 5 that the score is significantly lower than that of example 9 at 1 month of storage, and after 3 months of continuous storage, the score is reduced by 25.2 points, with poorer stability.
In example 13, the pH was adjusted to 7, the stability of the skin lotion was not much different from that of example 9, and insoluble particles were not precipitated.
The moisturizing particles are also pretreated compared with the moisturizing particles in example 9 in examples 14 and 15, and the skin care lotion prepared in examples 14 and 15 has no particles, no layering and precipitation, higher evaluation score and better stability after being continuously placed.
In examples 16 and 17, when the moisturizing particles were pretreated, the evaluation scores of the lotions were reduced compared to example 15 without the treatment with PLGA and sorbitan fatty acid ester, respectively.
Fourth test, sunscreen Effect test
4.1 test sample: skin lotions prepared according to example 1 and examples 4 to 11.
4.2 subjects: 80 volunteers, divided into 8 groups of 10 persons each.
4.3 test methods: testing by adopting an international general human body efficacy test and evaluation method and an in-vitro machine test method, referring to the 2015 edition of cosmetic safety technical specification, wherein the instrument is an SPF-290AS sun protection factor measurement system of Solar Light company; the solar simulator xenon arc lamp is used as a light source for testing, ultraviolet rays with the wavelength of 290-400nm are continuously generated to irradiate the back, a forward leaning position or a prone position can be adopted, the skin care water prepared in each embodiment is correspondingly coated on the back of each group of volunteers, and the area is not less than 30cm2At a ratio of 2mg/cm2Weighing samples, uniformly coating skin care water in a back test area by using a latex finger cot, irradiating 5 points with ultraviolet rays with different doses, sequentially increasing the irradiation dose or time amplitude, observing results after 24 hours, taking the minimum irradiation dose or the minimum irradiation time of erythema on the skin as the minimum erythema dose MED of the normal skin of a testee, obtaining unprotected skin MED and MPPD by adopting the same method, and calculating the sun protection factor PFA and the protection factor according to the following formulas: sun Protection Factor (SPF) refers to skin MED with skin lotion/skin MED without skin lotion; PFA (protection factor) was skin MPDD with skin lotion applied/skin MPDD without skin lotion applied, and the test results were averaged for each group and recorded in table 6.
TABLE 6 sunscreen test of lotions
The data in table 6 show that the skin moisturizer prepared in example 1 has poor sunscreen effect and needs to have improved UVA protection performance, while the skin moisturizers prepared in examples 4 and 5 with moisturizing particles have improved sunscreen effect, while the skin moisturizers prepared in examples 6 and 7 without adding the lotus petiole extract and the sunflower root ferment have reduced sunscreen effect and reduced UVA protection performance compared with example 5.
In examples 8 and 9, the SPF value of the skin moisturizers prepared in examples 8 to 9 was increased and the sunscreen effect was enhanced compared to example 5 by adding modified titanium dioxide to the wall material of the moisturizing particles.
Example 10 compared to example 9, when modified titanium dioxide was prepared without adding sophora flower extract, the SPF value and PFA value of skin moisturizer were reduced, and the sunscreen effect was reduced.
Compared with example 9, the sun-screening effect is remarkably reduced and the protective performance to UVA is reduced by using the nano titanium dioxide instead of the modified nano titanium dioxide in example 11.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The soothing moisturizing skin care lotion is characterized by comprising the following components in parts by weight: 1-2 parts of purslane extract, 0.1-0.5 part of zinc gluconate, 0.08-0.1 part of preservative, 1-2 parts of humectant, 0.25-0.4 part of hydrolyzed collagen, 1-2 parts of honey extract, 0.1-0.5 part of copper gluconate, 0.5-1 part of glycol and 70-80 parts of water;
the humectant comprises hyaluronic acid, magnesium aspartate and panthenol in a mass ratio of 1 (0.3-0.5) to 0.1-0.3.
2. The soothing moisturizing lotion of claim 1, wherein the moisturizer comprises hyaluronic acid, magnesium aspartate, and panthenol in a mass ratio of 1:0.3: 0.3.
3. The soothing moisturizing lotion of claim 1, wherein: the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol with the mass ratio of 1 (0.5-1).
4. The soothing moisturizing lotion of claim 1, wherein: the soothing moisturizing lotion also comprises 0.5-1.5 parts by weight of moisturizing particles and 0.1-0.5 part by weight of rheology modifier, wherein the moisturizing particles comprise wall materials and core materials in a mass ratio of 1: 0.5-0.7;
the wall material comprises the following components in parts by weight: 1-2 parts of soybean protein, 1-2 parts of maltodextrin, 0.5-1 part of lotus petiole extracting solution, 0.5-1 part of sunflower root leavening, 0.1-0.15 part of flaxseed gum and 1-1.5 parts of water;
the core material is one or more of vegetable oil, animal oil and mineral oil.
5. The soothing and moisturizing skin lotion as claimed in claim 4, wherein the lotus petiole extracting solution is prepared by the following method: cleaning lotus petiole, cutting, heating in distilled water to 80-100 deg.C, maintaining the temperature for 5-8h, performing ultrasonic treatment at power of 2000-.
6. The soothing and moisturizing skin lotion according to claim 4, wherein the sunflower root ferment is prepared by the following method: cleaning sunflower roots, drying, crushing, adding water, dry yeast and honey, uniformly mixing, sealing, fermenting for 15-25 days, sterilizing, centrifuging, and extracting by supercritical carbon dioxide fluid to obtain a sunflower root fermented product, wherein the mass ratio of the sunflower roots to the dry yeast to the honey is 1:0.2-0.3: 0.005-0.01.
7. The soothing and moisturizing skin lotion as claimed in claim 4, wherein the wall material comprises 0.5-1 part by weight of modified titanium dioxide particles, and the modified titanium dioxide particles are prepared by the following method: adding nanometer titanium dioxide particles into the mixed solution containing paraffin, petroleum ether and flos Sophorae Immaturus extract, stirring, heating in water bath to 65-70 deg.C, and evaporating petroleum ether to obtain modified titanium dioxide.
8. A soothing moisturizing lotion according to any one of claims 4 to 7, wherein the moisturizing particles are prepared by a method comprising: mixing soybean protein and maltodextrin, adding flaxseed gum, water, lotus petiole extract, sunflower root ferment and modified titanium dioxide particles to prepare a wall material, uniformly stirring the wall material and a core material, homogenizing, and performing spray drying to prepare the moisturizing particles.
9. A soothing moisturizing lotion according to claim 8, wherein the moisturizing particles are pretreated by: adding the moisture-keeping particles into 1-4% PLGA ether solution, mixing, adding 1-4% sorbitan fatty acid ester ether solution, ultrasonic stirring at 35-40 deg.C, and spray drying.
10. A method of preparing a soothing moisturizing lotion according to any one of claims 1-3 or 9, comprising the steps of:
uniformly mixing the purslane extract, zinc gluconate, the honey extract, the humectant and copper gluconate, stirring and heating to 70-80 ℃ to obtain a material A;
mixing hydrolyzed collagen, antiseptic and hexanediol, heating to 60-70 deg.C to obtain material B, mixing material B and material A, adding moisturizing granule and rheology modifier, and homogenizing to obtain soothing moisturizing skin care lotion.
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