JPS59139310A - Emulsified composition - Google Patents

Abstract

PURPOSE:An emulsified composition, containing chitosan, a glycol derivative of the chitosan or/and a salt thereof and further a water-soluble polyhydric alcohol and oily comonent, and having high safety as a cosmetic, medicine and food, etc., fine particle diameter and good stability. CONSTITUTION:A uniform and stable emulsified composition obtained by incorporating one or more selected from chitosan known as a hihgly safe natural water-soluble high polymer extracted from animals or plants such as lobsters or shirmps, fungi, algae, etc., a glycol derivative of the chitosan and a salt thereof as an emulsifying agent with further a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule and an oily component. The above-mentioned composition is a transparent or semitransparent viscous liquid or gel, and a milky white stable oil-in-water type emulsified composition containing very fine dispersed particles is obtained by adding water thereto.

Description

[Detailed Description of the Invention] The present invention aims to effectively utilize a conductor as an emulsifier in cosmetics, medicines, and the like.

In recent years, much research has been carried out on emulsification, a large number of emulsifiers have been developed, and emulsification technology has made remarkable progress, and the extremely stable Emulsi G/ has been widely used in all industries. However, most of them use nonionic surfactants containing polyoxyethylene chains, anionic surfactants such as fatty acid soaps, cationic surfactants, and amphoteric surfactants as emulsifiers, especially for general consumption. Many people have concerns about safety.

Under these circumstances, the use of biologically derived substances with surfactant ability has been considered, but since chitosan and chitosan glycol derivatives are polymeric substances, generally when used as an emulsifier, emulsified particles are It was not possible to make it very fine.

In view of these circumstances, the present inventors conducted intensive research to effectively utilize chitosan or chitosan glycol derivatives, which are natural polymeric substances with high human safety, as emulsifiers, and as a result, dissolved acyl peptides in polyhydric alcohol. death,
It was discovered that if an oil component was added to this, it was possible to produce emuls/feces with fine particle size and good stability, and the present invention was completed.

That is, the present invention provides one or more selected from the group consisting of chitosan and its salts, chitosac glycol derivatives and its salts, and a water-soluble polyhydric alcohol having 2 to 7 hydroxyl groups in the molecule. and an oil component, and a stable oil-in-water emulsion composition having uniform and fine emulsion particles obtained by further adding water to this emulsion composition.

The emulsion composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsion composition to which water is added is a milky-white fine-particle emul/dino.

The reason for this fine particle formation is thought to be that the chitosan extract or its salt, or the chitosac glycol derivative, or its salt, is effectively oriented and interacts with the polyhydric alcohol-oil interface.

Next, the configuration of the present invention will be explained in detail.

The water-soluble polyhydric alcohol used in the present invention is a water-soluble polyhydric alcohol containing two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and 14-butylene. Glycol, cyfropyrene glycol, glycerin, and polyglycerin such as diglycerin, triglycerin/tetraglycerin, glucose, maltose, maltitol, sucrose, fructose, quinlitol, sorbitol, malt l-'J ose, threitol, erythritol, These include starch-decomposing sugar ring alcohols, and one or more of these may be used.゛The blending amount is 2 to 95% by weight of the emulsified composition consisting of chitosan and its salts, one kind selected from chitosan glycol derivatives and their salts, two or more kinds of I'i, a polyhydric alcohol, and an oil phase.
Hereinafter, it will simply be referred to as %. ).

Chitosan used in the present invention is extracted from plants and animals such as shrimp, crabs, fungi, and algae. There are various extraction methods, and Chitosa extracted by any method can be suitably used in the present invention.Next, general examples of extraction methods are shown.

After washing shrimp and crab shells with water, carnoum carbonate is removed with dilute hydrochloric acid, and then heated in an aqueous sodium hydroxide solution to decompose and remove proteins.

By repeating this alkaline treatment several times with the finely powdered sample, pure white chitin powder can be obtained. When this chitin is heated in a concentrated alkali, chitosa/ is obtained through a deacetylation reaction.

Next, the chitosac glycol derivatives used in the present invention are glycol chitosan obtained from an alkaline aqueous solution of chitosan and ethylene oquinide, and methyl glycol chitosan obtained by further methylating this.

Chitosan extract or chitosan glycol derivative has molecular weight IQ
00 Dalt/or more can be suitably used.

Substances that form salts of chitosan and chitosan glycol derivatives include inorganic acids such as hydrochloric acid, sulfuric acid, and nitric acid;
Organic acids such as acetic acid, citric acid, maleic acid, and sodium fumarate; acidic amino acids such as glutamic acid and aspartic acid;
and oligopeptides containing these are used, and organic and inorganic salts containing the above acid ions are also used.

The salt of chitosa/or chitosan glycol derivative may be reacted in advance to form a salt and then added, or may be added separately and reacted to form a salt during the manufacturing process of the emulsion composition. The pH of the aqueous salt solution of chitosan or chitosan glycol derivative is preferably 9 or less.

The blending amount of one or more selected from chitosan and its salts, and chitosac glycol derivatives and its salts and the polyhydric alcohol is in the range of 11 to 1000 in terms of weight ratio. If the amount of polyhydric alcohol is less than 11, the solubility of chitosan, chitosac glycol derivatives, etc. will be poor, and if it exceeds 1000, emulsion stability will be poor.

The oils used in the present invention include animal and vegetable oils and fats and hydrocarbons such as beef tallow, sow flour, olive oil, and rice bran oil, liquid paraffin, mineral oils such as petrolatum, inopropyl myristate, pentaerythritol-tetra-2-ethylhexano Cosmetics, such as ester oils such as ate, vitamin A palmitate, vitamin E acetate, methylphenyl silico/, dimethyl silico/licon oil, etc.
It is an oil commonly used in the pharmaceutical, food, and other industries.

It is desirable to adjust the total amount of polyhydric alcohol and one or more of chitosan and its salt, and chitosan glycol derivative and its salt to be 20% or more based on the oil content.

In addition to the above-mentioned essential components, the emulsified composition according to the present invention may include nonionic surfactants, anionosurfactants, cationic surfactants, amphoteric surfactants, drugs, ultraviolet absorbers, Preservatives, antioxidants, etc. may be mixed and added. However, alcohol, fatty acids, other water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization and viscosity adjustment.

To obtain the emulsified composition of the present invention, one or more of chitosan and its salts, and chitosan glycol derivatives and its salts are dissolved in an aqueous solution of a polyhydric alcohol, and an oil component is added while stirring. It can be obtained by In this case, it is preferable to perform a homomixer treatment, but a good emulsified composition can be obtained even with a weak stirring force such as manual stirring.

The emulsified composition obtained here is a uniform, transparent or translucent gel or viscous liquid, so it can be used as is, for example, sun care jelly, beauty serum, edible serum IJ-1 medicated jelly, pine surge jelly, It can be used in all fields, including lubricating oils, cosmetics, medicine, and feed.

The oil-in-water emulsion composition according to the present invention can be obtained by mixing the emulsion composition described above and water.

In this case, it is desirable to perform homomixer treatment.

The oil-in-water type composition obtained here has extremely excellent stability.

Depending on the purpose, water phase components commonly used in the cosmetics, pharmaceutical, food, and other industries may be added to the water, such as wetting agents, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, and water-soluble polymers. You can also do it.

The quantitative relationship between the emulsified composition and water can be selected from a very wide range, but it is usually 99.5 to 20 parts of water to 05 to 80 parts of the emulsified composition.

The oil-in-water emulsion composition obtained here is a milky-white viscous or low-viscosity liquid in which uniform fine particles are dispersed, so it can be used in cosmetics such as emulsions, creams, and cosmetics even in its original form. It can be suitably used in all fields such as toiletry products such as , /ya/boo and Rinos, pharmaceuticals such as urea cream and acne cream, and foods such as mayonnaise. However, there is no problem in adding other water-soluble polymers, drugs, surfactants, powders, etc. to stabilize homogeneity, adjust viscosity, or impart medicinal effects.

Hereinafter, the present invention will be explained in more detail with reference to Examples and Comparative Examples. The present invention is not limited thereby.

Examples 1 to 9, Comparative Examples 1 to 3 Chitosan and chitosan glycol derivative salts, polyhydric alcohols, purified water, and oil were blended in the composition and amounts shown in Table 1, and 70" (treated with a homomixer) An emulsified composition was prepared.Furthermore, 10 times the amount of water was added to this emulsified composition while stirring at room temperature to prepare an oil-in-water emulsified composition.

The states of the emulsified composition and oil-in-water composition were observed, and their characteristic values were measured, and the results are shown in Table 1. Note that the numbers for each component are weight %.

Table-1 (Blend amount is weight %) Table-1 (Blend amount is weight %) Table-1 (Blend amount is weight %) Table-1 (f) Condition of oil-in-water emulsion composition after standing for 1 day Judgment was made based on the following criteria.

◎ Emulsified particle size 1 μ or less 0 1 to 5 μ △ 5 to 1 O μ A stable emulsified composition was not obtained in Comparative Example 2, where water was used as an external phase and Ty was used. Furthermore, even if salts of chitosan and chitosan glycol derivatives, polyhydric alcohols, and oil were included, a stable emulsified composition could not be obtained if the polyhydric alcohol was compensatingly small (Comparative Example 3).

On the other hand, for Examples 1 to 9 according to the present invention,
At any level, a very good transparent or translucent viscous liquid or gel is obtained, and the oil-in-water emulsion composition obtained by adding water is stable with very fine particles dispersed. It was an emulsion.

Example 10 Aqueous cosmetic oil (% by weight) (A) Methyl glycol chitosan aspartate 2-0 maltitol (70% aqueous solution)
30.01.3-Butylene glycol 10.0 Ascorpinoic acid o5(B) Liquid paraffin 300 Olive oil 208
Glyceryl tristearate 50
Vitamin E acetate 05 Vitamin A palmitate 0.5 Preservatives 05 Fragrance
The 02fAl phase was thoroughly stirred at 70' (B)
The phases were dissolved at 70°C and added to phase (A) with stirring. The kernels were treated with a homomixer, stirred and cooled to obtain an aqueous cosmetic oil. This cosmetic oil has a viscous, slightly fluid, transparent gel-like appearance, and is an emulsion that is highly safe for the skin and has excellent stability over time.When applied to the skin, it spreads very easily and in small amounts. It had a wide range of usage characteristics.

Example 11 Emulsion (wt%) (A) Pharmacopoeia glycerin
20.01.3-Butylene glycol
50 chitosan hydrochloride
2-0 Glycol Kitosa/1.0 Ara/Toy 102 Citric acid 0.1f
Bl liquid paraffin
10.0 olive oil
50 Pentaerythritol-tetra-2-ethylhexanoate 5.0 Petrolatum 7 5. Q Ethinylestradiol 0.1 Preservative
04 Fragrance
0.3 (0) Purified water 456 Kisa/Tengum 01 Kizuna extract F2i, 0.1 Oriental japonica extract 01 According to the manufacturing method of Example 1O, an emulsion composition was obtained from the French) phase and (I]) phase, 70'C: and adjust separately to 70''CK
After diluting and dispersing with the retained thickener aqueous solution (c) phase,
It was cooled to obtain an oil-in-water type nutritional emulsion. The viscosity of this emulsion was 79,000 PS at 30°C, and the emulsion had a stable emulsion particle size of about 1 to 3 μm and a familiar feel.

Example 12 Suncare cream (wt%) Head Diglyceride 720.0 Norpitot/l/(70% water soluble 1vL)
a.

Glucose (50% aqueous solution) 40 Glycol chitosan hydrochloride 2-0 Glucosamine hydrochloride 05 (B
) Fluid Balafi 7
20.0 innopropyl myristate
10.0 Waseri 7
5. Q Nutearyl alcohol
50P A B A
20 Preservatives 05 Flavors
0.3ta+purified water 195 Hitoroki/Ethyl cellulose 02f
D) Mixed powder 1.0 Titanium dioxide 20 A sun care cream was obtained according to the manufacturing method of Example 11. At this time, the (0) phase was used as a diluted phase after subjecting the CDI phase to a dispersion homomixer treatment at 70°C.

This sun care cream has a hardness of 23 at 25°C, is slightly transparent, and has a highly stable oil-in-water emulsion composition with a trench emulsion particle size of approximately 1 to 3 liters. It was suitable for use.

patent applicant Shiseido Co., Ltd.

Claims (2)

[Claims] (1) One or more selected from the group consisting of chitosan and its salts, and chitosan glycol derivatives and its salts, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil component. An emulsified composition comprising: (2) One or more selected from the group consisting of chitosan and its salts, and chitosan glycol derivatives and its salts, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil component. an emulsifying composition comprising;
An oil-in-water emulsion composition containing water.