JPS61227517A - Skin cosmetic - Google Patents

Abstract

PURPOSE:A skin cosmetic having improved feeling in use free from skin irritation, blending a slightly water-soluble cosmetic component with a cyclodextrin polymer in the form of an inclusion compound of it with the cyclodextrin polymer. CONSTITUTION:A slightly water-soluble cosmetic component (e.g., natural animal or vegetable fats and oils such as olive oil, mink oil, jujube oil, lanolin, hydrocarbon such as liquid paraffin, squalane, etc., wax such as whale wax, bees wax, etc., higher alcohol such as cetanol, etc., higher fatty acid, etc. such as myristic acid, etc., silicone oil, etc.) is blended with a cyclodextrin polymer [having >=20 water-solubility in 100ml water at 25 deg.C; preferably compound shown by the formula (n is 3-4)] in the form of an inclusion compound of it and the cyclodextrin polymer, to give a cosmetic for the skin wherein a large amount of the slightly water-soluble cosmetic component is uniformly blended. The amount of the cosmetic component used is 0.001-0.5pt.wt. based on 1pt.wt. cyclodextrin polymer and the treatment temperature is 10-70 deg.C.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to a skin cosmetic composition containing sparingly water-soluble or water-insoluble cosmetic ingredients in the form of an inclusion compound with a water-soluble cyclodextrin polymer.

[Prior art]

Generally, it is used in skin cosmetics for the purpose of oil replenishment.

Oil-based substances such as fats and oils and hydrocarbons, oil-soluble physiologically active substances with excellent dermatological effects, and fragrances are used to enhance usability. On the other hand, from the viewpoint of usability, there are many cosmetics that are mainly water-based, such as lotions, low-viscosity emulsions,
There are body lotions etc. In recent years, such water-based products have been combined with fat-soluble vitamins such as vitamins A, E, and D to enhance their effects on the skin, and large amounts of fragrances have been added to make body lotions with scents. It is desirable to incorporate However, since such cosmetic ingredients are oil-soluble and poorly water-soluble, it has been difficult to incorporate them in large amounts into aqueous-based skin cosmetics. Therefore, in order to uniformly mix a poorly water-soluble substance into an aqueous base.

Surfactants and solvents such as ethanol and polyols are used as solubilizers.

However, in such cases, there have been problems such as the surfactant causing irritation to the skin and the use of a solvent impairing the original feel of the skin cosmetic.

On the other hand, a method of making water-soluble substances water-soluble by utilizing the inclusion effect of cyclodextrin, which is a cyclic oligosaccharide, is being actively researched. Cyclodextrins are currently
Three types of homologues (α, β, and γ forms) are used. Among them, β-cyclodextrin is the most widely used because it is easily available and clathrates various substances. However, the β-body.

Due to its low solubility in water, its solubilizing effect is limited, and it has been a roundabout way to solubilize the substance to be solubilized at a high concentration and incorporate it into products.

〔the purpose〕

The present inventors have discovered that a cyclodextrin polymer obtained by cross-linking cyclodextrin with, for example, epichlorohydrin, has the inherent inclusion ability of cyclodextrin, and that the polymer with a low degree of polymerization is water-soluble and can be used with water and any desired material. As a result of intensive study based on the empirical fact of mixing in proportions, we found that by pre-mixing this polymer with a poorly water-soluble cosmetic ingredient and making this cosmetic ingredient a clathrate compound, a large amount of the polymer can be mixed in the product. The present invention was developed based on the discovery that the cosmetic ingredients can be uniformly blended.Therefore, an object of the present invention is to provide a skin cosmetic containing a large amount of sparingly water-soluble cosmetic ingredients uniformly blended therein.

〔composition〕

The present invention provides an aqueous-based skin cosmetic composition containing a poorly water-soluble cosmetic ingredient in the form of an inclusion compound with a cyclodextrin polymer.

The cyclodextrin polymer used in the present invention is a conventionally known substance produced by crosslinking cyphlobuxtone with epichlorohydrin, and is represented by the following formula.

The cyclodextrin polymer used in the present invention includes:
Solubility in water is 2 for 100 mfi of water at 25°C.
It is preferable that the polymerization degree is 0 g or more, and for this purpose, it is preferable that the degree of polymerization n in the above chemical formula is 3 to 4. The smaller n is, the higher the water solubility and solubilization effect of the cyclodextrin polymer itself.

The poorly water-soluble cosmetic ingredient used in the present invention means a cosmetic ingredient that is substantially completely insoluble in water or only slightly soluble in water. Specific examples include natural animal and vegetable oils such as olive oil, mink oil, jojoba oil, lanolin, and squalene; hydrocarbons such as liquid paraffin, paraffin wax, and squalane; and whale oil. Waxes such as wax and beeswax; Higher alcohols such as cetanol, incetanol, suataryl alcohol, and instearyl alcohol; myristic acid,
Higher fatty acids such as palmitic acid, stearic acid, behenic acid, isostearic acid; isopropyl myristic acid,
Examples include esters such as isopropyl palmitic acid and isopropyl isostearic acid, as well as silicone oil and the like. Furthermore, vitamins such as vitamin A, vitamin D, vitamin E, 1-copherol acetate, ascorbic acid, and palmitic acid ester; and vitamin-like active substances such as γ-oryzanol and folic acid; estradiol benzoate, estradiol valerate, and ethinyl estradiol. , prostaglandin.

Hormones such as testosterone propionate; UV absorbers such as ρ-aminobenzoic acid ester and phenyl salicylate; other physiologically active substances such as guaice azulene and glycyrrhetinic acid; Oil Red xO (red No. 5), naphthol yellow S (yellow No. 1), tartrazine (yellow No. 4)
Examples include oil-soluble pigments such as No.), and fragrances. These components may be used alone or in the form of a mixture of two or more.

In order to produce the above-mentioned clathrate compound of poorly water-soluble cosmetic ingredients, necessary cosmetic ingredients may be added to and mixed with an aqueous solution of a cyclodextrin polymer.

In this case, the concentration of the cyclodextrin polymer aqueous solution is about 5 to 80% by weight, preferably about 20 to 40% by weight, and the proportion of the cosmetic ingredients used is 0.001 to 0.00% to 1 part by weight of the cyclodextrin polymer. 5 parts by weight, preferably 0.01 to 0.15 parts by weight. The processing temperature is 1
The temperature is 0 to 70°C, preferably 30 to 50°C. Through this treatment, an aqueous solution of a poorly water-soluble cosmetic component and a cyclodextrin polymer clathrate compound is obtained, and this is used as an additive component to the aqueous base.

In addition to the above-mentioned ingredients, the skin cosmetic of the present invention may contain other cosmetic ingredients such as viscosity modifiers, humectants, medicinal agents, preservatives, fragrances, pigments, etc., depending on the purpose of the product. be able to. In this case, the viscosity modifier used is, for example, a polymeric substance such as hydroxyethyl cellulose, cationized cellulose, methyl cellulose, carboxymethyl cellulose rimam, gelatin, etc., and the humectant used is, for example, glycerin, propylene glycol, dipropylene glycol. , 1.3-butylene gellicol, sorbitol, sodium pyrrolidonecarboxylate, etc. are used, and as medicinal agents, for example, water-soluble vitamins such as vitamin B group, allantoin, etc. are used, and as preservatives, for example, Methyl, ethyl paraoxybenzoic acid,
Propyl or butyl ester, benzoic acid or its salt, sorbic acid or its sodium salt, etc. are used.

In the skin cosmetic of the present invention, the inclusion compound of the poorly water-soluble cosmetic acid and the cyclodextrin polymer is at least 0.1% by weight, and the content of the poorly water-soluble cosmetic component is o. It is preferable to add it in an amount of oot weight % or more.

(Effects) Although the skin cosmetics of the present invention are aqueous-based, they uniformly contain a large amount of poorly water-soluble cosmetic ingredients or oil-soluble substances, which were conventionally difficult to incorporate. The effect of adding the oil-soluble substance can be fully exhibited.

The skin cosmetics of the present invention have no skin irritation and have the excellent feeling of use inherent to water-based skin cosmetics, and can be used as lotions, low-viscosity milky lotions, body lotions, and the like.

〔Example〕

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 [Lotion with stable combination of oil-soluble emollient and fragrance]
A liquid floral fragrance 0.2 part β-
Cyclodextrin polymer 2.0II water
8
, QnB liquid isopropyl palmitate 1.0 part β-
Cyclodextrin polymer 9.0 water
20.0
#C liquid glycerin 7.0 parts Ethanol 10.0 #Methyl benzoate 0.1//Citric acid
o. llI Sodium Citrate o. 1. Water
42.5//β
-Dissolve 2.0 parts of cyclodextrin polymer (3 parts tetramer) in 8.0 parts of water, add 0.2 parts of floral fragrance, stir, and solution of fragrance/cyclodextrin polymer complex (clathrate compound). I played A.

In addition, an isopropyl palmitate/cyclodextrin polymer conjugate solution B was prepared in the same manner as in Solution A except that the fragrance was replaced with isopropyl palmitate.

Next, liquid A and liquid B were added to the solution C to obtain a lotion stably containing an emollient and a fragrance. It should be noted that when the cyclodextrin polymer is removed from the above composition, the fragrance and isopropyl palmitate separate, resulting in a lotion that is not uniform and easy to use.

Example 2 [Body lotion with stable blend of anti-inflammatory agent] Liquid A glycyrrhetinic acid/cyclodextrin polymer complex (contains 2% v/w glycyrrhetinic acid) 1.0 part water
3.0
〃B liquid fragrance/cyclodextrin polymer complex (
Contains 5% w/v fragrance) 2.0 parts water
5.0nC liquid ethanol 20.0 parts 1
．． 3-Butylene glycol 8. OII water
61. OII dye trace amount β-cyclodextrin polymer (tripartite tetramer) 0
．． 98 parts by weight were dissolved in 3.0 parts of water, and 0.02 parts of glycyrrhetinic acid was added and stirred to obtain a glycyrrhetinic acid/cyclodextrin polymer composite solution^.

In addition, a perfume/cyclodextrin polymer complex solution B was prepared in the same manner as in Solution A except that glycyrrhetinic acid was replaced with a perfume.

Next, liquids A and B were added to liquid C to produce a body lotion stably containing an anti-inflammatory agent and fragrance. In addition, when the above-mentioned composition is removed from the cyclodextrin polymer, the glycyrrhetinic acid and fragrance are separated and the composition is not uniform, so that it does not always exhibit the same effectiveness when used.

Example 3 [Aftershave lotion with a stable blend of fungicides]
Part A triclosan/cyclodextrin polymer complex (contains triclosan 10%/%1) 2. o part water
5. QtyB liquid citrus fragrance/cyclodextrin polymer complex (contains 5% fragrance +/w) 2.0 parts water
5.07/C liquid ethanol 35.0 parts polyethylene glycol 5. OII water
46.
0 part dye Trace amount〃β-
1.8 parts of cyclodextrin polymer (3 parts tetramer) and 5 parts of water. The solution was dissolved in θ part, 0.2 part of triclosan was added and stirred to obtain Dorclosan/Cyclodextrin Polymer Complex Solution A.

In addition, a perfume/cyclodextrin polymer composite solution B was obtained in the same manner as in Solution A except that triclosan was replaced with a perfume.

Next, liquids A and B were added to the liquid C to obtain an aftershave lotion in which a disinfectant and fragrance were stably blended. In addition, in the above-mentioned composition from which Schiflobukis 1 Herrin Polymer is removed, the triclosan and fragrance are separated and the uniformity is lost, so the same effectiveness is not always exhibited during use, and long-term storage ( (6), discoloration due to triclosan occurred and stability also deteriorated.

Claims (3)

[Claims] (1) A skin cosmetic comprising a poorly water-soluble cosmetic ingredient in the form of an inclusion compound with a cyclodextrin polymer. (2) The cyclodextrin polymer used has a solubility in water at 25°C of 5 g/100 ml or more, and the cyclodextrin polymer content is 0.1
% or more by weight of the skin cosmetic according to claim 1. (3) The skin cosmetic according to claim 1 or 2, wherein the cosmetic component is an oil-soluble substance.