JPH10203955A - Antimicrobial low-irritating cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic having excellent antimicrobial action, not exhibiting primary irritation and sensitization, and also not giving stabbing pain or unpleasant feeling such as irritating sensation or pricking sensation. SOLUTION: This antimicrobial and low-irritating cosmetic is obtained by combinedly using and including an extract of one or two or more kinds of plants selected from plants of the genus Tilia, especially Tilia cordata Mill., Tiliaulmifolia Scop. or Tilia parvifolia Ehrh., Tilia platyphyllos Scop. or Tilia grandifolia Ehrh. and Tilia europaeaL., with one or two or more kinds of substances selected from a polyhydric alcohol and an alkyl ether of polyhydric alcohol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and mold, is stable and has low skin irritation. More specifically, one or more selected from polyhydric alcohols and alkyl ethers of polyhydric alcohols,
The present invention relates to a low anti-irritant cosmetic having a high antibacterial property, which is obtained by using an extract of a genus Linus.

[0002]

2. Description of the Related Art Conventionally, cosmetics containing water, such as lotions, emulsions, creams, etc., have various antibacterial and antibacterial properties in order to prevent deterioration due to the incorporation of microorganisms such as bacteria and fungi during production and use. Fungicides have been used. Examples of such antibacterial and fungicidal agents include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol, benzoic acid and its salts, salicylic acid and its salts, dehydroacetic acid and its salts, sorbic acid and its salts. Acids, quaternary ammoniums such as benzalkonium chloride, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned fungicides and fungicides have been reported as having primary irritation, sensitization or photosensitization to the skin. In many cases, an amount showing an effective antibacterial activity cannot be blended. Further, even when the cosmetic does not show a stimulating or sensitizing reaction such as redness, rash or edema to the skin, it may cause discomfort such as stabbing pain, burning, or tingling when using the cosmetic. Are known. In addition, due to the interaction with the base of the cosmetic or other compounding components, there may be cases where sufficient antibacterial activity is not exhibited.

For example, isopropylmethylphenol,
When an oil-soluble antibacterial and fungicide such as paraoxybenzoate and sorbic acid is added to a cosmetic containing a polymer thickener or powder, the antibacterial activity is reduced by adsorption or the like. Further, in cosmetics containing a surfactant, the antibacterial activity is also reduced due to incorporation into surfactant micelles.
On the other hand, if a large amount is added in anticipation of a sufficient antibacterial activity, problems such as crystal precipitation at low temperatures and the like arise in product stability.

[0005] Water-soluble germicides such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. Becomes stronger, the solubility in water decreases,
Crystal precipitation may occur.

[0006] Further, quaternary ammoniums and amphoteric surfactants are irritating to the skin and mucous membranes of the eyes, and are liable to foam, and the antibacterial activity decreases on the acidic side.
There are practical problems such as interaction with anionic substances.

[0007]

Accordingly, in the present invention, an effective antibacterial action is exhibited without deteriorating the antibacterial activity by the cosmetic base or other compounding ingredients. By reducing the blending amount, a cosmetic is obtained that not only does not show primary irritation or sensitization to the skin, but also does not cause discomfort such as stinging, burning, or tingling when using the cosmetic. It was aimed at.

[0008]

In order to solve the above problems, a study was made on a fungicidal and fungicide system having high stability and low irritation to the skin. By combining one or more selected from the extract of the genus Lindus in combination with the extract, not only the antibacterial activity is synergistically improved,
It has been found that irritation and discomfort to the skin are significantly reduced, and the present invention has been completed.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, any polyhydric alcohol which is usually used as a raw material for cosmetics can be used. In particular, those having 4 or less hydroxyl groups in the molecule have a synergistic antibacterial activity. It is preferable for obtaining. For example, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol (isopropylene glycol), hexylene glycol, glycerin, diglycerin, etc. And one or more of these are selected and used.

As the alkyl ether of a polyhydric alcohol used in the present invention, glycols or alkyl ethers of glycerin can be preferably used.
Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether (ethyl eserosolve), ethylene glycol monobutyl ether (butyl cellosolve), ethylene glycol dimethyl ether, diethylene glycol monomethyl ether (methyl carbitol), diethylene glycol monoethyl ether (ethyl carbitol), diethylene glycol monobutyl ether , Diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, glyceryl monopalmityl Ether (Kimi alcohol),
Glyceryl monostearyl ether (batyl alcohol), glyceryl monooleyl ether (serakyl alcohol) and the like are exemplified as preferable ones, and one or more of these are selected and used.

These polyhydric alcohols or alkyl ethers of the polyhydric alcohols alone exhibit antibacterial activity at 5.0% by weight or more, but when added to complex systems such as cosmetics, have a sufficient antibacterial activity. Is often not recognized. However, in the present invention, synergistic enhancement of the antibacterial activity is recognized, and a sufficient antibacterial effect is exhibited at a blending ratio of about 5.0 to 10.0% by weight.

[0012] In the present invention, Tilia plants in combination with alkyl ether of a polyhydric alcohol or a polyhydric alcohol, a kind of Tiliaceae plants (Tiliaceae), American linden (Tilia americana L.), Tilia cordata (Tilia
cordata Mill., Tilia ulmifolia Scop., Tilia parvi
folia Ehrh.) European linden ( Tilia europaea )
L.), linden ( Tilia japonica (Miq.) Simonk.), Herring tree ( Tilia kiusiana Makino et Shiras.), Squid ( Tilia maximowicziana Shiras.), Bodaiju ( T
ilia miqueliana Maxim.), Natsubodaiju ( Tilia plat
yphyllos Scop., Tilia grandifolia Ehrh.) and the like.

[0013] The linden plants such as Bodaiju are widely used as folk medicine in Europe. The essential oil obtained from the dried inflorescence is used as a sweat, an antispasmodic or a bathing agent. It has been used for burns and wound healing.

The extraction site of the extract of the linden plant is not particularly limited, but the bark and its mucus, fruit,
Examples include seeds, flowers, branches and leaves, and among them, extracts of linden flowers are most preferred from the viewpoint of antibacterial action.

When an extract is obtained from these plants, the plants can be extracted raw or in a dry state. However, from the viewpoint of odor and storage stability, it is necessary to use the dried product as it is or after pulverizing it. preferable.

Solvents for obtaining these plant extracts include water, ethanol, methanol, isopropanol,
Alcohols such as isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene Glycol monoethyl ether, triethylene glycol,
Polyhydric alcohols such as 1,3-butylene glycol and hexylene glycol or derivatives thereof, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; esters such as ethyl acetate and isopropyl acetate; ethyl ether One or a mixture of two or more polar solvents such as ethers such as isopropyl ether, n-butyl ether and the like can be suitably used, but there is no particular limitation. Or petroleum ether, n-hexane, n-pentane, n-butane, n-octane,
One or more mixed solvents of non-polar solvents such as aliphatic hydrocarbons such as cyclohexane, carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, and toluene can also be suitably used.

The solvent from which the extract of the genus Lindenium is obtained is not particularly limited as long as it is the above-mentioned solvent, but from the viewpoint of antibacterial action, a polar solvent is preferred.
One or more mixed solvents of 1,3-butylene glycol and water are preferable, and among them, 50% by weight as an extraction solvent is preferred.
A 1,3-butylene glycol aqueous solution is most preferred.

Further, as an extraction method, a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, an extract by pressing from a raw linden plant And the like. Extraction is performed using these methods alone or in combination of two or more.

The ratio of the plant to the solvent at the time of extraction is not particularly limited.
It is preferably 0 times by weight, especially 5 to 100 times by weight in terms of extraction operation and efficiency. The extraction temperature is conveniently in the range from room temperature to the boiling point of the solvent under normal pressure, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.

In addition, the extract of the genus Lindenium plant thus obtained can be used as it is,
In addition, it can be blended after deodorizing, purifying and the like are added within a range that does not lose the fungicidal and fungicidal action, and can also be used as a fraction using column chromatography or the like. Further, these extracts, deodorized, purified, and fractionated products can be dried by removing the solvent therefrom, and further provided in the form of a solution solubilized in a solvent such as alcohol or in the form of an emulsion. can do. In addition, the compounding amount of the extract of the linden plant in the cosmetic is 0.01 to 10
A concentration as low as about% by weight is sufficient.

The cosmetic according to the present invention can be in any form such as cream, ointment, lotion, emulsion, solid, powder, etc., and basic cosmetics such as lotion, emulsion, serum, moisturizing cream, etc. Sun care products such as sunscreen creams, sunscreen lotions, suntan oils, carmine lotions, foundations, makeup cosmetics such as eyeliner, mascara, eye color, cheek color, lipstick, face wash, body shampoo, hair shampoo, etc. Hair cosmetics such as cleaning agents, rinses, treatments, hair creams, hair oils, hair styling agents, perfumes,
It can be provided in the form of a deodorant and antiperspirant.

At this time, various components generally used in cosmetics, for example, avocado oil, palm oil, peanut oil, rice bran oil, jojoba oil, orange roughy oil, macadamia nut, as long as the effects of the present invention are not impaired. Oil, squalane, evening primrose oil, sesame oil, sunflower oil, safflower oil, carola oil, carnauba wax, paraffin wax, lanolin, diisostearyl malate, isostearyl alcohol, oils such as liquid paraffin, collagen, hyaluronic acid Humectants such as vitamin A oil, retinol, vitamin A such as retinol acetate, vitamin B ₂ such as riboflavin and riboflavin butyrate, vitamin B ₆ such as pyridoxine hydrochloride, L-ascorbic acid and magnesium L-ascorbyl phosphate C, such as sodium and sodium L-ascorbate , Calcium pantothenate, D-pantothenyl alcohol, pantothenic ethyl ether, acetyl pantothenyl ethyl ether, etc., pantothenic acids such as ergocalciferol, cholecalciferol, etc., nicotinic acid, nicotinamide, benzyl nicotinate Nicotinic acids such as α-tocopherol,
Vitamin E such as tocopherol acetate, vitamin P, vitamins such as biotin, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-
Sulfonic acid, 2-hydroxy-4-methoxybenzophenone-
Benzophenone derivatives such as sodium 5-sulfonate; paraaminobenzoic acid derivatives such as paraaminobenzoic acid, ethyl paraaminobenzoate, octyl paradimethylaminobenzoate; 2-ethylhexyl paramethoxycinnamate; mono-2-ethylhexanoic acid diparamethoxycinnamate Methoxycinnamic acid derivatives such as glyceryl; salicylic acid derivatives such as octyl salicylate and myristyl salicylate; urocanic acid;
4-tert-butyl-4'-methoxydibenzoylmethane, 2- (2'-
UV absorbers such as (hydroxy-5'-methylphenyl) benzotriazole, natural plant polysaccharides such as guar gum, locust bean gum, carrageenan, quince seed, pectin, mannan, and microorganisms such as xanthan gum, dextran, curdlan, hyaluronic acid, etc. Animal natural polymers such as gelatin, casein, albumin, collagen, etc., methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose,
Cellulose-based semi-synthetic polymers such as carboxymethyl cellulose, starch-based semi-synthetic polymers such as soluble starch, carboxymethyl starch, and methyl starch; alginic acid-based semi-synthetic polymers such as propylene glycol alginate and alginate; polyvinyl alcohol; polyvinyl pyrrolidone , Carboxyvinyl polymers, synthetic polymers such as sodium polyacrylate and polyethylene oxide; water-soluble polymers such as bentonite, laponite and colloidal alumina; and dibutylhydroxytoluene, butylhydroxyanisole and gallic acid esters. Antioxidants, higher fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, acyl methyl taurine salts, alkyl ether phosphate salts, a Anionic surface active agents such as an arylamino acid salts, alkyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, cationic surfactants such as benzalkonium chloride, alkyl dimethyl amino acetic acid betaine, alkylamido betaine, 2-
Amphoteric surfactants such as alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl Ether, polyoxyalkylene fatty acid glycerin ester, polyoxyalkylene sorbitan ester, sorbite oligomeric tetraester, sorbite oligomeric hexaester, polyethylene glycol ester, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, alkylolamide, Nonionic surfactants such as fatty acid amides,
Sodium ethylenediaminetetraacetate, sodium polyphosphate, citric acid, sodium metaphosphate, succinic acid,
Sequestering agents such as gluconic acid, placental extracts, soybean arbor extract, glutathione, kojic acid and derivatives thereof, whitening agents such as hydroquinone and its derivatives such as hydroquinone glycosides, glycyrrhizic acid, glycyrrhetinic acid, alantoin, azulene , Hydrocortisone, ε
-Anti-inflammatory agents such as aminocaproic acid, astringents such as allantoin hydroxyaluminum, aluminum chloride, tannic acid, citric acid, and lactic acid; fresheners such as menthol and camphor; antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate; estradiol ,
Sebum depressants such as estrone and ethinyl estradiol, exfoliants and dissolving agents such as salicylic acid and resorcinol, α
-Hydroxy acids and the like can be blended.

[0023]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

[Example 1] Lotion (1) Ethanol 0.5 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Glycerin 2.0 (4) Polyoxyethylene hydrogenated castor oil 0 0.6 (5) Botanical linden flower, 50% by weight 1,3-butylene glycol aqueous solution extract 1.0 (6) Fragrance 0.06 (7) Purified water 85.84 Production method: each of (1) to (6) The components are sequentially added to (7) and uniformly mixed to prepare.

Example 2 Emulsion (1) Squalane 4.0 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 2.0 (3) Cetyl 2-ethylhexanoate 3.0 (4) Cetanol 0.6 (5) Stearyl alcohol 0.4 (6) Sorbitan monostearate 1.2 (7) 1,3-butylene glycol 6.0 (8) Dipropylene glycol 4.0 (9) Polyoxyethylene ( (20EO) Sorbitan 0.8 monostearic acid ester (10) Purified water 75.9 (11) Botanical linden flower, 50% by weight aqueous 1,3-butylene glycol extract 2.0 (12) Fragrance 0.1 Production method: first , (1) to (6) are mixed, heated and melted, and kept at 75 ° C. On the other hand, the aqueous phases (7) to (10) are mixed and dissolved by heating to 75 ° C., and the oil phase is added thereto with stirring to emulsify. After cooling, add (11) and (12) at 40 ° C and mix.

Example 3 Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) Octyldodeca Knol 10.0 (6) polyoxyethylene (25EO) cetyl alcohol ether 3.0 (7) glyceryl monostearate 2.0 (8) 1,3-butylene glycol 3.0 (9) diethylene glycol monoethyl ether 3 5.0 (10) Purified water 54.9 (11) Fujudaiju leaf, 50% by weight ethanol aqueous solution extract 3.0 (12) Fragrance 0.1 Production method: Mix the oil phase components of (1) to (7), Heat to 75 ° C. On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 7
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
Add (11) and (12) at 0 ° C.

Example 4 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Self-emulsifying glyceryl monostearate 2.0 (4) Propylene glycol 10.0 (5) Glycerin 3.0 (6) Potassium hydroxide 0.3 (7) Purified water 67.6 (8) Natsubodaiju flower, 1,3-butylene glycol extract 1.5 (9) Fragrance 0 1 (10) Titanium dioxide 1.0 (11) Bengala 0.1 (12) Yellow iron oxide 0.4 Production method: (10) to (12) are kneaded with (4), and this is kneaded with (5) to (5). Add to the aqueous phase of 7), mix and heat to 70 ° C. On the other hand, (1)-
The oil phase component of (3) is mixed and heated to 70 ° C., and this is added to the aqueous phase with stirring to emulsify. After emulsification, cool and add (8) and (9) at 40 ° C.

Example 5 Emulsion Foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Glyceryl monostearyl ether 3.5 (8) Sodium carboxymethyl cellulose 0.2 (9) Bentonite 0.5 (10) Isoprene glycol 4 7.0 (11) Triethanolamine 1.1 (12) Purified water 52.0 (13) Extract of a flower of a syrup, 50% by weight aqueous ethanol 2.5 (14) Fragrance 0.1 (15) Titanium oxide 0 (16) Talc 4.0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Production method: After mixing pigments of (15) to (19), pulverizer And pulverize. (12) is heated to 70 ° C., (9) is added to swell well, to which is added (8) previously dispersed in (10), and (11) is further added and dissolved. The oil phases (1) to (7) are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, the mixture is heated to 75 ° C. through a colloid mill, and the oil phase is added with stirring to emulsify.
(13) and (14) are added at ° C.

Example 6 Cream Foundation (1) Stearic acid 5.0 (% by weight) (2) Lipophilic glyceryl monostearate 2.5 (3) Propylene glycol monolaurate 3.0 (4) Cetostearyl alcohol 1.0 (5) Liquid paraffin 7.0 (6) Isopropyl myristate 8.0 (7) Diglycerin 3.0 (8) Triethylene glycol 2.0 (9) Triethanolamine 1.2 ( 10) Purified water 44.2 (11) Linden bark 50% by weight aqueous 1,3-butylene glycol extract 2.0 (12) Fragrance 0.1 (13) Titanium oxide 8.0 (14) Kaolin 5.0 (15) Talc 2.0 (16) Bentonite 1.0 (17) Bengala 2.6 (18) Yellow iron oxide 2.1 (19) Black iron oxide 0.3 Production method: pigments of (13) to (19) And then pulverized by a pulverizer. Mix and dissolve (7) to (10) and heat. (1) ~
The oil phase of (6) is mixed and dissolved by heating to 80 ° C. The pigment is added to the aqueous phase with stirring, the mixture is heated to 75 ° C. through a colloid mill, the oil phase is added with stirring to emulsify, and after cooling, (11) and (12) are added at 40 ° C.

[Example 7] Emulsion type eye color (1) Stearic acid 8.0 (wt%) (2) White petrolatum 15.0 (3) Isopropyl palmitate 5.0 (4) Lanolin 5.0 (5 ) 1,3-butylene glycol 5.0 (6) hexylene glycol 5.0 (7) triethanolamine 2.0 (8) purified water 50.83 (9) Fubodaiju flower, 50% by weight aqueous ethanol extract 1.25 (10) Lavender ethanol extract 1.25 (11) Fragrance 0.15 (12) Red No. 221 0.02 (13) Ultramarine blue 1.50 Production method: Mix aqueous phases (5) to (8) Then, the mixture is dissolved and heated, and (12) and (13) previously mixed and pulverized are added thereto, dispersed and heated to 75 ° C. (1) to (4), which were previously mixed and heated to make it uniform, were added with stirring to emulsify, and after cooling, (9) to (11) were added and mixed.

Example 8 Emulsion type teak color (1) Beeswax 3.0 (% by weight) (2) Stearic acid 2.0 (3) Cetanol 3.0 (4) Lanolin 3.0 (5) Liquid paraffin 15.0 (6) Isopropyl myristate 7.0 (7) Polyoxyethylene (20EO) sorbitan monostearate 4.2 (8) Sorbitan monostearate 1.8 (9) Glyceryl monostearate 2. 0 (10) Glyceryl monopalmityl ether 2.0 (11) Propylene glycol 5.0 (12) Triethanolamine 0.6 (13) Purified water 46.95 (14) Fujudaiju fruit, 50% by weight aqueous ethanol extraction Product 2.0 (15) Fragrance 0.15 (16) Red No. 202 0.05 (17) Yellow iron oxide 2.25 Production method: Mix, dissolve and heat the aqueous phases of (11) to (13), Mix and crush in advance (16), adding (17), dispersed and heated to 75 ° C.. (1) to (10), which were previously mixed and heated to make it uniform, were added with stirring to emulsify, and after cooling, (14) and (15) were added and mixed.

Example 9 Emulsion Type Eyeliner (1) Stearic acid 3.5 (% by weight) (2) Beeswax 2.0 (3) Carnauba wax 0.5 (4) Microcrystalline wax 5.0 (5) 1,3-butylene glycol 7.0 (6) Ethylene glycol monobutyl ether 2.5 (7) Triethanolamine 1.5 (8) Purified water 45.9 (9) Natsubodaiju leaf, 50% by weight 1,3- Butylene glycol aqueous solution extract 2.0 (10) Fragrance 0.1 (11) 3.0% by weight bentonite extract 20.0 (12) Titanium oxide 8.0 (13) Carbon black 2.0 Production method: (1) The oil phase components of (4) to (4) are mixed and heated to dissolve. The aqueous phases (5) to (8) are mixed, heated, and added with stirring to emulsify. Next, (11) to (13)
, And dispersed by passing through a colloid mill, followed by cooling.
Add (9) and (10) at 0 ° C.

Example 10 Aqueous Suspension Mascara (1) 50% by weight of vinyl acetate emulsion 37.0 (% by weight) (2) Sodium carboxymethylcellulose 1.0 (3) 1,3-butylene glycol 3.5 (4) Ethylene glycol monomethyl ether 3.5 (5) Aesculus sylvestris flower, 50% by weight aqueous 1,3-butylene glycol extract 1.0 (6) Titanium oxide 8.0 (7) Carbon black 1.6 (8 ) Bengala 0.4 (9) Purified water 44.0 Production method; (2) to (5) were added to (9) and dissolved,
(6) to (8) are added and dispersed through a colloid mill. Add (1) to this and disperse uniformly.

Example 11 Cleansing Gel (1) Glycerin 15.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Silicic anhydride 7.0 (4) Polyoxyethylene (20EO) ) Lauryl ether 5.0 (5) Polyoxyethylene (50EO) hydrogenated castor oil 2.5 (6) Diethylene glycol monoethyl ether 5.0 (7) Carboxyvinyl polymer 0.5 (8) Potassium hydroxide 0.45 ( 9) Fuyudaidai flower, 50% by weight 1,3-butylene glycol aqueous solution extract 2.0 (10) Fragrance 0.1 (11) Purified water 52.45 Production method; (3), (7) to (11) After adding and making uniform, (4) to (6) are dissolved and added to (1) and (2), and the mixture is heated to 70 ° C. and uniformly dissolved. Then cool and at 40 ° C (9),
(10) is added, and finally (8) is added for neutralization.

Example 12 Hair rinse (1) Cetanol 3.0 (% by weight) (2) Stearyl trimethylammonium chloride 0.7 (3) Silicone oil 3.0 (4) Polyoxyethylene (10EO) oleyl ether 1 0.0 (5) Glycerin 5.0 (6) Aesculus edulis flower / water extract 1.5 (7) Green No. 3 1% by weight aqueous solution 0.2 (8) Fragrance 0.1 (9) Purified water 85.5 Production method: (5) and (7) are added to (9) and heated to 70 ° C. On the other hand, (1) to (4) are mixed and dissolved, and heated to 70 ° C. This oil phase was gradually added to the previously prepared aqueous phase while stirring, and pre-emulsified, homogenized by adding a homomixer, and then cooled,
At 40 ° C., (6) and (8) are added.

Example 13 Hair Treatment (1) Polyoxyethylene (30EO) behenyl ether 4.0 (% by weight) (2) Self-emulsifying glyceryl monostearate 6.0 (3) Isopropyl myristate 0 (4) hexyldecanol 5.0 (5) squalane 3.0 (6) purified lanolin 3.0 (7) stearic acid 5.0 (8) lauryl dimethylaminoacetate betaine 5.0 (9) glycerin 10.0 ( 10) Purified water 52.8 (11) Fragrance 0.2 (12) Nutsoudaiju flower, 75% by weight 1,3-butylene glycol aqueous solution extract 1.0 Production method: oil phase components of (1) to (7) Mix and heat to 80 ° C. On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 8
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
At 0 ° C. add (11) and (12).

Example 14 Face Wash (1) Liquid paraffin 25.0 (% by weight) (2) Cetanol 2.0 (3) Lanolin 2.0 (4) Glyceryl monostearate 5.0 (5) Poly Oxyethylene stearyl ether 5.0 (6) Polyoxyethylene (20EO) sorbitan monostearate 1.0 (7) 1,3-butylene glycol 10.0 (8) Purified water 48.4 (9) Fragrance 0.1 (10) Hydrangea flower ・ 50% by weight 1,3-butylene glycol aqueous solution extract 1.5 Production method: The oil phase of (1) to (6) and the aqueous phase of (7) and (8) are each brought to 65 ° C. After mixing and heating, the aqueous phase is added to the oil phase to emulsify. After cooling, (9) and (10) are added and mixed at 40 ° C.

Example 15 Body Shampoo (1) Sodium lauryl ether sulfate 20.0 (wt%) (2) Sodium myristyl ether sulfate 10.0 (3) Capric acid diethanolamide 3.0 (4) Polyoxypropylene (10PO) Polyoxyethylene (20EO) cetyl ether 3.5 (5) Sodium chloride 2.5 (6) Glycerin 10.0 (7) Aesculus sylvestris flower, 50% by weight aqueous 1,3-butylene glycol extract 0. 5 (8) Fragrance 0.3 (9) Purified water 50.2 Production method: Each component of (1) to (8) is sequentially added to (9) and uniformly mixed.

Next, the above Examples 1 to 15 were evaluated for antibacterial activity, skin irritation and discomfort during use. At the same time, the comparative examples shown in Table 1 were similarly evaluated for antibacterial activity.

[0040]

[Table 1]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli and Staphylococc
us aureus ) and Pseudomonas aeruginosa
Using Candida albicans and black mold ( Aspergillus niger ) as fungi, inoculating 10 ⁶ bacteria and 10 ⁵ fungi per gram of the sample, culturing at 37 ° C. and 25 ° C., respectively, for 2 weeks The number of viable bacteria was measured later. In addition, the antibacterial activity was judged to be acceptable when the bacteria died after 2 weeks, and when the viable count of the fungi became 1/1000 or less, the bacteria passed. The results of the antibacterial test
In Tables 2 and 3, those that passed were indicated by “「 ”, and those that failed were indicated by“ x ”.

[0042]

[Table 2]

[0043]

[Table 3]

As apparent from Table 2, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was recognized. On the other hand, as shown in Table 3, in Comparative Examples 2, 5, 7, 9, 11, 13 and 15 containing only the extract of the genus Lindus, the antibacterial activity against most test bacteria was observed. Not allowed. Comparative Examples 1, 3, 4, and 4 containing a considerable amount of polyhydric alcohol and alkyl ether of polyhydric alcohol
6, 8, 10, 12, and 14 also did not meet the acceptance criteria for most of the test bacteria.

(2) Evaluation of skin irritation For each of the examples, a 30-year-old male panelist was subjected to a 48-hour obstruction sticking test, and evaluated according to the criteria shown in Table 4. The value was determined. In Examples 11 to 15, a 1.0% by weight aqueous solution was used for the test.

[0046]

[Table 4]

(3) Evaluation of discomfort during use Twenty female panelists were used as a group, each group was allowed to use each of the examples, and the stinging pain and tingling felt from 30 seconds to 1 minute after application. Discomfort such as sensation and tingling were evaluated. The evaluation result was "very strong; 5 points",
"Somewhat strong; 4 points", "Some; 3 points", "Slightly; 2 points", "Slightly; 1 point", "Not felt; 0 points" Shown.
Also at this time, for Examples 11 to 15,
A 1.0% by weight aqueous solution was used for the test. Table 5 shows the above results.
Are shown together.

[0048]

[Table 5]

In Table 5, no skin irritation was observed in any of the examples of the present invention.
Discomfort during use is also subtle.

[0050]

As described above in detail, according to the present invention, the antibacterial action is synergistically enhanced, and not only skin irritation but also discomfort such as stinging, tingling and tingling when used. It was possible to obtain an antibacterial cosmetic which was hardly felt.

Claims (7)

[Claims] 1. An antibacterial anti-irritant cosmetic, characterized in that one or more selected from polyhydric alcohols and alkyl ethers of polyhydric alcohols are used in combination with extracts of plants of the genus Linus. 2. One or more polyhydric alcohols are:
The antibacterial hypoallergenic cosmetic according to claim 1, wherein the cosmetic is selected from those having 4 or less hydroxyl groups in a molecule. 3. An alkyl ether of a polyhydric alcohol.
The species or two or more species are selected from mono and dialkyl ethers of ethylene glycol, diethylene glycol and triethylene glycol, mono and dialkyl ethers of propylene glycol and dipropylene glycol, and mono, di and trialkyl ethers of glycerin. The antibacterial and hypoallergenic cosmetic according to claim 1 or 2. 4. The antibacterial and hypoallergenic cosmetic according to claim 1, wherein the extract of a plant of the genus Lindus is a polar solvent extract. 5. An extract of a plant of the genus Lindus comprising 50% by weight of 1,
The antibacterial and hypoallergenic cosmetic according to any one of claims 1 to 4, which is an aqueous solution of 3-butylene glycol. 6. The plant of the genus Lindensis is characterized by the following:
ia cordata Mill., Tilia ulmifolia Scop., Tilia par
vifolia Ehrh.), Natsubodaiju ( Tilia platyphyllos)
The antibacterial anti-irritant cosmetic according to any one of claims 1 to 5, wherein the cosmetic is one or two or more selected from Scop., Tilia grandifolia Ehrh.) And European linden ( Tilia europaea L.). 7. The antibacterial and hypoallergenic cosmetic according to claim 1, wherein the extract of a genus Lindenium is an extract of a flower of a linden plant.