JPH10203954A - Antimicrobial low-irritating cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic having excellent antimicrobial action, not exhibiting primary irritation and sensitization, and also not giving stabbing pain or unpleasant feeling such as irritating sensation or pricking sensation. SOLUTION: This antimicrobial and low-irritating cosmetic is obtained by combinedly using extracts of one or two or more kinds of plants selected from plants of the genus Tilia, especially Tilia cordata Mill., Tiliaulmifolia Scop. or Tilia parvifolia Ehrh., Tilia platyphyllos Scop. or Tilia grandifolia Ehrh. and Tilia europaeaL., with one or two or more kinds of substances selected from a group comprising para-oxybenzoic acid esters, phenoxyethanol, photosensitive dye No.101 (platonin), photosensitive dye No.201 (pionin), photosensitive dye No.401 (luminex), hinokitiol, N-long chain aryl basic amino acid derivative and its acid addition salt and zinc oxide.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and fungi, is stable and has low skin irritation. More specifically, an extract of a plant of the genus Linus, paraoxybenzoic acid esters, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer No. 401 (luminex), hinokitiol, N-long chain The present invention relates to a highly antibacterial and hypoallergenic cosmetic comprising one or more selected from the group consisting of an acyl basic amino acid derivative, an acid addition salt thereof, and zinc oxide.

[0002]

2. Description of the Related Art Conventionally, cosmetics containing water, such as lotions, emulsions, creams, etc., have various antibacterial and antibacterial properties in order to prevent deterioration due to the incorporation of microorganisms such as bacteria and fungi during production and use. Fungicides have been used. Examples of such preservatives include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; Quaternary ammoniums such as benzalkonium, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

[0003] However, many of the above-mentioned antibacterial and fungicides have been reported as having primary irritation, sensitization or photosensitization to the skin. In many cases, an amount showing an effective antibacterial activity cannot be blended. Further, even when the cosmetic does not show a stimulating or sensitizing reaction such as redness, rash, or edema to the skin, it may cause discomfort such as stinging, burning, or tingling when using the cosmetic. Are known. In addition, due to the interaction with the base of the cosmetic or other compounding components, there may be cases where sufficient antibacterial activity is not exhibited.

For example, isopropylmethylphenol,
When an oil-soluble antibacterial and fungicide such as paraoxybenzoate and sorbic acid is added to a cosmetic containing a polymer thickener or powder, the antibacterial activity is reduced by adsorption or the like. Further, in cosmetics containing a surfactant, the antibacterial activity is also reduced due to incorporation into surfactant micelles.
On the other hand, if a large amount is added in anticipation of a sufficient antibacterial activity, problems such as crystal precipitation at low temperatures and the like arise in product stability.

Water-soluble preservatives such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. As it becomes stronger, its solubility in water decreases,
Crystal precipitation may occur.

[0006] Further, quaternary ammoniums and amphoteric surfactants are irritating to the skin and mucous membranes of the eyes, and are liable to foam, and the antibacterial activity decreases on the acidic side.
There are practical problems such as interaction with anionic substances.

[0007]

Accordingly, in the present invention, an effective antibacterial action is exhibited without deteriorating the antibacterial activity by a cosmetic base or other compounding components, and a preservative or fungicide is added as much as possible. To obtain cosmetics that not only do not show primary irritation and sensitization to the skin but also do not cause discomfort such as stabbing pain, tingling or tingling when using cosmetics by reducing the amount Aimed at.

[0008]

In order to solve the above-mentioned problems, an antiseptic / antifungal system having high stability and low allergic, irritant and toxic properties was studied. Consists of esters, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer No. 401 (luminex), hinokitiol, N-long-chain acyl basic amino acid derivatives and acid addition salts thereof, and zinc oxide The present invention has been found to not only synergistically improve antibacterial activity but also significantly reduce skin irritation and discomfort by including one or more selected from the group in combination. Was completed.

[0009]

Tilia plants used in DETAILED DESCRIPTION OF THE INVENTION The present invention is a kind of Tiliaceae plants (Tiliaceae), American linden (Tilia americana L.), Tilia cordata (Tilia
cordata Mill., Tilia ulmifolia Scop., Tilia parvi
folia Ehrh.) European linden ( Tilia europaea )
L.), linden ( Tilia japonica (Miq.) Simonk.), Herring tree ( Tiliakiusiana Makino et Shiras.), Squid ( Tilia maximowicziana Shiras.), Bodaiju ( T
ilia miqueliana Maxim.), Natsubodaiju ( Tilia plat
yphyllos Scop., Tilia grandifolia Ehrh.) and the like.

[0010] Among the above-mentioned plants of the genus Linus, from the point of antibacterial activity, it is said that T. cordata ( Tiliacordata Mill., Til .
ia ulmifolia Scop., Tilia parvifolia Ehrh.), Natsudaidai ( Tilia platyphyllos Scop., Tilia grandif)
olia Ehrh.), European linden ( Tilia europaea L.)
It is preferable to use one or more plant extracts selected from

The linden genus plants such as Bodaiju are widely used as a folk medicine in Europe. The essential oil obtained from the dried inflorescence is used as a sweat, antispasmodic or bathing agent. It has been used for burns and wound healing.

The extraction site for obtaining the extract of the linden plant is not particularly limited, but the bark and its mucus, fruit,
Examples include seeds, flowers, branches and leaves, and among them, extracts of linden flowers are most preferred from the viewpoint of antibacterial action.

When an extract is obtained from these plants, the plants can be extracted in a raw or dried state. However, from the viewpoint of odor and storage stability, it is necessary to use the dried product as it is or after pulverizing it. preferable.

Solvents for obtaining these plant extracts include water, ethanol, methanol, isopropanol,
Alcohols such as isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene Glycol monoethyl ether, triethylene glycol,
Polyhydric alcohols such as 1,3-butylene glycol and hexylene glycol or derivatives thereof, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; esters such as ethyl acetate and isopropyl acetate; ethyl ether One or a mixture of two or more polar solvents such as ethers such as isopropyl ether, n-butyl ether and the like can be preferably used.
There is no particular limitation. Alternatively, aliphatic hydrocarbons such as petroleum ether, n-hexane, n-pentane, n-butane, n-octane, cyclohexane, carbon tetrachloride, chloroform,
One or a mixture of two or more of nonpolar solvents such as dichloromethane, trichloroethylene, benzene, and toluene can also be suitably used.

The solvent from which the extract of the genus Lindenium is obtained is not particularly limited as long as it is the above solvent, but a polar solvent is preferable from the viewpoint of antibacterial action.
One or more mixed solvents of 1,3-butylene glycol and water are preferable, and among them, 50% by weight as an extraction solvent
A 1,3-butylene glycol aqueous solution is most preferred.

Further, as an extraction method, a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, an extract by pressing from a raw plant of the genus Lindwood. And the like. Extraction is performed using these methods alone or in combination of two or more.

The ratio of the plant to the solvent at the time of extraction is not particularly limited.
It is preferably 0 times by weight, especially 5 to 100 times by weight in terms of extraction operation and efficiency. The extraction temperature is conveniently in the range from room temperature to the boiling point of the solvent under normal pressure, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.

[0018] The extract of the genus Lindus plant thus obtained can be used as it is,
In addition, it can be blended after deodorizing, purifying and the like are added within a range that does not lose the fungicidal and fungicidal action, and can also be used as a fraction using column chromatography or the like. Further, these extracts, deodorized, purified, and fractionated products can be dried by removing the solvent therefrom, and further provided in the form of a solution solubilized in a solvent such as alcohol or in the form of an emulsion. can do.

In the present invention, as substances to be used in combination with extracts of plants of the genus Linus, paraoxybenzoates, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer No. 401 (luminex) , Hinokitiol, N-long-chain acyl basic amino acid derivatives and acid addition salts thereof, and zinc oxide. One or more of these are selected and blended.

The paraoxybenzoic acid esters include:
Examples thereof include methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, isopropyl paraoxybenzoate, and isobutyl paraoxybenzoate. In the present invention,
A synergistic improvement in antibacterial activity is observed when used in combination with an extract of a genus Lindenium, so that the amount of these components is about 0.01 to 0.2% by weight.

With respect to phenoxyethanol, in the present invention, a sufficient antibacterial activity can be obtained by adding about 0.05 to 0.3% by weight. In addition, Photosensitive Element No. 101 (platonin), Photosensitive Element No. 201 (Pionin) and Photosensitive Element No. 401 (Luminex) are each 0.00
About 01 to 0.002% by weight is sufficient. For hinokitiol, a blending ratio of 0.0001 to 0.1% by weight is appropriate.

The N-long-chain acyl basic amino acid derivatives include the following general formulas (1), (2) and (3)
Are preferred, and one or two or more of these and acid addition salts thereof are selected and used.

[0023]

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[0024]

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[0025]

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(However, in the general formulas (1) to (3),
RCO is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, X is _{-NH 2, -OCH 3, -OC 2} H 5, -OC 3 H 7, -O
Represents C ₄ H ₉ or —OCH ₂ C ₆ H ₅ , and in the general formula (2), n
Represents 3 or 4)

For example, N-caproyl-L-arginine methyl ester hydrochloride, N-lauroyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate, N-palmitoyl
-L-arginine ethyl ester hydrochloride, N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate,
N-caproyl-L-lysine methyl ester hydrochloride, N-lauroyl-L-lysine ethyl ester-DL-pyrrolidone carboxylate, N-myristoyl-L-lysine propyl ester hydrochloride, N-cocoyl-L-lysine methyl ester -DL-pyrrolidone carboxylate, N-stearoyl-L-histidine methyl ester hydrochloride, N-oleoyl-L-histidine ethyl ester-DL-pyrrolidone carboxylate, and the like. A suitable amount is about 0.001 to 0.5% by weight.

The cosmetic according to the present invention can be in any form such as cream, ointment, lotion, emulsion, solid, powder, etc., and basic cosmetics such as lotion, emulsion, serum, moisturizing cream, etc. Sun care products such as sunscreen creams, sunscreen lotions, suntan oils, carmine lotions, foundations, makeup cosmetics such as eyeliner, mascara, eye color, cheek color, lipstick, face wash, body shampoo, hair shampoo, etc. Hair cosmetics such as cleaning agents, rinses, treatments, hair creams, hair oils, hair styling agents, perfumes,
It can be provided in the form of a deodorant and antiperspirant.

At this time, various components generally used in cosmetics such as avocado oil, palm oil, peanut oil, rice bran oil, jojoba oil, orange roughy oil, macadamia nut, as long as the effects of the present invention are not impaired. Oil, squalane, evening primrose oil, sesame oil, sunflower oil, safflower oil, carola oil, carnauba wax, paraffin wax, lanolin, diisostearyl malate, isostearyl alcohol, oils such as liquid paraffin, glycerin, diglycerin , Polyglycerin, sorbitol, polyethylene glycol, 1,3-butylene glycol, collagen, hyaluronic acid and other humectants, vitamin A
Oil, retinol, vitamin A such as retinol acetate, riboflavin, vitamin B ₂ such as riboflavin butyrate, vitamin B ₆ such as pyridoxine hydrochloride, L- ascorbic acid, L-
Vitamin Cs such as magnesium ascorbyl phosphate, sodium L-ascorbate, calcium pantothenate, D
-Pantothenic acids such as pantothenyl alcohol, pantothenyl ethyl ether, and acetyl pantothenyl ethyl ether; vitamin D such as ergocalciferol and cholecalciferol; nicotinic acid, nicotinamide;
Nicotinic acids such as benzyl nicotinate, vitamin Es such as α-tocopherol and tocopherol acetate, vitamin P,
Vitamins such as biotin, benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, para-aminobenzoate Acid, ethyl para-aminobenzoate,
Para-aminobenzoic acid derivatives such as octyl para-dimethylaminobenzoate; 2-ethylhexyl paramethoxycinnamate;
Methoxycinnamic acid derivatives such as glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, salicylic acid derivatives such as octyl salicylate and myristyl salicylate, urocanic acid, 4-tert-butyl-4′-methoxydibenzoylmethane, 2- (2 UV absorbers such as'-hydroxy-5'-methylphenyl) benzotriazole, natural plant polysaccharides such as guar gum, locust bean gum, carrageenan, quince seed, pectin, mannan, xanthan gum, dextran, curdlan, hyaluronic acid, etc. Microbial natural polysaccharides, animal macromolecules such as gelatin, casein, albumin, collagen, methylcellulose, ethylcellulose,
Cellulose semi-synthetic polymers such as hydroxyethylcellulose, hydroxypropylcellulose and carboxymethylcellulose; starch-based semi-synthetic polymers such as soluble starch, carboxymethyl starch and methyl starch; and alginic acid-based semi-synthetic polymers such as alginate propylene glycol ester and alginate. Molecules, synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, and polyethylene oxide; water-soluble polymers such as bentonite, laponite, and colloidal alumina; dibutylhydroxytoluene and butylhydroxyl Antioxidants such as anisole and gallic acid esters, higher fatty acid soaps, alkyl sulfates, polyoxyethylene alkyl ether sulfates, Anionic surfactants such as rumethyltaurine salt, alkyl ether phosphate salt, acylamino acid salt, etc., cationic surfactants such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, benzalkonium chloride, betaine, alkyldimethylaminoacetate, alkyl Ampholytic surfactants such as amidodimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene glycol , Polyoxyethylene polyoxypropylene alkyl ether, polyoxyalkylene fatty acid glycerin ester, polyoxyalkylene sorbitan ester, sorbit oligomer Nonionic surfactants such as tetraester, sorbitol oligomeric hexaester, polyethylene glycol ester, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, alkylolamide, fatty acid amide, ethylenediaminetetraacetic acid sodium salt, sodium polyphosphate , Citric acid, sodium metaphosphate, succinic acid, gluconic acid and other sequestering agents, placenta extract, sorrel extract, glutathione, kojic acid and its derivatives, hydroquinones such as hydroquinone glycosides and whitening of their derivatives Glycyrrhizic acid,
Anti-inflammatory agents such as glycyrrhetinic acid, allantoin, azulene, hydrocortisone, ε-aminocaproic acid, astringents such as allantoin hydroxyaluminum, aluminum chloride, tannic acid, citric acid, lactic acid, menthol,
Cooling agents such as camphor; antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate; sebum suppressants such as estradiol, estrone and ethinyl estradiol; exfoliation of salicylic acid and resorcinol;
A dissolving agent, α-hydroxy acids, and the like can be blended.

[0030]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

[Example 1] Lotion (1) Ethanol 5.0 (% by weight) (2) 1,3-butylene glycol 6.0 (3) Glycerin 2.0 (4) Polyoxyethylene (50EO) curing Castor oil 0.6 (5) Antelope flower, 50% by weight 1,3-butylene glycol aqueous extract 0.5 (6) Phenoxyethanol 0.05 (7) Perfume 0.05 (8) Purified water 85.8 : Each component of (1) to (7) is sequentially added to (8) and uniformly mixed.

Example 2 Emulsion (1) Squalane 4.0 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 2.0 (3) Cetyl 2-ethylhexanoate 3.0 (4) Cetanol 0.6 (5) Stearyl alcohol 0.4 (6) Sorbitan monostearate 1.2 (7) 1,3-butylene glycol 6.0 (8) Glycerin 4.0 (9) Polyoxyethylene (20EO) Sorbitan 0.8 monostearic acid ester (10) Purified water 73.899 (11) Photosensitizer No. 101 0.001 (12) Botanical vegetative flower, 50% by weight aqueous 1,3-butylene glycol extract 4.0 (13) ) Fragrance 0.1 Production method: First, the oil phases (1) to (6) are mixed, heated and melted, and kept at 75 ° C. On the other hand, the aqueous phases (7) to (10) are mixed and dissolved by heating to 75 ° C., and the oil phase is added thereto with stirring to emulsify. After cooling, (11) to (13) are sequentially added and mixed at 40 ° C.

Example 3 Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) Octyldodeca Knol 10.0 (6) Polyoxyethylene (25EO) cetyl alcohol ether 3.0 (7) Glyceryl monostearate 2.0 (8) 1,3-butylene glycol 6.0 (9) Purified water 56.36 (10) Ethanol 1.0 (11) Fujudaiju leaf / 50% by weight aqueous ethanol extract 0.5 (12) Propyl parahydroxybenzoate 0.04 (13) Fragrance 0.1 Production method: (1) to (7) The oil phase components are mixed and heated to 75 ° C. On the other hand, the aqueous phase components (8) and (9) were mixed and heated to 7
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
At 0 ° C., the components (11) to (13) are dissolved in (10) and added.

[Example 4] Oil-based cleansing cream (1) Ceresin 8.0 (% by weight) (2) Microcrystalline wax 5.0 (3) White petrolatum 35.0 (4) Squalane 48.99 (5) Stearin Magnesium citrate 2.0 (6) Butyl paraoxybenzoate 0.01 (7) Nutsoudaiju flower, 1,3-butylene glycol extract 1.0 Production method: Mix and heat components (1) to (6) Gelled,
After cooling, the component (7) is added at 40 ° C.

[Example 5] Emulsion foundation (1) Stearic acid 2.4 (wt%) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Sodium carboxymethylcellulose 0.2 (8) Bentonite 0.5 (9) Propylene glycol 4.0 (10) Triethanolamine 1. 1 (11) Purified water 56.48 (12) Nutsoudaiju flower, 50% by weight aqueous ethanol extract 1.5 (13) Hinokitiol 0.02 (14) Fragrance 0.1 (15) Titanium oxide 8.0 (16 ) Talc 4.0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Production method: After mixing the pigments of (15) to (19), pulverize through a pulverizer. . (11) is heated to 70 ° C., (8) is added to swell well, to which is added (7) previously dispersed in (9), (10) is further added and dissolved, and the aqueous phase is dissolved. I do. (1)-(6)
Are mixed and heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring and passed through a colloid mill for 75 minutes.
C., and the oil phase was added with stirring to emulsify. After cooling, the components (12) to (14) were added at 40.degree.

[Example 6] Powder foundation (1) Talc 36.0 (% by weight) (2) Mica 20.0 (3) Nylon powder 15.0 (4) Titanium oxide 10.0 (5) Zinc oxide 2 5.5 (6) Bengala 3.0 (7) Yellow iron oxide 2.5 (8) Black iron oxide 0.5 (9) Squalane 5.0 (10) Octyldodecyl myristate 2.5 (11) Macadamian nut Oil 2.5 (12) Flavor 0.15 (13) Linden bark / 50% by weight 1,3-butylene glycol aqueous solution extract 0.35 Production method: (1) to (8) are mixed and pulverized through a pulverizer. .
This is transferred to a high-speed blender, and (9) to (13) are added and mixed to make it uniform. Furthermore, after processing with a crusher and passing through a sieve to adjust the particle size, the mixture is filled into a gold plate and compression molded.

Example 7 Aqueous Suspension Mascara (1) 50% by weight of vinyl acetate emulsion 30.0 (% by weight) (2) Sodium carboxymethylcellulose 1.0 (3) 1,3-butylene glycol 3.0 (4) Fubodaiju flower / 50 wt% ethanol aqueous solution extract 1.0 (5) Methyl parahydroxybenzoate 0.1 (6) Titanium oxide 8.0 (7) Carbon black 1.6 (8) Bengala 0.4 (9) Purified water 54.9 Production method; (2) to (5) were added to (9) to dissolve
(6) to (8) are added and dispersed through a colloid mill. Add (1) to this and disperse uniformly.

Example 8 Shampoo (1) Sodium alkyl ether sulfate 18.0 (% by weight) (2) Palm oil fatty acid diethanolamide 2.0 (3) Bodaiju fruit / 50% by weight aqueous ethanol extract 2.5 (4) N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate 0.05 (5) Yellow 4 1% by weight aqueous solution 0.1 (6) Fragrance 0.1 (7) Purified water 77.25 Production method: (1) to (6) are sequentially added to (7) and uniformly mixed and dissolved.

Example 9 Hair rinse (1) Cetanol 2.0 (% by weight) (2) Stearyltrimethylammonium chloride 2.0 (3) Silicone oil 3.0 (4) Polyoxyethylene oleyl ether (10EO) 1 0.0 (5) Glycerin 3.0 (6) N-myristoyl-L-lysine ethyl ester hydrochloride 0.07 (7) Nutsoudaiju leaves, 50% by weight aqueous 1,3-butylene glycol extract 2.0 (8 ) Fragrance 0.1 (9) Purified water 86.83 Production method; (5) and (6) are added to (9) and heated to 70 ° C. On the other hand, (1) to (4) are mixed and dissolved, and heated to 70 ° C. This oil phase was gradually added to the previously prepared aqueous phase while stirring, and pre-emulsified, homogenized by adding a homomixer, and then cooled,
At 40 ° C., (7) and (8) are added.

Example 10 Hair Cream (1) Polyoxyethylene (10EO) behenyl ether 5.0 (% by weight) (2) Hexyldecanol 5.0 (3) Liquid paraffin 35.0 (4) Purified lanolin 2 0.0 (5) Cetanol 2.0 (6) Glycerin 5.0 (7) Botanical linden flower, 50% by weight aqueous 1,3-butylene glycol extract 0.2 (8) Purified water 45.699 (9) Fragrance 0.1 (10) Photosensitive element 401 No. 0.001 Production method: The oil phase components (1) to (5) are mixed and heated to 75 ° C. On the other hand, the aqueous phase components (6) to (8)
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
At 0 ° C., add (9) and (10).

Example 11 Hair Treatment (1) Polyoxyethylene (30EO) behenyl ether 4.0 (% by weight) (2) Self-emulsifying glyceryl monostearate 6.0 (3) Isopropyl myristate 0 (4) hexyldecanol 5.0 (5) squalane 3.0 (6) purified lanolin 3.0 (7) stearic acid 5.0 (8) lauryl dimethylaminoacetate betaine 5.0 (9) glycerin 5.0 ( 10) Purified water 57.72 (11) Fragrance 0.2 (12) Fujudaiju flower, 50% by weight 1,3-butylene glycol aqueous solution extract 1.0 (13) Phenoxyethanol 0.08 Production method: (1)-( The oil phase component of 7) is mixed and heated to 80 ° C. On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 8
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
At 0 ° C. add (11)-(13).

Example 12 Face Wash (1) Liquid Paraffin 25.0 (% by weight) (2) Cetanol 2.0 (3) Lanolin 2.0 (4) Glyceryl Monostearate 5.0 (5) Poly Oxyethylene stearyl ether 5.0 (6) Polyoxyethylene (20EO) sorbitan monostearate 1.0 (7) Glycerin 2.0 (8) Purified water 56.898 (9) Fragrance 0.1 (10) Fujudaiju Flower 50% by weight 1,3-butylene glycol aqueous solution extract 1.0 (11) Photosensitizer 201 0.002 Production method: oil phase of (1) to (6) and aqueous phase of (7), (8) Are mixed and dissolved at 65 ° C., and then the aqueous phase is added to the oil phase to emulsify. After cooling, (9) to (11) are added and mixed at 40 ° C.

Example 13 Body Shampoo (1) Sodium lauryl ether sulfate 20.0 (% by weight) (2) Sodium myristyl ether sulfate 10.0 (3) Capric acid diethanolamide 3.0 (4) Polyoxypropylene (10PO) Polyoxyethylene (20EO) cetyl ether 3.5 (5) Sodium chloride 2.5 (6) Nutsoudaiju flower, 75% by weight 1,3-butylene glycol aqueous solution extract 0.5 (7) Fragrance 0. 3 (8) Photosensitizer 201 0.001 (9) Purified water 60.199 Manufacturing method: Each component of (1) to (8) is sequentially added to (9) and mixed uniformly.

Next, the above Examples 1 to 13 were evaluated for antibacterial activity, skin irritation and discomfort during use. At the same time, the comparative examples shown in Table 1 were similarly evaluated for antibacterial activity. However, in Example 4, since an antiseptic / antifungal agent was added for the purpose of preventing secondary contamination during use, evaluation of the antibacterial activity was not performed.

[0045]

[Table 1]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli , Staphylococc
us aureus ) and Pseudomonas aeruginosa
Using Candida albicans and black mold ( Aspergillus niger ) as fungi, inoculating 10 ⁶ bacteria and 10 ⁵ fungi per gram of the sample, culturing at 37 ° C. and 25 ° C., respectively, for 2 weeks The number of viable bacteria was measured later. In addition, the antibacterial activity was judged to be acceptable when the bacteria died after 2 weeks, and when the viable count of the fungi became 1/1000 or less, the bacteria passed. The results of the antibacterial test
In Tables 2 and 3, those that passed were indicated by “「 ”, and those that failed were indicated by“ x ”.

[0047]

[Table 2]

[0048]

[Table 3]

As is clear from Table 2, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. On the other hand, as shown in Table 3, in Comparative Examples 2, 7, 9, 11, and 13 containing only extracts of the genus Lindensis, no antibacterial activity was observed for most test bacteria. . In Comparative Examples 1, 3, 5, 6, 8, 10, and 12 containing a considerable amount of an antibacterial substance such as phenoxyethanol, some of the test bacteria did not satisfy the acceptance criteria.

(2) Evaluation of skin irritation For each example, 20 male panelists performed a 48-hour obstruction sticking test and evaluated according to the criteria shown in Table 4. The value was determined. Examples 8 to 9,
For 12 and 13, a 1.0% by weight aqueous solution was used for the test.

[0051]

[Table 4]

(3) Evaluation of discomfort during use A group of 20 female panelists was allowed to use each example in each group, and the stinging pain and tingling felt from 30 seconds to 1 minute after application. Discomfort such as sensation and tingling were evaluated. The evaluation result was "very strong; 5 points",
"Somewhat strong; 4 points", "Some; 3 points", "Slightly; 2 points", "Slightly; 1 point", "Not felt; 0 points" Shown.
Also at this time, about Examples 8-9, 12, and 13,
A 1.0% by weight aqueous solution was used for the test. Table 5 shows the above results.
Are shown together.

[0053]

[Table 5]

In Table 5, no skin irritation was observed in any of the examples of the present invention.
Discomfort during use is also subtle.

[0055]

As described above in detail, according to the present invention, the antibacterial action is synergistically enhanced, and not only skin irritation but also discomfort such as stinging, tingling and tingling when used. It was possible to obtain an antibacterial cosmetic which was hardly felt.

Claims (7)

[Claims] 1. An extract of a plant of the genus Linus, paraoxybenzoic acid esters, phenoxyethanol, and photosensitizer 1.
No. 01 (Platonin), Photosensitizer No. 201 (Pionin),
An antibacterial agent comprising one or more members selected from the group consisting of Photosensitizer 401 (Luminex), hinokitiol, N-long-chain acyl-basic amino acid derivatives and acid addition salts thereof, and zinc oxide Hypoallergenic cosmetics. 2. The antibacterial and hypoallergenic cosmetic according to claim 1, wherein the extract of a plant of the genus Lindus is a polar solvent extract. 3. An extract of a plant of the genus Lindus comprising 50% by weight of 1,
Characterized in that it is a 3-butylene glycol extract,
The antibacterial and hypoallergenic cosmetic according to claim 1 or 2. 4. An N-long-chain acyl-basic amino acid derivative and an acid addition salt thereof are represented by the general formulas (1), (2) and (3), and the acid addition salts thereof. The antibacterial anti-irritant cosmetic according to claim 1, wherein the cosmetic has a certain characteristic. Embedded image Embedded image Embedded image (However, in the general formulas (1) to (3), RCO is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, X is —NH ₂ ,
_{-OCH 3, -OC 2 H 5,} -OC 3 H 7, -OC 4 H 9 or -OC
It represents H ₂ C ₆ H ₅ , and in the general formula (2), n represents 3 or 4. ) 5. The amount of an extract of a plant belonging to the genus Lindus being 0.
001 to 10% by weight, paraoxybenzoates,
The amounts of phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer No. 401 (luminex), hinokitiol, N-long-chain acyl basic amino acid derivatives and their acid addition salts, and zinc oxide 0.01-0.2% by weight, 0.05-0.
3% by weight, 0.0001 to 0.002% by weight, 0.00
01-0.002% by weight, 0.0001-0.002% by weight, 0.0001-0.1% by weight, 0.001-0.
The antibacterial and hypoallergenic cosmetic according to any one of claims 1 to 4, wherein the cosmetic is 5% by weight and 0.1 to 30% by weight. 6. The plant of the genus Lindensis is characterized by the following:
ia cordata Mill., Tilia ulmifolia Scop., Tilia par
vifolia Ehrh.), Natsubodaiju ( Tilia platyphyllos)
The antibacterial anti-irritant cosmetic according to any one of claims 1 to 5, wherein the cosmetic is one or two or more selected from Scop., Tilia grandifolia Ehrh.) And European linden ( Tilia europaea L.). 7. The antibacterial and hypoallergenic cosmetic according to claim 1, wherein the extract of a genus Lindenium is an extract of a flower of a linden plant.