JPS5839620A - Alcohol composition - Google Patents

Abstract

PURPOSE:To provide the titled composition giving low stimulation to the body, by compounding ethanol and/or propanol with a food additive selected from polyhydric alcohol, specific amino acid and benzyl benzoate. CONSTITUTION:The objective alcohol composition is prepared by mixing ethanol and/or propanol with one or more compounds selected from (A) a polyhydric alcohol or its derivative permissible as a food additive or a drug additive (e.g. ethylene glycol, propylene glycol, etc.), (B) an amino acid having 1-2 carboxyl groups (e.g. glycine, alanine, etc.) and (C) benzyl benzoate. The addition of the above compounds eliminates the characteristic stimulation of alcohol to the skin and the oral mucosa, keeps the sterilizing effect of alcohol, and exhibits the effect for preventing the dental caries, cleaning the nicotine-stained tooth, and removing the oral odor.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a novel alcohol-kIl composition, which eliminates the O shavings characteristic of 1ρ pools against 1111 [41] in the skin and mouth, and exhibits the sterilizing and disinfecting action inherent to alcohol. At the same time, it is used to prevent tooth decay (in the car) and to remove bad breath (Ik*) and alcohol composition.

It is well known that ethanol and propanol have a sterilizing effect. However, tk-IIX et al. put it in their mouth) IIK to disinfect the wound.
It has the fatal drawback of imparting strong V% consistency to the skin and oral mucous membranes.

This Ij1Oa ceramic has the above-mentioned soft bacteria disinfection effect.
The object of the present invention is to provide an alcohol composition which eliminates the irritating properties of alcohol and does not substantially reduce the effect of the alcohol.

Another object of the present invention is to provide an alcohol composition that prevents dental caries and has a deodorizing effect on cigarettes.

The present inventor has conducted various studies for the above purpose, and as a result, has found that the following specific compound has the effect of eliminating the alcohol O stimulus, and furthermore, an alcohol composition containing a secondary compound has a caries preventive effect, The present invention has been completed based on these new findings, and the present invention has been completed based on these new findings.
> Propanol is blended with at least one selected from the group consisting of polyhydric alcohols or their derivatives that are acceptable as food additives or pharmaceutical additives, amino acids having one or two carboxyl groups, and benzyl benzoate. Pertains to non-irritating alcohol compositions using 9ζ7 as a tightening device.

The ethanol and purpanol used as main components in the alcohol composition of the present invention include ethanol 9 listed in the Japanese Pharmacopoeia, which is conventionally known as a sterilizing disinfectant.
&5 V/V% or more at t4, anhydrous F, /-#, I spring ethanol, isopropanol, and oboro-propanol can be exemplified. Compounds that can be blended with the above alcohol and exhibit the effects intended by the present invention are , which was independently selected by the present inventor as a result of intensive research from a wide range of compounds], and is composed of a specific O polyhydric alcohol or its 1lIII form, an amino acid having one or two carboxyl groups, and benzyl benzoate. belongs to the group The above polyhydric alcohols and II
Specific examples of the QF form and amino acids include the following compounds.

Polyhydric alcohols and their derivatives> Ethylene glycol, pyrene glycol, 1.8-
Butanediol, polyoxyalkylene glycol (polyoxyethylene glycol, polyoxypropylene glycol, etc.), polyoxyalkylene triol (polyoxypropylene triol 4I), glycerin, pentaerythritol, sorbitol, glucose, mannitol, 7-lactose, Sugar rumored alcohol and polyoxyethylene glycol oleate, glycerin heptanofatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan monooleate, sucrose fatty acid ester esters, and polyoxyethylene nonylphenol. Eta + 4' trouble etc.

Amino acids> Chrysin, alanine, phenylatunine, arginine,
Glutamic acid, aspartic acid, ζethylene, etc.

Each of the above-mentioned compounds may be used alone or in combination with one or more of the commonly available Form II (M1-form or liquid) forms to form the alcohol composition of the present invention. The blending ratio depends on the type and shape of the metal compound used.
It is resistant to alcohol, but in liquid form, it is 0 against alcohol.
．． 1-! 6V/V%, preferably t-20V/V91p
@FlOfllB 8h, "*9WA body 04e)"t'
is preferably o, osw/v% or more at 5 W/V** or until the saturation solubility of the substance, a, iw/v% or more than 10
W/V*t is preferably up to the saturation solubility of ore 040. The upper limit of the above blending ratio is not limited to the specific Kjl limit fk%, and the desired effect of the present invention can be achieved by using it beyond this limit, but normally, the more the above compound is blended, the more the composition obtained. There is a disadvantage that a large amount of the composition is required for use (as the alcohol content in the alcohol content decreases), but there is a disadvantage that a large amount of the composition is required for use. , this may not contribute to the desired effect of this I&IJi and may be wasted.

The original IjIOI11r thus obtained! 1. The object can be applied within the 110 cavity 41 thereof. The composition of the present invention can also be used in the form of a tincture by adding KW and Calicum to the skin, and is not particularly irritating. It also benefits the skin from KJI.

In addition, the composition of the present invention uses this as an active ingredient in combination with ordinary pharmaceutical carriers (excipients, diluents) 41, and further contains colorants, fragrances, demulcents, sweeteners, and other pharmaceuticals as necessary. After addition, it is shaped into strips of formulations such as granules, tablets, tablets, pastes, etc.
.

It can be made into a chewing gum type l141. The carrier and other additives used in i above may be any of the commonly used ones, and specific examples include starch, lucicum carbonate, sodium bicarbonate, crystalline cellulose, silicic acid, Fine particle anhydrous silica, kaolin, bentonite, talc, stearate, carboxymethylcellulose, methylcellulose, gelatin,
〆Livinylpyrrolidone, alginic acid, calcium phosphate, potassium phosphate, porous metasilicic acid, magnesium aluminate, vinyl acetate resin, menthol, thiol, chimney oil, Gui and sister, Hatsuka wave, menthol , detsukarin, etc. can be exemplified. The above-mentioned various Form O preparations can be prepared by conventional methods. For example, granules, tablets, etc.
After mixing the 891 composition with excipients and shaping, polyvinyl alcohol is added to prevent Albu A/D, which is the active ingredient, from volatilizing.
If necessary, it can be coated with stearicum or the like to give a gloss. The poultry and veterinary preparation is prepared by adding and mixing sweeteners, colorants, fragrances, etc. to the composition of the present invention, and diluting the mixture appropriately with water. Pastes or dentifrices are prepared by mixing the CMC 410 binder or thickening agent with the composition of the present invention and kneading therein fillers, extenders and other additives. Also, chewing gum
A chewing gum base material, such as vinyl acetate resin, is softened in advance with ethanol, and the composition of the present invention and, if necessary, a sweetener, Bara P+, etc. are mixed and soaked to form a porous material, such as porous metasilicic acid, aluminium silica, etc. The surface of the resulting molded product is coated with a polyvinyl alcohol film or the like and cut into an appropriate size to produce a plate-shaped KiE*L.

Each of the above product shapes flKl1m! The content of the composition of the present invention in the preparation, the form of the preparation, the method of use, the amount of application, and the desired amount
Although it is determined as appropriate and there are no particular restrictions, it is usually 60 parts by weight or more per unit of preparation, preferably 60 to 9
It is preferable to set it to 0 parts by weight li degree.

Each formulation thus prepared is applied in its form as follows. For example, a solid drug such as a tablet can be eaten or chewed in the mouth to have a cleaning and sterilizing effect on the oral cavity, a cavity prevention effect, and a dental cleaning effect for smoking, smoking, etc.
It has the effect of removing bad breath from the back of the mouth and the like. Such a solid agent is usually in the form of a unit of 1 to 8 f"0" and can be applied as appropriate when the desired effect is required.The liquid agent can be applied to the skin, etc. at the same cost as an ordinary sterilizing disinfectant. It can be applied in a regular manner, and has a soda-killing and body odor removal effect, and is used in combination with, for example, medicines that have a therapeutic effect on athlete's foot, or is applied in the form of a mixture with the active pharmaceutical ingredients. If so, it will be effective as a treatment for athlete's foot that does not cause irritation to the affected area.Such bactericidal disinfectants are usually applied to the skin in the form of a diluted solution with an alcohol concentration of about 10 to 80% by weight.
d right! IKIII can be applied in a range of about 6 to 10 sJ. In addition, the liquid agent for chopsticks for birds and animals is about 80 d at a time.
By rinsing around 8 times a day, it can have 410 effects, such as curing tonsilloma, cleaning teeth, removing bad breath, and preventing cavities due to its intraoral sinking action.

Toothpaste-type pharmaceutical companies usually apply about 2 to 8 f on a toothbrush 9 at a time (you should not brush your teeth more than 8115 L a day), and are proud that it can prevent cavities and have a soothing effect while smoking. It also helps remove bad breath. Furthermore, the medicine in the form of chewing gum can produce the same effect as the above-mentioned toothpaste by chewing 1 to 1 piece of it several times a day.

Various test examples conducted on the alcohol composition of the present invention are listed below. In addition, nine alcohol compositions used in each test,
Ethanol for disinfection (Ethanol 880) listed in the Japanese Pharmacopoeia
ydK purified water was added to the total amount, and predetermined amounts of each of the following compounds N & 1-46 were added and dissolved in 100s ZKs (prepared as 1000s). All of the above! However, if there are compounds that do not dissolve completely, please take a hot water bath.
After heating with CTC, the precipitates were removed by allowing it to cool and then using it in the form of a saturated liquid.<Test compound> ゛ □ Arashi seed chain 1 l,3-butanediol, 2 Bing Glycol 8 Propylene Glyfur Monooleate 4
Polyoxyethylene glycol 6 Polyoxypropylene glycol 6 Polyoxypropylene triol 7 Polyoxyethylene monooleate 8
Polyoxyethylene nonylphenol ether 9 Glycerin monooleate 10 K, Limethylolpropane fatty acid ester 1
1 benquerythritol 12 sorbitol 18 mannitol 14 polyoxyethylene sorbitan monooleate 16 sucrose 16 1, sucrose fatty acid ester 17 coupling sugar 18 glucose 7 19 fructose 20 glycine 21 alanine 22 L-aspartic acid 23 glutamic acid 24' alginic acid 26 L-arginine/L-glutamate 26
Benzyl benzoate The saturation solubility of the above test compounds 9.11 to 18.16% 16 and 20 to 24 was standard.

Test compound solubility (96) 9 0.16 -11 '1.11 131 1.67 18 1.60 16 1.67 16 0.6420
0.4011
0.4922 0.172
8 0.16j! 4
0.10 Test I Taste test (oral irritation test) Nine inventive composition products 1 were prepared by blending each of the above test compounds.
~26 (numbers correspond to the test compound) were put into the mouths of each test subject, consisting of 6 men and 6 women, and ') Check for presence of 1-geki in the mouth. The test was conducted 8 times for each person for each composition, and the results were determined according to the following criteria, and the average value of the 10 people is shown in Table 1 below.

Obi... Strong stimulation... Stimulation + ... Slight stimulation ± --- Very little stimulation --- No stimulation 111 table above No. 1 Table) Test compound Nagil～! ! 6 will eventually become 4
It is found that the oral irritation of the alcohol can be eliminated by dissolving it in disinfectant ethanol.

Test ■ Stimulus test on wounds It is well known that applying alcohol to a wound and letting it disappear will make the wound more sensitive to alcohol. This test was conducted to determine whether or not the sample composition of the present invention has irritation to wounds.

The results of wiping the uneven part of the finger or foot with cotton ti times and observing the irritation to the uneven part are shown in Table 2 below.

；゛・、゛1Pa1. Zeni -1- I^14-4 Table 2 The same test was carried out for compositions of the present invention N11 to 84, in which a predetermined amount of the test compound was blended with Impropatool 50s/, Ice-making 60-, and OII wave. ni':) The results of the discussion are shown in the *S table below.・Chapter sl Above! Tables I2 and IN8 show that the composition of the present invention also eliminates irritation to wounds and does not cause any irritation.

Test ■ Bactericidal effect test The bactericidal effect of the composition of the present invention on the following various microorganisms was tested.

<Test microorganism> A... Streptococcus mutans (St
r@ptococcus 'mutams)
B - Staphylococcus au lettuce (St
iphylococcws aurews)
Town C... Myopactericum tuberculosis (Mycobact*r1w tubercules
ig )D... Escherichia Puri (lEschsrlckla call)K
= ') Flokotsucus pneumoniae (Dlp)
lococcus pm@umo kneeling ia*)F
--- Pulmonella teifui (Silmome)
l1m typki) Large scale 1 of the composition of the present invention
Take 0Wt in a test tube, culture the above test microorganisms in it, add the culture solution is/, and after 1 second, transfer to the test tube.
Take a platinum loop, transfer it to the culture medium in another first test tube, and apply one platinum loop at a time to the wound for another 16 seconds with the culture medium in the first test tube in which the test microorganism is cultured. Snow collection, 8th
...Transplant into the culture medium in O test tube, and transfer each test tube sequentially to 87
The sample is incubated at ℃ for 2 days, and the presence or absence of growth of microorganisms is examined, and the time (seconds) during which growth is inhibited, that is, the sterilization time (seconds), is determined.

The amounts of each test compound in the composition of the present invention are shown in Table 4 below based on the average value obtained by repeating the same test 8 times.
A certain amount (6 to 1
5g 5Z, 6f (also saturated dissolved amount).

[Table 4] When alcohol was used alone in the above test, the time required to kill the sample microorganism AK was 80 seconds in the case of disinfectant fi/-#; 680 seconds for 60% isopropyl alcohol and 46 seconds for 60% n-propyl alcohol.

It is clear that all of the compositions of the present invention (see @Table 4 above) have strong bactericidal activity against the test microorganisms.

Test ■ Removal effect during test One end of the glass tube of No. 4118 ■ was closed with a piece of paper, and the smoke generated by the combustion of 8 pieces of cigarettes was passed through the glass tube using a pan at the other end. Pass the paper above. 1 paper becomes brown. This browned paper ii! =15111
In a circular shape! This is an EJIII test piece.

The above test piece has an inner diameter of 1! Put 61d of the composition of the present invention into an egg test tube and shake at a shaking width of 50 ws for 1 minute.
Shake 0 times at 41'e and observe the degree of decolorization of the test piece and the degree of coloration after 0 minutes. The results are shown in the 6th barley below.

Table IIs shows the case of using alcohol alone as a control and the case of using p-ami7benzenbarashun methyl and ethyl nalicylate, which have been proposed to be effective (conventional) for comparison. Also include the results.

Table 6 [Table 6 above] It is clear that the composition of the present invention has a harmful effect when burning tobacco.

Test Ma: Deodorizing Effect Test A person who can smell a strong garlic odor immediately after eating a commercially available Gisoori De was asked to brush his/her teeth for 1 minute with a toothbrush using Composition 8- of the present invention. As a result, there was no smell of garlic at a distance of 1 (11 meters).

★Similarly, human Wc') who can feel a strong garlic odor after eating commercially available gi Wf de, IlM with 80d of the composition of the present invention
After gargling, I could not detect any garlic odor even though I got within 1Qs of it.

From the above test, it is clear that the composition of the present invention has a bad breath removal effect.

Below, 810,000 examples of the alcohol composition 0I of the present invention are listed as examples.

Example 1 Ethanol for Disinfection 1000@t Propylene Glycol 601 Propylene glycol was added and dissolved in ethanol for disinfection to obtain the composition of the present invention in a liquid form.

Example! Disinfecting ethanol 100 G+wJL-Alanine 50F Disinfecting ethanol KL
- Add alanine and dissolve by heating to 80° C. on a hot water bath, and after cooling to room temperature, insoluble matter is removed to obtain a composition of the present invention in a liquid form.

Example 8 Disinfectant Ethanol No. (Is+J Saccharide Fatty Acid Aesthetic #601 Same as Example 2)
The composition of the present invention in liquid form is obtained.

Example 4 M 6・fWIt potassium 40170% (V/V) zl/-
k eTSm glycerinmine noolea)
6170% (V/V'') ethanol-A/ is mixed with glycerin oleate, dissolved on a hot water bath, left to cool, the insoluble matter is P*, and Fi liquid KW?
In addition, a composition of the present invention in the form of a day-F tincture and gold sculpture is obtained.

Example 6 l-((lazy-chloroWphenyl)ditzenylmethyl)imidazole lOI disinfectant ethanol
1000s/L-alanine 50f
Nine liquid Kl obtained by dissolving L-alanine in disinfectant ethanol
-((!-ChloW phenyl)diphenylmethylcoimidazole is added and dissolved in tklI, which is effective as a water wheel treatment agent.
A L dosage form II molded inventive composition is obtained.

Example 6 1 Proper Tool 1001 Natsukarin
II Erythrosine
o, ott menthol o, ogy-
The above chemicals are mixed to obtain a mouthwash form IIO composition of the present invention.

If you dilute this drug appropriately with water and wash your mouth and mouth, it will kill the microorganisms in your mouth that are the cause of tooth decay, and it will kill the microorganisms in your mouth that are the cause of tooth decay. It has the effect of not only eliminating bad breath but also preventing swelling of the tonsils.

How many chlorohexidine and 4f menthol! ! f chi peak - rules
'LUI Chokji Oil
1.・F cinnamon oil
8f Ethanol for consumption tooIII
The animal mouth detergent of the present invention is prepared by mixing and dissolving polyoxyethylene glycol 601 or more. This can produce the same effect as in Example 6.

Example 8 Ethanol for disinfection 1001 polyoxyethylene glycol! 81 mold particles anhydrous silica
Toe detsukarin
0.6F heart oil 0.61
The above O chemical is uniformly kneaded to obtain a viscous paste-like IIO composition of the present invention.

This can be done by soaking a rotary brush attached to a dental engine in a dental clinic, rotating it, and applying it to teeth contaminated with cigarette tar to remove the cigarette tar from the teeth and make them clean. Strep) Putukasumietans 410 is effective in killing microorganisms, preventing tooth decay, and eliminating bad breath.

Example 9 Disinfecting ethanol 100f propylene glycol gOf fine particle anhydrous silica
70f Satukarin 0
．． 6f Core oil 0.61 In the same manner as in Example 7, a composition of the present invention in the form of a paste of Jokigumi 2 was obtained.

Example, 10 99.6% (V/V) 757 Griyari, 16fC, M, C
, got alanine ml fructose 6f calcium carbonate
1001 Calcicum phosphate dihydrate 1
oor menthol 0.6f water
! I
Disperse s/C, M, and C in glycerin in advance, then mix with water to make a viscous paste, add ethyl alcohol to this, and dissolve alanine, 7-tox, and benzoic acid salt. Then, calcium carbonate and calrecum phosphate dihydrate are mixed to form a uniform paste, and finally, Kl is added and mixed to obtain a toothpaste-type flO composition of the present invention. It is effective in removing bad breath caused by garlic and other contaminants caused by cigarette tar.

Example 11 Ethanol for disinfection! Got glycerin monomonooleate 101 turactose
61 panic blended fragrance
51d porous metasilicate aluminate 1000
f Magnesicum (Inocillin) Vinyl acetate resin Toooy Disinfectant ethanol, glycerin monooleate, and fragrance are mixed with Metagui-tested alumin-Shun magnesicum and absorbed and saturated into the porous interior of Metagui-tested alumin-Shun magnesicum, and this is separately mixed with disinfectant ethanol. The product is kneaded in softened vinyl acetate resin, distributed to a certain thickness, and the front and back of the plate-shaped tLWM product is covered with polyvinyl alcohol film, etc. to prevent the disinfectant ethanol from volatilizing and cut into appropriate sizes. A chewing gum-shaped composition of the present invention is obtained.

By chewing this chukuinga, you can prevent dental caries, remove tooth stains caused by tobacco tar, and remove bad breath caused by garlic and other substances.

Example 1g Disinfecting ethanol 20017 Tuctose 101 Alginic acid
o, gf porous metal aluminic acid
1500Ii Gnesicum (Neushilin) Menthol 0.1fM! 'M
50fI Sho MPM
is 2-methyl-6-vinylpyridine-methyl acrylate, methacrylic acid, and O copolymer (manufactured by Tanabe Seiyaku Co., Ltd.).

Disinfecting ethanol, 7-tuctose, alginic acid, and menthol are mixed and dissolved to make a homogeneous solution, and porous metal aluminium magnesium is mixed with this, and the porous interior is soaked, and a small amount of MPM is added to this. After adding a viscous liquid dissolved in alcohol and mixing it, it is made into granules or tablets and coated with polyvinyl alcohol to prevent evaporation of ethanol, and the surface is made glossy with calcium stearate. The composition of the present invention in the form of granules or tablets is obtained by applying it. This prevents tooth decay by constantly chewing it, and it also prevents tooth decay by applying P# with tobacco tar to make the round teeth look cloudy and smell like garlic. It has the effect of eliminating.

(Above) 1. Indication of the case 1982 Patent Application No. 1! 19274 3. Person making the amendment 4. Agent Telephone number 06-203 in Heiwa Building, 2-10 Hirano-cho, Higashi-ku, Osaka City
-0941 (generation) 8, Contents of the amendment As shown in the attached sheet, Contents of the amendment (1) The description in the specification will be corrected in the regular schedule below.

(2) The description of the amount added below for the following sample composition in Table 1 on pages 16 to 17 of the specification is corrected as follows.

(3) “Test composition A16” in Table 2 on page 19 of the specification
(4) [Test composition A3 in Table 3 on page 20 of the specification]
0J, "Amount of test compound added (/100m#)"
1.67 f (saturated)'' is corrected to ``ro, 54F (saturated)'' and the ``5f'' in the same section of ``Test Composition A32'' is corrected to ``ro, 49F (saturated)''.

(that's all)

Claims (1)

[Scope of Claims] ■ Ethanol and/or glopanol contain polyhydric altyl which is acceptable as a food additive or pharmaceutical additive.
%L, , < is a derivative thereof, which is formulated with at least one member of the group consisting of one or more carboxyl group-containing amino acids and benzyl derivatives. Alco J & Jl is a powerhouse with a sense of humor. ■ #hydric alcohols or owe alcohols have 1 hydroxyl group
Claim I which is an ether or ester thereof having one arboul or its ether or ester! Oag product described in item 1. ■ Polyhydric alcohol A/O derivatives include ethylene glycol, propylene glycol, and l. 8-butanediol, polyoxyalkylene glycol, polyoxyalkylene triol, glycerin, pentaerythritol, sorbitol, glucose, mannilla), 79-su, salt, polyoxyethylene dioleate, glycerin heptanofatty acid ester , propylene glyfur fatty acid ester, polyoxyethylene sorbitan monooleate, sucrose fatty acid ester, polyoxyethylene nonylphenol ether, and trimethylolpropane fatty acid ester, claim a.
The composition according to claim 0111111111 selected from glylene, alanine, phenylalanine, arginine, glutamic acid, aspartic acid and sutidine as described in SS paragraph 8. ■ Claims that are cleaning, deodorizing, sterilizing, and disinfecting agents
Collection 11 [KE described composition. ■ Liquid engraving, seal-do tincture yg11. Animal agent Horiken,
111181. The KE-cut O composition of claim 111181, which is used in paste form, toothpaste form, and chain gum form.