CN116172886A - Mouthwash and preparation method thereof - Google Patents

Mouthwash and preparation method thereof Download PDF

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Publication number
CN116172886A
CN116172886A CN202210758575.4A CN202210758575A CN116172886A CN 116172886 A CN116172886 A CN 116172886A CN 202210758575 A CN202210758575 A CN 202210758575A CN 116172886 A CN116172886 A CN 116172886A
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parts
mouthwash
water
solution
sucralose
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何道牛
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Guangzhou Hejitang Biotechnology Co ltd
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Guangzhou Hejitang Biotechnology Co ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract

The invention provides a mouthwash and a preparation method thereof, wherein the mouthwash comprises a mixed medicine and water, the weight percentage of the mixed medicine in the mouthwash is 0.3-0.4%, and the balance is water; the mixed medicine comprises the following components in parts by weight: 2 to 10 parts of cetylpyridinium chloride, 5 to 15 parts of polyhexamethylene biguanide hydrochloride and 1.5 to 4 parts of sucralose. The cetylpyridinium chloride is used as an active agent for inhibiting bacteria, and the polyhexamethylene biguanide hydrochloride is used for sterilizing, and the two are matched cooperatively, so that bacteria in the oral cavity cannot be immediately regenerated after being killed, and the effects of sterilization and protection are achieved.

Description

Mouthwash and preparation method thereof
Technical Field
The invention relates to the field of mouthwashes, in particular to a mouthwash and a preparation method thereof.
Background
The mouthwash is an oral product for cleaning and health care in daily life, and is mainly used for keeping the oral cavity and teeth clean, promoting breath freshening, nursing gums, maintaining good microenvironment of the oral cavity and the like.
Gingivitis, bleeding and swelling and pain of gums are typical periodontal disease symptoms, and according to statistics, ninety-seven percent of people in China have periodontal diseases, the periodontal diseases are one of main reasons for losing teeth of people over thirty-five years old. Improving oral health has become an important and difficult task in the field of oral health in China.
Gingivitis is a common periodontal tissue disease. The oral hygiene is caused by the long-term irritation of teeth caused by soft tartar and hard tartar formed by food residues around teeth, bacteria and the like, incorrect tooth brushing habit, vitamin deficiency and the like. The periodontal health rate of people in the age range of 35 years old to 44 years old is 14.5%, the city is higher than that in rural areas, the women are higher than that in men, and the western area is the highest; the detection rate of gum bleeding is 77.3%, the number of teeth with gum bleeding in people is 8.77, women are higher than men, urban and rural areas are not different, and the middle area is the highest; the periodontal pocket detection rate is 40.9%, the city is lower than rural area, the male is higher than the female, and the middle area is the highest; the detection rate of the adhesion loss equal to or greater than 4 mm is 38.9%, the male is higher than the female, the urban and rural areas are not different, and the eastern area is the highest.
The main reasons for various problems in the oral cavity are that a large amount of bacteria are contained in the oral cavity, and bacteria are easy to generate in the oral cavity, so that the mouthwash is designed for sterilization and bacteriostasis, and the oral cavity of a person is protected.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, and provides mouthwash and a preparation method thereof.
In order to solve the technical problems, the invention adopts the following technical scheme: the mouthwash comprises a mixed medicine and water, wherein the weight percentage of the mixed medicine in the mouthwash is 0.3-0.4%, and the balance is water;
the mixed medicine comprises the following components in parts by weight: 2 to 10 parts of cetylpyridinium chloride, 5 to 15 parts of polyhexamethylene biguanide hydrochloride and 1.5 to 4 parts of sucralose.
Further, the mixed medicine comprises the following components in parts by weight: 3 to 7 parts of cetylpyridinium chloride, 8 to 13 parts of polyhexamethylene biguanide hydrochloride and 2 to 3.5 parts of sucralose.
Further, the mixed medicine comprises the following components in parts by weight: 5 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride and 2.5 parts of sucralose.
Further, the mixed medicine also comprises 5-15 parts of citric acid.
Further, the mixed medicine also comprises 5-15 parts of odorless water-soluble cooling agent.
A method for preparing mouthwash, the method comprising:
putting a preset amount of water into the preparation cup;
sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components;
after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Cetylpyridinium chloride is a cationic quaternary ammonium compound that acts as a surfactant to inhibit and kill bacteria, primarily by reducing surface tension. The in vitro test result shows that the cetylpyridinium chloride has the effects of inhibiting and killing various oral pathogenic and non-pathogenic bacteria. Can reduce or inhibit the formation of dental plaque after being rinsed; has effects in keeping clean oral cavity and eliminating halitosis. Animal test results show that the product has no obvious irritation to oral mucosa.
Polyhexamethylene biguanide hydrochloride (PHMB) hydrochloride is an environment-friendly high polymer disinfectant. It has the advantages of broad-spectrum sterilization, low effective concentration, quick effect, stable property and good water-soluble property, and is the safest and effective bactericide at present. Polyhexamethylene biguanide hydrochloride (PHMB) is a polyguanide high molecular polymer, can generate ionization in aqueous solution, has strong electropositivity in a hydrophilic group part, and can rapidly adsorb various bacteria and viruses which are usually electronegative. Polyhexamethylene biguanide hydrochloride (PHMB) can enter the cell membrane of microorganisms, and the optimal sterilization effect is achieved by inhibiting the synthesis of liposome in the membrane to cause the apoptosis of pathogenic bacteria. The cetylpyridinium chloride is used as an active agent to inhibit bacteria, and the polyhexamethylene biguanide hydrochloride is used for sterilization, and the two are matched with each other, so that bacteria in the oral cavity cannot be immediately regenerated after being killed, and the effects of sterilization and protection are achieved.
Sucralose is one of the halogenated sucrose derivatives, also known as "super sweet sucrose," and its chemical name is 4,1',6' -trichloro-4, 1',6' -trideoxygalactosucrose. The sucralose is called sucralose, and the sucrose is used for preparing a non-caloric high-power sweetener substance, has the characteristics of no odor, no hygroscopicity and the like, has higher thermal stability, is very easy to dissolve in water, and can be dissolved in organic solvents such as ethanol, methanol and the like. The solubility was 28.2g at 28℃at room temperature. The stability under the conditions of light environment, heat environment and pH value change is higher. The aqueous solution of the sucralose is clear and transparent, the pH of the aqueous solution is 5, the stability is higher, and the chemical change can not occur after the storage for more than 1 year. The crystal can not generate chemical change after being stored for about 4 years, and the sweetness can not be changed under the high temperature condition. Has excellent performance and belongs to non-nutritive high intensity sweetener. The sweetness of the sucralose is very high (400-800 times of that of the sucrose), the sweetness is pure, the sweetness is expressed at a speed, the maximum sweetness perceived intensity, the sweetness duration time, the aftertaste and the like are very similar to those of the sucrose. Sucralose is stable in nature and its crystalline product is also stable for 4 years under dry conditions at 20 ℃. In aqueous solution, sucralose is the most stable one of all intense sweeteners in the pH range of soft drinks and at normal temperatures, and can be stored for more than one year without any change. Sucralose is a derivative of pure natural product sucrose, has a desalination effect on sour taste and salty taste, has a masking effect on astringent taste, bitter taste, vinosity and other tastes, and has a synergistic effect on spicy taste, milky taste and the like. In order to prevent the mouthwash from having a certain taste when in use and simultaneously enhance the comfortable mouth feel, the addition of sucralose increases the comfort of the mouthwash when in use.
Citric Acid (CA), also known as citric acid, has a molecular formula of C 6 H 8 O 7 Is an important organic acid, is colorless crystal, odorless, has strong sour taste, is easy to dissolve in water, and is an acidity regulator (GB 2760-2014) and a food additive. The citric acid has the characteristics of chelation and pH value adjustment, so that the citric acid can increase the performance of an antioxidant, inhibit the enzyme activity and prolong the storage life of the food in the processing of quick-frozen food. Can prolong the service life of the mouthwash. And citric acid also has calcium removing effect, and can be used for cleaning foreign matters on tooth surface.
The odorless water soluble cooling agent is any one of synthetic Borneolum Syntheticum, herba Menthae derivatives, synthetic Camphora and Camphora derivatives. The produced cool feel makes the gargle maintain cool effect for a long time after rinsing.
Compared with the prior art, the invention has the beneficial effects that: the cetylpyridinium chloride is used as an active agent to inhibit bacteria, and the polyhexamethylene biguanide hydrochloride is used for sterilization, and the two are matched with each other, so that bacteria in the oral cavity cannot be immediately regenerated after being killed, and the effects of sterilization and protection are achieved. Sucralose prevents the mouthwash from having a certain taste when in use, and at the same time enhances the mouth feel. Citric acid can enhance the useful life of the mouthwash. And citric acid also has calcium removing effect, and can be used for cleaning foreign matters on tooth surface. The tasteless water-soluble cooling agent can generate cooling feeling, so that the mouthwash can maintain cooling effect for a long time after rinsing.
Drawings
The disclosure of the present invention is described with reference to the accompanying drawings. It is to be understood that the drawings are designed solely for the purposes of illustration and not as a definition of the limits of the invention. In the drawings, like reference numerals are used to refer to like parts. Wherein:
FIG. 1 schematically shows a schematic representation of a drug mixture and water formulation according to one embodiment of the present invention;
fig. 2 schematically shows a schematic diagram of the component ratios of the drug blend according to one embodiment of the present invention.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.22% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 4 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of sucralose, 10 parts of citric acid and 10 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 1:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.22% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 4 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of sucralose, 10 parts of citric acid and 10 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent
Example 2:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.4% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 4 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of sucralose, 10 parts of citric acid and 10 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent
Example 3:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.56% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 4 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of sucralose, 10 parts of citric acid and 10 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent
Example 4:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.3% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 2 parts of cetylpyridinium chloride, 13 parts of polyhexamethylene biguanide hydrochloride, 1.6 parts of sucralose, 10 parts of citric acid and 12 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 5:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.4% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 10 parts of cetylpyridinium chloride, 15 parts of polyhexamethylene biguanide hydrochloride, 3.1 parts of sucralose, 10 parts of citric acid and 7 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 6:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.5% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 8 parts of cetylpyridinium chloride, 5 parts of polyhexamethylene biguanide hydrochloride, 3.5 parts of sucralose, 7 parts of citric acid and 7 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 7:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.4% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 7 parts of cetylpyridinium chloride, 11 parts of polyhexamethylene biguanide hydrochloride, 1.5 parts of sucralose, 7 parts of citric acid and 11 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 8:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.45% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 7 parts of cetylpyridinium chloride, 15 parts of polyhexamethylene biguanide hydrochloride, 4 parts of sucralose, 7 parts of citric acid and 9 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 9:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.3% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 8 parts of cetylpyridinium chloride, 15 parts of polyhexamethylene biguanide hydrochloride, 3.5 parts of sucralose, 5 parts of citric acid and 15 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent
Example 10:
an embodiment of the mouthwash of the present invention comprises the following ingredients in weight percent:
0.36% of mixed medicine and the balance of water;
wherein the mixed medicine comprises the following components in percentage by weight: 8 parts of cetylpyridinium chloride, 15 parts of polyhexamethylene biguanide hydrochloride, 3.5 parts of sucralose, 15 parts of citric acid and 5 parts of odorless water-soluble cooling agent.
The preparation method of the mouthwash comprises the following steps:
putting a preset amount of water into the preparation cup; sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components; after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
Example 11:
in order to further prove that the mouthwash has the effects of bacteriostasis, sterilization and good taste, the embodiment combines experimental researches to prove that the mixed medicine mouthwash has the effects of bacteriostasis, sterilization and good taste.
1. Test drugs and groups
Control group: common mouthwash (without cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid, odorless water soluble cooling agent, and other preparation methods are consistent with the invention)
Experimental group: the mouth wash product provided by the dispensing and preparation method of the invention.
2. Study object and group
50 gingivitis patients were selected for oral hospital visits, aged 18-45 years. Of these, 21 men and 29 women. The following conditions are met: the health condition of the whole body is good, and the total mouth is not less than 20 functional teeth; red and swollen gums, obvious bleeding detection; voluntarily taking part in the study, and only using the cavity care product provided by the study; antibiotics and hormone were not taken for 3 months; no systemic disease.
The 50 patients with gingivitis and gingival bleeding are randomly divided into a test group and a control group (25 cases in each group), the test group contains mouthwash according to grouping requirements after basic oral care is finished in the morning and evening every day, 20ml of mouthwash is carried out each time, 30s are carried out, and diet is not obtained in 30 minutes of mouthwash. The 2 groups of subjects were asked to use a uniform toothpaste and toothbrush, each time the length of toothpaste was used, the toothbrush head was covered, each time for 2 minutes. For a period of 1 month.
2.2 inspection Standard
Each subject examined 6 dental sites (16, 21, 24, 36, 41, 44), 4 sites per tooth: the plaque index (PLI), gum Index (GI), bleeding Index (BI) were measured and recorded separately on the mesial, median, distal cheek side and on the mesial lingual side, and the average was taken as the clinical index of the index.
2.3 results
Plaque index, gum index and bleeding index of 2 groups of patients examined at 2 weeks and 1 month.
The plaque index, gum index and bleeding index are respectively reduced by 8%, 14% and 34% compared with the control group at 2 weeks; the plaque index, gum index and bleeding index were reduced by 32%, 40% and 45% respectively compared with the control group at one month. Test groups using the combination drug were compared to baseline. From the data, the mouth wash containing the mixed medicine provided by the invention has obvious treatment effects on gingivitis, gingival bleeding and other oral problems, and can be used as an auxiliary cleaning product for daily oral care. In addition, the effects of bacteriostasis, sterilization, hemostasis and gingivitis treatment are more remarkable.
Example 12
The treatment effect of the mouthwash prepared by the invention on recurrent oral ulcer is researched and analyzed.
1. General data: the patients with recurrent oral ulcer were selected from 40 cases, 27 men and 13 women, and the patients in this group were divided into two groups based on the control, double-blind and randomized principles, namely, the observation group (20 cases) and the control group (20 cases). The disease conditions, ages, sexes and the like of the two groups of patients are comparable, and the statistical significance does not exist.
2. The method comprises the following steps: patients in the control group were given vitamin B2 tablets for treatment 3 times a day, 2 tablets each time. The plant essential oil mouthwash provided by the invention is given to an observation group for treatment, and the treatment is carried out 2-3 times a day, and about 20ml each time. Both groups of patients continued to be treated for 20 days.
3. Efficacy assessment: the effect is shown: the local causalgia disappears, the ulcer surface heals completely, and no recurrence occurs after 6 months of follow-up. The method is effective: recurrence is carried out within 6 months after follow-up, but the intermittent period of recurrence is prolonged, the local causalgia is obviously relieved, the ulcer surface is relieved to some extent, and the recurrence frequency is reduced. Invalidation: clinical symptoms were not relieved or even worsened.
4. Results
The observation group shows 7 cases (35.0%), 12 cases (60%), 1 case (5.0%) and the total effective rate is 95.0%; the control group shows 3 cases (15.0%), 12 cases (60.0%), 5 cases (25.0%) and 75.0% of total effective rate, and the effective rates of the two groups of patients are obviously different after treatment, so that the mixed medicine mouthwash provided by the invention has good curative effect on recurrent oral ulcer treatment, and can effectively relieve oral problems of oral ulcer and sore throat of patients.
Example 13
1. The experimental method comprises the following steps: 30 volunteers were selected and randomly divided into three groups, and each group was subjected to 1 month anticaries experimental observation with the mixed drug mouthwash of the present invention (test group A: the mouthwash composition and preparation method thereof are the same as those of example 2 of the present invention, test group B: the mouthwash composition and preparation method thereof are the same as those of example 8 of the present invention), and the control group (the mouthwash does not contain cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid, odorless water-soluble cooling agent, and the other components are the same as those of example 4) and the mouthwash is 20ml after brushing teeth every morning and evening for 30 seconds. The observation is that streptococcus mutans accounts for the percentage of total anaerobes before and after the experiment.
2. Results
According to the measurement results, the proportion of the streptococcus mutans in the test group and the comparison group after the experiment is reduced to different degrees, but the reduction of the proportion of the two groups is obviously different, the reduction proportion of the test group A, B is respectively 72.5 percent and 68.7 percent, and the reduction proportion of the comparison group is 42.1 percent, which indicates that the mouthwash can effectively kill the streptococcus mutans in the oral cavity, thus obviously inhibiting the growth of the streptococcus mutans in dental plaque and having the effect of specific caries prevention.
According to the experimental study data of the comprehensive examples 11-13, the mixed medicine mouthwash provided by the invention has obvious sterilization and bacteriostasis effects, has the functions of diminishing inflammation and freshening air, and can be used for preventing or treating periodontitis, gingival bleeding, decayed tooth or other oral diseases. In addition, according to experimental research results, the mouthwash containing cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent has more remarkable curative effects on preventing and treating oral problems and is healed more quickly. Therefore, in the preparation process of the mouthwash, the mixed medicine is added, so that the aim of enhancing the treatment effect is fulfilled, the citric acid has the calcium effect and plays a role of removing impurities, and the sucralose and the odorless water-soluble cooling agent can enable the mouthwash to have better taste and be accepted by consumers easily.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.

Claims (6)

1. The mouthwash is characterized by comprising mixed medicines and water, wherein the weight percentage of the mixed medicines in the mouthwash is 0.2-0.6%, and the balance is water;
the mixed medicine comprises the following components in parts by weight: 2 to 10 parts of cetylpyridinium chloride, 5 to 15 parts of polyhexamethylene biguanide hydrochloride and 1.5 to 4 parts of sucralose.
2. A mouthwash according to claim 1, wherein the combination comprises the following components in parts by weight: 3 to 7 parts of cetylpyridinium chloride, 8 to 13 parts of polyhexamethylene biguanide hydrochloride and 2 to 3.5 parts of sucralose.
3. A mouthwash according to claim 2, wherein the combination comprises the following components in parts by weight: 5 parts of cetylpyridinium chloride, 10 parts of polyhexamethylene biguanide hydrochloride and 2.5 parts of sucralose.
4. A mouthwash according to any of claims 1-3, wherein the combination further comprises 5-15 parts citric acid.
5. A mouthwash according to claim 4 wherein the combination further comprises 5 to 15 parts of a non-odorous water soluble cooling agent.
6. A method of preparing a mouthwash according to any one of claims 1 to 3 or 5, characterized in that the method is:
putting a preset amount of water into the preparation cup;
sequentially pouring cetylpyridinium chloride, polyhexamethylene biguanide hydrochloride, sucralose, citric acid and odorless water-soluble cooling agent with preset components into the preparation cup, and continuously stirring the solution when adding the components;
after all the components are poured into the preparation cup, continuously stirring the solution, observing whether the solution is transparent, and obtaining the mouthwash when the solution is transparent.
CN202210758575.4A 2022-06-29 2022-06-29 Mouthwash and preparation method thereof Pending CN116172886A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560906A (en) * 1995-03-27 1996-10-01 Oral Technology Laboratories, Inc. Non-alcoholic antimicrobial mouthwash for removal of dental plaque
CN101253235A (en) * 2005-08-31 2008-08-27 金伯利-克拉克环球有限公司 Antimicrobial composition
CN106176315A (en) * 2016-08-27 2016-12-07 广东罗浮山国药股份有限公司 A kind of collutory and preparation method thereof
CN109562045A (en) * 2016-08-11 2019-04-02 高露洁-棕榄公司 Oral care composition
CN109674875A (en) * 2019-03-01 2019-04-26 中山市怡口康科技有限公司 Oral ulcer nursing essence
CN110433117A (en) * 2019-08-30 2019-11-12 武汉品瑞医学科技有限公司 Mouthwash and preparation method thereof
CN113197786A (en) * 2021-04-20 2021-08-03 苏州清馨健康科技有限公司 Oral bacteriostatic composition, mouth wash composition, preparation method and application thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560906A (en) * 1995-03-27 1996-10-01 Oral Technology Laboratories, Inc. Non-alcoholic antimicrobial mouthwash for removal of dental plaque
CN101253235A (en) * 2005-08-31 2008-08-27 金伯利-克拉克环球有限公司 Antimicrobial composition
CN109562045A (en) * 2016-08-11 2019-04-02 高露洁-棕榄公司 Oral care composition
CN106176315A (en) * 2016-08-27 2016-12-07 广东罗浮山国药股份有限公司 A kind of collutory and preparation method thereof
CN109674875A (en) * 2019-03-01 2019-04-26 中山市怡口康科技有限公司 Oral ulcer nursing essence
CN110433117A (en) * 2019-08-30 2019-11-12 武汉品瑞医学科技有限公司 Mouthwash and preparation method thereof
CN113197786A (en) * 2021-04-20 2021-08-03 苏州清馨健康科技有限公司 Oral bacteriostatic composition, mouth wash composition, preparation method and application thereof

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