CN116509745A - Novel mouthwash and preparation method thereof - Google Patents
Novel mouthwash and preparation method thereof Download PDFInfo
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- CN116509745A CN116509745A CN202310495095.8A CN202310495095A CN116509745A CN 116509745 A CN116509745 A CN 116509745A CN 202310495095 A CN202310495095 A CN 202310495095A CN 116509745 A CN116509745 A CN 116509745A
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 56
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 108010015776 Glucose oxidase Proteins 0.000 claims abstract description 27
- 239000004366 Glucose oxidase Substances 0.000 claims abstract description 27
- 229940116332 glucose oxidase Drugs 0.000 claims abstract description 27
- 235000019420 glucose oxidase Nutrition 0.000 claims abstract description 27
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 22
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 22
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 22
- 239000011425 bamboo Substances 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 22
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 17
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 16
- DCWBLFMYZJBXPI-UFLZEWODSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;(2,5-dioxoimidazolidin-4-yl)urea Chemical class NC(=O)NC1NC(=O)NC1=O.N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 DCWBLFMYZJBXPI-UFLZEWODSA-N 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 11
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 11
- 239000003906 humectant Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 10
- -1 ascorbyl ether Chemical compound 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 9
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 6
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 6
- 241001330002 Bambuseae Species 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 210000000214 mouth Anatomy 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 241001558929 Sclerotium <basidiomycota> Species 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
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- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 abstract description 9
- 206010061218 Inflammation Diseases 0.000 abstract description 8
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 230000029663 wound healing Effects 0.000 abstract description 6
- 230000002087 whitening effect Effects 0.000 abstract description 5
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- 231100000252 nontoxic Toxicity 0.000 abstract description 4
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- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 244000082204 Phyllostachys viridis Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 42
- 230000000052 comparative effect Effects 0.000 description 25
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- 230000000844 anti-bacterial effect Effects 0.000 description 13
- 238000009472 formulation Methods 0.000 description 12
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 10
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- 208000007565 gingivitis Diseases 0.000 description 7
- 230000004054 inflammatory process Effects 0.000 description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
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- 238000012360 testing method Methods 0.000 description 5
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- 241000186044 Actinomyces viscosus Species 0.000 description 3
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- 230000002195 synergetic effect Effects 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 241000202726 Bupleurum Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 206010048685 Oral infection Diseases 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 241001146210 Senecio scandens Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 230000036570 collagen biosynthesis Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011841 epidemiological investigation Methods 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960005053 tinidazole Drugs 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000036344 tooth staining Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/66—Enzymes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses novel mouthwash and a preparation method thereof. The mouthwash consists of the following components in percentage by mass: 0.5 to 1.5 percent of aluminum cloxate, 1 to 5 percent of glucose oxidase, 1 to 3 percent of allantoin biotin salt, 4 to 8 percent of bamboo salt, 3 to 5 percent of 3-O-ethyl ascorbyl ether, 0.1 to 0.3 percent of lemon peel powder and sclerotium rolfsii, 4 to 8 percent of humectant, 0.5 to 1 percent of solubilizer, 0.1 to 0.5 percent of edible essence and the balance of deionized water. The mouthwash disclosed by the invention is safe and nontoxic in each component, low in irritation, excellent in sterilization, anti-inflammation, wound healing promoting and tooth whitening effects, capable of effectively preventing and treating various oral inflammatory diseases, and is a novel multifunctional oral care product.
Description
Technical Field
The invention belongs to the technical field of oral care products, and particularly relates to novel mouthwash and a preparation method thereof.
Background
Oral inflammatory disease is a common and frequently occurring disease, and almost everyone experiences oral inflammatory disease. Common oral inflammatory diseases include canker sores, gingivitis, periodontitis, halitosis, and the like.
The current method for preventing and treating the oral inflammatory diseases mainly comprises the steps of chemical mouthwash rinsing and traditional Chinese medicine extract mouthwash rinsing. The chemical gargle contains povidone iodine, chlorhexidine acetate, cetylpyridinium chloride, tinidazole and other components, has a strong and broad-spectrum sterilization effect, but has poor taste, large irritation to mucous membrane, easy discomfort and possibility of causing the imbalance of normal flora of the oral cavity after long-term use. The traditional Chinese medicine extract mouthwash contains many components such as clove, astragalus root, honeysuckle, senecio scandens, bupleurum, liquorice and the like, has a certain effect on keeping the oral cavity clean and preventing oral infection, but the mouthwash containing the traditional Chinese medicine extract has a deep color, can cause tooth staining when being frequently used, and has more complex components, so that the problems of turbidity, precipitation, reduced efficacy and the like of the mouthwash in the storage process are easy to occur.
Aiming at the problems of large side effect, uncomfortable use, unstable efficacy and the like of the existing mouthwash, the need for searching the mouthwash with small side effect, stable efficacy and comfortable taste is urgent, and the public demand is met while the good mouth protection effect is achieved.
Disclosure of Invention
The invention aims to provide novel mouthwash and a preparation method thereof. The mouthwash has the advantages of safe and nontoxic components, low irritation, excellent effects of sterilizing, diminishing inflammation, promoting wound healing and whitening teeth, can effectively prevent and treat various oral inflammatory diseases, and is a novel multifunctional oral care product.
The invention is realized by the following technical scheme:
the novel mouthwash consists of the following components in percentage by mass: 0.5 to 1.5 percent of aluminum cloxate, 1 to 5 percent of glucose oxidase, 1 to 3 percent of allantoin biotin salt, 4 to 8 percent of bamboo salt, 3 to 5 percent of 3-O-ethyl ascorbyl ether, 0.1 to 0.3 percent of lemon peel powder and sclerotium rolfsii, 4 to 8 percent of humectant, 0.5 to 1 percent of solubilizer, 0.1 to 0.5 percent of edible essence and the balance of deionized water.
Preferably, the novel mouthwash consists of the following components in percentage by mass: 1% of aluminum cloxate, 4% of glucose oxidase, 2% of allantoin biotin salt, 6% of bamboo salt, 4% of 3-O-ethyl ascorbyl ether, 0.2% of lemon peel powder and sclerotium rolfskin, 6% of humectant, 1% of solubilizer, 0.5% of edible essence and the balance of deionized water.
Preferably, the humectant is one or any combination of glycerin, xylitol and sorbitol.
More preferably, the humectant is glycerin.
Preferably, the solubilizer is PEG-40 hydrogenated castor oil or polysorbate.
More preferably, the solubilizing agent is PEG-40 hydrogenated castor oil.
Preferably, the edible essence is green tea essence, lemon essence, sweet orange essence or peppermint essence.
The preparation method of the novel mouthwash comprises the following steps:
(1) Dissolving a solubilizer in part of water according to a formula, adding allantoin biotin salt, edible essence and a humectant under stirring, and stirring for 10-20 min to obtain an aqueous solution;
(2) Dissolving bamboo salt and 3-O-ethyl ascorbyl ether in the rest water according to a formula, adding aluminum cloxate, glucose oxidase, lemon peel powder and sclerotium rolfsii, stirring for 10-20 min, then adding the mixture into the aqueous solution obtained in the step (1), and stirring for 10-20 min to obtain the mouthwash.
The novel mouthwash has excellent effects of sterilizing, diminishing inflammation and promoting wound healing, and can be used for preparing products for preventing and treating oral inflammatory diseases.
The aluminum cloxate and the bamboo salt in the formula are used as bactericides, and the synergistic antibacterial activity of the aluminum cloxate and the bamboo salt is better than the antibacterial activity of pathogenic bacteria causing oral inflammation, such as porphyromonas gingivalis, actinomyces viscosus and staphylococcus aureus when the aluminum cloxate and the bamboo salt are used singly. The allantoin biotin salt has the effect of promoting cell growth, and the 3-O-ethyl ascorbate ether has the effect of promoting skin mucosa tissue repair and promoting collagen biosynthesis in cells, and the allantoin biotin salt and the 3-O-ethyl ascorbate ether have the effect of promoting wound healing under the convergence effect of aluminum cloxate. The glucose oxidase can catalyze glucose to generate glucolactone and hydrogen peroxide, and has effects of preventing dental caries and whitening teeth. The interaction of the above components in the mouthwash plays remarkable roles of sterilizing, diminishing inflammation, promoting wound healing and whitening teeth, and can effectively prevent and treat various oral inflammatory diseases including oral ulcer, gingivitis, periodontitis, halitosis and the like.
The formulation of the mouthwash of the present invention is not a simple combination of any of the functional ingredients. The stability of the glucose oxidase and the allantoin biotin salt in the formula is poor, the compatibility problem exists between the glucose oxidase and the allantoin biotin salt and the bamboo salt, and the alkalinity of the bamboo salt can promote the inactivation of the glucose oxidase and the decomposition of the allantoin biotin salt. And hydrogen peroxide released by glucose oxidase in decomposing sugar in the oral cavity also reduces the enzyme activity. The inventor unexpectedly found that when a proper amount of 3-O-ethyl ascorbate ether is contained in the system, the stability of glucose oxidase and allantoin biotin salt can be improved, the oxidation resistance of the 3-O-ethyl ascorbate ether can resist the influence of hydrogen peroxide on enzyme, and the proper acidity can neutralize the alkalinity of bamboo salt, so that the decomposition of the allantoin biotin salt is inhibited, and the enzyme activity is improved. The formula is added with a small amount of lemon peel powder and sclerotium rolfsii (fiber design) TM Sensing) improves the mouth feel of the mouthwash on the one hand and the adhesion of the enzyme on the other hand, so that the enzyme can attach to teeth to continuously react.
Compared with the prior art, the invention has the following beneficial effects:
1. the mouthwash disclosed by the invention has excellent effects of sterilizing, diminishing inflammation, promoting wound healing and whitening teeth, can effectively prevent and treat various oral inflammatory diseases, and is a novel multifunctional oral care product.
2. The mouthwash disclosed by the invention is safe and nontoxic in each component, low in irritation and wide in applicable crowd.
3. The mouthwash disclosed by the invention is stable in property, comfortable in taste and easy to accept by people.
Detailed Description
The following examples are further illustrative of the invention and are not intended to be limiting thereof. The components of the formulations in the examples below, unless otherwise specified, are all conventional commercial products.
Examples 1-5 preparation of novel mouthwashes
The formulations of the novel mouthwashes of examples 1-5 of the present invention are shown in table 1 below (in mass percent):
TABLE 1 formulation composition
The preparation method comprises the following steps:
(1) Dissolving PEG-40 hydrogenated castor oil in part of water according to a formula, adding allantoin biotin salt, green tea essence and glycerol under stirring, and stirring for 15min to obtain an aqueous solution;
(2) Dissolving bamboo salt and 3-O-ethyl ascorbyl ether in the rest water according to a formula, adding aluminum cloxate, glucose oxidase, lemon peel powder and sclerotium rolfsii, stirring for 15min, then adding the mixture into the aqueous solution obtained in the step (1), and stirring for 10min to obtain the mouthwash.
Comparative example 1
Comparative example 1 differs from example 1 in that 3-O-ethyl ascorbate was not added to the formulation.
Comparative example 2
Comparative example 2 differs from example 1 in that no bamboo salt was added to the formulation.
Comparative example 3
Comparative example 3 differs from example 1 in that 3-O-ethyl ascorbate and bamboo salt were not added to the formulation.
Comparative example 4
Comparative example 4 differs from example 1 in that no aluminum cloxate was added to the formulation.
Test example one, toxicology test
The novel mouthwashes of examples 1-5 and comparative examples 1-4 were tested according to the acute oral toxicity test of the disinfection technical Specification, and evaluated for their toxic effects by the subject animal LD 50. The results show that: the acute oral toxicity test results for the mouthwashes of examples 1-5 and comparative examples 1-4 were: the LD50 is more than or equal to 5000mg/kg. Therefore, the mouthwash provided by the invention is safe, nontoxic and nonirritating, and is suitable for various people.
Test example two, antibacterial Activity and enzyme Activity detection
1. The antibacterial activity of the novel mouthwashes of examples 1 to 5 and comparative examples 1 to 4 against Porphyromonas gingivalis (ATCC 33277), actinomyces viscosus (ATCC 27044) and Staphylococcus aureus (ATCC 6538) was examined by referring to "evaluation method of antibacterial and bacteriostatic effect of QBT 2738-2012 daily chemical products", and the antibacterial rate after 60 minutes of the action was recorded, and the results are shown in Table 2.
TABLE 2 antibacterial Activity detection results
The results show that the novel mouthwash prepared in examples 1-5 has good antibacterial activity on porphyromonas gingivalis, actinomyces viscosus and staphylococcus aureus, and the effect is better than that of the mouthwash prepared in comparative examples 1-4. As is clear from comparative example 1, the formulation does not contain 3-O-ethyl ascorbyl ether and hardly affects the antibacterial activity of the mouthwash. As can be seen from comparative examples 2 and 4, the formula without bamboo salt or aluminum cloxate can obviously reduce the antibacterial activity of the mouthwash, and the antibacterial effect of the formula with single use is obviously inferior to that with simultaneous use, which indicates that the bamboo salt and the aluminum cloxate exert synergistic antibacterial effect.
2. The activity of glucose oxidase in the novel mouthwashes of examples 1-5 and comparative examples 1-4 was tested by referring to "spectrophotometry for measuring the activity of glucose oxidase of feed additive, DB 41/T1729-2018", and the mouthwashes were diluted 500 times with deionized water before measurement; the activity (U/mg) of glucose oxidase was measured at 0, 12 and 24 months, respectively, and the enzyme activity retention rate after 12 and 24 months was calculated.
After 12 months, the enzyme activity retention = (1- (0 month enzyme activity value-12 month enzyme activity value)/0 month enzyme activity value) ×100%.
After 24 months, the enzyme activity retention = (1- (0 month enzyme activity value-24 month enzyme activity value)/0 month enzyme activity value) ×100%.
The results are shown in Table 3.
TABLE 3 glucose oxidase Activity detection results
Group of | Enzyme activity retention after 12 months (%) | Enzyme activity retention after 24 months (%) |
Example 1 | 99.4 | 96.5 |
Example 2 | 99.2 | 95.8 |
Example 3 | 99.0 | 95.0 |
Example 4 | 99.6 | 97.2 |
Example 5 | 99.3 | 96.0 |
Comparative example 1 | 5.7 | / |
Comparative example 2 | 94.8 | 82.6 |
Comparative example 3 | 99.3 | 96.4 |
Comparative example 4 | 99.4 | 96.4 |
The results show that the novel mouthwashes prepared in examples 1-5 are stored for 2 years at room temperature, and the activity of glucose oxidase is reduced little, which indicates that the mouthwash system is stable and can effectively maintain the activity of glucose oxidase. As is clear from comparative example 1, the formulation does not contain 3-O-ethyl ascorbate, and the glucose oxidase activity is rapidly reduced, presumably due to rapid inactivation of glucose oxidase caused by the strong basicity of bamboo salt. As is clear from comparative example 2, the formulation does not contain bamboo salt, and the glucose oxidase activity is lowered, presumably due to slow inactivation of glucose oxidase caused by the acidity of 3-O-ethyl ascorbate. As is clear from comparative example 3, the formulation does not contain 3-O-ethyl ascorbate and bamboo salt, and hardly affects the activity of glucose oxidase. As is clear from comparative example 4, the activity of glucose oxidase was hardly affected by aluminum cloxate in the formulation. The above results indicate that the interaction of 3-O-ethyl ascorbate and bamboo salt helps to maintain glucose oxidase activity.
Test example III, evaluation of gingivitis control Effect
The random double-blind control experiment design is characterized in that 54 volunteer subjects suffering from gingivitis symptoms with different degrees are collected, 9 groups are randomly arranged, 6 persons in each group are respectively used for preparing the novel mouthwash by using the examples 1-5 and the comparative examples 1-4, and the use times are once in the morning, the evening and the evening every day, and the novel mouthwash is continuously used for 4 weeks. The gum index of volunteer subjects after 4 weeks of mouthwash use was examined using the method of oral epidemiological investigation. Gum Index (GI): checking the situation of 4 areas of gingival margin in mesial, distal, buccal and lingual areas, wherein the 4 areas are classified into 0-3 level standard and 0 point (normal gingival); score 1 (low inflammation of gums, low change in color, low edema, no bleeding in visit); 2 minutes (moderate inflammation of gum, reddish, edema, bright, bleeding visit); 3 minutes (obvious gingivitis, redness and swelling, ulceration, tendency to automatic bleeding), average. The results are shown in Table 4.
TABLE 4 evaluation results of gingivitis control Effect
The results show that the novel mouthwashes prepared in examples 1-5 are effective in treating gingivitis and have better effects than the mouthwashes prepared in comparative examples 1-4.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that the above-mentioned preferred embodiment should not be construed as limiting the invention, and the scope of the invention should be defined by the appended claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (9)
1. The novel mouthwash is characterized by comprising the following components in percentage by mass: 0.5 to 1.5 percent of aluminum cloxate, 1 to 5 percent of glucose oxidase, 1 to 3 percent of allantoin biotin salt, 4 to 8 percent of bamboo salt, 3 to 5 percent of 3-O-ethyl ascorbyl ether, 0.1 to 0.3 percent of lemon peel powder and sclerotium rolfsii, 4 to 8 percent of humectant, 0.5 to 1 percent of solubilizer, 0.1 to 0.5 percent of edible essence and the balance of deionized water.
2. The novel mouthwash according to claim 1, characterized by being composed of the following components in percentage by mass: 1% of aluminum cloxate, 4% of glucose oxidase, 2% of allantoin biotin salt, 6% of bamboo salt, 4% of 3-O-ethyl ascorbyl ether, 0.2% of lemon peel powder and sclerotium rolfskin, 6% of humectant, 1% of solubilizer, 0.5% of edible essence and the balance of deionized water.
3. The novel mouthwash according to claim 1 or 2, wherein the humectant is one or any combination of glycerin, xylitol, sorbitol.
4. A novel mouthwash according to claim 3, wherein the humectant is glycerin.
5. The novel mouthwash of claim 1 or 2, wherein the solubilizing agent is PEG-40 hydrogenated castor oil or polysorbate.
6. The novel mouthwash of claim 5, wherein the solubilizing agent is PEG-40 hydrogenated castor oil.
7. The novel mouthwash according to claim 1 or 2, wherein the edible essence is green tea essence, lemon essence, orange essence or peppermint essence.
8. A method of preparing the novel mouthwash of any of claims 1 to 7, comprising the steps of:
(1) Dissolving a solubilizer in part of water according to a formula, adding allantoin biotin salt, edible essence and a humectant under stirring, and stirring for 10-20 min to obtain an aqueous solution;
(2) Dissolving bamboo salt and 3-O-ethyl ascorbyl ether in the rest water according to a formula, adding aluminum cloxate, glucose oxidase, lemon peel powder and sclerotium rolfsii, stirring for 10-20 min, then adding the mixture into the aqueous solution obtained in the step (1), and stirring for 10-20 min to obtain the mouthwash.
9. Use of a novel mouthwash according to any of claims 1 to 7 for the preparation of a product for the prophylaxis and treatment of inflammatory diseases of the oral cavity.
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