RU2311168C2 - Composition for re-mineralization of dental tissues - Google Patents

Abstract

FIELD: stomatology.

SUBSTANCE: invention, in particular, relates to composition for re-mineralization of dental tissues in different-age persons. Composition prepared in the form of gel contains sorbitol, hydroxyethyl cellulose, polysorbate, odorant, methylparben, calcium glycerophosphate, magnesium chloride, xylitol, guar gum, and water, all components in specified proportions.

EFFECT: enhanced re-mineralization effect for prevention of caries, treatment of non-caries affections, and for improvement of color and brightness of teeth.

2 cl, 2 tbl, 3 ex

Description

The invention relates to dentistry and perfume industry, and specifically to a composition for remineralization of tooth tissues.

Known intended for the remineralization of dental tissue composition containing calcium gluconate, sodium carboxymethyl cellulose, dimexide, furatsilin, glycerin and water (SU A3 No. 1774870, IPC 5 A61K 6 / 02.1992).

The prepared composition is dried and used in the form of an elastic film for application on the affected areas of the teeth, the surfaces of which are previously cleaned of plaque. The applied film is moistened with saliva, converted to gel and gradually absorbed over a period of 60-120 minutes, which ensures a prolonged release of remineralizing substance and lengthening the time of its exposure to hard tooth tissues. The need for film overlay, the duration of resorption make it difficult to use the known composition in the home directly by the patient.

The technical result of the invention lies in the practical implementation of an effective remineralizing composition that uses the available components, which can be used by the patient independently, without any help for caries prevention, treatment of non-carious lesions, including dental hyperesthesia, and improvement of the appearance (color and gloss) of teeth .

The achievement of this technical result is provided by a composition for remineralization of tooth tissues, which contains glycerin, hydroxyethyl cellulose, sorbitol, polysorbate, methyl paraben, perfume, calcium glycerophosphate, magnesium chloride, xylitol, guar gum and water.

The components are taken in the following ratio, wt.%:

glycerol 8-15 sorbitol 8-15 xylitol 8-18 hydroxyethyl cellulose 1.5-2.8 polysorbate 0.6-1.2 perfume 0.3-0.6 methyl paraben 0.2-0.3 calcium glycerophosphate 0.7-1.9 magnesium chloride 0.06-0.20 guar gum 0.06-0.15 perfume 0.3-0.6 drinking water rest

The composition, as a rule, is prepared in the form of a gel.

Xylitol as part of the product performs several functions: as a sweetener, xylitol improves its taste characteristics; Being a polyhydric alcohol, it performs the function of a water-retaining component. The mechanism of involvement of this substance in the biochemical metabolism of streptococci is characterized as lethal synthesis, in connection with which the activity of pathogenic microorganisms decreases and the condition of the organs of the oral cavity improves. Xylitol promotes the transition of biologically active components of the composition into tooth tissue (Tanzer JM / Xylitol chewing gum and dental caries. // Int Dent J. 1995 Feb; 45 (1 Suppl 1): 65-76).

Calcium glycerophosphate is a source of active intake of phosphorus and calcium in teeth and periodontal tissues and contributes to the improvement of the physiological mineralization process in the enamel / saliva system. Provides anti-carious effect of the composition, as well as remineralization for non-carious tooth damage. In addition, it enhances the anabolic processes in the tissues, which is important for the prevention of dental diseases.

Magnesium is a structural component of teeth. Magnesium is introduced into the complex as a microelement, which is a cofactor for phosphatases. Under the influence of these enzymes, the inclusion of phosphates in the hard tissues of the teeth increases.

To increase the stability of the film containing mineral additives formed on the teeth, as well as to increase the adhesion of this film to hard tissues, a guar gum is additionally introduced into the composition. Guar gum powder is made from the endosperm of the seeds of Cyamopsis tetraganoloba, a plant known as guar. By its chemical structure, guar gum is a nonionic polysaccharide of plant origin. The molecular structure is a direct chain formed by galactose and mannose, therefore, the guar gum is galactomannan, the ratio of mannose to galactose is approximately 2: 1. When dissolved in cold or hot water, guar gum forms a highly viscous gel (Industrial Gums. Third edition: edited by Whistler R. L. and BeMiller J.N .; Academic Press 1993).

Consequently, a highly effective gel composition has been created that is applied after cleansing of soft plaque daily, in courses of 2-4 weeks, depending on the clinical situation in the oral cavity, for caries prophylaxis, treatment of non-carious lesions, including dental hyperesthesia and improvement of external type (color and gloss) of teeth.

The possibility of carrying out the invention is confirmed by examples of specific compositions, the ratio of the components of which are presented in table 1.

The compositions are prepared as follows.

The required amount of water is heated in a measuring meter to 75-80 ° С, then the heated water is loaded into the mixer, methyl paraben, magnesium chloride, xylitol, sorbitol are added. The mixture is stirred until a clear solution is formed for 20 minutes.

Table 1 Components Concentration, wt.% Composition 1 Composition 2 Composition 3 Glycerol 8 10 fifteen Sorbitol fifteen 10 8 Xylitol 8 fourteen eighteen Methylparaben 0.2 0.24 0.3 Guar gum 0.06 0.10 0.15 Hydroxyethyl cellulose 2,8 2.2 1,5 Perfume 0.3 0.4 0.5 Calcium Glycerophosphate 0.7 1.2 1.9 Magnesium chloride 0.06 0.12 0.2 Polysorbate 0.6 0.9 1,2 Drinking water Up to 100% Up to 100% Up to 100%

The aqueous solution of the components is cooled to 50-55 ° C, a suspension is added to it and stirred until a homogeneous mass is formed for 30 minutes.

Polysorbate is separately heated to 45-50 ° C, perfume is added and mixed until a homogeneous mixture is formed for 10 minutes.

This mixture is added to the mass obtained above and mixed until a homogeneous gel is obtained for 20-30 minutes.

The resulting gel is cooled with stirring to a temperature of 20-25 ° C and Packed in tubes of polymer material.

The method of preparation and the sequence of administration for all examples of the composition is the same.

The technique of application.

Applications can be done in two ways:

- using standard mouthguards;

- without the use of mouthguards, with the use of cotton rolls or without them.

For intensive mineralization (with acute caries, treatment of erosion and other non-carious lesions of the teeth), the gel is applied to the teeth with an even thin layer with a brush or in another way, and then covered with a mouthguard. The duration of the application is 12-15 minutes, then the excess gel is spit out. After the application, you should not eat or drink, or rinse your mouth for one hour. Thanks to this, a prolonged effect is achieved.

The application of the composition to the teeth without the use of mouthguards is carried out as follows: the soft tissues of the cheeks, lips and tongue are isolated by rollers, the composition is applied to the teeth with a thin uniform layer for 7-12 minutes. After the procedure, the insulating rollers and excess gel spit. Eating, drinking and rinsing the oral cavity is recommended no earlier than after one hour.

Examples of the use of the composition for its intended purpose.

Example 1

Patient K., 38 years old, complained of hyperesthesia and unsatisfactory cosmetic appearance of the teeth.

At the first inspection on 4.04.2005. found:

IG (hygiene index) - 1.95 points,

IRGZ - 54%,

IIHZ - 2.8 points.

The color of the teeth on the Vita scale is C3, the gloss is not sufficient.

The patient was prescribed the use of the composition for applications for a 4-week course using insulating rollers.

Re-examination after 4 weeks 05/05/2005. There are no complaints.

Objective indicators:

IG (hygiene index) - 1.57 points,

IRGZ - 6.2%,

IIGZ - 0.

The color of the teeth according to the Vita - C1 scale, the gloss of teeth has become more intense.

Example 2

Patient K., 28 years old, turned on 9.06.2005 with complaints of hyperesthesia of the teeth, partial lack of gloss and unsatisfactory tooth color.

Objective data:

IG (hygiene index) - 2.17 points,

IRGZ - 62.5%,

IIHZ - 2.1 points.

The color of the teeth was not determined, but the prevalence of yellow tones over white was noted.

It is recommended to carry out applications with the composition daily for 3 weeks using standard mouthguards. Re-examination after 3 weeks on July 8, 2005.

There are no complaints, the patient notes a slight reaction to very cold food (ice cream).

Objective indicators:

IG (hygiene index) - 1.5 points,

IRGZ - 9.3%,

IIHP - 1.1 points.

Teeth color - visually noticeable lightening, a pronounced brilliance of teeth appeared, which satisfied the patient.

Example 3

Patient M., 36 years old, complained of hyperesthesia after a course of home whitening. At the first inspection on 2.08.2005 it was established:

The color of the teeth on the Vita scale is C2, the gloss is not sufficient.

IG - 1.9 points

IIHZ - 2.1 points,

IRGZ - 62.5%.

It is recommended to carry out applications with the composition daily for 4 weeks using standard mouthguards. Re-examination after 4 weeks 08/31/2005. There are no complaints.

The color of the teeth on the Vita - A1 scale, the gloss of the teeth has become more intense.

IIGZ, IRGZ - 0,

IG - 1.2 points.

The summarized results of monitoring the action of the remineralizing gel were compared with the data obtained using fluorinated toothpastes and gels, which are most often used for these purposes in modern practice.

The main group (remineralizing gel).

Matching group (fluoride-containing toothpastes and gels).

The comparison results are presented in table 2.

table 2 Suggested composition Fluoride formulations (commercial samples) source after 4 weeks source after 4 weeks Hygiene Index (points) 2.12 ± 0.13 1.5 ± 0.12 2.30 ± 0.21 1.79 ± 0.18 The prevalence index of hyperesthesia of the teeth (IHRH),% 39.5 ± 3.3 9.3 ± 0.6 33.0 ± 1.9 19.3 ± 0.9 Intensity index of dental hyperesthesia (IIHP, points) 21.0 ± 0.9 1.01 ± 0.05 2.3 ± 0.7 1.61 ± 0.8

In addition, 89.7% of the observed individuals noted a significant improvement in color (teeth became whiter) and gloss of enamel, which also indicates an active remineralizing effect of the composition.

Claims (2)

1. The composition for remineralization of tooth tissues containing glycerin, carboxymethyl cellulose, water, characterized in that it further comprises sorbitol, polysorbate, methyl paraben, perfume, calcium glycerophosphate, magnesium chloride, xylitol and guar gum, while hydroxyethyl is used as carboxymethyl cellulose, the following ratio of components, wt.%: glycerol 8-15 sorbitol 8-15 xylitol 8-18 hydroxyethyl cellulose 1.5-2.8 polysorbate 0.6-1.2 methyl paraben 0.2-0.3 calcium glycerophosphate 0.7-1.9 magnesium chloride 0.06-0.20 guar gum 0.06-0.15 perfume 0.3-0.6 drinking water up to 100 2. The composition according to claim 1, characterized in that it is made in the form of a gel.