JPH11279023A - Composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antiseptic means for a composition used for external use and having remarkably excellent safety and usability. SOLUTION: This composition for external use, such as a cosmetic, contains as an antiseptic means, a combination of 2-phenoxyethanol generally used as an antiseptic auxiliary with 2-methyl-1,3-propanediol generally having been used as a humectant. Even when the 2-phenoxyethanol is compounded in a small amount, an excellent antiseptic effect can be recognized on the composition for the external use.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external composition. In particular, with excellent antiseptic properties,
The present invention relates to an external composition having significantly improved usability and safety.

[0002]

2. Description of the Related Art Generally, in external compositions such as cosmetics, it is necessary to suppress the growth of microorganisms contaminating from the outside and to kill these microorganisms with the lapse of time to improve the shelf life of products. For the purpose, a preservative such as paraoxybenzoate (commonly called parabens) and a preservative auxiliary such as phenoxyethanol are blended. Such preservatives such as parabens and preservative aids such as phenoxyethanol are excellent in safety and effectiveness as preservative means used in an external composition. However, it is not unforeseen that a very small number of sensitive users may have a feeling of irritation during use. In recent years, in particular, there has been a tendency for more externally-friendly compositions to be applied to the skin. I can't deny the difficulties. Of course, it is also possible to create a preservative such as parabens or an external composition that does not contain a preservative aid such as phenoxyethanol. The necessity of making full use of complicated means is pressed, and the tendency of lack of economy, versatility, etc. is increased.

[0003]

The problem to be solved by the present invention is to provide a means for preserving an external composition which is extremely excellent in safety and usability.

[0004]

Means for Solving the Problems The present inventor has made intensive studies to solve the above-mentioned problems. As a result, as described above, 2-phenoxyethanol, which is widely used as a preservative, and 2-methyl-1,3-propanediol, which has been conventionally used as a humectant, are combined and blended as a preservative. As a result, even when the blending amount of 2-phenoxyethanol was small, an excellent antiseptic effect was recognized in the composition for external use, and it was found that the above-mentioned problem could be solved thereby, thereby completing the present invention.

[0005] That is, the present invention provides two preservative means.
It is intended to provide a composition for external use, such as cosmetics, containing -methyl-1,3-propanediol and 2-phenoxyethanol. Note that, in the present invention, the `` external composition '' is a concept that generally encompasses all the compositions used for external use, for example, basic cosmetics, makeup cosmetics, cosmetics such as hair cosmetics, and ointments and the like. It refers to a composition widely applicable to various pharmaceuticals or quasi-drugs. The present invention also separately provides the external composition of these embodiments. In the present invention, "preservation" means resistance to all contaminating microorganisms such as bacteria, molds, yeasts, and the like, and "preservation power" means protection against all these contaminating microorganisms. .

[0006]

Embodiments of the present invention will be described below. 2-Methyl-1,3-propanediol, which is blended into the external composition according to the present invention (hereinafter referred to as the external composition of the present invention) as one element of preservative means, is usually used as one of moisturizing components. The components incorporated therein, which are usually produced by a known method, can be incorporated into the composition for external use of the present invention. In addition, a commercially available product (eg, a product of TEGUSSA) can be blended in the composition for external use of the present invention.

In the composition for external use of the present invention, 2-methyl-
The amount of 1,3-propanediol should be 0.1% by weight or more based on the total amount of the composition in order for the desired preservative effect to be effectively exhibited sufficiently in the composition for external use. And more preferably 1.0% by weight or more. It is particularly preferable to mix the composition in an amount of 3.0% by weight or more with respect to the total amount of the composition since the preservative effect is remarkably improved.

In the composition for external use of the present invention, 2-methyl-
The upper limit of the amount of the 1,3-propanediol to be added is not particularly limited, but is usually 2 to the total amount of the composition.
It is blended in a proportion of 0.0% by weight or less. 20. of the composition
If the content is more than 0% by weight, the external use composition of the present invention tends to deteriorate in usability, such as accompanied by a sticky feeling of use, which is not preferable.

2-Phenoxyethanol, which is incorporated in the composition for external use of the present invention together with the above-mentioned 2-methyl-1,3-propanediol as another element of the preservative means, is a compound having a structure represented by the following formula. .

Embedded image

This 2-phenoxyethanol has a boiling point of 237 ° C., 165 ° C./80 mm and an optical rotation of d221.10.
2, n20D 1.534 liquid, which is a component usually incorporated in an external composition as a preservative.

The composition for external use of the present invention contains 2-phenoxyethanol produced by a generally known method, for example, a method of reacting phenol with ethylene oxide or reacting sodium phenoxide with ethylene chlorohydrin. It is of course possible to mix commercially available products.

The amount of 2-phenoxyethanol in the composition for external use of the present invention depends on the strength of the preservative to be imparted,
The above 2-methyl-1,3 compounded in combination with this
-Can be appropriately determined according to the amount of propanediol, and is not particularly limited, but 0.01% by weight based on the total amount of the composition in order to effectively exhibit a desired preservative effect. It is preferable to mix at the above ratio.

The upper limit of the amount of 2-phenoxyethanol in the composition for external use of the present invention is not particularly limited, but the major feature of the composition for external use of the present invention is that the amount of 2-phenoxyethanol can be reduced. Since there is only one, the amount of the 2-phenoxyethanol is preferably as small as possible as long as the desired effect of the present invention is not impaired.

The above-mentioned 2-methyl-1,3-propanediol and 2
-The mixing ratio with phenoxyethanol is generally such that, when one compounding amount is set large, the other compounding amount is relatively small, and conversely, when one compounding amount is set small, the other compounding amount is relatively small. It is preferable to set the amount to a large amount in order to effectively exhibit the desired effect of the present invention.

For example, as shown in an embodiment described later, 2
When the blending amount of -methyl-1,3-propanediol is 1.0% by weight or less (excluding 0% by weight) based on the total amount of the composition, 2-phenoxyethanol is blended at 0.3% by weight or more. The effect can be exhibited relatively well. Also,
When the amount of 2-methyl-1,3-propanediol is more than 1.0% by weight and not more than 3.0% by weight based on the total amount of the composition, 2-phenoxyethanol is added at 0.1% by weight. The effect can be relatively favorably exhibited by the above-mentioned mixing.
When the amount of 2-methyl-1,3-propanediol is more than 3.0% by weight and not more than 5.0% by weight based on the total amount of the composition, 2-phenoxyethanol is added in the same amount as 0.05%. If it is blended in an amount of not less than weight%, the effect can be exhibited relatively well. Further, when the blending amount of 2-methyl-1,3-propanediol exceeds 5.0% by weight and 10.0% by weight or less based on the total amount of the composition, 2-phenoxyethanol is added to the composition at 0.01% by weight. If it is blended in an amount of not less than weight%, the effect can be exhibited relatively well.

In this way, the combination of 2-methyl-1,3-propanediol and 2-phenoxyethanol results in a surprisingly small amount of 2-methyl-1,3-propanediol.
By blending phenoxyethanol, an antiseptic composition having sufficient preservative properties and having excellent usability and safety is provided.

In the present invention, other preservatives and preservatives need not be added to the composition for external use of the present invention, as long as only the intended effects of the present invention are intended. The addition of other preservatives or preservatives usually used in the composition for external use to the external composition of the present invention is not prevented as long as the intended effect is not impaired.

In addition, as long as the desired effects of the present invention are not impaired, the components usually contained in the external preparations, such as humectants, ultraviolet ray protective agents, vitamins, etc., depending on the properties of the intended external composition. , An anti-inflammatory agent, a whitening agent, a vasodilator, an astringent, a cooling agent, a hormonal agent, and the like.

As described above, the composition for external use of the present invention can be widely applied to cosmetics, pharmaceuticals, quasi-drugs, etc. applied to the outer skin, and the dosage form is aqueous, water-based, Solubilizing, emulsifying, oil-liquid, gel, paste,
Ointment system, aerosol system, water-oil two-layer system, water-oil-powder 3
A wide range of dosage forms such as a layer system can be adopted. That is, basic cosmetics can be widely applied to the above-mentioned various dosage forms in the form of facial cleanser, lotion, milky lotion, cream, gel, essence (cosmetic), pack mask and the like. Furthermore, makeup cosmetics can be widely applied to the above-mentioned various dosage forms in the form of foundation, mascara, nail enamel, lipstick and the like. In addition, hair cosmetics can be widely applied to various forms such as shampoos, rinses, and hair nourishes. As long as it is a drug or a quasi drug, it can be widely applied to various ointments and the like. In addition, the dosage form and form which the composition for external use of this invention can take are not limited to these dosage forms and forms.

In the composition for external use of the present invention, commonly known base components are blended widely according to the desired dosage form and form as long as the desired effects of the present invention are not impaired by their blending. can do. That is, liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicones, various surfactants, sequestering agents, water-soluble polymers, thickeners,
Various powder components, coloring agents, fragrances, water, and the like can be appropriately compounded in the composition for external use of the present invention as needed. The specific formulation of the composition for external use of the present invention will be described in Examples described later.

[0021]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but it should be understood that the technical scope of the present invention is not limited to these Examples. In this example, "% by weight" or "%" indicating the blending amount means% by weight based on the total amount of the composition unless otherwise specified. Prior to disclosing the examples, a use test and a test for judging preservative power will be described first.

Use test The composition for external use of the present invention was used for one week at a frequency of twice in the morning and evening per day for 30 panelists who complained of skin irritation when using an external composition containing paraben in the past. Then, the user was required to report the satisfaction of the use and the presence or absence of skin irritation.

After the inoculation of the bacterial solution to 30 ml of the test sample for judging the preservative power , the change in the number of bacteria was examined by a smear method. The inoculated bacteria were evaluated for their antiseptic activity based on changes in the number of bacteria up to two weeks after the use of mold, yeast, and bacteria, and the obtained results were classified into the following four-grade criteria. In addition, among the following classifications, those with ◎ or ○ were judged to be acceptable.

A: The effect is immediately recognized. ：: The effect is gradually recognized. Δ: Almost no effect was observed. X: No effect is observed at all.

[Examples 1 and 2] The above-mentioned use test and antiseptic judgment test were carried out on a lotion as an embodiment of the composition for external use of the present invention having the formulation shown in Table 1 below and a comparative example thereof. Described. In addition, these lotion production methods followed a method generally used as a lotion production method.

[0026]

[Table 1]

In Examples 1 and 2, skin irritation was low, the proportion of those satisfied with the usability was high, and the antiseptic property was ensured.

In Comparative Examples 1 and 2 in which 2-phenoxyethanol was not added, when the amount of 2-methyl-1,3-propanediol was small, skin irritation was small,
Although the proportion of those who were satisfied with the usability was also large, the preservative power was poor. On the other hand, when the amount of 2-methyl-1,3-propanediol was large, few people were satisfied with the usability, although the preservative power was excellent. Furthermore, 2-methyl-1,
In Comparative Example 3 in which 3-propanediol was not blended, skin irritation was small and the proportion of those satisfied with the usability was also large, but the antiseptic power was poor. From these results, it is evident that a combination of 2-methyl-1,3-propanediol and 2-phenoxyethanol provides an externally-applied composition that maintains preservative power, has less skin irritation, and has good usability. Became.

Examples 3 to 11 Further, 2-methyl-
A lotion with the blending amounts of 1,3-propanediol and 2-phenoxyethanol changed [the blending components other than the blending amounts of 2-methyl-1,3-propanediol and 2-phenoxyethanol are shown in Table 1 above. The same antiseptic test and use test (only for usability) were carried out.

Each of the lotions is 2-methyl-1,3-
Table 2 shows the amounts of propanediol and 2-phenoxyethanol and the test results.

[Table 2]

In Table 2, in the composition for external use of the present invention, 2-methyl-1,3-propanediol and 2
-It became clear that not only the amount of phenoxyethanol but also the ratio of the two had a great effect on the intended effect of the present invention. That is, 2-methyl-1,3-
In Examples 3 and 4 in which both the amounts of propanediol are 1.0% by weight, the preservative power is not sufficient when the amount of 2-phenoxyethanol is 0.1% by weight (Example 3). At 0.3% by weight (Example 4) satisfactory results were obtained.

In Examples 5 and 6 in which the content of 2-methyl-1,3-propanediol was 3.0% by weight, the content of 2-phenoxyethanol was 0.0%.
At 5% by weight (Example 5) the preservative power is not sufficient, but at 0.1% by weight (Example 6) satisfactory results were obtained. In addition, in Example 7 in which both the amounts of 2-methyl-1,3-propanediol were 5.0% by weight, satisfactory results were obtained when the amount of 2-phenoxyethanol was 0.05% by weight. Was.

In Examples 8 and 9 in which the content of 2-methyl-1,3-propanediol was 10.0% by weight of the composition for external use, the content of 2-phenoxyethanol was 0.01% by weight. % (Example 8) and 0.05% by weight (Example 9) were not sufficiently usable, but satisfactory results were obtained in the preservative power. Furthermore, in Example 10 in which the blending amount of 2-methyl-1,3-propanediol was 20.0% by weight, even when the blending amount of 2-phenoxyethanol was 0.01% by weight, excellent antiseptic power was obtained. However, the evaluation of the usability was confirmed in a large amount of 2-methyl-
It decreased due to stickiness due to 1,3-propanediol.

This tendency can be seen in Example 11 in which the blending amount of 2-methyl-1,3-propanediol is 25.0% by weight.
Remarkably appeared. That is, even when the blending amount of 2-phenoxyethanol was 0.01% by weight, the lotion of Example 11 exhibited extremely excellent antiseptic power, but its usability was extremely poor. In addition, Comparative Examples 4-6 which did not mix 2-phenoxyethanol at all did not have sufficient usability or antiseptic power.

According to the results, the mixing ratio of 2-methyl-1,3-propanediol and 2-phenoxyethanol in the composition for external use of the present invention was 2-methyl-1,3.
-When the blending amount of propanediol is 1.0% by weight or less (excluding 0% by weight), it is apparent that relatively good results can be obtained by blending 2-phenoxyethanol at 0.3% by weight or more. became. Also, 2-methyl-1,3
-When the amount of propanediol is more than 1.0% by weight and not more than 3.0% by weight, it is clear that relatively good results can be obtained by adding 0.1% by weight or more of 2-phenoxyethanol. Became. Furthermore, 2-methyl-
When the amount of 1,3-propanediol is more than 3.0% by weight and not more than 5.0% by weight, relatively good results can be obtained by adding 0.05% by weight or more of 2-phenoxyethanol. It became clear. Moreover, 2
The amount of -methyl-1,3-propanediol is 5.0.
In the case of more than 10.0% by weight and more than 2% by weight, when 0.01% by weight or more of 2-phenoxyethanol is blended,
It has been found that relatively good results can be obtained.

Hereinafter, the compositions for external use of the present invention having various formulations will be exemplified. In all of the examples, the skin preservation power was excellent, the skin irritation was small, and the usability was good. In addition,
The method for producing the external composition in these examples was in accordance with a method generally used as a method for producing the external composition in each embodiment.

[Example 12] Astringent lotion% by weight 2-methyl-1,3-propanediol 0.1 2-phenoxyethanol 0.3 Polyoxyethylene (POE = 50) oleyl ether 0.5 Polyethylene glycol 300 1.0 Ethyl alcohol 18.0 Dipropylene glycol 3.0 Lactic acid 0.02 50% by weight aqueous solution of sodium lactate 0.25 Trisodium edetate 0.01 Purified water balance

Example 13 Cleansing Foam Weight% Stearic Acid 8.0 Palmitic Acid 6.0 Myristic Acid 6.0 Lauric Acid 4.0 Potassium Hydroxide 5.2 Glyceryl Monostearate 2.0 Beeswax 1.5 2-Methyl-1,3-propanediol 20.0 2-phenoxyethanol 0.01 Polyethylene glycol 1500 5.0 Glycerin 10.0 Purified water balance

Example 14 Emollient Emulsion Weight% 2-methyl-1,3-propanediol 5.0 2-phenoxyethanol 0.1 cetanol 1.5 stearyl alcohol 1.8 petrolatum 2.0 dimethylpolysiloxane (20cs) 1.5 Squalane 2.5 Isopropyl myristate 2.5 Glyceryl monostearate 1.8 Polyoxyethylene (POE = 5) Glyceryl monostearate 1.8 Polyoxyethylene (POE = 20) Cetyl ether 1.5 Carboxyvinyl Polymer 0.25 Potassium hydroxide 0.05 L-arginine 0.2 Glycerin 4.0 Dipropylene glycol 2.0 Trisodium edetate 0.02 Purified water balance

Example 14 Skin Treatment Gel Weight% 2-Methyl-1,3-propanediol 10.0 2-Phenoxyethanol 0.05 Dimethylpolysiloxane (6cs) 0.5 Isopropyl myristate 1.5 Polyoxyethylene (POE = 60) hydrogenated castor oil 0.5 tocopherol acetate 0.2 monoammonium glycyrrhizinate 0.05 carboxyvinylpyrimer 0.45 potassium hydroxide 0.15 glycerin 16.0 dipropylene glycol 2.0 trisodium edetate 0.01 Purified water balance

[0041]

Industrial Applicability According to the present invention, there is provided a preservative means for an external composition which is extremely excellent in safety and usability.

Claims (2)

[Claims] An external composition containing 2-methyl-1,3-propanediol and 2-phenoxyethanol as preservatives. 2. The external composition according to claim 1, wherein the external composition is a cosmetic.