JPH0853338A - Dermal agent for external use - Google Patents

Abstract

PURPOSE:To obtain dermal agent for external use remarkably improved in its security while keeping enough preservability. CONSTITUTION:This external agent for external use is added with >=0.1wt.%, especially >=3wt.% of (A) hexylene glycol and 0.01wt.%, especially >=0.2wt.% of (B) phenoxy ethanol. When A is <1wt.%, B is >=0.3wt.%; when A is >=1wt.% and <3wt.%, B is >=0.1wt.%; when A is >=3wt.% and <10wt.%, B is >=0.05wt.%; when A is >=10wt.%, B is >=0.01wt.%. As an ingredient usually added to this dermal agent for external use, a moisture keeping agent, an emollient ingredient, a surfactant, a thickener, a sequestering agent and other agents, a pigment, an essence, etc., can be used together, as necessary.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which is remarkably improved in usability and safety while ensuring sufficient antiseptic property.

[0002]

2. Description of the Related Art In recent years, there has been a demand for a safe external preparation for skin which is gentle on the skin. On the other hand, external preparations for the skin must also give consideration to preservability, and it is necessary to consider antiseptic and fungicide.Many external preparations for the skin contain paraoxybenzoic acid ester, commonly known as parabens, as an antiseptic agent. It is the actual situation that secures.

However, when parabens are mixed as a preservative, some sensitive users rarely experience skin irritation such as bleeding during use, and the usability is unsatisfactory. It is naturally possible to prepare an external preparation for skin without blending parabens, but in that case, in order to ensure antiseptic properties, use a subdivision container for each usage or a tubeless backless container. Other complicated means such as the provision of a mechanism are required, which lacks versatility.

[0004]

DISCLOSURE OF INVENTION Problems to be Solved by the Invention As a result of intensive research conducted by the present inventors in view of such circumstances, a skin external preparation satisfying both usability and safety while ensuring antiseptic properties by blending phenoxyethanol together with hexylene glycol. The present invention has been completed and the present invention has been completed.

[0005]

Means for Solving the Problems That is, the gist of the present invention resides in a skin external preparation characterized by containing phenoxyethanol together with hexylene glycol.

The structure of the present invention will be described in detail below. The hexylene glycol used in the present invention is 2-Methyl-2,4-pentanedi represented by Chemical Formula 1.
ol.

[0007]

Embedded image

The blending amount of hexylene glycol in the present invention is not particularly limited, but considering the antiseptic property as an external preparation for skin, it is required to be 0.1% by weight (hereinafter referred to as%) or more, which is preferable. Is 1% or more. It is more preferable to see the remarkable effect of the present invention when the content is 3% or more. It is difficult to specifically limit the upper limit of the blending because of the property as an external preparation for skin, but when it is blended in a remarkably excessive amount, the usability such as stickiness is deteriorated, so that the blending ratio is preferably 20% or less.

The phenoxyethanol used in combination with hexylene glycol in the present invention is 2-Phenoxyethanol, which is represented by Chemical formula 2.

[0010]

Embedded image C ₆ H ₆ —O—CH ₂ —CH ₂ —OH

The blending amount of phenoxyethanol which exerts the effect of the present invention is required to be 0.01% or more, and the blending amount is determined according to the desired antiseptic property. Preferably 0.
It is at least 05%, more preferably at least 0.2%. Although the effect of the present invention is not hindered even if it is excessively compounded, a sufficient effect can be obtained with a compounding amount of 1% or less,
No further formulation is necessary.

As an example of the optimum blending ratio of hexylene glycol and phenoxyethanol, when the amount of hexylene glycol is less than 1%, the amount of phenoxyethanol is 0.3% or more, and when the amount of hexylene glycol is 1% or more and less than 3%. Contains 0.1% or more of phenoxyethanol,
When the amount of hexylene glycol is 3% or more and less than 10%, the amount of phenoxyethanol is 0.05% or more, and when the amount of hexylene glycol is 10% or more, the amount of phenoxyethanol is 0.01% or more.

In the present invention, as a skin external preparation base containing hexylene glycol and phenoxyethanol, any conventional skin external preparation base can be used. That is, liquids, gels, pastes, creams and the like can be used, and as a component that is usually blended in a skin external preparation, a moisturizer, an emollient component, a surfactant, a thickener, a sequestering agent, and the like. It goes without saying that drugs, dyes, fragrances, etc. can be used in combination.

[0014]

EXAMPLES The present invention will now be described in more detail with reference to more examples, but the present invention is not limited thereto.

[Use Test and Antiseptic Test] Lotions having the formulations shown in Table 1 were prepared, and a use test and an antiseptic test were carried out.

<Testing Method for Use> 30 panelists who complained of skin irritation when using a paraben-containing skin external preparation in the past were allowed to use it under normal use conditions for 1 week to check the satisfaction of usability and the presence or absence of skin irritation. I had it declared.

<Test method for determining antisepticity> After inoculating a bacterial solution to a test amount of 30 ml of Examples and Comparative Examples, changes in the number of bacteria were examined by a smearing method. The inoculum is mold (10 ⁴ cfu (colony forming
unit) / g), yeast (10 ⁴ cfu / g), bacteria (10 ⁶ cfu)
fu / g) was used to evaluate the antibacterial activity by the change in the number of bacteria until the lapse of 2 weeks, and the obtained effects were classified according to the following four-stage criteria. ◎; Within one week, all molds, yeasts and bacteria are 10
Reduced to 0 cfu / g or less ○; Within 2 weeks, all of mold, yeast and bacteria are 10
Reduced to 0 cfu / g or less. △: After 2 weeks, any of mold, yeast and bacteria
100 cfu / g or more remained ×; mold, yeast and bacteria all had 100 c even after 2 weeks
FU / g or more remained The antiseptic properties of the external preparation for skin were evaluated as ◎ or ○ to pass. Table 1 shows the results of the use test and the antiseptic test.
Described in.

[0018]

[Table 1] ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Example 1 Example 2 Comparative example 1 Comparative example Example 2 ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Hexylene glycol 5 (%) 3 (%) 3 (%) 3 (%) Phenoxyethanol 0.2 0.2 ── ── Methylparaben ── ── 0.2 ── Ethyl alcohol 2 2 2 2 Glycerin 1 1 1 1 POE (60) Hydrogenated castor oil 0.4 0.4 0.4 0.4 Citric acid 0.03 0.03 0.03 0.03 Trisodium citrate 0.07 0.07 0.07 0.07 Trisodium edetate 0.02 0.02 0.02 0.02 Purified water Remainder Remainder Remainder Remainder ━━━━━━━━━━━━━━━━━━━━━━━━━━━━ ━━━━━━━━ Usage test results (those who complain of skin irritation) 0/30 0/30 12/30 0/30 (those who are satisfied with usability) 29/30 28/30 16/30 28 / 30 Antiseptic test results ◎ ○ ◎ × ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

In Examples 1 and 2, the skin irritation was less than in Comparative Example 1 and the proportion of those who were satisfied with the usability was high and the antiseptic property was secured, which is an effect according to the present invention. Further, in Comparative Example 2, the proportion of those who are less irritated to the skin and who are satisfied with the usability is high, but the antiseptic properties are poor.

[Example 3] Astringent lotion (%) Hexylene glycol 0.1 Phenoxyethanol 0.5 POE (50) oleyl ether 0.5 PEG300 1 Ethyl alcohol 18 Dipropylene glycol 3 Lactic acid 0.02 Sodium lactate 50% liquid 0.25 Trisodium edetate 0.01 Purified water balance

Example 4 Cleansing Foam (%) Stearic Acid 8 Palmitic Acid 6 Myristic Acid 6 Lauric Acid 4 Caustic Potassium 5.2 Glyceryl Monostearate 2 Beeswax 1.5 Hexylene Glycol 20 Phenoxyethanol 0.01 PEG 1500 5 Glycerin 10 Purified water balance

Example 5 Emollient Emulsion (%) Hexylene glycol 5 Phenoxyethanol 0.1 Cetanol 1.5 Stearyl alcohol 1.8 Vaseline 2 Dimethylpolysiloxane (6cs) 1.5 Squalane 2.5 Isopropyl myristate 2. 5 Glyceryl monostearate 1.8 POE (5) Glyceryl monostearate 1.8 POE (20) cetyl ether 1.5 Carboxy vinyl polymer (Carbopol 940) 0.25 Caustic soda 0.05 L-Arginine 0.2 Glycerin 4 Dipropylene glycol 2 Trisodium edetate 0.02 Purified water balance

Example 6 Skin Treatment Gel (%) Hexylene Glycol 10 Phenoxyethanol 0.05 Dimethylpolysiloxane (6cs) 0.5 Isopropylmyristate 1.5 POE (60) Hardened Castor Oil 0.5 Tocopherol Acetate 0 .2 monoammonium glycyrrhizinate 0.05 carboxyvinyl polymer (Hibiswako 105) 0.45 caustic soda 0.15 glycerin 16 dipropylene glycol 2 trisodium edetate 0.01 purified water balance

Example 7 Powdery Foundation (%) Talc 20.3 Mica 35.0 Kaolin 5.0 Titanium dioxide 10.0 Mica titanium 3.0 3.0 Zinc stearate 2.0 Yellow iron oxide 3.0 Black iron oxide 0.2 Nylon powder 10.0 Squalane 6.0 Lanolin acetate 2.0 Octyldodecyl myristate 3.0 Sorbitan monooleate 0.5 Hexylene glycol 2.0 Phenoxyethanol 0.1

The external preparations for skin of Examples 3 to 7 all had sufficient antiseptic properties under normal use conditions and were excellent in usability and safety.

[0026]

INDUSTRIAL APPLICABILITY In the external preparation for skin of the present invention, by incorporating phenoxyethanol together with hexylene glycol, it is possible to remarkably improve usability and safety while ensuring antiseptic property.

Claims (1)

[Claims] 1. An external preparation for skin, characterized by containing hexylene glycol and phenoxyethanol.