JP2000186009A - Antisepticity auxiliary and low-irritant cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antisepticity auxiliary comprising raffinose and capable of giving low-irritant cosmetics reduced in the amount of antiseptic formulated therein. SOLUTION: This antisepticity auxiliary is obtained by including raffinose which is a kind of trisaccharide as a substance having the structure of O-α-D- galactopyranosyl-(1,6-)-O-α-D-glucopyranosyl-(1,2)-β-D-fructofuranoside, and is afforded from eucalyptus manna, sugar beet molasses, cottonseed, or the like (pref. from sugar beet molasses). The low-irritant cosmetic is obtained by including pref. 0.1-20 wt.% of the above auxiliary and another antiseptic (e.g. a p- oxybenzoic ester) but pref. including no ethanol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to an antiseptic agent, raffinose, which is excellent in antiseptic power and can reduce the amount of preservatives such as p-hydroxybenzoic acid ester, and has an irritating effect on the skin. Related to cosmetics that have been alleviated.

[0002]

2. Description of the Related Art Conventionally, some consumers show skin hypersensitivity to preservatives such as p-hydroxybenzoic acid esters incorporated in cosmetics.
JP-A-3338, JP-A-10-53510, JP-A-10-279417 and the like have proposed various methods for reducing the amount of preservative used. Further, ethanol blended in cosmetics has antiseptic properties, but depending on the properties of the skin, a dosage form free of ethanol is desired. On the other hand, raffinose is described in many patent publications as a kind of polyhydric alcohol or polysaccharide, and it is a known substance to be simply added to cosmetics. According to Kamoi et al. (Fragrance Journal, July 1998, pp. 57-62), raffinose is known to be capable of controlling intestinal bacteria.

[0003]

That is, an object of the present invention is to provide a preservative auxiliary agent capable of reducing the amount of a preservative, and a cosmetic having excellent preservative power and low irritation.

[0004]

The present inventors examined whether raffinose has the ability to assist the preservative effect of preservative compounds such as paraoxybenzoate, phenoxyethanol and polyhydric alcohol. As a result, it has been found that raffinose has an effect of assisting preservative power, and that a hypoallergenic cosmetic with a reduced amount of preservative can be obtained.

A first aspect of the present invention is an antiseptic auxiliary comprising raffinose.

A second aspect of the present invention is a hypoallergenic cosmetic containing the above-mentioned preservative aid and another preservative.

[0007] The third invention is that raffinose is 0.1 to 2
The low-irritant cosmetic composition contains 0% by weight and does not contain ethanol.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Raffinose used in the present invention is a kind of trisaccharide and is O-α-D-galactopyranosyl- (1,6) -O-α-D-glucopyranosyl- (1,1).
2) A substance having a structure of -β-D-fructofuranoside. Raffinose can be obtained from eucalyptus manna, sugar beet molasses, cottonseed, and the like, but is most preferable because it is derived from sugar beet molasses. Raffinose may be anhydrous or pentahydrate, but it is preferable to use pentahydrate because the supply is stable. It is preferable to use raffinose having a purity of 99% or more in consideration of quality stability.

The amount of raffinose used in the present invention is as follows:
Preferably 0.1 to 2 with respect to the total amount of the hypoallergenic cosmetic.
It is 5% by weight, more preferably 1 to 20% by weight, still more preferably 3 to 10% by weight. Within this range, the formulation can be made while reducing the amount of preservative compound without sacrificing the feel of the formulation.

In the present invention, a preservative other than raffinose is used in combination with raffinose in a hypoallergenic cosmetic, and other preservatives include, for example, methyl paraoxybenzoate and ethyl paraoxybenzoate. Esters, paraoxybenzoic acid esters such as butyl paraoxybenzoate and propyl paraoxybenzoate, phenoxyethanol, and polyhydric alcohols such as 1,3-butylene glycol and dipropylene glycol having auxiliary preservatives, lower alcohols, and plants An extract and a chemically modified product thereof are exemplified, and the amount of the extract in the hypoallergenic cosmetic is preferably 0.05 to 95% by weight based on the total amount of the hypoallergenic cosmetic. . Among them, in particular, paraoxybenzoic acid ester and phenoxyethanol are highly effective for preservation, and the amount of the preservative is 0.05 to 1.0 as the total amount of the preservative with respect to the total amount of the hypoallergenic cosmetic. weight%
Is preferable, and within this range, it is appropriately selected in consideration of the blending amount of trehalose.

Further, among the lower alcohols, ethanol has a problem that it is very irritating to the skin. Therefore, in the present invention, a sufficient antiseptic effect can be obtained even if ethanol is not contained. Particularly preferred, even when it is included, the content is preferably less than 6% by weight based on the total amount of the hypoallergenic cosmetic.

The hypoallergenic cosmetics of the present invention include, in addition to the above components, oils and powders (pigments,
Pigments, resins), fluorine compounds, resins, surfactants, tackifiers, fragrances, UV absorbers (including organic and inorganic.
-A or B), moisturizers, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, neutralizers, pH adjusters, insect repellents, enzymes and other components. Can be appropriately used within a range where the object of the present invention can be achieved.

The oils include volatile and non-volatile oils, solvents and resins usually used in cosmetics, and may be liquids, pastes or solids at room temperature, but liquids excellent in handling are preferred. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyl dodecanol, isostearic acid, undecylenic acid, fatty acids such as oleic acid,
Myristyl myristate, hexyl laurate, decyl oleate, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate,
Esters such as diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, petrolatum, squalane, waxes such as lanolin, reduced lanolin, carnauba wax, mink oil, cocoa butter, coconut oil, palm Fats and oils such as kernel oil, camellia oil, sesame oil, castor oil, and olive oil, ethylene / α-olefin / co-oligomer, and the like.

Examples of other forms of oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified Organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amodimethicone, amino-modified organopolysiloxane,
Examples include silicone compounds such as silicone gel, acrylic silicone, trimethylsiloxysilicic acid, and silicone RTV rubber, and fluorine compounds such as perfluoropolyether, pitch fluoride, fluorocarbon, and fluoroalcohol.

The components such as humectants include, for example, ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin,
-Methyl-1,3-butanediol, sorbitol, erythritol, mannitol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. No. Further, these chemically modified products can also be used.

As the powder, red No. 104, red 201
No. 4, Yellow No. 4, Blue No. 1, Black No. 401, etc., Lake No. 4 such as Yellow No. 4 Al Lake, Yellow No. 203 Ba Lake, Nylon Powder, Silk Powder, Urethane Powder, Teflon Powder, Silicone Powder, Polymethacryl Methyl acid powder, cellulose powder, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, black iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine, navy blue, zinc oxide,
White pigments such as titanium oxide and cerium oxide, extenders such as talc, mica, sericite, kaolin, plate-like barium sulfate, pearl pigments such as mica titanium, barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, magnesium silicate, etc. Metal salts, inorganic powders such as silica and alumina, bentonite, smectite, boron nitride and the like. The shape of these powders (spherical, rod-like, needle-like, plate-like, irregular, flake-like, spindle-like, etc.) is not particularly limited.

These powders may be subjected to conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, and the like.
Titanium coupling agent treatment, oil treatment, N-acylated lysine treatment, polyacrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, etc. No problem.

Examples of the solvent include purified water, cyclic silicone, light liquid isoparaffin, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, and next-generation Freon.

As the surfactant, for example, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be used. More specifically, fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, alkyl ether sulfate, alkyl amide sulfate, alkyl phosphate,
Anionic surfactants such as alkylamidophosphates, alkylloylalkyltaurates, N-acylamino acid salts, sulfosuccinates, perfluoroalkylphosphates, alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethyl bromide Cationic surfactants such as ammonium, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, and behenyltrimethylammonium bromide, alkanolamide laurate, POE sorbitan fatty acid ester, POE glycerin fatty acid ester, P
Nonionic surfactants such as OE fatty acid ester and polyether-modified silicone, carboxybetaine type, amidobetaine type, sulfobetaine type, hydroxysulfobetaine type, amidosulfobetaine type, phosphobetaine type,
Examples include amphoteric surfactants such as aminocarboxylate type, imidazoline derivative type and amidoamine type. In addition, natural surfactants such as saponins and sugar surfactants can also be used.

Examples of the physiologically active ingredient include substances that give some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, UV protection agents, slimming agents, tightening agents, antioxidants, hair growth agents,
Examples include a hair restorer, a blood circulation promoter, a desiccant, a cooling agent, a warming agent, vitamins, amino acids, a wound healing promoter, a stimulant, an analgesic, a cell activator, and an enzyme component. Among them, natural animal and plant extract components, seaweed extract components, and crude drug components are particularly preferable. In the present invention, it is preferable to mix one or more of these physiologically active components.

Examples of these suitable components include, for example, Ashitaba extract, Avocado extract, Amacha extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Apricot kernel extract, Ginkgo extract, Fennel extract, Turmeric extract, Oolong tea extract , Agetsu extract, Echinashi leaf extract, Japanese gourd extract, Japanese oak extract, Ouren extract, Barley extract, Hypericum extract, Odrichia extract, Dutch mustard extract,
Orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, kawagomugi extract, licorice extract, calcade extract, kyoku extract, kiwi extract, kina extract, cucumber extract, guanosine ,
Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentian extract,
Black tea extract, yeast extract, burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen,
Cowberry extract, Saishin extract, Psychoextract, Saitai extract, Salvia extract, Sabonso extract, Sasa extract, Hawthorn extract, Sansho extract, Shiitake extract, Jio extract, Shikon extract, Perilla extract, Shinanoki extract, Shimotsukeiso extract, Peony extract, Shobu root extract , Birch extract, horsetail extract, vegetative extract, hawthorn extract,
Western elderberry extract, Achillea millefolium extract, Common mint extract, Sage extract, Genus mallow extract, Senkyu extract, Assembly extract, Soybean extract, Tissou extract, Thyme extract, Tea extract, Clove extract, Chigaya extract, Chimpanzee extract, Touki extract, Calendula extract, Tonin extract , Spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, nobara extract, hibiscus extract, bakkumondou extract, parsley extract, honey, hamamelis extract, Parietaria extract, chickpea extract, bisabolol, loquat extract, coltsfoot extract , Fukinotou extract, kukuroyou extract, butcher bloom extract, grape extract, propolis, loofah extract, safflower Vinegar, peppermint extract, lime extract, button extract, hops extract, pine extract, horse chestnut extract, skunk cabbage extract, Sapindus extract, Melissa extract, peach, cornflower extract, eucalyptus extract, saxifrage extract, Yuzuekisu,
Yokuinin extract, mugwort extract, lavender extract,
Examples include apple extract, lettuce extract, lemon extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like.

Also, biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sodium lactate, urea, sodium pyrrolidonecarboxylate, Moisturizing ingredients such as betaine and whey, sphingolipids, ceramides,
Cholesterol, cholesterol derivatives, oily components such as phospholipids, ε-aminocaproic acid, glycyrrhizic acid,
anti-inflammatory agents such as β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, hydrocortisone, vitamin A,
Vitamins such as B ₂ , B ₆ , C, D, E, calcium pantothenate, biotin, nicotinamide, vitamin C ester, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, and tocopherol Antioxidants such as carotenoids, flavonoids, tannins, lignans, saponins, cell activators such as α-hydroxy acids and β-hydroxy acids, γ-oryzanol, blood circulation promoters such as vitamin E derivatives, retinol, retinol derivatives and the like Wound healing agent, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, whitening agents such as glutathione, cepharanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, dl α- tocopherol acetate dl-
α-tocopherol, nicotinic acid, nicotinic acid derivatives,
Calcium pantothenate, D-pantothenyl alcohol, acetyl pantothenyl ethyl ether, biotin,
Allantoin, isopropylmethylphenol, estradiol, ethinylesteradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, tacanal, camphor, salicylic acid, vanillyl nonylate, vanillyl nonanoate, pyrocton olamine, glyceryl pentadecanoate, l-menthol, Mononitroguaiacol, resorcinol, γ-aminobutyric acid,
Benzethonium chloride, mexiletine hydrochloride, auxin,
Examples include female hormones, tincture tincture, cyclosporin, zinc pyrithione, hydrocortisone, minoxidil, polyoxyethylene sorbitan monostearate, peppermint oil, and hair restorer such as sasanishiki extract.

Examples of the resin and the adhesive include acrylic acid ester / methacrylic acid ester copolymer (plus size, manufactured by Yoyo Kagaku) and vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC) , Vinyl acetate /
Crotonic acid / vinyl neodecanoate copolymer (28-2
930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP),
t-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (Rubimer, manufactured by BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Ruviscol VAP, manufactured by BASF), vinyl acetate / crotonic acid Copolymer (Rubiset CA, BA
SF), vinyl acetate / crotonic acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, manufactured by BASF), acrylate / acrylamide copolymer (Ultrahold) , Manufactured by BASF)
Vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, manufactured by ISP),
Carboxyvinyl polymer (Carbopol, BFG
OODRICH), anionic polymer compounds such as cross-linked polyacrylic acid (Pemulen, BF GOODRICH), acetic acid amphoteric dialkylaminoethyl methacrylate polymer (Yukaformer, manufactured by Mitsubishi Chemical Corporation), octylacrylamide acrylate / Amphoteric polymer compounds such as / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, manufactured by NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, manufactured by ISP), methylvinylimidazo Cationic polymer compounds such as ium chloride / vinylpyrrolidone copolymer (Rubicoat, manufactured by BASF), polyvinylpyrrolidone (Rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (Rubisco) VA, manufactured by BASF), vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (Copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, I
Nonionic high molecular compounds such as those manufactured by SP Co., Ltd.). In addition, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally occurring polymer compounds such as galactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, gellan gum, and dextran can also be suitably used.

It is also preferred that the hypoallergenic cosmetic of the present invention impart an ultraviolet protection effect. In this case, it is preferable to use an ultraviolet absorber as shown below.

Examples of the ultraviolet absorber include inorganic type and organic type. Inorganic type includes fine particle titanium oxide and fine particle zinc oxide. Examples of the organic type ultraviolet absorber include 2-ethylhexyl paramethoxycinnamate. 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid, 2,2 ′
-Dihydroxy-4-methoxybenzophenone, p-methoxyhydrocinnamic acid diethanolamine salt, paraaminobenzoic acid (hereinafter abbreviated as PABA), ethyldihydroxypropyl PABA, glyceryl PABA, homomenthyl salicylate, methyl-O-aminobenzoate,
2-ethylhexyl-2-cyano-3,3-diphenyl acrylate, octyl dimethyl PABA, octyl methoxycinnamate, octyl salicylate, 2-phenyl-
Benzimidazole-5-sulfate, triethanolamine salicylate, 3- (4-methylbenzylidene) camphor, 2,4-dihydroxybenzophenine, 2,2 ′,
4,4′-tetrahydroxybenzophenone, 2,2 ′
-Dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-N-octoxybenzophenone, 4-isopropyldibenzoylmethane, butylmethoxydibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 2-ethylhexyl 5-dioxo-1-imidazolidine propionate, a polymer derivative thereof, a silane derivative, and the like. Further, among these absorbents, preferably, 4-tert-butyl-
What sealed 4'-methoxydibenzoylmethane in the polymer can also be used preferably.

The hypoallergenic cosmetics of the present invention include, for example, basic cosmetics such as emulsions, creams, lotions, calamine lotions, sunscreens, suntans, aftershave lotions, preshave lotions, packs, anti-acne cosmetics and essences. Ingredients, foundation, white powder, eyeshadow, eyeliner, eyebrow,
Make-up cosmetics such as teak, lipstick and nail color,
Shampoo, rinse, conditioner, hair color,
Hair cosmetics such as hair tonics, set preparations, body powders, deodorants, soaps, body shampoos, bath additives,
Hand soap, perfume and the like can be mentioned.

[0027] The dosage form of the hypoallergenic cosmetic of the present invention includes:
Conventionally known dosage forms such as two-layered, water-in-oil emulsion, oil-in-water emulsion, gel, spray, mousse, oil, solid, sheet and the like can be used.

[0028]

The present invention will be described in detail below with reference to examples and comparative examples. In addition, the methods of the preservative power confirmation test and the stinging test, which is an irritation test, of the cosmetics prepared in Examples and Comparative Examples are shown below.

[Preservation test for antiseptic power] 1 g of a sample according to a conventional method
10 4 cfu (colony forming unit), 4
After inoculating 10 4 cfu of the yeast pre-cultured for 10 hours and 10 6 cfu of the bacteria pre-cultured for 24 hours, the number of surviving microorganisms after 2 weeks was confirmed by culture, and the antiseptic property was evaluated in three stages.

[Stinging test] To 10 panelists sensitive to salicylic acid (feeling crisp)
Samples of Examples and Comparative Examples were used one by one every three days, and whether or not there was an abnormality in the skin and whether or not a crisp feeling was felt were counted in a questionnaire format. The evaluation results were based on the number of panelists who did not have abnormal skin or did not feel crisp. Therefore, the formulation was judged to be less irritating as the number of panelists having no problem increased.

Example 1 A lotion was obtained according to the following formulation. The unit of the compounding amount is% by weight, and the purity of raffinose is 99.7%.
Raffinose pentahydrate was used.

Dipropylene glycol 5.0 Glycerin 5.0 Phenoxyethanol 0.2 Raffinose 8.0 Citric acid 0.23 Sodium citrate 0.07 Tetrasodium edetate qs Purified water balance

This lotion had a refreshing feel.

Example 2 A product was obtained in the same manner as in Example 1 except that ethanol was used instead of dipropylene glycol in Example 1.

Comparative Example 1 A product was obtained in the same manner as in Example 1 except that purified water was used instead of raffinose.

The evaluation results of the examples and the comparative examples are shown below.

[0037]

From the evaluation results of the examples and comparative examples, it was found that the examples of the present invention achieved both antiseptic and low irritation. Among them, Example 1 containing no ethanol was particularly hypoallergenic. In addition, the examples showed a feeling with no problem in sensory characteristics. On the other hand, in the comparative example in which raffinose was not blended, it was found that there was a problem in the evaluation of the antiseptic and hypoallergenicity.

[0039]

As described above, the present invention provides a cosmetic composition having a new antiseptic power auxiliary agent, raffinose, which is excellent in antiseptic power even when the amount of the antiseptic agent is reduced and which has reduced irritation to the skin. It is clear that a fee is available.

Claims (3)

[Claims] 1. An antiseptic auxiliary comprising raffinose. 2. A hypoallergenic cosmetic containing the preservative aid according to claim 1 and another preservative. 3. The hypoallergenic cosmetic according to claim 2, which contains 0.1 to 20% by weight of raffinose and does not contain ethanol.