JP2020158396A - Erythritan derivative and cosmetic containing the same - Google Patents

Abstract

To provide an erythritan derivative realizing excellent usability while retaining excellent effect of erythritan, and a cosmetic containing the derivative.SOLUTION: The invention provides an erythritan derivative represented by the general formula (1) in the figure, and a cosmetic containing the derivative. (In the formula, R1 and R2 are identical to or different from each other and each represent a C1-4 hydrocarbon group or H, where R1 and R2 are not simultaneously H.)SELECTED DRAWING: None

Description

The present invention relates to erythritan derivatives and cosmetics containing them.

Erislitan, also known as 1,4-anhydroerythritol or 3,4-dihydroxytetrahydrofuran, is a compound having two hydroxyl groups in the molecule obtained by intramolecular dehydration of one molecule of water from erythritol. Erythritol can be produced using erythritol as a raw material (Patent Document 1), and erythritol as a raw material is industrially produced by a fermentation method using plant-derived glucose as a raw material and using an erythritol-producing bacterium. Erislitan is known to be applied as a constituent of cold storage heat materials and polyesters, or as a synthetic intermediate for tetrahydrofuran, dihydrofuran, C4 alcohols, etc., but its application to the cosmetics field has not been known so far. Therefore, the present inventors have focused on the effect of erythritan as a raw material for cosmetics, and have proposed a technique for applying erythritan to cosmetics (Patent Document 2). However, no derivative of erythritan has been known so far, and no application to cosmetics is known.

Japanese Patent Application Laid-Open No. 06-116256 Japanese Patent Application No. 2017-169963

As described in Patent Document 2, erythritan is excellent in safety, stability, water solubility, moisturizing property, and usability, and can be preferably used in cosmetics as a plant-derived multivalent alcohol component. The usability was not always satisfactory. Therefore, an object of the present invention is to provide a derivative of erythritan, which retains the excellent effect of erythritan and is more excellent in usability, and a cosmetic containing the derivative.

（式中、Ｒ１、Ｒ２は、それぞれ同一又は異なっていてもよい、炭素数１〜４の炭化水素基又は水素原子を表す。ただし、Ｒ１、Ｒ２は同時に水素原子にはならない。）

As a result of diligent studies in view of such a situation, the present inventors have found that an erythritan derivative represented by the following general formula (1) or (2) can solve the above-mentioned problems, and have completed the present invention.

(In the formula, R1 and R2 represent hydrocarbon groups or hydrogen atoms having 1 to 4 carbon atoms, which may be the same or different, respectively. However, R1 and R2 do not become hydrogen atoms at the same time.)

The erythritan derivative of the present invention is superior to erythritan in usability while retaining the effects of erythritan such as safety, stability, water solubility, and moisturizing property. Further, the derivative of erythritan of the present invention is advantageous over erythritan in that it is excellent in solubility of a poorly soluble component.

（式中、Ｒ１、Ｒ２は、それぞれ同一又は異なっていてもよい、炭素数１〜４の炭化水素基又は水素原子を表す。ただし、Ｒ１、Ｒ２は同時に水素原子にはならない。）

The present invention relates to an erythritan derivative represented by the following general formula (1) or (2), and a cosmetic containing the derivative.

(In the formula, R1 and R2 represent hydrocarbon groups or hydrogen atoms having 1 to 4 carbon atoms, which may be the same or different, respectively. However, R1 and R2 do not become hydrogen atoms at the same time.)

Erythritan, which is a starting material for the erythritan derivative of the present invention, is a compound obtained by intramolecular dehydration of one molecule of water from erythritol. The method for producing erythritan is not particularly limited, and it may be produced by a known production method. For example, a method in which a strongly acidic ion exchange resin is used as a catalyst and the reaction is carried out under reduced pressure (Japanese Patent Laid-Open No. 6-116256), and a method in which p-toluenesulfonic acid is used as a catalyst and the reaction is carried out under reduced pressure (Japanese Patent Laid-Open No. 2007). -112764) and the like are known. Specifically, phosphoric acid, paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid and the like may be used as a catalyst with erythritol and heated at 100 to 200 ° C. under reduced pressure to carry out an intramolecular dehydration reaction. Further, as the solvent, water, heptane, hexane, cyclohexane, toluene, xylene and the like may be used. The obtained erythritol may be purified and used by a usual method, if necessary, and may contain unreacted erythritol or water produced by the reaction in addition to erythritol.
Since erythritol, which is a raw material of erythritol, is industrially produced by a fermentation method using plant-derived glucose as a raw material and using erythritol-producing bacteria, erythritol can be obtained as a plant-derived substance. Then, it is preferable to use such a plant-derived erythritol.

The method for producing the compound represented by the general formula (1) of the present invention is not particularly limited, and the compound may be produced by a known production method. Specifically, it can be obtained by reacting erythritan with an alkylaldehyde or alkyl ketone having the desired R1 and R2, or a dimethyl acetal compound thereof under an acidic catalyst to form a cyclic acetal. The R1 and R2 in the compound represented by the general formula (1) of the present invention are preferably a methyl group, an ethyl group and a propyl group, and most preferably a methyl group.

The method for producing the compound represented by the general formula (2) of the present invention is not particularly limited, and the compound may be produced by a known production method. Specifically, it is obtained by cyclically carbonic acid esterifying erythritan. Examples of the cyclic carbonate esterification method include a method using phosgene and a method of transesterifying with dialkyl carbonate such as dimethyl carbonate and diethyl carbonate. In the present invention, a production method by transesterification is preferable.

The erythritan derivative of the present invention retains the safety, stability, water solubility, moisturizing and other effects of erythritan, but is superior to erythritan in terms of smoothness, non-stickiness, and familiarity with the skin. Is. Further, the erythritan derivative of the present invention is advantageous over erythritan in that it is excellent in solubility of a poorly soluble component. Examples of the poorly soluble component include one or more selected from ceramides, sterols, and poorly soluble ultraviolet absorbers. More specifically, examples of the ceramides include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, sphingosine, phytosphingocin and the like, among which ceramide 1 and ceramide 2 , Ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7 are more preferable. Examples of sterols include cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, desmosterol, stigmasterol, citosterol, campesterol, brush casterol, phytosterol, ergosterol, and derivatives thereof such as oryzanol and sterol fatty acid ester. Of these, cholesterol, phytosterols and oryzanol are more preferred. Examples of the sparingly soluble ultraviolet absorber include bisethylhexyloxyphenol methoxyphenyltriazine, hexyl diethylaminohydroxybenzoyl benzoate, methylenebisbenzotriazolyltetramethylbutylphenol, t-butylmethoxydibenzoylmethane, and the like. Ethylhexyloxyphenol methoxyphenyltriazine and t-butylmethoxydibenzoylmethane are more preferable.

The amount of the erythritan derivative of the present invention blended in the cosmetics depends on the dosage form of the cosmetics, but is usually 0.01 to 90% by weight, preferably 0.05 to 50% by weight, based on the total amount of the cosmetics. %, More preferably 0.1 to 30% by weight.

The cosmetics of the present invention include water and additive components usually added to cosmetics as needed, such as oily bases, surfactants, alcohols, moisturizers, polymers / thickening / gelling agents, and antioxidants. Agents, preservatives, bactericides, chelating agents, pH regulators / acids / alkalis, UV absorbers, whitening agents, solvents, keratin exfoliating / dissolving agents, antipruritic agents, anti-inflammatory agents, antiperspirants, refreshing agents, antihistamines, astringents Agents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidizing agents, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes, nucleic acids, hormones , Inorganic powders, fragrances, pigments, etc. can be blended.

Oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, chimil alcohol, seraquil alcohol, bacil alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimerdiol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Higher grades such as palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eikosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, etc. Fatty acids and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts and other metal soaps, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light fluid Hydrocarbons such as isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalane, vaseline, solid paraffin; candelilla wax, carnauba wax, rice wax, wood wax, honey wax, Waxes such as Montan wax, Ozokerite, Celesin, Paraffin wax, Microcrystallin wax, Petrolatum, Fishertroph wax, Polyethylene wax, Ethylene-propylene copolymer; Palm oil, Palm oil, Palm kernel oil, Saflower oil, Olive oil, Himashima oil , Avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil , Wheat germ oil, flax oil, cotton seed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil and other vegetable fats and oils; beef fat, Animal fats and oils such as milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as whale wax, lanolin, orange raffy oil; liquid lanolin, reduced lanole Phospholipids such as phosphorus, adsorption-purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine , Phospholipid ethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin and other sphingophospholipids, phosphatidic acid, lysolecithin and other phospholipids; hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (cholesteryl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl) / Behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), acylsarcosine alkyl esters such as N-lauroyl sarcosin isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl Phospholipids such as phytosteryl isostearate, phytosteryl oleate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex Phospholipid complexes such as body; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanate, hexyldecyl octanate, isotorideyl isononanoate, isononyl isononanoate Octyl, isotridecyl isononanoate, isodecyl neopentate, isotridecyl neopentanoate, isopentanoate Stearyl, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinic acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hardened castor oil isostearate, ethyl oleate, avocado oil Ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, Monoalcoholic carboxylic acid esters such as dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated monoisostearate castor oil, Oxyacid esters such as γ-ercalactone; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid /) Glyceryl (stearate), hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl beecosanate, glyceryl trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicaprylic acid Neopentyl glycol acid, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythricyl tetraoctanoate, hydrogenated rosin pentaerythricyl, ditrimethylolpropane triethylhexanoate, (isostea) Acid / sebacic acid) ditrimethylolpropane, pentaerythricyl triethylhexanoate, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (ercaic acid) / Isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, diss Polyhydric alcohol fatty acid esters such as glycol thearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopenate, 2,4-diethyl-1,5-pentanediol dineopenate; Diisopropyl, diisostearyl dimersylinolate, dimerselynolate di (isostearyl / phytosteryl), dimergylinolic acid (phytosteryl / behenyl), dimerserinolic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), die Dimeric acid or derivatives of dimer diols such as dimer dilinoleyl dimersinorail, dimer dilinoleyl diisostearate, hydrogenated rosin condensate, dimer dilinoleic acid hardened castor oil, hydroxyalkyl dimer dilinoleil ether; Palm oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), Fatty acid alkanolamides such as palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethyl). Polysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber , Amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cationic-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, Alkyl-modified silicone, fatty acid-modified silicone, alkylether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cationic-modified and polyether-modified siricho Silicones such as amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, polysiloxane / oxyalkylene copolymers; perfluorodecane, Fluoro-based oils such as perfluorooctane and perfluoropolyether are preferred.

Examples of the moisturizing agent / feel improving agent include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, and the like. Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymers and their polymers; diethylene glycol monoethyl ether Glycolalkyl ethers such as (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10, polyglyceryl-10 tetradecanedioate, cyclohexanedicarboxylic acid Water-soluble esters such as bisethoxydiglycol; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, martitol; glucose, fructose, galactose, mannose, treose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, Trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, Heparin and derivatives, saccharides such as pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer and derivatives thereof; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate , Caronine sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Dicarboxylic acids and salts such as sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamate, glutamine, asses Amino acids such as paragin, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, Hydroxypropyl ammonium chloride Hydrolyzed collagen, elastin-degraded peptide, keratin-degraded peptide, hydrolyzed keratin, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat protein Protein peptides such as degrading peptides, hydrolyzed wheat proteins, casein-degrading peptides, acylated peptides and their derivatives; acylated peptides such as palmitoyl oligopeptides, palmitoyl pentapeptides and palmitoyl tetrapeptides; silylation peptides; lactic acid bacteria culture solution , Yeast extract, eggshell membrane protein, bovine submandibular gland mutin, hypotaurine, sesame lignan glycoside, glutathione, albumin, lactose; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, hetima Animal / plant extracts such as water, chamomile extract, kanzo extract, comfrey extract, silk extract, isayoibara extract, sardine extract, eucalyptus extract, and melilot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides, sphingoglycolipids, ceramides and ceramides such as sugar ceramide-containing extracts are preferable.

Preferred examples of the surfactant include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. The HLB of the surfactant is not particularly limited and can be used from a low HLB of about 1 to a high HLB of about 20, and it is also preferable to combine a low HLB and a high HLB. Examples of preferred surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; laureth. Polyoxyethylene alkyl sulfates such as sodium sulfate and triethanolamine laureth sulfate; sodium cocoyl methyl taurine, potassium cocoyl methyl taurine, sodium lauroyl methyl taurine, sodium myristyl methyl taurine, sodium lauroyl methyl alanine, sodium lauroyl sarcosin, and lauroyl sarcosin triethanol. Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroyl glutamate; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine. , Acyl amino acid salts such as lysine Na dilauroyl glutamate; Polyoxyethylene alkyl ether acetate salts such as sodium laures acetate; Sulfonic acid ester salts such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylates; Acyl lates Polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; hardened coconut oil fatty acid fatty acid glyceride sulfate such as sodium glycerin sulfate; alkylbenzene polyoxyethylene sulfate; olefin sulfonate such as α-olefin sulfonate; sulfosuccin Alkyl sulfosuccinates such as sodium lauryl sulphate, sodium dioctyl sulfosuccinate; alkyl ether sulfosuccinates such as sodium laures sulfosuccinate, monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; tetradecyl Alkyl benzene sulfonates such as sodium benzene sulfonate, triethanolamine tetradecyl benzene sulfonic acid; alkyl naphthalene sulfonate; alkane sulfonate; α-sulfo fatty acid methyl ester salt; acyl acetylionate; alkyl glycidyl ether sulfonate Alkyl sulfoacetate; Alkyl sulfoacetate such as sodium laureth phosphate, sodium dilaures phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; alkyl phosphate such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether Phosphate; fatty acid amide ether phosphate; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone; Non-ionic surfactants include laures (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steares (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), and isosteares (poly). Polyoxyethylene alkyl ethers with various polyoxyethylene additions such as oxyethylene isostearyl ethers) and octyldodeces (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene cured castor oil, poly Oxyethylene castor oil, polyoxyethylene cured castor oil monoisostearate, polyoxyethylene cured castor oil triisostearate, polyoxyethylene cured castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene cured castor oil maleic acid, etc. Polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / Polyoxyethylene / polyoxypropylene alkyl such as polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether, etc. Ether; Polyoxyethylene / Polyoxypropylene glycol; (Poly) glycerin such as PPG-9 diglyceryl Polyoxypropylene glycol; Glyceryl stearate, Glyceryl isostearate, PA Glyceryl luminate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocotton glycerin fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, α, α'-pyroglutamate oleate glycerin, monostearate glycerin malic acid Partial esters of glycerin fatty acids; polyglyceryl-2, 3, 4, 5, 5, 6, 8, 10, glyceryl distearate-6, 10, polyglyceryl tristearate-2, polyglyceryl decastarate -10, polyglyceryl isostearate-2, 3, 4, 4, 5, 6, 8, 8, 10, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate- 2. Polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate 3, 4, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, polyglyceryl trioleate -2, Polyglycerin fatty acid ester such as polyglyceryl-10 decaoleate; ethylene glycol monofatty acid ester such as ethylene glycol monostearate; propylene glycol monofatty acid ester such as propylene glycol monostearate; pentaerythritol partial fatty acid ester; sorbitol partial fatty acid Estel; multitole partial fatty acid ester; multitall ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2 -Sorbitan fatty acid esters such as diglycerol sorbitan ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate; sugar derivative partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester and trehalose undecylate; alkyl glucosides such as caprylyl glucoside; Alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate and other polyoxyethylene fatty acid mono and diesters; polyoxy Ethylene / propylene Recall fatty acid ester; polyoxyethylene glycerin fatty acid ester such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene glycerin monostearate; polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid esters such as monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate , Polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate and other polyoxyethylene sorbitol fatty acid esters; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene sorbitol mitsuro and the like. Ethylene animal and vegetable oils and fats; alkyl glyceryl ethers such as isostearyl glyceryl ethers, chimyl alcohols, ceracyl alcohols, and batyl alcohols; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine Condensates; Natural surfactants such as saponin and sophorolipid; Polyoxyethylene fatty acid amide; Palm oil fatty acid monoethanolamide (cocamide MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA) ), Laurate diethanolamide (lauramide DEA), laurate monoisopropanolamide (lauramide MIPA), palmitate monoethanolamide (partamide MEA), palmitate diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl MEA) And other fatty acid alkanolamides; alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkylethoxydimethylamine oxides; polyoxyethylene alkyl mercaptans; polyether modifications such as dimethicone copolyol. Silicone, polysiloxane / oxyalkylene copolymer, polyglycerin modification Silicone-based nonionic surfactants such as silicones and sugar-modified silicones; among cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, stealtrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; Alkyltrimethylammonium bromide such as stearyltrimonium bromide; Dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethyl Alkyl ether amines such as amines and their salts or quaternary salts; fatty acid amide quaternary ammonium salts such as ethyl sulfate long chain branched fatty acids (12-31) aminopropyl ethyl dimethyl ammonium, ethyl sulfate lanolin fatty acids aminopropyl ethyl dimethyl ammonium; Polyoxyethylene alkylamine and its salt or quaternary salt; alkylamine salt; fatty acid amide guanidium salt; alkyl etheraminemonium salt; alkyltrialkylene glycol ammonium salt; benzalconium salt; benzethonium salt; cetylpyridinium chloride, etc. Pyridinium salt; imidazolinium salt; alkylisoquinolinium salt; dialkylmoriphonium salt; polyamine fatty acid derivative; amino-modified silicones such as aminopropyldimethicone and amodimethicone, cationic-modified silicones, cationic-modified and polyether-modified silicones, amino Silicone-based cationic surfactants such as modified and polyether-modified silicones; N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryl dimethylaminoacetic acid betaine) for amphoteric surfactants; cocamidopropyl Fatty acids such as betaine and lauramidopropyl betaine Alkylamide alkyl-N, N-dimethyl amino acid betaine; imidazoline-type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaine such as alkyldimethyltaurin; alkyldimethylaminoethanol sulfate and the like Sulfate-type betaine; Phosphate-type betaine such as alkyldimethylaminoethanol phosphate ester; Sphingophosphory lipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin , Hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as lecithin hydroxide; silicone-based amphoteric surfactants, etc .; , Polyvinyl alcohol, sodium alginate, starch derivative, tragant gum, acrylate / alkyl methacrylate copolymer; various silicone-based surfactants are preferable.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farcerelan, karaya gum, trolley aoi, cara gum, tragant gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potatoes, wheat; xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin , Chitosan, agar, casso extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts such as sodium thereof, methyl hydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethyl Cellulose sulfate, crystalline cellulose, cellulose powder and other cellulose and derivatives thereof; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch and methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenyl succinate and the like. Alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpidridone / vinyl alcohol copolymer, polyvinylmethyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene Polyoxypropylene copolymer; amphoteric methacrylate copolymer such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrelites / stearyl acrylate / ethylamine methacrylate) copolymer; (dimethicone / vinyldimethicone) cloth Polymers, (alkyl acrylate / diacetone acrylamide) copolymers, (alkyl acrylate / diacetone acrylamide) copolymers AMP; partially saponified polyvinyl acetate, maleic acid copolymers; vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymers; Acrylic resin alkanolamine; polyester, water-dispersible polymer; polya Crylamide; polyacrylic acid ester copolymer such as ethyl polyacrylic acid, carboxyvinyl polymer, salt such as polyacrylic acid and sodium salt thereof, acrylic acid / methacrylic acid ester copolymer; acrylate / alkyl methacrylic acid Polymers: cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39. -Diallyldimethylammonium chloride-acrylamide copolymer, acrylic acid-cationized methacrylic acid ester copolymer, acrylic acid-cationized methacrylic acid amide copolymer, polyquaterium-47 and other acrylic acid-methyl acrylate-chloride Methacylamide propyltrimethylammonium copolymer, choline chloride methacrylate polymer; cationized oligosaccharide, cationized dextran, cationized polysaccharide such as guarhydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polyquaternium-51 and the like. 2-Polymer of methacryloyloxyethyl phosphorylcholine and polymer with butyl methacrylate copolymer, etc .; acrylic resin emulsion, ethyl polyacrylate emulsion, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, natural rubber latex, synthetic Polymer emulsions such as latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and Its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin myristinate; silicic anhydride, fuming silica (ultrafine anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, Bentonite, hectrite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters are preferred.

Examples of solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyldiol. Kind: Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as: ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, glycol ether esters such as propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl Preferables include propellants such as alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation freon; LPG, dimethyl ether, and carbon dioxide.

Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; bisulfite derivatives such as propyl bisulfite; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfites such as sodium thiosulfite; metahydrosulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferable. Is listed as. As the reducing agent, thioglycolic acid, cysteine, cysteamine and the like are preferable. As the oxidizing agent, hydrogen peroxide solution, ammonium persulfate, sodium bromate, percarbonate and the like are preferable.

Examples of antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane. 1,2-Alcandiols such as diols; Alkylglyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); Salicylic acid; Sodium benzoate; Isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; Imidazo Linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zincpyrythion, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid, halocarban, hexachlorophenol, hinokithiol; other phenols such as phenol, isopropylphenol, cresol, timol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion However, when used as an antibacterial agent or an antiseptic for the purpose of antiseptic, from the viewpoint of safety of cosmetics or external preparations for skin, phenoxyethanol; 1,2-pentanediol, 1,2-hexane It is more preferable to use 1,2-alkanediols such as diols and 1,2-octanediols; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ethers.

Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytate; ethidroic acid and the like. Phosphonic acid and salts such as sodium salts thereof; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphate; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid, tartrate acid are preferred. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol. Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Preferred are sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

As powders, mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, white mica, gold mica, synthetic mica, red mica, black mica, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, kay Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (eg zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, navy blue, carbon black, titanium oxide, fine particles and ultrafine titanium oxide, zinc oxide , Fine and ultrafine zinc oxide, alumina, silica, fumigant silica (ultrafine anhydrous silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with silicones such as hydrogen silicone and cyclic hydrogen silicone or other surface treatment agents such as silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate -Polymethylmethacrylate laminated powder, polyethylene terephthalate, aluminum, epoxy laminated powder, etc., urethane powder, silicone powder, Teflon (registered trademark) powder, and other organic powders and surface treatment powders of various sizes and shapes, organic and inorganic Composite powders are preferred. Inorganic salts include sodium chloride-containing salts such as salt, normal salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, ginger, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, etc. Aluminum / potassium sulfate (myoban), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphate Potassiums, calcium phosphates and magnesium phosphates are preferred.

Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, N, N-dimethylparaaminobenzoate ethyl. An benzoic acid-based ultraviolet absorber such as ester, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorber such as homomentyl-N-acetylanthranilate; salicylic acid And salicylic acid-based ultraviolet absorbers such as sodium salt, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanol phenylsalicylate; octylcinnamate, ethyl-4-isopropylcinnamate, methyl. -2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy Synnamete, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenyl Ceramic acid-based ultraviolet absorbers such as cinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrine), glycerylmono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and derivatives thereof; 2, 4-Dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-Methoxybenzophenone (oxybenzon-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4' Benzophenones such as −phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone UV absorbers; 3- (4'-methylbenziliden) -d, l-phenyl, 3-benziliden-d, l-phenyl; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 -Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoilmethane; 5-( 3,3-Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octylriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentandione, dimethoxybenzilidendioxoimidazolidine propionic acid Hydantin derivatives such as 2-ethylhexyl, phenylbenzimidazole sulfonic acid, terephthalilidene dicanfursulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives are preferred.

Examples of the whitening agent include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid, ascorbic acid phosphate ester salts such as ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester magnesium salt, and ascorbic acid. Ascorbic acid fatty acid ester such as tetraisopalmitic acid ester, ascorbic acid alkyl ether such as ethyl ether ascorbic acid, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid esters, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as: kodiic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, orizanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble kanzo extract, Nishikawayanagi extract, Yukinoshita extract Etc. Plant extracts are preferred.

Examples of vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxin hydrochloride, pyridoxin dioctanoate, and pyridoxin dipalmitate. Flavin adenine dinucleotide, cyanocobalamine, folic acids, nicotinic acids such as nicotinic acid amide and benzyl nicotinate, vitamin B group such as choline; vitamin Cs such as salts of ascorbic acid and its sodium; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as sodium ascorbic acid phosphate and magnesium ascorbic acid ester, tetra ascorbic acid Ascorbic acid fatty acid esters such as isoparmic acid ester, ascorbyl stearate, ascorvir palmitate, ascorvir dipalmitate, alkyl ascorbic acid ethers such as ethyl ascorbic acid, ascorbic acid glucosides such as ascorbic acid-2-glucoside, and their fatty acid esters. , Ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherols such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferrate, tocopherol phosphate, tocotrienol, and various other vitamin derivatives are preferable. Is listed as.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokithiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract. , Plant extracts such as Honoha extract are preferred. As hair growth agents, blood circulation promoters, and stimulants, plant extracts and tinctures such as senburi extract, togarashi tincture, ginger tincture, ginger extract, and cantarist tincture; capsaicin, nonylate valenylamide, gingerone, ictamol, and tannic acid. , Borneol, cyclanderate, cinnaridine, trazoline, acetylcholine, verapamil, cepharanthin, γ-orizanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-orizanol, nicotinic acid and nicotinic acid amide / benzyl nicotinate. Derivatives such as ester inositol hexanicotinate and nicotine alcohol, allantin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivative, stigmasterol or stigmasterol and its glycoside, minoxidil are preferable. Is listed as. As the hormones, estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like are preferable. Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cold sensitizers, warming agents, wound healing promoters, stimulants, analgesics, cell activators, etc. include retinols, retinoic acids, retinoins. Tocopheryl acid; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and its glycosides / esterified products, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and other α- or β-Hydroxy acids and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosin; creatin; ceramides, spingosins; caffeine, xanthin and its derivatives; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloids, fullerene and other antioxidants and active oxygen scavengers; catechins; quercetin and other flavones; isoflavones; gallic acid and ester sugar derivatives; tannins, sesamine, proto Polyphenols such as anthocyanidin, chlorogenic acid, apple polyphenols; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; kanzo extract-related substances such as glabridin, glabrene, liquilithin, isoliquiritin; lactoferrin Glycoside, gingerol; fragrance substances such as menthol, camphor, sedrol and its derivatives; capsaicin, vanillin and the like and derivatives; insect repellents such as diethyl toluamide; complexes of physiologically active substances and cyclodextrins are preferred. Can be mentioned.

Plant / animal / microbial extracts include iris extract, acitaba extract, asunaro extract, asparagus extract, avocado extract, flaxseed extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract. , Inchikou extract, Uikyo extract, Ukon extract, Woolong tea extract, Uwaurushi extract, Agetsu extract, Echinashi leaf extract, Enmeisou extract, Ogon extract, Oubaku extract, Ouren extract, Omugi extract, Otanenjinjin extract, Otogirisou extract, Odori kosou extract, Ononis extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi Extract, crow wheat extract, calcade extract, kanzo extract, oil-soluble kanzo extract, kiwi extract, kiou extract, kikurage extract, kina extract, cucumber extract, kiri leaf extract, guanosine, guava extract, kujin extract, kuchinashi extract, kumazasa extract, clara extract, walnut Extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, quail extract, gentiana extract, gennoshouko extract, tea extract, yeast extract, koboku extract, coffee extract, gobo extract, rice extract, rice Fermented extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss peach extract, saishin extract, psycho extract, saitai extract, saffron extract, salvia extract, sabonsou extract, sasa extract, sanzashi extract, sansha extract, sansho Extract, Shiitake extract, Jio extract, Shikon extract, Shiso extract, Shinanoki extract, Shimotsukesou extract, Jatoba extract, Shakuyaku extract, Shokyu extract, Shobu root extract, Shirakaba extract, White chrysanthemum extract, Sugina extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Seiyoukizuta extract, Seiyousanzashi extract, Seiyouniwatoko extract, Seiyounokogirisou extract, Seiyouhakka extract, Sage extract, Zeniaoi extract, Senkyu extract, Senburi extract, Souhakuhi extract, Daiou extract, Dai Zu extract, Taisou extract, Thyme extract, Dandelion extract, Local clothing extract, Tea extract, Chouji extract, Chigaya extract, Chinpi extract, Tea tree oil, Jincha extract, Togarashi extract, Touki extract, Tokinsenka extract, Tounin extract, Tohi extract, Dokudami extract, Tomato Extract, Natto extract, Carrot extract, Carrot extract, Novara extract, Hibiscus extract, Bakumondou extract, Hass extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Paris etalia extract, Hikiokoshi extract, Bisaborol, Hinoki extract, Bifizus bacterium extract, Biwa extract, Fukitanpopo extract, Fukinotou extract, Bukuryo extract, Butcher bloom extract, Grape extract, Grape seed extract, Propolis, Hechima extract, Benibana extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract , Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Yagurumagiku extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yuri extract, Yokuinin extract, Yomogi extract, Lavender extract, Green tea extract, Eggshell membrane extract, Apple extract, Louis Boss tea extract , Reishi extract, lettuce extract, lemon extract, lotus extract, lotus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, crackle extract and the like are preferable.

Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred examples of nucleic acids include ribonucleic acid and a salt thereof, deoxyribonucleic acid and a salt thereof, and disodium adenosine triphosphate.

As fragrances, acetylsedrene, amylcinnamaldehyde, allylamylglycolate, β-ionone, isoe super, isobutylquinolin, iris oil, iron, indol, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragor, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Oranthiol, Galax Solid, Carbachlor, L-Carbon, Camper, Cannon, Carrot Seed Oil, Clove Oil, Methyl Caynate, Geraniol, Geranyl nitrile , Isobornyl acetate, Geranyl acetate, Dimethylbenzylcarbinate acetate, Styralyl acetate, Cedril acetate, Telepinel acetate, pt-butylcyclohexyl acetate, Vetiberyl acetate, benzyl acetate, Linalyl acetate, Isopentyl salicylate, benzyl salicylate, Sandalwood oil, Santalol, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citroneral, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux Resinoid, cedarwood oil, sedren, sedrol, celery seed oil, thyme oil, damascon, damasenon, timol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinen, triplar, nerol, nonanaal, 2,6-nonazienol, nonalactone, pachori Alcohol, vanilla absolute, vanillin, basil oil, patcholi oil, hydroxycitroneral, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , Peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, muskketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil , Lavender oil, D-limonone, linalool, lylar, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, synthetic fragrances such as various essential oils and natural Fragrances and various blended fragrances are preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 3, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, Red 106, Red 2, Red 3, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207 , Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503 , Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow Legal dyes such as 405, Yellow 406, Yellow 407, Yellow 5; Other acidic dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26 and other nitro dyes; Disperse dyes; Inorganic white pigments such as titanium dioxide and zinc oxide; Inorganic red pigments such as iron oxide (Bengala) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow such as yellow iron oxide and yellow clay System pigments: Inorganic black pigments such as black iron oxide and low-order titanium oxide; Inorganic substances such as mango violet and cobalt violet Purple pigments; Inorganic green pigments such as chromium oxide, chromium hydroxide, cobalt titanate; Inorganic blue pigments such as ultramarine and dark blue; Titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored oxidation Pearl pigments such as titanium coated mica, bismuth oxychloride, fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthracinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsantin, chalcone, calsamine, Naftquinones such as quercetin, crosin, chlorophyll, curcumin, cochineal and ciconin, bixins, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, natural pigments and dyes such as rutin; p-phenylenediamine, toluene-2,5 Oxidizing dyes such as -diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and salts thereof. Body and couplers; auto-oxidizing dyes such as indolin; dihydroxyacetones are preferred.

As the water, in addition to normal water and purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytically acidic ionized water, ionized water, and cluster water are preferable.

In addition to these, cosmetic ingredient standards, compounding ingredient standards by cosmetic type, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), non-pharmaceutical ingredient standard, Japanese pharmacy, pharmaceutical additives Ingredients described in standards, food additive official regulations, etc., and Japanese and foreign patent gazettes and patent publication gazettes (including publication gazettes and republishing) whose international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the described ingredients, in known combinations, blending ratios, and blending amounts.

Examples of the type of cosmetics of the present invention include basic cosmetics, hair cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like.

Explaining the types of cosmetics of the present invention in more detail, basic cosmetics include soft lotions, astringent cleansers, cleansing cleansers, multi-layer cleansers and the like; emollient lotions, moisture lotions and milky lotions. , Nourishing Lotion, Nourishing Milk, Skin Moisture, Moistur Emulsion, Massage Lotion, Cleansing Lotion, Protect Emulsion, Makeup Lotion, Horny Smoother, Elbow Lotion, Hand Lotion, Body Lotion, etc. Emollient Cream, Nourishing Cream , Nourishing cream, Vanishing cream, Moisture cream, Night cream, Massage cream, Cleansing cream, Makeup cream, Base cream, Pre-makeup cream, Sunscreen cream, Suntan cream, Hair removal cream, Deodorant cream, Shaving cream, Horny Creams such as softening creams; Gels such as moisture gels; Essences such as moisturizing essences, whitening essences, and UV protection essences; Lipstick cosmetics such as liposome beauty liquids and liposome cosmetics; peel-off packs, powder packs, washing packs, oil packs, Packs and masks such as cleansing masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils, cleansing masks, powders, facial cleansers, etc.; sun protect, sun protectors, UV care milk, sun Sunscreen cleansers such as screens; are preferred.

Hair cosmetics include oil shampoo, cream shampoo, conditioning shampoo, indulgence shampoo, hair coloring shampoo, rinse-integrated shampoo, and other shampoos; rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair. Wax, Hair Gel, Water Grease, Set Lotion, Color Lotion, Hair Tonic, Hair Liquid, Pomade, Chick, Hair Cream, Hair Blow, Split Hair Coat, Hair Oil, Permanent Wave, Straight Perm, Oxidation Hair Dye, Hair Bleach , Hair color pretreatment, hair color after treatment, perma pretreatment, perma after treatment, hair manicure, hair restorer are preferable.

Preferable makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment. ..

Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfume paste, fragrance powder, perfume soap, body lotion, and bath oil.

Body cosmetics include body cleaning agents such as body shampoo; soaps such as cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, and synthetic cosmetic soap; deodorant such as deodorant lotion, deodorant powder, deodorant spray, and deodorant stick. Cosmetics; depigmenting agents, depilatory / depilatory agents; bathing agents; insect repellent sprays and other insectripellers are preferred.

As the external preparation for skin, it can be used in a dosage form such as an ointment, a patch, a lotion, a liniment, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

The dosage form of the cosmetic of the present invention includes emulsified cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type. Oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil type cosmetics, powder cosmetics, jelly cosmetics, gel cosmetics, paste cosmetics, emulsification Dosage forms such as polymer-type cosmetics, sheet-like cosmetics, mist-like cosmetics, and spray-type cosmetics are preferable.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

Example 1 Synthesis of isopropyridene erythritan In a 500 mL reactor equipped with a stirrer, a thermometer, a gas introduction tube, and a cooling tube, 70 g (0.67 mol) of erythritan, 195 g (3.36 mol) of acetone, and 0. 66 g (0.007 mol) was charged, 77 g (0.74 mol) of 2,2-dimethoxypropane was added dropwise at 30 ° C., and the mixture was further reacted at 30 ° C. for 3 hours. After neutralizing by adding 4.6 g of potassium carbonate, excess acetone was removed under reduced pressure. Then, ethyl acetate was added and extracted, and washed with water. The obtained ethyl acetate layer was concentrated to obtain 54 g of the target compound having the following structural formula (isopropyridene erythritan) as a liquid.

Example 2 Synthesis of erythritan carbonate 80 g (0.77 mol) of erythritan, 76.2 g (0.85 mol) of dimethyl carbonate, 28 in a 500 mL reactor equipped with a stirrer, a thermometer, a gas introduction tube, and a cooling tube. 1.48 g (0.008 mol) of% sodium methoxide (methanol solution) was charged and reacted at 64 ° C. for 3 hours, and then the temperature was raised to 90 ° C. while further removing the produced methanol. After cooling, ethyl acetate was added for extraction, and the mixture was washed with water. The obtained ethyl acetate layer was concentrated, recrystallized from ethyl acetate, and dried to obtain 45 g of the target compound (erythritan carbonate) having the following structural formula as acicular crystals.

Water solubility evaluation Table 1 shows the results of measuring the solubility of the compounds of Examples 1 and 2 in water at 25 ° C.

From the results in Table 1, it was found that the erythritan derivative of the present invention has water solubility and can be easily blended in general cosmetics like erythritan.

Evaluation of usability The usability of the compounds of Examples 1 and 2 in a 10 wt% aqueous solution was evaluated. Erythritan, 1,3-butylene glycol and glycerin were used for comparison. The evaluation is based on the sensuality of five panelists, and the following evaluation criteria are used for the four items of smoothness when applied to the skin, stickiness, familiarity with the skin, and moisturizing feeling (moisturizing feeling) after application. evaluated. The results are shown in Table 2.

Smoothness ◎: Very smooth ○: Smooth △: Slightly not smooth ×: Not smooth at all

Feeling of stickiness ◎: Very little sticky ○: Less sticky △: Slightly sticky ×: Very sticky

Familiar with the skin ◎: Very familiar ○: Familiar △: Slightly unfamiliar ×: Not familiar at all

Moisturizing feeling after application (moisturizing feeling)
◎: Very moist feeling ○: Moist feeling △: Slightly moist feeling ×: No moist feeling

From the results in Table 2, it was found that the erythritan derivative of the present invention has less stickiness, smoothness, and a feeling of familiarity with the skin as compared with the erythritan, 1,3-butylene glycol, and glycerin to be compared. ..

<Solubility of poorly soluble components>
The solubility of the poorly soluble component was evaluated for the compound of Example 1. Ellisritan was used for comparison. As the sparingly soluble components, those shown in Table 2 are used, and the solubility is evaluated by observing the appearance after adding these to the test sample, heating and dissolving at 80 ° C., and storing at 25 ° C. for 1 week. did. Table 3 shows the maximum concentration at which the poorly soluble component was dissolved.

From the results in Table 3, it was found that the erythritan derivative of the present invention is significantly superior in solubility of the poorly soluble component as compared with erythritan.

The cosmetics described below were prepared using the erythritan derivative of the present invention. All of the obtained cosmetics have an excellent usability, skin cosmetics have excellent moisturizing properties, makeup cosmetics have excellent luster and color development, and hair cosmetics have excellent finger passage and moisturization. It was something that could give a feeling.

Example 3 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 5.0 of Example 1
BG 4.0
Innocitol 0.5
Glycyrrhizinate 2K 0.01
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Na citrate Amount of pH 4.5 Amount of purified water 100 in total Part B Xanthan gum 0.05
BG 3.0
Purified water 20.0
Part C VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.1
Purified water 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A was heated to about 80 ° C. and dissolved uniformly. Part B was slowly added to part A with stirring, cooled to 40 ° C., and then part C was added to obtain a uniform liquid.

Example 4 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytopresome MEL (Nippon Fine Chemical Co., Ltd.) 3.0
DPG 3.0
Glycerin 1.0
Part B purified water 20.0
Part C Compound 5.0 of Example 1
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.5
Niacinamide 0.3
Betaine 1.0
Aloe extract 0.1
Bee wheat extract 0.1
Licorice extract 0.1
Hop extract 0.1
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed and slowly added to part B with stirring. Further, part C mixed in advance was added to obtain a uniform liquid.

Example 5 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 5.0 of Example 1
Diglycerin 3.0
Hydrolyzed hyaluronic acid 0.01
Arginine 0.05
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Betaine 0.5
Pullulan 0.5
Hydroxyethyl cellulose 0.03
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 Part B Hyaluronic acid Na 0.01
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 80 ° C. and mixed uniformly. Part B was added to prepare a uniform liquid.

Example 6 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 5.0 of Example 2
Diglycerin 3.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
PEG / PPG / Polybutylene Glycol-8 / 5/3 Glycerin 0.5
Glucosylceramide 0.5
Glucosylrutin 0.01
Polyquaternium-51 0.5
Acetyl Hexapeptide-8 0.001
Hydrolyzed collagen 0.05
Carbomer 0.05
Niacinamide 0.3
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Xanthan gum 0.1
Amount of purified water totaling 100 Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly dissolved at about 80 ° C., and part B was added to prepare a uniform liquid.

Example 7 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound of Example 1 10.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
PEG / PPG / Polybutylene Glycol-8 / 5/3 Glycerin 0.5
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.4
Xanthan gum 0.1
EDTA-2Na 0.05
Amount of purified water totaling 100 Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Chimpi extract 0.1
Licorice extract 0.1
Chaba extract 0.1
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly dissolved at about 80 ° C., and part B was added to prepare a uniform liquid.

Example 8 Toner
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound of Example 1 8.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
PEG-400 1.5
PEG-32 2.0
PPG-6 decyltetradeceth-30 0.2
PEG-60 hydrogenated castor oil 0.2
PEG-30 Phytosterol 0.1
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.2
Cocoyl hydrolyzed collagen K 0.5
Carbomer 0.05
Arginine 0.05
Phenoxyethanol 0.4
Hydroxyethyl cellulose 0.1
Amount of purified water totaling 100 Part B Hyaluronic acid Na 0.01
Oligohyaluronate Na 0.01
Momonoha extract 0.1
Scutellaria extract 0.1
Souhakuhi extract 0.1
Carrageenan 0.05
Citric acid 0.01
Na 0.05 citrate
Purified water 10.0
Part C Fragrance Appropriate amount Ethanol 3.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly dissolved at about 80 ° C., and parts B and C were added to prepare a uniform liquid.

Example 9 Toner
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phytocompo-SP (Nippon Fine Chemical Co., Ltd.) 1.0
Glycerin 10.0
DPG 5.0
BG 3.0
Compound 2.0 of Example 1
Part B Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.1
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.1
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 0.2
Squalene 0.3
Cetanol 0.3
Dimethicone 0.2
Part C dimethylparaben 0.1
Amount of water totaling 100 Part D Water 10.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 3.0
Carbomer 0.06
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer
0.06
Methylgluces-10 3.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part D was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part C was added and emulsified. After cooling, part D was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 10 Toner
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Compound 6.0 of Example 1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Diglycerin 2.0
Polyglyceryl laurate-10 0.3
Decama Macadamia Nut Fatty Acid Polyglyceryl-10 0.6
Betaine 1.0
Oil-soluble licorice extract 0.1
Part B Glycyrrhizinate 2K 0.1
Rosemary extract 0.1
Phenoxyethanol 0.4
Amount of purified water totaling 100 Part C Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were heated to obtain a uniform liquid. Part B was gradually added while stirring part A to obtain a uniform liquid. After cooling, part C was added to make it uniform.

Example 11 Toner
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Compound of Example 1 8.0
Glycerin 10.0
Xanthan gum 0.05
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.08
KOH 0.04
Cellulose gum 0.04
Amount of purified water totaling 100 Part B Plandol-LG3 (Nippon Fine Chemical Co., Ltd.) 0.1
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.1
Cetyl ethylhexanoate (Nippon Fine Chemical Co., Ltd.) 0.1
Cariodendron Orinosense Seed Oil 0.1
PEG-40 hydrogenated castor oil 0.1
Dimethicone 0.2
Stearyl glycyrrhetinate 0.05
Part C β-glucan 0.1
Phenoxyethanol 0.4
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were heated to obtain a uniform liquid. Part B was gradually added while stirring part A to obtain a uniform liquid. After cooling, part C was added to make it uniform.

Example 12 Gel lotion
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl behenate 0.8
Stearic acid 0.3
PEG-10 Dimethicone 0.4
Part B Compound 3.0 of Example 1
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexyl glycerin 0.2
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Hyaluronate Na 0.01
Hydroxyethyl acrylate / sodium acryloyl dimethyl taurine copolymer
0.15
Carbomer 0.06
Hydroxide K 0.05
Amount of purified water totaling 100 Part C Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 70 ° C. and dispersed uniformly. Part B was mixed, stirred well, made uniform, and then heated to about 70 ° C. Part B was added to part A, stirred at about 70 ° C. using a homomixer, cooled to about 40 ° C., and part C was added.

Example 13 All-in-one gel
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 5.0 of Example 1
Glycerin 3.0
PEG-4000 0.2
Methylgluces-10 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 0.5
Phenoxyethanol 0.3
Squalene 0.5
Dimethicone 20cs 0.5
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 0.3
Oil-soluble licorice extract 0.1
Ethylhexyl glycerin 0.2
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.1
Hyaluronic acid 0.05
Hydrolyzed hyaluronic acid 0.05
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 1.0
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Bilberry leaf extract 0.15
Amount of purified water totaling 100 parts B (dimethyltaurine ammonium acrylate / vinylpyrrolidone) copolymer
0.15
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.15
Arginine 0.25
Purified water 30.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was stirred to obtain a uniform liquid. Part B was mixed to obtain a viscous liquid. Part B was added to part A to make it uniform.

Example 14 Whitening emulsion
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-DP (Nippon Fine Chemical Co., Ltd.) 1.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Cetyl ethylhexanoate (Nippon Fine Chemical Co., Ltd.) 10.0
Cetanol 1.2
Phenyltrimethicone 3.0
Ethylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
Part B Stearoxy hydroxypropyl Methyl Cellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Pentylene glycol 3.0
Glycerin 8.0
Part D VC Ethyl (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 5.0
Part E Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 0.5
Compound 5.0 of Example 1
Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid 0.1
Amount of Na citrate pH of 4.5 Amount of purified water totaling 100 ---------------------------------------------------------------------------- −−−−−
(Preparation method)
Parts A and E were each heated to about 70 ° C. and dissolved uniformly. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and dispersed uniformly. After adding part A while stirring part C with a homodisper, part E was added while stirring. Parts D and B were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 15 Emulsion
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical Co., Ltd.) 1.0
LP70H (Nippon Fine Chemical Co., Ltd.) 0.1
Part B Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Setostearyl alcohol 1.0
Arachidyl alcohol 0.1
Jojoba Alcohol 3.0
Kimil alcohol 0.3
Ceraquil Alcohol 0.1
Hexildecanol 0.5
Part C Hydroxyethyl Acrylate / Acryloyl Dimethyl Taurine Na) Copolymer
0.2
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.03
Carbomer 0.1
Purified water 20.0
Part D Compound 5.0 of Example 1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
Polyquaternium-51 1.0
Niacinamide 0.2
Ascorbyl Glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 16 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 9.0
DPG 5.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Part B Vaseline 10.0
Pentaerythrityl tetraisostearate 5.0
Astaxanthin 0.01
Cetyl PG hydroxyethyl palmitamide 0.05
Dipentaerythrityl hexahydroxystearate 1.0
Part C carbomer 0.1
Hydroxide K 0.07
Xanthan gum 0.1
Purified water 10.0
Part D Compound of Example 1 8.0
Phenoxyethanol 0.4
Ethylhexyl glycerin 0.2
Methylparaben 0.05
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 17 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Squalene 10.0
Stearic acid 1.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 1.0
Macadamia nut oil 3.0
Hydrogenated rapeseed oil alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Acryloyldimethyltaurine ammonium /
Behenes Methacrylic Acid-25) Cross Polymer 0.2
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
Hydrolyzed polyγ-glutamic acid K 0.1
Na 0.1 polyglutamate
Oligopeptide-24 0.05
Part C Compound of Example 2 3.0
Glycyrrhizinate 2K 0.1
Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 18 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 1.0
Paraffin wax 3.0
Shea butter 3.0
Squalene 8.0
Cetanol 1.8
Hydrogenated cocoglyceryl 0.8
Glyceryl stearate 1.0
Behenyl alcohol 1.5
Sorbitan stearate 1.0
Methyl Glucose Sesquistearate 1.5
Part B xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Crystalline cellulose powder 0.3
Stearoxy hydroxypropyl methylcellulose 0.1
Purified water 20.0
Part C Compound of Example 1 8.0
Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 19 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 9.0
Phytocompo-C (Nippon Fine Chemical Co., Ltd.) 1.0
Glucosylrutin 0.001
Part B Argania Spinosa coconut oil 1.0
Theobroma Grange Florum Seed Fat 1.0
Astaxanthin 0.005
Diethylhexyl adipate (Nippon Fine Chemical Co., Ltd.) 0.5
Ethylhexyl palmitate 3.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 2.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Carnauba wax 0.5
Stairless-2 2.5
Stairless-21 1.8
Cetanol 3.0
Tocopherol acetate 0.03
Squalene 3.0
Part C carbomer 0.1
Arginine 0.1
Hydroxypropyl chitosan 0.2
Ethanol 3.0
Purified water 10.0
Panthenol 0.5
Retinol palmitate 0.05
Part D Compound 3.0 of Example 1
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 20 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 2.5
Part B Olive Fruit Oil 3.0
Olive oil 1.5
Shea fat 1.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 3.0
Sucrose stearate 0.8
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbyl tetrahexyldecanoate 7.0
Lauroyl sarcosine isopropyl 2.0
Oil-soluble licorice extract 0.5
Cetanol 2.5
Sorbitan stearate 0.8
Part C xanthan gum 0.05
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
Sodium metabisulfite 0.03
Arbutin (Nippon Fine Chemical Co., Ltd.) 1.0
Tranexamic acid (Nippon Fine Chemical Co., Ltd.) 1.0
Part D Compound 3.0 of Example 1
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Niacinamide 0.3
Propanediol 3.0
Turmeric root extract 0.1
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A, B, and D were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part C was mixed and stirred to give a viscous liquid. After adding part B while stirring part A with a homodisper, part D was added and emulsified. After cooling, part C was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 21 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A jojoba oil 2.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN DD-DHR (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.3
Propylene glycol stearate 0.6
Squalene 3.0
Behenyl alcohol 2.0
Ethylparaben 0.1
Liquid isoparaffin 0.5
Carnauba wax 0.3
Corn oil 0.3
Rapeseed oil 1.0
Sunflower oil 1.0
Wheat germ oil 1.0
Linseed oil 0.1
Cottonseed oil 0.1
Soybean oil 0.1
Shea fat 0.5
Stigmasterol 1.0
Stigma Stannole 1.0
Dihydrocholesterol 0.1
Lanosterol 0.1
Dihydrolanosterol 0.1
Cholesteryl nonanoate 0.1
Cholesteryl stearate 0.1
Cholesteryl isostearate 1.0
Cholesteryl oleate 0.1
Cholesteryl 12-hydroxystearate 0.1
Long-chain branched fatty acid cholesteryl 0.3
Octyldodecyl myristate 1.0
Octyldodecyl isostearate 1.0
Dimer dilinoleic acid hardened castor oil 1.0
Hydroxyalkyl dimer dilinoleyl ether 1.0
Tetra (hydroxystearic acid / isostearic acid)
Dipentaerythrityl 0.5
Rice bran oil fatty acid phytosteryl 0.5
Phenyltrimethicone 1.0
Diphenyldimethicone 1.0
Methyl Hydrogen Polysiloxane 1.0
Polyglyceryl-3 polydimethylsiloxyethyl dimethicone 0.5
Sugar-modified silicone 0.3
Polyoxyethylene / methylpolysiloxane copolymer 1.0
Tocopherol ferulate 0.1
Tocopherol phosphate 0.1
Tocotrienols 0.1
Tannin 0.01
Sesamin 0.01
Proanthocyanidins 0.01
Gravlysin 0.01
Grablen 0.01
Liquiritin 0.01
Isoliquilithin 0.01
Lactoferrin 0.01
Shogaol 0.01
Gingerol 0.01
Part B (acryloyldimethyltaurine / behenes methacrylate-25)
Copolymer 0.2
Crystalline cellulose 0.1
Gellan gum 0.1
Carboxyvinyl polymer 0.1
Hydroxide K 0.08
Purified water 20.0
Part C Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
Polyglyceryl laurate-10 0.5
Lysolecithin 0.05
Hydrogenated egg yolk lecithin 0.1
Glycerin 7.0
DPG 7.0
Part D Compound of Example 1 8.0
Citric acid 0.07
Appropriate amount of Na citrate EDTA-2Na 0.05
Pentetic acid 5Na 0.03
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was mixed and heated to about 70 ° C. to uniformly dissolve. Part B was mixed and stirred to give a viscous liquid. Part C was mixed, heated to about 70 ° C., and uniformly dispersed. Part D was mixed and heated to about 70 ° C. to uniformly dissolve. Part A was added to part C with stirring with a homogenizer, and then part D was added for emulsification. After cooling, part B was added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 22 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-G (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.5
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 7.0
Diisopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 2.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 1.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Bacil isostearate 2.0
Shea fat 3.0
Isostearyl pivalate 0.1
Ethylparaben 0.2
Stearyl alcohol 3.5
Cetanol 1.3
Polyglyceryl distearate-3 methyl glucose 0.8
Tocopherol 0.1
Ascorbyl tetrahexyl decanoate 8.0
Tocopheryl phosphate ascorbyl 2.0
Placenta extract 1.0
Oryzanol 0.3
Phytosphingosine 0.0001
Ubiquinone 0.03
Carotene 0.05
Lycopene 0.01
Astaxanthin 0.01
Lutein 0.01
Peanut oil 0.1
Rice bran oil 1.0
Hydrogenated castor oil 0.3
Jojoba oil 2.0
Orange roughy oil 1.0
Liquid lanolin (Nippon Fine Chemical Co., Ltd.) 1.0
Purified lanolin (Nippon Fine Chemical Co., Ltd.) 1.0
Polyoxyethylene lanolin 1.0
Lanolin Alcohol A (Nippon Fine Chemical Co., Ltd.) 0.3
Lanolin acetate alcohol 0.1
Cholesteryl acetate 0.1
Octocrylene 0.5
Sorbitan sesquistearate 1.2
Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed collagen 0.5
2-methacryloyloxyethyl phosphorylcholine
Butyl methacrylate copolymer solution 0.05
(HEMA Glucoside / Ethyltrimonium Methacrylate Trimonium Chloride) Copolymer 0.4
Glutathione 0.3
4- (4-Hydroxyphenyl) -2-butanol 1.5
Butyl resorcinol 1.5
Arbutin (Nippon Fine Chemical Co., Ltd.) 3.0
Ascorbyl Phosphate Mg 1.0
Part C Propanediol 10.0
Glycerin 7.0
Compound 3.0 of Example 1
Diglycerin 1.0
Sodium metabisulfite 0.1
Imidazolenium urea 0.1
Polyvinylpyrrolidone 0.1
Pullulan 0.1
Polyvinyl alcohol 0.1
Dehydroacetic acid 0.1
PEG-32 1.0
Polyglycerin 1.0
Pentetic acid 5Na 0.05
Appropriate amount of succinic acid and Na succinic acid Purified water Amount that totals 100 -----------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and dissolved uniformly. Part B was made uniform using a part of purified water. Part C was heated to about 70 ° C. and dispersed. While stirring with a homomixer at about 70 ° C., part A was gradually added to part C for emulsification, and after cooling to about 40 ° C., part B was added and mixed uniformly.

Example 23 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 1.0
Vegetable oil 10.0
Stearic acid 1.0
Moringa oil 3.0
Argania spinosa coconut oil 0.5
Hydrogenated rapeseed oil alcohol 2.0
Glyceryl stearate 1.0
Sorbitan sesquioleate 0.8
PEG-40 hydrogenated castor oil 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
Polyacrylate crosspolymer-11 0.2
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 1.0
Purified water 10.0
Palmitoyl tetrapeptide-7 0.05
Part C Compound of Example 1 15.0
PEG-8 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 24 Skin care cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Isohexadecane 12.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 3.0
Cetyl PEG / PPG-10 / 1 Dimethicone 2.0
(Behenic acid / icosane diacid) Glyceryl 0.5
Jojoba oil 0.5
Astaxanthin 0.01
Dipentaerythrityl tripolyhydroxystearate 1.0
Dimethicone 3.0
Part B Hydroxyethyl Cellulose 0.1
Purified water 10.0
Erythritol 0.5
Part C Compound of Example 1 15.0
Glycerin 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Mg chloride 0.3
Na chloride 0.7
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and C were mixed and heated to about 70 ° C. to uniformly dissolve and disperse them. Part B was mixed and stirred to give a viscous liquid. Part C was added while stirring with a homomixer to emulsify part A. After cooling, part B was added at about 50 ° C., and the mixture was stirred and cooled to about 40 ° C.

Example 25 Hand cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 8.0
YOFCO CLE-S (Nippon Fine Chemical Co., Ltd.) 5.0
LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.1
Squalene 8.0
Macadamia nut oil 0.5
Rosehip oil 1.0
Meadowfoam oil 1.0
Vaseline 15.0
Microcrystalline wax 2.0
Glyceryl stearate 5.0
Cetanol 2.0
Cetyl phosphate 1.0
Beeswax 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Compound 3.0 of Example 1
Glycerin 8.0
Propanediol 5.0
Methylparaben 0.1
Ethylhexyl glycerin 0.5
Phenoxyethanol 0.3
Na hydroxide 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 70 ° C. and dissolved. Part A was placed in another container and heated to about 80 ° C. to dissolve it. Part A was added to part B with stirring with a homomixer and emulsified. After emulsification, it was cooled to about 40 ° C.

Example 26 Hand cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Vaseline 5.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
(Dimethicone / Vinyl Dimethicone) Cross Polymer 0.3
(Vinyl Dimethicone / Lauryl Dimethicone) Cross Polymer 0.5
(Dimethicone / PEG-10 / 15) Crosspolymer 0.5
(PEG-15 / Lauryl Dimethicone) Cross Polymer 0.2
(Alkyl acrylate / dimethicone) copolymer 0.1
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 10.0
Propylparaben 0.1
Squalene 5.0
Part B Compound 3.0 of Example 1
Diglycerin 5.0
Methylparaben 0.1
Part C xanthan gum (2% aqueous solution) 10.0
(Acrylamide / Ammonium Acrylate) Copolymer 0.5
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
After dissolving part B, part A was added and heated to about 70 ° C. (part D). The temperature of part C was about 70 ° C. Part C was added to part D with stirring, and the mixture was stirred and mixed with a homomixer for about 3 minutes.

Example 27 Hand cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Squalene 10.0
Vaseline 20.0
Polyglyceryl pentastearate-10 2.0
Microcrystalline wax 4.0
Stearoyl Lactate Na 1.3
Al 1.5 stearate
Mg stearate 1.0
Ca 0.1 stearate
Part B LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 5.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-DP (Nippon Fine Chemical Co., Ltd.) 0.8
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 5.0
Diethylhexyl adipate (Nippon Fine Chemical Co., Ltd.) 6.0
Propylparaben 0.05
Tocopherol 0.05
Cyclopentasiloxane 5.0
Part C Compound of Example 2 8.0
Methylparaben 0.1
Glycerin 10.0
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Each of parts B and C was heated to about 80 ° C. and dissolved. Part A was placed in another container, heated to 100 to 120 ° C., transparent gelled, and cooled to 80 ° C. Part B was added to part A with stirring, and part C was further added for emulsification.

Example 28 Emulsion
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phytocompo-SP (Nippon Fine Chemical Co., Ltd.) 8.0
Hydrogenated lysolecithin (Nippon Fine Chemical Co., Ltd.) 0.1
Part B LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 5.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Squalene 4.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 4.0
α-olefin oligomer 2.5
Cyclopentasiloxane 3.5
Cetanol 1.5
Glyceryl stearate 1.0
Part C Compound of Example 2 3.0
Hydroxyproline 0.05
Citric acid 0.01
Na citrate 0.09
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.1
Amount of purified water totaling 100 Part D Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A to C were taken, heated to about 70 ° C., and mixed uniformly. Part B was gradually added to part A with stirring with a homodisper, and then part C was added at about 70 ° C. for emulsification. After cooling to about 40 ° C., the mixed part D was added and mixed uniformly.

Example 29 Cleansing gel
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 10.0
Plandoll-S (Nippon Fine Chemical Co., Ltd.) 1.0
Bell Paul DC-30 (Nippon Fine Chemical Co., Ltd.) 2.0
LUSPLAND DD-IS (Nippon Fine Chemical Co., Ltd.) 8.0
PEG-25 hydrogenated castor oil 20.0
Octildo Decess-20 15.0
Glycerin 16.0
BG 5.0
Part B Compound 3.0 of Example 1
Phenoxyethanol 0.5
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were each heated to about 80 ° C. and dissolved. It was mixed and heated to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 30 Cleansing cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Neosolue-DE (Nippon Fine Chemical Co., Ltd.) 2.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 3.0
Glycerin 3.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Celesin 6.0
Mineral oil 28.0
PEG-12 isostearate 3.0
Sorbitan sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Microcrystalline wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B Compound 3.0 of Example 1
DPG 5.0
Methylparaben 0.2
Edetonic acid 3Na 0.02
Phenoxyethanol 0.2
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were each heated to about 80 ° C. and dissolved. It was mixed and heated to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 31 Warm gel
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound of Example 1 10.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
PEG-40 hydrogenated castor oil 0.3
Vanillyl butyl 0.1
Togarashi tincture 0.5
Ginger tincture 0.5
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 2.0
Squalene 2.0
Part B Purified water Total amount of 100 Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.1
Xanthan gum 0.05
Carbomer 0.1
TEA 0.1
Methylparaben 0.2
Phenoxyethanol 0.2
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 60 ° C. and dissolved. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 32 Facial cleansing foam
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A stearic acid K 10.0
Palmitic acid K 10.0
Myristic acid K 10.0
Lauric acid K 4.0
Lauroyl sarcosine isopropyl 0.8
Neosolue-DiSM (Nippon Fine Chemical Co., Ltd.) 0.2
PEG1500 10.0
Glycerin 15.0
Glyceryl monostearate 1.0
POE (20) Sorbitan Monostearate 2.0
Part B Compound 5.0 of Example 1
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was heated to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C.

Example 33 Facial cleansing foam
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A (Palm Fatty Acid / Hydrogenated Beef Tallow Fatty Acid) Na Glutamic Acid 30.0
Cocoyl glycine K 5.0
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.2
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 0.1
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
PEG-32 10.0
Glycerin 14.0
Compound 4.0 of Example 1
Propylparaben 0.1
Part B Methylparaben 0.2
Polyquaternium-51 1.0
Crystalline cellulose 0.3
Polyquaternium-7 0.8
Amount of purified water totaling 100 Part C Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Heat part B to about 80 ° C. Part B was gradually added to part A with stirring, and after mixing, the mixture was cooled to 40 ° C. Part C was added and mixed uniformly.

Example 34 Body shampoo
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Palm fatty acid K, myristic acid K 10.0
Cocoyl methyl taurine Na 1.5
Cocamide DEA 5.0
EDTA-2Na 0.1
Concentrated glycerin 10.0
Compound 10.0 of Example 1
Cocamidopropyl Betaine 5.0
Phenoxyethanol 0.4
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated at about 80 ° C. and uniformly stirred and mixed.

Example 35 Body shampoo
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cocoyl Methyl Taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Na cocoamphoacetate (30%) 4.0
Cocamidopropyl Betaine (30%) 10.0
Olefin (C14-16) Na Sulfonate 5.0
Polyquaternium-10 1.3
Guar Hydroxypropyltrimonium Chloride 0.8
Acetyl hyaluronic acid Na 0.02
Cocamide DEA 3.0
Compound 1.0 of Example 1
Glycerin 5.0
Methylparaben 0.2
Amount of purified water totaling 100 Part B Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated at about 80 ° C. and uniformly stirred and mixed. The mixture was cooled to about 40 ° C., part B was added, and the mixture was uniformly mixed.

Example 36 Hand soap
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Cocoyl Icethionate Na 1.0
Glycerin 40.0
Compound 12.0 of Example 1
Part B lauroyl sarcosine salt 12.0
Myristoylation Methyl Taurine Sodium 2.0
Polyglyceryl laurate-6 2.0
Coconut oil fatty acid diethanolamide 2.0
PEG-7 coconut oil fatty acid glyceryl 2.0
Synthetic latex 0.1
Nitrocellulose 0.1
Sorbitol 8.0
Conchiolin Degrading Peptide 0.1
1,3-butylene glycol 8.0
Phenoxyethanol 0.8
Amount of purified water totaling 100 Part C Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Purified water 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 80 ° C. and dissolved. Part B was added to part A and heated to about 80 ° C. to uniformly dissolve. The mixture was cooled to about 40 ° C., and part C was added to make it uniform.

Example 37 Hair treatment that does not wash away
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Polyquaternium-37 2.0
Squalene 2.0
PPG-3 Caprilyl Ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Japan wax 0.2
Celesin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla low extract 0.1
Octyldodecyl erucate 4.5
Tocopherol acetate 0.02
Elcalactone MCT (Nippon Fine Chemical Co., Ltd.) 2.0
Dipentaerythrityl tripolyhydroxystearate 1.5
PPG-5 Phytosteryl 0.5
Compound 3.0 of Example 1
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed Conchiolin 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Amount totaling 100 Hydroxypropyl starch phosphoric acid 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part C was uniformly dispersed and heated to about 80 ° C. Next, part A was heated to about 80 ° C. to dissolve it. Part C was added while stirring, and after mixing uniformly, the mixture was cooled to about 40 ° C. Then, part B was added and mixed uniformly.

Example 38 Hair treatment that does not wash away
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 4.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Setrimonium chloride (25%) 2.8
Ranorin Row 1.0
Dimethicone (1 million cs) 1.0
PPG-3 Caprilyl Ether 1.0
Methyl heptyl myristate 0.5
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 0.3
Isononyl isononanoate 0.3
Tridecyl neopentate 0.5
Myristyl isooctanoate 0.3
Neopentyl glycol diethylhexanoate 0.3
Isobutyl isostearate 0.3
Glyceryl triisostearate 0.3
Trimethylolpropane triisostearate 0.3
Broccoli seed oil 0.3
Sphinganin 0.01
Glycerin 1.0
Part B Compound of Example 1 3.5
Methylparaben 0.1
Amount of purified water totaling 100 Phenoxyethanol 0.5
Part C NanoRepair-CMC5 (Nippon Fine Chemical Co., Ltd.) 5.0
NanoRepair-EL (Nippon Fine Chemical Co., Ltd.) 1.0
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Part D Carrageenan 0.1
Hydroxypropyl chitosan 0.05
Hydroxypropyl methylcellulose 0.1
Tuberose polysaccharide 0.1
Catified guar gum 0.05
Purified water 20.0
Part E Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.005
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80 ° C. and dissolved. Next, part A was heated to about 80 ° C. to dissolve it. Part D was dispersed to prepare a viscous liquid. Part A was added to part B with stirring, mixed uniformly, and then cooled to about 40 ° C. Then, parts C, D and E were added and mixed uniformly.

Example 39 Non-rinse scalp / hair treatment
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Mineral oil 3.0
Neosolue-Aquilio (Nippon Fine Chemical Co., Ltd.) 1.0
Ethanol 40.0
Glycyrrhetinic acid 0.02
PPG-3 Caprilyl Ether 0.3
Elcalactone DES (Nippon Fine Chemical Co., Ltd.) 1.5
PEG / PPG-20 / 20 Dimethicone 0.2
PEG-12 Dimethicone 0.4
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.2
Hydrogenated retinol 0.1
Trishexyldecanoic acid pyridoxine 0.05
Bisglyceryl ascorbic acid 0.3
Hexil 3-glyceryl ascorbic acid 0.3
Part B Compound 3.0 of Example 1
Triethanolamine 0.1
Amount of purified water totaling 100 (Acrylate / Alkyl acrylate (C10-30)) Crosspolymer 0.4
Carbomer 0.05
(Acryloyldimethyltaurine ammonium / VP) copolymer 0.05
(Acryloyldimethyltaurine ammonium / Behenez methacrylate-25) Crosspolymer 0.1
Hydroxypropyl chitosan 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Part C VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.05
Nicotinamide 0.3
Pyridoxine hydrochloride 0.1
Caffeine 0.1
Glucosyl trehalose 0.1
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 50 ° C. and dissolved. Next, part B was uniformly dispersed to obtain a viscous liquid. Part A was added to part B with stirring and mixed uniformly. Then part C was added and mixed uniformly.

Example 40 Hair Treatment
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Dodecane 1.5
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 0.2
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl ethylhexanoate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Setrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideces-6 0.3
BHT 0.03
Part B Compound 1.0 of Example 1
Methylparaben 0.2
Citric acid 0.05
Amount of purified water totaling 100 Part C PPG-3 myristyl 0.5
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 1.0
Part D Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.02
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80 ° C. and dissolved. Part A was added to another container, and the mixture was heated and dissolved. Part B was gradually added to part A and mixed uniformly. Parts C and D were added with stirring at about 50 ° C. to make them uniform.

Example 41 Hair treatment
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.5
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.2
Propanediol 3.0
Behenamide propyl dimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide MEA 0.8
Caesar Pineia Spinosa Hydroxypropyltrimonium Chloride 0.1
Rice bran wax 0.5
Glycerin 1.0
Compound 3.0 of Example 1
Part B Methylparaben 0.1
Lactic acid 0.4
Amount of purified water totaling 100 Part C Amodimethicone 3.0
Methyl heptyl caprylate 1.0
Polyquaternium-7 0.15
Myristic acid PPG-3 benzyl ether 0.5
Part D Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.005
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, parts C and D were added and mixed uniformly.

Example 42 Hair Treatment
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Dodecane 1.5
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 0.2
Candelilla wax 0.2
Cetyl Esters 0.3
Stearyl ethylhexanoate 1.0
Cetearyl alcohol 3.5
PEG-200 0.5
Hydroxyethyl cellulose 0.4
Setrimonium chloride (30%) 1.0
Behentrimonium chloride (80%) 1.0
Trideces-6 0.3
BHT 0.03
Part B Compound 1.0 of Example 1
Methylparaben 0.2
Citric acid 0.05
Amount of purified water totaling 100 Part C Dimethicone (3 million cs) 1.0
Dimethicone (100cs) 3.0
PPG-3 myristil 0.5
Isodecyl neopentane (Nippon Fine Chemical Co., Ltd.) 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80 ° C. and dissolved. Part A was added to another container, and the mixture was heated and dissolved. Part B was gradually added to part A and mixed uniformly. Part C was added with stirring at about 50 ° C. to make it uniform.

Example 43 Non-silicone hair treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 0.8
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Stearyl alcohol 2.0
Cetanol 1.2
Stealtrimonium chloride 1.0
PEG-45M 0.8
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.3
Totsubaki Seed Oil 0.4
Hydroxyethyl urea 0.5
Dicaprilyl Carbonate 2.0
PPG-1 / PEG-1 stearamine 1.0
Squalene 0.1
Isosetes-10 0.5
Sunflower wax 0.8
Cocoyl Arginine Ethyl PCA 0.2
Phenoxyethanol 0.2
Tocopherol 0.05
Part B Compound 5.0 of Example 1
DPG 2.2
Glycerin 1.3
Sorbitol 3.5
BG 1.0
Hydroxycellulose 0.07
Phenoxyethanol 0.2
Appropriate amount of citric acid EDTA-2Na 0.01
Amount of purified water totaling 100 Part C Polyquaternium-61 0.3
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part C was added and mixed uniformly.

Example 44 Shampoo
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Lauroylmethylalanine Na (30%) 13.0
Cocamidopropyl Betaine (30%) 20.0
Cocoyl Glutamic Acid TEA (30%) 5.0
Cocamide DEA 1.0
Glycerin 1.0
Glyceryl caprylate 0.4
Glyceryl undecylenate 0.1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Sorbitol 1.6
Polyquaternium-7 0.3
Part B Na benzoate 0.4
Na chloride 0.2
Amount of purified water totaling 100 Part C Swertia japonica extract 3.0
Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Polyquaternium-47 0.1
Purified water 9.7
Part D Compound 3.0 of Example 1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.01
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was placed in a separate container and heated to dissolve it. Part B was gradually added to part A, mixed uniformly, and part C was added at about 60 ° C. After cooling to about 40 ° C., part D was added and mixed uniformly.

Example 45 Shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A PPG-3 Caprilyl Ether 0.2
Ammonium Laureth Sulfate 5.0
Na laureth sulfate (25%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Lauric acid K 1.0
Glycol distearate 0.5
Toluene sulfonic acid 0.3
Stearoxypropyl dimethylamine 0.5
PPG-17 0.3
Dimethicone 0.1
PEG-9 Dimethicone 0.1
Amodimethicone 0.1
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 1.0
Neopentyl glycol diethylhexanoate 0.4
Lanolin fatty acid 0.3
Isodecyl glyceryl ether 0.4
Miconazole nitrate 0.75
Cocamide MEA 1.0
Laures-4 0.3
Laures-16 0.2
Stairless-6 0.2
Phenoxyethanol 0.3
Part B malic acid 0.1
Methylparaben 0.2
Phosphoric acid 0.03
Na benzoate 0.3
Amount of purified water totaling 100 Part C Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Purified water 6.7
Compound 5.0 of Example 2
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part C was added and mixed uniformly.

Example 46 Shampoo
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Compound 5.0 of Example 1
Cocoyl methyl taurine Na (30%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Glycol distearate 0.5
Naphthalene sulfonic acid 0.1
Isopropylmethylphenol 0.1
Stearoxypropyl dimethylamine 0.5
PEG-10 Dimethicone 0.3
Cocamidomethyl MEA 1.0
Coconut oil fatty acid PEG-7 glyceryl 0.5
Polyglyceryl diisostearate-2 0.3
PEG-50 lanolin 0.3
Phenoxyethanol 0.3
Part B malic acid 0.1
Phosphoric acid 0.03
Ca 0.2 propionate
Na benzoate 0.3
Amount of purified water totaling 100 Part C Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Amodimethicone 0.3
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 3.0
Purified water 6.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside separately, was heated to about 60 ° C. to make it uniform. Part B was gradually added to part A with stirring, mixed uniformly, and then cooled to about 50 ° C. Further, part C was added and mixed uniformly.

Example 47 Non-silicone shampoo
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.03
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.1
Compound 5.0 of Example 1
Laures-4 Na Carboxylic Acid (28%) 10.0
Laures-6 Carboxylic Acid 4.0
Cocamidopropyl Betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamidomethyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
Methylparaben 0.2
Phenoxyethanol 0.4
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated at about 80 ° C. and uniformly stirred and mixed.

Example 48 Leave on Hair Treatment
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 2.0
Setrimonium chloride (25%) 3.8
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
Phenoxyethanol 0.5
Part B Ethanol 5.0
Part C Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Amount of purified water totaling 100 Part D Compound of Example 1 1.0
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.005
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part C was heated to about 80 ° C. and dissolved. Next, part A was heated to about 80 ° C. to dissolve it. Part C was added while stirring, and after mixing uniformly, the mixture was cooled to about 40 ° C. Next, parts B and D were added and mixed uniformly.

Example 49 Moose
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Ethanol 5.0
Polyethylene glycol oleyl ether (20) 1.0
Acrylic resin alkanolamine solution 3.0
Diethylaminopropylamide stearate 0.5
Pyrrolidone carboxylic acid 0.2
Preservatives, fragrances 1.0
Amount of purified water totaling 100 Compound 2.0 of Example 1
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.005
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
The above components were mixed, and the obtained base and LPG were mixed at a ratio of base: LPG = 92: 8 to obtain an injection type mousse.

Example 50 Styling milk
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A LUSPLAN SR-DM4 (Nippon Fine Chemical Co., Ltd.) 1.0
Stearyl alcohol 1.7
Isopropyl palmitate (Nippon Fine Chemical Co., Ltd.) 1.2
Stearamidopropyl dimethylamine 1.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 0.2
Setes-20 0.3
Part B Compound 2.0 of Example 1
Phenoxyethanol 0.4
Lactic acid 0.4
Amount of purified water totaling 100 Part C Hydroxyethyl cellulose 0.4
BG 2.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A and B were mixed at about 80 ° C., respectively. Part B was added to part A for emulsification, cooled to about 60 ° C., and then part C was added.

Example 51 Hair Color Treatment
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Neosolue-Aqualio (Nippon Fine Chemical Co., Ltd.) 1.0
Stealtrimonium chloride (70%) 2.5
Cationic NH (Nippon Fine Chemical Co., Ltd.) 0.3
Cocamide DEA 1.0
Inulin stearate 0.5
Lanolin alcohol 0.2
Montan wax 0.1
Polyethylene wax 0.1
Beeswax 0.1
Dextrin palmitate 0.3
Celesin 0.1
Capric acid PPG-3 1.0
Dicapric acid PG 1.0
Ethylhexyl ethylhexanoate 1.0
Dicaprilyl Carbonate 1.5
Glycerin 4.0
Setes-7 1.0
Isostearyl alcohol 0.3
Rice bran oil 0.5
Glyceryl stearate 0.5
Elcalactone DES (Nippon Fine Chemical Co., Ltd.) 1.5
Hydrogenated polydecene 0.1
Macadamia nut fatty acid ethyl 1.0
Lysine dilauroyl glutamate Na 0.1
Behendimonium stearyl ethyl phosphate 0.1
Tocopherol 0.05
Phenoxyethanol 0.3
Part B Compound 2.0 of Example 1
Purified water 10.0
BG 2.0
Acylated hydrolyzed collagen 0.1
Panthenol 0.1
Hydroxyethyl cellulose 0.1
Polyquaternium-64 0.1
Polyquaternium-51 0.01
Polyquaternium-49 0.2
Phenoxyethanol 0.4
PCA-Na 0.1
Part C Purified water Amount totaling 100 Basic blue 99 0.1
Basic tea 16 0.13
HC Blue 2 0.05
HC Yellow 2 0.03
HC Red 3 0.1
Hydroxyethyl urea 0.5
Arginine 0.2
Ammonium hydrogen carbonate 1.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was heated to about 80 ° C. to dissolve it. Part C was heated to about 80 ° C. in another container to dissolve it. While stirring part C in part A, it was gradually added and mixed uniformly, and then rapidly cooled (part D). Part B was added to part D at about 40 ° C. to make it uniform.

Example 52 Hair Manicure
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Ethanol 10.0
Carnauba wax 0.01
Setes-10 1.0
Elcalactone DES (Nippon Fine Chemical Co., Ltd.) 2.5
PPG-3 Caprilyl Ether 1.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 1.0
Decanoate PPG-3 0.5
Dicapric acid PG 0.5
Dicaprilyl Carbonate 0.5
Part B Purple 401 0.2
Black 401 0.1
Orange 205 0.1
Red 102 0.1
Citric acid 2.0
Benzyl alcohol 8.0
Ethanol 10.0
Part C Purified water Amount totaling 100 Compound 1.0 of Example 1
(Acryloyldimethyltaurine ammonium / VP) copolymer 3.0
Glycolic acid 2.0
Xanthan gum 0.2
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A and C were mixed and made uniform. Part B was added to part C with stirring and mixed uniformly, and then part A was added at about 60 ° C. and mixed uniformly.

Example 53 Water-containing gloss
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Octildodecanol 27.0
Ethyl cellulose 2.5
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 10.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 2.0
LUSPLAND DD-DHR (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 0.1
Dimethylsilylated silica 0.2
Inulin stearate 0.3
PEG-60 hydrogenated castor oil 1.0
Red No. 202 Appropriate amount Yellow No. 4 Appropriate amount Titanium oxide Appropriate amount Sorbitan stearate, coconut fatty acid sucrose mixture (ALACEL2121 manufactured by Croda Co., Ltd.) 3.0
Part B Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.4
Maltose 2.0
Phenoxyethanol 0.2
Compound 2.0 of Example 1
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Parts A and B were each heated and dissolved, part B was added to part A, mixed, and then cooled to about 40 ° C.

Example 54 Water-containing gloss
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Octildodecanol 27.0
Ethyl cellulose 2.5
Hydrogenated polyisobutene 10.0
Diethylhexyl sebacate (Nippon Fine Chemical Co., Ltd.) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical Co., Ltd.) 2.0
LUSPLAN SR-DP4 (Nippon Fine Chemical Co., Ltd.) 2.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-SUN (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 0.1
YOFCO MAC (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG2 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG3 (Nippon Fine Chemical Co., Ltd.) 0.1
Plandoll-LG4 (Nippon Fine Chemical Co., Ltd.) 0.1
Dimethylsilylated silica 0.5
Dextrin palmitate 0.1
PEG-60 hydrogenated castor oil 1.0
Red No. 202 Appropriate amount Red No. 218 Appropriate amount Red No. 223 Appropriate amount Orange No. 201 Appropriate amount Sorbitan stearate, coconut fatty acid sucrose mixture (ALACEL2121 manufactured by Crowder Co., Ltd.) 3.0
Part B Compound 2.0 of Example 1
Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.4
Maltose 2.0
Phenoxyethanol 0.2
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A and part B were heated and melted to make them uniform, and part B was mixed with part A.

Example 55 Lip Tint
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 2.0 of Example 1
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Diisopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 3.0
Diisobutyl adipate (Nippon Fine Chemical Co., Ltd.) 3.0
Diethylhexyl succinate (Nippon Fine Chemical Co., Ltd.) 3.0
Neosolue-Aquolio (Nippon Fine Chemical Co., Ltd.) 2.0
Ethanol 2.0
Red 218 0.1
Red No. 223 0.1
Orange 201 0.1
Dehydroacetic acid 0.1
Part B LUSPLAN SR-DP4 (Nippon Fine Chemical Co., Ltd.) 10.0
LUSPLAN PI-DA (Nippon Fine Chemical) A total amount of 100 Trioctanoin (Nippon Fine Chemical) 6.0
Hydrogenated polyisobutene 40.0
Octyldodecanol 10.0
Tocopherol 0.1
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A and B were heated and melted to make them uniform, and part A was mixed with part B.

Example 56 Lipstick
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Compound 12.0 of Example 1
Glycerin (Nippon Fine Chemical Co., Ltd.) 8.0
Arbutin (Nippon Fine Chemical Co., Ltd.) 2.0
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
PEG-20 glyceryl isostearate 1.0
Betaine 1.0
Glucosyl trehalose 0.5
Methylparaben 0.1
Part B Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 3.0
Trioctanoin (Nippon Fine Chemical Co., Ltd.) A total amount of 100 PM wax 82 (Nikko Rika) 8.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Tocopherol 0.1
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A and B were heated and melted to make them uniform, and part A was mixed with part B.

Example 57 Liquid Foundation
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Plandoll-G (Nippon Fine Chemical Co., Ltd.) 5.0
Glyceryl stearate (SE) 1.0
Stearate PG (SE) 1.0
Tocopherol 0.1
Propylparaben 1.0
Part B Titanium oxide / iron oxide mixture (FDP-W-007 manufactured by Toiro Pigment Co., Ltd.) 18.0
Mica 7.0
BG 5.0
Compound 2.0 of Example 1
Methylparaben 0.2
Amount of purified water totaling 100 Part C Cellulose gum (2% aqueous dispersion) 5.0
Xanthan gum (2% aqueous dispersion) 5.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
A part, B part and C part were heated and mixed. After adding part B to part A and emulsifying, the mixture was cooled to about 50 ° C., part C was added, and the mixture was stirred until uniform.

Example 58 Liquid Foundation
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Purified water Amount totaling 100 Compound 3.0 of Example 1
Carboxyvinyl polymer 0.1
Potassium hydroxide Appropriate amount DPG 5.0
Preservative Appropriate amount B part Polyoxyethylene modified dimethylpolysiloxane 1.0
Trimethylsiloxysilicic acid 3.0
Phenylmethicone 1.0
Cyclomethicone 9.0
Part C Zinc Oxide 10.0
Sericite 0.36
Titanium oxide 8.32
Iron oxide yellow 0.8
Iron oxide red 0.36
Iron oxide black 0.16
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
After heating and stirring Part A at 70 ° C., Part C was added and dispersed. This was preheated to 70 ° C. and added to part B for emulsification and dispersion. It was cooled to about 40 ° C. and mixed uniformly.

Example 59 Foundation
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Hydrogenated polyisobutene 5.0
Cyclopentasiloxane 4.0
Mineral oil 4.0
Ethylhexyl methoxycinnamate 3.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Vaseline 1.0
Phenyltrimethicone 2.0
Sorbitan isostearate 1.5
Tribehenin 0.5
(Butyl acrylate / glycol dimethacrylate) Crosspolymer,
Silica, (Methyl Methacrylate / Glycol Dimethacrylate)
Crosspolymer mixture 2.0
Boron Nitride 1.0
PEG / PPG-19 / 19 Dimethicone,
Cyclopentasiloxane mixture 4.0
Gistear dimonium hectorite (20%) 2.5
Polypropyl sesquioxane,
Cyclopentasiloxane mixture 1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium oxide 10.0
Iron oxide 1.5
Part B Water Total amount of 100 DPG 4.0
Maltitol (75% solution) 1.0
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.4
Na Chloride 1.0
BG 1.0
Na hyaluronate (1% solution) 0.1
Phenoxyethanol 0.3
Compound 5.0 of Example 1
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to about 70 ° C., stirred well and dispersed uniformly. Part B was heated to about 70 ° C. to make it uniform, and then part B was added to part A, emulsified with stirring at about 70 ° C., and cooled to about 40 ° C.

Example 60 Base cream
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A LUSPLAN DD-DA7 (Nippon Fine Chemical Co., Ltd.) 5.0
Argania spinosa coconut oil 0.1
Cyclomethicone 14.0
Trimethylsiloxysilicic acid 3.0
Glyceryl stearate (SE) 2.0
Stearate PG (SE) 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 0.5
Stearic acid 0.5
Palmitic acid 0.5
Ethylhexyl methoxycinnamate 0.5
Tocopherol 0.2
Part B BG 10.0
Ethanol 1.0
Mica 8.0
Talc 7.0
Phenoxyethanol 0.8
Compound 2.0 of Example 1
Titanic acid (Li / cobalt) 0.2
Amount of purified water totaling 100 Part C Dextrin (1%) 1.0
Xanthan gum (10%) 1.0
Cellulose gum (10%) 1.0
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Parts A and B were heated and dissolved in separate containers. Part B was added to part A and emulsified, then part C was added and mixed uniformly. After stirring, the mixture was cooled to 40 ° C.

Example 61 Sunscreen cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Quotanium-18 Hectorite 1.0
Part B Cyclomethicone 13.7
Diphenyldimethicone 2.0
Cyclopentasiloxane 10.0
Plandoll-H (Nippon Fine Chemical Co., Ltd.) 1.0
Plandoll-G (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 2.0
Dicaprilyl Carbonate 1.0
Dimethicone Copolypoly 5.5
Part C Silicone treated fine particles Titanium oxide 3.9
Silicone treated zinc oxide 2.1
Part D Stearate Al 0.7
Al 0.5 hydroxide
Isononyl isononanoate 2.5
Neosolue-MP (Nippon Fine Chemical Co., Ltd.) 1.0
Neosolue-DE (Nippon Fine Chemical Co., Ltd.) 1.0
Part E trimethylsiloxysilicic acid 1.2
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.0
Tocopherol 0.02
Part F Compound 7.0 of Example 1
Na Chloride 1.0
Methylparaben 0.15
Amount of purified water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was added to part B and stirred. Further C was added and dispersed using a roller mill. Part D was heated and melted, and part E was added to the mixture of parts A, B, and C to bring the temperature to about 70 ° C. Part F was warmed and gradually emulsified into a mixture of parts A to E with stirring.

Example 62 Sunscreen Cosmetics
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl salicylate 4.0
Diethylaminohydroxybenzoyl hexyl benzoate 2.25
t-Butylmethoxydibenzoylmethane 1.0
Neosolue-EHS (Nippon Fine Chemical Co., Ltd.) 3.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical Co., Ltd.) 2.0
Diisopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 1.0
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 1.0
Compound 3.0 of Example 1
Methylparaben Appropriate amount Water Amount that totals 100 Part D Carbomer (2%) 5.0
Water-dispersed titanium oxide 5.0
Tremoist-TP (Nippon Fine Chemical Co., Ltd.) 0.1
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly dispersed. Parts B and C were each heated and dissolved at about 70 ° C. After gradually adding the B part to the A part, the C part was gradually added and emulsified. The mixture was cooled with stirring, and part D was added at 45 ° C. and stirred.

Example 63 Sunscreen Cosmetics
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Phytocompo-PP (Nippon Fine Chemical Co., Ltd.) 1.0
BG 10.0
Glycerin 9.0
Part B Ethylhexyl methoxycinnamate 7.0
Diethylaminohydroxybenzoyl hexyl benzoate 7.0
Behenyl alcohol 4.0
Neosole-DiSM (Nippon Fine Chemical Co., Ltd.) 0.5
Plandoll-LG1 (Nippon Fine Chemical Co., Ltd.) 0.2
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Part C Compound 3.0 of Example 1
Methylparaben 0.15
Amount of purified water totaling 100 Part D Xanthan gum 0.2
Hyaluronate Na 0.01
Purified water 10.0
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
(Preparation method)
Part A was uniformly dispersed. Parts B and C were each heated and dissolved at about 70 ° C. After gradually adding the B part to the A part, the C part was gradually added and emulsified. After cooling with stirring, parts D and E were added at 45 ° C., and the mixture was uniformly mixed.

Example 64 Two-phase sunscreen cosmetics
Composition amount (% by weight)
－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－－
Part A Diisopropyl sebacate (Nippon Fine Chemical Co., Ltd.) 5.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical Co., Ltd.) 5.0
Plandoll-MAS (Nippon Fine Chemical Co., Ltd.) 1.0
Part B (Dimethicone / Vinyl Dimethicone) Cross Polymer 5.0
(Vinyl Dimethicone / Meticone Silsesquioxane) Cross Polymer 5.0
Zinc oxide, hydrous silica, hydrogen dimethicone 5.0
Part C Cyclomethicone A total amount of 100 isododecane 10.0
Ubinal A + B (manufactured by BASF) 10.0
Ethylhexyl methoxycinnamate 3.0
Octocrylene 1.0
Cetyldiglyceryltris (trimethylsiloxy) Cyrilethyldimethicone 1.0
Bisethylhexyloxyphenol methoxyphenyl triazine 1.0
PEG / PPG-19 / 19 Dimethicone, Cyclomethicone Mixture 0.25
Part D Compound 7.0 of Example 1
Ethanol 10.0
Glycerin 3.0
Tremoist-SL (Nippon Fine Chemical Co., Ltd.) 0.5
VC Ethyl (Nippon Fine Chemical Co., Ltd.) 0.5
Citric acid 0.02
Na citrate 0.8
Purified water 10.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A is dissolved at 80 ° C. Part B was added to part A, and the mixture was dispersed and mixed. Part C was dissolved at 80 ° C. and mixed with Part B. Part D was heated and thawed and added to the mixture of part C for emulsification.

Example 65 Skin Care Oil
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Macadamia nut oil 24.0
Squalene 24.0
Neosolue-MCT (Nippon Fine Chemical Co., Ltd.) 10.0
Plandoll-ISS (Nippon Fine Chemical Co., Ltd.) 2.0
Tocopherol 0.1
Part B Compound 2.0 of Example 1
Neosolue-AquaS (Nippon Fine Chemical Co., Ltd.) 0.5
NaCl 0.1
Methylparaben 0.1
Phenoxyethanol 0.4
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was heated to 50 ° C., melted uniformly, and cooled to room temperature. Part B was heated to 80 ° C., melted uniformly, and cooled to about 40 ° C. A part and B part were mixed.

Example 66 Oil Drop Dispersion Toner
Composition amount (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A YOFCO CLC-678 (Nippon Fine Chemical Co., Ltd.) 1.0
Part B Gellan gum 0.1
Glycerin 2.0
BG 5.0
Compound 5.0 of Example 1
Methylparaben 0.1
Phenoxyethanol 0.3
Amount of water totaling 100 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 80 ° C. and dissolved uniformly. Part A was added and cooled to about 40 ° C. with stirring.

In the above formulation, the details of the ingredients described by the product names are as follows.

〇LUS PLAN DD-IS: Dimer dilinoleyl diisostearate 〇LUS PLAN PI-DA: Dimer dilinoleate di (isostearyl / phytosteryl)
〇LUSPLAN DD-DHR: Dimerge linoleyl hydrogenated rosin condensate 〇LUSPLAN DD-DA7: Dimerge linoleic acid Dimerge linoleyl 〇LUSPLAN SR-DP4: Dimerge linoleic acid Dimerge linoleyl, pentaerythrityl tetraisostearate 〇LUS PLAN SR-DM4: Dimaryllinoleic acid Dimagelinoleyl, tri (caprylic acid / capric acid) glyceryl 〇NanoRepair-CMC5: Contains ceramide 1, ceramide 2, ceramide 3, ceramide 5, ceramide 6, cholesterol, quaternium-33 Composition 〇NanoRepair-EL: γ-docosalactone, soybeansterol-containing composition 〇Neosolue-Aquilo: Cyclohexanedicarboxylic acid bisethoxydiglycol 〇Neosolue-AquaS: Eikosandioic acid / tetradecanoic acid) Polyglyceryl-10
〇 Neosolue-MCT: Tri (caprylic acid / capric acid) glyceryl 〇 Neosolue-MP: Methylpentanediol dineosonate 〇 Neosolue-DE: Diethylpentanediol dineosonate 〇 Neosolue-DiSM: Diisostearyl malate (methyl branched type)
〇Plandol-ISS: Phytosteryl isostearate 〇Plandol-SUN: Sunflower seed oil fatty acid phytosteryl 〇Plandol-MAS: Macadamia nut oil fatty acid phytosteryl 〇Plandol-LG1: Di (phytosteryl / octyldodecyl) lauroyl glutamate
〇Plandol-LG2: Di-lauroyl glutamate (phytosteryl / octyldodecyl)
〇Plandol-LG3: Di-lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
〇Plandol-LG4: Di lauroyl glutamate (phytosteryl / octyldodecyl / behenyl)
〇Plandol-DP: Bisdiglyceryl polyacyl adipate-2
〇Plandol-G: Dimer dilinoleyl bis (behenyl / isostearyl / phytosteryl)
〇Plandol-H: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Plandol-S: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
〇Phytopresome MEL: Glycolipid, hydrogenated lecithin, BG, purified water 〇Phytocompo-SP: hydrogenated lecithin, phytosterols, BG, glycerin 〇Phytocompo-PP: hydrogenated lecithin, phytosterols 〇Phytocompo-C: hydrogenated recithin Phytosterols, ceramide 2, ceramide 3, ceramide 6II
〇 Tremoist-TP: White jellyfish polysaccharide 〇 Tremoist-SL: White jellyfish polysaccharide, water, phenoxyethanol 〇 VC ethyl: 3-O-ethylascorbic acid 〇 YOFCO MAC: Macademia nut oil fatty acid cholesteryl 〇 YOFCO CLC-678: dihydrocholesteryl oleate Cholesteryl nonanoate, dihydrocholesteryl butyrate, cholesteryl butyrate, phytosteryl oleate 〇YOFCO CLE-S: lanolin fatty acid cholesteryl 〇elcalactone DES: γ-docosalactone, diethyl sebacate 〇elcalactone MCT: γ-docosalactone, tri (caprylic acid) / Caprylic acid) Glyceryl 〇Belpol DC-30: Dihydrocholes-30
〇Cation NH: Quotanium-33

Claims (3)

An erythritan derivative represented by the following general formula (1).

(In the formula, R1 and R2 represent hydrocarbon groups or hydrogen atoms having 1 to 4 carbon atoms, which may be the same or different, respectively. However, R1 and R2 do not become hydrogen atoms at the same time.) An erythritan derivative represented by the following general formula (2).

A cosmetic containing the erythritan derivative according to claim 1 or 2.