CN101642449B - Skin mucous membrane disinfectants and preparation method thereof - Google Patents
Skin mucous membrane disinfectants and preparation method thereof Download PDFInfo
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- CN101642449B CN101642449B CN2009101643712A CN200910164371A CN101642449B CN 101642449 B CN101642449 B CN 101642449B CN 2009101643712 A CN2009101643712 A CN 2009101643712A CN 200910164371 A CN200910164371 A CN 200910164371A CN 101642449 B CN101642449 B CN 101642449B
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Abstract
The invention provides various skin mucous membrane disinfectants which are prepared by adopting double-chain quaternary ammonium salt and benzalkonium bromide (C20H40BrN) as main germicidal ingredients and using triclosan (C12H7Cl3O2), polyethylene glycol (HOCH2(CH2OCH2)nCH2OH), glycerol (C3H8O3), Tween 80, menthol, borneol, medical alcohol and the like as adjuvant ingredients, can be used in the fields such as the disinfection of skin and mucosa, the disinfection of surgical hand washing and the disinfection of medical apparatus and instruments in the hospital, the disinfection of tools anddevices in public places and different production industries, the mold prevention of industrial products and agricultural grains, the health disinfection of poultry houses, the aquatic product field,the aquaculture, the killing of alga, the preparation of plastic antibacterial agent, the preparation of compound disinfectant and the like and has effective bactericidal action to staphylococcus aureus, colibacillus, candida albicans, HIV and the like ; in addition, the preparation method is simple and the production cost is lower.
Description
Technical field
The present invention relates to the disinfectant solution field, particularly a kind of skin mucous membrane disinfectants and preparation method thereof of external.
Background technology
Existing a lot of disinfectant solution kind on the market is numerous; What hospital was the most frequently used is to adopt medical alcohol that skin, medical apparatus and instruments are carried out disinfection; But the use field of medical alcohol is still very limited, and Disinfection Effect neither be best, adopts the disinfectant solution of configurations such as Polyethylene Glycol, glycerin in addition; The Disinfection Effect of the disinfectant solution of this type still is not very desirable, and carries out disinfection or certain zest is arranged mucocutaneous.
So need a kind of Disinfection Effect good now, non-irritating again disinfectant solution.
Summary of the invention
The present invention is for addressing the above problem; A kind of skin mucous membrane disinfectants is provided; Can be applied to skin, mucosa sterilization, effectively staphylococcus aureus, escherichia coli, candida albicans, HIV etc. played killing action, reach strict sterilization requirement; And, can also be applied to various medical apparatus sterilizings to mucocutaneous non-stimulated.
A kind of skin mucous membrane disinfectants is characterized in that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2-0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chloride 0.1-0.3%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is: at first two decyl alkyl dimethyl ammonium chlorides of two decyl dimethyl ammonium bromide of 0.2-0.5%, 0.1-0.3% are added ionized water and be dissolved in the agitated reactor, be stirred to solution; Be heated to 20-50 ℃ then and stirred 2-4 hour, left standstill then 24-28 hour, filter fill, make finished product.
Said disinfectant solution, can compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2-0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chloride 0.1-0.3%,
Benzalkonium bromide 0.15-0.4%,
Trichloro hydroxyl diphenyl ether 0.15-0.4%,
Mentholum 0.2-0.4%,
Borneolum Syntheticum 0.2-0.4%,
Medical alcohol 10-30%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the benzalkonium bromide of the two decyl alkyl dimethyl ammonium chlorides of two decyl dimethyl ammonium bromide of 0.2-0.5%, 0.1-0.3% and 0.15-0.4% is added ionized water be dissolved in the agitated reactor, be stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15-0.4%, the Mentholum of 0.2-0.4%, the Borneolum Syntheticum of 0.2-0.4%, the medical alcohol mixing stirring and dissolving of 10-30% become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Said disinfectant solution, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2-0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chloride 0.1-0.3%,
Benzalkonium bromide 0.15-0.4%,
Trichloro hydroxyl diphenyl ether 0.15-0.4%,
Polyethylene Glycol 0.2-0.6%,
Glycerin 0.4-0.8%,
Tween 80 0.2-0.6%,
Mentholum 0.2-0.4%,
Borneolum Syntheticum 0.2-0.4%,
Medical alcohol 10-30%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the Tween 80 of the glycerin of the benzalkonium bromide of two decyl alkyl dimethyl ammonium chlorides of two decyl dimethyl ammonium bromide of 0.2-0.5%, 0.1-0.3%, 0.15-0.4%, 0.4-0.8% and 0.2-0.6% is added ionized water be dissolved in the agitated reactor, be stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15-0.4%, the Polyethylene Glycol of 0.2-0.6%, the Mentholum of 0.2-0.4%, the Borneolum Syntheticum of 0.2-0.4%, the medical alcohol mixing stirring and dissolving of 10-30% become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Through adopting double-chain quaternary ammonium salt and benzalkonium bromide (C
20H
40BrN) be main sterilization component all, be aided with trichloro hydroxyl diphenyl ether (C
12H
7Cl
3O
2), Polyethylene Glycol (HOCH
2(CH
2OCH
2) nCH
2OH), glycerin (C
3H
8O
3), the various skin mucous membrane disinfectants processed such as Tween 80, Mentholum, Borneolum Syntheticum, medical alcohol, all have the disinfectant effect.
This disinfectant solution detects through sterilization inspection center of Academy of Military Medicine, PLA, and the detection conclusion of examining report bianhao 200931 is:
1, chmice acute per os poison test: per os LD
20＞5000mg/Kg body weight, the true border of toxicity grading is nontoxic;
2, mouse bone marrow cells is had a liking for the institute's cell micronucleus that incarnadines test: PCEMNR is not had the micronucleus of causing effect;
3, acute eye irritation test: acute eye irritation score index is up to 0, and stimulus intensity belongs to nonirritant;
4, damaged skin irritant test: the total mark meansigma methods is 0, skin irritation index＜0.5, and stimulus intensity belongs to nonirritant;
5, vaginal mucomembranous irritant test: to rabbit vagina MMi index is 0.778, and stimulus intensity belongs to nonirritant.
Beneficial effect of the present invention is following:
This disinfectant solution can be widely used in hospital's skin, mucosa sterilization; Surgical hand sterilization and medical apparatus sterilizing; Also can be used for public place and the apparatus of each production industry and the sterilization of equipment; And the mildew-resistant of industrial products and agriculture corn; Fields such as the disinfecting of pouity dwelling place, Aquatic product, breed, algae are killed, plastic antimicrobial agent prepares, compound disinfectant preparation, and can play effective killing action to staphylococcus aureus, escherichia coli, candida albicans, HIV etc.; And the method for preparing of this disinfectant solution is also simple, and production cost is lower.
The specific embodiment
Embodiment 1
A kind of skin mucous membrane disinfectants is characterized in that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.1%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is: at first two decyl dimethyl ammonium bromide of 0.2%, two decyl alkyl dimethyl ammonium chlorides of 0.1 are added ionized water and be dissolved in the agitated reactor, be stirred to solution; Be heated to 20-50 ℃ then and stirred 2-4 hour, left standstill then 24-28 hour, filter fill, make finished product.
Embodiment 2
A kind of skin mucous membrane disinfectants is characterized in that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.1%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is: at first two decyl dimethyl ammonium bromide of 0.5%, two decyl alkyl dimethyl ammonium chlorides of 0.1% are added ionized water and be dissolved in the agitated reactor, be stirred to solution; Be heated to 25-45 ℃ then and stirred 2-4 hour, left standstill then 24-28 hour, filter fill, make finished product.
Embodiment 3
A kind of skin mucous membrane disinfectants is characterized in that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.3%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.2%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is: at first two decyl dimethyl ammonium bromide of 0.3%, two decyl alkyl dimethyl ammonium chlorides of 0.2% are added ionized water and be dissolved in the agitated reactor, be stirred to solution; Be heated to 30-40 ℃ then and stirred 2-4 hour, left standstill then 24-28 hour, filter fill, make finished product.
Embodiment 4
A kind of skin mucous membrane disinfectants is characterized in that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.25%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.35%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is: at first two decyl dimethyl ammonium bromide of 0.25%, two decyl alkyl dimethyl ammonium chlorides of 0.35% are added ionized water and be dissolved in the agitated reactor, be stirred to solution; Be heated to 20-40 ℃ then and stirred 2-4 hour, left standstill then 24-28 hour, filter fill, make finished product.
Embodiment 5
A kind of skin mucous membrane disinfectants, can compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.15%,
Benzalkonium bromide 0.2%,
Trichloro hydroxyl diphenyl ether 0.15%,
Mentholum 0.4%,
Borneolum Syntheticum 0.25%,
Medical alcohol 15%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.2%, two decyl alkyl dimethyl ammonium chlorides of 0.15% and 0.2% benzalkonium bromide add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15%, 0.4% Mentholum, 0.25% Borneolum Syntheticum, 15% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 6
A kind of skin mucous membrane disinfectants, can compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.4%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.1%,
Benzalkonium bromide 0.25%,
Trichloro hydroxyl diphenyl ether 0.25%,
Mentholum 0.25%,
Borneolum Syntheticum 0.35%,
Medical alcohol 20%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.4%, two decyl alkyl dimethyl ammonium chlorides of 0.1% and 0.25% benzalkonium bromide add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.25%, 0.25% Mentholum, 0.35% Borneolum Syntheticum, 20% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 7
A kind of skin mucous membrane disinfectants, can compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.35%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.25%,
Benzalkonium bromide 0.35%,
Trichloro hydroxyl diphenyl ether 0.3%,
Mentholum 0.4%,
Borneolum Syntheticum 0.25%,
Medical alcohol 30%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.35%, two decyl alkyl dimethyl ammonium chlorides of 0.25% and 0.35% benzalkonium bromide add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.3%, 0.4% Mentholum, 0.25% Borneolum Syntheticum, 30% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 8
A kind of skin mucous membrane disinfectants, can compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.25%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.3%,
Benzalkonium bromide 0.4%,
Trichloro hydroxyl diphenyl ether 0.4%,
Mentholum 0.2%,
Borneolum Syntheticum 0.4%,
Medical alcohol 25%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.25%, two decyl alkyl dimethyl ammonium chlorides of 0.3% and 0.4% benzalkonium bromide add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.4%, 0.2% Mentholum, 0.4% Borneolum Syntheticum, 25% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 9
A kind of skin mucous membrane disinfectants, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.15%,
Benzalkonium bromide 0.25%,
Trichloro hydroxyl diphenyl ether 0.3%,
Polyethylene Glycol 0.45%,
Glycerin 0.5%,
Tween 80 0.3%,
Mentholum 0.3%,
Borneolum Syntheticum 0.35%,
Medical alcohol 18%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.2%, two decyl alkyl dimethyl ammonium chlorides of 0.15%, 0.25% benzalkonium bromide, 0.5% glycerin and 0.3% Tween 80 add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.3%, 0.45% Polyethylene Glycol, 0.3% Mentholum, 0.35% Borneolum Syntheticum, 18% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 10
A kind of skin mucous membrane disinfectants, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.25%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.1%,
Benzalkonium bromide 0.25%,
Trichloro hydroxyl diphenyl ether 0.2%,
Polyethylene Glycol 0.35%,
Glycerin 0.6%,
Tween 80 0.4%,
Mentholum 0.35%,
Borneolum Syntheticum 0.25%,
Medical alcohol 20%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.25%, two decyl alkyl dimethyl ammonium chlorides of 0.1%, 0.25% benzalkonium bromide, 0.6% glycerin and 0.4% Tween 80 add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.2%, 0.35% Polyethylene Glycol, 0.35% Mentholum, 0.25% Borneolum Syntheticum, 20% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 11
A kind of skin mucous membrane disinfectants, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.15%,
Benzalkonium bromide 0.35%,
Trichloro hydroxyl diphenyl ether 0.25%,
Polyethylene Glycol 0.35%,
Glycerin 0.65%,
Tween 80 0.45%,
Mentholum 0.35%,
Borneolum Syntheticum 0.35%,
Medical alcohol 25%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.5%, two decyl alkyl dimethyl ammonium chlorides of 0.15%, 0.35% benzalkonium bromide, 0.65% glycerin and 0.45% Tween 80 add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.25%, 0.35% Polyethylene Glycol, 0.35% Mentholum, 0.35% Borneolum Syntheticum, 25% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 12
A kind of skin mucous membrane disinfectants, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.3%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.2%,
Benzalkonium bromide 0.4%,
Trichloro hydroxyl diphenyl ether 0.4%,
Polyethylene Glycol 0.2%,
Glycerin 0.8%,
Tween 80 0.25%,
Mentholum 0.3%,
Borneolum Syntheticum 0.25%,
Medical alcohol 15%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.3%, two decyl alkyl dimethyl ammonium chlorides of 0.2%, 0.4% benzalkonium bromide, 0.8% glycerin and 0.25% Tween 80 add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.4%, 0.2% Polyethylene Glycol, 0.3% Mentholum, 0.25% Borneolum Syntheticum, 15% medical alcohol mixing stirring and dissolving become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Embodiment 13
A kind of skin mucous membrane disinfectants, can also compare according to following percentage by weight set of dispense:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.35%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chlorides 0.25%,
Benzalkonium bromide 0.15%,
Trichloro hydroxyl diphenyl ether 0.15%,
Polyethylene Glycol 0.2%,
Glycerin 0.45%,
Tween 80 0.2%,
Mentholum 0.25%,
Borneolum Syntheticum 0.3%,
Medical alcohol 30%,
All the other are ionized water.
The method for preparing of above-mentioned disinfectant solution is:
A, the two decyl dimethyl ammonium bromide with 0.35%, two decyl alkyl dimethyl ammonium chlorides of 0.25%, 0.15% benzalkonium bromide, 0.45% glycerin and 0.2% Tween 80 add ionized water and are dissolved in the agitated reactor, are stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15%, 0.2% Polyethylene Glycol, 0.25% Mentholum, 0.3% Borneolum Syntheticum, the medical alcohol mixing stirring and dissolving of 10-30% become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
Claims (4)
1. skin mucous membrane disinfectants is characterized in that comprising that the component of proportioning is as following weight percent:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2-0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chloride 0.1-0.3%,
Benzalkonium bromide 0.15-0.4%,
Trichloro hydroxyl diphenyl ether 0.15-0.4%,
Mentholum 0.2-0.4%,
Borneolum Syntheticum 0.2-0.4%,
Medical alcohol 10-30%,
All the other are ionized water.
2. according to the method for preparing of the said a kind of skin mucous membrane disinfectants of claim 1, it is characterized in that step is following:
A, the benzalkonium bromide of the two decyl alkyl dimethyl ammonium chlorides of two decyl dimethyl ammonium bromide of 0.2-0.5%, 0.1-0.3% and 0.15-0.4% is added ionized water be dissolved in the agitated reactor, be stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15-0.4%, the Mentholum of 0.2-0.4%, the Borneolum Syntheticum of 0.2-0.4%, the medical alcohol mixing stirring and dissolving of 10-30% become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product.
3. skin mucous membrane disinfectants comprises according to the component of following percentage by weight proportioning:
Double-chain quaternary ammonium salt---two decyl dimethyl ammonium bromide 0.2-0.5%,
Double-chain quaternary ammonium salt---two decyl alkyl dimethyl ammonium chloride 0.1-0.3%,
Benzalkonium bromide 0.15-0.4%,
Trichloro hydroxyl diphenyl ether 0.15-0.4%,
Polyethylene Glycol 0.2-0.6%,
Glycerin 0.4-0.8%,
Tween 80 0.2-0.6%,
Mentholum 0.2-0.4%,
Borneolum Syntheticum 0.2-0.4%,
Medical alcohol 10-30%,
All the other are ionized water.
4. according to the method for preparing of the said a kind of skin mucous membrane disinfectants of claim 3, it is characterized in that step is following:
A, the Tween 80 of the glycerin of the benzalkonium bromide of two decyl alkyl dimethyl ammonium chlorides of two decyl dimethyl ammonium bromide of 0.2-0.5%, 0.1-0.3%, 0.15-0.4%, 0.4-0.8% and 0.2-0.6% is added ionized water be dissolved in the agitated reactor, be stirred to solution;
B, the trichloro hydroxyl diphenyl ether with 0.15-0.4%, the Polyethylene Glycol of 0.2-0.6%, the Mentholum of 0.2-0.4%, the Borneolum Syntheticum of 0.2-0.4%, the medical alcohol mixing stirring and dissolving of 10-30% become solution;
C, the solution that steps A and step B are obtained all join in the agitated reactor, add ionized water, are heated to 20-50 ℃ and stir 2-4 hour, leave standstill then 24-28 hour, filter fill, make finished product;
Through adopting double-chain quaternary ammonium salt and benzalkonium bromide (C
20H
40BrN) be main sterilization component all, be aided with trichloro hydroxyl diphenyl ether (C
12H
7Cl
3O
2), Polyethylene Glycol (HOCH
2(CH
2OCH
2) nCH
2OH), glycerin (C
3H
8O
3), the various skin mucous membrane disinfectants processed of Tween 80, Mentholum, Borneolum Syntheticum, medical alcohol, all have the disinfectant effect.
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| CN102119840A (en) * | 2011-03-10 | 2011-07-13 | 胡万宁 | Hospital infection preventing disposable hand cleaning disinfecting towel for medical personnel and use thereof |
| CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
| CN104757019A (en) * | 2015-03-23 | 2015-07-08 | 苏州谷力生物科技有限公司 | Composite sanitizer and preparation method thereof |
| CN105125536B (en) * | 2015-07-29 | 2018-05-04 | 无锡宏瑞生物医药科技有限公司 | Treat bacterium, fungi, virus or dermopathic composition caused by parasite |
| CN106420683A (en) * | 2016-08-30 | 2017-02-22 | 郑州嘉泰生物科技有限公司 | Highly-efficient antibacterial liquid used for skin mucous membrane |
| CN106511427A (en) * | 2016-12-27 | 2017-03-22 | 四川默森药业有限公司 | Composition for skin mucous membrane disinfection and preparation method of composition |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
| CN113631155A (en) * | 2020-04-27 | 2021-11-09 | 陕西高源体外诊断试剂有限公司 | Disinfectant composition, preparation method and application thereof |
| CN111811075A (en) * | 2020-07-17 | 2020-10-23 | 姹ゅ嘲 | Application of skin mucosa disinfectant with virus inactivation effect in air purification |
| CN111637566A (en) * | 2020-07-17 | 2020-09-08 | 汤峰 | Medical grade air purification device |
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