CN106420683A - Highly-efficient antibacterial liquid used for skin mucous membrane - Google Patents
Highly-efficient antibacterial liquid used for skin mucous membrane Download PDFInfo
- Publication number
- CN106420683A CN106420683A CN201610815976.3A CN201610815976A CN106420683A CN 106420683 A CN106420683 A CN 106420683A CN 201610815976 A CN201610815976 A CN 201610815976A CN 106420683 A CN106420683 A CN 106420683A
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- China
- Prior art keywords
- antimicrobial fluid
- quaternary ammonium
- ammonium salt
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- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to highly-efficient antibacterial liquid used for skin mucous membrane. The antibacterial liquid is characterized by comprising, by weight, 1-3 parts of compound quaternary ammonium salt, 1-2 parts of surface active agent, 1-2 parts of glycerinum, 1-2 parts of borneol, and proper amount of pH value modifier. Purified water is added to 100 parts to adjust pH to be 5-6. The highly-efficient antibacterial liquid used for the skin mucous membrane can efficiently kill all the invasive organisms such as gram-positive bacterium, gram-negative bacterium and fungus, and generate no skin irritation, irritability and cytotoxicity.
Description
Technical field
The present invention relates to daily use chemicals, medical apparatus and instruments and disinfectant field, more specifically for, the present invention relates to a kind of efficient
Mucocutaneous use antimicrobial fluid.
Background technology
According to Development history, quaternary ammonium salt can be divided at least 7 generation products：1st generation product is conventional specific alkyl
Alkyl dimethyl benzyl ammonium chloride (benzalkonium chloride) of distribution ratio；2nd generation product is that fragrant ring hydrogen is substituted by chlorine, first
Base or ethyl and the replacement zephiran that formed, such as alkyl dimethyl benzyl ammonium chlorination；3rd generation product is 1st generation and 2nd generation season
The mixture of ammonium salt, with milestone significance.4th generation product is double long chain quaternaries, product type have double octyl groups, double decyls,
The multiple combination form such as double dodecyls, octyl-decyl, its bactericidal effect is remarkably reinforced.Such as：Double certain herbaceous plants with big flowers base ditallowdimethyl ammonium bromide, double
Certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, dimethyl benzyl ammonium chloride, bromination double (dodecyl dimethyl) ethylene diammonium, 2 one (2 one benzene oxygen
Base oxethyl) ethyl-trimethyl salmiac, and zephiran mixed with octyl group certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride
Thing, i.e. Sha Biling etc..5th generation product mixes quaternary ammonium salt for the 4th generation with 1st generation.The 3rd generation quaternary ammonium salt formula has been drawn in this combination
Synergetical principle make, its bactericidal effect is superior to single component, and anti-interference strong, small toxicity, and price is relatively low.7th
It is polymeric quaternary ammonium salts for product.Which is mainly characterized in that toxicity is less, and bactericidal action is more gentle, weaker than previous generations product.
Traditional single long-chain and double long chain quaternaries need to compound ethanol, glutaraldehyde, o-phthalaldehyde(OPA), Wu Luo in low concentration
Tropine, chlorhexidine acetate etc. can be only achieved the requirement of quick sterilization, and there is inflammability, effumability, zest, sensitization
Etc. defect, therefore we need to develop new quaternary ammonium salt antimicrobial fluid to meet the market demand.
Content of the invention
In order to overcome the existing shortcoming of conventional quaternary ammonium salts class antimicrobial fluid, the present invention utilizes the quaternary ammonium salt product development of the 5th generation
A kind of efficient skin mucosa antimicrobial fluid.The skin mucosa antimicrobial fluid has that quick sterilization, skin irritation be little, after use
The advantages of skin is moist, is therefore applied to the disinfection of skin mucosa.
The present invention is achieved through the following technical solutions：
A kind of efficiently mucocutaneous use antimicrobial fluid, it is characterised in that：Following compositions including following weight parts：Compound season
Ammonium salt 1-3 part, surfactant 1-2 part, glycerol 1-2 part, Borneolum Syntheticum 1-2 part, appropriate pH value regulator, purified water adds to 100 parts,
The highly effective skin mucous membrane disinfectants pH is 5-6.
The compound quaternary ammonium salt be bardac 205M quaternary ammonium salt, bardac 208M quaternary ammonium salt or its combination；Concentration is
1.0%-3.0%.
The surfactant is TWEEN Series (20,40,60,80,85) and span (Span) series.
The efficient skin mucosa antimicrobial fluid does not produce skin irritation, anaphylaxis and cytotoxicity.
The efficient skin mucosa antimicrobial fluid is pathogenic to gram positive bacteria, gram negative bacteria, funguses etc. micro-
Biology all effectively can be killed.
Specific embodiment
Specific embodiment one：
A kind of highly effective skin mucosa antimicrobial fluid, including the following compositions of following weight parts：Bardac 208M quaternary ammonium salt 2
Part, 1 part of Tween 80,1 part of glycerol, 1 part of Borneolum Syntheticum, purified water adds to 100 parts, and it is 5-6 that lactic acid adjusts pH.
Specific embodiment two：
A kind of highly effective skin mucosa antimicrobial fluid, including the following compositions of following weight parts：Bardac 205M quaternary ammonium salt 2
Part, 2 parts of Tween 80,1 part of glycerol, 1 part of Borneolum Syntheticum, purified water adds to 100 parts, and it is 5-6 that lactic acid adjusts pH.
These are only that the present invention's is embodied as a case part, all changes that is made according to claims of the present invention, institute
When the function of generation is without departing from the scope that claims of the present invention is required, protection scope of the present invention is belonged to.
Claims (5)
1. a kind of efficient skin mucosa antimicrobial fluid, it is characterised in that：Following compositions including following weight parts：Compound quaternary ammonium
Salt 1-3 part, surfactant 1-2 part, glycerol 1-2 part, Borneolum Syntheticum 1-2 part, appropriate pH value regulator, purified water adds to 100 parts, institute
Highly effective skin mucous membrane disinfectants pH is stated for 5-6.
2. a kind of efficiently mucocutaneous use antimicrobial fluid according to claim 1, it is characterised in that：The compound quaternary ammonium salt
For bardac 205M quaternary ammonium salt, bardac 208M quaternary ammonium salt or its combination；Concentration is 1%-3%.
3. a kind of efficiently mucocutaneous according to claim 1 uses antimicrobial fluid：It is characterized in that：The surface activity
Agent is TWEEN Series (20,40,60,80,85) and span (Span) series.
4. a kind of efficiently mucocutaneous according to claim 1 uses antimicrobial fluid：It is characterized in that：Described one kind is high
The skin mucosa antimicrobial fluid of effect does not produce skin irritation, anaphylaxis and cytotoxicity.
5. according to right 1 require described in a kind of efficiently mucocutaneous use antimicrobial fluid, it is characterised in that：Described one kind is high
The skin mucosa antimicrobial fluid of effect all effectively can be killed to invasive organisms such as gram positive bacteria, gram negative bacteria, funguses
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610815976.3A CN106420683A (en) | 2016-08-30 | 2016-08-30 | Highly-efficient antibacterial liquid used for skin mucous membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610815976.3A CN106420683A (en) | 2016-08-30 | 2016-08-30 | Highly-efficient antibacterial liquid used for skin mucous membrane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106420683A true CN106420683A (en) | 2017-02-22 |
Family
ID=58169335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610815976.3A Pending CN106420683A (en) | 2016-08-30 | 2016-08-30 | Highly-efficient antibacterial liquid used for skin mucous membrane |
Country Status (1)
| Country | Link |
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| CN (1) | CN106420683A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248199A (en) * | 2018-10-22 | 2019-01-22 | 安徽亿人安股份有限公司 | A kind of antibiotic preparation and its application |
| CN111166841A (en) * | 2020-01-06 | 2020-05-19 | 成都润兴消毒药业有限公司 | Skin disinfection combined medicament and preparation method and use method thereof |
| CN113825399A (en) * | 2017-06-15 | 2021-12-21 | 涤康7号系统股份公司 | Chemical and biological decontamination formulation with enhanced kill effect |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006027551A2 (en) * | 2004-09-11 | 2006-03-16 | Reckitt Benckiser Inc | Improvements in or relating to organic compositions |
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
| CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN105746562A (en) * | 2016-03-31 | 2016-07-13 | 山东威高药业股份有限公司 | Liquid disinfectant |
-
2016
- 2016-08-30 CN CN201610815976.3A patent/CN106420683A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006027551A2 (en) * | 2004-09-11 | 2006-03-16 | Reckitt Benckiser Inc | Improvements in or relating to organic compositions |
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
| CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN105746562A (en) * | 2016-03-31 | 2016-07-13 | 山东威高药业股份有限公司 | Liquid disinfectant |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113825399A (en) * | 2017-06-15 | 2021-12-21 | 涤康7号系统股份公司 | Chemical and biological decontamination formulation with enhanced kill effect |
| CN109248199A (en) * | 2018-10-22 | 2019-01-22 | 安徽亿人安股份有限公司 | A kind of antibiotic preparation and its application |
| CN111166841A (en) * | 2020-01-06 | 2020-05-19 | 成都润兴消毒药业有限公司 | Skin disinfection combined medicament and preparation method and use method thereof |
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Application publication date: 20170222 |
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