CN101933521B - Preparation and application thereof of sterilization composition - Google Patents
Preparation and application thereof of sterilization composition Download PDFInfo
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- CN101933521B CN101933521B CN 200910087613 CN200910087613A CN101933521B CN 101933521 B CN101933521 B CN 101933521B CN 200910087613 CN200910087613 CN 200910087613 CN 200910087613 A CN200910087613 A CN 200910087613A CN 101933521 B CN101933521 B CN 101933521B
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Abstract
The invention relates to preparation and application of a sterilization composition containing various effective sterilization components. The sterilization composition contains a guanidine compound, a quarternary ammonium compound, 2-bromine-2-nitro-1,3-propanediol and ethanol, is diluted within a range of 50-1000 times, has the average killing rate of 99.99-99.9999 percent to gonites, bacterialspores, mycobacteria, viruses, fungi and spores thereof, can be used for the public health field, the food processing industry, the medical and health field, the livestock and poultry industry, the aquaculture industry and sterilization treatment on indoor air and in-vehicle air and can also be used for the port field, in particular to ship ballast water treatment, container treatment, industrialcirculating water treatment, swimming pool water treatment, hand and skin mucosa treatment, industrial wastewater treatment, hospital wastewater treatment and antiseptic treatment of a building material.
Description
Technical field
The invention belongs to the disinfection product scope, relate to a kind of preparation and application of sanitizing composition, especially a kind of composition with multiple effective sterilization component is as preparation and the application of thimerosal, wherein contain guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, the composition of ammediol, ethanol is as preparation and the application of thimerosal.
Background technology
For a long time, extensively adopt chlorine-containing disinfectant, brominated disinfectant, guanidine class disinfectant and quaternary ammonium disinfectant in the sterile products field always.
The disinfection principle of chlorine-containing disinfectant is based on chlorine-containing disinfectant hypochlorous bactericidal action by generating behind the hydrolysis in water.But chlorine-containing disinfectant is found following shortcoming in long-term use:
1, the pH value narrow range of effective killing microorganisms of chlorine-containing disinfectant, its minimum dissociation reaction occurs in the pH7.0 place, and when the pH value continued to raise, hypochlorous acid was dissociated into the hypochlorite ion of the power extreme difference of killing livestock easily in a large number.Because hypochlorite ion has negative electrical charge, when its when the microorganism, be subjected to the anion exclusion of load on the microorganism wall, be difficult to permeate through cell membranes, therefore just lost the vigor of killing microorganisms.
2, chlorine-containing disinfectant can also with water in organic matter generate the carcinogenic substance chloroform.
3, the smelly pungent taste of unpleasant chlorine is arranged, skin is had excitant.
4, the solvability in water is little, and dissolution velocity is slow, has influenced it greatly as the application of disinfectant in the sterilization field.
5, guanidine class disinfectant and quaternary ammonium disinfectant all belong to low effect disinfectants, but only kill vegetative forms of bacteria and lipophilic virus, but can not kill mycobacterium, virus (except lipophilic virus), fungi and spore thereof etc., can not kill bacteria gemma (pathogenic gemma bacterium), influenced it so greatly as the extensive use of disinfectant in the sterilization field.
Summary of the invention
The objective of the invention is to provides a kind of preparation and application thereof of sanitizing composition at the various drawbacks of existing disinfectant with for solving the technical problem that exists in the known technology, especially with preparation and the application as thimerosal of the composition of multiple effective sterilization component, it has characteristics such as safety, efficient, wide spectrum, low toxicity, environmental protection.
In order to satisfy in the actual production demand of preventing and treating to disease, people also can select various disinfectant disinfections usually for use, yet the kind of chemosterilant is a lot, its mechanism of action also has nothing in common with each other, killing action for various pathogenic microorganismss is also different, obtain significant curative effect and just must select correct medicament kind, simultaneously, also must select proper drug concentration for use.
One of purpose of the present invention provides a kind of sanitizing composition, especially a kind of thimerosal with multiple effective sterilization combination of components: sanitizing composition of the present invention contains component down:
The component of said composition can comprise the component of following weight portion:
In addition, can also on the basis of above-mentioned parts by weight of component, comprise the ethylenediamine tetra-acetic acid of 0.01-1 weight portion, the non-ionic surface active agent of 0-2 weight portion.Non-ionic surface active agent is selected from: the mixture of one or more among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong.
Particularly, can comprise following components in weight percentage:
In addition, can also on the basis of above-mentioned percentage by weight component, comprise the ethylenediamine tetra-acetic acid of 0.01-1 weight %, the non-ionic surface active agent of 0-2 weight %.The agent of drawing together property of non-ionic surface is selected from: the mixture of one or more among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong.
Wherein said guanidine compound is selected from: the mixture of one or more in polyhexamethylene guanide, poly hexamethylene biguanide, poly-hexamethylene guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine, or one or more mixture of above-mentioned each guanidine compound pharmaceutically acceptable salt;
Hydrochloride in the polyhexamethylene guanide is a kind of white amorphous powder, and no special odor is soluble in water, and the aqueous solution is colourless to faint yellow, tasteless, does not fire not quick-friedly, and metal material is not had corrosion substantially, and decomposition temperature is greater than 400 ℃, and molecular formula is (C
7H
16N
3Cl)
n, to the handle no discoloration in surface, undergoing no deterioration in 2 years, the aqueous solution of 0.1% concentration has the taste of little hardship.Very extensive in the every field application, can be used as the candida albicans disinfectant of various body surfaces, and can make daily mould inhibitor; Can be widely used in beverage and food-processing industry, drinking water and swimming pool, lake water, pool, cooling tower, fountain, except algae, oil exploitation, construction material mildewproof additive, plant's sterilization, and be used for textile industry, paper-making industry, wood-processing industry, rubber industry, agricultural etc., also can be used as the flocculant of waste water treatment.
Poly hexamethylene biguanide, its colorless and odorless, water-soluble fully, stable in properties, its bactericidal mechanism is different with chlorine-containing disinfectant, strong oxidation reaction does not take place in the sterilization process, produce precipitation in the cell, the quantity of endocellular phosphorus rises simultaneously, thereby block cell wall and nucleic acid is synthetic; Reduce the cell permeability of the membrane, stop phosphorus to cell exocrine, and the energy bind protein, this disinfectant is widely used in pharmaceuticals industry, has when reporting it as mouthwash, and is very strong to the Gram-negative bacteria property killed.
Described quaternary ammonium compound is selected from: the mixture of one or more of benzalkonium bromide, benzalkonium chloride, n-zephiran and two n-alkyl-dimethyl ammonium chlorides;
Wherein the n in the n-zephiran is 8-16, as hexadecyldimethyl benzyl ammonium benzyl oronain,
Molecular formula: C
25H
46NCl is white or light yellow solid.Soluble in water, ethanol is insoluble to benzene, ether.The fusing point of pure product is 68 ℃, has cleaning, bactericidal action.Character with typical cationic surfactants can produce a large amount of foams during its aqueous solution brute force vibration.Good dispersion is arranged, peel off the foundry loam effect.Stable in properties, fast light, heat-resisting, non-volatility, but long term storage.
N in two n-alkyl-dimethyl ammonium chlorides is 8-14.Two n-alkyl-dimethyl ammonium chlorides are two long chain quaternaries.Product type has multiple combining forms such as two octyl groups, two decyl, two dodecyl, octyl-decyl, and its bactericidal effect obviously strengthens.As: two certain herbaceous plants with big flowers base dimethyl ammonium bromides, two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, 2-(2-phenoxy group ethyoxyl) ethyl-trimethyl salmiac etc.
2-bromo-2-nitro-1, ammediol, it is white or canescence crystalline powder, fusing point is greater than 120 ℃, and is soluble in water.Have the high-efficiency broad spectrum antibacterial activity, be widely used as cosmetics preservative, also as agriculture chemicals fungicide, medical disinfectant, with the composite industrial water conditioning agent etc. that also can be used as of other preservatives.
Each component is role in the present invention:
Guanidine compound belongs to cationic surfactant described in the component, is low effect disinfectants, has quick-acting bactericidal actions, to mucocutaneous nonirritant, to metal and fabric non-corrosiveness, is subjected to organic substance influence slight, good stability.
Quaternary ammonium compound belongs to cationic surfactant described in the component, is low effect disinfectants, and to mucocutaneous non-stimulated, toxicity is little, and good stability is harmless to article.
The bromo-of 2-described in component 2-nitro-1, the ammediol material is white or off-white color crystal type powder, and is tasteless, soluble in water, broad spectrum antibiotic activity can effectively suppress Gram-negative bacteria, positive bacteria, saccharomycete and mould.
Ethanol described in the component all has synergistic effect, makes the composite high effect disinfectants that becomes of above-mentioned substance, has hydrotropy and antifreeze effect simultaneously.
The optimum ratio of sanitizing composition of the present invention is as follows:
Perhaps, can also in the sanitizing composition of above-mentioned preferred weight part proportioning, add the water of an amount of weight portion.
Sanitizing composition of the present invention is the proportioning of following percentage by weight most preferably:
Guanidine compound described in the component comprises one or more the mixture in poly (hexamethylene) hydrochloride, hexamethylene, poly-hexamethylene guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine etc.;
Quaternary ammonium compound described in the component comprises one or more the mixture in benzalkonium bromide, benzalkonium chloride, n-zephiran and the two n-alkyl-dimethyl ammonium chloride; Wherein the n in the n-zephiran is 8-16, and the n in two n-alkyl-dimethyl ammonium chlorides is 8-14.
Ionic surfactant pack described in the component is drawn together one or more the mixture among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong etc.; Non-ionic surface active agent is the de-sludging cleaning agent, uses bactericidal action very weak separately.
The material of ethylenediamine tetra-acetic acid described in the component has chelating and complexing, can remove the Ca that exists in the water
2+, Mg
2+, Fe
2+, Mn
2+Deng metal ion, reach purification.
Water in the component can be selected deionized water.
Another object of the present invention is, a kind of compound method of thimerosal is provided, especially contain guanidine compound, quaternary ammonium compound, 2-bromo-2-nitro-1, the composition of ammediol is as the preparation of thimerosal, and it mainly is to adopt guanidine compound and quaternary ammonium compound, adequate amount of ethanol, ethylenediamine tetra-acetic acid, non-ionic surface active agent, 2-bromo-2-nitro-1.3-propane diols and deionized water to be prepared from through mixing, react, stir, leaving standstill:
The compound method of the above-mentioned sanitizing composition that contains the percentage by weight component is as follows:
1), with guanidine compound and quaternary ammonium compound, ethanol, ethylenediamine tetra-acetic acid, non-ionic surface active agent, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight and stirred 3 hours;
2), with above-mentioned substance and deionized water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Purpose of the present invention also comprises provides the sterilization of above-mentioned sanitizing composition purposes:
Above-mentioned sanitizing composition can be applicable to the sterilization in following field:
1, public health field, food-processing industry, medicine and hygiene fields, especially prevention and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc. and prevention and kill bacteria gemma (pathogenic gemma bacterium);
2, livestock and poultry cultivation industry, aquaculture industry, especially prevention and kill vegetative forms of bacteria, mycobacterium, virus, fungi and spore thereof etc. and prevention and kill bacteria gemma (pathogenic gemma bacterium);
3, air sterillization in disinfection of indoor air, the car, especially prevention and kill bacteria are tightly grown body, mycobacterium and virus;
4, especially ship ballast water processing and container processing, particularly prevention and kill vegetative forms of bacteria, mycobacterium, virus, fungi and bacterial spore (pathogenic gemma bacterium) of field, port;
5, industrial cycle water treatment and swimming-pool water are handled, especially prevention and kill vegetative forms of bacteria;
6, hand and skin and mucosa are handled, especially prevention and kill vegetative forms of bacteria, fungi;
7, industrial sewage is handled and Hospital Sewage Treatment, especially prevention and kill vegetative forms of bacteria, fungi, mycobacterium, virus, fungi and bacterial spore (pathogenic gemma bacterium);
8, the mildew-resistant of construction material is handled, especially as mildewproof additive.
Combination matching between each component of sanitizing composition of the present invention has the effect of Synergistic, has following advantage and good effect:
1, harmless to people, animal, can not produce harmful substance;
2, non-stimulated to skin and mucosa;
3, article and fabric there is not corrosivity;
4, have no irritating odor, colourless;
5, sterilization wide spectrum, valid density is low, and speed of action is fast, and stable performance is soluble in water, is not subjected to the influence of environment, organic matter, acid, alkali and other physics, chemical factor.
The experimental study that sanitizing composition product of the present invention is carried out:
The sterilization experiment contrast (cooperative synergism effect experiment) of experimental example 1 described thimerosal and one-component thimerosal:
1, the prescription of one-component thimerosal and compound disinfectant is formed:
2, experimental result
Investigate by above-mentioned experimental technique, when guanidine compound that will be wherein is selected from: the mixture of one or more in polyhexamethylene guanide, poly-hexamethylene guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine, or be selected from the mixture of above-mentioned guanidine compound and poly hexamethylene biguanide; Quaternary ammonium compound is selected from the quaternary ammonium compound except dodecyl benzyl dimethyl ammonium chloride: during the mixture of one or more in benzalkonium bromide, benzalkonium chloride, n-zephiran and the two n-alkyl-dimethyl ammonium chloride (wherein the n in the n-zephiran is 8-16, and the n in two n-alkyl-dimethyl ammonium chlorides is 8-14); Also obtained the effect as the same Synergistic of experimental example 1 (cooperative synergism effect experiment), namely ideal with the bactericidal effect of A+B+C+D, simultaneously, the combining form of the A+B+C+D of described product is being investigated bacterial propagule, bacterial spore, mycobacterium, virus, killing in the process of fungi and spore etc. thereof, the Disinfection Effect that has equally also shown the good Synergistic of A+B+C+D combination, be that special feature of the present invention is, guanidine compound, quarternary ammonium salt compound and ethanol, the 2-bromo-2-nitro-1 of minute quantity, after the ammediol combination, it has outstanding antimicrobial activity, this activity is to be predicted out by the bactericidal action of known single component, the present invention has been found that guanidine compound by experiment, quaternary ammonium compounds, ethanol, 2-bromo-2-nitro-1, these several components of ammediol, under following percentage by weight, have above-mentioned good Synergistic antimicrobial activity, in general, the guanidine compound percentage by weight is from 1%-5%; The quaternary ammonium compound percentage by weight is from 1%-10%; The ethanol percentage by weight is from 1%-70%; 2-bromo-2-nitro-1, the ammediol percentage by weight is from 0.1%-2%.
In addition, in order to reach the purpose of purification, can also add the ethylenediamine tetra-acetic acid with chelating and complexing in the sanitizing composition of above-mentioned any combining form, its percentage by weight is from 0.01%-1%; Simultaneously also can add the non-ionic surface active agent with de-sludging cleaning function, as one or more the mixture among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong, its percentage by weight is from 0%-2%.
The effect experiment of experimental example 2 sanitizing compositions of the present invention
Be example with the following example 1 described sterilization combination product, carry out the killing effect experiment:
1, with test bacteria concentration 10
6/ ml bacterium is counted meter, 50 times of sanitizing composition of the present invention dilutions or when diluting 100 times, can reach more than 99.999% to Escherichia coli and 5 minutes sterilizing rates of staphylococcus aureus effect, white is read 5 minutes sterilizing rates of coccus effect can reach more than 99.99%, can reach more than 99% to public environment and 10 minutes sterilizing rates of body surface natural bacteria effect; When diluting 1000 times, can reach more than 99.99% to Escherichia coli and 5 minutes sterilizing rates of staphylococcus aureus effect, white is read 5 minutes sterilizing rates of coccus effect can reach more than 99.99%, can reach more than 99% public environment and 10 minutes sterilizing rates of body surface natural bacteria effect.
2, to virus, be that representative was diluted 100 times of effects in the time of 5 minutes with influenza A virus, AIDS virus, the inactivation of virus rate can reach more than 99.99%, and in the time of 5 minutes, the inactivation of virus rate can reach more than 99.99% at 500 times of diluting effects.
Embodiment
Embodiment 1
1), with poly hexamethylene biguanide and benzalkonium bromide, 95% ethanol, ethylenediamine tetra-acetic acid, polyoxyethylene nonylphenol ether, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned weight and stirred 3 hours;
2), with said components and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 2
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Polyhexamethylene guanide | 10 | 1.0％ |
| Cetalkonium chloride | 20 | 2.0％ |
| 95% ethanol | 10 | 1.0％ |
| Ethylenediamine tetra-acetic acid | 1 | 0.1％ |
| Polyalcohol ether | 10 | 1.0％ |
| 2-bromo-2-nitro-1, ammediol | 5 | 0.5％ |
| Water | Surplus | 94.4％ |
| Amount to | 1000 | 100％ |
1), with polyhexamethylene guanide and cetalkonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, polyalcohol ether, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 3
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine | 20 | 2.0％ |
| Benzalkonium chloride | 50 | 5.0％ |
| 95% ethanol | 100 | 10.0％ |
| Ethylenediamine tetra-acetic acid | 1 | 0.1％ |
| Tween | 10 | 1.0％ |
| 2-bromo-2-nitro-1, ammediol | 2 | 0.2％ |
| Water | Surplus | 81.7％ |
| Amount to | 1000 | 100％ |
1), will gather [2-(2-ethyoxyl)-ethyoxyl second fat] guanidine and benzalkonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, tween, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 4
1), with polyhexamethylene guanide and didecyl Dimethy ammonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, Qu Latong, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 5
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Poly hexamethylene biguanide | 40 | 4.0％ |
| Ten alkyl-dimethyl ammonium chlorides | 80 | 8.0％ |
| 95% ethanol | 300 | 30.0％ |
| Ethylenediamine tetra-acetic acid | 1.5 | 0.15％ |
| Qu Latong | 5 | 0.5％ |
| 2-bromo-2-nitro-1, ammediol | 5 | 0.5％ |
| Water | Surplus | 56.85％ |
| Amount to | 1000 | 100％ |
1), with poly hexamethylene biguanide and ten alkyl-dimethyl ammonium chlorides, 95% ethanol, ethylenediamine tetra-acetic acid, Qu Latong, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 6
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Polyhexamethylene guanide | 30 | 3.0％ |
| Eight alkyl-dimethyl ammonium chlorides | 80 | 8.0％ |
| 95% ethanol | 30 | 3.0％ |
| Ethylenediamine tetra-acetic acid | 5 | 0.5％ |
| Polyoxyethylene nonylphenol ether | 5 | 0.5％ |
| 2-bromo-2-nitro-1, ammediol | 10 | 1.0％ |
| Water | Surplus | 84.0％ |
| Amount to | 1000 | 100％ |
1), with polyhexamethylene guanide and eight alkyl-dimethyl ammonium chlorides, 95% ethanol, ethylenediamine tetra-acetic acid, polyoxyethylene nonylphenol ether, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 7
1), with poly hexamethylene biguanide and two myristyl alkyl dimethyl ammonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, Qu Latong, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 8
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Polyhexamethylene guanide | 40 | 4.0％ |
| Dodecyl dimethyl ammonium chloride | 50 | 5.0％ |
| 95% ethanol | 50 | 5.0％ |
| Ethylenediamine tetra-acetic acid | 3 | 0.3％ |
| Tween | 1 | 0.1％ |
| 2-bromo-2-nitro-1, ammediol | 10 | 1.0％ |
| Water | Surplus | 84.6％ |
| Amount to | 1000 | 100％ |
1), with polyhexamethylene guanide and dodecyl dimethyl ammonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, tween, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 9
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Poly-hexamethylene guanidine | 30 | 3.0％ |
| Didecyl Dimethy ammonium chloride | 70 | 7.0％ |
| 95% ethanol | 20 | 2.0％ |
| Ethylenediamine tetra-acetic acid | 3 | 0.3％ |
| Polyalcohol ether | 1 | 0.1％ |
| 2-bromo-2-nitro-1, ammediol | 10 | 1.0％ |
| Water | Surplus | 86.6％ |
| Amount to | 1000 | 100％ |
1), will gather hexamethylene guanidine and didecyl Dimethy ammonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, polyalcohol ether, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Embodiment 10
| Form | Kilogram (Kg) | Percentage by weight (%) |
| Poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine | 20 | 2.0％ |
| Didecyl Dimethy ammonium chloride | 60 | 6.0％ |
| 95% ethanol | 20 | 2.0％ |
| Ethylenediamine tetra-acetic acid | 1 | 0.1％ |
| Qu Latong | 1 | 0.1％ |
| 2-bromo-2-nitro-1, ammediol | 10 | 1.0％ |
| Water | Surplus | 88.8％ |
| Amount to | 1000 | 100％ |
1), will gather [2-(2-ethyoxyl)-ethyoxyl second fat] guanidine and didecyl Dimethy ammonium chloride, 95% ethanol, ethylenediamine tetra-acetic acid, Qu Latong, 2-bromo-2-nitro-1, ammediol mixes by above-mentioned percentage by weight or weight and stirred 3 hours;
2), with above-mentioned substance and water mixing stirring reaction 2 hours, left standstill again 2 hours, mixed mixture is carried out assay, qualified mixture is packed, be qualified products.
Product with embodiment 1-10 gained, dilute with deionized water, dilution arbitrarily in 50-1000 scope doubly, bactericidal assay shows its effect 5min, all can reach more than 99.999% staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa average kill ratio, can reach more than 99.99% the Candida albicans average kill ratio.
The present invention is further elaborated by above embodiment, but does not limit the scope of the invention.
Claims (9)
1. sanitizing composition is characterized in that said composition comprises the component of following weight portion:
；
Wherein said guanidine compound is selected from: the mixture of one or more in polyhexamethylene guanide, poly hexamethylene biguanide, poly-hexamethylene guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine;
Described quaternary ammonium compound is selected from: the mixture of one or more in benzalkonium bromide, benzalkonium chloride, n-zephiran and the two n-alkyl-dimethyl ammonium chloride;
Wherein the n in the n-zephiran is 8-16, and the n in two n-alkyl-dimethyl ammonium chlorides is 8-14.
2. sanitizing composition as claimed in claim 1 is characterized in that said composition also comprises the component of following weight portion: ethylenediamine tetra-acetic acid 0.01-1, non-ionic surface active agent 0-2.
3. sanitizing composition as claimed in claim 2 is characterized in that described non-ionic surface active agent is selected from: the mixture of one or more among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong.
4. sanitizing composition as claimed in claim 1 is characterized in that said composition is to comprise following components in weight percentage:
；
Wherein said guanidine compound is selected from: the mixture of one or more in polyhexamethylene guanide, poly hexamethylene biguanide, poly-hexamethylene guanidine, poly-[2-(2-ethyoxyl)-ethyoxyl second fat] guanidine; Described quaternary ammonium compound is selected from: the mixture of one or more in benzalkonium bromide, benzalkonium chloride, n-zephiran and the two n-alkyl-dimethyl ammonium chloride; Wherein the n in the n-zephiran is 8-16, and the n in two n-alkyl-dimethyl ammonium chlorides is 8-14.
5. sanitizing composition as claimed in claim 4 is characterized in that said composition also comprises following components in weight percentage: ethylenediamine tetra-acetic acid 0.01%-1%, non-ionic surface active agent 0-2%.
6. sanitizing composition as claimed in claim 5 is characterized in that described non-ionic surface active agent is selected from: the mixture of one or more among polyoxyethylene nonylphenol ether, tween, polyalcohol ether, the Qu Latong.
7. sanitizing composition as claimed in claim 6 is characterized in that the percentage by weight of described component is:
。
8. as the described arbitrary sanitizing composition of claim 1-7, it is characterized in that: with described sanitizing composition dilution, dilution ratio is 50-1000 times.
9. application as the non-therapeutic purposes of the described arbitrary sanitizing composition of claim 1-8 is characterized in that being: the prevention and kill vegetative forms of bacteria, bacterial spore, mycobacterium, virus, fungi and the spore thereof that are used for health care, food processing field; The prevention and kill vegetative forms of bacteria, bacterial spore, mycobacterium, virus, fungi and the spore thereof that are used for livestock and poultry cultivation, aquaculture industry; Be used in the car, the sterilization of room air, prevention and kill vegetative forms of bacteria, bacterial spore, mycobacterium, virus, fungi and spore thereof; Prevention and kill vegetative forms of bacteria, bacterial spore, mycobacterium, virus, fungi and the spore thereof that ship ballast water is handled, container is handled that are used for the port; Be used for prevention and kill vegetative forms of bacteria that industrial circulating water and swimming-pool water are handled; Application for the preparation of the sanitizing composition of the prevention of hand, skin and mucosa and kill vegetative forms of bacteria, fungi; The prevention and kill vegetative forms of bacteria, bacterial spore, mycobacterium, virus, fungi and the spore thereof that are used for industry, medical sewage processing; The mildew-resistant that is used for the mildewproof additive of construction material is handled.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910087613 CN101933521B (en) | 2009-07-01 | 2009-07-01 | Preparation and application thereof of sterilization composition |
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|---|---|---|---|
| CN 200910087613 CN101933521B (en) | 2009-07-01 | 2009-07-01 | Preparation and application thereof of sterilization composition |
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| Publication Number | Publication Date |
|---|---|
| CN101933521A CN101933521A (en) | 2011-01-05 |
| CN101933521B true CN101933521B (en) | 2013-09-04 |
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| CN1476761A (en) * | 2003-07-02 | 2004-02-25 | 刘瑞源 | Liquid disinfectant |
| CN1647643A (en) * | 2004-12-29 | 2005-08-03 | 广州泰成消毒洗涤用品有限公司 | Disinfectant |
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