CN111202088A - Chlorhexidine acetate disinfectant and preparation method and application thereof - Google Patents
Chlorhexidine acetate disinfectant and preparation method and application thereof Download PDFInfo
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- CN111202088A CN111202088A CN202010151138.7A CN202010151138A CN111202088A CN 111202088 A CN111202088 A CN 111202088A CN 202010151138 A CN202010151138 A CN 202010151138A CN 111202088 A CN111202088 A CN 111202088A
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- disinfectant
- chlorhexidine acetate
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
Abstract
The invention belongs to the technical field of disinfection and sterilization medicines, and discloses a chlorhexidine acetate disinfectant and a preparation method and application thereof, wherein raw materials are prepared according to parts by weight, wherein the raw materials comprise 0.1% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 2% of chlorhexidine acetate with the purity of 99%, 2% of glycerol with the purity of 99%, 0.05% of essence with the purity of 99%, 60% of ethanol with the purity of 95%, and 35.85% of purified deionized water; dissolving fatty alcohol-polyoxyethylene ether, chlorhexidine acetate, glycerol and essence in an ethanol solution, and stirring to obtain a homogeneous solution; adding purified water to full volume, and performing constant volume and aging; inspecting the obtained intermediate product; if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product; and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse. The invention has the characteristics of disinfection, sterilization, skin protection, water retention, oil stain removal and fragrant smell, has stable chemical property, no corrosivity, no decoloring effect, broad-spectrum and high-efficiency sterilization.
Description
Technical Field
The invention belongs to the technical field of disinfection and sterilization medicines, and particularly relates to a chlorhexidine acetate disinfectant as well as a preparation method and application thereof.
Background
With the improvement of living standard of people, consumers have deeper understanding on clean and healthy life. Particularly, SARS, avian influenza and various infectious diseases are continuously generated, and people generally solve the problems by a disinfection method for prevention and control while having no effective method. Various disinfection and sterilization products are produced in the market, and the products are developed into a large category of daily chemicals.
Common disinfection liquid uses hypochlorite (such as calcium hypochlorite and sodium hypochlorite) as disinfection and sterilization component. Hypochlorite reacts with water to produce hypochlorous acid which is decomposed to release oxygen, thus achieving the aim of disinfection and sterilization. For example, the most commonly used 84 disinfectant contains water, but hypochlorous acid is unstable in chemical property and is easy to decompose at room temperature, especially under the illumination condition, so that the disinfection effect is reduced, therefore, the disinfectant is stored at the temperature of 25 ℃ in a dark place, and has corrosivity on metal and decoloration effect on colored fabrics such as cotton and hemp.
In summary, the problems of the prior art are as follows: the existing disinfectant contains water, but hypochlorous acid is unstable in chemical property and easy to decompose, so that the disinfection effect is reduced; it is corrosive to metal and has decolorizing effect on colored fabrics such as cotton and linen.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a chlorhexidine acetate disinfectant and a preparation method and application thereof.
The chlorhexidine acetate disinfectant is prepared from, by weight, 0.1% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 2% of chlorhexidine acetate with the purity of 99%, 2% of glycerol with the purity of 99%, 0.05% of essence, 60% of ethanol with the purity of 95%, and 35.85% of purified deionized water.
Furthermore, each 1000Kg of the chlorhexidine alcohol disinfectant consists of 1 Kg of fatty alcohol-polyoxyethylene ether, 20Kg of chlorhexidine acetate, 20Kg of glycerin, 0.5 Kg of essence, 600 Kg of ethanol and 358.5Kg of purified deionized water.
Another object of the present invention is to provide a method for preparing a chlorhexidine acetate disinfectant solution, which comprises the following steps:
preparing raw materials in parts by weight: 0.1 percent of fatty alcohol-polyoxyethylene ether with the purity of 99 percent, 2 percent of chlorhexidine acetate with the purity of 99 percent, 2 percent of glycerin with the purity of 99 percent, 0.05 percent of essence with the purity of 99 percent, 60 percent of ethanol with the purity of 95 percent and 35.85 percent of purified deionized water;
dissolving fatty alcohol-polyoxyethylene ether, chlorhexidine acetate, glycerol and essence in an ethanol solution, and stirring to obtain a homogeneous solution;
adding purified water to full volume, and performing constant volume and aging;
step four, inspecting the obtained intermediate product;
step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;
and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.
The chlorhexidine acetate disinfectant disclosed by the invention has the characteristics of disinfection and sterilization, skin protection and water retention, oil stain removal and fragrant smell, is stable in chemical property, non-corrosive to metal, free of decoloring effect, broad-spectrum and efficient in sterilization, free of stimulation to skin, and the optimal choice for disinfection products in daily life, and can enable users to feel more comfortable and safer. The invention aims to improve the stability and the disinfection effect of the existing disinfectant, and eliminate the corrosivity of the disinfectant on metal and the decoloring effect on colored fabrics such as cotton and linen.
The main components of the disinfectant comprise fatty alcohol-polyoxyethylene ether, chlorhexidine acetate, glycerol, essence and ethanol, and the disinfectant is characterized by containing the chlorhexidine acetate, has the main function of disinfection and sterilization, has the mechanism of destroying cell wall plasma membranes of pathogenic microorganisms and quickly killing gram-positive bacteria, gram-negative bacteria, bacterial spores, fungi, viruses and the like, and has the advantages of low toxicity, small toxic and side effects, no local stimulation, extremely rare allergic reaction and the like; the fatty alcohol-polyoxyethylene ether has the main functions of improving the affinity of oil stain and water and providing detergency, and has the characteristics of good detergency, insensitivity to hard water, small foam and the like as a nonionic surfactant; the glycerol has the main functions of moisturizing the skin and preventing the skin from being damaged by frequently using disinfectant; the function of the ethanol is to enhance the sterilization capability of the chlorhexidine acetate; water is used as a solvent; essence is an additive.
Chlorhexidine acetate has strong broad-spectrum antibacterial and bactericidal effects and low toxicity, and the mechanism of the chlorhexidine acetate is to destroy cell wall plasma membranes of pathogenic microorganisms and quickly kill gram-positive bacteria, gram-negative bacteria, bacterial spores, fungi, viruses and the like. According to the invention, the fatty alcohol-polyoxyethylene ether is added to enhance the decontamination capability of the disinfectant, the glycerin is added to enhance the skin-care and water-retention effects, the essence is added to make the odor fragrant, and the ethanol enhances the disinfection and sterilization effects. The disinfectant has the characteristics of disinfection, sterilization, skin protection, water retention, oil stain removal and fragrant smell, has stable chemical property, no corrosion to metal, no decoloring effect, broad-spectrum and high-efficiency sterilization, has no stimulation to skin, is the best choice for disinfection products in daily life, and can ensure that a user is more comfortable and safer.
Drawings
Fig. 1 is a flow chart of a method for preparing a chlorhexidine acetate disinfectant solution according to an embodiment of the present invention.
Fig. 2 is a flow chart of a production process of a chlorhexidine acetate disinfectant provided by an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The technical scheme of the invention is described in detail in the following with reference to the accompanying drawings.
The chlorhexidine acetate disinfectant provided by the embodiment of the invention consists of 0.1% of fatty alcohol polyoxyethylene ether with the purity of 99%, 2% of chlorhexidine acetate with the purity of 99%, 2% of glycerin with the purity of 99%, 0.05% of essence with the purity of 99%, 60% of ethanol with the purity of 95% and 35.85% of purified deionized water in parts by weight.
Every 1000Kg of chlorhexidine alcohol disinfectant provided by the embodiment of the invention consists of 1 Kg of fatty alcohol-polyoxyethylene ether, 20Kg of chlorhexidine acetate, 20Kg of glycerin, 0.5 Kg of essence, 600 Kg of ethanol and 358.5Kg of purified deionized water.
As shown in fig. 1, the preparation method of chlorhexidine acetate disinfectant provided by the embodiment of the present invention includes the following steps:
s101: preparing raw materials in parts by weight: 0.1 percent of fatty alcohol-polyoxyethylene ether with the purity of 99 percent, 2 percent of chlorhexidine acetate with the purity of 99 percent, 2 percent of glycerin with the purity of 99 percent, 0.05 percent of essence with the purity of 99 percent, 60 percent of ethanol with the purity of 95 percent and 35.85 percent of purified deionized water;
s102: dissolving fatty alcohol-polyoxyethylene ether, chlorhexidine acetate, glycerol and essence in an ethanol solution, and stirring to obtain a homogeneous solution;
s103: adding purified water to full volume, and performing constant volume and aging;
s104: inspecting the obtained intermediate product;
s105: if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;
s106: and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse.
The technical solution of the invention is further described below with reference to specific embodiments.
Example (b):
100kg of prescription composition:
| name of raw materials | CAS number | The addition amount Kg | Is calculated by the total amount |
| Fatty alcohol polyoxyethylene ether | 68213-23-0 | 1 | 0.1 |
| Chlorhexidine acetate | 18472-51-0 | 20 | 2 |
| Glycerol | 50-81-5 | 20 | 2 |
| Essence | —— | 0.5 | 0.05 |
| Ethanol | 64-17-5 | 600 | 60 |
| Water (W) | 7732-18-5 | 358.5 | 35.85 |
The common disinfectant such as 84 disinfectant is easy to decompose under illumination, is corrosive to metals, and has a decoloring effect on dyed fabrics such as cotton and linen. The disinfectant has no decontamination capability and pungent smell, and the skin is damaged after long-term frequent use.
The chlorhexidine acetate disinfectant disclosed by the invention has the characteristics of disinfection and sterilization, skin protection and water retention, oil stain removal and fragrance of smell, is stable in chemical property, free of corrosion to metal, free of decoloring effect, high in sterilization spectrum efficiency, free of stimulation to skin mucous membrane, and the optimal choice for disinfectant products in daily life, and can enable users to feel more comfortable and safer, besides the same disinfection and sterilization effect as that of products sold in the market is ensured.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (5)
1. The chlorhexidine acetate disinfectant is characterized by comprising, by weight, 0.1% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 2% of chlorhexidine acetate with the purity of 99%, 2% of glycerol with the purity of 99%, 0.05% of essence with the purity of 99%, 60% of ethanol with the purity of 95%, and 35.85% of purified deionized water.
2. The chlorhexidine acetate disinfectant of claim 1, wherein each 1000Kg of the chlorhexidine acetate disinfectant consists of 1 Kg of fatty alcohol-polyoxyethylene ether, 20Kg of chlorhexidine acetate, 20Kg of glycerin, 0.5 Kg of essence, 600 Kg of ethanol and 358.5Kg of purified deionized water.
3. The method for preparing a chlorhexidine acetate disinfectant solution according to claim 1, wherein the method for preparing the chlorhexidine alcohol disinfectant solution comprises the following steps:
preparing raw materials in parts by weight: 0.1 percent of fatty alcohol-polyoxyethylene ether with the purity of 99 percent, 2 percent of chlorhexidine acetate with the purity of 99 percent, 2 percent of glycerin with the purity of 99 percent, 0.05 percent of essence with the purity of 99 percent, 60 percent of ethanol with the purity of 95 percent and 35.85 percent of purified deionized water;
dissolving fatty alcohol-polyoxyethylene ether, chlorhexidine acetate, glycerol and essence in an ethanol solution, and stirring to obtain a homogeneous solution;
adding purified water to full volume, and performing constant volume and aging;
step four, inspecting the obtained intermediate product;
step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;
and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.
4. A disinfectant prepared from the chlorhexidine acetate disinfectant of any one of claims 1-2.
5. A bactericidal medicine prepared from the chlorhexidine acetate disinfectant as claimed in any one of claims 1-2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010151138.7A CN111202088A (en) | 2020-03-06 | 2020-03-06 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010151138.7A CN111202088A (en) | 2020-03-06 | 2020-03-06 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
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| CN111202088A true CN111202088A (en) | 2020-05-29 |
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| CN202010151138.7A Pending CN111202088A (en) | 2020-03-06 | 2020-03-06 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274561A (en) * | 2020-11-16 | 2021-01-29 | 四川宸煜林业开发有限责任公司 | Disinfectant containing camphor oil component and preparation method thereof |
Citations (9)
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| CN1041687A (en) * | 1988-10-11 | 1990-05-02 | 刘庆增 | Multifunctional disinfectant |
| JPH11209268A (en) * | 1998-01-12 | 1999-08-03 | Katsumi Kaneda | Canned spray of antiseptic solution (prepodyne or hibidale) |
| CN1488258A (en) * | 2002-10-08 | 2004-04-14 | 谢永军 | Air sterilizing disinfectant |
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| CN102085159A (en) * | 2011-01-24 | 2011-06-08 | 长沙优威生物科技有限公司 | Nursing type disinfecting liquid soap |
| CN102090993A (en) * | 2010-09-08 | 2011-06-15 | 成进学 | Anhydrous hand washing agent for sterilization and disinfection during paroxysmal calamities like earthquake and debris flow |
| CN105456548A (en) * | 2015-12-11 | 2016-04-06 | 郭健 | Foam disinfectant for medical use and preparation process of foam disinfectant |
| CN107753309A (en) * | 2016-08-15 | 2018-03-06 | 任汉学 | Disinfection hand cleanser and preparation method thereof |
| CN109125096A (en) * | 2018-08-14 | 2019-01-04 | 郑州吉尔康消毒制品有限公司 | Foam liquid soap and preparation method thereof |
-
2020
- 2020-03-06 CN CN202010151138.7A patent/CN111202088A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041687A (en) * | 1988-10-11 | 1990-05-02 | 刘庆增 | Multifunctional disinfectant |
| JPH11209268A (en) * | 1998-01-12 | 1999-08-03 | Katsumi Kaneda | Canned spray of antiseptic solution (prepodyne or hibidale) |
| CN1488258A (en) * | 2002-10-08 | 2004-04-14 | 谢永军 | Air sterilizing disinfectant |
| CN1565180A (en) * | 2003-06-16 | 2005-01-19 | 史英 | Antiseptic solution |
| CN102090993A (en) * | 2010-09-08 | 2011-06-15 | 成进学 | Anhydrous hand washing agent for sterilization and disinfection during paroxysmal calamities like earthquake and debris flow |
| CN102085159A (en) * | 2011-01-24 | 2011-06-08 | 长沙优威生物科技有限公司 | Nursing type disinfecting liquid soap |
| CN105456548A (en) * | 2015-12-11 | 2016-04-06 | 郭健 | Foam disinfectant for medical use and preparation process of foam disinfectant |
| CN107753309A (en) * | 2016-08-15 | 2018-03-06 | 任汉学 | Disinfection hand cleanser and preparation method thereof |
| CN109125096A (en) * | 2018-08-14 | 2019-01-04 | 郑州吉尔康消毒制品有限公司 | Foam liquid soap and preparation method thereof |
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| Title |
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| 朱兵等: "氯己定醇消毒液杀菌效果与毒性试验观察 ", 《中国消毒学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274561A (en) * | 2020-11-16 | 2021-01-29 | 四川宸煜林业开发有限责任公司 | Disinfectant containing camphor oil component and preparation method thereof |
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Application publication date: 20200529 |