CN111228304A - Virus-killing hand-washing-free disinfectant and preparation method thereof - Google Patents
Virus-killing hand-washing-free disinfectant and preparation method thereof Download PDFInfo
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 45
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 42
- 238000003756 stirring Methods 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 19
- -1 alkyl glycoside Chemical class 0.000 claims description 16
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 16
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 16
- 229930182470 glycoside Natural products 0.000 claims description 16
- 239000008213 purified water Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 2
- 229910001385 heavy metal Inorganic materials 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000001954 sterilising effect Effects 0.000 abstract description 4
- 241001478240 Coccus Species 0.000 abstract description 2
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000000968 intestinal effect Effects 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 2
- 241000235342 Saccharomycetes Species 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 8
- 239000006260 foam Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000005187 foaming Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical class N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
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- 230000008859 change Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
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- 230000000474 nursing effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
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- 239000013641 positive control Substances 0.000 description 1
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical class [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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Abstract
The invention discloses a virus-killing hand-washing-free disinfectant which is prepared from the following components in parts by weight: 1-2 parts of hydrogen peroxide, 900 parts of absolute ethyl alcohol 700-. The virus-killing hand-washing-free disinfectant prepared by the invention contains disinfection components, can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic saccharomycetes and common bacteria infected in hospitals, is prepared by compounding two or more main disinfection components, and is added with a proper stabilizing agent and a proper surfactant, so that the product has high stability, strong sterilization effect and good sterilization effect.
Description
Technical Field
The invention belongs to the technical field of disinfectant, and particularly relates to a virus-killing hand-washing-free disinfectant and a preparation method thereof.
Background
The hand is the most frequent part of the human body contacting the outside, various bacteria are easily polluted in daily work and life, and the attention on hand hygiene is crucial to prevention and health care. Especially in hospital environments, a large number of pathogenic microorganisms are present. Medical staff is inevitably polluted by pathogenic microorganisms in medical and nursing work, so the quantity and the sum of various bacteria on hands of the medical staff are more than those of other people, and the medical staff become one of the main factors causing nosocomial infection. Along with the improvement of the health consciousness of people, the hand hygiene cleaning product has wide market prospect.
The hand-washing-free disinfectant can play a hand-washing role without being washed by water, is not limited by a water source compared with the common hand sanitizer, is suitable for cleaning and disinfecting hands under the condition of water shortage, and is particularly suitable for hand washing and disinfecting of medical and health staff in certain occasions. Most of hand-washing-free disinfectant prepared in the prior art has the defects of strong pungent smell and great damage to hand skin.
Disclosure of Invention
In order to solve the problems, the invention provides the hand-washing-free disinfectant with remarkable sterilizing effect, small pungent smell and capability of removing superoxide anion free radicals in vitro and the preparation method thereof.
The invention is realized by the following technical scheme.
A virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 1-2 parts of hydrogen peroxide, 900 parts of absolute ethyl alcohol 700-.
Preferably, the virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 1-2 parts of hydrogen peroxide, 850 parts of anhydrous ethanol, 30-40 parts of propylene glycol, 14-18 parts of alkyl glycoside, 8-12 parts of cocamidopropyl betaine, 13-18 parts of glycerol, 3-7 parts of citric acid and 300 parts of purified water.
Preferably, the virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 2 parts of hydrogen peroxide, 800 parts of absolute ethyl alcohol, 35 parts of propylene glycol, 16 parts of alkyl glycoside, 10 parts of cocamidopropyl betaine, 15 parts of glycerol, 5 parts of citric acid and 200 parts of purified water.
Specifically, the content of the effective components of the hydrogen peroxide is more than or equal to 30 percent, the content of nonvolatile matters is less than or equal to 0.005 percent, and the content of heavy metals is less than or equal to 0.001 percent by mass.
Specifically, the solid content of the alkyl glycoside is 50%, the content of inorganic salt is less than or equal to 4%, the pH value is 11.5-12.5, the active matter content of cocamidopropyl betaine is 28-32%, and the content of free amine is less than or equal to 2.0% by mass.
The invention also provides a preparation method of the virus-killing hand-washing-free disinfectant as claimed in claim 1, which is characterized by comprising the following operation steps:
(1) dissolving: adding propylene glycol into a reaction kettle with a stirrer, adding hydrogen peroxide into the reaction kettle, and stirring at a constant speed to fully fuse the propylene glycol and the hydrogen peroxide;
(2) mixing: adding absolute ethyl alcohol and purified water into a reaction kettle slowly, and stirring at a constant speed;
(3) adding a surfactant: adding alkyl glycoside and cocamidopropyl betaine into a reaction kettle, and stirring at a constant speed;
(4) adding auxiliary materials: adding glycerol into a reaction kettle, and stirring at a constant speed;
(5) adjusting the pH value: adding citric acid, and measuring the pH value while adding the citric acid to make the pH value close to neutral;
(6) making into final product, and packaging.
Specifically, the rotation speed of uniform stirring in the steps (1) to (4) is 2500r/min, the time of uniform stirring in the steps (1) and (2) is 20-30min, and the time of uniform stirring in the steps (3) and (4) is 10-20 min.
According to the technical scheme, the beneficial effects of the invention are as follows:
1) the disinfectant contains disinfectant components, can kill intestinal pathogenic bacteria, pyogenic coccus, pathogenic yeast and common nosocomial infection bacteria, is prepared by compounding two or more main disinfectant components, and is added with proper stabilizing agent and surfactant, so that the product has high stability, strong bactericidal effect and good bactericidal effect;
2) the disinfectant contains antiviral components, can inactivate viruses, and solves the problem that the common disinfectant cannot inactivate the viruses;
3) the alkyl glycoside and the cocamidopropyl betaine are added and used in a matching way, so that the foaming performance and the moisturizing performance of the hand-washing-free disinfectant are more excellent, the hand feeling is comfortable when the hand-washing-free disinfectant is used, the hand drying and cracking condition of medical staff is reduced, and the hand health of the medical staff is protected;
4) the neutral pH value formula is close to the pH value of hand skin, has better fusion with the hand skin and has no damage to the hand skin;
5) the washing is avoided, the time of medical care personnel is saved, and all the added components are non-toxic and harmless to the human body, and are volatilized quickly and have no residue;
6) the hand-washing-free disinfectant provided by the invention is packaged into various specifications according to market demands, and is suitable for various departments; the product packaging bottle is convenient and quick to use for a user and is not wasted.
7) According to the preparation method provided by the invention, the auxiliary material glycerol is added after the active ingredients in the hand sanitizer are added, so that the stability of the finished product of the hand-washing-free disinfectant can be effectively improved.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The conditions used in the examples may be further adjusted according to the manufacturer's conditions, and the unexplained conditions are generally conventional experimental conditions.
Example 1
A virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 1 part of hydrogen peroxide, 700 parts of absolute ethyl alcohol, 20 parts of propylene glycol, 10 parts of alkyl glycoside, 5 parts of cocamidopropyl betaine, 10 parts of glycerol, 1 part of citric acid and 100 parts of purified water.
Example 2
A virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 2 parts of hydrogen peroxide, 900 parts of absolute ethyl alcohol, 50 parts of propylene glycol, 20 parts of alkyl glycoside, 15 parts of cocamidopropyl betaine, 20 parts of glycerol, 10 parts of citric acid and 300 parts of purified water.
Example 3
A virus-killing hand-washing-free disinfectant is prepared from the following components in parts by weight: 2 parts of hydrogen peroxide, 800 parts of absolute ethyl alcohol, 35 parts of propylene glycol, 16 parts of alkyl glycoside, 10 parts of cocamidopropyl betaine, 15 parts of glycerol, 5 parts of citric acid and 200 parts of purified water.
Comparative example 1
The hand-free disinfection solution is not added with alkyl glycoside, and the rest components are completely the same as the components in the example 1.
Comparative example 2
The hand-free disinfection solution is not added with cocamidopropyl betaine, and the rest components are completely the same as those in the example 2.
Example 4
A preparation method of a virus-killing hand-washing-free disinfectant comprises the following operation steps:
(1) dissolving: adding propylene glycol into a reaction kettle with a stirrer, adding hydrogen peroxide into the reaction kettle, and stirring at a constant speed to fully fuse the propylene glycol and the hydrogen peroxide;
(2) mixing: adding absolute ethyl alcohol and purified water into a reaction kettle slowly, and stirring at a constant speed;
(3) adding a surfactant: adding alkyl glycoside and cocamidopropyl betaine into a reaction kettle, and stirring at a constant speed;
(4) adding auxiliary materials: adding glycerol into a reaction kettle, and stirring at a constant speed;
(5) adjusting the pH value: adding citric acid, and measuring the pH value while adding the citric acid to make the pH value close to neutral;
(6) making into final product, and packaging.
Further, the rotation speed of uniform stirring in the steps (1) to (4) is 2500r/min, the time of uniform stirring in the steps (1) and (2) is 25min, and the time of uniform stirring in the steps (3) and (4) is 15 min.
Comparative example 3
A preparation method of a virus-killing hand-washing-free disinfectant comprises the following operation steps:
(1) dissolving: adding propylene glycol into a reaction kettle with a stirrer, adding hydrogen peroxide into the reaction kettle, and stirring at a constant speed to fully fuse the propylene glycol and the hydrogen peroxide;
(2) mixing: adding absolute ethyl alcohol and purified water into a reaction kettle slowly, and stirring at a constant speed;
(3) adding a surfactant and auxiliary materials: adding alkyl glycoside, cocamidopropyl betaine and glycerol into a reaction kettle, and stirring at a constant speed;
(4) adjusting the pH value: adding citric acid, and measuring the pH value while adding the citric acid to make the pH value close to neutral;
(5) making into final product, and packaging.
Further, the rotation speed of uniform stirring in the steps (1) to (3) is 2500r/min, the time of uniform stirring in the steps (1) and (2) is 25min, and the time of uniform stirring in the step (3) is 15 min.
The hand-free disinfection solution is prepared by the method of example 4 according to the formula of the virus-killing hand-free disinfection solution in examples 1-3 and comparative examples 1-2.
Firstly, acute toxicity test:
a one-time maximum test method is adopted, a dose group and a control group of 5000mg/(kg.bw) are set, and 20 KM mice and SD rats are respectively female and male. The general condition, toxic symptom and death condition of animals are observed after the animals are infected with the toxin by oral gavage once. If the animal dies, dissecting and exploring in time; after 2 weeks the remaining rats were sacrificed under anaesthesia and dissected for exploration. Calculation of LD from animal mortality50。
In the acute toxicity test of the hand-washing-free disinfectant in each example and comparative example, the tested animals have no toxic reaction and death, and the acute oral LD50All are more than 5000mg/(kg.bw), and belong to the actual nontoxic grade.
II, microorganism killing effect experiment:
the hand-washing-free disinfectant prepared in examples 1 to 3 and comparative examples 1 to 2 was tested for its bactericidal rate and bactericidal effect against staphylococcus aureus, escherichia coli and candida albicans for 1min according to the method in the "disinfection technical specification" (2002 edition) issued by the ministry of health of the people's republic of China, and the test results are shown in table 1:
as can be seen from Table 1, the hand sanitizer prepared by the invention has remarkable sterilizing effect and excellent quality.
Third, testing foaming ability and moisture retention
The foaming capacity is measured by adopting an oscillation method: (1) adding 0.5ml of newly prepared hand-washing-free disinfectant into a plastic measuring cylinder, adding 20ml of distilled water, plugging the plastic measuring cylinder by a rubber plug with a proper size, and fully shaking for 20 times, wherein the direction, speed, force and temperature environment are required to be consistent during shaking; (2) immediately taking off the rubber plug after shaking, adding 20ml of water, flushing down the foam in the plastic measuring cylinder along the pipe wall, and recording the height of the foam after shaking and the time required for the foam to be damaged to half of the original height after adding water; (3) the above operations are repeated, and data is recorded. Foam height is used as a measure of the lathering performance of the hand sanitizer and the stability of the foam is characterized by the time it takes for the foam to collapse to half its original height.
Moisture retention measurement: weighing the prepared hand-washing-free disinfectant, taking glycerol as a positive control, then putting the hand-washing-free disinfectant into a prepared saturated ammonium sulfate solution (the relative humidity is 80%) and a prepared saturated potassium acetate solution (the relative humidity is 40%), putting the hand-washing-free disinfectant into a thermostat (25 ℃) for weighing at different times, and A0Representing the initial hand cleanser mass, weighing Ax (6,12,24,36 and 48h) respectively, and calculating as moisture retention (%) -Ax/A0×100％。
The test results are shown in table 2:
as shown in Table 2, the non-washing hand sanitizer prepared by using the alkyl glycoside and the cocamidopropyl betaine has more excellent foaming capacity and moisturizing performance.
Fourth, stability test
The hand-washing-free disinfectant is prepared by the processes of example 4 and comparative example 3 respectively by using the hand-washing-free disinfectant component of example 1, and then stability test is carried out.
And (4) centrifugal test, namely taking a hand-washing-free disinfectant sample and placing the hand-washing-free disinfectant sample in a clean centrifugal tube. The temperature of the centrifuge is controlled at 4 ℃ to carry out a centrifugation test (2000r/min), the centrifuge is centrifuged for 20min, and whether the characters of the hand-free disinfectant have obvious changes or the phenomenon of oil-water separation is observed.
The test results are shown in table 3:
| item | Stability situation |
| Example 4 | No obvious change in properties and no oil-water separation |
| Comparative example 3 | The obvious phenomenon of oil-water separation appears |
As can be seen from table 2, in the preparation process of the hand-washing-free disinfectant provided by the invention, the auxiliary material glycerol is added after the active component in the hand sanitizer is added, so that the stability of the finished product of the hand-washing-free disinfectant can be effectively improved.
Although the present application has been described with reference to a few embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the application as defined by the appended claims.
Claims (7)
1. The virus-killing hand-washing-free disinfectant is characterized by being prepared from the following components in parts by weight: 1-2 parts of hydrogen peroxide, 900 parts of absolute ethyl alcohol 700-.
2. The virus-killing hand-washing-free disinfectant as claimed in claim 1, which is prepared from the following components in parts by weight: 1-2 parts of hydrogen peroxide, 850 parts of anhydrous ethanol, 30-40 parts of propylene glycol, 14-18 parts of alkyl glycoside, 8-12 parts of cocamidopropyl betaine, 13-18 parts of glycerol, 3-7 parts of citric acid and 300 parts of purified water.
3. The virus-killing hand-washing-free disinfectant as claimed in claim 1, which is prepared from the following components in parts by weight: 2 parts of hydrogen peroxide, 800 parts of absolute ethyl alcohol, 35 parts of propylene glycol, 16 parts of alkyl glycoside, 10 parts of cocamidopropyl betaine, 15 parts of glycerol, 5 parts of citric acid and 200 parts of purified water.
4. The virus-killing hand-washing-free disinfectant as claimed in any one of claims 1-3, wherein the content of the effective component of hydrogen peroxide is more than or equal to 30%, the content of non-volatile matter is less than or equal to 0.005%, and the content of heavy metal is less than or equal to 0.001% by mass.
5. A virus-killing hand-washing-free disinfectant as claimed in any one of claims 1-3, wherein the alkyl glycoside has a solid content of 50%, an inorganic salt content of 4% or less, a pH value of 11.5-12.5, a cocamidopropyl betaine active content of 28-32%, and a free amine content of 2.0% or less, by mass.
6. The preparation method of the virus-killing hand-washing-free disinfectant as claimed in claim 1, which comprises the following steps:
(1) dissolving: adding propylene glycol into a reaction kettle with a stirrer, adding hydrogen peroxide into the reaction kettle, and stirring at a constant speed to fully fuse the propylene glycol and the hydrogen peroxide;
(2) mixing: adding absolute ethyl alcohol and purified water into a reaction kettle slowly, and stirring at a constant speed;
(3) adding a surfactant: adding alkyl glycoside and cocamidopropyl betaine into a reaction kettle, and stirring at a constant speed;
(4) adding auxiliary materials: adding glycerol into a reaction kettle, and stirring at a constant speed;
(5) adjusting the pH value: adding citric acid, and measuring the pH value while adding the citric acid to make the pH value close to neutral;
(6) making into final product, and packaging.
7. The method for preparing a virus-killing hand-washing-free disinfectant as claimed in claim 6, wherein the rotation speed of the uniform stirring in the steps (1) to (4) is 2500r/min, the time of the uniform stirring in the steps (1) and (2) is 20-30min, and the time of the uniform stirring in the steps (3) and (4) is 10-20 min.
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Cited By (5)
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| CN113304060A (en) * | 2021-05-28 | 2021-08-27 | 浙江国药景岳气雾剂有限公司 | No-clean type slow-release hydrogen peroxide sterilization hand sanitizer and preparation method thereof |
| CN114668702A (en) * | 2022-02-25 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant and preparation method thereof |
| CN114668680A (en) * | 2022-03-15 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant capable of killing viruses |
| CN114767712A (en) * | 2022-04-25 | 2022-07-22 | 杭州西子卫生消毒药械有限公司 | Low-volatility disinfectant and preparation method thereof |
| CN116195594A (en) * | 2022-12-30 | 2023-06-02 | 广东红日星实业有限公司 | Disinfection cleaning agent and preparation method and application thereof |
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2020
- 2020-03-11 CN CN202010167424.2A patent/CN111228304A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113304060A (en) * | 2021-05-28 | 2021-08-27 | 浙江国药景岳气雾剂有限公司 | No-clean type slow-release hydrogen peroxide sterilization hand sanitizer and preparation method thereof |
| CN113304060B (en) * | 2021-05-28 | 2022-07-08 | 浙江国药景岳气雾剂有限公司 | No-clean type slow-release hydrogen peroxide sterilization hand sanitizer and preparation method thereof |
| CN114668702A (en) * | 2022-02-25 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant and preparation method thereof |
| CN114668702B (en) * | 2022-02-25 | 2023-08-01 | 湖北微控生物科技有限公司 | No-wash quick-drying hand sanitizer and preparation method thereof |
| CN114668680A (en) * | 2022-03-15 | 2022-06-28 | 湖北微控生物科技有限公司 | Washing-free quick-drying hand disinfectant capable of killing viruses |
| CN114767712A (en) * | 2022-04-25 | 2022-07-22 | 杭州西子卫生消毒药械有限公司 | Low-volatility disinfectant and preparation method thereof |
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