CN111184658A - Hand disinfectant and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of disinfectant, and discloses a hand disinfectant and a preparation method thereof, wherein the specific method comprises the following steps: preparing raw materials in parts by weight; dissolving polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution; adding purified ionized water to full volume, and performing constant volume and aging; inspecting the obtained intermediate product; if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product; and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse. The disinfectant disclosed by the invention has the excellent characteristics of broad sterilization spectrum, low effective concentration, high action speed and high water solubility, can be used at normal temperature, is bacteriostatic for a long time, has no side effect, is non-corrosive, and is clean and degreased; the use is safe; the price is moderate, and the transportation is convenient; has no irritation to skin, has effects of moistening skin and retaining water, and has strong disinfection and sterilization capability and high stability.

Description

Hand disinfectant and preparation method thereof

Technical Field

The invention belongs to the technical field of disinfectant, and particularly relates to a hand disinfectant and a preparation method thereof.

Background

The living standard of people is continuously improved, and the awareness of health consciousness and disease prevention is gradually enhanced. The hands of people are in direct and frequent contact with articles, and various microorganisms such as bacteria, viruses and the like are carried on the skin of the hands. These bacteria may not only infect the person themselves, but may also be transmitted to others by means of a handshake, contact with other objects such as a telephone, a door handle, etc. Especially, the patients experience infectious atypical pneumonia, avian influenza, hand-foot-and-mouth disease and influenza A H1N1, people have good understanding on the application of the disinfectant, and the market demand of hand disinfection products is increased.

At present, the common hand disinfectants are various, and mainly comprise iodophor, ethanol, chlorhexidine (chlorhexidine), high oxidation-reduction potential water, chlorine-containing disinfectant, other compound disinfectant and the like. These disinfectants have ideal effects in disinfection and sterilization, but have irritation or other side effects on hand skin, easily cause hand skin to be dry, rough and chapped after long-term use, and have short disinfection and sterilization effect retention time.

In summary, the existing disinfectant has ideal disinfection and sterilization effects, but has irritation or other side effects on hand skin, is easy to dry, rough and chap the hand skin after long-term use, and has short disinfection and sterilization effect retention time.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a hand disinfectant and a preparation method thereof.

The hand disinfectant is prepared from, by weight, 0.5-0.55% of polyhexamethylene guanidine hydrochloride, 0.8% of p-hydroxybenzoate with the purity of 99%, 0.03% of fatty alcohol-polyoxyethylene ether, 0.1% of hydroxypropyl methyl cellulose, 0.05% of peppermint oil, 1.5% of glycerol and the balance of purified deionized water, wherein the balance is supplemented to 100%.

Furthermore, the purity of the polyhexamethylene guanidine hydrochloride is 95%, the purity of the p-hydroxybenzoate is 99%, the purity of the fatty alcohol-polyoxyethylene ether is 99%, the purity of the hydroxypropyl methyl cellulose is 99%, the purity of the peppermint oil is 50% and the purity of the glycerol is 99%.

Furthermore, each 1000kg of the hand disinfectant consists of 5kg of 95% purity polyhexamethylene guanidine hydrochloride, 8kg of 99% purity p-hydroxybenzoate, 0.3kg of 99% purity fatty alcohol-polyoxyethylene ether, 1kg of 99% purity hydroxypropyl methyl cellulose, 0.5kg of 50% purity peppermint oil, 15kg of 99% purity glycerin and the balance of purified deionized water.

Another object of the present invention is to provide a method for preparing the hand sanitizer, which comprises the following steps:

preparing raw materials in parts by weight: 0.5-0.55% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.8% of p-hydroxybenzoate with the purity of 99%, 0.03% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.1% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 1.5% of glycerol with the purity of 99%, and the balance of purified deionized water;

dissolving polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution;

adding purified deionized water to full volume, and performing constant volume and aging;

step four, inspecting the obtained intermediate product;

step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.

The invention aims to improve the stimulation or other side effects of the disinfectant on hand skin, increase the skin-care and water-retention functions and simultaneously keep the disinfection and sterilization effects for a longer time.

The invention is realized by the following main components of polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerin, and is characterized by containing the polyhexamethylene guanidine hydrochloride, and the mechanism is as follows: (1) guanidine compounds have higher activity, polymers are electropositive, and various bacteria and viruses are easy to adsorb because of electronegativity, so that the bacteria and the viruses cannot divide and reproduce and lose activity; (2) the structure of the cell membrane is collapsed to form a transmembrane pore, the cell membrane is broken to destroy the energy metabolism of the microorganism, and the activity of the bacterial virus is lost; (3) the polymer can form a layer of film to seal the breathing channel of the microorganism, so that the microorganism is suffocated; the sterilization mechanism is independent of the form and the species of the microorganism, the effect of the microorganism cannot be influenced even if the microorganism is variant or variant, and the microorganism does not generate drug resistance to the polyhexamethylene guanidine salt; the fatty alcohol-polyoxyethylene ether has the main functions of improving the affinity of oil stain and water and providing detergency, and has the characteristics of good detergency, insensitivity to hard water, small foam and the like as a nonionic surfactant; the hydroxypropyl methyl cellulose has the main functions of an emulsifier, a thickener and a dispersant, so that the disinfectant is more viscous as a whole, and the components are well and uniformly dispersed; the mint oil has the main function of repelling mosquitoes, and has fresh and comfortable smell; the main function of the glycerin is to moisten the skin and retain water; water is the solvent.

The raw materials of the invention are respectively polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol, and the purified deionized water is used as a solvent. In view of the above, the above ingredients need to be prepared as homogeneous solutions, and therefore good water solubility is required, adverse reaction or adverse effect cannot occur between the components, so that each component can respectively play the due role, for example, the polyhexamethylene guanidine hydrochloride has good water solubility and obvious bactericidal effect, the recommended dosage of different purposes of various manufacturers is considered, the recommended dosage of personal care products such as antibacterial fabrics is 0.3-0.6 percent, the recommended dosage of wet tissue products such as non-woven fabrics or wet towels is 0.2-0.3 percent, the recommended dosage of mixed aqueous solution is 0.05-0.5 percent, the recommended dosage and the application object of the invention are hand skin, the hand skin is usually wiped after the hand skin is soaked by the fabrics such as wet towels and the like, or hands are directly immersed in the disinfection diluent, so that the use amount of the solution is proper, and the use amount range of the polyhexamethylene guanidine hydrochloride used in the invention is proper from 0.5% to 0.55%; the p-hydroxybenzoate has a phenolic hydroxyl structure, has strong antibacterial property, can destroy cell membranes of microorganisms, denature proteins in cells, and inhibit activities of a respiratory enzyme system and an electron transfer enzyme system of the microorganism cells, and the common addition amount is controlled within the range of 0.8-1.5 percent, so that the p-hydroxybenzoate serving as the hand sanitizer is used as the hand sanitizer, the addition amount does not need to be increased, and the addition amount is low, so that the addition amount is 0.8 percent; the fatty alcohol-polyoxyethylene ether is a good nonionic surfactant, has the characteristics of degreasing, safety, no toxicity, no irritation to skin, small foam generation amount, insensitivity to hard water and the like, is good in water solubility, easy to rinse and easy to mix with other substances, and usually the surfactant plays roles of sterilization, synergism, emulsification, foaming and the like in a disinfectant, and the dosage is usually not more than 1%, so that the dosage of the surfactant is reduced and is more suitable for selecting 0.03% in consideration of the action object of the hand sanitizer without foaming or emulsifying effect and washing the hand skin with clean water again after disinfecting; hydroxypropyl methylcellulose is a good dispersing agent and thickening agent, although the water solubility is slightly poor, the hydroxypropyl methylcellulose can be completely dissolved in water by a proper dissolving method, so that the system viscosity is increased while the uniform dispersion of the system is assisted, and the thickening effect is extremely obvious, and the sanitation standard is not described in the addition of hydroxypropyl methylcellulose, so that the dispersing and thickening purposes can be realized by using a trace amount of hydroxypropyl methylcellulose, and 0.1 percent of hydroxypropyl methylcellulose is selected as a using amount; the peppermint oil is colorless or light yellow clear liquid, has good water solubility and special cool fragrance, can kill insects and mites, has the effect of refreshing and restoring consciousness, is usually used as an additive, does not specifically describe the peppermint oil according to various technical requirements, is usually used as the additive by referring to patents or description conditions of other disinfection products, has the addition amount of 0.02-2 percent, and is suitable for using a lower addition amount in consideration of the action object of the peppermint oil, so 0.05 percent is selected as the addition amount; the glycerin is chemically named as glycerol, is miscible with water in any proportion, has the effects of water retention and skin moistening, is commonly used as an additive in detergents, cosmetics and medicines by referring to patents or descriptions of other disinfection products, and is usually added in an amount of 1-5%. By combining the characteristics of the components, the water solubility can meet the requirements, no incompatibility occurs between the components, no adverse reaction or adverse effect occurs, the components can respectively play the roles of respective fields, and a homogeneous solution with the expected effect can be obtained.

The disinfectant disclosed by the invention belongs to an environment-friendly high-molecular polymer sterilization disinfectant, the main component of the disinfectant is polyhexamethylene guanidine, the disinfectant has the excellent performances of broad sterilization spectrum, low effective concentration, high action speed and water solubility, can be used at normal temperature, is bacteriostatic for a long time, has no side effect, is non-corrosive, has fresh and comfortable smell, and is clean and degreased; the paint is non-toxic, non-combustible and non-explosive, and is safe to use; the price is moderate, and the transportation is convenient; has no irritation to skin, has effects of moistening skin and retaining water, and has strong disinfection and sterilization capability and high stability. The hand disinfectant disclosed by the invention has the advantages of lasting effect and good disinfection and sterilization effects, has the effects of moisturizing skin, cooling and expelling parasites, and solves the problem that the hand skin is easy to dry, rough and chap after long-term use of the existing disinfectant.

Drawings

Fig. 1 is a flowchart of a method for preparing a hand sanitizer according to an embodiment of the present invention.

Fig. 2 is a flow chart of a production process of the hand sanitizer provided in the embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The technical scheme of the invention is described in detail in the following with reference to the accompanying drawings.

The hand disinfectant provided by the embodiment of the invention comprises, by weight, 0.5% -0.55% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.8% of p-hydroxybenzoate with the purity of 99%, 0.03% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.1% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 1.5% of glycerin with the purity of 99%, and the balance of purified deionized water, wherein the deionized water is used for supplementing to 100%.

Every 1000kg of the hand disinfectant provided by the embodiment of the invention consists of 5kg of polyhexamethylene guanidine hydrochloride with the purity of 95%, 8kg of p-hydroxybenzoate with the purity of 99%, 0.3kg of fatty alcohol-polyoxyethylene ether with the purity of 99%, 1kg of hydroxypropyl methyl cellulose with the purity of 99%, 0.5kg of peppermint oil with the purity of 50%, 15kg of glycerin with the purity of 99%, and the balance of purified deionized water.

In a preferred embodiment of the invention, polyhexamethyleneguanidine hydrochloride, parabens, fatty alcohol-polyoxyethylene ether, hydroxypropyl methylcellulose, parabens, peppermint oil, glycerin are technical grade.

As shown in fig. 1, the preparation method of the hand sanitizer provided by the embodiment of the present invention includes the following steps:

s101: preparing raw materials in parts by weight: 0.5-0.55% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.8% of p-hydroxybenzoate with the purity of 99%, 0.03% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.1% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 1.5% of glycerol with the purity of 99%, and the balance of purified deionized water;

s102: dissolving polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution;

s103: adding purified deionized water to full volume, and performing constant volume and aging;

s104: inspecting the obtained intermediate product;

s105: if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

s106: and (5) inspecting the finished product, and storing the qualified product in a finished product warehouse.

The technical solution of the invention is further described below with reference to specific embodiments.

Example (b):

the prescription of 1000kg of the product comprises:

and (3) a disinfection effect test, namely uniformly coating the bacteria liquid to be tested on the surface of the medical instrument, putting a drop (0.05ml) of the bacteria liquid to be tested into a culture medium flat plate for culture, and quickly coating the surface of the instrument with the disinfectant. 1 drop (0.05ml) of the solution was scraped from the surface of the device after 15min and after 200min, respectively, and incubated in a plate. And respectively culturing the bacterial liquids for 48 hours under the condition of proper temperature of each bacterium during the plate culture period, respectively counting, and calculating the bacterial colony killing rate after coating the disinfectant for 15min and 200 min.

The disinfection effect of the disinfectant of the invention

As can be seen from the table above, the compound bactericide can effectively kill staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, candida albicans and the like, and the inhibition rate reaches over 98.5% after 15min and 200min of disinfection. From the aspect of disinfection time, the disinfectant has lasting action time, and the bacterial colony killing degrees of 15min and 200min are not greatly different. The product has the following experimental and performance test results:

list of polyhexamethylene guanidine toxicities

In situ sterilization test

Polyhexamethylene guanidine stability

Comparison of various disinfectant products

In conclusion, the disinfectant disclosed by the invention belongs to an environment-friendly high-molecular polymer sterilization disinfectant, the main component of the disinfectant is polyhexamethylene guanidine, the disinfectant has the excellent performances of broad sterilization spectrum, low effective concentration, high action speed and water solubility, can be used at normal temperature, has the effects of inhibiting bacteria for a long time, has no side effect, is free of corrosiveness, is fresh and comfortable in smell, and is clean and degreased; the paint is non-toxic, non-combustible and non-explosive, and is safe to use; the price is moderate, and the transportation is convenient; has no irritation to skin, has effects of moistening skin and retaining water, and has strong disinfection and sterilization capability and high stability. The hand disinfectant disclosed by the invention has the advantages of lasting effect and good disinfection and sterilization effects, has the effects of moisturizing skin, cooling and expelling parasites, and solves the problem that the hand skin is easy to dry, rough and chap after long-term use of the existing disinfectant.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (5)

1. The hand disinfectant is characterized by comprising, by weight, 0.5% -0.55% of polyhexamethylene guanidine hydrochloride, 0.5% of p-hydroxybenzoate, 0.03% of fatty alcohol-polyoxyethylene ether, 0.1% of hydroxypropyl methyl cellulose, 0.05% of peppermint oil, 1.5% of glycerol and the balance of purified deionized water, wherein the deionized water is supplemented to 100%.

2. The hand sanitizer of claim 1, wherein the polyhexamethyleneguanidine hydrochloride has a purity of 95%, the paraben has a purity of 99%, the fatty alcohol-polyoxyethylene ether has a purity of 99%, the hydroxypropyl methylcellulose has a purity of 99%, the peppermint oil has a purity of 50%, and the glycerin has a purity of 99%.

3. The hand sanitizer of claim 1, wherein each 1000kg of the hand sanitizer comprises 95% pure polyhexamethylene guanidine hydrochloride 5kg, 99% pure paraben 8kg, 99% pure fatty alcohol-polyoxyethylene ether 0.3kg, 99% pure hydroxypropyl methylcellulose 1kg, 50% pure peppermint oil 0.5kg, 99% pure glycerin 15kg, and the balance purified deionized water.

4. A method for preparing the hand sanitizer according to claim 1, comprising the steps of:

preparing raw materials in parts by weight: 0.5-0.55% of polyhexamethylene guanidine hydrochloride with the purity of 95%, 0.8% of p-hydroxybenzoate with the purity of 99%, 0.03% of fatty alcohol-polyoxyethylene ether with the purity of 99%, 0.1% of hydroxypropyl methyl cellulose with the purity of 99%, 0.05% of peppermint oil with the purity of 50%, 1.5% of glycerol with the purity of 99%, and the balance of purified deionized water;

dissolving polyhexamethylene guanidine hydrochloride, p-hydroxybenzoate, fatty alcohol-polyoxyethylene ether, hydroxypropyl methyl cellulose, peppermint oil and glycerol in purified deionized water, and stirring to obtain a homogeneous solution;

adding purified deionized water to full volume, and performing constant volume and aging;

step four, inspecting the obtained intermediate product;

step five, if the product is qualified, filling and sealing the product by using disinfectant plastic bottles and heads, and externally packaging the product;

and step six, inspecting the finished products, and storing the qualified products in a finished product warehouse.

5. A disinfectant liquid prepared from the hand disinfectant liquid according to any one of claims 1 to 3.

Images