CN103948520A - Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same - Google Patents
Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same Download PDFInfo
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- CN103948520A CN103948520A CN201410175093.1A CN201410175093A CN103948520A CN 103948520 A CN103948520 A CN 103948520A CN 201410175093 A CN201410175093 A CN 201410175093A CN 103948520 A CN103948520 A CN 103948520A
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Abstract
The invention discloses a guanidyl composite disinfection and cleaning hand sanitizer and a preparation method for the same. The hand sanitizer comprises the following chemical compositions: polyhexamethylene biguanidine hydrochloride, polyoxyethylene octylphenol ether, fatty alcohol-polyoxyethylene ether, polyethylene glycol, propylene glycol and deionized water. The preparation method for the hand sanitizer comprises the following steps of adding deionized water in a container, heating, and then adding a polyhexamethylene biguanidine hydrochloride aqueous solution to obtain a pre-solution; sequentially adding polyoxyethylene octylphenol ether, fatty alcohol-polyoxyethylene ether, polyethylene glycol and propylene glycol in the pre-solution to obtain a basic solution; adding all of the residual deionized water in the basic solution to prepare the disinfection and cleaning hand sanitizer. The hand sanitizer disclosed by the invention is high in sterilization effect, high in safety and more stable in properties, and has a skin care function; the product is a colorless clear liquid in character, and is not changed in color in long-time storage.
Description
Technical field
The present invention relates to disinfecting cleaning handwashing liquid and preparation method thereof, particularly a kind of guanidine radicals disinfecting cleaning handwashing liquid and preparation method thereof.
Background technology
Hands be in human body, contact at most with the external world, be also the dirtiest position, usually can be with various pathogenic bacterias on the surface of hands.On the one hand, people are in daily life work, and both hands can inevitably contact with microorganism, the even article of pathogenic microorganism, thus make both hands bacterial infection.On the one hand, because chance and the approach of the public contacts of modern society people increase, in public arenas such as family, hotel, restaurant, airport, station and hospitals, people also increase by the chance of hands bacteria infection in addition.Especially medical personnel, in the diagnosis and treatment to patient, nursing, health check-up and the work such as change dressings, handle cause directly and the courses of infection of indirect occupy first place.Epidemiological study confirms, more than 98% medical worker's the severe overweight of antibacterial on hand has more universality and danger by doctor and nurse's hands approach direct or infect indirectly antibacterial than air borne.Therefore keep the sanitation and hygiene of hand, to prevent disease, ensure healthy having very important significance.
The health of hand is closely bound up with everyone daily life, and about 80% universality communicate illness is all directly propagated and caused by both hands, so the approach of effectively preventing pathophoresis is exactly to do good hand's sterilization.Holding this pass of washing one's hands and be ensureing healthy important means, is also control pathophoresis and protect from infection the most effectively and the most simple method, and therefore people are also more and more stronger to having the requirement of handwashing liquid of disinfecting and sterilizing functions.Handwashing liquid is as the daily articles for washing of one, has performance gentleness, chafe, easy to use, anti-hard water, easy cleaning, foam are abundant and wash the features such as rear skin lubrication sense is good.In the functional type handwashing liquid of selling at present in China, disinfection series products is a class of sales volume maximum, is accepted by increasing consumer now, and has entered into huge numbers of families.
The time that handwashing liquid stops in hands is not long, in the shorter time, reach disinfecting, antimicrobial effect, should select the disinfectant that sterilization speed is fast, disinfection efficacy strong, skin is had no stimulation to add in handwashing liquid.Anti-bacterial hand lotion in the market all adopts the chloro-2-of 2,4,4-tri-to make antibacterial through chloride products such as base phenylate, xylene chloride phenol and triclosans mostly, and kind is more single, and permanent use is gone down, and easily produces drug resistance.In addition, due to the unhappy abnormal smells from the patient of chlorine self, the impact that there is stronger corrosivity and environment is caused, chlorine-containing disinfectant finally will be withdrawn from the market.And hexamethylene (PHMB) has the bactericidal range of wide spectrum, lower effective working concentration, bactericidal action is rapid, stable in properties, premium properties soluble in water; Can use at normal temperatures, can be long-term antibacterial and have no side effect, non-corrosiveness and toxicity, non-stimulated; Nonflammable and blast, use safe and reliable, environmentally safe.PHMB is as the disinfectant of a class new green environment protection type, has that sterilization speed is fast, disinfection efficacy strong, a feature non-stimulated to skin, can add to completely in handwashing liquid.This product directly acts on hand as hand disinfectant, no matter when and where, all can be safely, kill effectively, expediently pathogen on hand fast, do not need soap and water, just can form the water white stealthy thin film of one deck on the surface of hands, keep antibacterial, bactericidal effect for a long time.
Along with the enhancing of people's health care consciousness and the pursuit of concept of health, make people more and more pay close attention to the healthy of oneself.Therefore studying a kind of potent disinfecting cleaning handwashing liquid that had not only had dirt-removing functions but also can kill hand microorganism simultaneously has great importance.
Consult existing correlation technique data, relate at present the hand cleanser products and the technology that contain PHMB and mainly contain following several:
(1) Chinese patent open (bulletin) number: CN101548983A discloses a kind of skin antiseptic and preparation method thereof; CN101912409A discloses a kind of aerial fog disinfectant and preparation method; CN102265894A discloses a kind of composition and method of making the same of killing microorganisms, in these three formulas, although selected hexamethylene as disinfectant, but in formula owing to adding a large amount of ethanol, have very strong sharp aroma, life-time service also can cause hand skin allergy, coarse, dry and cracked and decortication problem.
(2) Chinese patent open (bulletin) number: CN1476761A discloses a kind of efficient liquid disinfectant and preparation method thereof; CN1786134A discloses a kind of multifunction antiseptic sterilizing cleaning agent composition and preparation method thereof, adopts 3 kinds of disinfectant combined sterilizings, and be equipped with Multiple components in these two formulas.These two kinds of formula material complexity, cost is higher, and contains aldehydes or chlorine class disinfectant in formula, and abnormal smells from the patient is large, and human body skin, mucosa are had to serious stimulation, and life-time service can cause skin allergy phenomenon, and residual serious, to environment.
(3) Chinese patent open (bulletin) number: CN101684435A discloses a kind of disinfection hand cleanser and preparation method thereof; CN102018634A discloses a kind of compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method thereof; CN101810186A discloses a kind of multifunctional disinfectant and preparation method thereof, and these three kinds formula Raw compositions are more, and preparation process is loaded down with trivial details, complex process, and cost is higher.
At present, in general handwashing liquid, be all taking anion surfactant as main laundry active, and hexamethylene is cationic polymer, has incompatibility with anion.This just makes guanidine class disinfectant can not add the cleaning product the inside taking anion surfactant as main decontamination active component such as handwashing liquid, liquid detergent, liquid detergent to, make the product that can simultaneously complete decontamination and sterilizing effect, this has limited the range of application of guanidine class disinfectant greatly.
And handwashing liquid most products function singleness of the prior art, detergency are strong, cost is more high, some product life-time service also has injury to people's skin.
Summary of the invention
The invention provides clean handwashing liquid of a kind of guanidine radicals compound disinfecting and preparation method thereof, this handwashing liquid does not contain anion surfactant, and has good clean result and fungicidal effectiveness.
The clean handwashing liquid of a kind of guanidine radicals compound disinfecting, its chemical composition and weight percent content are as follows:
The be weight percentage aqueous solution of content 20% of described hexamethylene, pH is 4.0-6.0, colourless transparent liquid; Fatty alcohol-polyoxyethylene ether weight percent content is greater than 99%, is water white transparency thick liquid under room temperature, and pH value is 5.5-7.5; OPEO weight percent content is greater than 99%, is water white transparency thick liquid under room temperature, and pH value is 5.0-7.0.
The clean handwashing liquid of described a kind of guanidine radicals compound disinfecting is transparency liquid.
A preparation method for the clean handwashing liquid of guanidine radicals compound disinfecting, the method comprises the following steps:
A. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned guanidine radicals compound disinfecting, in container, add the 1/5-1/4 of deionized water total amount, and be heated to after 60 DEG C-70 DEG C, add hexamethylene aqueous solution, fully stir, hexamethylene is uniformly dispersed in deionized water, obtains preposition solution;
B. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned guanidine radicals compound disinfecting, in preposition solution, add successively OPEO, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol and propylene glycol, stir, obtain basic solution;
C. in basic solution, add remaining whole deionized water, carry out mix and blend, fully dissolve, make potent disinfecting cleaning handwashing liquid.
The present invention is compared with existing like product and technology, and its significant beneficial effect is embodied in:
1. the present invention, taking hexamethylene, non-ionic surface active agent, Polyethylene Glycol and propylene glycol as raw material, makes sterilization effect stronger, and safety is higher, and character is more stable, has skin care effect simultaneously.
2. PHMB is used for skin degerming by handwashing liquid of the present invention, composite non-ionic surface active agent, and Synergistic, not only strengthens bactericidal effect, and has more increased stability and the dirt-removing power of handwashing liquid, has soft and smooth sensation after rinsing.On the one hand, in this system, add non-ionic surface active agent, made it have good dispersion, emulsifying and osmosis, strengthened sterilization and bacteriostasis effect.On the other hand, in this system, add Polyethylene Glycol, propylene glycol, can after skin surface moisture evaporation, leave layer protecting film, stoped or slowed down the loss of skin internal moisture, kept the wettability of skin.
3. easy cleaning of the present invention, non-stimulated to skin.Because the present invention has adopted hexamethylene, therefore there is no anion surfactant (having incompatibility), the zest of so very big reduction handwashing liquid to skin in formula.In formula, adopt non-ionic surface active agent, thus the foam exquisiteness that handwashing liquid is produced, easy cleaning.
4. handwashing liquid of the present invention, owing to having used hexamethylene to make antibacterial, does not need to add dyestuff, and product characteristics are colourless transparent liquids, long-term storage invariant color.
Verify below by bactericidal assay, stability test the beneficial effect that the present invention produces.
1. bactericidal assay
According to the standard of " disinfection technology standard " (version in 2002), staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, Staphylococcus albus have been done to bactericidal assay, the results are shown in Table 1.
Table 1: bactericidal assay result is pressed killing rate (%)
| Kill mushroom | Staphylococcus aureus | Escherichia coli | Pseudomonas aeruginosa | Staphylococcus albus |
| Killing rate | 100 | 100 | 100 | 100 |
As can be seen from the above table, sterilization functions of the present invention is very strong, and the clean handwashing liquid of guanidine radicals compound disinfecting, to above-mentioned 4 kinds of microbial action 1min, all can reach 100% killing effect.
2. stability test
According to the standard of " disinfection technology standard " (version in 2002), solution of the present invention was put in 37 DEG C of constant incubators after 3 months, staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, Staphylococcus albus are carried out to bactericidal assay, effect 1min, killing rate is all greater than 99.99%.
In sum, the sterilization that the present invention can be widely used in the Related product such as hands, skin is with clean.
Detailed description of the invention
The clean handwashing liquid of a kind of guanidine radicals compound disinfecting, its chemical composition and weight percent content are as follows:
A preparation method for the clean handwashing liquid of guanidine radicals compound disinfecting, the method step is as follows:
A. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned a kind of guanidine radicals compound disinfecting, in container, add the 1/5-1/4 of deionized water total amount, and be heated to 60-70 DEG C, add hexamethylene aqueous solution, fully stir, hexamethylene is uniformly dispersed in deionized water, obtain preposition solution;
B. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned guanidine radicals compound disinfecting, in preposition solution, add successively OPEO, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol and propylene glycol, stir, obtain basic solution;
C. in basic solution, add remaining whole deionized water, carry out mix and blend, fully dissolve, make the clean handwashing liquid of guanidine radicals compound disinfecting.
Claims (3)
1. the clean handwashing liquid of guanidine radicals compound disinfecting, is characterized in that the chemical composition of this handwashing liquid and weight percent content are as follows:
The be weight percentage aqueous solution of content 20% of described hexamethylene, pH is 4.0-6.0, colourless transparent liquid; Fatty alcohol-polyoxyethylene ether weight percent content is greater than 99%, is water white transparency thick liquid under room temperature, and pH value is 5.5-7.5; OPEO weight percent content is greater than 99%, is water white transparency thick liquid under room temperature, and pH value is 5.0-7.0.
2. a kind of guanidine radicals compound disinfecting cleans handwashing liquid according to claim 1, it is characterized in that handwashing liquid is transparency liquid.
3. the preparation method of the clean handwashing liquid of a kind of guanidine radicals compound disinfecting described in claim 1, is characterized in that the method comprises the following steps:
A. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned guanidine radicals compound disinfecting, in container, add the 1/5-1/4 of deionized water total amount, and be heated to after 60 DEG C-70 DEG C, add hexamethylene aqueous solution, fully stir, hexamethylene is uniformly dispersed in deionized water, obtains preposition solution;
B. according to chemical composition and the weight percent content of the clean handwashing liquid of above-mentioned guanidine radicals compound disinfecting, in preposition solution, add successively OPEO, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol and propylene glycol, stir, obtain basic solution;
C. in basic solution, add remaining whole deionized water, carry out mix and blend, fully dissolve, make potent disinfecting cleaning handwashing liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410175093.1A CN103948520A (en) | 2014-04-28 | 2014-04-28 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
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| CN201410175093.1A CN103948520A (en) | 2014-04-28 | 2014-04-28 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN111012957A (en) * | 2019-12-26 | 2020-04-17 | 李春香 | Human body lubricating liquid or lubricating oil capable of quickly killing various viruses and pathogenic bacteria including HIV |
| CN111184658A (en) * | 2020-03-06 | 2020-05-22 | 吉林云飞医药有限公司 | Hand disinfectant and preparation method thereof |
| CN111248228A (en) * | 2020-03-06 | 2020-06-09 | 吉林云飞医药有限公司 | Disinfectant for baby products and preparation method thereof |
| CN111264566A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Household disinfectant and preparation method thereof |
| CN111281880A (en) * | 2020-03-27 | 2020-06-16 | 稳领(天津)医学科技有限公司 | Wound nursing disinfection product |
| CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548983A (en) * | 2009-04-25 | 2009-10-07 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN101810186A (en) * | 2010-05-18 | 2010-08-25 | 北京绿伞化学股份有限公司 | Multifunctional disinfectant and preparation method thereof |
| CN102015986A (en) * | 2008-03-16 | 2011-04-13 | 阿尔托斯医疗有限公司 | Cleaning, sanitising and sterilising preparations |
| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
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2014
- 2014-04-28 CN CN201410175093.1A patent/CN103948520A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102015986A (en) * | 2008-03-16 | 2011-04-13 | 阿尔托斯医疗有限公司 | Cleaning, sanitising and sterilising preparations |
| CN101548983A (en) * | 2009-04-25 | 2009-10-07 | 广西佳华医疗卫生用品有限公司 | Skin disinfectant and method of producing the same |
| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
| CN101810186A (en) * | 2010-05-18 | 2010-08-25 | 北京绿伞化学股份有限公司 | Multifunctional disinfectant and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769608A (en) * | 2016-04-07 | 2016-07-20 | 成都蓝孚科技有限公司 | Sterilization and disinfection hand sanitizer and preparation method thereof |
| CN108403465A (en) * | 2018-04-19 | 2018-08-17 | 山东顺皓聚氨酯保温材料有限公司 | A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof |
| CN111012957A (en) * | 2019-12-26 | 2020-04-17 | 李春香 | Human body lubricating liquid or lubricating oil capable of quickly killing various viruses and pathogenic bacteria including HIV |
| CN111184658A (en) * | 2020-03-06 | 2020-05-22 | 吉林云飞医药有限公司 | Hand disinfectant and preparation method thereof |
| CN111248228A (en) * | 2020-03-06 | 2020-06-09 | 吉林云飞医药有限公司 | Disinfectant for baby products and preparation method thereof |
| CN111264566A (en) * | 2020-03-06 | 2020-06-12 | 吉林云飞医药有限公司 | Household disinfectant and preparation method thereof |
| CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
| CN111281880A (en) * | 2020-03-27 | 2020-06-16 | 稳领(天津)医学科技有限公司 | Wound nursing disinfection product |
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Application publication date: 20140730 |