CN111281880A - Wound nursing disinfection product - Google Patents
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- CN111281880A CN111281880A CN202010228913.4A CN202010228913A CN111281880A CN 111281880 A CN111281880 A CN 111281880A CN 202010228913 A CN202010228913 A CN 202010228913A CN 111281880 A CN111281880 A CN 111281880A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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Abstract
The invention belongs to the field of wound nursing disinfection products, and particularly relates to a wound nursing disinfection product which comprises a cationic bactericide, a high-molecular film-forming material and purified water, wherein the mass concentration range of the cationic bactericide is 0.005-5%, the mass concentration range of the high-molecular film-forming material is 0.01-25%, and the balance of the purified water. The invention provides a long-lasting bacteriostatic agent for killing various pathogenic microorganisms; meanwhile, the wound care disinfectant has the functions of film formation and moisture preservation, can effectively prevent microorganisms from entering the wound, can maintain the moist environment of the wound surface, and can accelerate the healing of the wound.
Description
Technical Field
The invention belongs to the field of wound nursing disinfection products, and particularly relates to a wound nursing disinfection product.
Background
The prior art and the defects are as follows:
the skin is the largest organ of the human body, and can effectively protect the body and resist bacterial invasion and the like in the process of contacting with the external environment. When the skin is damaged by external force, the protective effect of the skin is weakened or disappears; if the wound is not treated in time after the skin is damaged, the symptoms such as bacterial infection, pain, pruritus and the like can be caused in the healing process. The symptoms not only seriously hinder the healing of the wound, but also bring pain to the patient, so the wound needs to be treated in time, the wound is subjected to bleeding and infection and suppuration due to improper treatment, and the wound can be infected with tetanus in serious cases to endanger the life of the patient.
In the process of wound treatment, the first and most widely applied mode is to utilize a disinfection product to kill and remove pathogens, the main mechanism is to utilize physical or chemical action to destroy the pathogens to inactivate the pathogens, and the mode can reduce the probability of wound worsening infection, greatly relieve the pain of patients and improve the survival rate of patients with serious wounds. However, these products are single-function and only have a bactericidal and disinfectant effect, and wounds with lost skin barrier are still at risk of infection before they are not completely healed.
The difficulty and significance for solving the technical problems are as follows:
therefore, based on the problems, the antibacterial agent provided by the invention can kill various pathogenic microorganisms and inhibit bacteria for a long time; meanwhile, the film has the functions of film formation and moisture preservation, the formation of the film can effectively prevent microorganisms from entering, the moist environment of the wound surface can be maintained, and the wound nursing disinfection product for accelerating the wound healing has important practical significance.
Disclosure of Invention
The invention aims to provide a novel antibacterial bactericide which can kill various pathogenic microorganisms and inhibit bacteria for a long time for solving the technical problems in the prior art; meanwhile, the wound care disinfectant has the functions of film formation and moisture preservation, can effectively prevent microorganisms from entering the wound, can maintain the moist environment of the wound surface, and can accelerate the healing of the wound.
The technical scheme adopted by the invention for solving the technical problems in the prior art is as follows:
a wound care disinfection product comprises a cationic bactericide, a high-molecular film-forming material and purified water, wherein the mass concentration range of the cationic bactericide is 0.005-5%, the mass concentration range of the high-molecular film-forming material is 0.01-25%, and the balance of the purified water.
The invention discloses a wound nursing disinfection product. The product is prepared by dissolving and blending cationic bactericide serving as an effective antibacterial component and high polymer material with good biocompatibility serving as a film forming substance in different proportions. The film-forming moisturizing disinfection product contains a cationic bactericide, can kill various bacteria, fungi, viruses, spores and the like, and can inhibit bacteria for a long time; the film-forming moisturizing disinfection product is suitable for various wound surfaces, contains high-molecular film-forming substances, can form a film on the surface of skin without dead angles, and can block bacteria; the high molecular material in the film-forming moisturizing disinfection product contains abundant hydrophilic groups, and can maintain a moist environment of a wound and accelerate the healing of the wound.
The wound nursing disinfection product has the functions of sterilization, film forming and moisture preservation. The antibacterial agent is prepared by dissolving and blending cationic bactericide serving as an effective antibacterial component and high polymer material with good biocompatibility serving as a film forming substance in different proportions. The obtained product is suitable for various wound surfaces, has the characteristics of sterilization, film formation and moisture retention, has the sterilization effect and can resist bacteria for a long time, and the formed film can block bacteria and maintain a moist healing environment.
The invention can also adopt the following technical scheme:
in the wound care disinfectant product, the cationic bactericide is one or more of chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine hydrochloride, benzalkonium bromide, benzalkonium chloride, benzethonium chloride, double-chain quaternary ammonium salt and polymer quaternary ammonium salt.
The cationic bactericide can be adsorbed and gathered on the cell wall of negatively charged microorganisms by virtue of self positive charges to generate a chamber resistance effect, so that the growth of bacteria is inhibited; meanwhile, hydrophobic alkyl on the cationic disinfectant molecule can also react with a hydrophilic group of the microorganism to change the permeability of the cell membrane of the microorganism, so that the lysis effect is generated, the structure of the microorganism is damaged, and the dissolution and death of the microorganism are caused.
In the wound care disinfectant product, the polymer film-forming material is one or more of polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone, gelatin, collagen, xanthan gum, sodium alginate, chitosan and chitosan derivatives, carboxymethyl cellulose and carboxymethyl cellulose derivatives, hydroxypropyl methyl cellulose, hydroxybutyl methyl cellulose, ethyl methyl cellulose, carboxymethyl methyl cellulose, hydroxymethyl ethyl cellulose, hydroxypropyl cellulose and hydroxyethyl cellulose.
In conclusion, the invention has the following advantages and positive effects:
1. the wound care disinfection product provided by the invention has the effects of sterilization, film formation and wound surface protection.
2. According to the wound care disinfection product provided by the invention, the cationic bactericide and the high-molecular film-forming material are blended to form an antibacterial protective film, and the protective film can kill residual bacteria on the skin, can kill external microorganisms and effectively block the invasion of the microorganisms.
3. The antibacterial protective film formed by the wound care disinfection product provided by the invention has a long-acting antibacterial effect.
4. According to the wound care disinfection product provided by the invention, the formed antibacterial protective film contains rich hydrophilic groups, so that the wound surface can be maintained in a moist environment while the wound is protected, and the wound healing is accelerated.
Drawings
FIG. 1 is a photograph comparing the results of the field test of disinfection of the skin by the disinfectant in example one;
FIG. 2 is a photograph showing the comparison of the effects of the simulation test of persistent bacteriostatic effect in the first example;
FIG. 3 is a photograph comparing the effect of the test for the effect of inhibiting the invasion of bacteria in the first embodiment;
FIG. 4 is a photograph of the sterilized product of example two after film formation.
Detailed Description
Example 1:
1) a wound care disinfecting product consisting of: 0.8g of polyhexamethylene biguanide hydrochloride, 20mL of polyethylene glycol 40020mL of water 80mL of the composition.
2) A wound care disinfection product is implemented according to the following steps:
the method comprises the following steps: dissolving 0.8g of polyhexamethylene biguanide hydrochloride in 80mL of water, and stirring until the solution is clear and transparent to obtain a solution A;
step two: dissolving 20mL of polyethylene glycol 400 in the solution A, stirring to homogenize, and filling to obtain the wound care disinfection product.
The effect is as follows:
1. disinfectant on-site test for skin disinfection
The samples obtained in example 1 were subjected to field experiments according to the sterilization specifications. Before disinfection, the subject was allowed to rub the inner middle sections of the left and right forearms against each other sufficiently, the template was placed on the surface of the inner middle section of the left forearm of the subject, soaked in a test tube containing 10ml of diluent with a sterile cotton swab, squeezed on the tube wall and sampled. After sampling, the sampling end of the cotton swab is cut into the sampling liquid test tube in a sterile operation mode, and the vibration is performed for 200 times. After the wound care disinfectant is uniformly sprayed on a test area, the action is carried out for 2min, a neutralizer is used for replacing a diluent, and natural bacteria remained on the inner side surface of the right front arm of a subject are sampled once in the same method as a positive control group to be used as a test group sample. Taking 1.0ml of samples of the test group and the positive control group respectively, inoculating 2 plates to each sample by a pouring method, placing the samples in a 37 ℃ incubator for culturing for 48h, and observing the final result as shown in the attached figure 1 of the specification. The experiment shows that in practical application, the wound care disinfectant has a good sterilization effect. In the specification, in the attached figure 1, (A) is a positive control group; (B) are test groups.
2. Simulation test of lasting bacteriostatic effect
The sample obtained in example 1 was subjected to a simulation experiment for a lasting bacteriostatic effect. Before disinfection, 10 pieces of silica gel were rubbed thoroughly against the simulated skin. 2 simulated skins were taken, soaked in a 10mL dilution tube with a sterile cotton swab in the specified test area, squeezed dry on the tube wall and sampled. After sampling, the sampling end of the cotton swab is cut into a sampling liquid test tube in an aseptic operation mode, and the sampling end is rapped 200 times to be positive. Sucking 1mL of sample liquid, placing the sample liquid in a plate, inoculating by a pouring method, placing the plate in a 37 ℃ incubator for culturing for 48 hours, and observing the growth number of bacterial colonies.
And (3) disinfecting the remaining 8 simulated skins by using the wound care disinfectant, and placing the simulated skins in a room-temperature common environment without any protection treatment in the experimental interval period. The operation was carried out by the same method with neutralizing agent instead of diluent at 2min, 6h, 24h, and 48h, respectively, as test groups, and the number of colonies was observed, as shown in FIG. 2 of the specification. In the attached figure 2 of the specification, (A) - (E) respectively represent the growth conditions of bacterial colonies after the positive group, the disinfection for 2min, the disinfection for 6h, the disinfection for 24h and the disinfection for 48 h.
Log kill means were calculated from the number of colonies as shown in table 1.
Using SPSS19.0 software for metering data
(95% confidence interval) indicates that the comparison between the two groups at different time points was statistically significant for differences P < 0.05 using the t-test. According to the statistical result, the difference between each time point after disinfection and before disinfection is judged to have statistical significance, and the colony count of each sampling is reduced compared with that before disinfection after 2min, 5h, 30h and 48h after disinfection, so that the wound care disinfectant has the long-acting bacteriostatic effect under the method.
TABLE 1 mean log kill values for wound care solutions at different sampling times
| Point in time | Mean killing log | P value | 95％CI |
| Sterilizing for 2min | 1.00 | 0.000 | 0.91-1.08 |
| After 6h of disinfection | 0.89 | 0.005 | 0.59-1.19 |
| After 24 hours of disinfection | 0.98 | 0.000 | 0.83-1.12 |
| Sterilizing for 48h | 1.13 | 0.000 | 1.01-1.25 |
3. Test for the Effect of preventing invasion of bacteria
This experiment drops the microorganism onto a filter paper containing the sample of example 1. After the droplets are dried, a test is performed to determine if any viable microorganisms have penetrated to the other side of the test sample.
Taking a 50mm square sterile filter paper, and dropwise adding the filter paper with the concentration of 10 at the upper part75 drops of cfu/mL staphylococcus aureus liquid, wherein each drop is 0.1 mL. After drying at 22 ℃ for 6h in a sterile environment, the sample is placed on the surface of a blood agar plate with the inoculation surface facing upwards, the test sample is removed after contacting for 5s-6s, the plate is placed at 37 ℃ for culturing for 24h to serve as a positive control group, and a photograph is recorded. Taking a square of sterile filter paper of the same size, and placing on the filter paperAfter the wound care disinfectant is uniformly sprayed, the wound care disinfectant is dried at 22 ℃ for 16 hours, and the wound care disinfectant is dripped to be used as a test group by the same method, and the test group is recorded and photographed. A square sterile filter paper with the same size is taken, is not subjected to any treatment, is directly contacted with a blood agar plate for 5s-6s, is removed as a negative control, and is cultured for 24h and then is recorded and photographed.
As shown in the attached figure 3 of the specification, after the wound care disinfectant is sprayed, the bacterial liquid is added dropwise for experiment, no colony growth is observed in blood agar, and the colony growth is observed in the square area of the positive control group which is not sprayed with the wound care disinfectant, so that the antibacterial protective film layer can effectively block the bacterial invasion. The negative control is shown in the attached figure 3 (A); (B) is a test group; (C) is a positive control group. Among them, the white squares in group C resulted from colony growth.
Example 2:
1) a wound care disinfecting product consisting of: 5mL of chlorhexidine gluconate solution, 1g of polyvinylpyrrolidone and 100mL of water.
2) A wound care disinfection product is implemented according to the following steps:
the method comprises the following steps: dissolving 5mL of chlorhexidine gluconate solution in 100mL of water, and stirring until the solution is clear and transparent to obtain a solution A;
step two: and dissolving 1g of polyvinylpyrrolidone in the solution A, stirring to homogenize, and filling to obtain the wound care disinfection product.
The effect is as follows:
film formation experiment of sterilized product
Placing 10mL of the product in a glass plate with a diameter of 9mm, standing at 37 deg.C for 24h under simulated human body temperature, taking out, and cutting into 2 × 2.5 cm.
As shown in the specification and figure 4, under the simulated human body temperature, the product can form a transparent film which can be seen by naked eyes after the moisture is volatilized.
In conclusion, the invention can provide a novel antibacterial agent which can kill various pathogenic microorganisms and inhibit bacteria for a long time; meanwhile, the wound care disinfectant has the functions of film formation and moisture preservation, can effectively prevent microorganisms from entering the wound, can maintain the moist environment of the wound surface, and can accelerate the healing of the wound.
The present invention has been described in detail with reference to the above examples, but the description is only for the preferred examples of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (3)
1. A wound care disinfection product characterized by: the wound care disinfection product comprises a cationic bactericide, a high-molecular film-forming material and purified water, wherein the mass concentration range of the cationic bactericide is 0.005-5%, the mass concentration range of the high-molecular film-forming material is 0.01-25%, and the balance of the purified water.
2. The wound care disinfecting product of claim 1, wherein: the cationic bactericide is one or more of chlorhexidine gluconate, chlorhexidine acetate, polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine hydrochloride, benzalkonium bromide, benzalkonium chloride, benzethonium chloride, double-chain quaternary ammonium salt and polymer quaternary ammonium salt.
3. The wound care disinfecting product of claim 1, wherein: the high-molecular film-forming material is one or more of polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidone, gelatin, collagen, xanthan gum, sodium alginate, chitosan and chitosan derivatives, carboxymethyl cellulose and carboxymethyl cellulose derivatives, hydroxypropyl methyl cellulose, hydroxybutyl methyl cellulose, ethyl methyl cellulose, carboxymethyl methyl cellulose, hydroxymethyl ethyl cellulose, hydroxypropyl cellulose and hydroxyethyl cellulose.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010228913.4A CN111281880A (en) | 2020-03-27 | 2020-03-27 | Wound nursing disinfection product |
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| CN202010228913.4A CN111281880A (en) | 2020-03-27 | 2020-03-27 | Wound nursing disinfection product |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111771898A (en) * | 2020-07-08 | 2020-10-16 | 上海明涌新材料有限公司 | Safe and long-acting disinfection mother liquor |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
| CN117442524A (en) * | 2023-12-21 | 2024-01-26 | 深圳三林生物技术有限公司 | Infant wound disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN104399082A (en) * | 2014-12-09 | 2015-03-11 | 南阳市汇博生物技术有限公司 | Nutrient gel for sterilizing and healing wound surface and preparation method of nutrient gel |
| CN105284861A (en) * | 2015-10-30 | 2016-02-03 | 明光市良宇家俬有限公司 | Quick-acting disinfectant for sofa leather |
| US20170296670A1 (en) * | 2016-04-13 | 2017-10-19 | Sage Products, Llc | Chg-compatible composition and method |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN109125800A (en) * | 2018-09-15 | 2019-01-04 | 深圳市浓华生物电子科技有限公司 | A kind of preparation method for patch that moisture film cures the wound patch and moisture film is cured the wound |
-
2020
- 2020-03-27 CN CN202010228913.4A patent/CN111281880A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948520A (en) * | 2014-04-28 | 2014-07-30 | 辽宁科技大学 | Guanidyl composite disinfection and cleaning hand sanitizer and preparation method for same |
| CN104399082A (en) * | 2014-12-09 | 2015-03-11 | 南阳市汇博生物技术有限公司 | Nutrient gel for sterilizing and healing wound surface and preparation method of nutrient gel |
| CN105284861A (en) * | 2015-10-30 | 2016-02-03 | 明光市良宇家俬有限公司 | Quick-acting disinfectant for sofa leather |
| US20170296670A1 (en) * | 2016-04-13 | 2017-10-19 | Sage Products, Llc | Chg-compatible composition and method |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN109125800A (en) * | 2018-09-15 | 2019-01-04 | 深圳市浓华生物电子科技有限公司 | A kind of preparation method for patch that moisture film cures the wound patch and moisture film is cured the wound |
Non-Patent Citations (2)
| Title |
|---|
| 关志宇 主编: "《药物制剂辅料与包装材料》", 31 January 2017, 中国医药科技出版社 * |
| 周静宇 主编: "《血站消毒与感染管理》", 30 June 2018, 东南大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111771898A (en) * | 2020-07-08 | 2020-10-16 | 上海明涌新材料有限公司 | Safe and long-acting disinfection mother liquor |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
| CN117442524A (en) * | 2023-12-21 | 2024-01-26 | 深圳三林生物技术有限公司 | Infant wound disinfectant and preparation method thereof |
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Application publication date: 20200616 |