CN108186676A - A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof - Google Patents
A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof Download PDFInfo
- Publication number
- CN108186676A CN108186676A CN201810177756.1A CN201810177756A CN108186676A CN 108186676 A CN108186676 A CN 108186676A CN 201810177756 A CN201810177756 A CN 201810177756A CN 108186676 A CN108186676 A CN 108186676A
- Authority
- CN
- China
- Prior art keywords
- nano
- gel
- infection
- antibacterial gel
- nano material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a kind of infection of treat wound and the nano-antibacterial gels of promoting healing, and main component is Cu2WS4Nano material and gelling agent.No matter under the conditions of existing for shading or light, Cu2WS4Nano material is to gram-positive bacteria (staphylococcus aureus), Gram-negative bacteria (Escherichia coli) and the drug-fast bacteria (staphylococcus aureus of methicillin-resistant,) etc. MRSA excellent anti-microbial property is shown, more than 99.999% sterilizing rate can be realized under low concentration (0.1~5 μ g/mL).Cu2WS4Nano-antibacterial gel not only have good biological safety, but also at lower doses (0.01~1mg/kg) can effectively treat wound MRSA infect and have promotion wound healing ability.Nano-antibacterial gel provided by the present invention have manufacture craft is simple, have no toxic side effect, convenient drug administration, low dosage, high curative effect, low-cost characteristic, can effectively solve the problems, such as the bacterium infection of current biological medical field.
Description
Technical field
The invention belongs to nano-antibacterial technologies and traumatism treatment field, and in particular to a kind of treat wound infection and promoting healing
Nano-antibacterial gel.
Background technology
Bacterium is always the main reason for endangering publilc health, how to efficiently control and prevent the growth and sprawling of bacterium
An always deep concerned subject.Therefore, antibiotic preparation occupies a piece of wide market always in medical profession, most
Antibiotic preparation is by antibiotic or traditional Chinese medicine, and antibiotic is mainly used for treating various bacterium infections or pathogenic microorganisms sense
Class disease is contaminated, it is more notable in application initial performances, but for a long time and be widely applied with antibiotic, the drug resistance of bacterium becomes
It is more and more stronger, serious threat the health and safety of the mankind to microorganism infection, utilizes the antibiotic preparation of traditional Chinese medicine
Clinical effectiveness also unobvious.
It is worth noting that in the whole world, the annual medical expense for infectious disease is up to more than one hundred billion dollar, numerous systems
Medicine enterprise is ready to put among the research and development of new drug for a long time, however not only expense is extremely high for the research and development of a new and effective antibiotic preparation
High and time-consuming longer, the preparation produced may also only have extremely short service life because of the drug resistance of bacterium.Cause
And the antiseptic that excellent effect is developed by a kind of novel technology is increasingly paid close attention to by drugmaker.
With the development of nanometer technology and nano biological medicine, the mode of new long-term control microorganism infection disease is met the tendency of
And it gives birth to：Biological method is combined production nano-antibacterial new material, and combined with gel and preferably act on people with nanometer technology
Body.Nano material promotes the approach of inactivation of bacteria to be mainly：(1) nano particle is directly attached on bacterial membrane or direct object
Reason destroys bacterial membrane；(2) metal ion that nano particle releases destroys the protein or DNA in bacterium；(3) production of active oxygen
It is raw to destroy lipid and DNA.Here, nano material shows the characteristic not limited by bacterial drug resistance, it is often more important that activity
The generation of species, what can be more prone to penetrates into inside bacterium, destroys the DNA and protein of bacterium.In recent years, many nanometers
Material (such as silver-colored, graphene, titanium dioxide, Transition-metal dichalcogenide etc.) has been applied in antibacterial field；Gel is
A kind of to can absorb a large amount of solvents but macromolecule or macromolecular insoluble in solvent, they in water can rapid swelling equilibrium
And its shape and three-dimensional space network structure can be kept, also referred to as " soft material ".Gel shows the characteristic of many polymer,
It will not freely dissolve, such material can stay in original place in physiological conditions, while keep antimicrobial acivity.These characteristics
Them is made to be desirably applied to wound healing, implantation material, conduit coating, skin infection or even aperture barrier.
But there are following problems in the prior art：Metal nanoparticle is excessively used there are certain toxicity
It can be detained in the environment；The preparation process of antimicrobial nano material is more complicated cumbersome；Bacteriostasis rate is relatively low.
Invention content
In view of the above problems, present invention seek to address that deficiency of the prior art, provides a kind of treat wound sense
The nano-antibacterial gel of dye and promoting healing chooses Cu2WS4Nano material adds in corresponding gelling agent, is formed as antiseptic
Cu2WS4Nano-antibacterial gel plays the role of treat wound infection, promotes wound healing.
To achieve these goals, the technical solution adopted in the present invention is as follows：A kind of treat wound of the present invention
The nano-antibacterial gel of infection and promoting healing is by Cu2WS4The aqueous solution of nano material and the aqueous solution of gel are mixed with
, choose Cu2WS40.5-5 parts of the aqueous solution of nano material；0.5-5 parts of gelling agent aqueous solution is mixed, the Cu2WS4It receives
The volume ratio of the aqueous solution of rice material and the aqueous solution of gel is 1：0.5~5, the Cu2WS4The aqueous solution of nano material it is dense
It spends for 1~100 μ g/mL, the gelling agent aqueous solution mass percent is 0.1%~50%.
Further, the Cu2WS4Nano material can be one kind in nanometer sheet, nanocube, nano thin-film.
Further, the nanometer sheet grain size be 500~1000nm, nanocube size be 10~500nm, nanometer thin
Film diameter is 100~300nm.
Further, the gel is gelatin, peach gum, sodium alginate, agar, hydroxymethyl cellulose, polyvinyl pyrrole
It is one or more in alkanone, agarose.
Further, the preparation method of the nano-antibacterial gel of a kind of treat wound infection and promoting healing, which is characterized in that
Include the following steps：
Step 1：Prepare Cu2WS4The aqueous solution of nano material；
Step 2：Gel is dissolved in the water, high-temperature heating forms aqueous solution, treats that gel solution is cooled to 35~55 DEG C,
Add in Cu2WS4The aqueous solution of nano material is mixed to uniform；
Step 3：By above-mentioned Cu2WS4The gel solution of nano material is preserved at room temperature to get nano-antibacterial gel.
It has the beneficial effect that：
(1) present invention uses Cu2WS4Nano material is as antiseptic, with reference to natural gelling agent, without traditional Chinese medicine ingredients and
Antibiotic is led to the problem of because side effect and drug-fast bacteria may be not present.
(2) anti-microbial property of wide spectrum.Available in gram-positive bacteria, Gram-negative bacteria and drug-fast bacteria, and not by
The constraint of external environmental light.
(3) dosage of product is extremely low, greatly improves biological safety.
(4)Cu2WS4Nano-antibacterial gel is for the wound of living sample and the Wound healing and bone regeneration of drug-fast bacteria infection, in low dosage
Under show effective treatment and promote the ability of wound healing.
(5)Cu2WS4The preparation process of nano-antibacterial gel is simple.
(6) it is easier to smear and act on wound by the way of gel, greatly improves administration rate.
Description of the drawings
Fig. 1 a are that the embodiment of the present invention 1 verifies Cu2WS4The result schematic diagram of the haemolysis effect of nano material；
Fig. 1 b are that the embodiment of the present invention 1 verifies Cu2WS4The result schematic diagram of the biological safety of nano material；
Fig. 2 is that the embodiment of the present invention 2 verifies Cu2WS4The result schematic diagram of the in-vitro antibacterial performance of nano material；
Fig. 3 a are Cu of the present invention2WS4The photo of nano-antibacterial gel；
Fig. 3 b are that the embodiment of the present invention 3 verifies Cu2WS4The result schematic diagram of the in-vitro antibacterial performance of nano-antibacterial gel；
Fig. 4 is that the embodiment of the present invention 4 verifies Cu2WS4Signal of the nano-antibacterial gel for the Wound healing and bone regeneration effect of live body
Figure；
Wherein, Water：Water；Saline:Physiological saline；CWS:Cu2WS4Nano material；Heart：The heart；Liver：Liver；
Spleen：Spleen；Lung：Lung；kidney：Kidney；E.coli：Escherichia coli (Gram-negative bacteria)；S.aureus：Golden yellow grape
Coccus (gram-positive bacteria)；Light no treatment：Cu is not added under illumination2WS4Nano material processing；Dark CWS：It hides
Add Cu under light2WS4Nano material processing；Light CWS：Add Cu under illumination2WS4Nano material processing.
Specific embodiment
In order to which those of ordinary skill in the art is made to be better understood on technical scheme of the present invention, 1- below in conjunction with the accompanying drawings
4 and embodiment technical scheme of the present invention is further described, but protection scope of the present invention is not limited thereto.
Basic principle, the main features and advantages of the present invention have been shown and described above.But the foregoing is merely this hairs
Bright specific embodiment, technical characteristic of the invention are not limited thereto, and any those skilled in the art is not departing from this hair
The other embodiment obtained under bright technical solution should all cover among the scope of the claims of the present invention.
Embodiment 1
A) with reference to Fig. 1 a, the haemolysis effect of fresh people's blood research nano material is used.
First, 3-10mL physiological saline is added in the centrifuge tube equipped with new blood, after mixing, by centrifuge tube be placed in from
In scheming.At 4 DEG C, 500~3000rpm is centrifuged 5 minutes, and same centrifugal condition is cleaned 3 times using physiological saline.
Pure 0.1~1mL erythrocytes are then dissolved in mixing in 5~10mL physiological saline.In 1mL various concentrations
Cu2WS40.01~0.8mL erythrocytes are added in the normal saline solution (0.8~34 μ g/mL) of nano material, mixing is placed on
In miniature table.
It it is 37 DEG C in temperature, rotating speed is under 50~200rpm, is incubated 0.5~10h.
It can be seen that from FIG. 1 a that Cu2WS4Nano material has good biocompatibility.
B) with reference to Fig. 1 b, the verification of the biological safety of live body
BALA/c mouse (18-22g, female) are divided into 2 groups (every group 6), pass through 100 μ L physiology of tail vein injection respectively
Brine is as a control group；Inject 100 μ L Cu2WS42 groups of mouse are then positioned over by nano material aqueous dispersions as experimental group
In cage.
After the free activity of mouse 14 days, mouse is euthanized, main organ (heart, liver, spleen, lung, kidney) is removed and is placed in good fortune
It is fixed in your Malin, then slice, embedding, dyeing etc..
The variation of these organ-tissues is observed finally by Olympus inverted microscope；
The result shown from Fig. 1 b can be seen that by Cu2WS4The organ-tissue of nano material processing is compared with the control group
Without significant change, illustrate Cu2WS4Nano material is non-toxic.
Embodiment 2
With reference to Fig. 2, Escherichia coli (Gram-negative bacteria) and staphylococcus aureus (gram-positive bacteria) are deposited respectively
It is placed in 5~30% glycerine, is stored in -80 DEG C of refrigerators.
It using sterile pipette tips picking part frozen stock solution, scratches respectively on LB tablets, is placed in 37 DEG C of overnight incubations, form meat
The visible bacterium colony of eye.
Using pipette tips picking single bacterium colony in LB (peptone 10gL-1, yeast 5gL-1, sodium chloride 10gL-1) (1~
20mL) in culture solution, shake overnight (220rpm, 37 DEG C).
For the bacteria suspension for taking 1mL overnight in 1.5mL centrifuge tubes, 5000~12000rpm centrifuges 1~5min, adds in physiology salt
Water cleans twice.It is spare that final centrifugation product adds in the piping and druming resuspension of 1mL physiological saline.
200 μ L suspension are taken in 96 orifice plates, microplate reader measures OD value (OD 600nm), to determine the dense of bacterium
Degree.
Isometric bacteria suspension and Cu are taken respectively2WS4Nano material aqueous solution is in centrifuge tube, and in triplicate, control uses
Deionized water substitutes Cu2WS4Nano material.
220rpm shakes 0.5~12h in 37 DEG C of shaking tables.
Cu is assessed using coated plate counting method2WS4The anti-microbial property of nano material.
The result shown from Fig. 2 can be seen that compared with the control group, either in shading either under illumination condition,
The culture for being inoculated with Escherichia coli (Gram-negative bacteria) and staphylococcus aureus (gram-positive bacteria) handled by CWS
The increment of bacterial strain is all few on ware plate, illustrates that CWS has broad spectrum antibacterial performance, and is not constrained by external environmental light.
Embodiment 3
With reference to Fig. 3 a and 3b, mass percent is prepared first as 0.1%~50% gelling agent aqueous solution, it is high at 121 DEG C
Pressure sterilizing 20 minutes.
Then isometric gelling agent aqueous solution (35~55 DEG C) and physiological saline (saline) or Cu are measured respectively2WS4
Nano material aqueous dispersions after placing a period of time at room temperature, gradually form gel, gel imaging result is such as in vial
Shown in Fig. 3 a.
Staphylococcus aureus is stored in glycerine, is stored in -80 DEG C of refrigerators.It is frozen using sterile pipette tips picking part
Liquid is scratched on LB agar plates, is placed in 37 DEG C of incubators, is stood overnight.Then trained using pipette tips picking single bacterium colony in containing LB
In the 50mL centrifuge tubes for supporting base, mixing is blown and beaten, centrifuge tube is positioned in 37 DEG C of shaking tables, concussion (200rpm) is overnight.
200 μ L bacteria suspensions are taken in 96 orifice plates, microplate reader measures OD value (OD 600nm), to determine bacterial concentration.
A series of dilution is carried out to the suspension of bacterium using physiological saline, finally obtains a concentration of 1 × 108CFU/mL
Bacteria suspension it is spare.
It takes 10~200 μ L bacteria suspensions uniform on LB solid agar plates, being scratched using glass coater, uses pipettor point
Not Jia Ru 2~50 μ L volumes physiological saline gel (control group, Saline) and 2~50 μ LCu2WS4(the treatment of nano-antibacterial gel
Group, CWS) on LB agar plates, in duplicate, be placed in 37 DEG C of baking ovens and be incubated for 24 hours, strain growth situation as shown in Figure 3b, by
It can be seen that compared with the control group, being inoculated with Cu in Fig. 3 b2WS4Occur around nano-antibacterial gel position apparent antibacterial
Circle, illustrates Cu2WS4Nano-antibacterial gel has the ability for inhibiting bacteria growth.
Embodiment 4
A) in order to study Cu2WS4For nano-antibacterial gel for the treatment of wound infection, wound model is based upon mouse
Back.
The hair at BALA/c mouse (18-22g) back is cleaned out, the wound of a 2~8mm of diameter is cut using surgical scissors
Mouthful, use the 1*10 of liquid-transfering gun 100 μ L volumes of instillation4~1*109CFU/mL bacteriums or drug-fast bacteria are on wound.
Mouse is divided into 2 groups (every group 6), every for 24 hours, takes 5~50 μ L physiological saline gels (right using liquid-transfering gun respectively
According to group) and 5~50 μ LCu2WS4Nano-antibacterial gel (treatment group) photographs to record wound healing situation on wound.
B) in order to study Cu2WS4For nano-antibacterial gel for the promotion of wound healing, wound model is based upon mouse
Back.
The hair at BALA/c mouse (18-22g) back is cleaned out, cuts 2~10mm's of diameter using surgical scissors
Wound.
Mouse is divided into 2 groups (every group 6), every for 24 hours, every for 24 hours, takes 5~50 μ L physiology salts using liquid-transfering gun respectively
Hydrogel (control group) and 5~50 μ L Cu2WS4Nano-antibacterial gel (treatment group) photographs to record wound and is cured on wound
Conjunction situation.
As can be seen from Figure 4 compared with the control group, by Cu2WS4Mouse back after the treatment of nano-antibacterial Gel Treatment
Wound healing effect is more preferable, illustrates Cu2WS4Nano-antibacterial gel has the wound for the treatment of drug-fast bacteria infection and promotes wound healing
Ability.
Claims (6)
1. a kind of treat wound infection and the nano-antibacterial gel of promoting healing, which is characterized in that its concrete component is as follows：Cu2WS4
0.5-5 parts of the aqueous solution of nano material；
0.5-5 parts of gelling agent aqueous solution.
2. the nano-antibacterial gel of a kind of infection of treat wound and promoting healing according to claims 1, which is characterized in that
The Cu2WS4A concentration of 1~100 μ g/mL of the aqueous solution of nano material, the gelling agent aqueous solution mass percent are
0.1%~50%.
3. the nano-antibacterial gel of a kind of infection of treat wound and promoting healing according to claims 1, which is characterized in that
The Cu2WS4Nano material is nanometer sheet, one kind in nanocube, nano thin-film form.
4. the nano-antibacterial gel of a kind of infection of treat wound and promoting healing according to claims 1, which is characterized in that
The gelling agent is gelatin, in peach gum, sodium alginate, agar, hydroxymethyl cellulose, polyvinylpyrrolidone, agarose
It is one or more.
5. the nano-antibacterial gel of a kind of infection of treat wound and promoting healing according to claims 3, which is characterized in that
The nanometer sheet grain size is 500~1000nm, and nanocube size is 10~500nm, and nano thin-film diameter is 100
~300nm.
6. the nano-antibacterial gel of a kind of infection of treat wound and promoting healing according to any one of claims 1-4
Preparation method, which is characterized in that include the following steps：
Step 1：Prepare Cu2WS4The aqueous solution of nano material；
Step 2：Gel is dissolved in the water, high-temperature heating forms aqueous solution, treats that gel solution is cooled to 35~55 DEG C, adds in
Cu2WS4The aqueous solution of nano material is mixed to uniform；
Step 3：By above-mentioned Cu2WS4The gel solution of nano material is preserved at room temperature to get nano-antibacterial gel.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810177756.1A CN108186676A (en) | 2018-03-05 | 2018-03-05 | A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof |
| PCT/CN2018/111545 WO2019169873A1 (en) | 2018-03-05 | 2018-10-24 | Nano antibacterial gel for treating wound infection and promoting healing and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810177756.1A CN108186676A (en) | 2018-03-05 | 2018-03-05 | A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108186676A true CN108186676A (en) | 2018-06-22 |
Family
ID=62595029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810177756.1A Pending CN108186676A (en) | 2018-03-05 | 2018-03-05 | A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108186676A (en) |
| WO (1) | WO2019169873A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019169873A1 (en) * | 2018-03-05 | 2019-09-12 | 南京邮电大学 | Nano antibacterial gel for treating wound infection and promoting healing and preparation method therefor |
| CN110974961A (en) * | 2019-12-19 | 2020-04-10 | 南京邮电大学 | Nano composite material for removing bacterial biofilm by enhancing photo-thermal based on enzymatic degradation and preparation method and application thereof |
| CN111012798A (en) * | 2020-01-15 | 2020-04-17 | 南京邮电大学 | Nano antibacterial agent capable of quickly and efficiently killing drug-resistant bacteria and preparation method thereof |
| CN111286971A (en) * | 2020-02-17 | 2020-06-16 | 北京赛夫依特生物科技有限公司 | Photocatalyst nano fabric finishing liquid and preparation method and application thereof |
| CN113599506A (en) * | 2021-05-31 | 2021-11-05 | 长沙理工大学 | Platinum nanoenzyme/glucose oxidase @ hyaluronic acid composite antibacterial material and preparation and application thereof |
| WO2023070886A1 (en) * | 2021-10-25 | 2023-05-04 | 中国科学院深圳先进技术研究院 | Cu2ws4 nanoparticle resistant to bacterial biofilm infection and use of photocatalytic properties thereof in bacterial biofilm infection |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116999386B (en) * | 2023-08-14 | 2024-04-09 | 陕西科技大学 | Copper-containing hydrogel and application thereof in inhibiting bacterial infection |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106346018A (en) * | 2016-09-21 | 2017-01-25 | 武汉工程大学 | Preparation method and application of agarose/nano-silver composite gel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186676A (en) * | 2018-03-05 | 2018-06-22 | 南京邮电大学 | A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof |
-
2018
- 2018-03-05 CN CN201810177756.1A patent/CN108186676A/en active Pending
- 2018-10-24 WO PCT/CN2018/111545 patent/WO2019169873A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106346018A (en) * | 2016-09-21 | 2017-01-25 | 武汉工程大学 | Preparation method and application of agarose/nano-silver composite gel |
Non-Patent Citations (1)
| Title |
|---|
| SELVARAJ KANNAN等: "Antibacterial studies of novel Cu2WS4 ternary chalcogenide synthesized by hydrothermal process", 《JOURNAL OF SOLID STATE CHEMISTRY》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019169873A1 (en) * | 2018-03-05 | 2019-09-12 | 南京邮电大学 | Nano antibacterial gel for treating wound infection and promoting healing and preparation method therefor |
| CN110974961A (en) * | 2019-12-19 | 2020-04-10 | 南京邮电大学 | Nano composite material for removing bacterial biofilm by enhancing photo-thermal based on enzymatic degradation and preparation method and application thereof |
| CN110974961B (en) * | 2019-12-19 | 2022-02-08 | 南京邮电大学 | Nano composite material for removing bacterial biofilm by enhancing photo-thermal based on enzymatic degradation and preparation method and application thereof |
| CN111012798A (en) * | 2020-01-15 | 2020-04-17 | 南京邮电大学 | Nano antibacterial agent capable of quickly and efficiently killing drug-resistant bacteria and preparation method thereof |
| CN111012798B (en) * | 2020-01-15 | 2022-03-18 | 南京邮电大学 | Nano antibacterial agent for killing drug-resistant bacteria and preparation method thereof |
| CN111286971A (en) * | 2020-02-17 | 2020-06-16 | 北京赛夫依特生物科技有限公司 | Photocatalyst nano fabric finishing liquid and preparation method and application thereof |
| CN113599506A (en) * | 2021-05-31 | 2021-11-05 | 长沙理工大学 | Platinum nanoenzyme/glucose oxidase @ hyaluronic acid composite antibacterial material and preparation and application thereof |
| WO2023070886A1 (en) * | 2021-10-25 | 2023-05-04 | 中国科学院深圳先进技术研究院 | Cu2ws4 nanoparticle resistant to bacterial biofilm infection and use of photocatalytic properties thereof in bacterial biofilm infection |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019169873A1 (en) | 2019-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108186676A (en) | A kind of nano-antibacterial gel of treat wound infection and promoting healing and preparation method thereof | |
| CN103191461B (en) | A kind of containing hyaluronic wound care dressing | |
| CN104857551B (en) | A kind of silver-containing antibacterial dressing and preparation method | |
| CN104740690B (en) | A kind of marine organisms medicament-carried nano antibacterial super slippery coating | |
| Paladini et al. | Effect of silver nanocoatings on catheters for haemodialysis in terms of cell viability, proliferation, morphology and antibacterial activity | |
| CN106344954A (en) | Bio-antimicrobial bacterial cellulose dressing and preparation method thereof | |
| Das et al. | Microbial biofilms: pathogenicity and treatment strategies | |
| CN114392388A (en) | Hydrogel composition and application thereof | |
| CN111281880A (en) | Wound nursing disinfection product | |
| CN108744014A (en) | A kind of preparation method and products thereof with slow releasing function antiseptic dressing | |
| CN107325319B (en) | Preparation method and application of porous polyvinylidene fluoride composite nano-silver film | |
| Sathish et al. | Biomedical applications of carrageenan hydrogel impregnated with zinc oxide nanoparticles | |
| CN111714455A (en) | Quaternary ammonium salinization chitin anti-pathogenic microorganism spray, preparation method and application thereof | |
| CN109593114B (en) | Limax antibacterial peptide, extraction method and application thereof | |
| Kaemmel et al. | On the function of biosynthesized cellulose as barrier against bacterial colonization of VAD drivelines | |
| CN115006546B (en) | Disulfide heterojunction material for promoting wound healing and preparation method thereof | |
| CN103951732A (en) | Antibacterial peptide | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN107233609B (en) | Ligustrum-lysozyme anti-infection dressing and preparation method and application thereof | |
| Zvezdova | Applications of chitosan-sulfathiazole as antimicrobial agent | |
| CN116999386B (en) | Copper-containing hydrogel and application thereof in inhibiting bacterial infection | |
| CN109644988A (en) | A kind of machine perfusion system mitigating organ transplant postoperative infection | |
| WO2018066580A1 (en) | Wound healing agent having activity to promote antibacterial properties and wound healing properties | |
| CN114949338B (en) | Hydrogel capable of resisting drug-resistant bacteria for long time and preparation method and application thereof | |
| CN115252884B (en) | Powder composition and application thereof in preparation of pet wound powder dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180622 |