CN105079858B - Liquid dressing and its preparation method are repaired in a kind of wound sterilization - Google Patents
Liquid dressing and its preparation method are repaired in a kind of wound sterilization Download PDFInfo
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- CN105079858B CN105079858B CN201510484327.5A CN201510484327A CN105079858B CN 105079858 B CN105079858 B CN 105079858B CN 201510484327 A CN201510484327 A CN 201510484327A CN 105079858 B CN105079858 B CN 105079858B
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Abstract
It is sterilized the invention discloses a kind of wound and repairs liquid dressing and its preparation method, it is using water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer as main active that liquid dressing is repaired in the wound sterilization, has the double emulsification system solution for sterilizing repair function using macromolecule emulsifier by what emulsifier was formed.It can promote wound healing and ooze out, moreover it is possible to which antibacterial anti-infection is applicable in the flushing of the related surface of a wound such as burn and scald, knife wound and chronic infection surface of a wound or soak treatment.Liquid dressing preparation method is repaired in wound sterilization of the invention includes the preparation of water soluble amino polysaccharide emulsified solution, the preparation of antibiotic complex emulsified solution, double emulsified solution systems compounding, four steps of sterilizing.
Description
Technical field
The present invention relates to medical drugs, furthermore, it is understood that being related to a kind of wound sterilization repairs liquid dressing and its preparation method.
Technical background
Low molecular chitosan, chitosan hydrochloride, chitosan quaternary ammonium salt, carboxyl chitosan, carboxymethyl chitosan, hydroxypropyl
The water soluble aminos polysaccharide such as chitosan is the good biomaterial of histocompatbility, can promote the formation of granulation and tissue, have
It is anti-inflammatory it is impervious go out effect, the flushing or soak of animal large area open wound can be used for.Carboxyl chitosan or carboxylic first therein
Base enclosure glycan is the soluble derivative of chitosan, is to gather aminocarboxylated polysaccharide and polyampholyte.Itself is nontoxic,
It is nonirritant, without challeng.In water soluble amino polysaccharide have a large amount of free amino groups and carboxyl, therefore itself have compared with
Weak natural bacteriostatic activity, enhancing its antibiotic property will be so that it be more widely applied, but due to the amphoteric polymer of its own
Characteristic can flocculate in the solution with many polyanionic compounds or polycationic compounds so that by and other
The mode of substance compounding improves the difficult of carboxyl chitosan solution antibiotic property.
Glutaraldehyde, benzoic acid, Phenoxyethanol, isopropanol, benzylalcohol, methaform, 2,4 chlorobenzyl alcohols, 2- phenoxetols etc. disappear
Malicious preservative has Pseudomonas aeruginosa stronger killing effect, weaker to other gramnegative bacteriums and positive bacteria effect.It can
For treating the surface injury of charrin's disease, burn and purulence ulcer.It is typically used as the preservative of cosmetics, vaccine and drug.
Phenoxyethanol is a kind of colourless oily liquids formed by ethylene glycol and menthylphenoxypolyethoxy ethanol, belongs to a kind of alcohols disinfection preservative.
But disinfection preservative and other substances are not compounded to provide in the prior art the technology of more effect liquid.
The high Molecularly Imprinted Polymer sterilization such as polyhexamethylene guanide, poly hexamethylene biguanide, octyl trichlamide, polylysine and its esters
Disinfectant is wide spectrum disinfective agent, has the excellent characteristics such as low effective concentration, work fast, property stabilization.
Poly hexamethylene biguanide, that is, PHMB therein has excellent performance soluble easily in water, can use at normal temperatures.It can be long
Phase is not antibacterial and without side-effects, non-corrosive, colourless, odorless, nontoxic, non-ignitable, quick-fried, safe to use, it may be said that is a kind of optimal
Environment-friendly type macromolecule polymer disinfection sanitizer.Its sterilization mechanism is：Ionization can be generated in aqueous solution, its hydrophilic base portion
Position usually in electronegative all kinds of bacteriums, cell entry cell membrane, inhibits film lactones plastid and closes containing strong electropositive, absorption
Into causing thalline apoptosis.
The substance is widely used in industrial, agriculture, various aspects in medical and daily life antibacterial or sterilization.But
High molecular polymer disinfection sanitizer and other substances are not compounded to provide in the prior art the technology of more effect liquid.
The macromolecule latexes such as polyisobutylene succinic acid sorbitol ester, poloxamer, polyvinylpyrrolidone, alkyl glycosides APG
Agent has excellent physiological inertia, is not involved in human metabolism, has excellent biocompatibility, to skin, mucous membrane, eye etc.
Any stimulation is not formed；Also have the effects that detoxify, stop blooding, improve concentration of ordinary dissolution, prevent peritoneal adhesion, promote erythrocyte sedimentation rate.It is curing
Medicine, food, cosmetics are applied extensively in these fields closely related with health of people.
Polyvinylpyrrolidone, that is, PVP in macromolecule emulsifier, is a kind of non-ionic macromolecule compound, is N- second
Eneamide Type of Collective object.PVP or poloxamer are a kind of macromolecules as a kind of synthesizing water-solubility high-molecular compound
Surfactant can be used as dispersant, emulsifier, thickener, levelling agent, particle size modifier, have colloid protective effect, film forming
Property, caking property, hygroscopicity, solubilising or cohesion.But macromolecule emulsifier and other substances are not answered in the prior art
It is equipped with the technology that more effect liquid are provided.
It to sum up, in the prior art can be by water soluble amino polysaccharide, disinfection preservative, high molecular polymer sterilizing
Agent, macromolecule emulsifier and purifying water substance are compounded to provide a kind of mixing for being provided simultaneously with above-mentioned substance properties
The technical solution of object.
Wound particularly burn and scald is a kind of traumatic disease caused injury by extraneous factors such as fire, water, electricity, burn or boiling hot
The degree of wound is different, and the weight caused injury differs.Light damage skin, the muscle injury of weight, then heavy damage muscles and bones, no matter weight
Burn and scald, be required for carry out active treatment processing.
The drug of treat wound particularly burn and scald at present, mainly externally applied drug.There are paste, liquid, powder shape etc..Most
Good is liquid, is mainly characterized by medicine-feeding dressing no pain.In these Common drugs, common medical mechanism is prevention
Infection, wound healing are accelerated into scab and the promoting blood circulation and removing blood stasis, modes such as sorptivety control is wet.Common drug such as moist exposed burn cream,
Jingwanhong soft plaster ointment for scald, Glycyrrhiza Oil Compound, Kangfuxin Liquid etc..
However, the prior art fails to provide can have effects that burn and scald is promoted to heal and ooze out, moreover it is possible to antibacterial anti-
More effect drugs of infection.
The content of the invention
The present invention, which provides one kind, can promote wound healing and ooze out, moreover it is possible to antibacterial aseptic more effect wounds
Liquid dressing and preparation method thereof is repaired in sterilization.
In order to achieve the above objectives, the technical proposal of the invention is realized in this way：
It is sterilized the invention discloses a kind of wound and repairs liquid dressing, it is with water soluble amino polysaccharide, disinfection preservative
And high molecular polymer disinfection sanitizer be main active, using macromolecule emulsifier by emulsifier formed have kill
Double emulsification system solution of bacterium repair function, quality formula are as follows：
Optionally, the water soluble amino polysaccharide is carboxyl chitosan or carboxymethyl chitosan；
Optionally, the disinfection preservative is alcohols disinfection preservative；
Optionally, the high molecular polymer disinfection sanitizer is guanidine disinfection sanitizer；
Optionally, the macromolecule emulsifier is non-ionic macromolecule emulsifier；
Optionally, the alcohols disinfection preservative is Phenoxyethanol or isopropanol；
Optionally, the guanidine disinfection sanitizer is poly hexamethylene biguanide or polyhexamethylene guanide；
Optionally, the non-ionic macromolecule emulsifier is polyvinylpyrrolidone or poloxamer；
Optionally, the quality that liquid dressing is repaired in the wound sterilization is formulated as follows：
Optionally, the quality that liquid dressing is repaired in the wound sterilization is formulated as follows：
It is sterilized the invention also discloses a kind of wound and repairs liquid dressing preparation method, this method includes：
(1) water soluble amino polysaccharide is added in purified water, under 50 DEG C~100 DEG C water bath conditions, water is made by stirring
Dissolubility glycosaminoglycan is completely dissolved in purified water, then, under 50 DEG C~100 DEG C water bath conditions and the stirring of liquid is kept to exist
50 revs/min or more, macromolecule emulsifier is added in into liquid, continues to stir, makes emulsified solution mixing abundant, obtains homogeneous
Water soluble amino polysaccharide emulsified solution, it is spare；
(2) first high molecular polymer disinfection sanitizer is put into purified water, under 50 DEG C~100 DEG C water bath conditions, passed through
Stirring high molecular polymer disinfection sanitizer is made to be completely dissolved in purified water, then under 50 DEG C~100 DEG C water bath conditions and
The stirring of liquid is kept to add in macromolecule emulsifier at 50 revs/min or more, continue to stir, makes emulsified solution mixing abundant, it
Afterwards under 50 DEG C~100 DEG C water bath conditions, the disinfection preservative of addition is uniformly mixed and can obtain homogeneous antibiotic complex breast
Change solution, it is spare；
(3) under 50 DEG C~100 DEG C water bath conditions, water soluble amino polysaccharide emulsified solution and antibiotic complex emulsification are kept
Any one solution in solution answers water soluble amino polysaccharide emulsified solution and antibacterial under 50 revs/min or more of stirring
Another solution closed in object emulsified solution is added thereto with being no more than the speed of 20 ml/mins, is uniformly mixed, and is obtained double
Emulsification system solution；
(4) by after double emulsification system solution are dispensed obtained by step (3), the item in 115 DEG C of temperature or more and F0 value >=8
Moist heat sterilization is carried out under part and sterilizes reparation liquid dressing up to wound.
By above-mentioned as it can be seen that of the invention this with the sterilization of water soluble amino polysaccharide, disinfection preservative and high molecular polymer
Disinfectant is main active, the double emulsified bodies with sterilization repair function being made of using macromolecule emulsifier emulsifier
It is the flushing and soak that solution can be used in empyrosis wound surface, is that one kind can promote wound healing and ooze out, moreover it is possible to press down
Liquid dressing is repaired in the aseptic more effect wound sterilizations of bacterium.The present invention include water soluble amino polysaccharide emulsified solution prepare,
Antibiotic complex emulsified solution is prepared, double emulsified solution systems compounding, the preparation method of four steps of sterilizing are capable of providing the wound and kill
Bacterium repairs liquid dressing.
Specific embodiment
The present invention core concept be：Technology using the present invention passes through water soluble amino polysaccharide emulsified solution
Preparation, four steps of the preparation of antibiotic complex emulsified solution, the compounding of double emulsified solution systems and sterilizing, will originally be difficult to same
The water soluble amino polysaccharide that is coexisted in system, disinfection preservative, high molecular polymer disinfection sanitizer, macromolecule emulsifier and pure
Change water and be re-dubbed liquid dressing, liquid dressing of the invention can retain the original characteristic of component so that liquid of the invention
Dressing have can promote wound healing and ooze out, moreover it is possible to antibacterial aseptic multi-efficiency.
In the present invention, the water soluble amino polysaccharide that similar nature can be substituted for each other includes low molecular chitosan, chitosan
Hydrochloride, chitosan quaternary ammonium salt, carboxyl chitosan, carboxymethyl chitosan, hydroxypropyl chitosan etc..
In the present invention, the disinfection preservative that similar nature can be substituted for each other include glutaraldehyde, benzoic acid, Phenoxyethanol,
Isopropanol, benzylalcohol, methaform, 2,4 chlorobenzyl alcohols, 2- phenoxetols etc..
In the present invention, the high molecular polymer disinfection sanitizer that similar nature can be substituted for each other includes polyhexamethylene
Guanidine, poly hexamethylene biguanide, octyl trichlamide, polylysine and its esters etc..
In the present invention, the macromolecule emulsifier that similar nature can be substituted for each other includes polyisobutylene succinic acid sorbierite
Ester, poloxamer, polyvinylpyrrolidone, alkyl glycosides APG etc..
To make the object, technical solutions and advantages of the present invention clearer, the present invention will be implemented by embodiment below
Mode is described in further detail.
The drug of embodiment 1-3 is prepared according to the formula of table one by following technique：
Under 80 DEG C of water bath conditions, after carboxyl chitosan is dissolved completely in purified water, liquid is kept in 80 DEG C of water-baths
Under the conditions of and maintain under 50 revs/min or more of stirring, add in polyvinylpyrrolidone, continue stirring 10~60 minutes, make
Emulsified solution mixing is abundant, obtains carboxyl chitosan emulsified solution, spare.
Under 80 DEG C of water bath conditions, poly hexamethylene biguanide is put into after being dissolved in purified water, keeps liquid in 80 DEG C of water
It under the conditions of bath and maintains under 50 revs/min or more of stirring, adds in polyvinylpyrrolidone, continue stirring 10~60 minutes,
Make emulsified solution mixing abundant, then in 80 DEG C of water bath conditions and under maintaining 50 revs/min or more of stirring, to emulsified solution
Middle addition Phenoxyethanol is uniformly mixed, obtains homogeneous antibiotic complex emulsified solution, spare.
Under 80 DEG C of water bath conditions, carboxyl chitosan emulsified solution is kept under 50 revs/min or more of stirring, it will be above-mentioned
Antibiotic complex emulsified solution is added in carboxyl chitosan emulsified solution with the speed of 10 ml/mins and (can also kept anti-
Bacterium compound emulsified solution is under 50 revs/min or more of stirring, by carboxyl chitosan emulsified solution with the speed of 10 ml/mins
Degree is added in antibiotic complex emulsified solution), sealed packaging can be carried out by being uniformly mixed.After sealed packaging by 115 DEG C with
On, after the moist heat sterilization of F0 value >=8 liquid dressing is repaired up to the wound sterilization of the present invention.
In 1-3 of the embodiment of the present invention, carboxyl chitosan is that one kind has bioactivity and range of viscosities is in 10mpas
Water soluble amino polysaccharide between~80mpas, can promote burn soup hinder wound healing, have it is anti-inflammatory it is impervious go out effect, in liquid
Played in dressing wound surface reparation, it is impervious go out function.
In 1-3 of the embodiment of the present invention, poly hexamethylene biguanide is applied with Phenoxyethanol by compounding offer fluid present invention
The sterilizing function of material.Staphylococcus aureus in the gram-positive cocci common to empyrosis wound surface, Gram-negative bacteria
In pseudomonas aeruginosa and candida albicans, the fungistatic effect of surface of a wound Aspergillus it is preferable.Suitable for burn and scald, knife wound and
Flushing or soak treatment in terms of the correlation surface of a wound such as chronic infection surface of a wound.
In 1-3 of the embodiment of the present invention, macromolecule emulsifier polyvinylpyrrolidone be both in the solution emulsifier and
It plays removing toxic substances, hemostasis, promote the effects that erythrocyte sedimentation rate.
[table one]
The formula of 1-3 of the embodiment of the present invention
Liquid dressing is repaired into prepared wound sterilization in embodiment 1-3, is 0.05% with mass percent concentration
Phenoxyethanol aqueous solution, the poly hexamethylene biguanide aqueous solution that mass percent concentration is 0.02% carry out bactericidal effect together
Contrast test, the strain of selection is staphylococcus aureus, pseudomonas aeruginosa, candida albicans, this 4 kinds of surface of a wound Aspergillus,
Bacterium colony concentration is diluted to 1 × 104CFU/ml dips this 4 kinds of bacterium solutions with sterilized cotton swabs, is dipped into embodiment 1-3 and matches somebody with somebody respectively
The Phenoxyethanol aqueous solution and quality percentage of liquid dressing, mass percent concentration for 0.05% are repaired in the wound sterilization made
Specific concentration is in 0.02% poly hexamethylene biguanide aqueous solution, and soaking time respectively sets 10min, 30min, 1h, then in beef
Cream peptone culture medium (staphylococcus aureus, pseudomonas aeruginosa) and potato agar culture medium (candida albicans, the surface of a wound
Aspergillus) on streak inoculation culture, each experiment is repeated 3 times.Observation whether there is colony growth after 7 days, and statistical result is shown in Table two.
Table two is the made liquid dressings of 1-3 of the embodiment of the present invention and 0.05% Phenoxyethanol aqueous solution and poly- the six of 0.02%
Methylene biguanides aqueous solution bactericidal effect contrast table, by the table, killing for liquid dressing is repaired in wound of the invention sterilization
Poly- six Asia that bacterium effect specific mass percent concentration is 0.05% Phenoxyethanol aqueous solution or mass percent concentration is 0.02%
The bactericidal effect of methyl biguanides aqueous solution will be got well.
Liquid dressing is repaired in the wound sterilization of the embodiment 1-3 prepared by special process of the present invention can realize each group
That divides is compatible, and maintains the original function of each component, and wound healing can be promoted and ooze out by being capable of providing one kind, also
It can antibacterial aseptic wound sterilization reparation liquid dressing.
Table two
The made liquid dressings of embodiment 1-3 and 0.05% Phenoxyethanol aqueous solution and 0.02% poly hexamethylene biguanide water
Solution bactericidal effect contrast table
The drug of 4-6 of the embodiment of the present invention is prepared according to the formula of table three by following technique：
Under 80 DEG C of water bath conditions, after carboxymethyl chitosan is dissolved completely in purified water by stirring, liquid is kept
Under 80 DEG C of water bath conditions and under 50 revs/min or more of stirring, poloxamer is added in, continues stirring 10~60 minutes, makes
Emulsified solution mixing is abundant, obtains carboxymethyl chitosan emulsified solution, spare.
Under 80 DEG C of water bath conditions, by stirring polyhexamethylene guanide is made to be dissolved in purified water after, then 50 DEG C~
Under 100 DEG C of water bath conditions and the stirring of liquid is kept to add in poloxamer under 50 revs/min or more of stirring, continue to stir
10~60 minutes, make emulsified solution mixing abundant, afterwards under 80 DEG C of water bath conditions, isopropanol is added in into emulsified solution, is mixed
It closes uniformly, obtains antibiotic complex emulsified solution, it is spare.
Under 80 DEG C of water bath conditions, carboxymethyl chitosan emulsified solution is kept under 50 revs/min or more of stirring, it will be upper
Stating antibiotic complex emulsified solution and being added to the speed of 10 ml/mins in carboxymethyl chitosan emulsified solution (can also protect
Antibiotic complex emulsified solution is held under 50 revs/min or more of stirring, by above-mentioned carboxymethyl chitosan emulsified solution with 10 millis
Liter/min speed be added in antibiotic complex emulsified solution), be uniformly mixed can carry out sealed packaging.After sealed packaging
By 115 DEG C or more, liquid dressing is repaired up to the wound sterilization of the present invention after the moist heat sterilization of F0 value >=8.
In 4-6 of the embodiment of the present invention, carboxymethyl chitosan is that one kind has bioactivity and range of viscosities is in 10mpa
Water soluble amino polysaccharide between s~80mpas, can promote burn soup hinder wound healing, have it is anti-inflammatory it is impervious go out effect, in liquid
Played in body dressing wound surface reparation, it is impervious go out function.
In 4-6 of the embodiment of the present invention, polyhexamethylene guanide provides fluid present invention dressing with isopropanol by compounding
Sterilizing function.Staphylococcus aureus in the gram-positive cocci common to empyrosis wound surface, in Gram-negative bacteria
Pseudomonas aeruginosa and candida albicans, the fungistatic effect of surface of a wound Aspergillus are preferable.Suitable for burn and scald, knife wound and chronic
Flushing or soak treatment in terms of the correlation surface of a wound such as infective wound surface.
In 4-6 of the embodiment of the present invention, macromolecule emulsifier poloxamer is both in the solution emulsifier and plays solution
Poison, hemostasis promote the effects that erythrocyte sedimentation rate.
[table three]
The formula of 4-6 of the embodiment of the present invention
Liquid dressing is repaired into prepared wound sterilization in above-described embodiment 4-6, is 0.2% with mass percent concentration
Isopropanol water solution and polyhexamethylene guanide aqueous solution that mass percent concentration is 1% carry out the comparison of bactericidal effect together
Experiment, the strain of selection is staphylococcus aureus, pseudomonas aeruginosa, candida albicans, this 4 kinds of surface of a wound Aspergillus, bacterium colony
Concentration is diluted to 1 × 104CFU/ml dips this 4 kinds of bacterium solutions with sterilized cotton swabs, is dipped into respectively in 4-6 of the embodiment of the present invention
The isopropanol water solution and mass percent of liquid dressing, mass percent concentration for 0.2% are repaired in prepared wound sterilization
Concentration is 1% polyhexamethylene guanide aqueous solution, and soaking time respectively sets 10min, 30min, 1h, is then trained in beef extract-peptone
It supports in base (staphylococcus aureus, pseudomonas aeruginosa) and potato agar culture medium (candida albicans, surface of a wound Aspergillus)
Streak inoculation culture, each experiment are repeated three times.Observation whether there is colony growth after 7 days, and statistical result is shown in Table four.
It is 0.2% that table four, which is that wound sterilization repairs liquid dressing with mass percent concentration in 4-6 of the embodiment of the present invention,
Isopropanol water solution and the polyhexamethylene guanide aqueous solution bactericidal effect contrast table that mass percent concentration is 1%, pass through the table
It understands, the isopropanol water that the bactericidal effect specific mass percent concentration that liquid dressing is repaired in wound of the invention sterilization is 0.2%
Solution and mass percent concentration will get well for the bactericidal effect of 1% polyhexamethylene guanide aqueous solution.
Liquid dressing is repaired in the wound sterilization of the embodiment 4-6 prepared by special process of the present invention can realize each group
That divides is compatible, and by maintaining the original function of each component, wound healing can be promoted and ooze out by being capable of providing one kind, also
It can antibacterial aseptic wound sterilization reparation liquid dressing.
Table four
The isopropanol that liquid dressing is repaired in wound sterilization with mass percent concentration is 0.2% in 4-6 of the embodiment of the present invention
Aqueous solution and the polyhexamethylene guanide aqueous solution bactericidal effect contrast table that mass percent concentration is 1%
Disappeared in conclusion the present invention is this with the sterilization of water soluble amino polysaccharide, disinfection preservative and high molecular polymer
Toxic agent is main active, the double emulsification systems with sterilization repair function being made of using macromolecule emulsifier emulsifier
Solution can be used in the flushing and soak of empyrosis wound surface, be that one kind can promote wound healing and ooze out, moreover it is possible to antibacterial
Liquid dressing is repaired in aseptic more effect wound sterilizations.The water soluble amino polysaccharide emulsified solution that includes of the present invention is prepared, is anti-
Bacterium compound emulsified solution is prepared, double emulsified solution systems compounding, the preparation method of four steps of sterilizing are capable of providing the wound sterilization
Repair liquid dressing.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the scope of the present invention.It is all
Any modifications, equivalent replacements and improvements are made within the spirit and principles in the present invention, are all contained in protection scope of the present invention
It is interior.
Claims (4)
1. liquid dressing is repaired in a kind of sterilization of wound, it is characterised in that it be with water soluble amino polysaccharide, disinfection preservative and
High molecular polymer disinfection sanitizer is main active, using macromolecule emulsifier by what emulsifier was formed there is sterilization to repair
Double emulsification system solution of multiple function, quality formula are as follows：
The water soluble amino polysaccharide is carboxyl chitosan or carboxymethyl chitosan；The disinfection preservative sterilizes anti-corrosion for alcohols
Agent；The high molecular polymer disinfection sanitizer is guanidine disinfection sanitizer；The macromolecule emulsifier is non-ionic high score
Sub- emulsifier；
The alcohols disinfection preservative is Phenoxyethanol or isopropanol；The guanidine disinfection sanitizer for poly hexamethylene biguanide or
Polyhexamethylene guanide；The non-ionic macromolecule emulsifier is polyvinylpyrrolidone or poloxamer.
2. liquid dressing is repaired in wound sterilization as described in claim 1, it is characterised in that quality formula is as follows：
3. liquid dressing is repaired in wound sterilization as described in claim 1, it is characterised in that quality formula is as follows：
4. as the preparation method of liquid dressing is repaired in the sterilization of any one wound in claim 1-3, it is characterised in that the preparation
Method includes：
(1) water soluble amino polysaccharide is added in purified water, under 50 DEG C~100 DEG C water bath conditions, water solubility is made by stirring
Glycosaminoglycan is completely dissolved in purified water, then, under 50 DEG C~100 DEG C water bath conditions and keeps the stirring of liquid 50
Rev/min or more, macromolecule emulsifier is added in into liquid, continues to stir, makes emulsified solution mixing abundant, obtains homogeneous water
Dissolubility glycosaminoglycan emulsified solution, it is spare；
(2) first high molecular polymer disinfection sanitizer is put into purified water, under 50 DEG C~100 DEG C water bath conditions, passes through stirring
High molecular polymer disinfection sanitizer is made to be completely dissolved in purified water, then under 50 DEG C~100 DEG C water bath conditions and is kept
The stirring of liquid adds in macromolecule emulsifier, continues to stir at 50 revs/min or more, makes emulsified solution mixing abundant, Zhi Hou
Under 50 DEG C~100 DEG C water bath conditions, the disinfection preservative of addition is uniformly mixed that can obtain homogeneous antibiotic complex emulsification molten
Liquid, it is spare；
(3) under 50 DEG C~100 DEG C water bath conditions, water soluble amino polysaccharide emulsified solution and antibiotic complex emulsified solution are kept
In any one solution under 50 revs/min or more of stirring, by water soluble amino polysaccharide emulsified solution and antibiotic complex
Another solution in emulsified solution is added thereto with being no more than the speed of 20 ml/mins, is uniformly mixed, and obtains double emulsifications
System solution；
(4) by after double emulsification system solution are dispensed obtained by step (3), under conditions of 115 DEG C of temperature or more and F0 value >=8
It carries out moist heat sterilization and sterilizes reparation liquid dressing up to wound.
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| CN105727357A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN105727356A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN106377793A (en) * | 2016-11-16 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Compound liquid dressing and preparation method thereof |
| CN109464696A (en) * | 2018-12-05 | 2019-03-15 | 福建易元生物医药有限公司 | A kind of atomizing liquid adhesive bandage |
| CN114159616A (en) * | 2022-02-14 | 2022-03-11 | 铂生卓越生物科技（北京）有限公司 | Liquid dressing for promoting wound repair and preparation method thereof |
| CN115350317B (en) * | 2022-08-30 | 2024-04-02 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
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| WO2003092756A1 (en) * | 2002-04-30 | 2003-11-13 | Her Majesty The Queen, In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Multi-layer synthetic dressing with cooling characteristics |
| US20040153040A1 (en) * | 2003-02-05 | 2004-08-05 | Lucie Martineau | Multi-layer synthetic dressing with cooling characteristics |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102335451B (en) * | 2011-09-15 | 2014-04-09 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
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Denomination of invention: Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing Effective date of registration: 20191212 Granted publication date: 20180601 Pledgee: Bank of Guiyang, Limited by Share Ltd directly under the sub branch Pledgor: Guizhou Yangsheng Medical Instrument Co., Ltd. Registration number: Y2019520000014 |