CN105079858A - Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing - Google Patents
Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing Download PDFInfo
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- CN105079858A CN105079858A CN201510484327.5A CN201510484327A CN105079858A CN 105079858 A CN105079858 A CN 105079858A CN 201510484327 A CN201510484327 A CN 201510484327A CN 105079858 A CN105079858 A CN 105079858A
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Abstract
The invention discloses liquid dressing capable of sterilizing and repairing wounds and a production method of the liquid dressing. The liquid dressing is double-emulsion-system solution using water-soluble amino polysaccharide, sterilizing preservatives and high-molecular polymer as main active constituents and high-molecular emulsifier as the emulsifier. The liquid dressing has the advantages that the liquid dressing can promote wound healing, resist exudation, inhibit bacteria and prevent infection and is applicable to washing or wet dressing treatment of related wounds such as scald wounds, knife wounds and chronic infection wounds. The production method of the liquid dressing includes: preparing water-soluble amino polysaccharide emulsion solution, preparing antibacterial compound emulsion solution, compounding a double-emulsion system and sterilizing.
Description
Technical field
The present invention relates to medical drugs, furthermore, relate to the sterilization of a kind of wound and repair liquid dressing and method for making thereof.
Technical background
The water soluble amino polysaccharide such as low molecular chitosan, chitosan hydrochlorate, chitosan quaternary ammonium salt, using carboxyl chitosan, carboxymethyl chitosan, hydroxypropyl chitosan are the good biomaterials of histocompatibility, the formation of granulation and tissue can be promoted, there is antiinflammatory exudation effect, flushing or the soak of animal large area open wound can be used for.Using carboxyl chitosan wherein or carboxymethyl chitosan are the soluble derivatives of chitosan, are poly-aminocarboxylated polysaccharide, are also polyampholytes.Itself is nontoxic, nonirritant, without challeng.In water soluble amino polysaccharide, there is a large amount of free amino group and carboxyl, therefore itself there is more weak natural bacteriostatic active, strengthening its antibiotic property will make its application more extensive, but due to the amphiphilic polymers characteristic of himself, can flocculate with a lot of polyanionic compound or polycationic compounds in the solution, make the difficulty being improved using carboxyl chitosan solution antibiotic property by the mode composite with other materials very large.
Glutaraldehyde, benzoic acid, phenoxyethanol, isopropyl alcohol, benzylalcohol, methaform, 2, the disinfection preservatives such as 4 chlorobenzyl alcohols, 2-phenyl phenol have stronger killing action to bacillus pyocyaneus, to other gram negative bacteria and positive bacteria effect more weak.Can be used for the surface injury for the treatment of charrin's disease, burn and pus infections.Be typically used as the antiseptic of cosmetics, vaccine and medicine.Phenoxyethanol is a kind of colourless oily liquids by ethylene glycol and menthylphenoxypolyethoxy ethanol, belongs to a kind of alcohols disinfection preservative.But, in prior art not by disinfection preservative and other materials composite to provide the technology of many effects liquid.
Polyhexamethylene guanidine, poly hexamethylene biguanide, pungent bacterium amine, polylysine and the contour Molecularly Imprinted Polymer disinfection sanitizer of its esters are wide spectrum disinfective agents, have the excellent characteristics such as valid density is low, speed of action fast, stable in properties.
Poly hexamethylene biguanide wherein and PHMB, have premium properties soluble in water, can use at normal temperatures.Can antibacterial for a long time and have no side effect, non-corrosiveness, colourless, odorless, nontoxic, do not fire, not quick-fried, use safety, can be described as a kind of environment-friendly type macromolecule polymer disinfection sanitizer of the best.Its sterilization mechanism is: can produce ionization in aqueous, and strong electropositive is contained at its hydrophilic group position, and absorption, usually in electronegative each bacterioid, cell entry cell membrane, suppresses the synthesis of film lactone plastid, causes thalline apoptosis.
This material is widely used in the antibacterial or sterilization of various aspects in industry, agricultural, medical and daily life.But, in prior art not by high molecular polymer disinfection sanitizer and other materials composite to provide the technology of many effects liquid.
The macromolecule emulsifiers such as polyisobutylene succinic acid sorbitol ester, poloxamer, polyvinylpyrrolidone, alkyl polyglucoside APG have excellent physiological inertia, do not participate in human metabolism, there is excellent biocompatibility, any stimulation is not formed to skin, mucosa, eye etc.; Also there is removing toxic substances, stop blooding, improve concentration of ordinary dissolution, prevent peritoneal adhesion, promote the effects such as erythrocyte sedimentation rate.Extensively applied in these and the closely-related field of health of people at medicine, food, cosmetics.
Polyvinylpyrrolidone in macromolecule emulsifier and PVP are a kind of non-ionic macromolecule compounds, are N vinylamide polymers.PVP or poloxamer are as a kind of synthesizing water-solubility macromolecular compound; it is a kind of high molecular surfactant simultaneously; can be used as dispersant, emulsifying agent, thickening agent, levelling agent, particle size modifier, there is colloid protective effect, film property, caking property, hygroscopicity, solubilising or cohesion.But, in prior art not by macromolecule emulsifier and other materials composite to provide the technology of many effects liquid.
To sum up, do not have in prior art water soluble amino polysaccharide, disinfection preservative, high molecular polymer disinfection sanitizer, macromolecule emulsifier and purified water material to be carried out composite thus a kind of technical scheme simultaneously possessing the mixture of above-mentioned substance properties is provided.
Wound particularly burn and scald is a kind of traumatic disease of being caused injury by extraneous factors such as fire, water, electricity, and burn or the degree difference of scalding, the weight of causing injury differs.Light injured skin, heavy muscle injury, heavier damage muscles and bones, no matter the burn and scald of weight, all needs to carry out active treatment process.
The medicine of current treatment wound particularly burn and scald, mainly medicine for external use.There are paste, liquid, powder shape etc.It is preferred that liquid, main feature is no pain of changing dressings of adding medicine to.In these Common drugs, the modes such as its common medical mechanism is prevention infection, wound healing, be accelerated into crust and blood circulation promoting and blood stasis dispelling, sorptivety control is wet.Common medicine is as moist expose burn ointment, JINGWANHONG ointment for scald, Glycyrrhiza Oil Compound, Kangfuxin Liquid etc.
But prior art is failed to provide to have and is promoted that burn and scald heals effect, again can exudation, can also antibacterial aseptic many effects medicine.
Summary of the invention
The invention provides one and can promote wound healing, again can exudation, antibacterial aseptic many effects wound sterilization can also repair liquid dressing and preparation method thereof.
For achieving the above object, technical scheme of the present invention is achieved in that
The invention discloses the sterilization of a kind of wound and repair liquid dressing, it is for main active with water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer, take macromolecule emulsifier as two emulsification system solution with the repair function that sterilizes that emulsifying agent is formed, its quality formula is as follows:
Alternatively, described water soluble amino polysaccharide is using carboxyl chitosan or carboxymethyl chitosan;
Alternatively, described disinfection preservative is alcohols disinfection preservative;
Alternatively, described high molecular polymer disinfection sanitizer is guanidine class disinfection sanitizer;
Alternatively, described macromolecule emulsifier is nonionic macromolecule emulsifier;
Alternatively, described alcohols disinfection preservative is phenoxyethanol or isopropyl alcohol;
Alternatively, described guanidine class disinfection sanitizer is poly hexamethylene biguanide or polyhexamethylene guanidine;
Alternatively, described nonionic macromolecule emulsifier is polyvinylpyrrolidone or poloxamer;
Alternatively, the quality formula of described wound sterilization reparation liquid dressing is as follows:
Alternatively, the quality formula of described wound sterilization reparation liquid dressing is as follows:
The invention also discloses the sterilization of a kind of wound and repair liquid dressing preparation method, the method comprises:
(1) water soluble amino polysaccharide is added in purified water, under 50 DEG C ~ 100 DEG C water bath condition, by stirring, water soluble amino polysaccharide is dissolved in purified water completely, then, under 50 DEG C ~ 100 DEG C water bath condition and keep liquid be stirred in more than 50 revs/min, in liquid, add macromolecule emulsifier, continue to stir, emulsified solution is mixed fully, obtains homogeneous water soluble amino polysaccharide emulsified solution, for subsequent use;
(2) first high molecular polymer disinfection sanitizer is put into purified water, under 50 DEG C ~ 100 DEG C water bath condition, by stirring, high molecular polymer disinfection sanitizer is dissolved in purified water completely, then under 50 DEG C ~ 100 DEG C water bath condition and keep liquid be stirred in more than 50 revs/min, add macromolecule emulsifier, continue to stir, emulsified solution is made to mix fully, afterwards under 50 DEG C ~ 100 DEG C water bath condition, the disinfection preservative added, mix homogeneously can obtain homogeneous antibiotic complex emulsified solution, for subsequent use;
(3) under 50 DEG C ~ 100 DEG C water bath condition, under keeping the stirring more than 50 revs/min of any one solution in water soluble amino polysaccharide emulsified solution and antibiotic complex emulsified solution, another kind of solution in water soluble amino polysaccharide emulsified solution and antibiotic complex emulsified solution is joined wherein with the speed being no more than 20 ml/min, mix homogeneously, obtains two emulsification system solution;
(4), after two for step (3) gained emulsification system solution being carried out subpackage, carry out moist heat sterilization under the condition of F0 value >=8 and namely obtain wound temperature more than 115 DEG C and to sterilize reparation liquid dressing.
From above-mentioned, the present invention this with water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer for main active, the two emulsification system solution with sterilization repair function formed for emulsifying agent with macromolecule emulsifier can be used in flushing and the soak of empyrosis wound surface, that one can promote wound healing, again can exudation, antibacterial aseptic many effects wound sterilization can also repair liquid dressing.Of the present inventionly comprise water soluble amino polysaccharide emulsifying solution preparation, the preparation of antibiotic complex emulsified solution, two emulsified solution system method for making that is composite, sterilizing four step can provide the sterilization of described wound to repair liquid dressing.
Detailed description of the invention
Core concept of the present invention is: adopt Technology of the present invention, by the preparation of water soluble amino polysaccharide emulsified solution, the preparation of antibiotic complex emulsified solution, composite and sterilizing four step of two emulsified solution system, by the water soluble amino polysaccharide being originally difficult to coexist in same system, disinfection preservative, high molecular polymer disinfection sanitizer, macromolecule emulsifier and purified water are re-dubbed liquid dressing, liquid dressing of the present invention can retain an original characteristic of component, liquid dressing of the present invention is had and can promote wound healing, again can exudation, can also antibacterial aseptic multi-efficiency.
In the present invention, similar nature the water soluble amino polysaccharide of phase trans-substitution can comprise low molecular chitosan, chitosan hydrochlorate, chitosan quaternary ammonium salt, using carboxyl chitosan, carboxymethyl chitosan, hydroxypropyl chitosan etc.
In the present invention, similar nature the disinfection preservative of phase trans-substitution can comprise glutaraldehyde, benzoic acid, phenoxyethanol, isopropyl alcohol, benzylalcohol, methaform, 2,4 chlorobenzyl alcohols, 2-phenyl phenol etc.
In the present invention, similar nature the high molecular polymer disinfection sanitizer of phase trans-substitution can comprise polyhexamethylene guanidine, poly hexamethylene biguanide, pungent bacterium amine, polylysine and its esters etc.
In the present invention, similar nature the macromolecule emulsifier of phase trans-substitution can comprise polyisobutylene succinic acid sorbitol ester, poloxamer, polyvinylpyrrolidone, alkyl polyglucoside APG etc.
For making the object, technical solutions and advantages of the present invention clearly, will be described in further detail embodiment of the present invention by embodiment below.
By the medicine of following technique according to the formulated embodiment 1-3 of table one:
Under 80 DEG C of water bath condition, using carboxyl chitosan is dissolved in purified water completely, keep liquid under 80 DEG C of water bath condition and under maintaining the stirring of more than 50 revs/min, add polyvinylpyrrolidone, continue stirring 10 ~ 60 minutes, emulsified solution is mixed fully, obtains using carboxyl chitosan emulsified solution, for subsequent use.
Under 80 DEG C of water bath condition, after poly hexamethylene biguanide being put into purified water dissolving, keep liquid under 80 DEG C of water bath condition and under maintaining the stirring of more than 50 revs/min, add polyvinylpyrrolidone, continuing stirring 10 ~ 60 minutes, emulsified solution is made to mix fully, then under maintaining the stirring of more than 50 revs/min, in emulsified solution, phenoxyethanol is added, mix homogeneously 80 DEG C of water bath condition, obtain homogeneous antibiotic complex emulsified solution, for subsequent use.
Under 80 DEG C of water bath condition, under keeping the stirring of using carboxyl chitosan emulsified solution more than 50 revs/min, above-mentioned antibiotic complex emulsified solution to be joined in using carboxyl chitosan emulsified solution (under also can keeping the stirring of antibiotic complex emulsified solution more than 50 revs/min with the speed of 10 ml/min, using carboxyl chitosan emulsified solution is joined in antibiotic complex emulsified solution with the speed of 10 ml/min), mix homogeneously can carry out sealed packaging.Through more than 115 DEG C after sealed packaging, namely obtain wound of the present invention sterilization after the moist heat sterilization of F0 value >=8 and repair liquid dressing.
In embodiment of the present invention 1-3, using carboxyl chitosan a kind ofly has biological activity and the water soluble amino polysaccharide of range of viscosities between 10mpas ~ 80mpas, can promote that burning soup hinders wound healing, has antiinflammatory exudation effect, plays wound surface reparation, exudation function in liquid dressing.
In embodiment of the present invention 1-3, poly hexamethylene biguanide and phenoxyethanol are by the composite sterilizing function providing liquid dressing of the present invention.Staphylococcus aureus in the gram-positive cocci common to empyrosis wound surface, the Pseudomonas aeruginosa in gram negative bacteria, and Candida albicans, wound surface aspergillosis fungistatic effect better.Be applicable to flushing or the soak treatment of the relevant wound surface aspects such as burn and scald, knife injury and chronic infection wound surface.
In embodiment of the present invention 1-3, macromolecule emulsifier polyvinylpyrrolidone is emulsifying agent in the solution, can play again removing toxic substances, hemostasis, promote the effects such as erythrocyte sedimentation rate.
[table]
The formula of embodiment of the present invention 1-3
Liquid dressing is repaired in the wound sterilization prepared in embodiment 1-3, the phenoxyethanol aqueous solution, the mass percent concentration that are 0.05% with mass percent concentration be 0.02% poly hexamethylene biguanide aqueous solution together carry out the contrast test of bactericidal effect, the strain selected is staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, wound surface aspergillosis these 4 kinds, and its bacterium colony concentration is all diluted to 1 × 10
4cFU/ml, this 4 kinds of bacterium liquid are dipped with sterilized cotton swabs, be dipped into respectively the wound sterilization prepared in embodiment 1-3 repair liquid dressing, mass percent concentration be 0.05% phenoxyethanol aqueous solution and mass percent concentration be in the poly hexamethylene biguanide aqueous solution of 0.02%, soak time respectively establishes 10min, 30min, 1h, then cultivate at beef-protein medium (staphylococcus aureus, Pseudomonas aeruginosa) and the upper streak inoculation of potato agar culture medium (Candida albicans, wound surface aspergillosis), each experiment repetition 3 times.Observe after 7 days with or without colony growth, statistical result is in table two.
Table two is the poly hexamethylene biguanide aqueous solution bactericidal effect contrast table of the made liquid dressing of embodiment of the present invention 1-3 and 0.05% phenoxyethanol aqueous solution and 0.02%, known by this table, the bactericidal effect of the bactericidal effect specific mass percent concentration that liquid dressing is repaired in wound of the present invention sterilization to be 0.05% phenoxyethanol aqueous solution or mass percent concentration the be poly hexamethylene biguanide aqueous solution of 0.02% will be got well.
The wound sterilization of the embodiment 1-3 namely prepared by special process of the present invention is repaired liquid dressing and can be realized the compatible of each component, maintain again the original function of each component, one can be provided to promote wound healing, again can exudation, antibacterial aseptic wound sterilization can also repair liquid dressing.
Table two
The made liquid dressing of embodiment 1-3 and 0.05% phenoxyethanol aqueous solution and 0.02% poly hexamethylene biguanide aqueous solution bactericidal effect contrast table
By the medicine of following technique according to the formulated embodiment of the present invention 4-6 of table three:
Under 80 DEG C of water bath condition, by stirring, carboxymethyl chitosan is dissolved completely in purified water, under keeping the stirring of liquid under 80 DEG C of water bath condition and more than 50 revs/min, add poloxamer, continue stirring 10 ~ 60 minutes, emulsified solution is mixed fully, obtains carboxymethyl chitosan emulsified solution, for subsequent use.
Under 80 DEG C of water bath condition, after polyhexamethylene guanidine being dissolved in purified water by stirring, then under 50 DEG C ~ 100 DEG C water bath condition and keep liquid be stirred in the stirring of more than 50 revs/min under, add poloxamer, continuation stirring 10 ~ 60 minutes, emulsified solution is made to mix fully, afterwards under 80 DEG C of water bath condition, in emulsified solution, add isopropyl alcohol, mix homogeneously, obtain antibiotic complex emulsified solution, for subsequent use.
Under 80 DEG C of water bath condition, under keeping the stirring of carboxymethyl chitosan emulsified solution more than 50 revs/min, above-mentioned antibiotic complex emulsified solution to be joined in carboxymethyl chitosan emulsified solution (under also can keeping the stirring of antibiotic complex emulsified solution more than 50 revs/min with the speed of 10 ml/min, above-mentioned carboxymethyl chitosan emulsified solution is joined in antibiotic complex emulsified solution with the speed of 10 ml/min), mix homogeneously can carry out sealed packaging.Through more than 115 DEG C after sealed packaging, namely obtain wound of the present invention sterilization after the moist heat sterilization of F0 value >=8 and repair liquid dressing.
In embodiment of the present invention 4-6, carboxymethyl chitosan a kind ofly has biological activity and the water soluble amino polysaccharide of range of viscosities between 10mpas ~ 80mpas, can promote that burning soup hinders wound healing, has antiinflammatory exudation effect, plays wound surface reparation, exudation function in liquid dressing.
In embodiment of the present invention 4-6, polyhexamethylene guanidine and isopropyl alcohol are by the composite sterilizing function providing liquid dressing of the present invention.Staphylococcus aureus in the gram-positive cocci common to empyrosis wound surface, the Pseudomonas aeruginosa in gram negative bacteria, and Candida albicans, wound surface aspergillosis fungistatic effect better.Be applicable to flushing or the soak treatment of the relevant wound surface aspects such as burn and scald, knife injury and chronic infection wound surface.
In embodiment of the present invention 4-6, macromolecule emulsifier poloxamer is emulsifying agent in the solution, can play again removing toxic substances, hemostasis, promote the effects such as erythrocyte sedimentation rate.
[table three]
The formula of embodiment of the present invention 4-6
Liquid dressing is repaired in the wound sterilization prepared in above-described embodiment 4-6, with mass percent concentration be 0.2% isopropanol water solution and mass percent concentration be 1% polyhexamethylene guanidine aqueous solution together carry out the contrast test of bactericidal effect, the strain selected is staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, wound surface aspergillosis these 4 kinds, and its bacterium colony concentration is all diluted to 1 × 10
4cFU/ml, this 4 kinds of bacterium liquid are dipped with sterilized cotton swabs, be dipped into respectively the wound sterilization prepared in embodiment of the present invention 4-6 repair liquid dressing, mass percent concentration be 0.2% isopropanol water solution and mass percent concentration be 1% polyhexamethylene guanidine aqueous solution, soak time respectively establishes 10min, 30min, 1h, then cultivate at beef-protein medium (staphylococcus aureus, Pseudomonas aeruginosa) and the upper streak inoculation of potato agar culture medium (Candida albicans, wound surface aspergillosis), each experiment all in triplicate.Observe after 7 days with or without colony growth, statistical result is in table four.
Table four for wound sterilization in embodiment of the present invention 4-6 repair liquid dressing and mass percent concentration be 0.2% isopropanol water solution and mass percent concentration be 1% polyhexamethylene guanidine aqueous solution bactericidal effect contrast table, known by this table, the bactericidal effect specific mass percent concentration that liquid dressing is repaired in wound of the present invention sterilization be 0.2% isopropanol water solution and mass percent concentration be that the bactericidal effect of the polyhexamethylene guanidine aqueous solution of 1% will be got well.
The wound sterilization of the embodiment 4-6 namely prepared by special process of the present invention is repaired liquid dressing and can be realized the compatible of each component, by maintaining the original function of each component, one can be provided to promote wound healing, again can exudation, antibacterial aseptic wound sterilization can also repair liquid dressing.
Table four
In the embodiment of the present invention 4-6 wound sterilization repair liquid dressing and mass percent concentration be 0.2% isopropanol water solution and mass percent concentration be 1% polyhexamethylene guanidine aqueous solution bactericidal effect contrast table
In sum, the present invention this with water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer for main active, the two emulsification system solution with sterilization repair function formed for emulsifying agent with macromolecule emulsifier can be used in flushing and the soak of empyrosis wound surface, that one can promote wound healing, again can exudation, antibacterial aseptic many effects wound sterilization can also repair liquid dressing.Of the present inventionly comprise water soluble amino polysaccharide emulsifying solution preparation, the preparation of antibiotic complex emulsified solution, two emulsified solution system method for making that is composite, sterilizing four step can provide the sterilization of described wound to repair liquid dressing.
The foregoing is only preferred embodiment of the present invention, be not intended to limit protection scope of the present invention.All any amendments done within the spirit and principles in the present invention, equivalent replacement, improvement etc., be all included in protection scope of the present invention.
Claims (11)
1. liquid dressing is repaired in a wound sterilization, it is characterized in that it is for main active with water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer, take macromolecule emulsifier as two emulsification system solution with the repair function that sterilizes that emulsifying agent is formed, its quality formula is as follows:
2. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that described water soluble amino polysaccharide is using carboxyl chitosan or carboxymethyl chitosan.
3. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that described disinfection preservative is alcohols disinfection preservative.
4. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that described high molecular polymer disinfection sanitizer is guanidine class disinfection sanitizer.
5. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that described macromolecule emulsifier is nonionic macromolecule emulsifier.
6. liquid dressing is repaired in wound sterilization as claimed in claim 3, it is characterized in that described alcohols disinfection preservative is phenoxyethanol or isopropyl alcohol.
7. liquid dressing is repaired in wound sterilization as claimed in claim 4, it is characterized in that described guanidine class disinfection sanitizer is poly hexamethylene biguanide or polyhexamethylene guanidine.
8. liquid dressing is repaired in wound sterilization as claimed in claim 5, it is characterized in that described nonionic macromolecule emulsifier is polyvinylpyrrolidone or poloxamer.
9. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that quality formula is as follows:
10. liquid dressing is repaired in wound sterilization as claimed in claim 1, it is characterized in that quality formula is as follows:
11. repair the preparation method of liquid dressing as any one wound in claim 1-11 sterilizes, and it is characterized in that this preparation method comprises:
(1) water soluble amino polysaccharide is added in purified water, under 50 DEG C ~ 100 DEG C water bath condition, by stirring, water soluble amino polysaccharide is dissolved in purified water completely, then, under 50 DEG C ~ 100 DEG C water bath condition and keep liquid be stirred in more than 50 revs/min, in liquid, add macromolecule emulsifier, continue to stir, emulsified solution is mixed fully, obtains homogeneous water soluble amino polysaccharide emulsified solution, for subsequent use;
(2) first high molecular polymer disinfection sanitizer is put into purified water, under 50 DEG C ~ 100 DEG C water bath condition, by stirring, high molecular polymer disinfection sanitizer is dissolved in purified water completely, then under 50 DEG C ~ 100 DEG C water bath condition and keep liquid be stirred in more than 50 revs/min, add macromolecule emulsifier, continue to stir, emulsified solution is made to mix fully, afterwards under 50 DEG C ~ 100 DEG C water bath condition, the disinfection preservative added, mix homogeneously can obtain homogeneous antibiotic complex emulsified solution, for subsequent use;
(3) under 50 DEG C ~ 100 DEG C water bath condition, under keeping the stirring more than 50 revs/min of any one solution in water soluble amino polysaccharide emulsified solution and antibiotic complex emulsified solution, another kind of solution in water soluble amino polysaccharide emulsified solution and antibiotic complex emulsified solution is joined wherein with the speed being no more than 20 ml/min, mix homogeneously, obtains two emulsification system solution;
(4), after two for step (3) gained emulsification system solution being carried out subpackage, carry out moist heat sterilization under the condition of F0 value >=8 and namely obtain wound temperature more than 115 DEG C and to sterilize reparation liquid dressing.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727357A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN105727356A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN106377793A (en) * | 2016-11-16 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Compound liquid dressing and preparation method thereof |
| CN109464696A (en) * | 2018-12-05 | 2019-03-15 | 福建易元生物医药有限公司 | A kind of atomizing liquid adhesive bandage |
| CN114159616A (en) * | 2022-02-14 | 2022-03-11 | 铂生卓越生物科技（北京）有限公司 | Liquid dressing for promoting wound repair and preparation method thereof |
| CN115350317A (en) * | 2022-08-30 | 2022-11-18 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003092756A1 (en) * | 2002-04-30 | 2003-11-13 | Her Majesty The Queen, In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Multi-layer synthetic dressing with cooling characteristics |
| US20040153040A1 (en) * | 2003-02-05 | 2004-08-05 | Lucie Martineau | Multi-layer synthetic dressing with cooling characteristics |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
-
2015
- 2015-08-10 CN CN201510484327.5A patent/CN105079858B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003092756A1 (en) * | 2002-04-30 | 2003-11-13 | Her Majesty The Queen, In Right Of Canada, As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Multi-layer synthetic dressing with cooling characteristics |
| US20040153040A1 (en) * | 2003-02-05 | 2004-08-05 | Lucie Martineau | Multi-layer synthetic dressing with cooling characteristics |
| CN102228715A (en) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | Liquid dressing containing chitosan derivative and preparation method thereof |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105727357A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN105727356A (en) * | 2016-02-19 | 2016-07-06 | 武汉沃德利派医疗器械有限公司 | Liquid dressing for wound |
| CN106377793A (en) * | 2016-11-16 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Compound liquid dressing and preparation method thereof |
| CN109464696A (en) * | 2018-12-05 | 2019-03-15 | 福建易元生物医药有限公司 | A kind of atomizing liquid adhesive bandage |
| CN114159616A (en) * | 2022-02-14 | 2022-03-11 | 铂生卓越生物科技（北京）有限公司 | Liquid dressing for promoting wound repair and preparation method thereof |
| CN115350317A (en) * | 2022-08-30 | 2022-11-18 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
| CN115350317B (en) * | 2022-08-30 | 2024-04-02 | 振德医疗用品股份有限公司 | Wound dressing composition and preparation method thereof |
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| CN105079858B (en) | 2018-06-01 |
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Denomination of invention: Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing Effective date of registration: 20191212 Granted publication date: 20180601 Pledgee: Bank of Guiyang, Limited by Share Ltd directly under the sub branch Pledgor: Guizhou Yangsheng Medical Instrument Co., Ltd. Registration number: Y2019520000014 |
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