CN105727356A - Liquid dressing for wound - Google Patents

Liquid dressing for wound Download PDF

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Publication number
CN105727356A
CN105727356A CN201610092793.3A CN201610092793A CN105727356A CN 105727356 A CN105727356 A CN 105727356A CN 201610092793 A CN201610092793 A CN 201610092793A CN 105727356 A CN105727356 A CN 105727356A
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CN
China
Prior art keywords
ml
content
wound
dressing
surgical dressing
Prior art date
Application number
CN201610092793.3A
Other languages
Chinese (zh)
Inventor
徐瑞土
Original Assignee
武汉沃德利派医疗器械有限公司
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Filing date
Publication date
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Priority to CN201610092793.3A priority Critical patent/CN105727356A/en
Publication of CN105727356A publication Critical patent/CN105727356A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0019Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Abstract

The invention provides a liquid dressing for a wound. The liquid dressing for the wound mainly comprises polyhexamethylene biguanidine hydrochloride and cocamidopropyl betaine, wherein the content of polyhexamethylene biguanidine hydrochloride is 0.1-1.5% g/ml, the content of cocamidopropyl betaine is 0.1-1.5% g/ml, and the balance is water. The liquid dressing is low in toxicity, good in tolerance, free of irritation, high in antibacterial activity and further has the effects of alleviating pain, reducing peculiar smell of the wound and promoting healing of the wound.

Description

The outer wound surgical dressing of liquid

Technical field

The present invention relates to medical instruments field, particularly relate to the outer wound surgical dressing of a kind of liquid.

Background technology

The skin soft tissue wounds such as open wound, soft tissue infection's ulceration mouth, operative incision, it is necessary to carry out treatment of wounds to ensure the cleaning of wound, aseptic, promote promote granulation growth, promote wound healing.For the process of above-mentioned wound, it is generally required to carry out debridement and process of changing dressings.And at debridement Cleaning Process wound and spread on the liquid wound treatment agent of wound surface when Wound during Dressing Change and be the outer wound surgical dressing of liquid.

The application of the outer wound surgical dressing of current liquid is very extensive, and this kind of dressing can make wound keep moist environment, and sterilizing is antibacterial, it is possible to effectively facilitates granulation tissue growth, promotes the healing of wound.Application comparison liquid wound dressing widely generally has silver ion dressing, chitosan dressing and chemosterilant dressing etc. several on the market at present.Silver ion dressing and chitosan dressing mainly using silver ion or chitosan as biocide, are aided with other dispensing.Through present medical research, silver ion and chitosan all have certain toxicity, although it all has good sterilizing and antibacterial effect, but skin soft tissue is all had and injures definitely, the health of patient can be worked the mischief by abuse, thus the control of current this kind of dressing is very strict.Chemosterilant dressing is then main with chemicals for biocide, equally also has good sterilizing and antibacterial effect.But current chemosterilant is primarily present problem below: first, most of chemicals all have certain zest, can increase the pain of patient, and some patients also has anaphylaxis;Secondly, most chemicals does not suppress and treatment effect for soft tissue transudate, uses this kind of dressing wound abnormal flavour bigger;Finally, chemical classes preparation generally all lacks the effect promoting granulation tissue growth, it is impossible to make wound healing.

Summary of the invention

The technical problem to be solved is aiming at the deficiency of above-mentioned background technology, there is provided a kind of liquid outer wound surgical dressing, there is low toxicity, good toleration, and nonirritant, there is relatively high antibacterial activity, moreover it is possible to have and slow down pain, reduction wound abnormal flavour and promote effect of wound healing.

For solving above-mentioned technical problem, the outer wound surgical dressing of liquid provided by the invention, the outer wound surgical dressing main component of described liquid includes hexamethylene and cocamido propyl betaine, wherein the content of hexamethylene is 0.1% ~ 1.5%g/ml, the content of cocamido propyl betaine is 0.1% ~ 1.5%g/ml, and all the other are water.

In technique scheme, the outer wound surgical dressing of described liquid also includes the preservative of 0.01% ~ 0.05%g/ml, the preferred benzalkonium chloride of preservative.

In technique scheme, the content of described hexamethylene preferably 0.15% ~ 0.85%g/ml, it is most preferred that 0.42% ~ 0.58%g/ml.

In technique scheme, the content of described cocamido propyl betaine preferably 0.15% ~ 0.85%g/ml, it is preferred that 0.52% ~ 0.62%g/ml, it is most preferred that 0.55% ~ 0.58%g/ml.

In technique scheme, described water most preferably purified water.

Compared with prior art, the beneficial effects of the present invention is: 1) adopt appropriate hexamethylene as biocide, while taking into account sterilizing and be antibacterial, it is ensured that dressing has low toxicity, good toleration, and sensitization is extremely low;2) use cocamido propyl betaine as surfactant, and have employed applicable consumption, zest is extremely low and has certain bactericidal effect concurrently, and this material can also keep wettability and the pliability of skin soft tissue, it is possible to wound healing has very strong facilitation;3) mixing of above two material uses, moreover it is possible to the abnormal flavour effectively reducing wound produces;4) showing through clinic, inventive formulation also has the effect of inhibition of pain sense, it is possible to effectively reduce the misery of patient.

Detailed description of the invention

It is described in further detail below in conjunction with specific embodiments of the invention:

The outer wound surgical dressing of liquid designed by the present invention, at debridement Cleaning Process wound and spread on wound surface when Wound during Dressing Change.The outer wound surgical dressing main component of described liquid includes hexamethylene and cocamido propyl betaine, wherein the content of hexamethylene is 0.1% ~ 1.5%g/ml, the content of cocamido propyl betaine is 0.1% ~ 1.5%g/ml, and all the other are water.In actual disposition process, due to the relation of material purity, inevitably also have certain impurity and exist.

Through inventor's clinical research for many years, hexamethylene has good sterilizing and antibacterial effect, is very suitable for for wound dressing.But the handle control for consumption is very crucial, and dosage is crossed conference and caused that it has toxicity and zest, the too small effect not reaching again preventing and treating wound infection of dosage.Inventor is after substantial amounts of sterilizing experiment and toxicity test, it has been found that hexamethylene content controls in 0.1% ~ 1.5%g/ml interval, it is possible to effectively play sterilizing and antibacterial effect, and the toxicity of water preparation is also within acceptable scope simultaneously.

When carrying out the studies above, inventor have found that the simple healing selecting hexamethylene can not well promote wound surface, thus select which kind of assistant medicament matched, also key very.After inventor have passed through substantial amounts of experiment and combination selection, it has been found that cocamido propyl betaine and hexamethylene can play good effect.In this stage research process, inventor have found that when the two combination uses, fungistatic effect is fairly obvious, when the two combination uses, it is possible to reduce the consumption of hexamethylene further, reduce the toxicity of wholly liquid state dressing.The content of hexamethylene is 0.1% ~ 1.5%g/ml, and when the content of cocamido propyl betaine is 0.1% ~ 1.5%g/ml, product has fabulous sterilization effect, and toxicity is also at meeting in the scope of clinical safety.Carry out in zoopery and clinical experiment process follow-up, inventor is also found surprisingly that both with the use of playing softening skin soft tissue, keeping the effect of wound moist degree, it is possible to promote wound healing, the two is utilized in conjunction with there is the effect reducing pain clinically simultaneously.And when adopting said ratio, the time of wound healing can shorten further.

Through the studies above, inventor optimizes formula further.

The content of hexamethylene preferably 0.15% ~ 0.85%g/ml in inventive formulation, it is most preferred that 0.42% ~ 0.58%g/ml.

The content of cocamido propyl betaine preferably 0.15% ~ 0.85%g/ml in inventive formulation, it is preferred that 0.52% ~ 0.62%g/ml, it is most preferred that 0.55% ~ 0.58%g/ml.

In order to prevent product of the present invention from going bad so that it is have the longer shelf-life;And also to sterilization effect can be reached with relatively low sterilizing parameter as much as possible in product sterilizing, packaging process, it is to avoid during sterilizing, product composition is decomposed or reacted and causes product failure.Inventor studies discovery, it is possible to add a certain amount of preservative to realize above-mentioned purpose.The addition of preservative should control within the scope of 0.01% ~ 0.05%g/ml, measured the purpose not reaching anti-metamorphic at least, measures excessive, can affect toxicity and the sensitization of product, and the content range of 0.01% ~ 0.05%g/ml is most widely suited.And preservative ingredient can be phenoxyethanol, benzalkonium bromide etc., it is preferred to use benzalkonium chloride.

The preferred purified water of water in the present invention.

The embodiment of the present invention:

Embodiment 1: the outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.1%g/ml, cocamido propyl betaine content is 0.1%g/ml.Added wet concentration distilled water.Finally encapsulation, sterilizing obtains final products.

Embodiment 2:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.15%g/ml, cocamido propyl betaine content is 0.24%g/ml.Added wet concentration distilled water.Finally encapsulation, sterilizing obtains final products.

Embodiment 3:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.22%g/ml, cocamido propyl betaine content is 0.15%g/ml.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 4:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.42%g/ml, cocamido propyl betaine content is 0.52%g/ml.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 5:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.58%g/ml, cocamido propyl betaine content is 0.62%g/ml.The benzalkonium chloride of 0.05%g/ml it is also added with in above-mentioned wound dressing.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 6:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.55%g/ml, cocamido propyl betaine content is 0.55%g/ml.The benzalkonium chloride of 0.04%g/ml it is also added with in above-mentioned wound dressing.Added wet concentration distilled water.Finally encapsulation, sterilizing obtains final products.

Embodiment 7:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.45%g/ml, cocamido propyl betaine content is 0.58%g/ml.The benzalkonium chloride of 0.03%g/ml it is also added with in above-mentioned wound dressing.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 8:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.85%g/ml, cocamido propyl betaine content is 0.85%g/ml.The benzalkonium chloride of 0.02%g/ml it is also added with in above-mentioned wound dressing.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 9:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adds water and is configured to solution shape so that it is middle hexamethylene content is 1.2%g/ml, and cocamido propyl betaine content is 1.2%g/ml.The benzalkonium chloride of 0.01%g/ml it is also added with in above-mentioned wound dressing.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 10:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adds water and is configured to solution shape so that it is middle hexamethylene content is 1.5%g/ml, and cocamido propyl betaine content is 1%g/ml.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 11:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adds water and is configured to solution shape so that it is middle hexamethylene content is 1%g/ml, and cocamido propyl betaine content is 1.5%g/ml.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Embodiment 12:The outer wound surgical dressing of a kind of liquid, including hexamethylene and cocamido propyl betaine, adding water and be configured to solution shape so that it is middle hexamethylene content is 0.48%g/ml, cocamido propyl betaine content is 0.56%g/ml.Added wet concentration purified water.Finally encapsulation, sterilizing obtains final products.

Application examples of the present invention:

Zoopery 1:With embodiment of the present invention product, rabbit carrying out wound surface cleaning and stick experiment, result shows: experimental rabbit is showed no the symptoms such as discharge, erythema, edema;Tissue slice is observed and is shown, shows no obvious abnormalities.It is judged to nonirritant product.

Zoopery 2:With embodiment of the present invention product, Cavia porcellus is carried out closing and stick test, carry out system test and scoring according to the relevant regulations of GB/T16866,10-2005.Result shows: experimental guinea pig all occurred without delayed hypersensitivity in 48 hours.

Zoopery 3:With embodiment of the present invention product for experimental group product, with the chitosan dressing generally sold on the market and chemicals dressing for matched group product, rabbit carrying out wound surface cleaning and stick experiment, result shows: adopt the wound healing time of the experimental group rabbit of product of the present invention to shorten more than 20% than matched group rabbit.

Clinical practice example:Carrying out clinical research under meeting country's relevant laws and regulations premise, result shows: being used alone this product and can improve rapidly the wound situation of patient, infection rate substantially reduces, and after not finding to apply this product, allergy or systemic reaction occurs.Patient generally experiences comfortable, it is easy to accept, and after patient generally feels to use this product, pain has obvious improvement.

The core of the present invention is to utilize hexamethylene and cocamido propyl betaine to prepare the outer wound surgical dressing of liquid for main component; play preventing and treating wound infection; promote wound healing; and the effect that effectively reduction of patient is painful; therefore; on the basis of the principle of the invention, any change utilizing above-mentioned mechanism or deformation, belong to protection scope of the present invention.

Claims (10)

1. the outer wound surgical dressing of liquid, for at debridement Cleaning Process wound and spread on wound surface when Wound during Dressing Change, it is characterized in that: the outer wound surgical dressing main component of described liquid includes hexamethylene and cocamido propyl betaine, wherein the content of hexamethylene is 0.1% ~ 1.5%g/ml, the content of cocamido propyl betaine is 0.1% ~ 1.5%g/ml, and all the other are water.
2. the outer wound surgical dressing of liquid according to claim 1, it is characterised in that: the outer wound surgical dressing of described liquid also includes the preservative of 0.01% ~ 0.05%g/ml.
3. the outer wound surgical dressing of liquid according to claim 2, it is characterised in that: described preservative is benzalkonium chloride.
4. the outer wound surgical dressing of liquid according to claim 1, it is characterised in that: the content of described hexamethylene is 0.15% ~ 0.85%g/ml.
5. the outer wound surgical dressing of liquid according to claim 4, it is characterised in that: the content of described hexamethylene is 0.42% ~ 0.58%g/ml.
6. the outer wound surgical dressing of liquid according to claim 1 ~ 5, it is characterised in that: the content of described cocamido propyl betaine is 0.15% ~ 0.85%g/ml.
7. the outer wound surgical dressing of liquid according to claim 6, it is characterised in that: the content of described cocamido propyl betaine is 0.52% ~ 0.62%g/ml.
8. the outer wound surgical dressing of liquid according to claim 7, it is characterised in that: the content of described cocamido propyl betaine is 0.55% ~ 0.58%g/ml.
9. the outer wound surgical dressing of liquid according to claim 1 ~ 5, it is characterised in that: described water is purified water.
10. the outer wound surgical dressing of liquid according to claim 6, it is characterised in that: described water is purified water.
CN201610092793.3A 2016-02-19 2016-02-19 Liquid dressing for wound CN105727356A (en)

Priority Applications (1)

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CN201610092793.3A CN105727356A (en) 2016-02-19 2016-02-19 Liquid dressing for wound

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260251A1 (en) * 2004-05-07 2005-11-24 Resorba Wundversorgung Gmbh & Co. Kg Bio-absorbable collagen-based wound dressing
CN101461368A (en) * 2008-12-22 2009-06-24 南车戚墅堰机车车辆工艺研究所有限公司 Spray finishing material with disinfecting and sterilizing functions
CN105079858A (en) * 2015-08-10 2015-11-25 贵州扬生医用器材有限公司 Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260251A1 (en) * 2004-05-07 2005-11-24 Resorba Wundversorgung Gmbh & Co. Kg Bio-absorbable collagen-based wound dressing
CN101461368A (en) * 2008-12-22 2009-06-24 南车戚墅堰机车车辆工艺研究所有限公司 Spray finishing material with disinfecting and sterilizing functions
CN105079858A (en) * 2015-08-10 2015-11-25 贵州扬生医用器材有限公司 Liquid dressing capable of sterilizing and repairing wounds and production method of liquid dressing

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Application publication date: 20160706

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