CN103520767B - A kind of antibacterial heal-promoting aerogel dressing and preparation method thereof - Google Patents
A kind of antibacterial heal-promoting aerogel dressing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of antibacterial heal-promoting aerogel dressing and preparation method thereof.This dressing is mainly composed of water miscible high molecular polymer, has pseudoplastic functional polymer, antibacterial and water, it molten is integrated through series of process, and solution is poured into a mould in a mold, obtains through irradiation sterilization after solidification.Wound healing test, the In vitro Bactericidal Experiments test result display present invention can effectively facilitate wound healing, and have preferable bacteriostatic activity (sterilizing rate reaches more than 70%) to various bacteria.The antibacterial heal-promoting aerogel dressing of the present invention is substantially better than existing aerogel dressing, there is the advantages such as antibacterial evident in efficacy, transparent, water content is high, preparation method is simple, products pure, nontoxic, non-stimulated, good biocompatibility, suit large area to popularize and apply.
Description
Technical field
The invention belongs to medical wound dressing and preparation field thereof, particularly relate to one and be applicable to burn and scald, mechanicalness
Antibacterial heal-promoting aerogel dressing of wound, operative incision and chronic wound protection and treatment and preparation method thereof.
Background technology
Skin is the largest organ of human body, is to maintain homoiostasis and stop the natural cover for defense of microorganism invasion；So
And, large area is exposed to the feature in the external world so that skin is highly susceptible to the external injuries such as burn, mechanical injury.Due to
The pathogen such as staphylococcus aureus, escherichia coli is bred on wound, then be easily caused wound infection；The wound infected
Mouth is difficult to healing, easily causes body fluid and runs off and cause various complication.
It is referred to as the gauze class dressing of traditional dressing, is typically processed by Cotton Gossypii, lint and linen.This kind of dressing
Practicality is the strongest, power of influence is maximum, the application time is the longest, the most still occupies very big market share.Such dressing advantage
It is: have certain absorbability to make simple, low price, reusable；Shortcoming is: wound surface cannot be kept to moisten
The group that when causing wound healing delay, dressing fiber to easily cause foreign body reaction thus affect healing, change dressings, easy damaged is newborn
Knit, pathogen easily passes through the dressing being saturated, workload of changing dressings is big, and in gauze dressing, topical application antibiotic is led
The bacterial resistance caused more makes infective wound surface be difficult to heal.
1962, British scientist George doctor Winter invented " wet method therapy ", and he is in zoopery
Finding, under airtight moist environment, to be exposed to air drying wound surface more fast again for speed of wound healing ratio, thus establishes
New pattern compress is used to process the theoretical basis of wound surface.Since then, various new-type dressing based on this thought obtains extensively
Development, such as hydrocolloid dressing, aerogel dressing etc..Aerogel dressing has can substantially alleviating pain, absorption
Wound fluid, air permeable humidity retaining, and the wound tissue healed will not be destroyed during more change dressings, transparent can observe wound
The advantages such as mouth healing state；Meanwhile, have been demonstrated that use moisture-preserving dressing can be created one to wound local and imitate wound surface water
The wet condition of bubble physiological healing, makes wound re-epithelialization ability significantly improve, makes wound surface heal at faster speed.
Therefore, aerogel dressing obtains the most attention of various countries.
The main preparation methods of aerogel dressing has chemical method, freezing method and radiation method etc..Hydrogel prepared by chemical method
In would generally harmful small-molecule substance such as cross-linking agent needed for residual reaction process and initiator, affect it and use.Freezing
Method is a kind of very effective method preparing polyvinyl alcohol hydrogel reported the earliest by Peppas, and the method prepares
Hydrogel there is good springiness and the advantage such as mechanical strength is big, but this hydrogel is a kind of physical gel, in higher temperatures
Solution can be melted into when spending, and the swellbility of hydrogel is less and opaque, affect the sight to wound in therapeutic process
Examine.In document, the freezing thawing time of report is usually 8-24h, and manufacturing cycle is long, is unfavorable for the production of product.
Radiation method causes crosslinking to prepare aerogel dressing by high-energy radiation, and its process is not required to add any chemical cross-linking agent and draw
Sending out the harmful substances such as agent, product is pure, additionally, radiation can at room temperature be carried out, reaction condition is gentle, and can lead to
Crossing control radiation dose, close rate etc. and control properties of product, gel formation can be carried out with sterilizing simultaneously simultaneously.
It is published in " drug containing, the polyvinyl alcohol hydrogel dressing of chitosan and the preparation side thereof on June 13rd, 2007
Method " (CN1320931C) disclose the polyvinyl alcohol hydrogel dressing of a kind of drug containing, chitosan, this medical water-setting
Glue dressing can be used for treating various skin trauma and burn and scald, but have sorptivety liquid ability, there is plasticizer etc. and have
The shortcoming of pest matter residual；It is published in the " a kind of medical containing nanometer silver and carboxymethyl chitosan of on July 6th, 2011
Dressing and preparation method thereof " (CN102114265A) disclose a kind of containing nanometer silver and carboxymethyl chitosan medical dressing,
There is preferable antibiotic effect, but have and wound surface cannot be kept to moisten, cause wound healing to postpone；It is difficult to from wound surface
The shortcoming such as uncover；Be published on October 25th, 2006 " has the liquid wound promoting wound healing, antibacterial functions
Mouthful dressing " (CN100471528C) discloses a kind of has promotion wound healing, the liquid (gel) of antibacterial functions
Wound dressing, this medical dressing has anti-inflammatory analgesic, promotes effect of wound healing, but has absorption transudate energy
The shortcoming of power difference.
Summary of the invention
It is an object of the invention to provide one can absorb transudate, transparent, ventilative, waterproof, not with tissue adhesion,
Pliability is good, and be applicable to burn and scald, mechanicalness wound, operative incision and the chronic wound with anti-microbial property are protected
Antibacterial heal-promoting aerogel dressing with treatment.
For solving above-mentioned technical problem, the present invention takes techniques below scheme: a kind of antibacterial heal-promoting aerogel dressing, its
It is mainly composed of water miscible high molecular polymer, there is pseudoplastic functional polymer, antibacterial and water.Each mainly
The content of composition is: the water miscible high molecular polymer of 2%-12% in parts by weight, 0.1%-4% has vacation
The high molecular polymer of plasticity, the antibacterial of 0.01%-3% and the water of surplus.
Wherein, described water miscible high molecular polymer can be water-soluble high molecular polymer and synthesizing water-solubility height
One or more in Molecularly Imprinted Polymer, or be a combination of both.Described water-soluble high molecular polymer can be
The combination of one or more in alginic acid and derivant, hyaluronic acid and derivant thereof etc.；Described alginic acid derives
Thing is selected from sodium alginate, alginic acid magnesium, calcium alginate and potassium alginate etc.；Described derivatives of hyaluronic acids is selected from
Hyaluronic acid, hyaluronate sodium, calcium hyauronate and Curiosin etc..Described synthesizing water-solubility high molecular polymer
Can be in polyurethane, polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol oxide and sodium polyacrylate
The combination of one or more；The most more preferably high molecular polymer is polyvinyl alcohol and polyvinylpyrrolidone.
It is described that to have pseudoplastic natural polymers can be in agar powder, agarose, gelatin and carrageenan etc.
The combination of one or more.
Described antibacterial is the material that can effectively kill pathogenic bacterium, is selected from inorganic antiseptic, organic antibacterial agent and natural
One or more in antibacterial；Wherein: more preferably antibacterial is inorganic antiseptic or natural antibacterial agent；Described nothing
Machine antibacterial can be that silver ion and/or nanometer silver, described silver ion and/or nanometer silver are presented in ion, simple substance；
Described organic antibacterial can be water miscible quaternary ammonium salt antibacterial, as quaternary ammonium salt cationic polyacrylamide sterilizes
Agent, single quaternized pyridinium bactericide, biquaternary ammonium salts bactericides and/or compound quaternary ammonium salt antibacterial etc.；Described natural anti-
Microbial inoculum can be the extract of the natural animal-plant with bacteriostasis, as chitin, Chitosan-phospholipid complex, mustard,
Oleum Ricini and/or Wasabia japonic (Euterma Wasabi) etc., preferably chitin, Chitosan-phospholipid complex.Described Chitosan-phospholipid complex is
Small-molecular-weight chitosan (Mr:2 ten thousand) or macromolecule chitosan (Mr:200 ten thousand) and small-molecular-weight chitosan (Mr:
20000) share.
Another object of the present invention is to provide a kind of method preparing above-mentioned antibacterial heal-promoting aerogel dressing.
The method of described antibacterial heal-promoting aerogel dressing, comprises the following steps:
1) each component is weighed by formula；
2) by high molecular weight water soluble polymer with to have pseudoplastic high molecular polymer soluble in water, more than 90 DEG C
In water-bath, backflow forms homogeneous solution A, then antibacterial is soluble in water, and stirring forms uniform solution B, finally by A,
Two kinds of solution mixing of B, complement to gross weight with water, are stirred into uniform solution；
3) by step 2) in uniform solution carry out defoaming treatment after, pour in shaping dies, be cooled into pseudoplastic behavior
Solid；
4) the pseudoplastic behavior solid in step 3) is at room temperature carried out cross-linking radiation and sterilizing, radiation mode can be 60Co γ-
Ray or high-power electron beam ray, exposure time is 10-40min, and irradiation dose is 10K-70K.
Wherein, the defoaming treatment mode in described step 3) is for standing froth breaking, ultrasonic froth breaking or froth in vacuum.
The present invention is with such scheme, it is provided that one can absorb transudate, transparent, ventilative, waterproof, not viscous with tissue
Even, pliability good, and there is anti-microbial property, it is adaptable to burn and scald, mechanicalness wound, operative incision and chronic wound
Antibacterial heal-promoting aerogel dressing of face protection and treatment and preparation method thereof.This dressing is mainly composed of water miscible high score
Sub-polymer, there is pseudoplastic functional polymer, antibacterial and water, through series of process, it molten is integrated, molten
Liquid is poured into a mould in a mold, obtains through irradiation sterilization after solidification.Wound healing test, In vitro Bactericidal Experiments test result show
Showing that the present invention can effectively facilitate wound healing, and have preferable bacteriostatic activity to various bacteria, bacteriostasis rate reaches 70
More than %.It is in place of the actively progress of the present invention:
(1) this aerogel dressing is synchronously completed with sterilizing by radiation mode crosslinking, and preparation method is simple, significantly contracts
Short manufacturing cycle, and products pure, the gelatinous transparent degree of gained is high, swellbility is big, intensity is high.
(2) present invention choose agar powder, agarose, gelatin, carrageenan etc. have pseudoplastic natural polymer gather
One or more in compound, make sample at room temperature precuring, before forming false gel, beneficially irradiation process
Packaging and transport.
(3) hydrogel in the present invention can add one or more in inorganic antiseptic or natural antibacterial agent, can
Effectively to suppress the antibacterial of wound surface to infect, gram positive bacteria and negative bacterium are had good inhibiting effect, is difficult to
Produce drug resistance, promote cell regeneration, accelerate wound repair.
(4) hydrogel in the present invention has irritating solvent and the additive such as wetting agent, plasticizer without other,
Avoid such material toxic and side effects to skin, improve its biocompatibility.
In sum, the antibacterial heal-promoting aerogel dressing of the present invention is substantially better than existing aerogel dressing, has antibacterial
Evident in efficacy, transparent, water content is high, preparation method is simple, products pure, nontoxic, non-stimulated, biofacies
The advantages such as capacitive is good, suit large area to popularize and apply.
Below in conjunction with specific embodiment, the present invention is described in further details.
Detailed description of the invention
The invention provides a kind of antibacterial heal-promoting aerogel dressing, its be mainly composed of water miscible high molecular polymer,
There is pseudoplastic functional polymer, antibacterial and water.
Specifically, the content of the described each main component of antibacterial heal-promoting aerogel dressing is: 2%-12 in parts by weight
The high molecular weight water soluble polymer of %, 0.1%-4% has pseudoplastic high molecular polymer, and 0.01%-3%'s is anti-
Microbial inoculum and the water of surplus.
Water miscible high molecular polymer
In the present invention, water miscible high molecular polymer can be the one or several in high molecular polymer that is natural and that synthesize
Kind, or be a combination of both, during combination, ratio does not limit.
Water-soluble high molecular polymer can be in alginic acid and derivant, hyaluronic acid and derivant thereof etc.
Kind or several combinations, during combination, ratio does not limit；Described alginic acid derivative is selected from sodium alginate, alginic acid
Magnesium, calcium alginate and potassium alginate etc.；Described hyaluronic acid and derivant thereof be selected from hyaluronic acid, hyaluronate sodium,
Calcium hyauronate and Curiosin etc..Water-soluble high molecular polymer has biocompatibility and the biology of uniqueness
Activity, can be as the effective ingredient of aerogel dressing.When radiation method prepares medical hydrogel dressings, add certain proportion
Water-soluble high molecular polymer, the biocompatibility of hydrogel can be improved: meanwhile, water-soluble natural high score
Sub-polymer can be filled in gel network space after degrading under actinism, plays the work improving gel strength
With.
Synthesizing water-solubility high molecular polymer can be polyurethane, polyacrylamide, polyvinyl alcohol, polyvinylpyrrolidone,
The combination of one or more in polyethylene glycol oxide and sodium polyacrylate, during combination, ratio does not limit, the most more preferably
For polyvinyl alcohol and polyvinylpyrrolidone.The high molecular weight water soluble polymer of synthesis is because of its good bio-compatible
Property, mechanical performance and safety, and be widely used in medical industry.If the hydrogel being produced from is at eye
Being widely used in terms of section, wound dressing and artificial joint, have uniqueness strong adherence, pliability,
Flatness, oil resistivity, solvent resistance, protecting colloid, wearability and specially treated there is resistance to water etc.
Advantage.
There is pseudoplastic natural polymers
In the present invention, having pseudoplastic natural polymers can be agar powder, agarose, gelatin and carrageenan
The combination of one or more in Deng, during combination, ratio does not limit.This base polymer have dissolve in hot water formed
Solution, then forms the character of false solid, sample plays the effect of pre-solid, it is simple to carry out next step after cooling
Operation.
Antibacterial
In the present invention, antibacterial is the material that can effectively kill pathogenic bacterium, is selected from inorganic antiseptic, organic antibacterial agent
With one or more in natural antibacterial agent, during combination, ratio does not limit, and the most more preferably antibacterial is inorganic anti-
Microbial inoculum or natural antibacterial agent.
Inorganic antiseptic can be that silver ion and/or nanometer silver, described silver ion and/or nanometer silver are with ion, the shape of simple substance
Formula exists；
Organic antibacterial can be water miscible quaternary ammonium salt antibacterial, as quaternary ammonium salt cationic polyacrylamide sterilizes
Agent, single quaternized pyridinium bactericide, biquaternary ammonium salts bactericides and/or compound quaternary ammonium salt antibacterial etc.；
Natural antibacterial agent can be the extract of the natural animal-plant with bacteriostasis, such as chitin, chitosan and spread out
Biology, mustard, Oleum Ricini and/or Wasabia japonic (Euterma Wasabi) etc., preferably chitin, Chitosan-phospholipid complex.Wherein:
Chitin is to be formed by connecting with B-1,4 glycosidic bond forms by N-acetyl group-2-amino-2-deoxy-D-Glucose
Polysaccharide, chitosan is the product of the deacetylation of chitin.Chitin or chitosan especially small-molecular-weight chitosan has
There is significant bacteriostasis, skin bacterium such as staphylococcus epidermidis that general human epidermal is existed, cause burns
Bacillus pyocyaneus, staphylococcus aureus and streptococcus pyogenes etc. that people infects all have obvious inhibition.Meanwhile, shell
Polysaccharide can promote the regeneration of epithelial cell, accelerates the speed of wound healing, improves wound healing quality.Macromolecule
Chitosan can produce oligosaccharide, oligosaccharide, even monosaccharide with biodegradation, and then play its acceleration cell proliferation and add
The function of strong tissue remodeling.Meaningfully: it is good that macromolecule chitosan has film strength, small-molecular-weight chitosan
Having biological activity high, the feature of good water-retaining property, the present invention share macromolecule chitosan and small-molecular-weight chitosan
Respective advantage can be given full play to, the medical dressing that processability is excellent.
In the present invention, described water is purified water (clean deionized water or distilled water).
It is a further object to provide a kind of method preparing above-mentioned antibacterial heal-promoting aerogel dressing, specifically can wrap
Include following steps:
1) each component is weighed by formula；
2) by high molecular weight water soluble polymer with to have pseudoplastic high molecular polymer soluble in water, more than 90 DEG C
In water-bath, backflow forms homogeneous solution A, then antibacterial is soluble in water, and stirring forms uniform solution B, finally by A,
Two kinds of solution mixing of B, complement to gross weight with water, are stirred into uniform solution；
3) by step 2) in uniform solution carry out defoaming treatment after, pour in shaping dies, be cooled into pseudoplastic behavior
Solid；
4) the pseudoplastic behavior solid in step 3) at room temperature being carried out cross-linking radiation and sterilizing, radiation mode can be60Coγ-
Ray or high-power electron beam ray, exposure time is 10-40min, and irradiation dose is 10K-70K.
In above-mentioned preparation method, the defoaming treatment mode in described step 3) can be stand froth breaking, ultrasonic froth breaking or
Froth in vacuum.
Embodiment is implemented under premised on technical solution of the present invention, gives detailed embodiment and concrete
Operating process, embodiment will assist in and understands the present invention, but protection scope of the present invention is not limited to following embodiment.
In following embodiment, method therefor is conventional method if no special instructions.
Embodiment 1-10, prepare antibacterial heal-promoting aerogel dressing
The formula of embodiment of the present invention 1-10 antibacterial heal-promoting aerogel dressing and comparative example is as shown in table 1-2
Table 1 embodiment 1-5 antibacterial heal-promoting aerogel dressing and the formula of comparative example 1
(grams of each component in every 1000g antibacterial heal-promoting hydrogel)
Table 2 embodiment 6-10 antibacterial heal-promoting aerogel dressing and the formula of comparative example 2
(grams of each component in every 1000g antibacterial heal-promoting hydrogel)
Test one, particular product performance parameters detection
The performance parameter of the aerogel dressing preparing embodiment 1-10 detects, and the product of embodiment 1-10 meets
Claimed below:
1, character: for faint yellow or yellow transparent gel.
2, water absorption rate: the sample of Example 1-10 is each a little, prepare to weigh (W0), purified water is soaked 24h
After, taking-up filter paper dries surface moisture, correct amount (Wt), the part (W of hydrogel weightening finisht-W0) account for water-setting
Glue original weight (W0) percentage ratio, i.e. water absorption rate.The sample water absorption rate of embodiment 1-10 is all higher than 200%.
3, the own bacteria-measuring of product: method is carried out by GB/T14233.2-2005 pertinent regulations.Measurement result shows
Product itself is aseptic.
4, skin irritation index (PII) measures: the method specified by GB/T16886.10-2005 is carried out, it is desirable to acute
Contacting 24 hours, index is no more than 0.5.Measurement result shows that product meets the requirements.
5, sensitization of skin reaction assay: carry out by the closed sensitization test (STT) method of GB/T16886.10-2005 regulation,
All react without sensitization of skin.Measurement result shows that product does not cause sensitization of skin to react.
Test two, wound healing test
In order to verify the use effectiveness of subject hydrogel dressing, choose embodiment, comparative example is carried out with listing sample
Wound healing controlled trial.Concrete test method is as follows:
Experimental animal selects the New Zealand white rabbit of 1.8-2.5Kg, and point of observation is respectively 3d, 5d, 10d, 15d, every time
13 animals of phase point.White rabbit back after the cropping of 24h-72h back, is done depilation with depilatory cream and is processed before test.With
The pentobarbital sodium of 2.0%, is anaesthetized white rabbit by 1mL/Kg auricular vein, scalds 10s with 80 DEG C of hot water, white rabbit
Back causes to scald for I degree to light degree Ⅱ, each side at 2, is spaced more than 2cm.To implement respectively after scalding 1d
The antibacterial heal-promoting aerogel dressing of example 1-embodiment 10 gained scalds position as experimental group at four, every white rabbit back
1-experimental group 10；By the antibacterial heal-promoting aerogel dressing of comparative example 1 and comparative example 2 gained as a control group 1 and comparison
Group 2；To list the cold peaceful health of sample (domestic a kind of similar products) flap coverage, as a control group 3；Dry gauze is made
For matched group 4, calculate the healing rate of wound surface in each sampling time point.
The computational methods of Wound healing rate are as follows: first traced on onionskin by wound surface, then as template, by matter
The uniform hard paper in ground is cut into onesize, then weighs with scale, is indirectly indicative wound surface face with the quality of hard paper
Long-pending size.It is calculated as follows Wound healing rate: Wound healing rate (%)=(original wound surface area-do not heal wound surface
Area)/original wound surface area.Observe wound healing situation, determine healing time according to wound healing situation.
Result of the test is as shown in table 3, and from upper table, the result of the average healing rate of wound surface draws: test group 1-10 is to wound surface
The good effect of healing is better than matched group 1-3, compares with matched group 4, then can be seen that the aerogel dressing of the present invention
Than gauze, wound surface had more positive promoting healing effect.
Table 3 wound healing result of the test
Test three, product bacteriostatic test
With reference to GB/T15979-2002 Disposable Sanitary Accessory sanitary standard appendix C product bactericidal property, antibacterial
Regulation in performance and stability test method, aerogel dressing prepared by embodiment 1-10, comparative example 1-2 and on
The cold peaceful health of city's sample (negative control) has carried out extracorporeal bacteria inhibitor test.Test method is: preparation concentration is 104-105cfu/g
Bacteria suspension (staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, Candida albicans).Take 0.1mL's
Bacteria suspension is uniformly coated on and acts on 20min in coupons (2.0cm × 3.0cm) and comparison print (2.0cm × 3.0cm)
After, print is put in PBS solution, fully mix, do suitably dilution, 2-3 dilution factor.Take 0.5mL to be placed in
In sterilized petri dishes, with nutrient agar (staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa) or change
Fine horse fourth agar culture medium (Candida albicans) 30mL pours into, and rotates plate, fully mixes, put 37 DEG C ± 2 DEG C
24h cultivated by incubator (staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa) or 25 DEG C ± 2 DEG C incubators are (white
Color candidiasis) cultivate 72h, observed result.As bacteriostasis rate >=50%-90%, product has bacteriostasis, bacteriostasis rate >=90
%, product has stronger bacteriostasis.
Result of the test is as shown in table 4, it can be seen that the aerogel dressing of embodiment of the present invention 1-10 has preferably
Bacteriostatic activity, is better than comparative example 1(without the matched group with pseudoplastic natural polymers) and negative
Comparison (comparative example 2-is without matched group and the Leng Ningkang with pseudoplastic natural polymers and antibacterial).
Table 4 bacteriostatic test result
In addition, it should be noted that embodiment listed above and comparative example are only the parts of the present invention, but this
Bright it is not limited thereto, it is also possible to more deform.Therefore, those of ordinary skill in the art can be from the present invention
Open part directly derives or other available deformation of association, is accordingly to be regarded as the protection content of the present invention.
Claims (3)
1. an antibacterial heal-promoting aerogel dressing, its be mainly composed of high molecular weight water soluble polymer, have pseudoplastic
High molecular polymer, antibacterial and water, the content of each main component is: in parts by weight 8% polyvinyl alcohol, 2%
Polyethylene glycol oxide, the sodium alginate of 0.5%, the agarose of 1%, 0.5% Mr=2 ten thousand small-molecular-weight chitosan,
The macromolecule chitosan of the Mr=200 ten thousand of 0.5% and the water of surplus；Described high molecular weight water soluble polymer is polyethylene
Alcohol, polyethylene glycol oxide and sodium alginate, described in have pseudoplastic high molecular polymer be agarose, described antibacterial
For described small-molecular-weight chitosan and described macromolecule chitosan.
2. prepare a method for antibacterial heal-promoting aerogel dressing described in claim 1, comprise the following steps:
1) each component is weighed by formula；
2) by high molecular weight water soluble polymer with to have pseudoplastic high molecular polymer soluble in water, more than 90 DEG C
In water-bath, backflow forms homogeneous solution A, then antibacterial is soluble in water, and stirring forms uniform solution B, finally by A,
Two kinds of solution mixing of B, complement to gross weight with water, are stirred into uniform solution；
3) by step 2) in uniform solution carry out defoaming treatment after, pour in shaping dies, be cooled into pseudoplastic behavior
Solid；
4) to step 3) in pseudoplastic behavior solid at room temperature carry out cross-linking radiation and sterilizing, radiation mode is60Coγ-
Ray or high-power electron beam ray, exposure time is 10-40min, and irradiation dose is 10K-70K.
Preparation method the most according to claim 2, it is characterised in that: described step 3) in defoaming treatment side
Formula is for standing froth breaking, ultrasonic froth breaking or froth in vacuum.
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