CN107789518A - A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy - Google Patents

A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy Download PDF

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Publication number
CN107789518A
CN107789518A CN201711004496.XA CN201711004496A CN107789518A CN 107789518 A CN107789518 A CN 107789518A CN 201711004496 A CN201711004496 A CN 201711004496A CN 107789518 A CN107789518 A CN 107789518A
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parts
oral
nursing liquid
extract
prophylactic chemotherapy
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林振
顾志强
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
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Abstract

A kind of oral nursing liquid of oral mucositis caused by the present invention proposes Prophylactic chemotherapy, the oral nursing liquid raw material of oral mucositis caused by the Prophylactic chemotherapy include following components by weight：50 80 parts of pure water,6 10 parts of serissa serissoides,58 parts of the fruit of glossy privet,8 15 parts of wight fig leaf,6 10 parts of the dried rhizome of rehmannia,6 10 parts of radix scrophulariae,8 15 parts of the tuber of dwarf lilyturf,6 10 parts of the root of straight ladybell,1.0 2.0 parts of flavoring essence,The wind part of sweetener 2.0 3.0,58 parts of watermelon creme,7 10 parts of Dobell's solution,Middle 10 15 parts of liquid medicine forms for 0.1 0.8 parts with antiseptic,Dobell's solution is added in oral nursing liquid can effectively kill mould and bacterium,Prevent oral cavity from producing bacterium with this,The generation of bacterium can effectively be suppressed by antiseptic,So that prevent that oral mucositis effect is more preferable,The oral mucosa of patient can be protected by middle liquid medicine and watermelon creme,By sweetener and flavoring essence can oral nursing liquid taste it is more preferable,More crowds are adapted to this.

Description

A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy
Technical field
The present invention relates to oral nursing liquid technical field, the oral cavity shield of oral mucositis caused by specially a kind of Prophylactic chemotherapy Manage liquid.
Background technology
Portacaval mucositis refers to the inflammatory and exedens reaction in oral cavity, it be Chemotherapy in Malignant Carcinoma Patients it is relatively conventional and One of serious complication, conventional chemotherapy patient's stomatitis incidence are up to 40%, child patient, head and neck neoplasm and amalgamation The incidence for the treatment of person's stomatitis is higher.Its cardinal symptom is local pain and ageusia, especially with feed, speak and run into it is cold, Pain is more obvious after heat, acid, sweet tea etc. stimulate.It directly affects the feed of patient, and very big pain is brought to patient.Meanwhile Can also therefore and delay treatment, be forced reduce chemotherapeutics dosage, bring detrimental effect to prognosis.Serious oral mucosa The principal element of inflammation and lethal infection, according to relevant document report, its septicemia of 64% patients undergoing chemotherapy is by oral mucosa Caused by inflammation.Prevent the generation of portacaval mucositis and treat portacaval mucositis in time, to smoothly completing chemotherapy, reduce complication, protect Hinder chemotherapy success and improve patient quality of life it is significant, but it is existing up to the present, for chemotherapy stomatitis The method of prevention is mainly：Containing 0.8% allopurinol solution is gargled, (compound method is 2 grams of grind into powder+physiology of Allopurinol Tablets Salt solution 250ml)；Containing gargle method for 3 times/d, 20ml/ time, containing gargling 3~5min, be after three postprandial cold boiling waters are gargled containing the time is gargled, To end of chemotherapy since chemotherapy.This method is disadvantageous in that：Total effective rate is relatively low, probably maintains 60% or so.
The content of the invention
The technical problem to be solved in the present invention is to overcome the defects of existing, there is provided oral mucositis caused by a kind of Prophylactic chemotherapy Oral nursing liquid, effectively can solve the problems, such as in background technology.
To achieve the above object, the present invention proposes：A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, this is pre- The oral nursing liquid raw material of oral mucositis caused by anti-chemotherapy includes following components by weight：Pure water 50-80 parts, serissa serissoides 6-10 parts, fruit of glossy privet 5-8 parts, wight fig leaf 8-15 parts, dried rhizome of rehmannia 6-10 parts, radix scrophulariae 6-10 parts, tuber of dwarf lilyturf 8-15 part, the root of straight ladybell 6-10 parts, Flavoring essence 1.0-2.0 parts, sweetener 2.0-3.0 wind part, watermelon creme 5-8 parts, Dobell's solution 7-10 parts, middle liquid medicine 10- 15 parts and antiseptic 0.1-0.8 parts composition.
As a preferred technical solution of the present invention：The flavoring essence is that had by carrier, solvent, additive, carrier The materials such as sucrose, dextrin, gum arabic are formed, and carrier, additive and solvent are added in agitator, make carrier and addition Agent is dissolved into solvent.
As a preferred technical solution of the present invention：The sweetener is by sucrose, xylitol, fructose and glucose group Weight ratio into, the sucrose, xylitol, fructose and glucose is 1：2：2：3, sucrose, xylitol, fructose and glucose are added In hot pot, dissolved by heating and mixed by sucrose, xylitol, fructose and glucose, then dried, then by the sweetener after drying It is ground and is made by grinder.
As a preferred technical solution of the present invention：The watermelon creme is by water melon frost, borax, scutellaria, the coptis, Huang Cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and menthol composition.
As a preferred technical solution of the present invention：The Dobell's solution is by borax, sodium acid carbonate, liquefied phenol, sweet Oil and water being sufficiently stirred by mixer, make borax, sodium acid carbonate, liquefied phenol, liquefied phenol and glycerine be completely dissolved in water.
As a preferred technical solution of the present invention：The middle liquid medicine is by Honegsukle flower P.E, Radix Scrophulariae extract, henon bamboo Leaf extract, green-tea extract and Andrographis Paniculata are boiled by heating and mixing is produced and formed.
As a preferred technical solution of the present invention：The antiseptic is by such as crust extract, mustard extract, castor Sesame oil extract and horseradish extract composition.
Compared with prior art, the beneficial effects of the invention are as follows：Dobell's solution is added in oral nursing liquid to be had The kill mould of effect and bacterium, prevent oral cavity from producing bacterium with this, can effectively suppress the generation of bacterium by antiseptic, make It must prevent that oral mucositis effect is more preferable, the oral mucosa of patient can be protected by middle liquid medicine and watermelon creme, be led to Crossing sweetener and flavoring essence can make it that the taste of oral nursing liquid is more preferable, and more crowds are adapted to this.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all Belong to the scope of protection of the invention.
The present invention provides following technical scheme：
Embodiment one：
A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, the oral cavity of oral mucositis caused by the Prophylactic chemotherapy Conditioning liquid raw material includes following components by weight：50 parts of pure water, 6 parts of serissa serissoides, 5 parts of the fruit of glossy privet, 8 parts of wight fig leaf, the dried rhizome of rehmannia 6 Part, 6 parts of radix scrophulariae, 8 parts of the tuber of dwarf lilyturf, 6 parts of the root of straight ladybell, 1.0 parts of flavoring essence, the wind part of sweetener 2.0,5 parts of watermelon creme, Dobell's solution 0.1 part of 7 parts, 10 parts of middle liquid medicine and antiseptic composition, flavoring essence is by carrier, solvent, additive, and carrier has sucrose, paste The materials such as essence, gum arabic are formed, and carrier, additive and solvent are added in agitator, dissolve carrier and additive Into solvent, sweetener is the weight into, sucrose, xylitol, fructose and glucose by sucrose, xylitol, fructose and glucose group Amount is than being 1：2：2：3, by sucrose, xylitol, fructose and glucose heating kettle, pass through sucrose, xylitol, fructose and glucose Mixing is dissolved by heating, then is dried, then the sweetener after drying is ground by grinder and is made, watermelon creme is by west Melon frost, borax, scutellaria, the coptis, golden cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and menthol composition, a shellfish Er Shi liquid is sufficiently stirred by borax, sodium acid carbonate, liquefied phenol, G ＆ W by mixer, makes borax, sodium acid carbonate, liquid Change phenol, liquefied phenol and glycerine are completely dissolved in water, middle liquid medicine by Honegsukle flower P.E, Radix Scrophulariae extract, Herba Lophatheri extract, Green-tea extract and Andrographis Paniculata are boiled by heating and mixing is produced and formed, and antiseptic is by such as crust extract, mustard Last extract, Caster Oil Extract and horseradish extract composition.
The present invention selects oral mucositis patient totally 90 caused by being diagnosed as Prophylactic chemotherapy, choosing to verify therapeutic effect With the oral nursing liquid of the present embodiment 1, gargle 2-3 times daily, after treating 2-4 days, obtain following treatment results：
After 2-4 days, wherein the oral mucositis of 81 patients disappears, 8 patient's oral mucositis are effectively alleviated, only The state of an illness of 1 patient is without significant change, cure rate 90%, total effective rate 97.78%.
Embodiment two：
A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, the oral cavity of oral mucositis caused by the Prophylactic chemotherapy Conditioning liquid raw material includes following components by weight：60 parts of pure water, 8 parts of serissa serissoides, 6 parts of the fruit of glossy privet, 10 parts of wight fig leaf, the dried rhizome of rehmannia 8 parts, 8 parts of radix scrophulariae, 10 parts of the tuber of dwarf lilyturf, 8 parts of the root of straight ladybell, 1.3 parts of flavoring essence, the wind part of sweetener 2.3, watermelon creme 6 part, piece Bel 8 parts of family name's liquid, 12 parts of middle liquid medicine and 0.4 part of antiseptic composition, flavoring essence be by carrier, solvent, additive, carrier have sucrose, The materials such as dextrin, gum arabic are formed, and carrier, additive and solvent are added in agitator, make carrier and additive molten For solution into solvent, sweetener is into, sucrose, xylitol, fructose and glucose by sucrose, xylitol, fructose and glucose group Weight ratio is 1：2：2：3, by sucrose, xylitol, fructose and glucose heating kettle, pass through sucrose, xylitol, fructose and grape Sugar dissolves by heating mixing, then is dried, then the sweetener after drying is ground by grinder and is made, watermelon creme by Water melon frost, borax, scutellaria, the coptis, golden cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and menthol composition, piece Bei Ershi liquid is sufficiently stirred by borax, sodium acid carbonate, liquefied phenol, G ＆ W by mixer, make borax, sodium acid carbonate, Liquefied phenol, liquefied phenol and glycerine are completely dissolved in water, and middle liquid medicine is extracted by Honegsukle flower P.E, Radix Scrophulariae extract, lophatherum gracile Thing, green-tea extract and Andrographis Paniculata are boiled and mixing is produced and formed by heating, antiseptic by such as crust extract, Mustard extract, Caster Oil Extract and horseradish extract composition.
The present invention selects oral mucositis patient totally 50 caused by being diagnosed as Prophylactic chemotherapy, choosing to verify therapeutic effect With the oral nursing liquid of the present embodiment 2, gargle 2-3 times daily, after treating 2-4 days, obtain following treatment results：
After 2-4 days, wherein the oral mucositis of 56 patients disappears, 4 patient's oral mucositis are effectively alleviated, controlled More rate is 92%.
Embodiment three：
A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, the oral cavity of oral mucositis caused by the Prophylactic chemotherapy Conditioning liquid raw material includes following components by weight：70 parts of pure water, 9 parts of serissa serissoides, 7 parts of the fruit of glossy privet, 12 parts of wight fig leaf, the dried rhizome of rehmannia 9 parts, 9 parts of radix scrophulariae, 12 parts of the tuber of dwarf lilyturf, 9 parts of the root of straight ladybell, 1.7 parts of flavoring essence, the wind part of sweetener 2.7, watermelon creme 7 part, piece Bel 9 parts of family name's liquid, 13 parts of middle liquid medicine and 0.6 part of antiseptic composition, flavoring essence be by carrier, solvent, additive, carrier have sucrose, The materials such as dextrin, gum arabic are formed, and carrier, additive and solvent are added in agitator, make carrier and additive molten For solution into solvent, sweetener is into, sucrose, xylitol, fructose and glucose by sucrose, xylitol, fructose and glucose group Weight ratio is 1：2：2：3, by sucrose, xylitol, fructose and glucose heating kettle, pass through sucrose, xylitol, fructose and grape Sugar dissolves by heating mixing, then is dried, then the sweetener after drying is ground by grinder and is made, watermelon creme by Water melon frost, borax, scutellaria, the coptis, golden cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and menthol composition, piece Bei Ershi liquid is sufficiently stirred by borax, sodium acid carbonate, liquefied phenol, G ＆ W by mixer, make borax, sodium acid carbonate, Liquefied phenol, liquefied phenol and glycerine are completely dissolved in water, and middle liquid medicine is extracted by Honegsukle flower P.E, Radix Scrophulariae extract, lophatherum gracile Thing, green-tea extract and Andrographis Paniculata are boiled and mixing is produced and formed by heating, antiseptic by such as crust extract, Mustard extract, Caster Oil Extract and horseradish extract composition.
The present invention is in order to verify therapeutic effect, oral mucositis patient totally 100 caused by selection is diagnosed as Prophylactic chemotherapy, From the oral nursing liquid of the present embodiment 3, gargle 2-3 times daily, after treating 2-4 days, obtain following treatment results：
After 2-4 days, wherein the oral mucositis of 96 patients disappears, 4 patient's oral mucositis are effectively alleviated, controlled More rate is 96%.
Example IV：
A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, the oral cavity of oral mucositis caused by the Prophylactic chemotherapy Conditioning liquid raw material includes following components by weight：80 parts of pure water, 10 parts of serissa serissoides, 8 parts of the fruit of glossy privet, 15 parts of wight fig leaf, life 10 parts of ground, 10 parts of radix scrophulariae, 15 parts of the tuber of dwarf lilyturf, 10 parts of the root of straight ladybell, 2.0 parts of flavoring essence, the wind part of sweetener 3.0, watermelon creme 8 part, piece 0.8 part of 10 parts of Bei Ershi liquid, 15 parts of middle liquid medicine and antiseptic composition, flavoring essence is that had by carrier, solvent, additive, carrier The materials such as sucrose, dextrin, gum arabic are formed, and carrier, additive and solvent are added in agitator, make carrier and addition Agent is dissolved into solvent, and sweetener is into sucrose, xylitol, fructose and grape by sucrose, xylitol, fructose and glucose group The weight ratio of sugar is 1：2：2：3, by sucrose, xylitol, fructose and glucose heating kettle, by sucrose, xylitol, fructose and Glucose dissolves by heating mixing, then is dried, then the sweetener after drying is ground by grinder and is made, water melon frost Agent is by water melon frost, borax, scutellaria, the coptis, golden cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and menthol group Into Dobell's solution is sufficiently stirred by borax, sodium acid carbonate, liquefied phenol, G ＆ W by mixer, makes borax, carbonic acid Hydrogen sodium, liquefied phenol, liquefied phenol and glycerine are completely dissolved in water, and middle liquid medicine is by Honegsukle flower P.E, Radix Scrophulariae extract, lophatherum gracile Extract, green-tea extract and Andrographis Paniculata are boiled by heating and mixing is produced and formed, and antiseptic is carried by such as chitin Take thing, mustard extract, Caster Oil Extract and horseradish extract composition.
The present invention is in order to verify therapeutic effect, oral mucositis patient totally 200 caused by selection is diagnosed as Prophylactic chemotherapy, From the oral nursing liquid of the present embodiment 3, gargle 2-3 times daily, after treating 2-4 days, obtain following treatment results：
After 2-4 days, wherein the oral mucositis of 200 patients disappears, cure rate 100%.
Benefit of the present invention：Dobell's solution is added in oral nursing liquid can effectively kill mould and bacterium, with this Prevent oral cavity from producing bacterium, can effectively suppress the generation of bacterium by antiseptic so that prevent oral mucositis effect more It is good, the oral mucosa of patient can be protected by middle liquid medicine and watermelon creme, can be with by sweetener and flavoring essence So that the taste of oral nursing liquid is more preferable, more crowds are adapted to this.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of changes, modification can be carried out to these embodiments, replace without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (7)

  1. A kind of 1. oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy, it is characterised in that：Oral cavity caused by the Prophylactic chemotherapy sticks The scorching oral nursing liquid raw material of film includes following components by weight：Pure water 50-80 parts, serissa serissoides 6-10 parts, fruit of glossy privet 5-8 Part, wight fig leaf 8-15 parts, dried rhizome of rehmannia 6-10 parts, radix scrophulariae 6-10 parts, tuber of dwarf lilyturf 8-15 part, the root of straight ladybell 6-10 parts, flavoring essence 1.0-2.0 Part, sweetener 2.0-3.0 wind part, watermelon creme 5-8 parts, Dobell's solution 7-10 parts, middle liquid medicine 10-15 parts and antiseptic 0.1- 0.8 part of composition.
  2. 2. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Flavoring essence is to be made up of carrier, solvent, additive, carrier materials such as sucrose, dextrin, gum arabics, by carrier, addition Agent and solvent are added in agitator, carrier and additive is dissolved into solvent.
  3. 3. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Sweetener is to be into the weight ratio of, the sucrose, xylitol, fructose and glucose by sucrose, xylitol, fructose and glucose group 1：2：2：3, by sucrose, xylitol, fructose and glucose heating kettle, heated by sucrose, xylitol, fructose and glucose molten Solution mixing, then dried, then the sweetener after drying is ground by grinder and is made.
  4. 4. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Watermelon creme is by water melon frost, borax, scutellaria, the coptis, golden cypress, subprostrate sophora, fritillaria thunbergii, blackberry lily, indigo naturalis, borneol, soapberry and thin Lotus brain forms.
  5. 5. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Dobell's solution is sufficiently stirred by borax, sodium acid carbonate, liquefied phenol, G ＆ W by mixer, makes borax, bicarbonate Sodium, liquefied phenol, liquefied phenol and glycerine are completely dissolved in water.
  6. 6. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Middle liquid medicine passes through heating by Honegsukle flower P.E, Radix Scrophulariae extract, Herba Lophatheri extract, green-tea extract and Andrographis Paniculata Boil and mixing is produced and formed.
  7. 7. the oral nursing liquid of oral mucositis caused by a kind of Prophylactic chemotherapy according to claim 1, it is characterised in that described Antiseptic is made up of such as crust extract, mustard extract, Caster Oil Extract and horseradish extract.
CN201711004496.XA 2017-10-25 2017-10-25 A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy Pending CN107789518A (en)

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