CN1457833A - Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method - Google Patents
Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method Download PDFInfo
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- CN1457833A CN1457833A CN 03122364 CN03122364A CN1457833A CN 1457833 A CN1457833 A CN 1457833A CN 03122364 CN03122364 CN 03122364 CN 03122364 A CN03122364 A CN 03122364A CN 1457833 A CN1457833 A CN 1457833A
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- borneolum syntheticum
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Abstract
The indications of the medicine composition includes swelling and pain throat, aphtha, gingival bleeding, white mouth, light burns and scalds, acute and chronic laryngopharyngitis, tonsillitis, stomatitis and stomatocace. The medicine composition is prepared with watermelon pericarp, borax, phellodendron bark, Chinese goldthread, tonkin sophora root and other nine kinds of Chinese medicinal materials. During the preparation, the quality of the medicine composition is controlled through measuring the content of berberine hydrochloride and qualitative thin layer chromatographic process.
Description
Technical field
The present invention relates to a kind of compositions, be used for the treatment of laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, thrush, infantile facial sore and mild burn bleed, acute and chronic pharyngitis, tonsillitis, stomatitis, oral ulcer belongs to pyretic toxicity and causes the patient with heat-clearing and toxic substances removing, reducing swelling and alleviating pain effect.
Background technology
Throat and oral cavity diseases belongs to traditional Chinese medical science categories such as " tonsillitis, sore throat, aphonia due to throat disease ", be subordinate to ability to speak, larynx section, diseases such as the said acute and chronic pharyngitis of modern medicine, acute tonsillitis, oral ulcer, stomatitis, gingival swelling and pain, pathogeny Chinese medicine is thought " all diseases of throat all belong to fire ", mainly be body diseases caused by exogenous pathogenic factor pyretic toxicity and cause on the pathogenic fire scorchingly, or cause exopathogen because oral cavity and throat is unclean and invade.Moreover be exactly that plain body loses void, and cause hyperactivity of deficient fire.Modern medicine study thinks that the scorching card of oral cavity and throat disease mainly is an infected by microbes such as antibacterial, virus and causing, or body immunity is low, and antibacterial, virus are in the pathogenic microorganism growth imbalance of oral cavity and throat and cause infection.Also have due to the mechanical damage simultaneously, or excessively take place with throat.This disease can repeatedly take place, and can repeatedly take place.
The tradition Chinese medicine has much the commentary treatise of oral cavity throat disease, has also put down in writing many prescriptions, and as Yangyin Qingfei Tang, BINGPENG SAN etc., these prescriptions are to adopt according to concrete symptom, are the important component parts of Chinese medicine content.Ancient Chinese medicine medicine or Chinese medicine among the people are fully being summed up, excavating or utilized to the modern Chinese medicine theory also.Just introduce the many proved recipes of control oral cavity and throat diseases, typical prescription as Chinese medicine institution of higher learning teaching material " traditional Chinese medical science otolaryngology ", the control oral cavity and throat diseases is had directive function preferably.Some pharmaceutical factories and Chinese medicine research institution also release some medicines in recent years, as clear and rich lozenge of the four seasons, folk song buccal tablet etc.In view of market demand, we in conjunction with modern science and technology, develop a kind of Chinese medicine preparation for the treatment of the oral cavity and throat diseases determined curative effect according to traditional Chinese medicine theory.
Summary of the invention
The application's purpose just provides a kind of heat-clearing and toxic substances removing that has, the compositions of reducing swelling and alleviating pain effect is used for the treatment of laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, thrush, infantile facial sore and mild burn bleed, acute and chronic pharyngitis, tonsillitis, stomatitis, oral ulcer belongs to pyretic toxicity and causes the patient.Raw material is formed:
The application's medicine is made by watermelon crystal, Borax (forging), Cortex Phellodendri, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Rhizoma Belamcandae, Bulbus Fritillariae Uninbracteatae, Indigo Naturalis, Borneolum Syntheticum, Fructus Sapindi Mukouossi fruit (parch to black), Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Glycyrrhizae, Mentholum.The weight proportion of each raw material is:
Watermelon crystal 30-50, Borax(calcined) 15-28, Cortex Phellodendri 6-15, Rhizoma Coptidis 6-14, Radix Scutellariae 5-14, Bulbus Fritillariae Uninbracteatae 7-15, Radix Sophorae Tonkinensis 13-19, Rhizoma Belamcandae 6-13, Indigo Naturalis 10-16, Borneolum Syntheticum 15-19, Fructus Sapindi Mukouossi fruit (charcoal) 6-15, Radix Et Rhizoma Rhei 3-7, Radix Glycyrrhizae 7-14, Mentholum 6-12.
Preferred weight proportion is:
Watermelon crystal 40 Indigo Naturaliss 14 Radix Scutellariaes 11
Radix Glycyrrhizae 9.5 Cortex Phellodendris 12 carbonized fructus sapindi mukouossis 10
Borax(calcined) 20 Radix Sophorae Tonkinensiss 15 Rhizoma Coptidis 12.5
Bulbus Fritillariae Uninbracteatae 9 Rhizoma Belamcandae 8 Radix Et Rhizoma Rhei 5
Borneolum Syntheticum 15 Mentholums 8.5
The preferred Bulbus Fritillariae Thunbergii of Bulbus Fritillariae Uninbracteatae
The application's compositions can adopt the conventional method of galenic pharmacy to make regular dosage form, and as powder, capsule, tablet, concentrated pill, granule, oral liquid, syrup, drop pill, paster etc., preferred dosage form is a powder.
Method for making: above 14 flavors, except that Borneolum Syntheticum, Mentholum, all the other raw material powders are broken into fine powder; With Borneolum Syntheticum and Mentholum difference porphyrize, with above-mentioned fine powder and an amount of adjuvant facing-up, sieve, mixing, promptly.
Fine powder except that Borneolum Syntheticum, Mentholum should be sterilized under 80-120 degree centigrade environment before mixing, and takes conventional method to carry out drying.
Function with cure mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Be used for laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, thrush, infantile facial sore and mild burn bleed; Acute and chronic pharyngitis, tonsillitis, stomatitis, oral ulcer are seen above-mentioned patient.
The pharmacological action of GUILIN XIGUA SHUANG
We carry out pharmacological research to the GUILIN XIGUA SHUANG (powder) that makes by above method, and the result shows that GUILIN XIGUA SHUANG has stronger antibiotic, antiinflammatory and promotes all effects of ulcer healing.It has stronger antibacterial action and wider bactericidal range to adopt medicated powder directly to be coated with the method for spreading, medicated powder " abnormal smells from the patient " diffusion method, dish dilution method proof, and alpha streptococcus, group B streptococcus, staphylococcus aureus, Bacillus typhi, escherichia coli, Candida albicans are all had bactericidal action.To Mice Auricle Oleum Tiglii cause inflammation, rat Ovum Gallus domesticus album inflammation through outside be coated with, irritate stomach or intraperitoneal injection all presents stronger anti-inflammatory effect, the ip GUILIN XIGUA SHUANG increases the mouse skin capillary permeability significant antagonism.To the experimental therapy of oral ulcer due to the carbolic acid, the result shows and can shorten the ulcer healing time significantly.Cavia porcellus intradermal injection GUILIN XIGUA SHUANG has certain topical pain relief effect, and the persistent period can reach more than 90 minutes.
Influence (lung tissue hyporrhea) and powder to pulmonary after this drug spray suck, and it is relevant to stimulate air flue to cause cough, can recover gradually after the drug withdrawal, and filling stomach and lumbar injection GUILIN XIGUA SHUANG toxicity are little, and the internal organs microscopy is not seen significant change.
The brief summary of GUILIN XIGUA SHUANG clinical data
By first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, second Affiliated Hospital and three tame hospitals of the Guangxi People's Hospital of the Autonomous Region, relevant requirements by " provisions for new drugs approval " and " new Chinese medicine clinical research guideline ", this product has been carried out the clinical verification of 360 examples with the form of matched group, the result shows, this product is to acute pharyngitis, acute catarrhal tonsillitis, acute gingivitis and papillary gingivitis, the total effective rate of minor aphtha is respectively 91.1%, 91.1%, 90%, 92.2%, do not see that during clinical observation obvious adverse reaction and side effect take place.
In addition, this product is carried out clinical verification in Affiliated Hospital of Medical Colleges Of Guilin and second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, relevant requirements by " provisions for new drugs approval " and " new Chinese medicine clinical research guideline ", this product has been carried out the clinical verification of 100 examples, the result shows, this product is respectively 100% and 96% to the total effective rate of wind heat (attacking lung) card acute pharyngitis and minor aphtha, and is clinical safe and reliable, do not see obvious adverse reaction.
In sum, this product has been carried out the clinical verification of 460 examples altogether after listing, and the result shows that this product is at the treatment acute/chronic pharyngitis, tonsillitis, show definite curative effect on the aditus laryngis illness such as minor aphtha, and clinical safe in utilization, do not see obvious toxic-side effects and untoward reaction.
Specific embodiments
Embodiment 1 preparation GUILIN XIGUA SHUANGRaw material:
Watermelon crystal 199g Indigo Naturalis 64g Radix Scutellariae 40g
Radix Glycyrrhizae 45g Cortex Phellodendri 42g Fructus Sapindi Mukouossi fruit (charcoal) 33g
Borax (forging) 125g Radix Sophorae Tonkinensis 85g Rhizoma Coptidis 43g
Bulbus Fritillariae Thunbergii 42g Rhizoma Belamcandae 44g Radix Et Rhizoma Rhei 20g
Borneolum Syntheticum 86g Mentholum 32g
Make product 1000 restraint methods altogether:
1. get the raw material except that Borneolum Syntheticum, Mentholum, pulverize separately becomes fine powder, crosses 140～180 mesh sieves, and sterilization is 30 minutes under 80-120 degree centigrade environment, is dried to water content≤8%;
Borneolum Syntheticum, Mentholum respectively with an amount of above-mentioned fine powder and adjuvant facing-up, cross 140 mesh sieves;
3. each fine powder mixing gets product.
Claims (8)
1. a Chinese medicine composition for the treatment of oral cavity and throat diseases is characterized in that being made by following materials of weight proportions: watermelon crystal 30-50, Borax(calcined) 15-28, Cortex Phellodendri 6-15, Rhizoma Coptidis 6-14, Radix Scutellariae 5-14, Bulbus Fritillariae Uninbracteatae 7-15, Radix Sophorae Tonkinensis 13-19, Rhizoma Belamcandae 6-13, Indigo Naturalis 10-16, Borneolum Syntheticum 15-19, carbonized fructus sapindi mukouossi 6-15, Radix Et Rhizoma Rhei 3-7, Radix Glycyrrhizae 7-14, Mentholum 6-12.
2. compositions according to claim 1 is characterized in that the weight proportion of each raw material is:
Watermelon crystal 40 Indigo Naturaliss 14 Radix Scutellariaes 11
Radix Glycyrrhizae 9.5 Cortex Phellodendris 12 carbonized fructus sapindi mukouossis 10
Borax(calcined) 20 Radix Sophorae Tonkinensiss 15 Rhizoma Coptidis 12.5
Bulbus Fritillariae Uninbracteatae 9 Rhizoma Belamcandae 8 Radix Et Rhizoma Rhei 5
Borneolum Syntheticum 15 Mentholums 8.5
3. prepare claim 1 or 2 described method for compositions, it is characterized in that carrying out according to the following steps: get raw material, the raw material powder except that Borneolum Syntheticum, Mentholum is broken into fine powder; With Borneolum Syntheticum and Mentholum difference porphyrize, the appropriate amount of auxiliary materials facing-up with above-mentioned fine powder reaches or selects sieves, mixing, that is and, the fine powder except that Borneolum Syntheticum, Mentholum is sterilized under 80-120 ℃ environment before mixing, and takes conventional method to carry out drying.
4. claim 1 or 2 described Chinese medicine compositions is characterized in that the preferred Bulbus Fritillariae Thunbergii of wherein used Bulbus Fritillariae Uninbracteatae.
5. claim 1 or 2 described Chinese medicine compositions is characterized in that adopting the conventional method of galenic pharmacy to make regular dosage form.
6. compositions according to claim 5 is characterized in that dosage form is powder, capsule, tablet, concentrated pill, granule, oral liquid, syrup, drop pill or paster.
7. compositions according to claim 5 is characterized in that dosage form is a powder.
8. claim 1 or 2 described compositionss belong to the purposes in the morbific medicine of pyretic toxicity in preparation treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, thrush, infantile facial sore and mild burn bleed, acute and chronic pharyngitis, tonsillitis, stomatitis, oral ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03122364 CN1244361C (en) | 2003-04-29 | 2003-04-29 | Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03122364 CN1244361C (en) | 2003-04-29 | 2003-04-29 | Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method |
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| CN1457833A true CN1457833A (en) | 2003-11-26 |
| CN1244361C CN1244361C (en) | 2006-03-08 |
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| CN 03122364 Expired - Lifetime CN1244361C (en) | 2003-04-29 | 2003-04-29 | Medicinal composition for curing oral and throa diseases and its preparing method, use and quality control method |
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| CN1295504C (en) * | 2004-08-27 | 2007-01-17 | 广州中一药业有限公司 | Quality control method for nasopharynx tablet |
| CN1318069C (en) * | 2005-07-31 | 2007-05-30 | 刘荣常 | Shuanghuang Zhenbei powder medicine |
| CN100425986C (en) * | 2004-08-27 | 2008-10-15 | 广州中一药业有限公司 | Quality control method for Wushezhiyang pill |
| CN100443108C (en) * | 2004-03-29 | 2008-12-17 | 张兆春 | Plaster for treating pneumonia and tracheitis and its preparing method |
| CN101264225B (en) * | 2008-04-26 | 2010-10-20 | 聂兆刚 | Orally-administered decoction for treating ulcer in tongue base |
| CN101491614B (en) * | 2008-11-27 | 2011-04-20 | 北京宏泰康达医药科技有限公司 | Traditional Chinese medicine composition for treating mouth and tongue sore and stomatocace |
| CN101194950B (en) * | 2007-12-11 | 2011-05-04 | 徐东健 | Powder medicine medicament for treating children's stomatitis |
| CN102048849A (en) * | 2010-11-24 | 2011-05-11 | 荣成市新技术应用研究所 | Traditional Chinese medicine composition for treating aphtha |
| CN101396488B (en) * | 2008-10-29 | 2011-06-01 | 宗希阳 | Medicine for treating chronic faucitis |
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| CN102366489A (en) * | 2011-10-26 | 2012-03-07 | 文登市口腔医院 | Chinese traditional medicine for treating acute tonsillitis |
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2003
- 2003-04-29 CN CN 03122364 patent/CN1244361C/en not_active Expired - Lifetime
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