CN107744524A - A kind of bacteriostatic gel containing the tincture of iodine and preparation method thereof - Google Patents
A kind of bacteriostatic gel containing the tincture of iodine and preparation method thereof Download PDFInfo
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- CN107744524A CN107744524A CN201710923947.3A CN201710923947A CN107744524A CN 107744524 A CN107744524 A CN 107744524A CN 201710923947 A CN201710923947 A CN 201710923947A CN 107744524 A CN107744524 A CN 107744524A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a kind of bacteriostatic gel containing the tincture of iodine and its method processed, its composition to include following mass percent component：The tincture of iodine 0.5% 10%, macromolecule thickener 0.1% 3%, chitosan or chitin derivativ 0.1% 5%, zinc salt 0.05% 2%, alcohol 10% 75%, pure water 20% 80%.The present invention is by the way that the tincture of iodine and chitosan/chitin derivativ are complexed; make the axis part of the conveyor screw of iodine molecule insertion chitosan/chitin derivativ; form faint yellow or colourless transparent inclusion compound; make the iodine in system is more stable to be present in gel; the surface of a wound can be protected after smearing film forming; persistently play antibacterial/biocidal efficacies; play promotion Healing of the chitosan/chitin derivativ to the surface of a wound simultaneously; good healing environment is provided for the surface of a wound; and effectively reduce product excitant, corrosivity; xanthochromia is avoided, and without de- iodine after use.The present invention has stronger bacteriostasis to pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Candida albicans, can be applied to the antibacterial/antibacterial of bacterium, fungi.Situations such as can be additionally used in bite by mosquitos, pruitus, red swelling of the skin, whelk it is antibacterial.
Description
Technical field
The present invention relates to a kind of bacteriostatic agent and preparation method thereof, more particularly to a kind of bacteriostatic gel containing the tincture of iodine and its preparation
Method.
Background technology
The tincture of iodine is also known as the tincture of iodine, is widely known disinfection sanitizer, can efficiently kill the bacterium of skin infection, gemma,
The pathogenic bacteria such as protozoon, mould, fungi, virus, its mechanism of action for aoxidize its magma albumen movable group, and with protein
Amino with reference to and make its denaturation, zymoprotein is aoxidized and is inactivated.Directly act at sufferer, iodide ion can destroy cause rapidly
Germ, it is gradually reduced at sufferer, makes downright bad tissue loss, collagenous fibres cell propagation repairs skin.
The tincture of iodine has that excitant is strong, corrosivity is strong, needs alcohol take off iodine, unstable, and xanthochromia is ugly after smearing, easily
The shortcomings of being infected with clothing.
To improve drawbacks described above existing for iodine, scientific research personnel has done substantial amounts of research work.The 50's of 20th century, people
Investigated the chelated iodine of Iodophor-i.e., realize the bactericidal effect that can either retain iodine, can reduce again the excitant of iodine with it is rotten
Corrosion, utilization of the mankind to I is lifted to a new height again.
Specifically, chelated iodine be iodine is formed with complexing agents such as surfactants by way of complexing it is various indefinite
The complex compound of type, it is without fixed molecular formula and molecular weight.The chelated iodine of this type due to carrier, formula, technique difference,
The complexing degree difference, the physicochemical property presented, fungicidal effectiveness, security, stability etc. of various chelated iodines is also different.Mesh
Before, the Iodophor of domestic and foreign literature report has kind more than 100.Western developed country will be in the end of the year in last century 80, from numerous Iodophors
PVP-I (PVP-I) is filtered out, is widely used in hospital clinical, and has been included in the states such as the U.S., China, Britain, Japan
Pharmacopeia.PVP-I is to bacterial propagule（Such as staphylococcus aureus, Escherichia coli, streptococcus, Pseudomonas aeruginosa）, tuberculosis point
Branch bacillus, bacteriophage, bacterial spore, fungi, virus and protozoon have good killing action, and by environment and organic matter shadow
Sound is smaller, is skin, mucous membrane and the surgical operation disinfectant of domestic and international first choice at present.
Although PVP-I volatility compared with the tincture of iodine is small, good water solubility, excitant is relatively small is also easier to elute,
Still suffering from some shortcomings needs to improve, and if PVP-I is rufous liquid, can dye skin after smearing, be also easy to produce pigment and sink
Product；Although its excitant is light compared with the tincture of iodine, but still it can cause allergic reaction and the stimulation to skin, mucous membrane, outside for pregnant woman, wet nurse
Obvious absorption, local excitation and the burn feeling of iodine can be caused with baby；PVP-I, which has, acts on tissue dewatering, causes the surface of a wound
Dry, be unfavorable for wound healing；PVP-I illumination and it is heated when it is unstable, it is necessary to be kept in dark place；PVP-I still has one
Determine corrosivity, soaking metallic article for a long time can cause to corrode.
The content of the invention
In view of the above-mentioned problems, can continue to play antibacterial/bacteriostasis it is an object of the invention to provide one kind, effectively reduce
Excitant, coloration, faint yellow or water white transparency bacteriostatic gel containing the tincture of iodine are not produced to skin.
The gel of the present invention contains the tincture of iodine composition of broad-spectrum antibacterial, simultaneously chitosan/crust containing wound healing
Plain derivative composition, due to the good film forming of chitosan/chitin derivativ, slow release, one can be formed in the surface of a wound after smearing
Layer diaphragm, is sustained antibacterial/bactericidal active ingredient iodine, persistently plays antibacterial/biocidal efficacies, and can avoid regional iodine concentration's mistake
Height, iodine corrosivity is avoided, more preferable effect is can reach compared with other antibacterial more low-frequency access times of product, there is preferably safety
Property.Meanwhile the gel plays the performance of keeping humidity of chitosan/chitin derivativ, promotes cell growth and wound healing work(
Effect, provides good environment for wound repair, effectively facilitates wound healing.
It is a further object to provide the preparation method of the above-mentioned bacteriostatic gel containing the tincture of iodine.
The composition of the present invention includes the tincture of iodine, macromolecule thickener, chitosan/chitin derivativ, zinc salt, alcohol and water,
By the way that the tincture of iodine and chitosan/chitin derivativ are complexed, iodine acts on the hydroxyl of chitosan/chitin derivativ, makes iodine point
The axis part of the conveyor screw of the embedded chitosan/chitin derivativ of son, forms faint yellow or colourless transparent inclusion compound, makes body
What the iodine in system was more stablized is present in gel, can protect the surface of a wound after smearing film forming, persistently play antibacterial/biocidal efficacies, together
Promotion Healing of the Shi Fahui chitosans/chitin derivativ to the surface of a wound, good healing environment is provided for the surface of a wound, and have
Effect reduces product excitant, corrosivity, avoids xanthochromia, and without de- iodine after use.
Specific technical scheme of the invention is as follows：
A kind of bacteriostatic gel containing the tincture of iodine, including following mass percent component：Tincture of iodine 0.5%-10%, macromolecule thickener 0.1%-
3%, chitosan or chitin derivativ 0.1%-5%, zinc salt 0.05%-2%, alcohol 10%-75%, pure water 20%-80%.
The tincture of iodine is iodine, KI, alcohol, pure water are mixed with certain proportion, wherein the quality of iodine and KI
Than for（0.5-10）：1, the concentration of volume percent of alcohol is 10%-75%.
The macromolecule thickener is hydroxyethylmethylcellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl first
One or more in base cellulose, carboxymethyl hydroxyethyl cellulose, hydroxypropyl cellulose, carbomer or xanthans.
The chitosan or chitin derivativ are Carboxylation chitosan, benzoylation chitosan, cyanoethyl chitosan, hydroxyl
Propyl group chitosan, Hydroxypropyl chitosan, hydroxyethyl chitosan, ethoxyl chitin, carboxymethyl chitosan, carboxymethyl chitin,
Carboxyetbyl chitosan, carboxyethyl chitin, succinyl-chitosan, succinyl chitin, sulfonated chitosan, sulfonated crust
Element, the benzaldehyde Schiff 's base of chitosan, N- ethyl chitosans, N- succinylated chitosans, N- maleylations chitosan, N-
One or more in phthaloyl chitosan, N- Acetylated Chitosans.
The zinc salt is zinc lactate, zinc gluconate, zinc acetate, Firebrake ZB, amino-acid zinc, licorzinc, zinc citrate, boron
One or more in sour zinc, zinc chloride, zinc acetate, Firebrake ZB.
The preparation method of the present invention comprises the following steps：（1）Pure water, alcohol are added in reaction vessel, zinc salt is added and stirs
After mixing dissolving, macromolecule thickener is added, is heated to 30 DEG C ~ 45 DEG C, stirring at low speed 2-6 hours, 30 ~ 60min of high-speed stirred
Or 10 ~ 40min is emulsified at a high speed；（2）Chitosan or chitin derivativ are added, stirring at low speed 2-6 is small under the conditions of 30 DEG C ~ 45 DEG C
When, 10 ~ 40min of 30 ~ 60min of high-speed stirred or emulsification, standing 5-7 hours make its natural cooling be down to room temperature；（3）It is slowly added to
Tincture of iodine solution, 10 ~ 60min of high-speed stirred or emulsification, 30 ~ 60min of stirring at low speed, lucifuge, is sealed in stand in container and decolourizes, i.e.,
Obtain the bacteriostatic gel containing the tincture of iodine.
Faint yellow or water white transparency is made using the tincture of iodine and chitosan/chitin derivativ as principle active component in the present invention
Gel, the tincture of iodine are complexed with the composition in gel, become faint yellow or colorless transparent gel shape, and chitosan/chitin derives
It is film forming after smearing that thing, which has wound healing effect and good film forming, gel, not only protects wound isolation extraneous dirty
Dye, antibacterial/bacteriostasis is persistently played, formed with the microenvironment wound healing reparation beneficial to wound healing, is also solved
The problems such as tincture of iodine needs alcohol to take off iodine, burn into excitant high, xanthochromia, improve the security of product and both effectiveness.The present invention compares
In PVP-I, color is more shallow, near colorless clear gel, substantially increases the aesthetic measure that product uses, and the present invention
Layer protecting film can be formed in skin surface after smearing, antibacterial, promoting healing function are persistently played while the surface of a wound is protected, it is lower
The access times of frequency can reach more preferable effect, and excitant is lower safer.The present invention is to Escherichia coli, golden yellow Portugal
The pathogenic bacteria such as grape coccus, Candida albicans have stronger bacteriostasis, can be applied to the antibacterial/antibacterial of bacterium, fungi.And can
For the antibacterial of skin malaise symptoms caused by bacterium, fungi etc., mitigate skin tinea, prevent trauma surface infestation, promote the surface of a wound to be cured
Close.Situations such as can be additionally used in bite by mosquitos, pruitus, red swelling of the skin, whelk it is antibacterial.
Embodiment
Below by specific embodiment, the present invention will be described in detail, so that advantages and features of the invention can be easier to
It is readily appreciated by one skilled in the art, apparent is clearly defined so as to be made to protection scope of the present invention.
Embodiment 1：
Pure water 35L is measured in vacuum emulsifying machine, 95% alcohol 60L is added, stirring, adds the stirring of 0.1kg zinc gluconates, it is molten
Hydroxyethyl cellulose 0.5kg is added after solution, 35 DEG C~40 DEG C is heated to, stirring at low speed 3-5 hours, emulsifies 5-20min at a high speed, then
Add hydroxypropyl chitosan（Qingdao Honghai Biotechnology Co., Ltd., pH6~8, substitution value >=60%）3kg, 35 DEG C~40 DEG C are stirred
Mix 2-3 hours, emulsify 10-30min at a high speed, both is uniformly mixed.Standing 5-7 hours makes its natural cooling be down to room temperature, so
Tincture of iodine solution is added afterwards（The mass ratio of self-control tincture of iodine solution, iodine and KI is 2：1, the concentration of volume percent of alcohol is
60%）0.6L, 10min, stirring at low speed 30min-60min are emulsified at a high speed, load container interior sealing lucifuge and stand decolouring in 7 days or so,
Obtain tincture of iodine bacteriostatic gel A.
Embodiment 2：
Pure water 43L is measured in vacuum emulsifying machine, 95% alcohol 50L is added, stirring, the stirring of 0.2kg zinc acetates is added, after dissolving
Hydroxypropyl cellulose 1kg is added, 35 DEG C~40 DEG C is heated to, stirring at low speed 3-5 hours, emulsifies 5-20min at a high speed, add carboxylic
Methyl chitin（Qingdao Honghai Biotechnology Co., Ltd., pH6~8, substitution value >=80%）2kg, 35 DEG C~40 DEG C stirring 2-3
Hour, 10-30min is emulsified at a high speed, both is uniformly mixed.Standing 5-7 hours makes its natural cooling be down to room temperature, then adds
The tincture of iodine（The mass ratio of self-control tincture of iodine solution, iodine and KI is 4：1, the concentration of volume percent of alcohol is 50%）2L, it is newborn at a high speed
Change 15min, stirring at low speed 30min-60min, load container interior sealing lucifuge and stand decolouring in 15 days or so, obtain tincture of iodine bacteriostatic gel
B。
Embodiment 3：
Pure water 53L is measured in vacuum emulsification agent, 95% alcohol 40L is added, stirring, adds the stirring of 1kg zinc acetates, add after dissolving
Enter carboxymethyl hydroxyethyl cellulose 2kg, be heated to 35 DEG C~40 DEG C, stirring at low speed 3-5 hours, emulsify 5-20min at a high speed, then add
Enter sulfonated chitosan（Self-control, pH6~8, substitution value >=60%）2kg, 35 DEG C~40 DEG C stirring 2-3 hours, 10- is emulsified at a high speed
30min, both are made uniformly to mix.Standing 5-7 hours makes its natural cooling be down to room temperature, then adds the tincture of iodine（It is molten to make the tincture of iodine by oneself
The mass ratio of liquid, iodine and KI is 5：1, the concentration of volume percent of alcohol is 40%）5L, emulsifies at a high speed 20min, and low speed stirs
30min-60min is mixed, loads container interior sealing and stands decolouring in 20 days or so, obtain tincture of iodine bacteriostatic gel C.
Embodiment 4：Tincture of iodine bacteriostatic gel fungistatic effect
By GB 15979-2002《Disposable Sanitary Accessory sanitary standard》Appendix C stripping property resists（Suppression）Bacterium product is antibacterial
The tincture of iodine bacteriostatic gel A, B, C that method for testing performance is prepared to embodiment 1-3 carry out bacteriostasis property measure, as a result show that the tincture of iodine presses down
Bacterium gel A, B, C is respectively provided with stronger bacteriostasis to Escherichia coli, Staphylococcus aureus, Candida albicans.Concrete outcome is shown in
Table 1.
Fungistatic effect of the tincture of iodine bacteriostatic gel of table 1. to test organisms
Note：Negative control Sterile grows.
Embodiment 5：
Press《Disinfection technology standard》Disposable damaged skin stimulates in the sterile products toxicology test technical specifications of version 2.3 in 2002
Experiment, multiple intact skin irritant test, vaginal mucomembranous irritant test, Skin allergy test are prepared to embodiment 1-3
The tincture of iodine bacteriostatic gel A, B, C carry out excitant evaluation, as a result show, three kinds of tincture of iodine bacteriostatic gels are to damaged skin, intact skin
And vagina mucosa is non-stimulated, skin allergic reaction is had no, there is good security.
Embodiment 6：The promoting healing effect of tincture of iodine bacteriostatic gel
Using Wistar rats as experimental animal, big white mouse 40, male and female and half, body weight 250g ± 20g.4 groups of experiment point：It is poly-
Dimension ketone iodine control group, tincture of iodine bacteriostatic gel A groups, tincture of iodine bacteriostatic gel B groups, tincture of iodine bacteriostatic gel C groups, every group 10.Respectively with
30mg/kg body weight intraperitoneal injection 2%（Percent weight, similarly hereinafter）Yellow Jackets are anaesthetized, and big white mouse back is fixed on into hand upward
On art frame, back is shaved off to the hair of 1cm × 2cm areas with razor blade, made of the blade of sterilization at back unhairing position
The otch that 1.5cm is long, 1mm is deep.Each test group carries out lower column processing：（1）Control group smears covering control with Betagen Solution
The group rat surface of a wound；（2）Tincture of iodine bacteriostatic gel A rats in test groups smears tincture of iodine gel in incision and the surface of a wound is completely covered；（3）The tincture of iodine
Bacteriostatic gel B rats in test groups smears tincture of iodine gel in incision and the surface of a wound is completely covered；（4）Tincture of iodine bacteriostatic gel C test groups are big
Mouse smears tincture of iodine gel in incision and the surface of a wound is completely covered.Postoperative each group rat is wrapped up with sterile gauze, normal raising, daily
Dressing simultaneously observes Rat Wound Healing situation, to evaluate influence of the tincture of iodine bacteriostatic gel to Rat Wound Healing.As a result such as table 2.
The promoting healing result of the test of the tincture of iodine bacteriostatic gel of table 2
| Group | Animal groups（Only/group） | Average wound healing number of days |
| PVP-I control group | 10 | 9.5 my god |
| Tincture of iodine bacteriostatic gel A | 10 | 6 days |
| Tincture of iodine bacteriostatic gel B | 10 | 5.5 my god |
| Tincture of iodine bacteriostatic gel C | 10 | 5.5 my god |
Experiment results proved, the wound healing positive effect of tincture of iodine bacteriostatic gel are better than PVP-I.
To sum up, embodiment 4-6 proves that tincture of iodine bacteriostatic gel has outstanding fungistatic effect, nonirritant, and can effectively promote
Enter wound healing and, therefore tincture of iodine bacteriostatic gel has a extensive future as a kind of bacteriostatic gel of new promoting healing.
Claims (5)
1. a kind of bacteriostatic gel containing the tincture of iodine, it is characterised in that including following mass percent component：Tincture of iodine 0.5%-10%, macromolecule
Thickener 0.1%-3%, chitosan or chitin derivativ 0.1%-5%, zinc salt 0.05%-2%, alcohol 10%-75%, pure water 20%-
80%。
2. bacteriostatic gel according to claim 1, it is characterised in that the macromolecule thickener is hydroxyethyl methyl fiber
Element, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl hydroxyethyl cellulose, hydroxy propyl cellulose
One or more in element, carbomer or xanthans.
3. bacteriostatic gel according to claim 1, it is characterised in that the chitosan or chitin derivativ are Carboxylation
Chitosan, benzoylation chitosan, cyanoethyl chitosan, hydroxypropyl chitosan, Hydroxypropyl chitosan, hydroxyethyl chitosan, hydroxyl
Ethyl chitin, carboxymethyl chitosan, carboxymethyl chitin, carboxyetbyl chitosan, carboxyethyl chitin, succinyl-chitosan,
Succinyl chitin, sulfonated chitosan, sulfonated chitin, the benzaldehyde Schiff 's base of chitosan, N- ethyl chitosans, N- fourths
One kind in two acylation chitosans, N- maleylations chitosan, N- phthaloyl chitosans, N- Acetylated Chitosans
It is or several.
4. bacteriostatic gel according to claim 1, it is characterised in that the zinc salt is zinc lactate, zinc gluconate, acetic acid
One or more in zinc, Firebrake ZB, amino-acid zinc, licorzinc, zinc citrate, Firebrake ZB, zinc chloride, zinc acetate, Firebrake ZB.
5. a kind of preparation method of the bacteriostatic gel containing the tincture of iodine as claimed in claim 1, it is characterised in that comprise the following steps：（1）
Pure water, alcohol are added in reaction vessel, after adding zinc salt stirring and dissolving, macromolecule thickener is added, is heated to 30 DEG C ~ 45
DEG C, stirring at low speed 2-6 hours, 30 ~ 60min of high-speed stirred or at a high speed 10 ~ 40min of emulsification；（2）Add chitosan or chitin spreads out
Biology, the stirring at low speed 2-6 hours under the conditions of 30 DEG C ~ 45 DEG C, 10 ~ 40min of 30 ~ 60min of high-speed stirred or emulsification, stand 5-7
Hour makes its natural cooling be down to room temperature；（3）It is slowly added to tincture of iodine solution, 10 ~ 60min of high-speed stirred or emulsification, stirring at low speed
30 ~ 60min, lucifuge, it is sealed in stand in container and decolourizes, produce the bacteriostatic gel containing the tincture of iodine.
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| CN112111085A (en) * | 2018-12-11 | 2020-12-22 | 湖北一致魔芋生物科技股份有限公司 | Konjak gel carrier |
| CN112426561A (en) * | 2020-10-26 | 2021-03-02 | 上海迪派生物科技有限公司 | Hydrogel with continuous antibacterial ability |
| CN115105624A (en) * | 2022-08-26 | 2022-09-27 | 广东海洋大学 | Marine polysaccharide-based efficient antibacterial film dressing and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112111085A (en) * | 2018-12-11 | 2020-12-22 | 湖北一致魔芋生物科技股份有限公司 | Konjak gel carrier |
| CN112426561A (en) * | 2020-10-26 | 2021-03-02 | 上海迪派生物科技有限公司 | Hydrogel with continuous antibacterial ability |
| CN115105624A (en) * | 2022-08-26 | 2022-09-27 | 广东海洋大学 | Marine polysaccharide-based efficient antibacterial film dressing and preparation method thereof |
| CN115105624B (en) * | 2022-08-26 | 2022-11-08 | 广东海洋大学 | Marine polysaccharide-based efficient antibacterial film dressing and preparation method thereof |
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| CN107744524B (en) | 2020-08-25 |
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