CN105169455B - A kind of burn and scald external application first aid medical dressing and preparation method thereof - Google Patents
A kind of burn and scald external application first aid medical dressing and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to medical dressing technical fields, and in particular to a kind of burn and scald external application first aid medical dressing and preparation method thereof, the burn and scald external application first aid medical dressing includes the raw material of following parts by weight：37 parts of 40 50 parts of chitosan quaternary ammonium salt, 25 35 parts of indigo naturalis powder, 8 12 parts of moisturizer, 37 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract, 37 parts of Radix Sangusorbae extract and Herba Lycopi extract.The burn and scald external application first aid medical dressing energy quick-acting haemostatic powder of the present invention, analgesic, shield wound go trace, while the growth that can be inhibited bacteria, good with surface of a wound applicating property；Play an important role of to alleviate wound pain, control local infection, keep surface of a wound skin wet, protection skin, accelerate to promote the surface of a wound and wound healing, prevention scar formation; it can be widely used for the quick-acting haemostatic powder moisturizing burnt, scalded; first aid, treatment mitigate cicatrization.
Description
Technical field
The present invention relates to medical dressing technical fields, and in particular to a kind of burn and scald external application first aid medical dressing and its preparation
Method.
Background technology
In actual life, burn and scald phenomenon happens occasionally, and slight burn and scald person or use Western medicine or use Chinese medicine can obtain
The effect of to affirmative, but the epidermis at burn and scald position has scar to be difficult to eliminate；If serious burn and scald, situation is just different
Though with Western medicine or Chinese medicine or using skin grafting, all can only symptom management, preferable therapeutic effect is not achieved, and
And medical expense is expensive.
It is Chinese medicine preparation to be presently used for treatment laser to burn with the majority disclosed in the patent of burn and scald, document, is such as applied
Number disclose a kind of ice mound AgSD ointment for 03106944.4 Chinese invention patent；The China of Application No. 95119532.8
Patent of invention discloses a kind of ointment for treating burn and scald etc., these curative effect of medication are bad, and the treatment cycle is long, and application range is not extensive and is formulated
Preparation process is also more complicated, it is more difficult to promote and apply.
For a long time, people are generally the definition of medical dressing：To clean and protect the gauze of wound, meche,
The general name of cotton ball and cotton pad.The main function of dressing in this traditional definition is that wound is protected in wound healing process,
But to the healing of wound almost without facilitation.The Chinese utility model patent of Application No. 200920034872.4 discloses
A kind of to treat burn and scald, the active silver ion antiseptic dressing of wound, which is silver ion, have antibacterial,
Anti-inflammatory promotes the effect of wound healing, which is fixed using non-woven fabrics, since non-woven fabrics and wound are easy to adhesion, more
Secondary damage is likely to result in during change dressings.
1962, British scientist George doctors Winter had found that moist environmental benefits are in wound healing.Since then,
Various new-type dressing based on this thought have obtained extensive development, such as hydrocolloid dressing, aerogel dressing.Hydrogel
Dressing absorbs a large amount of wound effluxes, air permeable humidity retaining, and the transparent healing that can observe wound with that can be relieved pain
The advantages that situation, obtains the most attention of various countries.The Chinese invention patent of Application No. 200410010849.3 discloses one kind
The polyvinyl alcohol hydrogel dressing of drug containing, chitosan, the medical hydrogel dressings can be used for treating various skin traumas and burning
Scald, but the dressing does not have biocidal property, when wound is infected or having infected possible, it is impossible to use the dressing.
The Chinese invention patent of Application No. 201110044042.1 discloses one kind and contains nano silver and carboxymethyl chitosan medical dressing,
With preferable antibiotic effect, but the medical dressing preparation process is excessively complicated, and when preparation needs freeze-drier, manufacturing cost compared with
Height, the dressing freeze rear moisture-free, it is possible that adhesion can be generated with wound during use, and run counter to wet environment beneficial to wound
The theory of healing.The Chinese invention patent of Application No. 200610083191.8, which discloses one kind, to be had promotion wound healing, resists
The liquid of bacterium function（Gelatinous）Wound dressing, for the liquid dressing mainly using nano silver as antiseptic, prepared by nano silver
Journey complexity is cumbersome, and research in recent years shows that nano silver can deposit in vivo after being absorbed, and toxicity is big.
The content of the invention
In order to overcome shortcoming and defect in the prior art, it is an object of the invention to provide a kind of burn and scald external applications
First aid medical dressing, the burn and scald external application first aid medical dressing energy quick-acting haemostatic powder, analgesic, shield wound are removed trace, while can be inhibited thin
The growth of bacterium is good with surface of a wound applicating property；With alleviation wound pain, control local infection, keep surface of a wound skin wet, protection skin
Skin accelerates the effect that the surface of a wound and wound healing, prevention scar is promoted to be formed, and the quick-acting haemostatic powder that can be widely used for burning, scalding is protected
Wet, first aid, treatment mitigate cicatrization.
Another object of the present invention is to provide a kind of preparation method of burn and scald external application first aid medical dressing, the preparation side
Method is simple for process, and raw material is cheap and easy to get, and convenient operation and control, production cost is low, can large-scale industrial production.
The purpose of the present invention is achieved through the following technical solutions：A kind of burn and scald external application first aid medical dressing, described burn are scalded
Hindering external application first aid medical dressing includes the raw material of following parts by weight：
40-50 parts of chitosan quaternary ammonium salt
25-35 parts of indigo naturalis powder
8-12 parts of moisturizer
3-7 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
3-7 parts of Radix Sangusorbae extract
3-7 parts of Herba Lycopi extract.
Preferably, the burn and scald external application first aid medical dressing includes the raw material of following parts by weight：
40-45 parts of chitosan quaternary ammonium salt
25-30 parts of indigo naturalis powder
8-10 parts of moisturizer
3-5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
3-5 parts of Radix Sangusorbae extract
3-5 parts of Herba Lycopi extract.
Preferably, the burn and scald external application first aid medical dressing includes the raw material of following parts by weight：
42-48 parts of chitosan quaternary ammonium salt
28-32 parts of indigo naturalis powder
9-11 parts of moisturizer
4-6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
4-6 parts of Radix Sangusorbae extract
4-6 parts of Herba Lycopi extract.
Preferably, the burn and scald external application first aid medical dressing includes the raw material of following parts by weight：
45-50 parts of chitosan quaternary ammonium salt
30-35 parts of indigo naturalis powder
10-12 parts of moisturizer
5-7 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
5-7 parts of Radix Sangusorbae extract
5-7 parts of Herba Lycopi extract.
Preferably, the burn and scald external application first aid medical dressing includes the raw material of following parts by weight：
45 parts of chitosan quaternary ammonium salt
30 parts of indigo naturalis powder
10 parts of moisturizer
5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
5 parts of Radix Sangusorbae extract
5 parts of Herba Lycopi extract.
Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Sangusorbae extract and the Herba Lycopi extract that the present invention uses are commercially available Chinese medical extract.This
The effect for inventing each raw material used is as follows：
Chitosan：It is inhibited to the growth of various bacteria, show the feature of similar antibiotic.Chitosan is to table
The experimental strains such as skin staphylococcus, staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa, Candida albicans have
There are inhibitory action or even the Candida albicans for being difficult to inhibit to general antibiotic also to have inhibitory action.Macromolecular chitosan passes through
The interaction of the positive charge of the institute's band of itself and the negative electrical charge entrained by microbial cell film destroys the original knot of bacteria cell wall
Structure causes the leakage of cell component and plays antibacterial action.And the chitosan of small molecule, it is intracellular with the moon by penetrating into
The large biological molecule of ion occurs similar to " flocculation " effect, to upset the normal physiological function of cell, the biosynthesis of blocking dna,
So as to the breeding and growth that inhibit bacteria.As main disinfection component, it is proportionally added into mixture, it is therefore an objective to pass through it
Characteristic assists polyhexamethylene guanide, the residual bacterial do not killed completely is made to lose vitality, so as to reach enhancing sterilization effect.
The healing of the surface of a wound or wound is very important for patient, and wound mainly includes platelet aggregation, blood coagulates
Gu, fibrin formation, inflammatory reaction generation, matrix variation, cell Proliferation and regeneration, repair of damaged tissues and remodeling waited
Journey.Chitosan can promote the regeneration of epithelial cell, be proliferated to promote wound healing by mediated cell, pass through mild acute inflammation
Property reaction substantial amounts of polymorphonuclear cell and macrophage is attracted to remove fragment of tissue and blood clot.Chitosan can promote fiber finer
The migration of born of the same parents has stroma cell chemotactic, migration, activation, and accelerates cell Proliferation and tissue remodeling process, promotes skin
Tissue repair.The catabolite N-acetyl-glucosamine of chitosan（NAG）The scar of tissue is repaired extremely important.Chitosan is in itself
With anastalsis.Meanwhile chitosan mainly makees the aggegation of red blood cell by its interaction between erythrocyte membrane
With and realize hemostasis.Its hemostatic mechanism is：Positively charged chitosan and the negatively charged neuraminic acid residue of cell surface
Receptor interacts, and promotes hematoblastic aggregation, activates blood coagulation system, and crosslinking red blood cell forms clot.And chitosan
With apparent film formation effect, with accelerating wound healing and massive haemorrhage can be prevented.
The water solubility of chitosan quaternary ammonium salt is got well than chitin and chitosan, can preferably play the work(of chitosan
Effect.Chitosan quaternary ammonium salt not only has good biocompatibility, but also with the unexistent higher solubility of general chitosan
Easily by the function of many uniquenesses such as organism absorption, the biological activity of chitosan preferably make use of.The present invention passes through
Using chitosan quaternary ammonium salt, there is stronger antimicrobial antiphlogistic effect compared with existing dressing, at the same also solve chitosan cannot
The problem of hydrogel causes to mix unevenness is formed in neutral solution.
Indigo naturalis powder：Effect：It is clearing heat and detoxicating, cool blood, arresting convulsion；It cures mainly：For treating febrile virulent maculae, blood-head tells nosebleed, pectoralgia cough
Blood, aphtha, mumps, larynx numbness, pediatric epilepsy scared.
Pseudobulbus Bletillae (Rhizoma Bletillae) extract：It is bitter in taste, sweet, puckery, it is slightly cold；Channel tropism：Return lung, liver, stomach；Effect：Astringing to arrest bleeding, detumescence life
Flesh；It cures mainly：For spitting blood, haematemesis, traumatic hemorrhage, sore swollen toxin, chapped skin.
Radix Sangusorbae extract：Cold nature, bitter；Effect：With blood-stanching and blood-cooling, clearing heat and detoxicating, astringing to arrest diarrhea and inhibit a variety of
The effect of pathogenic microorganisms and tumour；It cures mainly：Haematemesis, bloody flux can be treated, to burn wound, eczema, upper gastrointestinal bleeding, canker big
Bleeding, have blood in stool, uterine bleeding, the diseases such as Tuberculous purulence ulcer and chronic osteomyelitis.
Herba Lycopi extract：Nature and flavor are acrid in flavour and warm in nature；Channel tropism：Enter lung, spleen, kidney channel；Effect：Wind dispelling eases pain；It cures mainly：Rheumatic numbness, pass
Save the diseases such as pain, leprosy, stomachache and flu, influenza fever, Enterozoa.
The burn and scald external application first aid medical dressing of the present invention generates simultaneously by using chitosan quaternary ammonium salt, chitosan quaternary ammonium salt
The cation energy quick-acting haemostatic powder of formation, analgesic, shield wound remove trace, and the work of isolation and killing is played to bacterium, fungi, virus
With；By using indigo naturalis powder, there is clearing heat and detoxicating, detumescence, hemostasis, analgesic, blood cooling and ecchymoses removing, purging intense heat arresting convulsion；By adopting
With moisturizer, skin care and moisturizing can be played the role of；By using Pseudobulbus Bletillae (Rhizoma Bletillae) extract, there is astringing to arrest bleeding, detumescence and promoting granulation
Effect；By using Radix Sangusorbae extract, there is cooling blood and hemostasis, detoxification sore treatment；By using Herba Lycopi extract, have and live
The effect of blood the Eradicates stasis of blood, line water detumescence.
The burn and scald external application first aid medical dressing of the present invention adds in indigo naturalis by using chitosan quaternary ammonium salt and moisturizer
Powder, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Sangusorbae extract and Herba Lycopi extract plurality of Chinese compounding use, and the weight of each raw material is strictly controlled to match somebody with somebody
Than energy quick-acting haemostatic powder, analgesic, shield wound go trace, while the growth that can be inhibited bacteria, good with surface of a wound applicating property；Hinder with alleviating
Mouth pain, control local infection keep surface of a wound skin wet, protection skin, accelerate the promotion surface of a wound and wound healing, prevention scar
The effect of formation, can be widely used for the quick-acting haemostatic powder moisturizing burnt, scalded, and first aid, treatment mitigate cicatrization.
Preferably, the chitosan quaternary ammonium salt includes 2- hydroxypropyl-trimethyl ammonium chloride shell of the quaternized degree for 70%-95%
The dimethyl diallyl ammonium chloride chitosan that glycan and/or quaternized degree are >=80%.
It is more highly preferred to, the chitosan quaternary ammonium salt is the 2- Hydroxyproyl Trimethyl chlorinations for 92%-95% by quaternized degree
Ammonium chitosan and quaternized degree are the dimethyl diallyl ammonium chloride chitosan of 95%-98% with weight ratio 2.5-3.5:1 composition
Mixture.
The present invention is by using above-mentioned chitosan quaternary ammonium salt, the property not only with typical quaternary ammonium salt, such as antibacterial bacteriostatic
Property and moisture absorbability and moisture retentivity, and maintain the original good film forming of chitosan, flocculability, biocompatibility and biodegradation etc.
Performance；Burn and scald external application first aid medical dressing quick-acting haemostatic powder, analgesic, shield wound remove trace made from enabling, and to bacterium, fungi, disease
Poison plays the role of isolation and killing.
Preferably, the moisturizer for fusing point 88-102 DEG C, relative density 1.45-1.53 sorbierite.
The present invention by using fusing point 88-102 DEG C, relative density 1.45-1.53 sorbierite as moisturizer, can
To improve the humidity of skin, wound dehydrates are prevented, maintain to be conducive to the wet environment for the treatment of in wound, improve therapeutic effect,
Promote wound healing.
Preferably, the burn and scald external application first aid medical dressing further includes 1-5 parts of stabilizer, stabilizer be by xylitol,
Mannitol and disodium ethylene diamine tetraacetate are with weight ratio 1.5-2.5：1：The mixture of 0.5-1.5 compositions.
The present invention, as stabilizer, and controls its weight by using xylitol, mannitol and disodium ethylene diamine tetraacetate
Than for 1.5-2.5：1：0.5-1.5 can maintain the stability of burn and scald external application first aid medical dressing.
Another object of the present invention is achieved through the following technical solutions：A kind of preparation of burn and scald external application first aid medical dressing
Method includes the following steps：
Step A, weigh：The chitosan quaternary ammonium salt of weighing formula ratio, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet extraction
Object and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet
Extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
The preparation method of the present invention is simple for process, and raw material is cheap and easy to get, and convenient operation and control, production cost is low, can advise greatly
Mould industrialized production.
The beneficial effects of the present invention are：The burn and scald external application first aid medical dressing of the present invention is by using chitosan quaternary ammonium
Salt, the cation that chitosan quaternary ammonium salt is generated and formed can quick-acting haemostatic powder, analgesic, shield wound remove trace, and to bacterium, fungi, virus
Play the role of isolation and killing；By using indigo naturalis powder, there is clearing heat and detoxicating, detumescence, hemostasis, analgesic, blood cooling and ecchymoses removing, rush down
The effects that fire arresting convulsion；By using moisturizer, skin care and moisturizing can be played the role of；By using Pseudobulbus Bletillae (Rhizoma Bletillae) extract, have
The effect of astringing to arrest bleeding, detumescence and promoting granulation；By using Radix Sangusorbae extract, there is cooling blood and hemostasis, detoxification sore treatment；By adopting
With Herba Lycopi extract, there is invigorate blood circulation the Eradicates stasis of bloods, line water detumescence.
The burn and scald external application first aid medical dressing of the present invention adds in indigo naturalis by using chitosan quaternary ammonium salt and moisturizer
Powder, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Sangusorbae extract and Herba Lycopi extract plurality of Chinese compounding use, and the weight of each raw material is strictly controlled to match somebody with somebody
Than energy quick-acting haemostatic powder, analgesic, shield wound go trace, while the growth that can be inhibited bacteria, good with surface of a wound applicating property；Hinder with alleviating
Mouth pain, control local infection keep surface of a wound skin wet, protection skin, accelerate the promotion surface of a wound and wound healing, prevention scar
The effect of formation, can be widely used for the quick-acting haemostatic powder moisturizing burnt, scalded, and first aid, treatment mitigate cicatrization.
The burn and scald external application first aid medical dressing of the present invention has the following advantages that：
（1）Flap coverage, antiphlogistic antibacterial, especially to proteus, staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli,
A variety of pathogens such as Candida albicans, staphylococcus epidermis, gonococcus have stronger bacteriolysis, can effectively prevent wound sense
Dye, exanthemv；
（2）Styptic powder addiction, the effect of detumescence ding-tong；
（3）Promote granulation growth and skin regeneration, healing acceleration reduces scar；
（4）With with human skin similar in softness, moistening when can also keep certain form and intensity；
（5）Good permeability can keep moist environment, there is the preferable ability for absorbing wound exudate；
（6）Heat source response does not occur；
（7）Good biocompatibility, non-stimulated, non-immunogenicity nontoxic to the various surface of a wound；
（8）All kinds of burn and scalds can be effectively cured, anti-infection ability is strong, and effect is fast, and the burn and scald within 30% area is not
It needs to make skin graft.
The preparation method of the present invention is simple for process, and raw material is cheap and easy to get, and convenient operation and control, production cost is low, can advise greatly
Mould industrialized production.
Specific embodiment
For the ease of the understanding of those skilled in the art, with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of burn and scald external application first aid medical dressing, the burn and scald external application first aid medical dressing include following parts by weight
Raw material：
40 parts of chitosan quaternary ammonium salt
25 parts of indigo naturalis powder
8 parts of moisturizer
3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
3 parts of Radix Sangusorbae extract
3 parts of Herba Lycopi extract.
It by quaternized degree is 92% 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized that the chitosan quaternary ammonium salt, which is,
The dimethyl diallyl ammonium chloride chitosan for 95% is spent with weight ratio 2.5:The mixture of 1 composition.
The moisturizer is fusing point in 88 DEG C, sorbierite of the relative density 1.45.
The burn and scald external application first aid medical dressing further includes 1 part of stabilizer, and stabilizer is by xylitol, mannitol and second
Edetate disodium is with weight ratio 1.5：1：The mixture of 0.5 composition.
A kind of preparation method of burn and scald external application first aid medical dressing, includes the following steps：
Step A, weigh：Weigh the chitosan quaternary ammonium salt of formula ratio, indigo naturalis powder, moisturizer, stabilizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract,
Radix Sangusorbae extract and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, stabilizer, bletilla extraction
Object, Radix Sangusorbae extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
Clinical practice example 1：Mr. Zhang, 45 years old, symptom was skin burn, using the burn and scald external application of the embodiment of the present invention 1
First aid medical dressing, daily wound dressing three times, after being used continuously 15 days, do not infect, wound healing is good.
Embodiment 2
A kind of burn and scald external application first aid medical dressing, the burn and scald external application first aid medical dressing include following parts by weight
Raw material：
42 parts of chitosan quaternary ammonium salt
28 parts of indigo naturalis powder
9 parts of moisturizer
4 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
4 parts of Radix Sangusorbae extract
4 parts of Herba Lycopi extract.
It by quaternized degree is 93% 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized that the chitosan quaternary ammonium salt, which is,
The dimethyl diallyl ammonium chloride chitosan for 96% is spent with weight ratio 2.8:The mixture of 1 composition.
The moisturizer is fusing point in 89 DEG C, sorbierite of the relative density 1.47.
A kind of preparation method of burn and scald external application first aid medical dressing, includes the following steps：
Step A, weigh：The chitosan quaternary ammonium salt of weighing formula ratio, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet extraction
Object and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet
Extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
Clinical practice example 2：Mrs Zeng, 26 years old, symptom was skin scald, using the burn and scald external application of the embodiment of the present invention 2
First aid medical dressing, daily wound dressing three times, after being used continuously 15 days, do not infect, wound healing is good.
Embodiment 3
A kind of burn and scald external application first aid medical dressing, the burn and scald external application first aid medical dressing include following parts by weight
Raw material：
45 parts of chitosan quaternary ammonium salt
30 parts of indigo naturalis powder
10 parts of moisturizer
5 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
5 parts of Radix Sangusorbae extract
5 parts of Herba Lycopi extract.
It by quaternized degree is 94% 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized that the chitosan quaternary ammonium salt, which is,
The dimethyl diallyl ammonium chloride chitosan for 97% is spent with weight ratio 3:The mixture of 1 composition.
The moisturizer is fusing point in 100 DEG C, sorbierite of the relative density 1.49.
The burn and scald external application first aid medical dressing further includes 3 parts of stabilizer, and stabilizer is by xylitol, mannitol and second
Edetate disodium is with weight ratio 2：1：The mixture of 1 composition.
A kind of preparation method of burn and scald external application first aid medical dressing, includes the following steps：
Step A, weigh：Weigh the chitosan quaternary ammonium salt of formula ratio, indigo naturalis powder, moisturizer, stabilizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract,
Radix Sangusorbae extract and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, stabilizer, bletilla extraction
Object, Radix Sangusorbae extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
Clinical practice example 3：Mr. Yang, 37 years old, symptom was skin burn, using the burn and scald external application of the embodiment of the present invention 3
First aid medical dressing, daily wound dressing three times, after being used continuously 15 days, do not infect, wound healing is good.
Embodiment 4
A kind of burn and scald external application first aid medical dressing, the burn and scald external application first aid medical dressing include following parts by weight
Raw material：
48 parts of chitosan quaternary ammonium salt
32 parts of indigo naturalis powder
11 parts of moisturizer
6 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
6 parts of Radix Sangusorbae extract
6 parts of Herba Lycopi extract.
It by quaternized degree is 94% 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized that the chitosan quaternary ammonium salt, which is,
The dimethyl diallyl ammonium chloride chitosan for 97% is spent with weight ratio 3.2:The mixture of 1 composition.
The moisturizer is fusing point in 101 DEG C, sorbierite of the relative density 1.51.
A kind of preparation method of burn and scald external application first aid medical dressing, includes the following steps：
Step A, weigh：The chitosan quaternary ammonium salt of weighing formula ratio, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet extraction
Object and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet
Extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
Clinical practice example 4：Mr. Zhao, 41 years old, symptom was skin scald, using the burn and scald external application of the embodiment of the present invention 4
First aid medical dressing, daily wound dressing three times, after being used continuously 15 days, do not infect, wound healing is good.
Embodiment 5
A kind of burn and scald external application first aid medical dressing, the burn and scald external application first aid medical dressing include following parts by weight
Raw material：
50 parts of chitosan quaternary ammonium salt
35 parts of indigo naturalis powder
12 parts of moisturizer
7 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extract
7 parts of Radix Sangusorbae extract
7 parts of Herba Lycopi extract.
It by quaternized degree is 95% 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized that the chitosan quaternary ammonium salt, which is,
The dimethyl diallyl ammonium chloride chitosan for 98% is spent with weight ratio 3.5:The mixture of 1 composition.
The moisturizer is fusing point in 102 DEG C, sorbierite of the relative density 1.53.
The burn and scald external application first aid medical dressing further includes 5 parts of stabilizer, and stabilizer is by xylitol, mannitol and second
Edetate disodium is with weight ratio 2.5：1：The mixture of 1.5 compositions.
A kind of preparation method of burn and scald external application first aid medical dressing, includes the following steps：
Step A, weigh：Weigh the chitosan quaternary ammonium salt of formula ratio, indigo naturalis powder, moisturizer, stabilizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract,
Radix Sangusorbae extract and Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, stabilizer, bletilla extraction
Object, Radix Sangusorbae extract and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
Clinical practice example 5：Mrs Zhong, 28 years old, symptom was skin burn, using the burn and scald external application of the embodiment of the present invention 5
First aid medical dressing, daily wound dressing three times, after being used continuously 15 days, do not infect, wound healing is good.
Clinical observation on the therapeutic effect the results show that the present invention burn and scald external application first aid medical dressing energy quick-acting haemostatic powder, analgesic, shield
Wound goes trace, while the growth that can be inhibited bacteria, good with surface of a wound applicating property；With alleviation wound pain, control local infection, protect
It holds surface of a wound skin wet, protection skin, accelerate the effect that the surface of a wound and wound healing, prevention scar is promoted to be formed, can be widely used for
The quick-acting haemostatic powder moisturizing of burn, scald, first aid, treatment mitigate cicatrization.
Pharmacology test is carried out respectively to burn and scald external application first aid medical dressing made from embodiment 1-5, experimental result is as follows：
Test 1：Fungistatic effect
It presses《Drug Micro biological Tests handbook》18th chapter Section 1 cylinder-plate method is tested, and measurement result is referring to table 1.
Table 1
| Bacteriostatic diameter (mm) | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Staphylococcus aureus | 21.6±0.9 | 22.4±0.7 | 22.1±0.8 | 23.2±0.9 | 21.7±0.6 |
| Escherichia coli | 18.1±0.7 | 19.2±0.6 | 18.5±0.9 | 19.6±1.0 | 20.3±0.8 |
| Candida albicans | 23.5±0.9 | 24.1±0.7 | 23.2±0.8 | 24.4±0.7 | 25.2±0.6 |
| Pseudomonas aeruginosa | 13.8±1.0 | 14.2±0.9 | 13.6±0.6 | 14.5±0.9 | 15.2±0.8 |
As it can be seen from table 1 burn and scald external application first aid medical dressing produced by the present invention has apparent inhibition zone, illustrate pair
The growth of gold-coloured staphylococci, Escherichia coli, Candida albicans, Pseudomonas aeruginosa has obvious inhibiting effect.
Test 2：Liquid dressing sample skin irritation index（PII）It measures
Closed sensitization test (STT) method is measured as defined in GB/T16886.10-2000, and testing result is referring to table 2.
Table 2
| Test event | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Skin irritation index | 0 | 0 | 0 | 0 | 0 |
| Sensitization of skin | Nothing | Nothing | Nothing | Nothing | Nothing |
From table 2 it can be seen that burn and scald external application first aid medical dressing produced by the present invention is caused without skin irritatin and skin
Quick reaction.
Test 3：Biocompatibility experiment
The burn and scald external application first aid medical dressing of embodiment 1-5 is injected separately into white rabbit body, timing is observed, continuous 8 days
Weight, feed, body temperature, activity are without exception.Illustrate that burn and scald external application first aid medical dressing produced by the present invention has good life
Object compatibility.
Test 4：To the contrast test of traumatic wounds healing
Test sample：Burn and scald external application first aid medical dressing made from embodiment 1-5, reference substance Yunnan Baiyao.
1st, hemostasis effect
Coagulation time test method：Each test samples of 10mg are taken respectively, new blood 1mL is added in, shakes up, and record blood clotting
Time the results are shown in Table 3.
Table 3
| Clotting time（min） | Normal coagulation | Yunnan Baiyao | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 1 | 9.36 | 8.65 | 5.54 | 5.89 | 5.75 | 5.92 | 5.64 |
| 2 | 9.17 | 8.34 | 5.90 | 5.69 | 7.04 | 5.56 | 5.06 |
| 3 | 8.95 | 8.91 | 5.57 | 5.93 | 5.85 | 5.91 | 5.78 |
| Average value | 9.16 | 8.63 | 5.67 | 5.84 | 5.88 | 5.80 | 5.83 |
| In advance | 0.00 | 5.79% | 38.10% | 36.24% | 35.80% | 36.68% | 41.15% |
From table 3 it can be seen that burn and scald external application first aid medical dressing produced by the present invention shows blood coagulation resisting function, and just
The normal clotting time compares, and the burn and scald external application first aid medical dressing clotting time averagely shifts to an earlier date 37.65%, hence it is evident that white better than Yunnan
Medicine.
2nd, wound healing effect is promoted
Experimental animal uses male Wister rat, every group of 10 animals.3 after wound, 6,10,15,21d observation.
Rat back is lost hair or feathers with 8% vulcanized sodium liquid, gives yellow Jackets through abdominal cavity afterwards for 24 hours, is cut directly with operating scissors after anaesthetizing successfully
The full skin notch of circle that footpath is about 1.0cm, is sterilized with 70% alcoholic solution, respectively by the burn and scald external application obtained by embodiment 1-5
First aid medical dressing is coated on wound, is covered with paraffin degreasing gauze, then bandages, and physiology salt is given through abdominal cavity after wound
Water.Respectively by the burn and scald external application first aid medical dressing flap coverage obtained by embodiment 1-5, as test group 1-5；Control group is used
0.2% calculates Wound healing rate according to husky bifurcation pyridine solution treatment, wrapping in each sampling time point.
The method for calculating Wound healing rate is as follows：First by surface of a wound mark on onionskin, then as template, by quality
Uniformly hard paper is cut into onesize, then weighs weight in the balance, surface of a wound size is indirectly indicative with cardboard sheet weight.
It presses examination and calculates Wound healing rate：
Wound healing rate（%）=（Original surface of a wound area-do not heal surface of a wound area）/ original surface of a wound area.
Pathologic finding understands wound healing quality, and determines healing time, experimental result such as table according to wound healing situation
Shown in 4：
Table 4
| Sample number of days | 3d | 6 d | 10 d | 15 d | 21 d |
| Control group | 4.6±0.9 | 10.5±1.1 | 30.7±1.2 | 51.2±0.9 | 76.5±1.0 |
| Embodiment 1 | 21.1±1.3 | 34.6±1.1 | 67.2±1.2 | 88.4±1.0 | 97.3±1.3 |
| Embodiment 2 | 23.3±1.1 | 35.9±0.9 | 61.5±1.3 | 87.7±1.1 | 99.2±1.2 |
| Embodiment 3 | 22.7±0.9 | 39.3±1.1 | 64.1±1.0 | 88.4±1.2 | 97.8±1.3 |
| Embodiment 4 | 24.5±1.0 | 39.6±1.3 | 68.8±0.9 | 86.6±1.4 | 98.5±1.1 |
| Embodiment 5 | 23.2±1.2 | 36.4±1.0 | 66.5±1.2 | 87.2±1.2 | 98.9±0.9 |
As shown in Table 4, after burn and scald external application first aid medical dressing of the invention application, the surface of a wound of each sample point averagely heals
Rate is above control group, and the surface of a wound is averaged healing rate as more than 97% at 21 days, higher than control group more than 20%, illustrates the present invention
Burn and scald external application first aid medical dressing promote wound healing effect it is very good.
Above-described embodiment is the preferable implementation of the present invention, and in addition, the present invention can be realized with other manner,
Any obvious replacement is not departed from the premise of present inventive concept within protection scope of the present invention.
Claims (8)
1. a kind of burn and scald external application first aid medical dressing, it is characterised in that：The burn and scald external application first aid medical dressing is included such as
The raw material of lower parts by weight：
The chitosan quaternary ammonium salt include it is quaternized degree for 70%-95% 2- hydroxypropyltrimethylammonium chloride chitosan and/or
The dimethyl diallyl ammonium chloride chitosan that quaternized degree is >=80%；
The moisturizer for fusing point 88-102 DEG C, relative density 1.45-1.53 sorbierite.
2. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The burn and scald external application
First aid medical dressing includes the raw material of following parts by weight：
3. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The burn and scald external application
First aid medical dressing includes the raw material of following parts by weight：
4. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The burn and scald external application
First aid medical dressing includes the raw material of following parts by weight：
5. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The burn and scald external application
First aid medical dressing includes the raw material of following parts by weight：
6. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The chitosan quaternary ammonium
The 2- hydroxypropyltrimethylammonium chloride chitosan and quaternized degree that it is 92%-95% by quaternized degree that salt, which is, are 95%-98%'s
Dimethyl diallyl ammonium chloride chitosan is with weight ratio 2.5-3.5:The mixture of 1 composition.
7. a kind of burn and scald external application first aid medical dressing according to claim 1, it is characterised in that：The burn and scald external application
First aid medical dressing further includes 1-5 parts of stabilizer, and stabilizer is with weight by xylitol, mannitol and disodium ethylene diamine tetraacetate
Compare 1.5-2.5：1：The mixture of 0.5-1.5 compositions.
8. such as a kind of preparation method of burn and scald external application first aid medical dressing of claim 1-6 any one of them, feature exists
In：Include the following steps：
Step A, weigh：Weigh the chitosan quaternary ammonium salt of formula ratio, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Radix Sangusorbae extract and
Herba Lycopi extract；
Step B, prepare：By the load weighted chitosan quaternary ammonium salts of step A, indigo naturalis powder, moisturizer, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, garden burnet extraction
Object and Herba Lycopi extract, which are put into container, to be stirred until homogeneous to get burn and scald external application first aid medical dressing.
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| CN105581942A (en) * | 2015-12-31 | 2016-05-18 | 天津保元堂生物科技有限公司 | Chitosan aloe burn and scald gel and preparation method thereof |
| CN105770984A (en) * | 2016-03-14 | 2016-07-20 | 宁波市江东林清环保科技有限公司 | Preparation method of modified chitosan-based hemostatic sponge |
| CN109568650A (en) * | 2018-12-19 | 2019-04-05 | 广州润虹医药科技股份有限公司 | A kind of chitosan quaternary ammonium salt antiseptic dressing and preparation method thereof |
| CN111407919B (en) * | 2020-03-18 | 2022-05-13 | 天津市康婷生物工程集团有限公司 | Chitosan quaternary ammonium salt sterilization gauze and preparation method thereof |
| CN116808141A (en) * | 2023-06-21 | 2023-09-29 | 浙江医鼎医用敷料有限公司 | Wound care ointment and preparation method thereof |
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| CN1887358A (en) * | 2006-07-14 | 2007-01-03 | 青岛博益特生物材料有限公司 | Medical chitosan dressing and its application |
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