CN107753937A - A kind of wound disinfection agent and preparation method thereof - Google Patents
A kind of wound disinfection agent and preparation method thereof Download PDFInfo
- Publication number
- CN107753937A CN107753937A CN201610692608.4A CN201610692608A CN107753937A CN 107753937 A CN107753937 A CN 107753937A CN 201610692608 A CN201610692608 A CN 201610692608A CN 107753937 A CN107753937 A CN 107753937A
- Authority
- CN
- China
- Prior art keywords
- wound
- disinfection agent
- effect
- chitosan
- wound disinfection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
Abstract
The invention discloses a kind of wound disinfection agent, the lysozyme chloride and Chlorhexidine wherein included is main disinfection composition, both cooperatively form composite disinfecting bactericide, it ensure that bactericidal effect, the addition of chitosan improves the stability of disinfectant solution, there is promotion wound healing simultaneously, prevent the effect of scar hyperplasia；Tranexamic acid is main hemostatic compositions, produces synergy with chitosan, strengthens haemostatic effect；After chitosan coordinates with carboxymethyl cellulose, skin wound is sprayed at, elastic protective film can be formed, the medicine retention time is added, plays wound healing, protects the effect of the surface of a wound；The addition of glycerine causes disinfectant to have the effect of surface of a wound moisturizing, while enhances the elastic reaction of elastic protective film.Wound surface is handled using wound disinfection agent provided by the invention, excitant is small, Disinfection Effect is good, not pollution clothes, easy to use easy to maintain, and have both sterilization, hemostasis, promoting healing triple function simultaneously.
Description
Technical field
The invention belongs to external used medicine technical field, and in particular to a kind of wound disinfection agent and preparation method thereof.
Background technology
As global climate becomes the deterioration of warm environmental pollution, the species of various microorganisms particularly invasive organism
Constantly rising with procreation speed, thus triggering the incidence of disease of the various diseases of human body and animal also rapid soaring therewith, because
The use of this disinfectant is particularly important.The application of disinfectant mainly has two broad aspects：One is air ambient, equipment are set
Apply, the sterilization of the body surface such as clothes utensil；The second is medical treatment aspect is to organism surfaces such as skin, mucous membrane, wound and the surface of a wound
Sterilization.The use of disinfectant should select different type and concentration according to different sterilization objects.In terms of medical treatment, at present most
There is sterilization ethanol for conventional disinfectant（75%）, the tincture of iodine, hydrogen peroxide, Iodophor, gentian violet etc., but sterilize ethanol（75%）And iodine
Wine is big to wound excitant, and patient's usage experience is bad, and inflammable and explosive is not easy to store；The disinfective action of hydrogen peroxide is weak,
It is oxygen-containing unstable, shelf-life short easily failure；The color of Iodophor and gentian violet is deeper, patient skin and clothes easy coloring, after dilution
Stability is poor, and needs to be kept in dark place.
Therefore, need that a kind of excitant of research and development is small, Disinfection Effect is good, not pollution clothes, easy to use easy to maintain badly, and
Have both sterilization, hemostasis, the disinfectant of promoting healing triple function simultaneously.
The content of the invention
It is an object of the invention to provide a kind of excitant is small, Disinfection Effect is good, not pollution clothes, the easy guarantor of user
Deposit, and have both sterilization, hemostasis, the wound disinfection agent of promoting healing triple function simultaneously.
The object of the present invention is achieved like this, comprising each group be divided into lysozyme chloride, Chlorhexidine,
Chitosan, tranexamic acid, carboxymethyl cellulose, glycerine and deionized water.
Counted using the wound disinfection agent overall volume as 100ml, wherein each component and its content that include are as follows：
1 ~ 2g lysozyme chloride；
0.05 ~ 0.1g Chlorhexidine；
2 ~ 5g chitosan；
0.3 ~ 0.5g tranexamic acid；
2 ~ 5g carboxymethyl cellulose；
3 ~ 5ml glycerine；
Remaining is deionized water.
Present invention also offers a kind of method for preparing the wound disinfection agent, comprise the following steps：
A, 50ml deionized waters are taken, chitosan, Chlorhexidine, the tranexamic acid dissolving of precise is then added, obtains solution A；
B, 30ml deionized waters are taken, lysozyme chloride, the carboxymethyl cellulose dissolving of precise is then added, obtains B solution；
C, the glycerine accurately measured is added after being stirred B solution and solution A, deionized water is added after stirring to complete
100ml constant volumes are measured, filtered through miillpore filter, dispensed and produce.
Lysozyme chloride used in the present invention is to gram positive bacteria, aerobic sporeformer, hay bacillus, lichens
Type bacillus etc. has antibacterial action, and will not have a negative impact to the human body cell of no cell membrane, while lysozyme
Can also with negatively charged virus protein directly in conjunction with, with DNA, RNA, apoprotein formed double salt, make virally inactivated.Cause
This, the enzyme has the effect such as antibacterial, anti-inflammatory, antiviral.In recent years, the Biostatic of lysozyme chloride, which has, greatly improves, because of it
With it is efficient, safe, non-stimulated, residual the characteristics of by foreign countries widely apply.
Chlorhexidine tradition has great broad-spectrum antibacterial, bactericidal action, has effect to various bacteria.
Chitosan has the function that promotion blood clotting, can be used as styptic.It can be additionally used in Wound filling material, have
Sterilize, promote wound healing, absorb Wound exudate, being not easy the effect such as syneresis.
Tranexamic acid also known as hemal ring acid, tranexamic acid, high-effective hemostatic.It is the main component that anastalsis is played in formula, and
Chitosan plays synergy, strengthens haemostatic effect.
Its aqueous solution of carboxymethyl cellulose has thickening, film forming, gluing, water tariff collection, colloid protection and other effects.
The lysozyme chloride and Chlorhexidine included in wound disinfection agent provided by the invention is main disinfection composition,
Both cooperatively form composite disinfecting bactericide, ensure that bactericidal effect, the addition of chitosan improves the stabilization of disinfectant solution
Property, while there is promotion wound healing, prevent the effect of scar hyperplasia；Tranexamic acid is main hemostatic compositions, with chitosan
Synergy is produced, strengthens haemostatic effect；After chitosan coordinates with carboxymethyl cellulose, skin wound is sprayed at, can be formed
Elastic protective film, the medicine retention time is added, plays wound healing, protect the effect of the surface of a wound；The addition of glycerine makes
Obtaining disinfectant has the effect of surface of a wound moisturizing, while enhances the elastic reaction of elastic protective film.Using wound provided by the invention
Mouthful disinfectant is handled wound surface, and excitant is small, Disinfection Effect is good, not pollution clothes, easy to use easy to maintain, and together
When have both sterilization, hemostasis, promoting healing triple function.
Embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention must not be added in any way
With limitation, based on present invention teach that any changes and modifications made, belong to protection scope of the present invention.Institute of the present invention simultaneously
It is commercially available prod unless otherwise instructed with raw material.
The preparation of wound disinfection agent
Embodiment 1
A, 50ml deionized waters are taken, then add 2g chitosans, 0.05g Chlorhexidines, 0.3g the tranexamic acids dissolving of precise,
Obtain solution A；
B, 30ml deionized waters are taken, 1g lysozyme chlorides, the dissolving of 2g carboxymethyl celluloses of precise is then added, obtains B
Solution；
C, the 3ml glycerine accurately measured is added after being stirred B solution and solution A, deionized water is added after stirring
Wound disinfection agent is produced to full dose 100ml constant volumes.
Embodiment 2
A, 50ml deionized waters are taken, then add 5g chitosans, 0.07g Chlorhexidines, 0.4g the tranexamic acids dissolving of precise,
Obtain solution A；
B, 30ml deionized waters are taken, 1.5g lysozyme chlorides, the dissolving of 3.5g carboxymethyl celluloses of precise is then added, obtains
To B solution；
C, the 4ml glycerine accurately measured is added after being stirred B solution and solution A, deionized water is added after stirring
Wound disinfection agent is produced to full dose 100ml constant volumes.
Embodiment 3
A, 50ml deionized waters are taken, then add 3g chitosans, 0.1g Chlorhexidines, 0.5g the tranexamic acids dissolving of precise,
Obtain solution A；
B, 30ml deionized waters are taken, 2g lysozyme chlorides, the dissolving of 5g carboxymethyl celluloses of precise is then added, obtains B
Solution；
C, the 5ml glycerine accurately measured is added after being stirred B solution and solution A, deionized water is added after stirring
Wound disinfection agent is produced to full dose 100ml constant volumes.
The bactericidal effect of wound disinfection agent
According to GB15981-1995<<Sterilization and the evaluation method and standard of sterilization effect>>Above three embodiment is prepared into
The wound disinfection agent of work(carries out sterilization experiment, specifically comprises the following steps：
1st, staphylococcus aureus (ATCC6538), the fresh inclined-plane cultures of Candida albicans (ATCC10231) 18~24h are taken
Thing, washed down with the 0.03mol/LPBS containing 10g/L peptones and be diluted to required concentration, mixed, bacteria suspension is made.Take
The 20 above-mentioned bacteria suspensions of μ l are contaminated on the sterile white plain weave pieces of cloth (10mm × 10mm) of degreasing, and bacterium piece is made.
2nd, nertralizer Selection experiment
Tested with staphylococcus aureus and Candida albicans according to carrier quantitation sterilisation program.Experiment carries out 6 groups of parallel surveys
Examination.Result judgement is pressed《Disinfection technology standard》Defined standard performs, and experiment repeats 3 times.As a result it is as follows：
The nertralizer authentication test results of table 1
Nertralizer Selection experiment result proves, with the PBS of the Tween 80 containing+1% lecithin of 0.5% sodium thiosulfate+3%
Solution meets defined standard as nertralizer.
3rd, carrier quantitative germicidal test
The wound disinfection agent sample that above three embodiment is successfully prepared installs the dosage packing of 1 bacterium piece 5ml disinfectant respectively
In plate, put in 20 ± 2 DEG C of water-baths to constant temperature.Test organisms piece is separately added into, acts on the stipulated time, bacterium piece is moved into and is equipped with
In the test tube of 5ml nertralizers, neutralization 10min, rapping elutes the bacterium on bacterium piece, mixes.Take aforesaid liquid or its dilution
Liquid 0.5ml is inoculated in plate, and pours into the agar medium needed for each bacterium, is cultivated by each bacterium condition of culture, does viable bacteria note
Number, calculate killing rate.Experiment repeats to average for 3 times.It the results are shown in Table 2-4.
The embodiment 1 of table 2 prepares sample sterilization test result
The embodiment 2 of table 3 prepares sample sterilization test result
The embodiment 3 of table 4 prepares sample sterilization test result
Above-mentioned result of the test shows that wound disinfection agent sample prepared by 3 embodiments provided by the invention, which is respectively provided with, preferably to kill
Bacterium effect.
The haemostatic effect experiment of wound disinfection agent
The wound disinfection agent sample being successfully prepared to above three embodiment carries out haemostatic effect experiment, specific as follows：
From the Female New Zealand White Rabbit 24 that body weight is 1.5 ± 0.25Kg, 4 groups, every group 6 are randomly divided into.
The method of bibliography makes rabbit arteria auricularis traumatic bleeding model, and using 1.5% yellow Jackets, dosage is 30mg/kg veins
Administration is anaesthetized.After anaesthetizing successfully, skin, manufacture 1cmx1cm bleeding wounds are peeled off under aseptic condition at the ear center of rabbit two
Face, cut off artery and vein.Control group is stopped blooding with antiseptic gauze；Experimental group is stopped blooding with sample 1ml+ antiseptic gauzes are prepared,
Bleeding part is observed every 20s, records bleeding stopping period and amount of bleeding.
Amount of bleeding is weighed gauze and empty measuring cup in advance with precision electronic balance, and measuring cup sealing is put it into after hemostasis and is claimed
Weight, calculates amount of bleeding, and result of the test is shown in Table 5.
The bleeding stopping period and amount of bleeding of the various concentrations wound disinfection agent of table 5
Above-mentioned result of the test shows that wound disinfection agent sample prepared by 3 embodiments provided by the invention is respectively provided with significantly
Haemostatic effect.
The film-formation result experiment of wound disinfection agent
5cmx10cm dry glass 3 is taken, the wound disinfection agent sample 1ml for taking above three embodiment to be successfully prepared respectively is equal
It is even to be coated on sheet glass, 50 DEG C of freeze-day with constant temperature 24h are carried out to it, take out observation, result of the test shows, provided by the invention 3
Wound disinfection agent sample prepared by individual embodiment can show to form elastic membrane in glass.
The wound healing effect experiment of wound disinfection agent
1st, animal prepares：SD rats 36 are taken, random point 4 groups, every group 9, shave back hair, defeathering scope 2cmx2cm, no
Skin must be damaged；
2nd, material prepares：0.5% Iodophor, the wound disinfection agent sample for taking above three embodiment to be successfully prepared；
The deep wounds of the long 1cm of deep 0.2cm are drawn at the position for getting hair ready in rat with scalpel, and control group is sprayed with 0.5% Iodophor, often
It is 3 times；The wound disinfection agent sample that test group is successfully prepared with three embodiments sprays respectively, 3 times a day；Observe and record wound
Mouth healing state and time.
The wound healing situation and cure time of the various concentrations wound disinfection agent of table 6
Above-mentioned result of the test shows that wound disinfection agent sample prepared by 3 embodiments provided by the invention is respectively provided with significantly
Promote wound healing effect.
The stability test of wound disinfection agent
The wound disinfection agent sample being successfully prepared to above three embodiment carries out Accelerated stability test, takes packaged three
Sample is placed in 37 DEG C of insulating boxs 3 months, and Chlorhexidine, tranexamic acid content and chlorination bacteriolyze in determination sample are distinguished after taking-up
The activity of enzyme, measurement result are as follows：
The stability test result of the various concentrations wound disinfection agent of table 7
Above-mentioned result of the test shows that wound disinfection agent sample prepared by 3 embodiments provided by the invention is respectively provided with preferably steady
It is qualitative.
Above-mentioned experiment shows that the stability of wound disinfection agent provided by the invention is up to standard, be provided simultaneously with bactericidal effect significantly,
Haemostatic effect is good, promotes wound healing, shortens the curative effects such as Wound healing time.
Above is the description to better embodiment of the present invention, and it is not understood to the limitation present invention, those skilled in the art
A variety of changes or combination can be made according to the present invention, without departing from the spirit of the present invention, the protection of the present invention all should be belonged to
Scope.
Claims (6)
- A kind of 1. wound disinfection agent, it is characterised in that：Comprising each group be divided into lysozyme chloride, Chlorhexidine,Chitosan, tranexamic acid, carboxymethyl cellulose, glycerine and deionized water.
- A kind of 2. wound disinfection agent, it is characterised in that：Counted using the wound disinfection agent overall volume as 100ml, wherein include Each component and its content are as follows：1 ~ 2g lysozyme chloride；0.05 ~ 0.1g Chlorhexidine；2 ~ 5g chitosan；0.3 ~ 0.5g tranexamic acid；2 ~ 5g carboxymethyl cellulose；3 ~ 5ml glycerine；Remaining is deionized water.
- 3. wound disinfection agent according to claim 1, it is characterised in that：Using the wound disinfection agent overall volume as 100ml is counted, wherein each component and its content that include are as follows：1g lysozyme chloride；0.05g Chlorhexidine；2g chitosan；0.3g tranexamic acid；2g carboxymethyl cellulose；3ml glycerine；Remaining is deionized water.
- 4. wound disinfection agent according to claim 1, it is characterised in that：Using the wound disinfection agent overall volume as 100ml is counted, wherein each component and its content that include are as follows：1.5g lysozyme chloride；0.07g Chlorhexidine；5g chitosan；0.4g tranexamic acid；3.5g carboxymethyl cellulose；4ml glycerine；Remaining is deionized water.
- 5. wound disinfection agent according to claim 1, it is characterised in that：Using the wound disinfection agent overall volume as 100ml is counted, wherein each component and its content that include are as follows：2g lysozyme chloride；0.1g Chlorhexidine；3g chitosan；0.5g tranexamic acid；5g carboxymethyl cellulose；5ml glycerine；Remaining is deionized water.
- 6. the method that one kind prepares the wound disinfection agent as described in claim 1 ~ 5 is any, it is characterised in that：Including following step Suddenly：A, 50ml deionized waters are taken, chitosan, Chlorhexidine, the tranexamic acid dissolving of precise is then added, obtains solution A；B, 30ml deionized waters are taken, lysozyme chloride, the carboxymethyl cellulose dissolving of precise is then added, obtains B solution；C, the glycerine accurately measured is added after being stirred B solution and solution A, deionized water is added after stirring to complete 100ml constant volumes are measured, filters, dispense through miillpore filter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610692608.4A CN107753937A (en) | 2016-08-19 | 2016-08-19 | A kind of wound disinfection agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610692608.4A CN107753937A (en) | 2016-08-19 | 2016-08-19 | A kind of wound disinfection agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753937A true CN107753937A (en) | 2018-03-06 |
Family
ID=61263265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610692608.4A Pending CN107753937A (en) | 2016-08-19 | 2016-08-19 | A kind of wound disinfection agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107753937A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481671A (en) * | 2018-12-11 | 2019-03-19 | 重庆灵方生物技术有限公司 | A kind of thimerosal and preparation method thereof |
| CN111760018A (en) * | 2020-06-11 | 2020-10-13 | 江苏开源康达医疗器械有限公司 | Efficient antibacterial and anti-inflammatory biological polysaccharide flushing fluid and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724079A (en) * | 2005-07-05 | 2006-01-25 | 中国人民解放军第三军医大学野战外科研究所 | Biologic external application medicine for curing wound |
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
-
2016
- 2016-08-19 CN CN201610692608.4A patent/CN107753937A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724079A (en) * | 2005-07-05 | 2006-01-25 | 中国人民解放军第三军医大学野战外科研究所 | Biologic external application medicine for curing wound |
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 傅宏义: "《常用药物分册》", 31 December 2005, 中国医药科技出版社 * |
| 卢小菊等: "溶菌酶与壳聚糖复配液抑菌作用的研究", 《中国食品添加剂》 * |
| 王丽丹: "壳聚糖复配体系及其抗菌性研究", 《道客巴巴》 * |
| 王向东等: "《发酵食品工艺》", 31 January 2011, 中国计量出版社 * |
| 高峰: "《药用高分子材料学》", 31 October 2014, 华东理工大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481671A (en) * | 2018-12-11 | 2019-03-19 | 重庆灵方生物技术有限公司 | A kind of thimerosal and preparation method thereof |
| CN111760018A (en) * | 2020-06-11 | 2020-10-13 | 江苏开源康达医疗器械有限公司 | Efficient antibacterial and anti-inflammatory biological polysaccharide flushing fluid and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105012993B (en) | A kind of cation Medical Living Creature Gum antiseptic dressing and preparation method thereof | |
| JP3981151B2 (en) | Composition for inactivating stimulants in a liquid | |
| TW200900004A (en) | Disinfectant | |
| US20120316129A1 (en) | Liquid dressing containing chitosan derivative and preparation method thereof | |
| CN108187132A (en) | A kind of povidone iodine hydrogel antiseptic dressing and preparation method thereof | |
| TW201505639A (en) | Antimicrobial compositions and methods of making the same | |
| CN109316536A (en) | A kind of skin mucosa disinfecting agent and preparation method thereof | |
| CN105031609B (en) | The disinfectant and its preparation and use of the Cbf-14 containing antibacterial peptide | |
| CN102387793A (en) | Antiseptic compositions comprising silver ions and menthol and uses thereof | |
| CN110072532A (en) | The agent of moisturizing partly sterilised | |
| CN105169408B (en) | A kind of sodium alginate antimicrobial spray and preparation method thereof | |
| CN102335452A (en) | Formula of functional dressing and preparation method thereof | |
| BR112020014234A2 (en) | COMPOSITIONS, KITS, METHODS AND USES FOR CLEANING, DISINFECTION, STERILIZATION AND / OR TREATMENT | |
| CN105169455B (en) | A kind of burn and scald external application first aid medical dressing and preparation method thereof | |
| ES2423730T3 (en) | Use of a synergistic composition as a therapeutic agent or disinfection agent | |
| CN107753937A (en) | A kind of wound disinfection agent and preparation method thereof | |
| CN111991417A (en) | Hypochlorous acid gel with physiological responsiveness and application thereof in skin wound surface | |
| CN110198731B (en) | Antimicrobial composition comprising sodium dimercaptopropane sulfonate and dimethyl sulfoxide, use of the composition, and wound treatment methods using the same | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN107753489B (en) | Beriberi treating preparation and its preparation method | |
| CN102961331A (en) | Iodine-chitosan solution formula and preparation method thereof | |
| JPH07502518A (en) | wound disinfectant | |
| KR20060103817A (en) | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol | |
| Yan et al. | Treatment and research of skin healthcare based on nanosilver ion material technology | |
| CN107595819A (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180306 |