CN105169408B - A kind of sodium alginate antimicrobial spray and preparation method thereof - Google Patents
A kind of sodium alginate antimicrobial spray and preparation method thereof Download PDFInfo
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- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 89
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 87
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 87
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 87
- 239000007921 spray Substances 0.000 title claims abstract description 68
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 66
- 235000011187 glycerol Nutrition 0.000 claims abstract description 33
- 239000008213 purified water Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 24
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 24
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 24
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 24
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 24
- 239000011719 vitamin A Substances 0.000 claims abstract description 24
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 24
- 239000011720 vitamin B Substances 0.000 claims abstract description 24
- 229940045997 vitamin a Drugs 0.000 claims abstract description 24
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 22
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229940116229 borneol Drugs 0.000 claims abstract description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 22
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 18
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
- 239000004332 silver Substances 0.000 claims description 6
- 229910052709 silver Inorganic materials 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 5
- 239000000908 ammonium hydroxide Substances 0.000 claims description 5
- 230000005855 radiation Effects 0.000 claims description 5
- 235000009508 confectionery Nutrition 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 19
- 230000035876 healing Effects 0.000 abstract description 9
- 230000000025 haemostatic effect Effects 0.000 abstract description 7
- 230000002503 metabolic effect Effects 0.000 abstract description 5
- 239000000243 solution Substances 0.000 description 32
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- 244000052616 bacterial pathogen Species 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000011259 mixed solution Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 206010042566 Superinfection Diseases 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
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Abstract
The invention belongs to medical spray fields, and in particular to a kind of sodium alginate antimicrobial spray and preparation method thereof.Sodium alginate antimicrobial spray is counted in parts by weight to be made of following component：0.1 ~ 0.8 part of sodium alginate, 1 ~ 6 part of antiseptic, 0.5 ~ 5 part of medical glycerine, 0.05 ~ 0.2 part of borneol, 0.5 ~ 2 part of vitamin A, 0.5 ~ 2 part of vitamin B, 95 ~ 100 parts of purified water.Sodium alginate antimicrobial spray provided by the invention can slow release antiseptic, durable antibacterial effect stablize, the resistance of skin can be improved, promote the metabolic capabilities of skin, accelerate the healing of wound, the healing environment of moistening can be provided to wound, while there is haemostatic effect.
Description
Technical field
The invention belongs to medical spray fields, and in particular to a kind of sodium alginate antimicrobial spray and preparation method thereof.
Background technology
Some wounds, scratch and pain caused by daily life need quickly to be alleviated and treated, Clinical practice
Drug be mostly paste, patient is very painful when medicine-feeding, and absorbs poor, and drug effect is difficult to play, while having very
The ointment taste of weight, and wound easy infection.
The treatment surface of a wound that occurs in the market relieves pain and the spray type of anti-inflammatory is fewer, and most of is that chitosan sprays
Agent or silver ion spray have no the antimicrobial spray containing alginate or sodium alginate.These sprays be substantially all in the presence of with
Lower problem：（1）The comparison of ingredients of spray is single, causes the function of spray relatively simple, lacks multi-functional spray；（2）It is anti-
Bacterium effect is than relatively limited, Shortcomings in terms of killing intractable pathogenic bacteria；（3）Most of product retention time over the course for the treatment of
It is shorter, greatly reduce the performance of product function；（4）Spray with antibacterial functions, with the increase of resting period, product
Stability declines.（5）Most of antiseptic is extracted from plant, and there are impurity content height, residual harmful substances etc.
Risk.
Invention content
Technical problem to be solved by the invention is to provide a kind of sodium alginate antimicrobial sprays and preparation method thereof, use this
Antimicrobial spray prepared by method can slow release antiseptic, durable antibacterial effect stablizes, can be improved the resistance of skin, promote skin
The metabolic capabilities of skin accelerate the healing of wound, and film-formation result is good, can be quickly formed in the surface of a wound and therapentic part surface layer
One layer of soft transparent membrane, can make spray permanence in wound repairing and therapentic part, play a role, and can be carried to wound
For the healing environment of moistening, while there is haemostatic effect.
Sodium alginate can be crosslinked with antibacterial material and be reacted in antimicrobial spray of the present invention, and antiseptic is coated on seaweed
In the reticular structure of sour sodium, antiseptic can be made slowly to release when in use, the antibacterial with lasting stability is imitated
Fruit.Addition borneol, vitamin A, vitamin B and medical glycerine are assisted simultaneously, plays the resistance for improving skin jointly, are promoted
The metabolic capabilities of skin are placed for a long time, can be provided moistening, sterile healing environment to wound, are conducive to wound healing,
There is haemostatic effect simultaneously.And borneol also has disinfection, while there is cool feeling, wound circumference temperature is reduced, pain is reduced
With cusalgia sense, glycerine then can moisturizing, extend the action time of sodium alginate antimicrobial spray, in addition the hydraulicity of sodium alginate,
After being sprayed onto on wound, layer protecting film can be formed, prevents external superinfection.
Technical scheme is as follows：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：
0.1 ~ 0.8 part of sodium alginate；
1 ~ 6 part of antiseptic；
0.5 ~ 5 part of medical glycerine；
0.05 ~ 0.2 part of borneol；
0.5 ~ 2 part of vitamin A；
0.5 ~ 2 part of vitamin B；
95 ~ 100 parts of purified water.
Preferably, the sodium alginate is high G/M, wherein G/M=10：5~11：The alginates of 2, high G/M have good
Haemostatic effect.
Preferably, the purity of the sodium alginate is 100%, is natural bioactive substance, can be degraded suction in human body
It receives, promotes the healing of wound.
Preferably, the antiseptic is colourless complex state Nano silver solution, which is that highly stable complex state is received
The silver-colored solution of rice, has good sterilizing ability, and placing will not change colour for a long time, not oxidized, have chromophoric monomer nanometer than common
Silver-colored solution or ionic state Nano silver solution antibiotic property are tens times strong, and have rapid sterilizing function；
Further, content of nanometer silver is the ppm of 1000 ppm ~ 3000, grain size in the colourless complex state Nano silver solution
Ranging from 1 ~ 10 nm；The particle size range of nano silver is controlled, can preferably react with being crosslinked in sodium alginate, be wrapped up
In the reticular structure of sodium alginate, achieve the effect that slow release.
Preferably, the purity of the medical glycerine is more than 99.8%, and the glycerine of high-purity not only can be with moisturizing, but also can play
Extend the action time of sodium alginate spray..
A kind of preparation method of sodium alginate antimicrobial spray, the preparation method specific process step are as follows：
S1. antiseptic is added in purified water, 2 ~ 5 min is mixed, add borneol, stir 2 ~ 5 min, dissolving
After mixing, sodium alginate is added, is mixed and stirred for the h of 0.5 h ~ 1 to uniform, it is spare；
S2. vitamin A, vitamin B, medical glycerine and purified water are taken, is first dissolved vitamin B with purified water, then with doctor
Vitamin A is dissolved with glycerine, 5 ~ 8 min are stirred after the two is mixed to uniform, it is spare；
S3. solution made from solution made from S1 and S2 is mixed, and stirs 10 ~ 20 min to uniform, adjusted with ammonium hydroxide
Then the pH value of mixed solution is sub-packed in spray bottle to 5.5 ~ 6.5, the sodium alginate antibacterial spray is obtained after radiation sterilization
Agent.
Further, each material composition content is counted in parts by weight in described step S1, S2, S3：Sodium alginate 0.1 ~ 0.8
Part, 1 ~ 6 part of antiseptic, 0.5 ~ 5 part of medical glycerine, 0.05 ~ 0.2 part of borneol, 0.5 ~ 2 part of vitamin A, 0.5 ~ 2 part of vitamin B,
95 ~ 100 parts of purified water.
Preferably, the sodium alginate is high G/M sodium alginates, G/M=10:5~11:2.
Preferably, the antiseptic is colourless complex state Nano silver solution, and content of nanometer silver is 1000 ppm ~ 3000
Ppm, particle size range are 1 ~ 10 nm；The purity of the medical glycerine is more than 99.8%.
Beneficial effects of the present invention are：（1）The present invention is using the sodium in sodium alginate in the antimicrobial spray of this method preparation
Ion can be crosslinked with antibacterial material to react, and antiseptic is coated in the reticular structure of sodium alginate, can use
When, so that antiseptic is slowly released, its antibacterial time is made to increase；（2）Addition borneol, vitamin A, dimension are assisted simultaneously
Raw element B and medical glycerine, play the resistance for improving skin, promote the metabolic capabilities of skin, can be carried to wound jointly
For moistening, sterile healing environment, be conducive to wound healing, while there is good haemostatic effect；（3）Borneol also has disinfection
Effect, while having cool feeling, reduces wound circumference temperature, reduces pain and cusalgia sense, the glycerine of high-purity both can with moisturizing,
The action time for extending sodium alginate spray can be played again, in addition the hydraulicity of sodium alginate being capable of shape after being sprayed onto on wound
At layer protecting film, external superinfection is prevented.
Specific implementation mode
With reference to embodiment, the following further describes the technical solution of the present invention.
Embodiment 1
A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：0.1 part of sodium alginate, colourless network
Close 1 part of state Nano silver solution, 0.5 part of medical glycerine, 0.05 part of borneol, 0.5 part of vitamin A, 0.5 part of vitamin B, purified water
100 parts.The sodium alginate is high G/M, and wherein G/M is 10:5~11:2, the purity of sodium alginate is 100%, colourless complex state
Content of nanometer silver is the ppm of 1000 ppm ~ 3000 in Nano silver solution, and particle size range is 1 ~ 10 nm, and the purity of medical glycerine is big
In 99.8%.
A kind of preparation method of sodium alginate antimicrobial spray, the preparation method specific process step are as follows：
S1. colourless complex state Nano silver solution is added in purified water, 2 ~ 5 min is mixed, adds borneol, stirs
Mix 2 ~ 5 min, dissolving after mixing, adds sodium alginate, is mixed and stirred for the h of 0.5 h ~ 1 to uniform, spare；
S2. vitamin A, vitamin B, medical glycerine and purified water are taken, is first dissolved vitamin B with purified water, then with doctor
Vitamin A is dissolved with glycerine, 5 ~ 8 min are stirred after the two is mixed to uniform, it is spare；
S3. solution made from solution made from S1 and S2 is mixed, and stirs 10 ~ 20 min to uniform, adjusted with ammonium hydroxide
Then the pH value of mixed solution is sub-packed in spray bottle to 5.5 ~ 6.5, the sodium alginate antibacterial spray is obtained after radiation sterilization
Agent.
Embodiment 2
A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：0.4 part of sodium alginate, colourless network
Close 3 parts of state Nano silver solution, 2.5 parts of medical glycerine, 0.1 part of borneol, 1 part of vitamin A, 1 part of vitamin B, purified water 100
Part.The sodium alginate is high G/M, and wherein G/M is 10:5~11:2, the purity of sodium alginate is 100%, colourless complex state nanometer
Content of nanometer silver is the ppm of 1000 ppm ~ 3000 in silver-colored solution, and particle size range is 1 ~ 10 nm, and the purity of medical glycerine is more than
99.8%。
A kind of preparation method of sodium alginate antimicrobial spray, the preparation method specific process step are as follows：
S1. colourless complex state Nano silver solution is added in purified water, 2 ~ 5 min is mixed, adds borneol, stirs
Mix 2 ~ 5 min, dissolving after mixing, adds sodium alginate, is mixed and stirred for the h of 0.5 h ~ 1 to uniform, spare；
S2. vitamin A, vitamin B, medical glycerine and purified water are taken, is first dissolved vitamin B with purified water, then with doctor
Vitamin A is dissolved with glycerine, 5 ~ 8 min are stirred after the two is mixed to uniform, it is spare；
S3. solution made from solution made from S1 and S2 is mixed, and stirs 10 ~ 20 min to uniform, adjusted with ammonium hydroxide
Then the pH value of mixed solution is sub-packed in spray bottle to 5.5 ~ 6.5, the sodium alginate antibacterial spray is obtained after radiation sterilization
Agent.
Embodiment 3
A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：0.8 part of sodium alginate, colourless network
Close 6 parts of state Nano silver solution, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, 100 parts of purified water.
The sodium alginate is high G/M, and wherein G/M is 10:5~11:2, the purity of sodium alginate is 100%, colourless complex state nano silver
Content of nanometer silver is the ppm of 1000 ppm ~ 3000 in solution, and particle size range is 1 ~ 10 nm, and the purity of medical glycerine is more than
99.8%。
A kind of preparation method of sodium alginate antimicrobial spray, the preparation method specific process step are as follows：
S1. colourless complex state Nano silver solution is added in purified water, 2 ~ 5 min is mixed, adds borneol, stirs
Mix 2 ~ 5 min, dissolving after mixing, adds sodium alginate, is mixed and stirred for the h of 0.5 h ~ 1 to uniform, spare；
S2. vitamin A, vitamin B, medical glycerine and purified water are taken, is first dissolved vitamin B with purified water, then with doctor
Vitamin A is dissolved with glycerine, 5 ~ 8 min are stirred after the two is mixed to uniform, it is spare；
S3. solution made from solution made from S1 and S2 is mixed, and stirs 10 ~ 20 min to uniform, adjusted with ammonium hydroxide
Then the pH value of mixed solution is sub-packed in spray bottle to 5.5 ~ 6.5, the sodium alginate antibacterial spray is obtained after radiation sterilization
Agent.
It is anti-to sodium alginate of the present invention to verify whether sodium alginate antimicrobial spray of the present invention reaches expected invention effect
Bacterium spray carries out antibacterial tests and animal experiment analysis, as a result as follows：
It includes staphylococcus aureus, Candida albicans, withered grass to lead to some of gynaecology and infected wound pathogenic bacteria mainly
Bacillus, coliform, Pseudomonas aeruginosa, hemolytic streptococcus etc., this experiment is with 1 ~ 3 sea of above-mentioned pathogenic bacteria testing example
The antibacterial effect of mosanom antimicrobial spray.As can be seen from the above table, the sodium alginate antimicrobial spray that prepared by the present invention is to major part
Pathogenic bacteria have good antibacterial effect, while having good haemostatic effect, biocompatibility, and safety non-toxic, can be with
Safe handling, can improve the resistance of skin, promote the metabolic capabilities of skin, can be provided to wound and moisten, is sterile
Healing environment, promote the healing of wound.
Embodiment 4
It is better than the antiseptic of other forms to verify sodium alginate antimicrobial spray of the present invention in terms of stability, antibiotic property,
The present invention is tested as follows.
Experimental group：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：0.5 part of sodium alginate,
4 parts of colourless complex state Nano silver solution, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, purified water
100 parts.
Control group 1：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：Sodium alginate 0.5
Part, 4 parts of silver nitrate solution, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, 100 parts of purified water.
Control group 2：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：Sodium alginate 0.5
Part, 4 parts of coloured monomer nano silver solution, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, purified water
100 parts.
Control group 3：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：Sodium alginate 0.5
Part, 4 parts of ionic state Nano silver solution, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, purified water
100 parts.
Antibacterial tests analysis is carried out to experimental group and each control group, as a result as follows：
As can be seen from the above table, the sodium alginate antimicrobial spray that prepared by the present invention has the antibacterial effect of lasting stability.It is logical
Contrast experiment's group and control group are crossed it can be found that the sodium alginate antimicrobial spray for the antiseptic preparation that the preparation method uses is to big
The antibacterial effect of part pathogenic bacteria is better than antimicrobial spray prepared by other form antiseptics.
Embodiment 5
For the synergistic effect for verifying between sodium alginate antimicrobial spray each component of the present invention, the present invention is tested as follows.
Experimental group：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：0.5 part of sodium alginate,
Wherein G/M=11 in sodium alginate:2,4 parts of colourless complex state Nano silver solution, 5 parts of medical glycerine, 0.5 part of borneol, vitamin A
2 parts, 2 parts of vitamin B, 100 parts of purified water.
Control group 1：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：Sodium alginate 0.5
Part, wherein G/M=7 in sodium alginate:5,4 parts of colourless complex state Nano silver solution, 5 parts of medical glycerine, 0.2 part of borneol, vitamin
2 parts of A, 2 parts of vitamin B, 100 parts of purified water.
Control group 2：A kind of sodium alginate antimicrobial spray, counts be made of following component in parts by weight：Colourless complex state is received
Silver-colored 4 parts of the solution of rice, 5 parts of medical glycerine, 0.2 part of borneol, 2 parts of vitamin A, 2 parts of vitamin B, 100 parts of purified water.
By above-mentioned test result can be seen that the sodium alginate antimicrobial spray for preparing of the present invention have hemostasis well,
Film-formation result, wound healing is fast, good anti-bacterial effect；By contrast experiment's group and control group 1 it can be found that the sodium alginate antibacterial
The sodium alginate of high G/M contents has the effect of better haemostatic effect and promotes wound healing in spray.Pass through contrast experiment
Group and control group 2 it can be found that in the sodium alginate antimicrobial spray sodium alginate presence, be conducive to improve Nano silver solution
Anti-microbial property, while the film forming of sodium alginate antimicrobial spray depends on the film forming of sodium alginate.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention；For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways, there is no necessity and possibility to exhaust all the enbodiments；It is all this
All any modification, equivalent and improvement etc., should be included in the claims in the present invention made by within the spirit and principle of invention
Protection domain within.
Claims (5)
1. a kind of sodium alginate antimicrobial spray, which is characterized in that count be made of following component in parts by weight：
The sodium alginate is high G/M sodium alginates, G/M=10:5~11:2；
The antiseptic is colourless complex state Nano silver solution.
2. a kind of sodium alginate antimicrobial spray according to claim 1, which is characterized in that the purity of the sodium alginate is
100%.
3. a kind of sodium alginate antimicrobial spray according to claim 1, which is characterized in that the colourless complex state nano silver
Content of nanometer silver is 1000ppm~3000ppm in solution, and particle size range is 1~10nm.
4. a kind of sodium alginate antimicrobial spray according to claim 1, which is characterized in that the purity of the medical glycerine
More than 99.8%.
5. a kind of preparation method of sodium alginate antimicrobial spray according to claim 1, which is characterized in that the preparation side
Method specific process step is as follows：
S1. antiseptic is added in purified water, 2~5min is mixed, add borneol, stir 2~5min, dissolving mixing is equal
After even, sodium alginate is added, is mixed and stirred for 0.5h~1h to uniform, it is spare；
S2. vitamin A, vitamin B, medical glycerine and purified water are taken, is first dissolved vitamin B with purified water, then with medical sweet
Oil dissolves vitamin A, 5~8min is stirred after the two is mixed to uniform, spare；
S3. solution made from solution made from S1 and S2 is mixed, and stirs 10~20min to uniform, adjusted and mixed with ammonium hydroxide
Then the pH value of solution is sub-packed in spray bottle to 5.5~6.5, the sodium alginate antimicrobial spray is obtained after radiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN106491642A (en) * | 2016-11-18 | 2017-03-15 | 无锡明盛纺织机械有限公司 | A kind of sodium alginate antimicrobial spray and preparation method thereof |
| CN107899003B (en) * | 2017-10-20 | 2021-08-06 | 湖北中创医疗用品有限公司 | Chitosan oligosaccharide medical wound care membrane and preparation method thereof |
| CN108743702A (en) * | 2018-06-09 | 2018-11-06 | 江苏海尔滋生物科技有限公司 | A kind of anti-haze poison spray and preparation method thereof |
| CN109381449A (en) * | 2018-10-24 | 2019-02-26 | 广西信业生物技术有限公司 | A kind of dermatitis antibacterial film forming spray and preparation method thereof |
| CN110812328A (en) * | 2019-11-27 | 2020-02-21 | 苏州汇涵医用科技发展有限公司 | Pet spray dressing and preparation method thereof |
| CN111110628A (en) * | 2020-02-12 | 2020-05-08 | 药肽医学研究(济南)有限公司 | Sterilization disinfectant and preparation method thereof |
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| CN102091345A (en) * | 2010-12-28 | 2011-06-15 | 中国人民解放军军事医学科学院野战输血研究所 | Sodium alga acid composition and application thereof |
| CN104323992A (en) * | 2014-11-09 | 2015-02-04 | 常州迪力卫生材料有限公司 | Sodium alginate spray and production process thereof |
| CN104623722A (en) * | 2015-02-13 | 2015-05-20 | 青岛明月生物医用材料有限公司 | Alginic acid antibacterial hemostatic sponge material and preparation method thereof |
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| US6696077B2 (en) * | 2001-07-26 | 2004-02-24 | George H. Scherr | Silver alginate foam compositions |
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| CN102091345A (en) * | 2010-12-28 | 2011-06-15 | 中国人民解放军军事医学科学院野战输血研究所 | Sodium alga acid composition and application thereof |
| CN104323992A (en) * | 2014-11-09 | 2015-02-04 | 常州迪力卫生材料有限公司 | Sodium alginate spray and production process thereof |
| CN104623722A (en) * | 2015-02-13 | 2015-05-20 | 青岛明月生物医用材料有限公司 | Alginic acid antibacterial hemostatic sponge material and preparation method thereof |
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| 高效络合银液态抗菌剂用于水刺非织造布后整理;顾永星;《产业用纺织品 功能性整理技术与助剂》;20111231(第8期);第38,39,43页 * |
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