CN104623722A - Alginic acid antibacterial hemostatic sponge material and preparation method thereof - Google Patents

Alginic acid antibacterial hemostatic sponge material and preparation method thereof Download PDF

Info

Publication number
CN104623722A
CN104623722A CN201510079829.XA CN201510079829A CN104623722A CN 104623722 A CN104623722 A CN 104623722A CN 201510079829 A CN201510079829 A CN 201510079829A CN 104623722 A CN104623722 A CN 104623722A
Authority
CN
China
Prior art keywords
alginic acid
sponge material
silver
wound
antibacterial agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201510079829.XA
Other languages
Chinese (zh)
Other versions
CN104623722B (en
Inventor
邓云龙
郝玉娜
邵建华
张妮
秦益民
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QINGDAO BRIGHT MOON BIOMEDICAL MATERIAL CO Ltd
Original Assignee
QINGDAO BRIGHT MOON BIOMEDICAL MATERIAL CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QINGDAO BRIGHT MOON BIOMEDICAL MATERIAL CO Ltd filed Critical QINGDAO BRIGHT MOON BIOMEDICAL MATERIAL CO Ltd
Priority to CN201510079829.XA priority Critical patent/CN104623722B/en
Publication of CN104623722A publication Critical patent/CN104623722A/en
Application granted granted Critical
Publication of CN104623722B publication Critical patent/CN104623722B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Materials For Medical Uses (AREA)

Abstract

The invention discloses an alginic acid antibacterial hemostatic sponge material which is suitable for being applied to wound dressing and a preparation method for the alginic acid antibacterial hemostatic sponge material. The preparation method comprises the following steps: uniformly dispersing alginic acid fibers which are cut into a certain length and a sliver-containing antibacterial agent into a sodium alginate aqueous solution, wherein the sodium alginate aqueous solution is cross-linked by positive ions combined on the fibers to form a stable porous sponge structure, and the sliver-containing antibacterial agent is uniformly distributed on the surface and inside the porous sponge structure. The alginic acid antibacterial hemostatic sponge material has excellent performances while being applied to the wound dressing. The porous sponge structure has strong moisture absorption performance, and can be used for greatly absorbing wound percolate to form gel, so that a wet environment is provided for the wound to promote the wound to heal; sliver-containing antibacterial dressing can be added to prevent the wound from bacterial infection, so that adhesion is not produced to the wound, and secondary injuries are not caused to the wound.

Description

A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method
Technical field
The invention belongs to medical sponge dressing field, be specifically related to a kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method.
Background technology
Along with the aging of world population, the disease relevant to old people and their improvement are becoming more and more important.The elderly's activity is few, and the incidence rate of the chronic ulcerative such as decubital ulcer, pressure ulcer wound is high.Because the transudate of exedens wound is many, healing cycle is long, take cotton cloth as the needs that the conventional medical dressing of representative is difficult to meet nursing process.High-tech medical dressing, by the high efficiency of the high efficiency of material, the high-effect of product and nursing process, greatly can improve the nursing process of wound.
Moistening substrate to be moved and propagation has facilitation epithelial gushing, and be conducive to the healing promoting wound, it is theoretical that this theory is called as " Soaking therapy ".Along with " Soaking therapy " theoretical popularizing, new type functional medical dressing based on " Soaking therapy " gets more and more, and calcium alginate fibre, polyurethane film and foam, hydrocolloid, hydrogel, carboxymethyl cellulose etc. all obtain extensively medical based on this theory in the production of functional medical dressing.These novel medical dressing cover after on wound surface, and all or part of of wound fluid is maintained in the structure of dressing, form a moistening microenvironment in wound surface.
Calcium alginate fibre and medical dressing thereof are a kind of typically based on the new type functional medical material of " wet method therapy ".Calcium ion in calcium alginate fibre and the sodium ion in human body carry out ion exchange, and part calcium alginate makes a large amount of moisture be inhaled in the structure of fiber after being converted into water miscible sodium alginate, wound is formed one deck water gel.This layer of colloid provides a moistening environment for wound surface, facilitates the agglutination of wound.
Though be that the medical dressing of raw material has good gel-forming property with calcium alginate fibre, gel is formed after absorptive tissue transudate, for wound provides moist environment, but its moisture pick-up properties is lower, general liquid absorption is 10-12 times of own wt, often need more change dressings when running into the wound having a large amount of transudate, and be unfavorable for the healing of wound, used by the nurse fees adding wound.Meanwhile, chronic ulcerative wound is subject to bacteriological infection, and the healing of antibiotic property to the chronic ulcerative such as decubital ulcer, pressure ulcer wound of therefore dressing has vital effect.
Summary of the invention
Technical problem to be solved by this invention is the performance improving alginic acid sthptic sponge, provides a kind of silver-containing alginic acid antibacterial anti hemorrhagic sponge with antibacterial action.
A kind of alginic acid antibacterial anti hemorrhagic sponge material, be take water as carrier, its component and weight portion are: sodium alginate 10-40 part, calcium alginate short fiber 15-50 part, plasticizer glycerol 10-75 part, silver-containing antibacterial agent 0.1-1 part.
Further, the water content of described sponge material, lower than 50%, is calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol, silver-containing antibacterial agent and water.
Further, the water content of described sponge material, lower than 20%, is calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol, silver-containing antibacterial agent and water.
Further, the gross mass mark of described sodium alginate and calcium alginate short fiber is 40-60%, calculates with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
Further, the mass fraction of described plasticizer glycerol is 60-40%, calculates with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
Further, the mass fraction of described silver-containing antibacterial agent is 500-1000ppm, calculates with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
Preferably, a kind of alginic acid antibacterial anti hemorrhagic sponge material, be take water as carrier, its component and percentage by weight are: sodium alginate 17%, calcium alginate short fiber 41%, plasticizer glycerol 41%, silver-containing antibacterial agent 1%.
Further, described silver-containing antibacterial agent is the sodium zirconium phosphate compound of silver.
Further, described calcium alginate fibre selects length to be the short fiber of 3-5mm.
The preparation method of a kind of alginic acid antibacterial anti hemorrhagic sponge material provided by the invention, take water as carrier, be dissolved in the water the sodium alginate of formula ratio and glycerol formation homogeneous solution respectively, by the silver-containing antibacterial agent of formula ratio and calcium alginate fibre formation homogeneous solution soluble in water, spread out freezing after above-mentioned aqueous solution is stirred in a reservoir, obtain alginic acid antibacterial anti hemorrhagic sponge through lyophilization.
Compared with prior art, advantage of the present invention and good effect are: alginic acid antibacterial anti hemorrhagic sponge of the present invention has the biological activity of alginic acid, simultaneously because the existence of silver ion has stronger antibiotic property.The loose structure formed in freezing dry process, makes it have very high hygroscopicity, is retained in sponge structure by moisture simultaneously, for wound provides a moist environment promoting its healing.Sponge can with the sodium ion exchange in transudate simultaneously, release calcium ion, and the calcium ion discharged can activate by induced platelet, produces thrombin and somatomedin, has the effect of hemostasis and healing acceleration.The existence of silver-containing antibacterial agent improves the antibiotic property of sponge, can prevent bacterial wound infection.
The medical dressing using alginic acid antibacterial anti hemorrhagic sponge of the present invention to make has very high hygroscopicity, antibiotic property and safety in utilization, when being applied to chronic ulcerative wound, can play the effect absorbing pus and blood in a large number, prevent wound infection and Promotive union.
Accompanying drawing explanation
The structural representation of Fig. 1 alginic acid antibacterial anti hemorrhagic sponge;
Wherein, 1, calcium alginate short fiber; 2, small hole; 3, alginic acid polymer; 4, silver-containing antibacterial agent.
Detailed description of the invention
A kind of alginic acid antibacterial anti hemorrhagic sponge material of the present invention, is take water as carrier, also comprises following component: sodium alginate 10-40 part, calcium alginate short fiber 15-50 part, plasticizer glycerol 10-75 part, silver-containing antibacterial agent 0.1-1 part, be more than weight portion.Preferred percentage by weight formula is sodium alginate 17%, calcium alginate short fiber 41%, plasticizer glycerol 41%, silver-containing antibacterial agent 1%.
The water content of described manufactured goods sponge material, lower than 50%, preferably lower than 20%, is calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol, silver-containing antibacterial agent and pure water.Alginic acid antibacterial anti hemorrhagic sponge material water content of the present invention is lower, and the hygroscopicity of sponge material is higher, can abundant absorptive tissue transudate when being used in wound, and is conducive to the long-term preservation of sponge material.
The polymer of calcium alginate short fiber and sodium alginate is included in described sponge material, calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent, the gross mass mark of described sodium alginate and calcium alginate short fiber is 40-60%, make sponge material while having compared with high-hygroscopicity, the gel strength formed after gel is also higher, and has excellent outward appearance; The mass fraction of described plasticizer glycerol is 60-40%; The mass fraction of described silver-containing antibacterial agent is 500-1000ppm.
Described silver-containing antibacterial agent is the sodium zirconium phosphate compound of silver.The sodium zirconium phosphate compound of described silver has good chemical stability, and safety is high, the color of sponge material will be caused to change because of Oxidation, make sponge material steady quality of the present invention.
Described calcium alginate fibre selects length to be the short fiber of 3-5mm.Described calcium alginate short fiber discharges Ca in sponge material manufacturing process 2+, Ca 2+main Function be cross-linking agent; After sponge material molding, not consoluet short fiber is evenly distributed in sponge material, first skeleton function is played, be conducive to improving the intensity of sponge material and keeping the stability of sponge material structure, and be conducive to the gel strength after improving plastic, meanwhile, after sponge material absorptive tissue transudate, by discharging calcium ion with the ion exchange of sodium ion in transudate, be conducive to promoting wound healing.
The preparation method of a kind of alginic acid antibacterial anti hemorrhagic sponge material of the present invention, concrete steps are:
1), prepare burden: take sodium alginate, calcium alginate short fiber, glycerol and silver-containing antibacterial agent by proportioning;
2), by sodium alginate make powder, join in pure water, stirring and dissolving obtains sodium alginate aqueous solution;
3), by glycerol join in pure water, stir and make its uniform dissolution in pure water;
4), by calcium alginate fibre cut into the short fiber that length is 3-5mm, and be distributed to uniformly in pure water;
5), by silver-containing antibacterial agent join in pure water, fully stir, make silver-containing antibacterial agent be uniformly distributed in pure water;
6), glycerine water solution and silver-containing antibacterial agent aqueous solution are joined in sodium alginate aqueous solution, fully stir, make its mix homogeneously;
7), the calcium alginate short fiber be uniformly distributed in pure water is joined in the mixed solution of step 6, fully stir 10-20min;
8) mixed solution, step 7 obtained injects mould, mould is put into refrigerator freezing indoor after surfacing and carry out freezing 8-12h, cryogenic temperature is about-20 DEG C, freezing complete after mould is put into freezer dryer, lyophilization is carried out under the condition of-55 DEG C, obtain the alginic acid antibacterial anti hemorrhagic sponge material with loose structure after lyophilization completes, after cutting out packaging and sterilizing, can be applicable to medical sponge dressing.
In preparation process, after each component mixes with pure water, the quality sum of sodium alginate, calcium alginate short fiber, glycerol and silver-containing antibacterial agent is less than 5% of mixed liquor gross mass, to ensure that the water content of manufactured goods sponge material is lower than 50%.
Calcium ion in described calcium alginate fibre, as cross-linking agent, can form gel by crossslinked sodium alginate aqueous solution, form a large amount of uniform small hole, silver-containing antibacterial agent is fixed in sponge structure in freezing dry process.With by spraying etc. compared with silver dressings prepared by method, argentiferous sponge material prepared by this patent has higher safety and more excellent anti-microbial property.By the methods such as spraying prepare the silver-containing antibacterial agent of dressing mainly concentrate on dressing surface, when being applied to wound, easily causing local silver-containing antibacterial constituent concentration too high, produce cytotoxicity.Silver-containing antibacterial agent in argentiferous sponge material prepared by the present invention is fixed in sponge material uniformly, after sponge material absorbing wound exudate forms gel, silver-containing antibacterial composition discharges to wound slowly, make the antibacterial action persistent period of sponge material long, effect is better, and make the silver-containing antibacterial composition in wound maintain in safe concentration range, the replacement frequency of dressing can be reduced, reduce wound care expense.
Embodiment 1:
1. accurately take sodium alginate 1g, join in 100g water, fully stir and form homogeneous solution;
2. accurately take glycerol 2.5g, join in 50g water, fully stir and form homogeneous solution;
3. accurately take calcium alginate fibre 2.5g, cut into the short fiber that length is 4mm, join in 250g water, fully stir, make fiber be dispersed in water;
4. accurately take the sodium zirconium phosphate compound 0.06g of silver, join in 100g water, fully stir, make argentiferous sodium zirconium phosphate compound be dispersed in water, form suspension;
5. four kinds of different solutions mixing step 1., 2., 3., 4. obtained, stir 10min;
6. above-mentioned mixed solution being poured into diameter is in the flat material disc of rustless steel of 180mm, ensures solution surfacing in material disc, and thickness is even, then puts into refrigerator freezing indoor fully freezing;
7. by step 6. in sufficiently chilled material disc transfer in vacuum freeze drier, vacuum lyophilization 48h, after lyophilization completes silver-containing alginic acid sponge sample.
Gained sponge sample through cutting into the lamellar of the different size such as 5 × 5cm or 10 × 10cm, can use as medical dressing, and being sample 1 by sample label, facilitating follow-up test record after packaging sterilizing.
Embodiment 2-3:
Identical with the experimental technique described in embodiment 1, feed change proportioning, prepares the sponge material that each constituent content is different, and carrying out label to obtained sponge sample is respectively sample 2 and sample 3.Proportioning raw materials is as shown in the table.
Table 1 sponge material raw material ratio
Group number Sodium alginate (g) Calcium alginate short fiber (g) Glycerol (g) Sodium zirconium phosphate compound (g) of silver Total Water (g)
Sample 1 1 2.5 2.5 0.06 500
Sample 2 1.5 3 3 0.038 500
Sample 3 2.5 2.5 3 0.024 500
Embodiment 4:
The test of moisture pick-up properties has been carried out to the sponge sample obtained by embodiment 1-3.
Test solution uses A liquid, and A liquid is test the standard test liquid that alginic acid medical dressing moisture pick-up properties specifies in British Pharmacopoeia, and this solution simulates the content of calcium ion in wound fluid and sodium ion, by the CaCl containing 2.5mmol/L 22H 2the NaCl solution of O and 142mmol/L forms.A liquid is by 8.3gNaCl, 0.277gCaCl 2prepare after being diluted to 1L.
The method that method of testing is formulated for alginic acid medical dressing according to British Pharmacopoeia.Lyophilization sponge sample is cut into 5cm × 5cm size, and measuring its dry weight is W gram.Because lyophilization sponge sucks in water performance is comparatively strong, so sponge sample to be placed in the A liquid of its dry weight 60 times, under 37 DEG C of conditions, places 30min, measure its weight in wet base (w by after unsettled for the sponge sample after moisture absorption 30s 1).The then hygroscopicity=(W of Unit Weight sponge sample 1-W)/W gg -1, and the hygroscopicity=4 (W of unit are 1-W) g100cm -2.Moisture pick-up properties result is as shown in table 2.
The test result of table 2 moisture pick-up properties
As seen from the above table, sponge material of the present invention has stronger hygroscopicity, and liquid absorption can reach more than 24 times of own wt, can absorb a large amount of puss, is conducive to reducing nurse fees and uses.
Embodiment 5
Carry out quantitative disinfecting test to alginic acid antibacterial anti hemorrhagic sponge of the present invention, foundation is GB/T20944.3-2008 " evaluation the 3rd part of antibacterial textile performance: succusion ".
Sample 1,2 and 3: alginic acid antibacterial anti hemorrhagic sponge of the present invention;
Control sample: for testing growth of microorganism condition, 100% bafta without any process.
Sample 1,2,3 and control sample are cut into respectively the fragment of 5mm × 5mm size, take 0.75 ± 0.05g as a sample, wrap with the little scraps of paper, sterilizing is for subsequent use.
One, strain: escherichia coli, staphylococcus aureus
Two, method
1 culture medium and reagent:
Nutrient broth, nutrient agar, 0.03mol/LPBS (phosphate) buffer.
2 test methods
Bacterium liquid is carried out count plate by 2.1, and is mixed with bacteria containing amount is 2.5 × 10 with the dilution of PBS buffer 5cfu/mL-4 × 10 5the bacteria suspension of cfu/mL.
2.2 prepare 15 250ml conical flasks, sample 1 (0.75 ± 0.05g) is respectively added wherein in 3 flasks, sample 2 (0.75 ± 0.05g) is respectively added in 3 flasks, sample 3 (0.75 ± 0.05g) is respectively added in 3 flasks, respectively add control sample (0.75 ± 0.05g) in 3 flasks, another 3 flasks do not add sample as blank.Then in each flask, 70ml ± 0.01mlPBS buffer is respectively added.
Sample preparation 2.3 " 0 " times of contact: respectively add 5mL with suction pipe in 3 control sample flasks and 3 blank flasks and inoculate bacterium liquid.Build bottle stopper, 24 DEG C ± 1 DEG C, 250r/min-300r/min, vibration 1min ± 5s.
Sampling 2.4 " 0 " times of contact: respectively draw 1mL ± 0.1mL solution with suction pipe in 6 flasks of " 0 " sample preparation time of contact, moves into and is equipped with in the test tube of 9mL ± 0.1mL PBS buffer, fully mix.Carry out 1 dilution again with 10 times of dilution methods, fully mix.Draw 1mL ± 0.1mL on nutrient agar flat board (each 10 2the test tube of extension rate respectively imbibition makes two flat boards), cultivate 24h-48h for 37 DEG C ± 1 DEG C.Record the clump count in each flat board.
2.5 timing oscillating contact: respectively add 5mL with suction pipe in 3 sample 1 flasks, 3 sample 2 flasks and 3 sample 3 flasks and inoculate bacterium liquid, build bottle stopper.Again by 24 DEG C ± 1 DEG C, 15 flasks, 150r/min, vibration 18h.
The mensuration of 2.6 dilution cultivations and clump count: after the stipulated time, draw 1mL ± 0.1mL solution from each flask, move into and be equipped with in the test tube of 9mL ± 0.1mL PBS buffer, fully mix.Draw 1mL ± 0.1mL (test tube of each extension rate respectively imbibition makes two flat boards) on nutrient agar flat board with 10 times of dilution method serial dilutions to appropriate dilutions multiple, cultivate 24h-48h for 37 DEG C ± 1 DEG C.Record the clump count in each flat board.
The appropriate dilutions multiple of clump count between 30cfu-300cfu is selected to count.If the clump count < 30 in minimum extension rate flat board, then press actual quantity record; If without colony growth, then clump count is designated as < 1.
The clump count difference of two parallel flats should within 15%, otherwise this data invalid, test of should reforming.
The calculating of 2.7 results and evaluation
2.7.1 the judgement of test validity
The increasing value F of test organisms is calculated according to formula (1).To the antibacterial such as escherichia coli and staphylococcus aureus, when F is greater than 1.5, and when the viable bacteria concentration in blank increases than viable bacteria concentration during inoculation, test judges effectively.Otherwise invalidate the test, need re-start test.
F=lgW t-lgW 0……………………………(1)
The test organisms increasing value of F---control sample;
W t---the meansigma methods of the viable bacteria concentration after 3 control sample 18h oscillating contact in flask;
W 0---the meansigma methods of the viable bacteria concentration in 3 control sample " 0 " flasks time of contact.
2.7.2 the calculating of bacteriostasis rate
Y = W t - Q t W t &times; 100 % . . . ( 2 )
The bacteriostasis rate of Y---sample;
W t---the meansigma methods of the viable bacteria concentration after 3 control sample 18h oscillating contact in flask;
Q t---the meansigma methods of the viable bacteria concentration after 3 sample 18h oscillating contact in flask.
The expression of 2.8 results
With the value of calculation of bacteriostasis rate as a result.When bacteriostasis rate value of calculation is negative, be expressed as " 0 "; When bacteriostasis rate value of calculation >=0, be expressed as " >=0 ".
The evaluation of 2.9 antibacterial effects
To escherichia coli and staphylococcus aureus bacteriostasis rate >=70%, then alginic acid antibacterial anti hemorrhagic sponge has fungistatic effect.
Three, result
Can find out according to table 3, sponge material of the present invention is good to the Comparison of effect on sterilization of escherichia coli, staphylococcus aureus, and its sterilizing rate all reaches more than 99%.
Table 3 alginic acid antibacterial anti hemorrhagic sponge is to the bacteriostasis rate of different strain
The invention provides a kind of the alginic acid antibacterial anti hemorrhagic sponge and the preparation technology thereof that are applicable to wound dressing, the alginic acid antibacterial anti hemorrhagic sponge of being prepared by the present invention not only has the biological activity of alginic acid, also there is stronger absorbency, gel is formed after absorptive tissue transudate, for wound provides the moist environment being beneficial to and promoting its healing, there is the effect of hemostasis and promotion wound healing, the existence of silver-containing antibacterial agent simultaneously improves the antibiotic property of sthptic sponge, can prevent bacterial wound infection when being applied to wound.The alginic acid antibacterial anti hemorrhagic sponge of being prepared by the present invention is applicable to decubital ulcer, burn etc. more transudate and chronic ulcerative wound, has higher economic benefit and social benefit.
Above embodiment is only the one in the several preferred implementation of the present invention, it should be pointed out that and the invention is not restricted to above-described embodiment; For the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement is carried out to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.

Claims (10)

1. an alginic acid antibacterial anti hemorrhagic sponge material, is be carrier with water, it is characterized in that: its component and weight portion are: sodium alginate 10-40 part, calcium alginate short fiber 15-50 part, plasticizer glycerol 10-75 part, silver-containing antibacterial agent 0.1-1 part.
2. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, is characterized in that: the water content of described sponge material, lower than 50%, is calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol, silver-containing antibacterial agent and water.
3. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 2, is characterized in that: the water content of described sponge material, lower than 20%, is calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol, silver-containing antibacterial agent and water.
4. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, it is characterized in that: the gross mass mark of described sodium alginate and calcium alginate short fiber is 40-60%, calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
5. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 4, is characterized in that: the mass fraction of described plasticizer glycerol is 60-40%, calculates with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
6. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, it is characterized in that: the mass fraction of described silver-containing antibacterial agent is 500-1000ppm, calculate with the quality sum of sodium alginate, calcium alginate short fiber, plasticizer glycerol and silver-containing antibacterial agent.
7. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 5 or 6, is be carrier with water, it is characterized in that: its component and percentage by weight are: sodium alginate 17%, calcium alginate short fiber 41%, plasticizer glycerol 41%, silver-containing antibacterial agent 1%.
8. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, is characterized in that: described silver-containing antibacterial agent is the sodium zirconium phosphate compound of silver.
9. a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, is characterized in that: described calcium alginate fibre selects length to be the short fiber of 3-5mm.
10. the preparation method of a kind of alginic acid antibacterial anti hemorrhagic sponge material according to claim 1, it is characterized in that: be take water as carrier, be dissolved in the water the sodium alginate of formula ratio and glycerol formation homogeneous solution respectively, by the silver-containing antibacterial agent of formula ratio and calcium alginate fibre formation homogeneous solution soluble in water, spread out freezing after above-mentioned aqueous solution is stirred in a reservoir, obtain alginic acid antibacterial anti hemorrhagic sponge through lyophilization.
CN201510079829.XA 2015-02-13 2015-02-13 A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method Active CN104623722B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510079829.XA CN104623722B (en) 2015-02-13 2015-02-13 A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510079829.XA CN104623722B (en) 2015-02-13 2015-02-13 A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method

Publications (2)

Publication Number Publication Date
CN104623722A true CN104623722A (en) 2015-05-20
CN104623722B CN104623722B (en) 2017-03-15

Family

ID=53203268

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510079829.XA Active CN104623722B (en) 2015-02-13 2015-02-13 A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method

Country Status (1)

Country Link
CN (1) CN104623722B (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169408A (en) * 2015-10-13 2015-12-23 广东泰宝医疗科技股份有限公司 Sodium alginate antibiosis spray and preparation method thereof
CN105412981A (en) * 2015-12-29 2016-03-23 无锡恒成医疗科技股份有限公司 Medical alginate hydrogel, production technology and applications thereof
CN105497964A (en) * 2015-12-17 2016-04-20 青岛明月生物医用材料有限公司 Fucoidin-alginate sponge and preparation method thereof
CN105662713A (en) * 2015-12-29 2016-06-15 无锡恒成医疗科技股份有限公司 Medical dressing for treating large area wound and manufacturing method thereof
CN106579573A (en) * 2016-11-29 2017-04-26 东莞市广信知识产权服务有限公司 Long-acting antibacterial warm-keeping underwear and preparation method thereof
CN106723389A (en) * 2016-11-29 2017-05-31 东莞市广信知识产权服务有限公司 A kind of long-acting magnetotherapy thermal underwear and preparation method thereof
RU2627855C1 (en) * 2016-11-28 2017-08-14 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Hemostatic sponge (versions)
CN107261190A (en) * 2017-06-12 2017-10-20 北京化工大学常州先进材料研究院 A kind of gradient crosslinked type medical wound transparent dressing of sodium alginate/hydroxymethyl cellulose/gelatin interpenetrating networks and preparation method thereof
CN107456602A (en) * 2017-08-04 2017-12-12 北京化工大学常州先进材料研究院 A kind of medical aquogel body dressing of the short fine enhancing of full biodegradable and preparation method thereof
RU2639379C1 (en) * 2016-11-28 2017-12-21 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Hemostatic coating in form of sponge or film (versions)
CN108295298A (en) * 2018-01-25 2018-07-20 四川大学 A kind of calcium alginate perforated membrane of the basic zirconium phosphate containing carrying metal ion and preparation method thereof
CN109331215A (en) * 2018-11-01 2019-02-15 河南驼人贝斯特医疗器械有限公司 A kind of medical antibacterial sponge and preparation method thereof
CN112807477A (en) * 2020-12-30 2021-05-18 广州迈普再生医学科技股份有限公司 Composite hemostatic material and preparation method thereof
CN114259598A (en) * 2021-12-08 2022-04-01 东华大学 Preparation method of antibacterial wound dressing capable of promoting healing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030021832A1 (en) * 2001-07-26 2003-01-30 Scherr George H. Silver alginate foam compositions
CN1935268A (en) * 2006-10-18 2007-03-28 上海川本卫生材料有限公司 Nano silver calcium alginate antibacterial dressing
CN101757681A (en) * 2010-01-05 2010-06-30 嘉兴学院 Zinc-containing alginic acid hydrogel medical dressing, preparation method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030021832A1 (en) * 2001-07-26 2003-01-30 Scherr George H. Silver alginate foam compositions
CN1935268A (en) * 2006-10-18 2007-03-28 上海川本卫生材料有限公司 Nano silver calcium alginate antibacterial dressing
CN101757681A (en) * 2010-01-05 2010-06-30 嘉兴学院 Zinc-containing alginic acid hydrogel medical dressing, preparation method and application thereof

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105169408B (en) * 2015-10-13 2018-09-25 广东泰宝医疗科技股份有限公司 A kind of sodium alginate antimicrobial spray and preparation method thereof
CN105169408A (en) * 2015-10-13 2015-12-23 广东泰宝医疗科技股份有限公司 Sodium alginate antibiosis spray and preparation method thereof
CN105497964A (en) * 2015-12-17 2016-04-20 青岛明月生物医用材料有限公司 Fucoidin-alginate sponge and preparation method thereof
CN105412981A (en) * 2015-12-29 2016-03-23 无锡恒成医疗科技股份有限公司 Medical alginate hydrogel, production technology and applications thereof
CN105662713A (en) * 2015-12-29 2016-06-15 无锡恒成医疗科技股份有限公司 Medical dressing for treating large area wound and manufacturing method thereof
CN105412981B (en) * 2015-12-29 2018-12-28 无锡恒成医疗科技股份有限公司 A kind of medical alginate hydrogel and production technology and its application
RU2627855C1 (en) * 2016-11-28 2017-08-14 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Hemostatic sponge (versions)
RU2639379C1 (en) * 2016-11-28 2017-12-21 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Hemostatic coating in form of sponge or film (versions)
CN106723389A (en) * 2016-11-29 2017-05-31 东莞市广信知识产权服务有限公司 A kind of long-acting magnetotherapy thermal underwear and preparation method thereof
CN106579573B (en) * 2016-11-29 2018-05-04 东莞市广信知识产权服务有限公司 A kind of long acting antibiotic cold-proof underwear and preparation method thereof
CN106723389B (en) * 2016-11-29 2018-06-01 东莞市广信知识产权服务有限公司 A kind of preparation method of long-acting magnetotherapy thermal underwear
CN106579573A (en) * 2016-11-29 2017-04-26 东莞市广信知识产权服务有限公司 Long-acting antibacterial warm-keeping underwear and preparation method thereof
CN107261190A (en) * 2017-06-12 2017-10-20 北京化工大学常州先进材料研究院 A kind of gradient crosslinked type medical wound transparent dressing of sodium alginate/hydroxymethyl cellulose/gelatin interpenetrating networks and preparation method thereof
CN107456602A (en) * 2017-08-04 2017-12-12 北京化工大学常州先进材料研究院 A kind of medical aquogel body dressing of the short fine enhancing of full biodegradable and preparation method thereof
CN108295298A (en) * 2018-01-25 2018-07-20 四川大学 A kind of calcium alginate perforated membrane of the basic zirconium phosphate containing carrying metal ion and preparation method thereof
CN109331215A (en) * 2018-11-01 2019-02-15 河南驼人贝斯特医疗器械有限公司 A kind of medical antibacterial sponge and preparation method thereof
CN112807477A (en) * 2020-12-30 2021-05-18 广州迈普再生医学科技股份有限公司 Composite hemostatic material and preparation method thereof
CN112807477B (en) * 2020-12-30 2023-03-07 广州迈普再生医学科技股份有限公司 Composite hemostatic material and preparation method thereof
CN114259598A (en) * 2021-12-08 2022-04-01 东华大学 Preparation method of antibacterial wound dressing capable of promoting healing

Also Published As

Publication number Publication date
CN104623722B (en) 2017-03-15

Similar Documents

Publication Publication Date Title
CN104623722B (en) A kind of alginic acid antibacterial anti hemorrhagic sponge material and preparation method
TWI693929B (en) Antibacterial wound dressing
CN100411690C (en) Bacteriostatic porous polyelectrolyte material and its prepn process
CN101708341B (en) Method for preparing Ag-carrying bacterial cellulose hydrogel antimicrobial dressing and product thereof
CN104069537B (en) Sodium alginate-sodium carboxymethyl cellulose-Chitosan in Wound Dressing and preparation method thereof
WO2012136082A1 (en) A chitosan wound dressing and its method of manufacturing
CN103255615B (en) Carboxyethyl chitosan fiber and preparation method thereof
CN101905031B (en) Method for preparing flamazine/bacterial cellulose composite wound dressing
CN105617449A (en) Multifunctional microporous styptic powder and preparation method thereof
Deineka et al. Hemostatic performance and biocompatibility of chitosan-based agents in experimental parenchymal bleeding
CN107693835A (en) A kind of polyvinyl alcohol/collagen/n-trimethyl chitosan chloride electrospun composite fibers film and preparation method thereof
CN103120803A (en) Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing
CN103360613B (en) A kind of gelatin/nano silver composite material adopting microbial transglutaminase to modify and its preparation method and application
CN103397509A (en) Preparation method for antibacterial liquid-absorbing gauze
CN107296975A (en) A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof
CN103357060B (en) Method for preparing bacterial cellulose composite fish collagen wound dressing
CN104231299A (en) Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing
CN105288698A (en) Calcium alginate composite medical surgical dressing and preparation method thereof
Li et al. Construction of porous structure-based carboxymethyl chitosan/sodium alginate/tea polyphenols for wound dressing
CN104606710B (en) A kind of preparation method of high antibiotic property alginate dressing
CN105944135A (en) Composite sponge and preparation method thereof
CN102886066A (en) Preparation method of calcium-containing soluble hemostatic material
CN103407205B (en) Konjac glucomannan fiber wet tissue and method for preparing same
CN104610568A (en) Preparation method of chitosan iodide sponge dressing
CN111118878A (en) Silver ion alginate wound dressing and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant