CN101757681A - Zinc-containing alginic acid hydrogel medical dressing, preparation method and application thereof - Google Patents
Zinc-containing alginic acid hydrogel medical dressing, preparation method and application thereof Download PDFInfo
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- CN101757681A CN101757681A CN201010039523A CN201010039523A CN101757681A CN 101757681 A CN101757681 A CN 101757681A CN 201010039523 A CN201010039523 A CN 201010039523A CN 201010039523 A CN201010039523 A CN 201010039523A CN 101757681 A CN101757681 A CN 101757681A
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Abstract
The invention discloses a zinc-containing alginic acid hydrogel medical dressing, a preparation method and application thereof. The hydrogel medical dressing comprises zinc alginate fibers, sodium alginate powder and water, wherein the weight ratio of the zinc alginate fibers to the sodium alginate powder is 1:0.4 to 9, and the ratio between the total weight of the zinc alginate fibers and the sodium alginate powder and the weight of the water is 1:10 to 100. An experiment shows that the hydrogel medical dressing has the advantages of high dampening property, convenient use, safety and nontoxicity, and the hydrogel medical dressing can be used as medical dressing for treating wounds. The operation of the preparation method for the hydrogel medical dressing is simple, and the preparation method is applicable to industrial production.
Description
Technical field
The present invention relates to the medical accessory field, be specifically related to a kind of Zinc-containing alginic acid hydrogel medical dressing and its production and application.
Background technology
Wound is a kind of integrity and successional destruction to human body skin.In the daily life, the kind of wound is a lot, comprises the burn that is caused by factors such as machinery, electricity, heat, chemistry, and because patient's the morphogenetic chronic trauma of physiological disease.Often occur because chronic wounds such as the decubital ulcer that poor circulation causes, ulcer among the old people.In recent years, along with the aging of global population, the chronic ulcerative wound is in the whole world, and particularly American-European countries presents the trend that significantly increases.
Medical dressing is the material of a kind of flap coverage, auxiliary wound healing.From the 1980's so far, along with the progress of science and technology and the people deep understanding to wound healing process and wound care process, many novel materials are used in the preparation of medical dressing.On high-tech medical dressing market, use many materials at present and comprise materials such as calcium alginate fibre, polyurethane film and foam, hydrocolloid, hydrogel, carboxymethyl cellulose.After these medical dressing that are called as " wet method therapy " product covered on the wound, wound fluid all or part of was maintained in the structure of dressing, forms a moistening microenvironment in wound surface.Because moistening substrate is moved and propagation has facilitation epithelial gushing, therefore, this " wet method therapy " product can be accelerated the healing rate of wound.
In the agglutination of wound, zinc ion plays very important effect.The existing excellent antibiotic performance of zinc ion also has the function of auxiliary wound healing.Zinc is one of minor metallic element of needed by human, and zinc deficiency can have a strong impact on the healing of wound.And the formation of human body wound can cause the loss of zinc ion.It is 2 times of normal person that the patient of burn surface area 10%～33% urinates the zinc output average every day, and it is 5 times of normal person that the patient of burn surface area 34%～77% urinates the zinc output.Can play the effect that promotes wound healing for the wound surface zinc supplement.
Alginic acid is a kind of water soluble polymer polysaccharide that extracts in natural seaweed, it is a kind of natural polymer copolymer of being made up of α-L-guluronic acid and beta-D-mannuronic acid, and the chemical constitution of α-L-guluronic acid and beta-D-mannuronic acid is as follows:
Alginic acid extensively is present among the Brown algae, and exsiccant Brown algae generally contains 20% the alginic acid of having an appointment.The process of extracting alginic acid from Sargassum comprises: after the results Sargassum, Sargassum through washing, grinding, is dissolved the intravital alginic acid of algae with aqueous slkali then.Through further separating and filter, the alginic acid that extracts in the Sargassum is through super-dry with grind the water miscible sodium alginate powder of back formation.After sodium alginate was dissolved in water, its aqueous solution can combine with bivalent metal ion and form water-fast colloid.
Sodium alginate can also be processed into fiber by wet spinning technology.Sodium alginate forms solution after being dissolved in water, after can being squeezed into the calcium chloride water of 1% (mass percentage concentration) by spinneret orifice, the spinning solution that contains 5% (mass percentage concentration) sodium alginate forms the calcium alginate strand, through further technologies formation calcium alginate fibres such as washing, drying.The non-woven fabrics that is processed into by calcium alginate fibre has very high moisture pick-up properties, is to be used for the treatment of the good medical dressing of more wound of suppurating of bleeding.Since the 1980's, various countries, west medical profession has been made many detailed clinical researches, the premium properties of verified its nuring wound to calcium alginate fibre and medical dressing.The alginic acid medical dressing that many types have been arranged on the present American-European market.
Sodium alginate aqueous solution can form alginic acid zinc strand after clamp-oning solder(ing)acid by spinneret orifice, forms alginic acid zinc fibers through technologies such as further washing, dryings.Alginic acid zinc fiber has similar high hygroscopic property to the calcium alginate non-woven fabrics after being processed into non-woven fabrics, and because the release of zinc ion has better anthemorrhagic performance.
Summary of the invention
After utilizing sodium alginate and zinc ion combines, the present invention can form water-fast colloid, and alginic acid zinc fiber not only can discharge zinc ion but also has the characteristic of stability of fiber, provide a kind of have very high to wet performance with the novel zinc-containing alginic acid hydrogel medical dressing of function and its production and application of well applying ointment or plaster.
A kind of Zinc-containing alginic acid hydrogel medical dressing is made up of alginic acid zinc fiber, sodium alginate powder and water; Wherein, the weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 0.4～9, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 10～100 with the ratio of the weight of water.
Because sodium alginate is water miscible, and alginic acid zinc is water-fast, good gives moistly for the hydrogel that makes formation is existing, and good mobility is arranged again, covers on the wound smearing easily, and is preferred:
The weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 0.4～4, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 10～35 with the ratio of the weight of water.
Further preferred, the weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 1, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 20 with the ratio of the weight of water.
The preparation method of described Zinc-containing alginic acid hydrogel medical dressing comprises the steps:
(1) alginic acid zinc fiber is mixed with the water that accounts for water gross weight 1/4th to 1/2nd, make alginic acid zinc fiber solution;
(2) sodium alginate powder is dissolved in the water of surplus, makes sodium alginate soln;
(3) above-mentioned alginic acid zinc fiber solution is mixed with sodium alginate soln, stir, make Zinc-containing alginic acid hydrogel medical dressing.
The length of described alginic acid zinc fiber is preferably 15mm.
The preparation that the present invention contains the zinc hydrogel medical dressing also can be processed into non-woven fabrics in advance with alginic acid zinc fiber, combines with sodium alginate aqueous solution then.What form like this contains the structure that has kept non-woven fabrics in the zinc hydrogel medical dressing, can directly apply ointment or plaster on wound.Concrete preparation method comprises the steps:
(1) sodium alginate powder is dissolved in the water, makes sodium alginate soln;
(2) will adopt the non-woven fabrics of alginic acid zinc fiber production to put into sodium alginate soln and be placed to the formation colloid, make Zinc-containing alginic acid hydrogel medical dressing.
Described alginic acid zinc fiber can select for use the commercially available prod also can to prepare voluntarily according to the preparation method of this area routine, its preparation method generally comprises: sodium alginate is dissolved in forms alginic acid zinc fiber after the spinning solution that forms behind the water is clamp-oned solder(ing)acid by spinneret orifice, the length of this fiber is generally 5mm～100mm.
The present invention contains alginic acid zinc fiber in the zinc hydrogel medical dressing with after sodium alginate in the solution combines, can discharge a part of zinc ion in the fiber, enter behind the solution to combine and form alginic acid zinc colloid with sodium alginate in the solution, and fiber originally is converted into sodium alginate after ion exchange, forms the fibrous hydrogel of high level expansion.The hydrogel colloid of Xing Chenging combines the wet performance of giving of alginic acid hydrogel like this, and the structural stability of fiber, has both had the very high wet performance of giving, and has the good function of applying ointment or plaster again.
Described Zinc-containing alginic acid hydrogel medical dressing can be used for preparation treatment wound with in the medical accessory.
Hydrogel is specially adapted to common body surface wound, as various skin injurys such as scratch, scuffing, decubital ulcers.For these wounds, generally handle clinically with sterile gauze and topical antibiotic.Because common gauze is easy and impaired skin histology adhesion, usually destroys newborn epithelium and granulation tissue when changing dressings, and causes bleeding, and makes patient's pain unbearably.When applying ointment or plaster wound with aerogel dressing, it not only the adhesion wound, do not destroy cambium, and can kill various antibacterials, avoid wound infection.
The zinc hydrogel medical dressing that contains of the present invention is different from general hydrogel medical dressing greatly on performance, effect, owing to the high-hygroscopicity alginic acid zinc fiber that is scattered in the colloid has continual and steady " moisturizing " effect.Compare with general hydrogel,, have good performance aspect trophism, breathability, spatter property and the convenience owing to can stablize, feed water constantly as the alginic acid fibre base material of intermediate products.Particularly prepare the present invention and contain the alginic acid zinc fiber that uses in the zinc hydrogel medical dressing and contain the zinc ion that to assist wound healing, have the performance of certain inhibition bacterial growth.
Can provide zinc ion for human body by oral and wound surface clinically.Applying ointment or plaster on wound surface contains the zinc medical dressing and can play the effect that replenishes zinc ion into wound surface is local, makes wound surface directly obtain zinc.Histological examination confirms that granulation tissue, blood capillary and fibroblast subcutaneous after the wound surface zinc supplement are abundanter than oral zinc reinforcing.
It is that wound surface provides zinc ion with zinc oxide and zinc sulfate traditionally that prior art for preparing contains the zinc medical dressing.Because zinc sulfate is water miscible, can not play slow releasing function during application.And zinc oxide is water insoluble, can not discharge zinc ion effectively.The zinc ion that the present invention utilizes alginic acid zinc fiber to discharge combines formation with the aqueous solution of sodium alginate and contains the zinc hydrogel medical dressing.With after sodium ion in the wound fluid contacts, can discharge the zinc ion that wound healing is had facilitation constantly.
Alginic acid zinc fiber discharges the test of zinc ion
Take by weighing 5g alginic acid zinc fiber, put into the A solution of 40 times of fibre weight (200g), stir with magnetic stirrer, pipetted liquid to 1000mL volumetric flask standardize solution with the 10mL pipet at 0.5 hour, 1 hour, 3 hours, 8 hours, 24 hours respectively on 5 time points under the room temperature, filter, get filter rear section liquid and deposit, measure the content of zinc ion in the solution, the results are shown in Table 1 to the 50mL reagent bottle.
British Pharmacopoeia has proposed to contain the A solution of sodium ion and calcium ion as standard test liquid in the process of the method for testing that forms the alginic acid medical dressing, this A solutions simulate that contains sodium and calcium ion calcium ion in the wound fluid and the content of sodium ion, by CaCl
22H
2O and NaCl are water-soluble formulated, wherein CaCl
22H
2The concentration of O be 2.5 mMs/liter, the concentration of NaCl be 142 mMs/liter.A solution can be by 8.3 gram NaCl and 0.367 gram CaCl
22H
2O disposes after being diluted to 1 liter.
The concentration of table 1 zinc ion in alginic acid zinc fiber and solution after the A solution that contains sodium ion contacts
| Time of contact | Zinc ion concentration, mg/L |
| ??30min | ??7.08 |
| ??1h | ??7.24 |
| ??3h | ??7.75 |
| ??8h | ??7.86 |
| ??24h | ??8.17 |
Result in the table 1 shows: when alginic acid zinc fiber with after the A solution that contains sodium ion contacts, zinc ion can be discharged into the solution from fiber.
Zinc-containing alginic acid hydrogel medical dressing of the present invention is carried out showing hydrogel medical dressing of the present invention to wet test has very high giving wet performance and be better than present commercially available prod.The experiment proved that it is easy to use that the present invention contains the zinc hydrogel medical dressing, safety non-toxic.
The preparation method of Zinc-containing alginic acid hydrogel medical dressing of the present invention, simple to operate, be suitable for suitability for industrialized production.
The specific embodiment
The preparation of embodiment 1～5 Zinc-containing alginic acid hydrogel medical dressing
Alginic acid zinc fiber is cut into the long short fiber of 15mm.Preparation condition according to table 2 prepares different Zinc-containing alginic acid hydrogels.When the sample of preparation embodiment 1, take by weighing 1 gram alginic acid zinc fiber and 50 ml waters and mix, take by weighing 9 gram sodium alginates and be dissolved in 150 ml waters, then above-mentioned two solution are mixed, promptly make Zinc-containing alginic acid hydrogel medical dressing.
Because discharging into solution from fiber, zinc ion make the sodium alginate interlinkage in the solution form colloid.The preparation condition preparation that the sample of embodiment 2, embodiment 3, embodiment 4 and embodiment 5 shows according to table 2 successively obtains the Zinc-containing alginic acid hydrogel medical dressing that different component is formed.
The preparation condition of the Zinc-containing alginic acid hydrogel medical dressing of table 2 different component
The Zinc-containing alginic acid hydrogel medical dressing of embodiment 1～5 preparation give wet test
After the A solution mixing of the gelatin of 17.5 grams and 32.5 grams, in 60 ℃ of water-baths, gelatin is fully dissolved, pour the surface plate that diameter is 90mm then into, cooling back gelatin solution is frozen into the dermatoid colloid of one deck class.Placement one deck aperture is 100 microns a nylon wire on gelatin, then on nylon wire, put a diameter and be 35mm, highly be the plastic tube of 10mm, after being placed on the Zinc-containing alginic acid hydrogel medical dressing of 5 gram embodiment, 1～5 preparation in the plastic tube equably surface plate is sealed, Zinc-containing alginic acid hydrogel medical dressing, plastic tube and nylon wire are removed from gelatin after leaving standstill 48 hours at 20 ℃～22 ℃, be determined at the weight difference of gelatin before and after the test.The gelatin of 35% (quality percentage composition) has been represented exsiccant skin (being simulated skin), and the weight that the dermatoid colloid of class increases in test is the dewing amount of Zinc-containing alginic acid hydrogel medical dressing, the results are shown in Table 3.
Table 3 Zinc-containing alginic acid hydrogel medical dressing with dewing amount after 35% gelatin contacts
| Embodiment | The dewing amount, gram |
| ????1 | ????1.222 |
| ????2 | ????2.138 |
| ????3 | ????2.835 |
| ????4 | ????2.262 |
| ????5 | ????2.497 |
As can be seen from Table 3, Zinc-containing alginic acid hydrogel medical dressing with all can play the effect that a moistening healing environment is provided for wound clinically after simulated skin contacts for skin provides moisture.
Comparative test
Zinc-containing alginic acid hydrogel medical dressing with the embodiment of the invention 5 preparation is representative, and the hydrogel (Sterigel hydrogel) of the commodity Sterigel by name that produces with Britain SSL company carries out the comparative test of dewing amount.
After gelatin and the mixing of A solution, in 60 ℃ of water-baths, gelatin is fully dissolved, pour the surface plate that diameter is 90mm then into, cooling back gelatin solution is frozen into the dermatoid colloid of one deck class.The Zinc-containing alginic acid hydrogel medical dressing of embodiment 5 preparations is contacted with the gelatin of variable concentrations respectively with the Sterigel hydrogel, measure the dewing amount, the results are shown in Table 4.
The dewing amount of table 4 Zinc-containing alginic acid hydrogel medical dressing and Sterigel hydrogel relatively
Table 4 has shown with after the gelatin of variable concentrations contacts, the Zinc-containing alginic acid hydrogel medical dressing of embodiment 5 preparations and the dewing amount of Sterigel hydrogel.In the gelatin mass percentage concentration is 20% o'clock, and two kinds of hydrogels have the function that absorbs moisture from gelatin, illustrates when time on the wound of Zinc-containing alginic acid hydrogel medical dressing use in humidity to have the effect that absorbs pus and blood from wound.DANGMING colloid amount percentage concentration is higher than at 20% o'clock, two kinds of hydrogels have the effect that moisture is provided for gelatin, clinically, when these two kinds of hydrogel products are used on the wound with dry crusts, moisture in the hydrogel is transferred in the dry crusts structure, it is decomposed, and then play the effect of cleaning wound surface.The comparative test result shows that Zinc-containing alginic acid hydrogel medical dressing has better serviceability than Sterigel hydrogel.
The preparation of embodiment 6～9 lamellar Zinc-containing alginic acid hydrogel medical dressings
Take by weighing 5g sodium alginate and 95g preservative propylene glycol with electronic balance, graduated cylinder is measured the 400mL distilled water, pours in the 1000mL beaker, is stirred to abundant dissolving, and the formation mass concentration is 1% sodium alginate aqueous solution.
By diameter is the non-woven fabrics of the culture dish shape clip alginic acid zinc fiber production of 90mm, 40 times by non-woven fabrics weight after the weighing calculate required sodium alginate soln amount, take by weighing solution and pour in the culture dish, leave standstill 2min～3min deaeration, add alginic acid zinc fabric nonwoven cloth, after room temperature is placed 24h down,, zinc ion forms colloid, i.e. lamellar Zinc-containing alginic acid hydrogel medical dressing because discharging the sodium alginate that makes in the solution from alginic acid zinc fiber.
Adopting same quadrat method, is 30: 1,45: 1,50: the 1 different lamellar Zinc-containing alginic acid hydrogel medical dressings of preparation according to sodium alginate soln and weight ratio between the non-woven fabrics.
The lamellar Zinc-containing alginic acid hydrogel medical dressing give wet performance
The method preparation quality percentage concentration in the wet test of giving according to the Zinc-containing alginic acid hydrogel medical dressing of the foregoing description 1～5 preparation is 35% aqueous gelatin solution, and the cooling back forms simulated skin.The lamellar Zinc-containing alginic acid hydrogel medical dressing of the different proportion of preparation among the embodiment 6 is cut into the sheet of 2cm * 2cm, after being placed on the gelatin, surface plate is sealed, lamellar Zinc-containing alginic acid medical dressing is removed from gelatin after leaving standstill 48 hours at 20 ℃～22 ℃, be determined at Zinc-containing alginic acid medical dressing weight before and after the test.The Zinc-containing alginic acid medical dressing that table 5 has shown different proportion with dewing amount after 35% gelatin contacts.
The lamellar Zinc-containing alginic acid hydrogel medical dressing of table 5 different proportion with dewing amount after 35% gelatin contacts
| Embodiment | The weight ratio of sodium alginate soln and non-woven fabrics | Zinc-containing alginic acid medical dressing initial weight, g | Zinc-containing alginic acid medical dressing final weight, g | Weight change before and after the test, g | Character |
| 6 | 30∶1 | 1.751 | 1.833 | ?0.082 | Suction |
| ??7 | ????40∶1 | ????1.595 | ????1.446 | ????-0.149 | Feedwater |
| ??8 | ????45∶1 | ????2.803 | ????2.544 | ????-0.259 | Feedwater |
| ??9 | ????50∶1 | ????2.412 | ????2.151 | ????-0.261 | Feedwater |
Can find out from table 5, when the weight ratio of sodium alginate soln and non-woven fabrics is 30: 1, because the solids content height in the Zinc-containing alginic acid medical dressing that obtains, colloid absorbs moisture from skin when contacting with simulated skin, can absorb the transudate that wound produces clinically.And when the weight ratio between sodium alginate soln and the non-woven fabrics was above at 40: 1, the Zinc-containing alginic acid medical dressing that obtains had tangible feedwater effect, can play the effect into the wound dewing.
The Zinc-containing alginic acid hydrogel medical dressing anti-microbial property test of embodiment 1～9 preparation
Add 800mL water in the 1000mL beaker, add 5g Carnis Bovis seu Bubali cream, 10g peptone, 5gNaCl, be settled to 1000mL after the heating for dissolving, the reuse mass percentage concentration is 10% NaOH aqueous solution accent pH to 7.2～7.5, makes fluid medium.
The fluid medium that mixes up pH is added 20g agar under fluidized state, constantly stir till dissolving fully.After agar dissolves fully, moisture evaporated in the supplementary heating process.Pouring dissolved agar solution into diameter is in 90 millimeters the culture dish, and the cooling back forms agaropectin.
Make the agaropectin in the culture dish form mutually independently two after cutting out the wide culture medium of 10mm in the middle of the agaropectin, on culture medium on one side, evenly coat strain.The wide dressing of 10mm ridden on two culture medium add a small amount of pure water after forming a bridge in the middle of two agaropectins, the Zinc-containing alginic acid hydrogel medical dressing of common calcium alginate medical dressing and embodiment 1～9 preparation is selected in dressing respectively for use.Observe the dull and stereotyped growing state of going up antibacterial behind 37 ℃ of cultivations of constant temperature 24h.
The result shows that antibacterial spreads along common calcium alginate dressing, and the breeding back forms bacterium colony on the agaropectin of strain not coating; The Zinc-containing alginic acid hydrogel medical dressing diffusion that antibacterial prepares along embodiment 1～9, and do not coating formation bacterium colony in breeding back on the agaropectin of strain.The Zinc-containing alginic acid hydrogel medical dressing of the embodiment of the invention 1～9 preparation has the performance that stops the antibacterial diffusion.
Claims (7)
1. a Zinc-containing alginic acid hydrogel medical dressing is made up of alginic acid zinc fiber, sodium alginate powder and water; Wherein, the weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 0.4～9, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 10～100 with the ratio of the weight of water.
2. Zinc-containing alginic acid hydrogel medical dressing as claimed in claim 1, it is characterized in that, the weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 0.4～4, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 10～35 with the ratio of the weight of water.
3. Zinc-containing alginic acid hydrogel medical dressing as claimed in claim 2 is characterized in that, the weight ratio of alginic acid zinc fiber and sodium alginate powder is 1: 1, and the gross weight of alginic acid zinc fiber and sodium alginate powder is 1: 20 with the ratio of the weight of water.
4. as the preparation method of each described Zinc-containing alginic acid hydrogel medical dressing of claim 1～3, comprise step:
(1) alginic acid zinc fiber is mixed with the water that accounts for water gross weight 1/4th to 1/2nd, make alginic acid zinc fiber solution;
(2) sodium alginate powder is dissolved in the water of surplus, makes sodium alginate soln;
(3) above-mentioned alginic acid zinc fiber solution is mixed with sodium alginate soln, stir, make Zinc-containing alginic acid hydrogel medical dressing.
5. preparation method as claimed in claim 4 is characterized in that, the length of described alginic acid zinc fiber is 15mm.
6. as the preparation method of each described Zinc-containing alginic acid hydrogel medical dressing of claim 1～3, comprise step:
(1) sodium alginate powder is dissolved in the water, makes sodium alginate soln;
(2) will adopt the non-woven fabrics of alginic acid zinc fiber production to put into sodium alginate soln and be placed to the formation colloid, make Zinc-containing alginic acid hydrogel medical dressing.
7. the application of Zinc-containing alginic acid hydrogel medical dressing as claimed in claim 1 in preparation treatment wound usefulness medical accessory.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847196A (en) * | 2012-07-31 | 2013-01-02 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN104623722A (en) * | 2015-02-13 | 2015-05-20 | 青岛明月生物医用材料有限公司 | Alginic acid antibacterial hemostatic sponge material and preparation method thereof |
| CN105169454A (en) * | 2015-07-20 | 2015-12-23 | 吴玉松 | Composite alginate hydrogel dressing as well as preparation method and application thereof |
| CN105412981A (en) * | 2015-12-29 | 2016-03-23 | 无锡恒成医疗科技股份有限公司 | Medical alginate hydrogel, production technology and applications thereof |
| CN105662713A (en) * | 2015-12-29 | 2016-06-15 | 无锡恒成医疗科技股份有限公司 | Medical dressing for treating large area wound and manufacturing method thereof |
| CN106994133A (en) * | 2016-01-25 | 2017-08-01 | 吉林省莱沃医疗科技有限公司 | Calcium zinc ion is combined antibacterial alginate slow-release material and preparation method thereof |
| CN111512810A (en) * | 2020-06-04 | 2020-08-11 | 湖南省蔬菜研究所 | Melon grafting seedling method |
| CN113336974A (en) * | 2021-07-21 | 2021-09-03 | 浙江大学 | Easily degradable histidine-based coordination hydrogel with fluidity and preparation method and application thereof |
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2010
- 2010-01-05 CN CN201010039523A patent/CN101757681A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847196A (en) * | 2012-07-31 | 2013-01-02 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN102847196B (en) * | 2012-07-31 | 2014-04-16 | 宁波宏搏高科医疗器械有限公司 | Wet wound surface dressing and preparation method thereof |
| CN104623722A (en) * | 2015-02-13 | 2015-05-20 | 青岛明月生物医用材料有限公司 | Alginic acid antibacterial hemostatic sponge material and preparation method thereof |
| CN105169454A (en) * | 2015-07-20 | 2015-12-23 | 吴玉松 | Composite alginate hydrogel dressing as well as preparation method and application thereof |
| CN105412981A (en) * | 2015-12-29 | 2016-03-23 | 无锡恒成医疗科技股份有限公司 | Medical alginate hydrogel, production technology and applications thereof |
| CN105662713A (en) * | 2015-12-29 | 2016-06-15 | 无锡恒成医疗科技股份有限公司 | Medical dressing for treating large area wound and manufacturing method thereof |
| CN106994133A (en) * | 2016-01-25 | 2017-08-01 | 吉林省莱沃医疗科技有限公司 | Calcium zinc ion is combined antibacterial alginate slow-release material and preparation method thereof |
| CN111512810A (en) * | 2020-06-04 | 2020-08-11 | 湖南省蔬菜研究所 | Melon grafting seedling method |
| CN113336974A (en) * | 2021-07-21 | 2021-09-03 | 浙江大学 | Easily degradable histidine-based coordination hydrogel with fluidity and preparation method and application thereof |
| CN113336974B (en) * | 2021-07-21 | 2022-06-10 | 浙江大学 | Easily degradable histidine-based coordination hydrogel with fluidity and preparation method and application thereof |
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Application publication date: 20100630 |