CN109620547A - It is a kind of to have effects that alleviate the tapon and preparation method thereof of gynecological disease - Google Patents
It is a kind of to have effects that alleviate the tapon and preparation method thereof of gynecological disease Download PDFInfo
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- CN109620547A CN109620547A CN201811522200.8A CN201811522200A CN109620547A CN 109620547 A CN109620547 A CN 109620547A CN 201811522200 A CN201811522200 A CN 201811522200A CN 109620547 A CN109620547 A CN 109620547A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2082—Apparatus or processes of manufacturing
- A61F13/2085—Catamenial tampons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/02—Local antiseptics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
- A61F2013/8408—Additives, e.g. for odour, disinfectant or pH control with odour control
- A61F2013/8414—Additives, e.g. for odour, disinfectant or pH control with odour control with anti-microbic
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Abstract
The invention belongs to amenities technical fields, disclose a kind of tapon and preparation method thereof with alleviation gynecological disease.Tapon of the invention uses alginate fibre that tapon is made for the first time, and according to the particularity of alginate fibre, pre-treatment is carried out to it using special process, it is effectively maintained its antibacterial characteristics, in conjunction with effective component of the sprinkling containing motherwort, it can play the role for the treatment of irregular menstruation, dysmenorrhea, through gynecological diseases such as cold and palace colds, be directly in contact with vagina using the bioactive molecule of motherwort when tapon, there is more direct therapeutic effect.
Description
Technical field
The invention belongs to amenities technical fields, have effects that alleviate defending for gynecological disease more particularly, to a kind of
Raw sliver and preparation method thereof.
Background technique
Tapon is a kind of catamenial devices, is contacted by woman's vaginal cavity and absorbs menstruation stream to prevent menstruation outflow yin
Road junction.Built-in tapon because use when do not influence wear clothes and move, absorb sufficiently will not side leakage, by more and more people
Approve and uses.
However, meta-alkalescence after tapon use, bacterium easy to breed, so as to cause various gynecological diseases such as vaginitis
Generation, and since tapon is contacted with vaginal epithelial cell the resistance of body may closely declined；When replacement interval
Between the too long endometrium that also results in it is dry and cracked, intravaginal staphylococcus aureus can enter blood circulation system, generate poisoning stops
Gram syndrome.If not taking effective sterilization measure in female menstrual period, toxic shock syndromes are removed in time, will also further be occurred
Irregular menstruation, dysmenorrhea caused by pruritus of vagina, cervicitis, the pelvic inflammatory disease blood stasis deficiency of blood, through gynecological diseases such as cold and palace colds.Therefore,
Preparing, there is the tapon of bactericidal bacteriostasis to become research hotspot.
Alginate fibre is in seaweed plants (such as kelp, sea grass) points as a kind of Biodegradable regenerated fiber
The alginic acid separated out is fiber made of raw material.Since its product has good biocompatibility, degradable absorbability, resource
The features such as abundant, and it is widely used in the fields such as medicine, amenities.In order to further enhance the antibacterial of alginate fibre product
Characteristic, the prior art usually attach antibiotic layer on alginate fibre product, and this method collects antibiotic layer effective component mainly
In in product subsurface, cause drug and skin exposure big, timeliness is short, is irritating to the skin, and it is immune to destroy human body itself clean
System, and have not yet to see and be applied to prepare the relevant report of tapon about alginate fibre.
Summary of the invention
For deficiency existing for tapon in the prior art, has the purpose of the present invention is to provide one kind and alleviate gynaecology
The tapon and preparation method thereof of disease effect.The present invention uses alginate fibre that tapon is made for the first time, utilizes seaweed fibre
The antibacterial characteristics of dimension, and medical fluid is sprayed on tapon ontology and non-woven fabrics, effectively solve tapon bacterium easy to breed
The problem of, avoid the appearance of the various gynecological diseases caused because using tapon.
The purpose of the present invention is achieved through the following technical solutions:
A kind of preparation method of the tapon alleviate with gynecological disease, comprising the following steps:
S1. pre-treatment: using desizing enzyme, bleeding agent and scouring agent at a certain temperature to the fiber Jing Guo starching at
Reason；
S2. fiber mixes: by after pre-treatment alginate fibre and cotton fiber mix in specified weight ratio；
S3. the composite fibre for weighing fixed weight is pressed into fibre strip layer, and effective component is then sprayed at strip fibre
Layer surface is tieed up, obtains the fibre strip layer with effective component after dry；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with band
There is the non-woven fabrics of effective component by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton
The exposed certain length outside cotton core of line tail end；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, then will
It is placed in conduit to get tapon finished product；
Wherein, the effective component includes following parts by weight of component: 6~12 parts of motherwort, 2~8 parts of wormwood, and Radix Glycyrrhizae 4~9
Part, 3~6 parts of Radix Angelicae Sinensis, 5~8 parts of rhizoma zingiberis.
The characteristics of present invention is according to alginate fibre carries out pre-treatment to alginate fibre using special process, not but not right
Fiber causes to damage, additionally it is possible to so that alginate fibre sufficiently softens, be sufficiently reserved the antibacterial characteristics of alginate fibre, and alginate fibre
Quality be effectively improved so that alginate fibre has preferably soft skin fitness, improve the row yielding and quality of product.
After the present invention is mixed alginate fibre and cotton fiber in specified weight ratio, it is applied to prepares cotton wool for the first time
Item effectively inhibits the growth of bacterium using the antibacterial action of alginate fibre；By on tapon ontology and outer layer non-woven fabrics
Medical fluid is sprayed, restraining and sterilizing bacteria effect of tapon is enhanced.
Further, in step S1, the pre-treating method of alginate fibre are as follows: it is 60~65 DEG C that alginate fibre, which is put temperature,
In water, the proportion of 1.5~2.0g of desizing enzyme, 1.2~1.5g of bleeding agent, 1.6~2.0g of scouring agent are then added by every liter of water, it will
Desizing enzyme, bleeding agent, scouring agent are added to the water and are mixed into treatment fluid；Then treatment fluid is warming up to 80~85 DEG C, it will
Alginate fibre in above-mentioned treatment fluid transfer 12~15, finally by sink treatment fluid release to get.
By treated alginate fibre, the desizing grade requirement of alginate fiber fabric semi-finished product can be reached, simultaneously
Due to entire treatment process no alkaline agent, weak oxide environment in carry out, metal cation in alginate fiber fabric (silver from
Son), alginate will not be lost.In subsequent process, physical property, physical index are not destroyed, and are more had
Conducive to following process utilization.
Further, the desizing enzyme is medium temperature amylase；The bleeding agent is nonionic penetrant；The scouring agent
For scouring agent 880 or scouring agent 120B.
Further, by every liter of water be added 1.5~1.8g of desizing enzyme, 1.2~1.4g of bleeding agent, scouring agent 1.6~
1.8g。
In order to balance the pliability and antibacterial bacteriostatic effect of tapon, further, in step S2, the alginate fibre
Weight ratio with cotton fiber is 5~18:82~95；Preferably, the weight ratio of the alginate fibre and cotton fiber is 8~16:84
~92.
Further, in step S2, the weight ratio of the alginate fibre and cotton fiber is 12~15:84~92.
Further, in step S3, the fixed weight of the composite fibre is 2~5g；Preferably, the composite fibre
Fixed weight is 2~4g；Preferably, the fixed weight of the composite fibre is 4g.
Further, in step S3, the effective component includes following parts by weight of component: 10~12 parts of motherwort, wormwood 6
~8 parts, 4~6 parts of Radix Glycyrrhizae, 4~6 parts of Radix Angelicae Sinensis, 6~8 parts of rhizoma zingiberis.
Further, in step S3, the fountain height of effective component is the 20~30% of fibre strip layer quality, in 60~65
The fibre strip layer with effective component is obtained after drying at DEG C；Preferably, the fountain height of the effective component is fibre strip
The 20~28% of layer quality, drying temperature are 60~64 DEG C.
Further, in step S4, the non-woven fabrics with effective component includes material composition sunflower fiber, viscose glue
Fiber is prepared through following method:
Y1. it pre-processes:
Y11. the preprocess method of sunflower fiber are as follows: 1~5g/L soda ash solution is added, is then impregnated at 50~60 DEG C
50~60min, bath raio are 1:5~10；
Y12. the preprocess method of viscose rayon are as follows: carry out heat in overflow dyeing machine using the emulsifier of 1~3wt.%
Processing, temperature are 90~95 DEG C, and the time is 20~40min；
Y2. raw material mix: by pretreated sunflower fiber and viscose rayon ratio 5~20:80~95 by weight into
Row mixing；
Y3. by composite fibre successively by combing, lapping, 4 spun lacings, drying and coiling process to get sunflower fiber
Spunlace non-woven cloth；
Y4. micro emulsion is atomized: the fiber spun-laced non-woven fabrics of sunflower obtained using step Y3 adds above-mentioned effective component as carrier
Entering by high pressure nozzle jet atomization after 2~5 times of organic solvent dilutings, atomization temperature is 15~20 DEG C, atomizing pressure is 0.1~
0.3MPa, air column jet air pressure are 0.3~0.65MPa, and the Essence after atomization is equal under the high pressure draught effect of upper and lower convection current
It is even to be distributed on the fiber spun-laced non-woven fabrics of sunflower, the non-woven fabrics for having effective component is obtained after sterile drying.
Further, in step S5, the exposed 8~15cm outside cotton core of cotton thread tail end.
It is a kind of it is above-mentioned have effects that alleviate gynecological disease tapon preparation method be prepared have alleviate woman
The tapon of section's disease effect.The tapon inherits the antibacterial characteristics of alginate fibre, at the same also have pro-skin, it is dry and comfortable,
Ventilative effect.
Compared with prior art, the beneficial effects of the present invention are:
The present invention uses natural seaweed fiber to prepare tapon for raw material in a creative way, and according to the special of alginate fibre
Property, pre-treatment is carried out to it using special process, is effectively maintained its antibacterial characteristics, in conjunction with sprinkling effective component, so that this hair
Bright tapon has antibacterial, sterilization and antiinflammation, to skin and vaginal mucosa without any irritation and side effect, smell
It is fragrant, easy to carry.
Contain motherwort in effective component of the invention, treatment irregular menstruation, dysmenorrhea can be played, through woman such as cold and palace colds
The effect of section's disease is directly in contact with vagina using the bioactive molecule of motherwort when tapon, is had more direct
Therapeutic effect plays Chinese medicine medicine in addition, motherwort mixes with progress certain proportions such as Radix Angelicae Sinensis, Radix Glycyrrhizae, rhizoma zingiberis, motherwort, wormwoods
Reason synergistic effect, plays better therapeutic effect for gynecological disease.
It is significant using the tapon soft comfortable, good water absorption, fungistatic effect of effective component of the present invention preparation and
Has the characteristics that easily disperse.
The advantages that effective component and tapon of the present invention are provided with low in cost, long shelf-life, high stability.
Specific embodiment
To facilitate the understanding of the present invention, present invention work more comprehensively, is meticulously described below in conjunction with embodiment, but this hair
Bright protection scope is not limited to embodiment in detail below.
Unless otherwise defined, all technical terms used hereinafter and the normally understood meaning of those skilled in the art
It is identical.Technical term used herein is intended merely to the purpose of description specific embodiment, it is no intended to limit of the invention
Protection scope.
Unless otherwise specified, various raw material, reagent, the instrument and equipment etc. used in the present invention can pass through city
Field is commercially available or can be prepared by existing method.
The extracting method of effective component:
Effective component includes following parts by weight of component: 6~12 parts of motherwort, 2~8 parts of wormwood, and 4~9 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 3
~6 parts, 5~8 parts of rhizoma zingiberis；
Firstly, motherwort is smashed it through 30 meshes, according to the solid-liquid ratio (g:ml) of 1:18, with the second of volume fraction 90%
Alcohol ultrasonic extraction 85min, concentrated extracting solution are to get, wherein the frequency of ultrasonic extraction at the medicinal extract of relative density 1.1~1.3
40kHz, power 500W；
Secondly, extracted, the de- slag of filtering obtains corresponding filtrate, by Radix Glycyrrhizae, wormwood respectively by Radix Angelicae Sinensis, Radix Glycyrrhizae, wormwood boiling
It leaves after boiling and is extracted again；The extracting solution is merged with first time extracting solution；
Finally, Leonurus extract and Radix Angelicae Sinensis, Radix Glycyrrhizae and the mixed extract of wormwood are added into rhizoma zingiberis, mixing is equal
It is even, 90% ethyl alcohol is added, ultrasonic dissolution to clear solution is to get wherein the frequency of ultrasonic dissolution is 40kHz, and power is
500W。
Although a kind of above-mentioned specific embodiment for being only exemplified by each extract, it will be appreciated by those skilled in the art that
Be be not limited to other extracting methods (method especially in the limited range of the present invention) of ad hoc fashion similarly can be with
It realizes essentially identical extraction effect, can be used for realizing the present invention, this is no longer particularly limited.
Embodiment 1
The present embodiment provides a kind of preparation methods of tapon alleviate with gynecological disease, including following step
It is rapid:
S1. pre-treatment: alginate fibre being put in the water that temperature is 60 DEG C, and desizing enzyme 1.5g then is added by every liter of water, seeps
The proportion of saturating agent 1.2g, scouring agent 1.6g, medium temperature amylase, bleeding agent CWA, scouring agent 120B are added to the water and are uniformly mixed
At treatment fluid；Then treatment fluid is warming up to 80 DEG C, it, finally will be in sink by alginate fibre in above-mentioned treatment fluid transfer 15
Treatment fluid release to get；
S2. fiber mix: by after pre-treatment alginate fibre and cotton fiber ratio 5:95 by weight mix；
S3. it weighs 2g composite fibre and is pressed into fibre strip layer, effective component is then sprayed at fibre strip layer surface,
Fountain height is the 20% of fibre strip layer quality, obtains the fibre strip layer with effective component after dry at 60 DEG C；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with band
There is the non-woven fabrics of effective component by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton
The exposed 8cm outside cotton core of line tail end；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, then will
It is placed in conduit to get tapon finished product；
Wherein, effective component includes the active constituent of following parts by weight: 6 parts of motherwort, 8 parts of wormwood, and 4 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 6
Part, 5 parts of rhizoma zingiberis；
The non-woven fabrics with effective component includes material composition sunflower fiber, viscose rayon, through following method system
It is standby to form:
Y1. it pre-processes:
Y11. the pretreatment of sunflower fiber: being added 1g/L sodium hydroxide solution, 50min then impregnated at 60 DEG C, bathes
Than for 1:10；
Y12. hot place the pretreatment of viscose rayon: is carried out in overflow dyeing machine using the sodium alkyl benzene sulfonate of 2wt.%
Reason, temperature are 95 DEG C, time 30min；
Y2. raw material mix: by pretreated sunflower fiber and viscose rayon on bale plucker according to spin require into
Row case is mixed, mixed proportion 5:95；
Y3. composite fibre is successively fiber spun-laced to get sunflower by combing, lapping, spun lacing, drying and coiling process
Non-woven fabrics；
Y31. carding step: fibrous raw material is processed into using double cylinder and double doffer carding machine be made of single fiber it is thin
Net, through cross lapping and drawing-off, to manufacture the fibre web of centainly quantitative three-dimensional disordered arrangements.
Y32. lapping process: by the way of cross lapping；Set the quantification of 36g/m of fibre web2, two layers fiber quantify
Respectively 18g/m2, the actual quantification of fibre web is 36g/m2。
Y33. rotary drum spun-laced machine, including 4 water jets spun lacing process: are used；Using 4 water jet processes, wherein the 1st
To the 4th spun lacing pressure successively are as follows: 15kg, 12kg, 26kg and 13kg.
Y34. drying process: controlling dry temperature is 110 DEG C.
Y4. micro emulsion is atomized: the fiber spun-laced non-woven fabrics of sunflower obtained using step Y3 is added 4 as carrier, by effective component
By high pressure nozzle jet atomization after the dilution of times ethanol solution, the Essence after atomization is under the high pressure draught effect of upper and lower convection current
It is evenly distributed on the fiber spun-laced non-woven fabrics of sunflower, atomization temperature is 18 DEG C, atomizing pressure 0.2MPa, air column jet air pressure
For 0.5MPa, the non-woven fabrics with effective component is obtained after sterile dry 12s at 62 DEG C.
Embodiment 2
The present embodiment provides a kind of preparation methods of tapon alleviate with gynecological disease, including following step
It is rapid:
S1. pre-treatment: alginate fibre being put in the water that temperature is 65 DEG C, and desizing enzyme 2.0g then is added by every liter of water, seeps
The proportion of saturating agent 1.5g, scouring agent 2.0g, medium temperature amylase, bleeding agent CWA, scouring agent 880 are added to the water and are uniformly mixed
At treatment fluid；Then treatment fluid is warming up to 85 DEG C, it, finally will be in sink by alginate fibre in above-mentioned treatment fluid transfer 15
Treatment fluid release to get；
S2. fiber mix: by after pre-treatment alginate fibre and cotton fiber ratio 18:82 by weight mix；
S3. it weighs 5g composite fibre and is pressed into fibre strip layer, effective component is then sprayed at fibre strip layer surface,
Fountain height is the 30% of fibre strip layer quality, obtains the fibre strip layer with effective component after dry at 65 DEG C；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with band
There is the non-woven fabrics of effective component by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton
The exposed 15cm outside cotton core of line tail end；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, then will
It is placed in conduit to get tapon finished product；
Wherein, effective component includes the active constituent of following parts by weight: 12 parts of motherwort, 2 parts of wormwood, and 9 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis
3 parts, 8 parts of rhizoma zingiberis；
The non-woven fabrics with effective component is prepared referring to the method in embodiment 1.
Embodiment 3
The present embodiment provides a kind of preparation methods of tapon alleviate with gynecological disease, including following step
It is rapid:
S1. pre-treatment: alginate fibre being put in the water that temperature is 62 DEG C, and desizing enzyme 1.6g then is added by every liter of water, seeps
The proportion of saturating agent 1.3g, scouring agent 1.8g, medium temperature amylase, bleeding agent CWA, scouring agent 880 are added to the water and are uniformly mixed
At treatment fluid；Then treatment fluid is warming up to 83 DEG C, it, finally will be in sink by alginate fibre in above-mentioned treatment fluid transfer 14
Treatment fluid release to get；
S2. fiber mix: by after pre-treatment alginate fibre and cotton fiber ratio 10:90 by weight mix；
S3. it weighs 4g composite fibre and is pressed into fibre strip layer, effective component is then sprayed at fibre strip layer surface,
Fountain height is the 24% of fibre strip layer quality, obtains the fibre strip layer with effective component after dry at 62 DEG C；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with band
There is the non-woven fabrics of effective component by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton
The exposed 10cm outside cotton core of line tail end；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, then will
It is placed in conduit to get tapon finished product；
Wherein, effective component includes the active constituent of following parts by weight: 10 parts of motherwort, 4 parts of wormwood, and 7 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis
4 parts, 6 parts of rhizoma zingiberis；
The non-woven fabrics with effective component is prepared referring to the method in embodiment 1.
Embodiment 4
The present embodiment provides a kind of preparation methods of tapon alleviate with gynecological disease, including following step
It is rapid:
S1. pre-treatment: alginate fibre being put in the water that temperature is 64 DEG C, and desizing enzyme 1.8g then is added by every liter of water, seeps
The proportion of saturating agent 1.4g, scouring agent 1.9g, medium temperature amylase, bleeding agent CWA, scouring agent 120B are added to the water and are uniformly mixed
At treatment fluid；Then treatment fluid is warming up to 82 DEG C, it, finally will be in sink by alginate fibre in above-mentioned treatment fluid transfer 13
Treatment fluid release to get；
S2. fiber mix: by after pre-treatment alginate fibre and cotton fiber ratio 15:85 by weight mix；
S3. it weighs 3g composite fibre and is pressed into fibre strip layer, effective component is then sprayed at fibre strip layer surface,
Fountain height is the 28% of fibre strip layer quality, obtains the fibre strip layer with effective component after dry at 64 DEG C；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with band
There is the non-woven fabrics of effective component by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton
The exposed 14cm outside cotton core of line tail end；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, then will
It is placed in conduit to get tapon finished product；
Wherein, effective component includes the active constituent of following parts by weight: 11 parts of motherwort, 6 parts of wormwood, and 5 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis
5 parts, 7 parts of rhizoma zingiberis；
The non-woven fabrics with effective component is prepared referring to the method in embodiment 1.
Comparative example 1
The process conditions of comparative example 1 are similar to Example 4, the difference is that, pre-treatment is not carried out to alginate fibre.
Comparative example 2
The process conditions of comparative example 2 are similar to Example 4, the difference is that, only with cotton fiber conduct in step S3
Fibrous raw material is pressed into fibre strip layer.
Comparative example 3
The process conditions of comparative example 3 are similar to Example 4, the difference is that not in fibre strip layer surface in step S3
Spray effective component.
Comparative example 4
The process conditions of comparative example 4 are similar to Example 4, the difference is that the effective component in step S3 is female without benefit
Grass.
Comparative example 5
The process conditions of comparative example 5 are similar to Example 4, the difference is that will be empty using common non-woven fabric in step S4
Heart sliver tight is at hollow tampon body.
Bacteriostasis rate detection is carried out to the tapon that the embodiment of the present invention 1~4 and comparative example 1~5 are prepared, together
When, using commercially available common tapon as blank control group, Escherichia coli, golden yellow grape are carried out to tapon sample obtained
The streptococcic bacteriostasis rate test of coccus, Candida albicans, Pseudomonas aeruginosa, beta hemolysis, the results are shown in Table 1.
Table 1
As the result is shown: the tapon and 1~5 method of comparative example being prepared by 1~4 method of the embodiment of the present invention are made
Sample, have a degree of fungistatic effect, obtained health after the surface layer of sanitary napkin be directly applied to pure-cotton fabric
Towel sample, no fungistatic effect.Wherein in the present invention, the fungistatic effect of Examples 1 to 4 relative to comparative example 2 and comparative example 4 compared with
It is good, but difference is unobvious；It is obvious relative to comparative example 1, comparative example 3 and comparative example 5, good antimicrobial effect, difference.
Microbial indicators detected
Microorganism is carried out to the tapon alleviate with gynecological disease that the preparation method of Examples 1 to 4 obtains
Indexs measure, microbiological indicator are measured according to standard GB/T/T 15979.It the results are shown in Table 2.
Table 2
Skin irritation test
The irritation of skin is carried out to the tapon of Examples 1 to 4 the method preparation and allergic reaction is tested, is
It evaluates its safety and reference is provided.
(1) skin irritation test is carried out using rabbit, divides intact skin group and damage skin group, for 24 hours by rabbit before test
Back backbone diamond wool shaves off, and after being kept in contact 1d, continuous 7d with tapon and rabbit skin and mucosa respectively, observation skin has
Without stimulate the reactions such as erythema, oedema.
(2) skin allergy experiment is carried out using cavy, is kept in contact 2 times with tapon and guinea pig skin mucous membrane weekly,
Contact 4h or more every time, continuous 5 weeks, whether there is or not the allergic reactions such as erythema, oedema for observation skin.
Experimental result:
The intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, respectively at 1,24,48,
72h observation, is showed no erythema and oedema, and stimulate the reaction mean scores are < 0.5, nonirritant.
In guinea pig skin allergic experiment, does not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other are systemic
Allergic reaction.
Therefore, tapon of the invention will not cause irritative response to rabbit intact skin and damage skin, to globefish
Mouse skin has good cutaneous safety without allergic reaction.
Vaginal irritation experiment
To the tapon of embodiment 1 and embodiment 4 and comparative example 2, comparative example 3 and the preparation of 5 the method for comparative example
Vaginal irritation effects experiment detection is carried out, and is arranged using commercially available common tapon as a control group, specific experimental method is as follows:
SD rat is taken, female, regular grade, 220~240g of weight is randomly divided into 6 groups, every group 4.Referring to disinfection technology standard (third
Version) 3.8 in 1999.11, tapon is placed in animal intravaginal, contacts 2h with vagina mucosa, is put to death after 12h dynamic
Object takes out vagina local organization, and whether there is or not congested, oedema phenomenons for observation, referring to skin in disinfection technology standard (third edition) 1999.11
The standards of grading of skin stimulate the reaction intensity score and skin irritatin strength grading, carry out the evaluation to vaginal mucosa irritation intensity.
Experimental result is shown in Table 3.
Table 3
Drug effect uses experiment
Selection has the patient of colpitis medical history totally 400 people, is randomly divided into 8 groups, every group of 50 people, respectively using embodiment 1,
Tapon prepared by embodiment 4 and comparative example 1~5, another 1 group uses commercially available common tapon, by three menstrual cycles
It uses, its experimental result is counted, result is as follows:
1,4 the influence to vulva pruritis: be the results are shown in Table
4 pruritus vulvue of table alleviates situation
As the result is shown: embodiment 1 has 43 people (74%) to have alleviation to vulva pruritis, and embodiment 4 has 42 people (84%)
There is alleviation to vulva pruritis, only 7 people have slight relief to vulva pruritis to control group, the results showed that the present invention is to vulva
There is preferable effect in terms of pruritis, effect is substantially better than the prior art.
2,5 the overall feeling after use: be the results are shown in Table
Feeling after 5 use of table
Embodiment 1 has 38 people (76%) comfortable with rear common sensation to table 5 as the result is shown, and embodiment 4 has 44 people (88%) use
Common sensation is comfortable afterwards, the results showed that the present invention is comfortable on after, can alleviate the symptoms such as dysmenorrhea, and comfort level is substantially better than existing
There is technology.
Obviously, above-described embodiment is only intended to clearly illustrate technical solution of the present invention example, and is not
Restriction to embodiments of the present invention.For those of ordinary skill in the art, on the basis of the above description also
It can make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all
Made any modifications, equivalent replacements, and improvements etc. within the spirit and principles in the present invention should be included in right of the present invention and want
Within the protection scope asked.
Claims (10)
1. a kind of preparation method of the tapon alleviate with gynecological disease, which comprises the following steps:
S1. pre-treatment: the fiber Jing Guo starching is handled at a certain temperature using desizing enzyme, bleeding agent and scouring agent；
S2. fiber mixes: by after pre-treatment alginate fibre and cotton fiber mix in specified weight ratio；
S3. the composite fibre for weighing fixed weight is pressed into fibre strip layer, and effective component is then sprayed at fibre strip layer
Surface obtains the fibre strip layer with effective component after dry；
S4. it prepares hollow tampon body: fibre strip lamination prepared by step S3 being made by hollow sliver using mold, with medicine
The non-woven fabrics of effect ingredient is by hollow sliver tight at hollow tampon body；
S5. cotton core is made in fibre strip lamination prepared by step S3, cotton thread is then fixed on cotton core centre, cotton thread tail
Hold the exposed certain length outside cotton core；
S6. the step S5 cotton core prepared is filled in the hollow tampon body of step S4, obtains tapon ontology, is then set
To get tapon finished product in conduit；
Wherein, the effective component includes following parts by weight of component: 6 ~ 12 parts of motherwort, 2 ~ 8 parts of wormwood, and 4 ~ 9 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis
3 ~ 6 parts, 5 ~ 8 parts of rhizoma zingiberis.
2. preparation method according to claim 1, which is characterized in that in step S1, the pre-treating method of alginate fibre are as follows: will
Alginate fibre puts temperature, then by every liter of water be added 1.5 ~ 2.0g of desizing enzyme, 1.2 ~ 1.5g of bleeding agent,
The proportion of 1.6 ~ 2.0 g of scouring agent, desizing enzyme, bleeding agent, scouring agent are added to the water and are mixed into treatment fluid；Then will
Treatment fluid is warming up to 80 ~ 85 DEG C, by alginate fibre in above-mentioned treatment fluid transfer 12 ~ 15, finally puts the treatment fluid in sink
Out to get.
3. preparation method according to claim 2, which is characterized in that the desizing enzyme is medium temperature amylase；The bleeding agent
For nonionic penetrant；The scouring agent is scouring agent 880 or scouring agent 120B.
4. preparation method according to claim 2, which is characterized in that 1.5 ~ 1.8 g of desizing enzyme, bleeding agent is added by every liter of water
1.2 ~ 1.4 g, 1.6 ~ 1.8 g of scouring agent.
5. preparation method according to claim 1, which is characterized in that in step S2, the weight of the alginate fibre and cotton fiber
Amount is than being 5 ~ 18:82 ~ 95；Preferably, the weight ratio of the alginate fibre and cotton fiber is 8 ~ 16:84 ~ 92.
6. preparation method according to claim 1, which is characterized in that in step S3, the fixed weight of the composite fibre is 2
~5 g；Preferably, the fixed weight of the composite fibre is 2 ~ 4 g；Preferably, the fixed weight of the composite fibre is 4 g.
7. preparation method according to claim 1, which is characterized in that in step S3, the effective component includes following weight
Part component: 10 ~ 12 parts of motherwort, 6 ~ 8 parts of wormwood, 4 ~ 6 parts of Radix Glycyrrhizae, 4 ~ 6 parts of Radix Angelicae Sinensis, 6 ~ 8 parts of rhizoma zingiberis.
8. preparation method according to claim 1, which is characterized in that in step S3, the fountain height of effective component is that strip is fine
The 20 ~ 30% of layer quality are tieed up, obtain the fibre strip layer with effective component after dry at 60 ~ 65 DEG C；Preferably, the medicine
The fountain height for imitating ingredient is the 20 ~ 28% of fibre strip layer quality, and drying temperature is 60 ~ 64 DEG C.
9. preparation method according to claim 1, which is characterized in that in step S4, the non-woven fabrics with effective component
Including material composition sunflower fiber, viscose rayon, it is prepared through following method:
Y1. it pre-processes:
Y11. the preprocess method of sunflower fiber are as follows: 1 ~ 5 g/L soda ash solution is added, 50 ~ 60 are then impregnated at 50 ~ 60 DEG C
Min, bath raio are 1:5 ~ 10；
Y12. the preprocess method of viscose rayon are as follows: be heat-treated in overflow dyeing machine using the emulsifier of 1 ~ 3wt.%, temperature
Degree is 90 ~ 95 DEG C, and the time is 20 ~ 40 min；
Y2. raw material mixes: pretreated sunflower fiber and viscose rayon ratio 5 ~ 20:80 ~ 95 by weight are mixed；
Y3. by composite fibre successively by combing, lapping, spun lacing, drying and coiling process to get the fiber spun-laced nonwoven of sunflower
Cloth；
Y4. micro emulsion be atomized: the fiber spun-laced non-woven fabrics of sunflower obtained using step Y3 as carrier, by above-mentioned effective component be added 2 ~
By high pressure nozzle jet atomization after 5 times of organic solvent dilutings, the Essence after atomization is acted in the high pressure draught of upper and lower convection current
Under be evenly distributed on the fiber spun-laced non-woven fabrics of sunflower, after sterile drying obtain have effective component non-woven fabrics.
10. what any one preparation method was prepared according to claim 1 ~ 9 has effects that alleviate the health of gynecological disease
Sliver.
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| CN111991609A (en) * | 2019-05-27 | 2020-11-27 | 苏州宝丽洁医疗科技有限公司 | Production process of tampon added with medicinal ingredients |
| WO2024038205A1 (en) * | 2022-08-19 | 2024-02-22 | Vyld Gmbh | Alginate tampon and production method |
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