CN105616294B - It is a kind of that there is antibacterial, disinfection liquid and its application - Google Patents
It is a kind of that there is antibacterial, disinfection liquid and its application Download PDFInfo
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- CN105616294B CN105616294B CN201610081911.0A CN201610081911A CN105616294B CN 105616294 B CN105616294 B CN 105616294B CN 201610081911 A CN201610081911 A CN 201610081911A CN 105616294 B CN105616294 B CN 105616294B
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- towel
- alcohol extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
- A47K10/00—Body-drying implements; Toilet paper; Holders therefor
- A47K10/16—Paper towels; Toilet paper; Holders therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H17/00—Non-fibrous material added to the pulp, characterised by its constitution; Paper-impregnating material characterised by its constitution
- D21H17/02—Material of vegetable origin
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21H—PULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
- D21H21/00—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
- D21H21/14—Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
- D21H21/36—Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
Abstract
There is antibacterial, disinfection liquid and its application the present invention relates to a kind of, the liquid includes the active constituent of following parts by weight：8 12 parts of Cortex Magnoliae Officinalis alcohol extract, 12 18 parts of Fructus cnidii, 10 15 parts of climbing groundsel alcohol extract, 6 10 parts of usnic acid.The active constituent of liquid of the present invention is natural extract, and biodegradability is good, and environment is not polluted；And property is mild, and it is skin friendly, it is nonirritant, there is ideal antibacterial, sterilization and antiinflammation.Liquid of the present invention has broad application prospects in hygienic articles, especially in the application of towel of going to the lavatory (wet tissue, dry towel), embodies ideal antibacterial, sterilization and anti-inflammatory effects.
Description
Technical field
There is antibacterial, disinfection liquid, while be related to above-mentioned liquid and preparing hygienic articles the present invention relates to a kind of
In application.
Background technology
As masses aggravate the attention degree of personal hygiene, with antibacterial, disinfection hygienic articles at present
As much-sought-after item.Such as：
Chinese patent CN1062467C discloses a kind of clean-preserving agent, is 1-3% by weight ratio0Borneol, crude drug in whole contains
Measure as every milliliter 0.3-0.5 grams, alcohol that remaining is 10-15% concentration composition, crude drug in whole include climbing groundsel, the root bark of shaggy-fruited dittany, it is windproof,
Folium artemisiae argyi, frutus cnidii, Chinese gall add in borneol during preparation, after primary medicinal alcohol is soaked, leaked and can be prepared by.By above-mentioned guarantor
Clean dose is penetrated into first woven fabric and can be made into moist-retaining tissues, can be used in preventing and treating skin disease and gynaecological disease.
Although above-mentioned clean-preserving agent has preferable antibacterial, disinfection and antiinflammation, found in practical application, exist with
Lower Railway Project：
1) women is small after an action of the bowels, and private parts since there are urine lefts, needs to inhale using the excellent paper handkerchief of the water imbibition of dry state in itself
Urine, clean is received, and the small requirement for absorbing urine cleaning private parts after an action of the bowels is not achieved in wet tissue.
2) borneol has refrigerant experience sense, and human body is also easy to produce dependence, and the reproductive system for being harmful to women is used for a long time
Health.
China application CN 104013558A disclose a kind of wet tissue sterilization and anticorrosion compositional liquor, preparation method and its usage.Institute
State material composition of the wet tissue sterilization and anticorrosion compositional liquor by following weight percentage:16 a heatable brick bed base pyridinium chloride 4-15%；Solvent 10-
30%；Solubilizer 5-20%；3 p-chlorophenyl -1,2 propylene glycol 2%-10%；Chamomile extracting solution 0.02%-1.5%；Aloe
Extracting solution 0.02%-1.5%；Appropriate citric acid, remaining is RO water.This application points out, the wet tissue sterilization and anticorrosion compositional liquor of gained
Mildly nothing irritates the wet tissue being prepared after dilution, harmless, and with sterilization, conditioning improves skin properties, to skin
Comfort reaches optimum efficiency, both will not be too viscous, will not be too dry, there is skin-moisturizing, skin antioxidation.However, in practical application
Middle discovery, the application range of above-mentioned sterilization and anticorrosion compositional liquor is relatively narrow, preferable can not especially go to the lavatory towel for women.
Therefore, need to be proposed a kind of antibacterial, significant liquid of disinfection, in order to make hygienic articles, especially female
Sex hygiene product (towel of such as going to the lavatory).
Invention content
To overcome the above disadvantages, there is antibacterial, disinfection liquid the present invention provides a kind of；The liquid includes
The active constituent of following parts by weight：8-12 parts of Cortex Magnoliae Officinalis alcohol extract, 12-18 parts of Fructus cnidii, climbing groundsel alcohol extract 10-15
Part, 6-10 parts of usnic acid.
One kind in μ g, mg, g, kg that above-mentioned parts by weight are known in the art is its multiple, such as 1/100,1/10,10
Times, 100 times etc..
Preferably, the liquid includes the active constituent of following parts by weight：10 parts of Cortex Magnoliae Officinalis alcohol extract, Fructus cnidii 15
Part, 12 parts of climbing groundsel alcohol extract, 8 parts of usnic acid.
Liquid of the present invention provides active constituent, wherein Cortex Magnoliae Officinalis with Cortex Magnoliae Officinalis, frutus cnidii, climbing groundsel, usnic acid combination
Alcohol extract main component is magnolol, and Fructus cnidii main component is Osthole, and climbing groundsel alcohol extract main component is
Senecionine, above-mentioned active constituent and usnic acid compatibility, it is ensured that quality of liquid medicine.
Ordinary commercial products can be used in above-mentioned active constituent, in order to ensure antibacterial, disinfection the effect of liquid, the present invention
The Cortex Magnoliae Officinalis alcohol extract, Fructus cnidii, climbing groundsel alcohol extract preferably extract to obtain (usnic acid by methods described below
Can be directly commercially available, such as it is purchased from Si Mei springs bio tech ltd).
Cortex Magnoliae Officinalis alcohol extract be after Cortex Magnoliae Officinalis is crushed with after ethanol solution alcohol extracting through being concentrated to give.
Specifically, the extracting method of the Cortex Magnoliae Officinalis alcohol extract is as follows：By Cortex Magnoliae Officinalis fruit grinding and sieving (preferably 30 mesh sieve),
It is extracted 2-4 times at 55-65 DEG C with the 50-70% ethyl alcohol for being equivalent to 8-12 times of its quality, extraction time is every time 1-3h, respectively
Merge extracting solution and be condensed into medicinal extract (medicinal extract that preferably relative density is 1.1-1.3)；
It is preferred that Cortex Magnoliae Officinalis fruit is smashed it through 30 mesh sieve, extracted at 60 DEG C with 60% ethyl alcohol for being equivalent to 10 times of its quality
3 times, extraction time is respectively 2h, 1.5h, 1h, merges extracting solution respectively and is condensed into the medicinal extract that relative density is 1.1-1.3, i.e.,
.
Using said extracted method, it can greatly improve the recovery rate of active ingredient magnolol, so that suppression in prescription
Bacterium bactericidal effect is also improved simultaneously.
The extracting method of the Herba Senecionis Scandentis extract is as follows：Climbing groundsel is put in 55-65 DEG C of insulating box dry 0.5-2h,
Grinding and sieving (preferably 30 mesh sieve)；With the 50-70% ethyl alcohol for being equivalent to 10-14 times of its quality 2-4 is extracted at 55-65 DEG C
Secondary, extraction time is every time 1-3h, merges extracting solution respectively and is condensed into medicinal extract (preferably leaching of the relative density for 1.1-1.3
Cream)；
It is preferred that climbing groundsel is put in 60 DEG C of insulating boxs dry 1h, 30 mesh sieve is smashed it through；With being equivalent to 12 times of its quality
60% ethyl alcohol extracts 3 times at 60 DEG C, and extraction time is respectively 2h, 1.5h, 1h, merges extracting solution respectively and is condensed into relatively close
Spend the medicinal extract for 1.1-1.3 to get.
Using said extracted method, it can greatly improve the recovery rate of active ingredient senecionine, other have antibacterial work(
The phenolic acid compound recovery rate of effect can also be promoted so that the restraining and sterilizing bacteria effect in prescription is also improved simultaneously.
The extracting method of the Fructus cnidii is as follows：
Frutus cnidii is put into baking oven, is dried under the drying temperature no more than 60 DEG C；Through grinding and sieving after drying
(preferably 30 mesh sieve)；Fine powder after crushing is imported in extractor, extracting pressure 20-30MPa, 40-45 DEG C of temperature, flow velocity are set
Primary oil is received in control in 25~45L/h, per half an hour, until no volatile oil extract to get；
It is preferred that the fine powder after crushing is imported in extractor, extracting pressure 25MPa is set, and 42 DEG C of temperature, flow control exists
30~40L/h receives primary oil per half an hour, until no volatile oil extract to get.
Liquid of the present invention in addition to above-mentioned active constituent, still further comprises solvent, i.e., described liquid by activity into
Dispersion is formed in a solvent, and the dosage of preferably described solvent is 200-900 parts by weight.
Specifically, liquid of the present invention is using ethanol water, water, glycerine or propylene glycol etc. as solvent, more to have
Conducive to dispersion of active ingredients, it is ensured that the quality of liquid.
When the solvent is ethanol water, volumetric concentration is advisable in 50-75%, preferably 60-70%.
Spice additive is further included in liquid of the present invention, the odor additive includes pure natural spice or artificial fragrant
Material.
Wherein, the pure natural spice is selected from one or more of elscholtiza, borneol, oriental wormwood, peppermint hydrosol and yellow wormwood artemisia；Institute
It states plants essential oil and is selected from Chinese torreya essential oil, mother chrysanthemum flower essential oil, daphne odera essential oil, pinecone essential oil, mugwort oil, thyme essential oil, You Jia
One or more of sharp essential oil, tea tree ethereal oil and camphor tree essential oil.
Preferably, various plants essential oils and chemical synthesis essence, especially Elsholtzia cilita essential oil, argy wormwood may be selected in the artificial flavors
Oil, daphne odera essential oil and camphor tree essential oil, such essential oil is preferably to add in liquid of the present invention, further to adjust gas
Taste increases effect.
The dosage of above-mentioned spice additive, which is subject to, can make the liquid form pleasant fragrance, when selection plants essential oil
When, ideal dosage is 0.1%-0.3%, can specifically be adjusted according to actual conditions.
Invention also provides application of the above-mentioned liquid in hygienic articles are prepared.
Above-mentioned hygienic articles include wet tissue or dry towel, preferably go to the lavatory towel, sanitary napkin or disinfecting paper etc., towel of more preferably going to the lavatory.
For towel of the present invention of going to the lavatory for wet tissue or dry towel, the base fabric is selected from non-woven fabrics or domestic paper, the domestic paper
It is preferred that wettable domestic paper.Wherein, domestic paper refers to paper for daily use, refer to for look after it is personal at home, it is outgoing wait used in all kinds of defend
Raw wiping paper including roll toilet paper, extraction-type toilet paper, Boxed facial tissue, pocket face-tissue, paper handkerchief, napkin paper, wipes hand
Paper, kitchen towels.Wettable domestic paper refers to that wet strength is preferable in domestic paper, can at home wipe and not allow in the case where getting wet
Easily rupturable paper.
When the towel of going to the lavatory is wet tissue, non-woven fabrics or domestic paper may be selected in the base fabric, i.e., the liquid is infiltrated institute
Towel wet tissue of going to the lavatory can be obtained by stating base fabric.This field conventional technology can be used in the preparation method for towel wet tissue of going to the lavatory, in order to
The towel wet tissue of going to the lavatory of best results is obtained, the present invention is preferably during towel wet tissue is gone to the lavatory in infiltration, and liquid is with respect to the use of base fabric
It measures as 4-6ml/g, after infiltration, drains the moisture for towel of going to the lavatory, reach the wet tissue water content of this field routine.For
Liquid is made preferably to play antibacterial, disinfection, the infiltration amount of the preferred control final products Chinese medicine liquid of the present invention is 4.5-
5.5g/g it is advisable.
When the towel of going to the lavatory is dry towel, domestic paper may be selected in the base fabric, the needle slurry of preferably described domestic paper
For usage amount more than 85%, moisture is less than 9.0%.
Alternatively, the index of the ideal domestic paper at least meets 3 of following index or more (preferably meeting)：Thickness
For 0.05-0.07mm, longitudinal dry tensile strength is 2000-3200mN, and lateral dry tensile strength is 290-370mN, elongation 9%-11%,
2mm~5mm hole eyes number≤6/㎡, individual layer transverse direction suction range are not less than 20mm/100s, and double-deck transverse direction suction range is not less than
40mm/100s。
Preferably, the thickness of the wettable domestic paper is 0.05-0.06mm, and longitudinal dry tensile strength is 2480-3000mN,
Lateral dry tensile strength is 290-320mN, the Ge/㎡ of elongation 10%-11%, 2mm~5mm hole eye number≤6, individual layer transverse direction suction range
Not less than 20mm/100s, double-deck transverse direction suction range is not less than 40mm/100s.
The life stationery base fabric that the present invention can select further includes such as permanent wettable water paper handkerchief of peace product promise.
The present invention goes to the lavatory the medicine liquid spray the dry towel of towel to obtain the final product in base fabric (and can be described as body paper), the specific spray of liquid
The amount of spilling can be by those skilled in the art according to the conventional selection of this field, according to depending on actual conditions, and liquid of the present invention exists
Fountain height in base fabric is preferably 0.006-0.008ml/g, and what this fountain height was prepared go to the lavatory, and towel medicine liquid spray is uniform, humidity
It is suitable, it is easy to use.
In addition, above-mentioned base fabric has preferably covered one layer of smears, such base fabric softness moisturizing, while water imbibition on its surface
It is good, more skin-friendly strong with the towel water lock ability of going to the lavatory that this base fabric is prepared.The smears may be selected from commonly used in the art
Substance in order to enable smears can preferably coordinate with liquid described herein, plays best effect, the present invention is preferably
Above-mentioned smears is one or more in moisturizer, softening agent, creams, and (smears is opposite for its further preferred coating weight
In the mass percent dosage of base fabric) it is 18-25%.Wherein, the moisturizer be selected from glycerine, polyglycereol, transparent Bronsted acid sodium,
One or more of aloe extract.
Invention also provides the preparation method of above-mentioned towel of going to the lavatory, as one of technical scheme of the present invention, when described
When towel of going to the lavatory is wet tissue, preparation method specifically comprises the following steps：
(1) 8-12 parts of Cortex Magnoliae Officinalis alcohol extract, 12-18 parts of Fructus cnidii, 10-15 parts of climbing groundsel alcohol extract, usnic acid are taken
It is 6-10 parts, spare；
(2) each component in step (1) is dissolved in partial solvent and be dissolved in partial solvent, stirred evenly；
(3) step (2) acquired solution is filtered, deposit is removed, takes supernatant, further add solvent thereto, it is fixed
Hold to 700-900 parts；Or it is further added in the supernatant and adds solvent constant volume again after spice additive and disappear to get antibacterial
Poison liquid；
(4) by it is described it is antibacterial disinfection liquid infiltration base fabric to get.
Preferably, step (4) Chinese medicine liquid is 4-6ml/g with respect to the dosage of base fabric.
Preferably, the solvent is 50-75% ethanol solutions or water.
Wherein, step (2) is predissolve step, and the 8-12% of the partial solvent preferred solvent total volume, predissolve has
Help the abundant dissolving of active constituent, improve the quality of liquid.
As another technical solution of the present invention, when described towel of going to the lavatory is dry towel, preparation method specifically include as
Lower step：
(1) 8-12 parts of Cortex Magnoliae Officinalis alcohol extract, 12-18 parts of Fructus cnidii, 10-15 parts of climbing groundsel alcohol extract, usnic acid are taken
It is 6-10 parts, spare；
(2) each component in step (1) is dissolved in partial solvent and be dissolved in partial solvent, stirred evenly；
(3) step (2) acquired solution is filtered, deposit is removed, takes supernatant, further add solvent thereto, it is fixed
Hold to 200-400 parts；Or it is further added in the supernatant and adds solvent constant volume again after spice additive and disappear to get antibacterial
Poison liquid；
(4) by it is described it is antibacterial disinfection liquid be sprayed at scrim surfaces to get.
Fountain height of the liquid of the present invention in base fabric is preferably 0.006-0.008ml/g,
Preferably, the solvent is 50-75% ethanol solutions or glycerine.
Step (2) is predissolve step, and the 8-12% of the partial solvent preferred solvent total volume, predissolve helps to live
The abundant dissolving of property ingredient improves the quality of liquid.
At present, life paper conversion mainly includes two processes：Preceding processing and post-processing.Preceding processing refers to body paper production, rear to add
Work refer to the body paper after cutting is embossed, the processing such as Amscomatic.The present invention is in order to enable final products are more soft wet
Profit, pro-skin sense is stronger, and each layer of paper handkerchief is tightly combined, easy to use, in this application, has been especially added with completely new middle processing skill
Art, which is to carry out roller coating or spray treatment to body paper using smears before post-processing, in addition, changing existing
" being first embossed, rear to fold " mode, using completely new " first folding, rear to be embossed " pattern.
Concrete operations are：In step (4), first base fabric is coated using smears, is then cut into base fabric specified
Breadth, then folded, be embossed, fold and embossing process in described antibacterial will sterilize liquid or antibacterial disinfection liquid
The surface of base fabric is sprayed on fragrance, finally product is packed, is sterilized.
The specification of towel of the present invention of going to the lavatory can be adjusted according to actual conditions, and optimal size is：10cm × 14cm, thickness
16 layers, white embossing has the fragrance tasteless, the fragrant and a variety of different type of Chinese medicine is light.
Liquid of the present invention has the following advantages：
(1) four kinds of Magnolia cortex P.E in the present invention, Herba Senecionis Scandentis extract, common cnidium fruit P.E, usnic acid ingredient combinations
It uses, there is heat-clearing and damp-drying drug, eliminate dampness with aromatics, restraining and sterilizing bacteria, can prevent microorganism infection, when use has cleaning, comfortable, health care
Effect.
(2) liquid of the invention tool is antibacterial, sterilization and antiinflammation, to skin and vaginal mucosa without any irritation and
Side effect, fragrant odour.
(3) using liquid of the present invention prepare go to the lavatory towel soft comfortable, good water absorption, fungistatic effect significantly and have
The features such as easily disperse.
(4) the advantages that liquid of the present invention and towel of going to the lavatory are provided with of low cost, long shelf-life, high stability.
Description of the drawings
Fig. 1 is the preparation technology flow chart of towel dry towel of the invention of going to the lavatory.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
All raw materials of the present invention are known commercially available product, and the detection method being related to or operation are such as without special
Explanation is the common detection methods or operation of this field.Cortex Magnoliae Officinalis alcohol extract, Herba Senecionis Scandentis extract involved in following embodiment,
Fructus cnidii extracts by the following method.
Cortex Magnoliae Officinalis alcohol extract：Cortex Magnoliae Officinalis fruit is smashed it through into 30 mesh sieve, with being equivalent to 60% ethyl alcohol of 10 times of its quality 60
It is extracted 3 times at DEG C, extraction time is respectively 2h, 1.5h, 1h, merges extracting solution respectively and is condensed into relative density as 1.1-1.3
Medicinal extract to get.
Herba Senecionis Scandentis extract：Climbing groundsel is put in 60 DEG C of insulating boxs dry 1h, smashes it through 30 mesh sieve；With being equivalent to it
12 times of 60% ethyl alcohol of quality extracts 3 times at 60 DEG C, and extraction time is respectively 2h, 1.5h, 1h, merges extracting solution respectively and concentrates
Into relative density be 1.1-1.3 medicinal extract to get.
Fructus cnidii：Frutus cnidii is put into baking oven, is dried under the drying temperature no more than 60 DEG C；After drying
30 mesh sieve is crossed after crushed, and the fine powder after crushing is imported in extractor, sets extracting pressure 25MPa, 42 DEG C of temperature, flow control
In 30~40L/h, primary oil is received per half an hour, until no volatile oil extract to get.
Although a kind of above-mentioned specific embodiment for being only exemplified by each extract, it will be appreciated by those skilled in the art that
Be be not limited to other extracting methods (method especially in the range of the present invention limits) of ad hoc fashion similarly can be with
It realizes essentially identical extraction effect, available for realizing the present invention, this is no longer particularly limited.
Only as explaining, such as Cortex Dictamni extract obtained may be equally applied to the present invention in accordance with the following methods：
Cortex Magnoliae Officinalis alcohol extract：Cortex Magnoliae Officinalis fruit is smashed it through into 30 mesh sieve, with 50% ethyl alcohol for being equivalent to its quality 8 or 12 times
(or 70%) extracts 2-4 times under 65 DEG C (or 55 DEG C), and extraction time is respectively 3h, 1.5h, 1.5h, merges extracting solution simultaneously respectively
Be condensed into relative density be 1.1-1.3 medicinal extract to get.
The parameter of wettable domestic paper used in following embodiment is as follows：Thickness is 0.05-0.06mm, longitudinal dry tensile strength
For 2480-3000mN, lateral dry tensile strength is 290-320mN, elongation 10%-11%, 2mm~5mm hole eye number≤6 Ge/㎡, single
The lateral suction range of layer is not less than 40mm/100s not less than 20mm/100s, double-deck transverse direction suction range.
It will be appreciated by persons skilled in the art that in addition to above-mentioned preferred wettable domestic paper, other suitable paper products can
It is equally used for realizing the present invention.
Embodiment 1
Present embodiments provide it is a kind of there is antibacterial, disinfection liquid, the specific prescription of the liquid is as follows：Cortex Magnoliae Officinalis
8 parts of alcohol extract, 12 parts of Fructus cnidii, 10 parts of climbing groundsel alcohol extract, 6 parts of usnic acid, 1 part of daphne odera essential oil, 800 parts of water.
Embodiment 2
It present embodiments provides a kind of with antibacterial, disinfection liquid；The specific prescription of the liquid is as follows：Cortex Magnoliae Officinalis
10 parts of alcohol extract, 15 parts of Fructus cnidii, 12 parts of climbing groundsel alcohol extract, 8 parts of usnic acid, 1 part of daphne odera essential oil, 60% ethyl alcohol
300 parts.
Embodiment 3
It present embodiments provides a kind of with antibacterial, disinfection liquid；The specific prescription of the liquid is as follows：Cortex Magnoliae Officinalis
12 parts of alcohol extract, 18 parts of Fructus cnidii, 15 parts of climbing groundsel alcohol extract, 10 parts of usnic acid, 300 parts of glycerine.
Embodiment 4
It present embodiments provides a kind of with antibacterial, disinfection liquid；The specific prescription of the liquid is as follows：Cortex Magnoliae Officinalis
10 parts of alcohol extract, 16 parts of Fructus cnidii, 15 parts of climbing groundsel alcohol extract, 9 parts of usnic acid, 70% 300 parts of ethyl alcohol.
Embodiment 5
A kind of method for preparing and there is antibacterial, disinfection towel of going to the lavatory described in embodiment 1 is present embodiments provided, specifically
Include the following steps：
(1) Cortex Magnoliae Officinalis alcohol extract, climbing groundsel alcohol extract, Fructus cnidii, usnic acid are dissolved in 80 parts of water, stirring is equal
It is even；
(2) step (1) acquired solution is filtered, deposit is removed, takes supernatant, adds in daphne odera essential oil thereto, so
After add remaining water, be uniformly mixed up to antibacterial disinfection liquid；
(3) the antibacterial disinfection liquid infiltration is cut into the non-woven fabrics of suitable dimension, is packed to obtain the final product.
Wherein, go to the lavatory towel Chinese medicine liquid infiltration amount be 4-6g/g.
Embodiment 6
A kind of method for preparing and there is antibacterial, disinfection towel of going to the lavatory described in embodiment 2 is present embodiments provided, specifically
Include the following steps (as shown in Figure 1)：
(1) Cortex Magnoliae Officinalis alcohol extract, climbing groundsel alcohol extract, Fructus cnidii, usnic acid are dissolved in 30 part of 60% ethyl alcohol, stirred
It mixes uniformly；
(2) step (1) acquired solution is filtered, deposit is removed, takes supernatant, adds in daphne odera essential oil thereto, is mended
Add remaining ethyl alcohol, be uniformly mixed up to antibacterial disinfection liquid；
(3) first wettable domestic paper (and can claim body paper) is coated with using rolling method using glycerine (quantity for spray 20%), then
Paper product is cut into 10cm × 14cm breadth, is then folded, is embossed, by the antibacterial disinfection in folding and embossing process
Liquid (fountain height 0.006-0.008ml/g) is sprayed on the surface of paper product, finally product is packed, ethylene oxide sterilizing
To obtain the final product.
Embodiment 7
A kind of method for preparing and there is antibacterial, disinfection towel of going to the lavatory described in embodiment 3 is present embodiments provided, specifically
Include the following steps：
(1) Cortex Magnoliae Officinalis alcohol extract, climbing groundsel alcohol extract, Fructus cnidii, usnic acid are dissolved in 36 parts of glycerine, stirred
Uniformly；
(2) step (1) acquired solution is filtered, deposit is removed, takes supernatant, add remaining glycerine, is uniformly mixed
Up to antibacterial disinfection liquid；
(3) first wettable domestic paper using rolling method is coated with using polyglycereol (coating weight 18%), then cuts paper product
It into 10cm × 14cm breadth, then folded, be embossed, be sprayed on the antibacterial disinfection liquid in embossing process folding
The surface (fountain height 0.006-0.008ml/g) of paper product, finally product is packed, ethylene oxide sterilizing to obtain the final product.
Embodiment 8
A kind of method for preparing and there is antibacterial, disinfection towel of going to the lavatory described in embodiment 4 is present embodiments provided, specifically
Include the following steps：
(1) Cortex Magnoliae Officinalis alcohol extract, climbing groundsel alcohol extract, Fructus cnidii, usnic acid are dissolved in 24 part of 70% ethyl alcohol, stirred
It mixes uniformly；
(2) step (1) acquired solution is filtered, deposit is removed, takes supernatant, add remaining ethyl alcohol, is uniformly mixed i.e.
Obtain antibacterial disinfection liquid；
(3) first wettable domestic paper is used using softening agent SME-4 (polyoxyethylene stearic acid ester, coating weight 25%) and sprayed
Method is coated with, and paper product then is cut into 10cm × 14cm breadth, is then folded, is embossed, will in folding and embossing process
The antibacterial disinfection liquid is sprayed on the surface (fountain height 0.006-0.008ml/g) of paper product, and finally product is packed, is gone out
Bacterium to obtain the final product.
Below by way of fungistatic effect, stability for testing liquid of the present invention and towel of going to the lavatory etc., the present invention is protected
Technical solution be further described.
One fungistatic effect of experimental example is tested
1st, liquid fungistatic effect is tested
1.1 experiment reagents (refer to table 1)：
Table 1：
Licorice, camomile extract and aloe extract etc. can be right by commercially available in above-mentioned control group
Preparation according to Fructus Gleditsiae Abnormalis extract in group 6 can refer to China application CN103340816.
1.2 experimental method
Experimental strain：Staphylococcus aureus, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, hemolytic streptococcus；Tool
Body experimental procedure refers to《15979-2002 disposable sanitary articles sanitary standards》Regulation.
1.3 experimental result
Experimental result is shown in Table 2：
Table 2：Bacteriostasis rate (%)
Above-mentioned experiment is repeated with the liquid of other embodiment of the present invention, obtains essentially identical experiment conclusion.
2nd, wet tissue fungistatic effect is tested
2.1 experiment reagents (refer to table 3)：
Table 3：
| Experimental group 1 | 5 preparation-obtained wet tissue of embodiment (the infiltration amount of liquid is 5g/g, and liquid formula is with embodiment 1) |
| Compare blank group | Wet tissue preparation method is differed only in experimental group 1：Non-woven fabrics is infiltrated using physiological saline |
| Control group 1 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 1 |
| Control group 2 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 2 |
| Control group 3 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 3 |
| Control group 4 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 4 |
| Control group 5 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 5 |
| Control group 6 | Wet tissue preparation method is differed only in experimental group 1：Using the active constituent of control group 6 |
2.2 experimental method：
With 1.2.
2.3 experimental result
Experimental result refers to table 4.
Table 4：Bacteriostasis rate (%)
3rd, dry towel fungistatic effect experiment
3.1 experiment reagents (refer to table 5)：
Table 5：
3.2 experimental method：With 2.2；
3.3 experimental result
Experimental result refers to table 6.
Table 6：Bacteriostasis rate (%)
4th, wet tissue and the experiment of the long-time stability of dry towel
Experimental subjects：The table 3 after 3,6,12 and 24 months and the wet tissue in table 5 and dry towel are placed after preparation respectively；
Experimental method：With 2.2 and 3.2；
Experimental result is shown in Table 7.
Table 7：Bacteriostasis rate (%)
Two wet tissue of experimental example, dry towel skin irritation test
Laboratory sample：Dry towel in wet tissue and table 2 in table 1
Experimental method：Rabbit back spinal diamond wool is cut for 24 hours before experiment, unhairing range or so is to 5cm × 5cm, and one
For testing, skin is cleaned in side for compareing, using warm water for side, then wipes laboratory sample on a side test skin,
Wiping 1 time daily, 1h observes skin wound repair after wiping, and continuous wiping 30 days records experimental result.
Experimental result：As shown in table 8.
8 skin irritation test result of table：
Three wet tissue of experimental example, the experiment of dry towel vaginal irritation
Laboratory sample：Dry towel in wet tissue and table 2 in table 1
Experimental method：SD rats are taken, female, regular grade, weight 220-240g is randomly divided into 16 groups, every group 4.Reference
3.8 in disinfection technology standard (third edition) 1999.11, dry towel, wet tissue are placed in animal intravaginal, contacted with vagina mucosa
2h puts to death animal after 12h, takes out vagina local organization, observes and whether there is congested, oedema phenomenon, reference disinfection technology standard (the
Three editions) the standards of grading scoring of skin wound repair intensity and skin irritatin strength grading in 1999.11, it carries out to vagina mucosa
The evaluation of stimulus intensity.
Experimental result：It is shown in Table 9.
9 vaginal irritation experimental result of table：
Wet tissue of the present invention, dry towel are 0 to rat vagina mucosal irritation reaction top mean value, belong to nonirritant,
Shelf-life is 36 months or more.
Experimental example four is gone to the lavatory towel comprehensive quality test experiments
1st, by carrying out test discovery to the towel of going to the lavatory described in embodiment 6~8, involved in above-described embodiment to towel of going to the lavatory
Dry towel can reach index as shown in table 10, and properties are superior to regulations of the GB/T 20808-2011 to super soft paper.
It goes to the lavatory described in 10 embodiment 6-8 of table the product index of the dry towel of towel
2nd, to embodiment 6 go to the lavatory towel and common commercially available towel products compare, three control groups, control group are set
1 nose noble's face tissue for Japanese king's paper industry production, control group 2 is a tissue of Ni Piao companies production, and control group 3 is
Heng An groups heart chief minister's seal tea family of languages row paper handkerchief, as a result as shown in table 11.
Table 11 is gone to the lavatory towel product actual measurement physical index and correction data
As can be seen from Table 11, the present invention goes to the lavatory, and towel moisture is suitable, and pliability is good, and with good dry drawing
Power and wet tensile strength, entire product sense of touch is soft and moist, and pro-skin sense is strong.
Experimental example five is gone to the lavatory towel material test experiments
The present invention further compared going to the lavatory the material of towel and conventional paper handkerchief, and specific targets are as follows：
1st, body-sensing
Body-sensing refers to comfort during consumer's physical examination product, and the comfort of product is better, and body-sensing is better.Material
Body-sensing comfort is realized by improving 3 indexs of moisture feeling of the flexibility of paper, surface sophistication and paper, so reach with
Nowadays the domestic paper that women generally uses is compared, and has apparent sense of touch otherness.
(1) flexibility
The pliability of domestic paper includes bulk softness and Surface softness.Bulk softness refers to the hands squeeze as people
The softness of paper can be experienced during platen towel；Surface softness refers to finger tip slight amount, and touches paper back and forth and felt
By the softness of paper.According to GB/T 20808-2011 to the regulation of super soft paper, single-part stationery pliability is necessary≤40mN.
(2) surface sophistication
Currently without specific detection means, mainly by user's finger tip slight amount, and paper is touched back and forth and is felt
Judged by the softness of paper, belong to an importance in body-sensing.
(3) moisture feeling
Moisture feeling belongs to the new concept in domestic paper, is put forward for the first time for the application.According to GB/T 20808-2011 to super soft paper
Regulation, delivery moisture be≤9%.
2nd, water imbibition
Mainly weighed by lateral suction range, according to GB/T 20808-2011 to the regulation of super soft paper, single-part stationery
Lateral suction range is more than 20mm/100s.
3rd, breaking up property
For tissue Related product, breaking up property is mainly influenced by the additive amount of wet strength agent.Good paper product can reach
It is abandoned after to use in closestool, does not block closestool and sewer, it is degradable, it is free from environmental pollution.
4th, toughness
Lateral tensile index and longitudinal wet tensile index are better than regulations of the GB/T 20808-2011 to super soft paper, to reach
To will not be broken easily during body paper normal use use, deform.
It is found by comparison, its pliability of currently marketed paper handkerchief is of the present invention small generally between 38-40mN
Its pliability of towel is solved as 30 ± 2mN, belongs to the high-class product in super soft paper；The moisture of paper handkerchief is commonly 7% or so on Vehicles Collected from Market,
The present invention goes to the lavatory, and towel water conservation moisture pick-up properties is good, and paper handkerchief moisture is remained between 15-18%, and exquisiteness is good, and sense of touch is soft
Profit, pro-skin sense are strong；In addition, the present invention goes to the lavatory, the water imbibition of towel also meets national standard, and with good easily disperse, uses
After abandon in closestool, do not block closestool and sewer, it is degradable, it is free from environmental pollution.
In addition to this, table 12 has also listed other differences of go to the lavatory towel and conventional paper handkerchief of the invention.
Table 12 is gone to the lavatory the difference of towel and conventional paper handkerchief
Experimental example six is gone to the lavatory towel market questionnaire investigation
The present invention has carried out questionnaire investigation to towel of going to the lavatory simultaneously, as a result as shown in table 13：The women for having 70.29% thinks very
Like going to the lavatory the texture of towel, 26.43% women waits and see.Generally speaking, the public to the degree of recognition of product close to 80%,
There are extraordinary market prospects.
13 public of table is to the degree of recognition for towel product of going to the lavatory at this stage
The basic principles, main features and the advantages of the invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, this is to this
It is for field technology personnel it will be apparent that these changes and improvements all fall within the protetion scope of the claimed invention.This hair
Bright claimed range is defined by the appending claims and its equivalent thereof.
Claims (15)
1. a kind of have antibacterial, disinfection liquid, it is characterised in that：The liquid include following parts by weight activity into
Point：8-12 parts of Cortex Magnoliae Officinalis alcohol extract, 12-18 parts of Fructus cnidii, 10-15 parts of climbing groundsel alcohol extract, 6-10 parts of usnic acid.
2. liquid as described in claim 1, it is characterised in that：The liquid includes the active constituent of following parts by weight：Cortex Magnoliae Officinalis
10 parts of alcohol extract, 15 parts of Fructus cnidii, 12 parts of climbing groundsel alcohol extract, 8 parts of usnic acid.
3. liquid as claimed in claim 1 or 2, it is characterised in that：The extracting method of the Cortex Magnoliae Officinalis alcohol extract is as follows：By Cortex Magnoliae Officinalis
Fruit grinding and sieving is extracted 2-4 times, extraction time with the 50-70% ethyl alcohol for being equivalent to 8-12 times of its quality at 55-65 DEG C
It is every time 1-3h, merges extracting solution respectively and be condensed into medicinal extract.
4. liquid as claimed in claim 3, it is characterised in that：The extracting method of the Cortex Magnoliae Officinalis alcohol extract is as follows：By Cortex Magnoliae Officinalis fruit
30 mesh sieve is smashed it through in fact, is extracted 3 times at 60 DEG C with 60% ethyl alcohol for being equivalent to 10 times of its quality, extraction time is respectively
2h, 1.5h, 1h, respectively merge extracting solution and be condensed into relative density be 1.1-1.3 medicinal extract to get.
5. liquid as claimed in claim 1 or 2, it is characterised in that：The extracting method of the climbing groundsel alcohol extract is as follows：By thousand
In light be put in 55-65 DEG C of insulating box dry 0.5-2h, grinding and sieving；With the 50-70% second for being equivalent to 10-14 times of its quality
Alcohol extracts 2-4 times at 55-65 DEG C, and extraction time is every time 1-3h, merges extracting solution respectively and is condensed into medicinal extract.
6. liquid as claimed in claim 5, it is characterised in that：The extracting method of the climbing groundsel alcohol extract is as follows：By a thousand li
Light is put in 60 DEG C of insulating boxs dry 1h, smashes it through 30 mesh sieve；It is carried at 60 DEG C with 12 times of 60% ethyl alcohol of its quality is equivalent to
It taking 3 times, extraction time is respectively 2h, 1.5h, 1h, merges extracting solution respectively and is condensed into the medicinal extract that relative density is 1.1-1.3,
To obtain the final product.
7. liquid as claimed in claim 1 or 2, it is characterised in that：The extracting method of the Fructus cnidii is as follows：
Frutus cnidii is put into baking oven, is dried under the drying temperature no more than 60 DEG C；Through grinding and sieving after drying；By powder
Fine powder after broken is imported in extractor, sets extracting pressure 20-30MPa, 40-45 DEG C of temperature, flow control in 25~45L/h,
Primary oil is received per half an hour, until no volatile oil extract to get.
8. liquid as claimed in claim 7, it is characterised in that：The extracting method of the Fructus cnidii is as follows：
Fine powder after crushing is imported in extractor, extracting pressure 25MPa is set, and 42 DEG C of temperature, flow control is in 30~40L/
H receives primary oil per half an hour, until no volatile oil extract to get.
9. the liquid as described in claim 1,2,4,6, any one of 8, it is characterised in that：The liquid with ethanol water,
Water, glycerine or propylene glycol are as solvent.
10. liquid as claimed in claim 9, it is characterised in that：The dosage of the solvent is 200-900 parts by weight.
11. the liquid as described in claim 1,2,4,6,8, any one of 10, it is characterised in that：Perfume (or spice) is further included in the liquid
Feed additives, the spice additive include pure natural spice or artificial flavors.
12. liquid as claimed in claim 11, it is characterised in that：The pure natural spice is selected from elscholtiza, borneol, oriental wormwood, thin
One or more of lotus hydrosol and yellow wormwood artemisia；The artificial flavors include plants essential oil and chemical synthesis essence；The plant essence
Oil is selected from Chinese torreya essential oil, mother chrysanthemum flower essential oil, daphne odera essential oil, pinecone essential oil, mugwort oil, thyme essential oil, eucalyptus quintessence oil, tea
Set one or more of essential oil and camphor tree essential oil.
13. application of any one of the claim 1-12 liquids in hygienic articles are prepared.
14. application according to claim 13, it is characterised in that：The hygienic articles are wet tissue or dry towel.
15. application according to claim 13, it is characterised in that：The hygienic articles are go to the lavatory towel, sanitary napkin or disinfection
Paper.
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| CN109893010A (en) * | 2017-12-12 | 2019-06-18 | 株洲千金药业股份有限公司 | A kind of tender sensitivity skin paper of children and its method of the preparation of prescriptions worth thousand gold dregs of a decoction resource regeneration |
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