CN107899059A - A kind of antiphlogistic antibacterial type tapon and preparation method thereof - Google Patents
A kind of antiphlogistic antibacterial type tapon and preparation method thereof Download PDFInfo
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- CN107899059A CN107899059A CN201711037387.8A CN201711037387A CN107899059A CN 107899059 A CN107899059 A CN 107899059A CN 201711037387 A CN201711037387 A CN 201711037387A CN 107899059 A CN107899059 A CN 107899059A
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- Prior art keywords
- lactic acid
- acid bacteria
- lamella
- metabolites
- antiphlogistic antibacterial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2002—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the use
- A61F13/202—Catamenial tampons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2071—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the material or the structure of the outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2074—Tampons, e.g. catamenial tampons; Accessories therefor impregnated with hydrophobic, hydrophilic, skin enhancers, medicinal etc. substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2082—Apparatus or processes of manufacturing
- A61F13/2085—Catamenial tampons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
The invention discloses a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, the tampon body includes sliver and Lactic Acid Bacteria Metabolites lamella；The Lactic Acid Bacteria Metabolites lamella is arranged at the inside or surface of the sliver.Wherein, the Lactic Acid Bacteria Metabolites lamella is attached with the porous cotton lamella of Lactic Acid Bacteria Metabolites or including Lactic Acid Bacteria Metabolites preparation tabletting for fixation.The invention also discloses the preparation method of this antiphlogistic antibacterial type tapon.The present invention has the characteristics that to adjust acid vagina environment, eliminate colpitis and suppress other bacteria breeds by introducing Lactic Acid Bacteria Metabolites in tapon.
Description
Technical field
The present invention relates to hygiene article sector, more particularly to a kind of antiphlogistic antibacterial type tapon and preparation method thereof.
Background technology
Tapon is a kind of catamenial devices, is contacted by woman's vaginal cavity and absorbs menstruation stream to prevent menstruation from flowing out
Introitus.Built-in tapon because use when do not influence to wear clothes and move, absorb fully will not side leakage, it is more and more
People accreditation and use.
But since tapon is contacted with vaginal epithelial cell the resistance of body may closely declined, between replacement
Every overlong time endometrium can be caused dry and cracked, intravaginal staphylococcus aureus can enter blood circulation system, produce poisoning
Shock-syndrome.Female menstrual period cannot be sterilized effectively, remove toxic shock syndromes, and women is also easy to pruritus of vagina, palace occur
Neck is scorching, the irregular menstruation caused by the pelvic infecton blood stasis deficiency of blood, dysmenorrhoea, through gynecological diseases such as cold and palace colds；Women was obtaining gynaecological disease
Hospital is needed after disease by having an injection, the mode such as take medicine is treated, and easily cross-infection repeatedly.
Therefore tapon needs have the standard and effect of higher in antibacterial sterilize；Simultaneously as tapon is built in
Vagina and spread all over intensive miniature wound in menstrual period endometrium, this also provides dispenser for the prevention and treatment of gynecological disease
Place.
And the metabolin of lactic acid bacteria, can also be by producing hydrogen peroxide or bacterium as lactic acid can maintain vagina pH acid
Usually suppress the growth of pathogenic microorganism.
In order to protect female menstrual period healthy, carry out some researchs on the antimicrobial technology of tapon, and mesh
The amenities of the preceding existing antibacterial bacteriostatic of in the market is mostly medicine antibacterial, and this antimicrobial technology has safety to women's health
Hidden danger, its using when have using avoiding and have residual hazard and side effect, can also cause if long-time service women produce drug resistance from
And its effect is reduced.Nano-antibacterial technology is one kind in physical antibacterial technology, and the size of nanoscale can be utilized to imitate
Higher level strong osmotic and physical antibacterial performance should be brought, but cost is higher.Therefore, urgently exploitation is a kind of at present treats
Imitate, toxic side effect is used with antiphlogistic antibacterial tapon of low cost for numerous women smallly.
The content of the invention
In order to solve the problems, such as that antiphlogistic antibacterial type tapon is of high cost in the prior art, effect is poor, the embodiment of the present invention
Provide a kind of antiphlogistic antibacterial type tapon and preparation method thereof.The technical solution is as follows：
On the one hand, an embodiment of the present invention provides a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, institute
Stating tampon body includes sliver and Lactic Acid Bacteria Metabolites lamella；The Lactic Acid Bacteria Metabolites lamella is arranged at the inside of the sliver
Or surface.
Specifically, the Lactic Acid Bacteria Metabolites lamella is embedded is arranged at the center of the sliver or along the sliver
Central axis around set.
Alternatively, the Lactic Acid Bacteria Metabolites lamella cladding is arranged at the outer surface of the sliver.
Further, the Lactic Acid Bacteria Metabolites lamella is the fixed porous cotton lamella for being attached with Lactic Acid Bacteria Metabolites
Or including Lactic Acid Bacteria Metabolites preparation tabletting.
Preferably, the Lactic Acid Bacteria Metabolites lamella further includes freeze drying protectant.
Specifically, the Lactic Acid Bacteria Metabolites include lactic acid or the composition of lactic acid and acetic acid.
Alternatively, the Lactic Acid Bacteria Metabolites further include the composition of formic acid, propionic acid or formic acid and propionic acid.
Wherein, the freeze drying protectant is in trehalose, sucrose, sodium glutamate, sorbierite, mannitol or glucan
The composition of any one or more.
On the other hand, the embodiment of the invention also discloses a kind of preparation method of antiphlogistic antibacterial type tapon, the side
Method includes：
S1：Absorbency fiber is selected, it is fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10- outside fibre strip layer of cotton thread tail end
20cm；
S4：Fibre strip layer is curled into strip cylindrical absorbent body；
S5：Lactic Acid Bacteria Metabolites lamella is attached and is arranged at fibre strip layer surface, or embedded is arranged at fibre strip
Inside the absorber that layer curls into；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, is got product.
Wherein, the mode that Lactic Acid Bacteria Metabolites lamella is arranged to the fibre strip layer further includes and is metabolized lactic acid bacteria
The attaching of thing lamella is arranged at fibre strip layer surface and composite fibre layer is made.
It should be noted that the term " comprising " used in the present invention is pardon or open, however not excluded that extra
, the element not being quoted or method and step.
Unless otherwise indicated, for the meaning and sheet of all terms (including technical and scientific term) for disclosing the present invention
Field that the present invention belongs to those of ordinary skill institute is normally understood identical, and by further instructing, subsequent definition is used for more preferable
Understanding the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, lactobacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art
(such as species, subspecies, strain).
The beneficial effect that technical solution provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment acid vagina environment by introducing Lactic Acid Bacteria Metabolites in tapon,
Have the characteristics that to eliminate colpitis, suppress other bacteria breeds；
2nd, the lactic acid bacteria main metabolites lactic acid involved in the embodiment of the present invention has antibacterial action, can pass through drop
Low ph value suppresses saccharomycete, fungi, bacterium and some other harmful microbe and grows to strengthen the activity of other acid such as acetic acid
Raw and propagation；And having good biocompatibility with human body, lactic acid is introduced tapon plays non-stimulated antiphlogistic antibacterial
Characteristic；
3rd, the lactic acid bacteria metabolite involved in the embodiment of the present invention is because with good heat endurance and preferably anti-
Hydrogen oxide enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the cotton wool prepared
Bar has effects that anti-inflammatory, antibacterial；
4th, the embodiment of the present invention adds cryoprotector in Lactic Acid Bacteria Metabolites, and is subsequently freeze-dried so that
Lactic acid can keep activity, be conducive to store for a long time；
5th, the Lactic Acid Bacteria Metabolites antimicrobial technology that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, microbial antibacterial etc. have no drug resistance this security risk, the drawbacks of also changing vagina acid-base degree without chemicals, this sterilizing
Mode is safe, nonirritant；
6th, the Lactic Acid Bacteria Metabolites lamella disclosed by the embodiments of the present invention that introduced in the tampon body of tapon prepares anti-inflammatory
The processing step of antimicrobial form tapon is simple, simple operation, of low cost.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, below by the technology in the embodiment of the present invention
Scheme is clearly and completely described, it is clear that and described embodiment is only part of the embodiment of the present invention, rather than entirely
The embodiment in portion.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
All other embodiments obtained, belong to the scope of protection of the invention.
Embodiment 1
An embodiment of the present invention provides a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and Lactic Acid Bacteria Metabolites lamella；Lactic Acid Bacteria Metabolites lamella is arranged at the surface of sliver.The embodiment of the present invention is by defending
Lactic Acid Bacteria Metabolites are introduced in raw sliver, there is adjustment acid vagina environment, is had and is eliminated colpitis, suppresses other bacteriums
The characteristics of growth.
Specifically, Lactic Acid Bacteria Metabolites lamella cladding is arranged at the outer surface of sliver.
Further, Lactic Acid Bacteria Metabolites lamella is the fixed porous cotton lamella for being attached with Lactic Acid Bacteria Metabolites.
Wherein porous cotton lamella suppresses the strip lamella to be formed for natural fiber.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in tampon body with Lactic Acid Bacteria Metabolites lamella.
Or motherwort liquid is impregnated in the porous cotton lamella of above-mentioned Lactic Acid Bacteria Metabolites lamella.
Further, tampon body further includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer further includes motherwort liquid.The active ingredient dosage of motherwort liquid is
2.0g。
In specific implementation, antibacterial layer can be nano antibacterial layer；The present invention can use lactic acid antibacterial and nano-antibacterial
The means that technology is combined, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to breast
Acid for adjusting pH environment so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can be done with the stretching of skin when people moves necessarily may be used
Inverse deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, and basic foreign is filled in not
Suitable sense.
Moreover, pro-skin top layer can be fat-soluble pro-skin top layer or water-soluble pro-skin top layer.Used in the embodiment of the present invention
Water-soluble pro-skin top layer can enhance medical dispenser function as the solvent and carrier of water soluble drug.In the present invention,
Water-soluble pro-skin top layer includes motherwort liquid, can more fully play motherwort it is this have inducing diuresis to remove edema, shrink uterus
Effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus.
Preferably, Lactic Acid Bacteria Metabolites lamella further includes freeze drying protectant.The freeze drying protectant that the embodiment of the present invention uses
For the composition of sodium glutamate, mannitol and glucan.Freeze drying protectant causes lactic acid being remained able to after frozen dried
Activity is kept, is conducive to store for a long time.Specifically, the addition concentration of sodium glutamate, mannitol and glucan be respectively 7.5%,
7.5% and 2.5% w/v (W/V).
Freeze-drying is considered as being most suitable for one of active component dehydration process, its purpose is intended to acquisition solid and stable
Final preparation, be that the suitable cryoprotector of selection is the survival rate for increasing lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, Lactic Acid Bacteria Metabolites include the composition of lactic acid and acetic acid.
In a particular embodiment, lactic acid bacteria metabolite include lactic acid bacteria to the carbon sources such as glucose carry out homofermentation and
Heterofermentation, can produce substantial amounts of lactic acid, acetic acid, further include other acidic end products such as a small amount of formic acid, propionic acid.
Wherein, for lactic acid by reducing pH value to strengthen other sour activity, acetic acid has stronger bacteriostatic activity and wider
Scope of restraining fungi, saccharomycete, fungi can be suppressed, bacterium and some other harmful microbe are grown and propagation.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, specific experiment includes the following steps：
S1, with rubbing method be seeded in nutrient agar tablet by staphylococcus aureus, escherichia coli respectively,
Candida albicans is inoculated with Sabouraud agar medium tablet, Bacillus acidi lactici inoculation MSR agar medium tablets.With 5mm apertures
After card punch punches on the above medium, 20 μ l of sample are added with liquid-transfering gun；
S2, by the culture of staphylococcus aureus, escherichia coli, Candida albicans put in common incubator 37 DEG C of trainings
Support 24 it is small when after observation as a result, the culture of Bacillus acidi lactici put in common incubator 30 DEG C of cultures 48 it is small when after observe；With inhibition zone
Diameter be fungistatic effect characterization parameter, concrete outcome is as shown in table 1.
Inhibition zone data result in 1 lactic acid bacteria metabolite bacteriostatic test of table
| Strain | Staphylococcus aureus | Escherichia coli | Candida albicans | Bacillus acidi lactici |
| Antibacterial circle diameter/mm | 6.7 | 9.2 | 9 | 0 |
1 as shown by data of table, lactic acid bacteria metabolite is for staphylococcus aureus, escherichia coli and Candida albicans
With obvious inhibitory action, inhibitory action is had no for Bacillus acidi lactici.So lactic acid metabolism product is added to tampon body
In, by the use of tampon body as dispenser carrier, not only there is obvious inhibiting effect to harmful bacteria, but also do not influence to maintain acid for vagina
The growth of the flora of the lactic acid bacteria of property environmental benefits.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferable anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, makes a definite diagnosis different degrees of gynaecological imflammation through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, 100 people of control group, 100 people for the treatment of group.
2nd, treatment means
The tapon that control group is added using no lactic acid bacteria metabolite, is used continuously 3 menstrual periods；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, even
It is continuous to use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon for
Improve vaginal environment, the effect of inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether companion
Have frequent micturition, odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, whether posterior fornix of vagina has volume
Leukorrhea and its character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination at the same time and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 2：
The antiphlogistic antibacterial type tapon clinical efficacy that 2 embodiment 1 of table is related to
As shown by data in table 2, used the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type
Tapon, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 35% can be cured, 59%
The inflammation of women can be controlled effectively, and the high efficiency of overall therapeutic is up to 94%.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and sheet of all terms (including technical and scientific term) for disclosing the present invention
Field that the present invention belongs to those of ordinary skill institute is normally understood identical, and by further instructing, subsequent definition is used for more preferable
Understanding the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, lactobacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art
(such as species, subspecies, strain).
The beneficial effect that technical solution provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment acid vagina environment by introducing Lactic Acid Bacteria Metabolites in tapon,
Have the characteristics that to eliminate colpitis, suppress other bacteria breeds；
2nd, the lactic acid bacteria main metabolites lactic acid involved in the embodiment of the present invention has antibacterial action, can pass through drop
Low ph value suppresses saccharomycete, fungi, bacterium and some other harmful microbe and grows to strengthen the activity of other acid such as acetic acid
Raw and propagation；And having good biocompatibility with human body, lactic acid is introduced tapon plays non-stimulated antiphlogistic antibacterial
Characteristic；
3rd, the lactic acid bacteria metabolite involved in the embodiment of the present invention is because with good heat endurance and preferably anti-
Hydrogen oxide enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the cotton wool prepared
Bar has effects that anti-inflammatory, antibacterial；
4th, the embodiment of the present invention adds cryoprotector in Lactic Acid Bacteria Metabolites, and is subsequently freeze-dried so that
Lactic acid can keep activity, be conducive to store for a long time；
5th, the Lactic Acid Bacteria Metabolites antimicrobial technology that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, microbial antibacterial etc. have no drug resistance this security risk, the drawbacks of also changing vagina acid-base degree without chemicals, this sterilizing
Mode is safe, nonirritant.
Embodiment 2
An embodiment of the present invention provides a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and Lactic Acid Bacteria Metabolites lamella；Lactic Acid Bacteria Metabolites lamella is arranged at the inside of sliver, and specifically, above-mentioned lactic acid bacteria
Metabolin lamella is embedded to be arranged at the center of sliver.
Further, Lactic Acid Bacteria Metabolites lamella is the preparation tabletting for including Lactic Acid Bacteria Metabolites.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in above-mentioned Lactic Acid Bacteria Metabolites preparation tabletting with Lactic Acid Bacteria Metabolites lamella.
Further, tampon body further includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer further includes motherwort liquid.The dosage of active ingredient is in motherwort liquid
2.0g。
Wherein, antibacterial layer is nano antibacterial layer；The embodiment of the present invention is combined using lactic acid antibacterial and nano-antibacterial technology
Means, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to newborn acid for adjusting pH ring
Border so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can be done with the stretching of skin when people moves necessarily may be used
Inverse deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, and basic foreign is filled in not
Suitable sense.
Preferably, the Lactic Acid Bacteria Metabolites lamella further includes freeze drying protectant.
Specifically, the freeze drying protectant used in the embodiment of the present invention for sucrose, sorbierite and mannitol composition.
Specifically, the addition concentration of sucrose, sorbierite and mannitol is respectively 10%, 4% and 7.5% w/v (W/V).Freeze
Dry protective agent causes lactic acid being maintained to activity after frozen dried, is conducive to store for a long time.
Freeze-drying is considered as being most suitable for one of active component dehydration process, its purpose is intended to acquisition solid and stable
Final preparation, be that the suitable cryoprotector of selection is the survival rate for increasing lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, the Lactic Acid Bacteria Metabolites include the composition of lactic acid and acetic acid, further include a small amount of formic acid and propionic acid
Composition.
In a particular embodiment, lactic acid bacteria metabolite include lactic acid bacteria to the carbon sources such as glucose carry out homofermentation and
Heterofermentation, can produce other acidic end products such as substantial amounts of lactic acid, acetic acid and a small amount of formic acid, propionic acid.
Wherein, for lactic acid by reducing pH value to strengthen other sour activity, acetic acid has stronger bacteriostatic activity and wider
Scope of restraining fungi, saccharomycete, fungi can be suppressed, bacterium and some other harmful microbe are grown and propagation；Propionic acid is to ferment
Female bacterium and fungi have very strong bacteriostasis.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, test data shows, lactic acid bacteria metabolite for
Staphylococcus aureus, escherichia coli and Candida albicans have obvious inhibitory action, for Bacillus acidi lactici and unrestraint
Effect.So lactic acid metabolism product is added in tampon body, by the use of tampon body as dispenser carrier, both to harmful bacteria
There is obvious inhibiting effect, and do not influence to maintain the growth of the flora of the favourable lactic acid bacteria of sour environment for vagina.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferable anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, makes a definite diagnosis different degrees of gynaecological imflammation through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, 100 people of control group, 100 people for the treatment of group.
2nd, treatment means
The tapon that control group is added using no lactic acid bacteria metabolite, is used continuously 3 menstrual periods；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, even
It is continuous to use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon for
Improve vaginal environment, the effect of inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether companion
Have frequent micturition, odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, whether posterior fornix of vagina has volume
Leukorrhea and its character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination at the same time and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 3：
The antiphlogistic antibacterial type tapon clinical efficacy that 3 embodiment 2 of table is related to
As shown by data in table 3, used the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type
Tapon, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 28% can be cured, 60%
The inflammation of women can be controlled effectively, and the high efficiency of overall therapeutic is up to 88%.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and sheet of all terms (including technical and scientific term) for disclosing the present invention
Field that the present invention belongs to those of ordinary skill institute is normally understood identical, and by further instructing, subsequent definition is used for more preferable
Understanding the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, lactobacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art
(such as species, subspecies, strain).
The beneficial effect that technical solution provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment acid vagina environment by introducing Lactic Acid Bacteria Metabolites in tapon,
Have the characteristics that to eliminate colpitis, suppress other bacteria breeds；
2nd, the lactic acid bacteria main metabolites lactic acid involved in the embodiment of the present invention has antibacterial action, can pass through drop
Low ph value suppresses saccharomycete, fungi, bacterium and some other harmful microbe and grows to strengthen the activity of other acid such as acetic acid
Raw and propagation；And having good biocompatibility with human body, lactic acid is introduced tapon plays non-stimulated antiphlogistic antibacterial
Characteristic；
3rd, the lactic acid bacteria metabolite involved in the embodiment of the present invention is because with good heat endurance and preferably anti-
Hydrogen oxide enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the cotton wool prepared
Bar has effects that anti-inflammatory, antibacterial；
4th, the embodiment of the present invention adds cryoprotector in Lactic Acid Bacteria Metabolites, and is subsequently freeze-dried so that
Lactic acid can keep activity, be conducive to store for a long time；
5th, the Lactic Acid Bacteria Metabolites antimicrobial technology that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, microbial antibacterial etc. have no drug resistance this security risk, the drawbacks of also changing vagina acid-base degree without chemicals, this sterilizing
Mode is safe, nonirritant.
Embodiment 3
An embodiment of the present invention provides a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, tampon body to include
Sliver and Lactic Acid Bacteria Metabolites lamella；Lactic Acid Bacteria Metabolites lamella is arranged at the inside of sliver.
Specifically, the embedded inside for being arranged at sliver of Lactic Acid Bacteria Metabolites lamella and it is surround along the central axis of sliver
Set.
Further, Lactic Acid Bacteria Metabolites lamella is the fixed porous cotton lamella for being attached with Lactic Acid Bacteria Metabolites.
In a particular embodiment, it is possibility to have motherwort or the combination of other Chinese medicines are in the form of powdered, Formulation
It is added to jointly in tampon body with Lactic Acid Bacteria Metabolites lamella.Or the porous cotton piece in above-mentioned Lactic Acid Bacteria Metabolites lamella
Motherwort liquid is impregnated in layer.Motherwort liquid, can more fully play motherwort it is this have inducing diuresis to remove edema, shrink son
Palace effect Chinese medicine treatment irregular menstruation, dysmenorrhoea, through gynecological diseases such as cold and palace colds and health care uterus.
Further, tampon body further includes composite web top layer；Composite web top layer is coated on the outer surface of sliver.
Specifically, composite web top layer is disposed with pro-skin top layer and antibacterial layer from outside to inside.
Wherein, pro-skin top layer is fat-soluble pro-skin top layer or water-soluble pro-skin top layer.
Further, water-soluble pro-skin top layer further includes motherwort liquid.Active ingredient dosage is in motherwort liquid
0.5g。
Wherein, antibacterial layer is nano antibacterial layer；The embodiment of the present invention is combined using lactic acid antibacterial and nano-antibacterial technology
Means, higher level strong osmotic effect can be brought using the dimensional effect of nanoscale, with reference to newborn acid for adjusting pH ring
Border so that this sterilization method is safer, long-acting.
The embodiment of the present invention makes using the suppleness and biocompatibility on the pro-skin top layer coated in the outer surface of sliver
Tapon is more soft and adhere well to skin, tapon can be done with the stretching of skin when people moves necessarily may be used
Inverse deformation, it is ensured that the close of tapon is filled in while the comfort level of user significantly improves, and basic foreign is filled in not
Suitable sense.
Moreover, pro-skin top layer can be fat-soluble pro-skin top layer or water-soluble pro-skin top layer.Used in the embodiment of the present invention
Fat-soluble pro-skin top layer, can cause the outer surface of tapon more lubricates to be easy to fill in vivo, be conducive to tapon more
Give full play to medical dispenser function.
A variety of combinations of lactic acid and tapon can cause the bioactivity point of lactic acid in the embodiment of the present invention
Son diffusive migration uniform when in use can make full use of menstrual period endometrium to spread all over close to positions such as vagina top layer, uterus inner walls
The miniature wound dispenser of collection, has preferable therapeutic effect；In this specific implementation, lactic acid can be with motherwort or other Chinese medicines such as
Angelica sinensis, radix glycyrrhizae, rhizoma zingiberis, perilla leaf, folium artemisiae argyi and Ge Gong etc. carry out certain proportion mixing, play acidic pH environment antibacterial and Chinese medicine
Pharmacology cooperates with antiinflammation, and more preferable therapeutic effect is played for gynecological disease.
Preferably, Lactic Acid Bacteria Metabolites lamella further includes freeze drying protectant.Frozen-dried protective is used in embodiments of the present invention
Agent is mannitol and the composition of glucan.Specifically, the addition concentration of mannitol and glucan is respectively 7.5% and 2.5%
W/v (W/V).
Freeze-drying is considered as being most suitable for one of active component dehydration process, its purpose is intended to acquisition solid and stable
Final preparation, be that the suitable cryoprotector of selection is the survival rate for increasing lactic acid bacteria during lyophilized and subsequent storage
Key factor.
Specifically, Lactic Acid Bacteria Metabolites include lactic acid.
In a particular embodiment, lactic acid bacteria metabolite include lactic acid bacteria to the carbon sources such as glucose carry out homofermentation and
Heterofermentation, can produce other acidic end products such as substantial amounts of lactic acid, acetic acid and a small amount of formic acid, propionic acid.The present invention is implemented
Example is separated for the lactic acid in lactic acid bacteria metabolite this metabolite, purifies to obtain.
Lactic acid suppresses saccharomycete, fungi, bacterium and the growth of some other harmful microbe and increasing by reducing pH value
Grow；And lactic acid has good heat endurance and preferable anti-oxidant hydrogen enzyme and antiprotease activity, and as pH value drops
It is low, the enhancing of its bacteriostasis.
In order to verify that the fungistatic effect of lactic acid has carried out bacteriostatic test, specific experiment includes the following steps (same to embodiment
1)：
S1, with rubbing method be seeded in nutrient agar tablet by staphylococcus aureus, escherichia coli respectively,
Candida albicans is inoculated with Sabouraud agar medium tablet, Bacillus acidi lactici inoculation MSR agar medium tablets.With 5mm apertures
After card punch punches on the above medium, 20 μ l of sample are added with liquid-transfering gun；
S2, by the culture of staphylococcus aureus, escherichia coli, Candida albicans put in common incubator 37 DEG C of trainings
Support 24 it is small when after observation as a result, the culture of Bacillus acidi lactici put in common incubator 30 DEG C of cultures 48 it is small when after observe；With inhibition zone
Diameter be fungistatic effect characterization parameter, concrete outcome is as shown in table 1.
The as shown by data of bacteriostatic test, lactic acid bacteria metabolite is for staphylococcus aureus, escherichia coli and white
Candida albicans has obvious inhibitory action, and inhibitory action is had no for Bacillus acidi lactici.So lactic acid metabolism product is added to health
In tampon body, by the use of tampon body as dispenser carrier, not only there is obvious inhibiting effect to harmful bacteria, but also do not influence for vagina
Maintain the growth of the flora of the favourable lactic acid bacteria of sour environment.
In addition, there is lactic acid bacteria metabolite good heat endurance and preferable anti-oxidant hydrogen enzyme and antiprotease to live
Property, and as pH value reduces, the enhancing of its bacteriostasis.
In order to further prove the antiphlogistic antibacterial effect of the embodiment of the present invention, clinical test has also been carried out.
1st, clinical observation
Using the present embodiments relate to antiphlogistic antibacterial type tapon be supplied to the women of use demand totally 200
People, makes a definite diagnosis different degrees of gynaecological imflammation through gynecologial examination, its age distribution was at 20~48 years old, average out to 35 years old.At random
It is divided into two groups, 100 people of control group, 100 people for the treatment of group.
2nd, treatment means
The tapon that control group is added using no lactic acid bacteria metabolite, is used continuously 3 menstrual periods；
Treatment group choosing the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon, even
It is continuous to use 3 menstrual periods.
3rd, diagnostic criteria
In order to verify the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type tapon for
Improve vaginal environment, the effect of inhibiting bacteria and diminishing inflammation, employ the amount of vaginal fluid, whether have pruritus vulvue, cusalgia, whether companion
Have frequent micturition, odynuria and intercourse pain, vagina mucosa it is whether congested or it is visible be dispersed in bleeding spot, whether posterior fornix of vagina has volume
Leukorrhea and its character, smell are as clinical judgment symptom；
The gemma of trichomonad or candidiasis judged using vaginal fluid laboratory examination at the same time and mycelia whether there is and
Amount number.
4th, efficacy assessment standard
Cure：After treatment end, clinical symptoms are wholly absent；
Effectively：After treatment end, clinical symptoms partial disappearance, the state of an illness is alleviated substantially；
It is invalid：After treatment end, clinical symptoms are not taken on a new look substantially, disease amelioration unobvious.
Specific treatment results are shown in Table 4：
The antiphlogistic antibacterial type tapon clinical efficacy that 4 embodiment 3 of table is related to
As shown by data in table 2, used the present embodiments relate to have lactic acid metabolism product add antiphlogistic antibacterial type
Tapon, the clinical symptoms of the colpitis of the women for the treatment of group are eased, and have 31% can be cured, 63%
The inflammation of women can be controlled effectively, and the high efficiency of overall therapeutic is up to 94%.
Term " comprising " used in the present invention is pardon or open, however not excluded that extra, be not quoted
Element or method and step；
Unless otherwise indicated, for the meaning and sheet of all terms (including technical and scientific term) for disclosing the present invention
Field that the present invention belongs to those of ordinary skill institute is normally understood identical, and by further instructing, subsequent definition is used for more preferable
Understanding the teachings of the present invention.
Involved " lactic acid bacteria (lactic acid bacterium) " this term, typically refers to be selected from the present invention
Lactococcus (lactoucoccus) species, lactobacillus (Lactobacilus) species, streptococcus
(Streptococcus) species, Pediococcus (Pediococcus) species, Bifidobacterium (Bifidobacterium) thing
The bacterium of kind and Leuconostoc (Leuconostoc) species, and including being classified as above-mentioned any monoid in the art
(such as species, subspecies, strain).
The beneficial effect that technical solution provided in an embodiment of the present invention is brought is：
1st, the embodiment of the present invention has adjustment acid vagina environment by introducing Lactic Acid Bacteria Metabolites in tapon,
Have the characteristics that to eliminate colpitis, suppress other bacteria breeds；
2nd, the lactic acid bacteria main metabolites lactic acid involved in the embodiment of the present invention has antibacterial action, can pass through drop
Low ph value suppresses saccharomycete, fungi, bacterium and some other harmful microbe and grows to strengthen the activity of other acid such as acetic acid
Raw and propagation；And having good biocompatibility with human body, lactic acid is introduced tapon plays non-stimulated antiphlogistic antibacterial
Characteristic；
3rd, the lactic acid bacteria metabolite involved in the embodiment of the present invention is because with good heat endurance and preferably anti-
Hydrogen oxide enzyme and antiprotease activity, and as pH value reduces, its bacteriostasis enhancing, so that the cotton wool prepared
Bar has effects that anti-inflammatory, antibacterial；
4th, the embodiment of the present invention adds cryoprotector in Lactic Acid Bacteria Metabolites, and is subsequently freeze-dried so that
Lactic acid can keep activity, be conducive to store for a long time；
5th, the Lactic Acid Bacteria Metabolites antimicrobial technology that the embodiment of the present invention uses resists relative to the medicine in existing hygienic articles
Bacterium, microbial antibacterial etc. have no drug resistance this security risk, the drawbacks of also changing vagina acid-base degree without chemicals, this sterilizing
Mode is safe, nonirritant.
Embodiment 4
The embodiment of the invention also discloses the preparation method for preparing above-mentioned antiphlogistic antibacterial type tapon, method includes：
S1：Absorbency fiber is selected, it is fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10- outside fibre strip layer of cotton thread tail end
20cm, is preferably 12cm；
S5：Fibre strip layer is curled into strip cylindrical absorbent body；
S6：Lactic Acid Bacteria Metabolites lamella is attached and is arranged at fibre strip layer surface, or embedded is arranged at fibre strip
Inside the absorber that layer curls into；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, is got product.
Wherein, the mode that Lactic Acid Bacteria Metabolites lamella is arranged to the fibre strip layer further includes and is metabolized lactic acid bacteria
The attaching of thing lamella is arranged at fibre strip layer surface and composite fibre layer is made.
Specifically, absorbency fiber is natural fiber or synthetic fibers in step S1；
The specific weight that fixed weight absorbency fiber is weighed in step S2 is 1.5g-4.0g, is preferably 3.5g.
Above-mentioned Lactic Acid Bacteria Metabolites lamella is arranged at sliver outer surface.In specific implementation, Lactic Acid Bacteria Metabolites lamella is also
The inside of sliver can be arranged at, embedded can be arranged at the center of sliver or surround setting along the central axis of sliver.
Further, Lactic Acid Bacteria Metabolites lamella is Lactic Acid Bacteria Metabolites preparation tabletting.In specific implementation, lactic acid bacteria
Metabolin lamella can also be the fixed porous cotton lamella for being attached with Lactic Acid Bacteria Metabolites.Wherein, Lactic Acid Bacteria Metabolites has
Effect content is 0.5-2.0g, is preferably 1.5g.
In specific implementation, lactic acid can be with motherwort or other Chinese medicines such as Angelica sinensis, radix glycyrrhizae, rhizoma zingiberis, perilla leaf, folium artemisiae argyi
Certain proportion mixing is carried out with Ge Gong etc., acidic pH environment antibacterial is played and cooperates with antiinflammation with herbal pharmacology, for gynaecology's disease
Disease plays more preferable therapeutic effect.
In step s 6, Chinese herbal medicine is added to jointly in the form of powdered, Formulation with Lactic Acid Bacteria Metabolites lamella
In tampon body.Or impregnate herbal liquid medicine in the porous cotton lamella of above-mentioned Lactic Acid Bacteria Metabolites lamella.The medium-height grass of dipping
The amount of medicine liquid is 0.5-5.0mL, is preferably 0.5g..
The introducing Lactic Acid Bacteria Metabolites lamella disclosed by the embodiments of the present invention in the tampon body of tapon prepares anti-inflammatory and resists
The processing step of bacterial type tapon is simple, simple operation, of low cost, and obtained tapon product has with adjusting
Acid vagina environment, has the characteristics that to eliminate colpitis, suppresses other bacteria breeds；And there is good biology with human body
Compatibility, introduces tapon by lactic acid and plays non-stimulated antiphlogistic antibacterial characteristic.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of antiphlogistic antibacterial type tapon, including tampon body and cotton thread, it is characterised in that the tampon body include sliver and
Lactic Acid Bacteria Metabolites lamella；The Lactic Acid Bacteria Metabolites lamella is arranged at the inside or surface of the sliver.
2. antiphlogistic antibacterial type tapon according to claim 1, it is characterised in that the Lactic Acid Bacteria Metabolites lamella is embedding
Enter formula to be arranged at the center of the sliver or surround setting along the central axis of the sliver.
3. antiphlogistic antibacterial type tapon according to claim 1, it is characterised in that the Lactic Acid Bacteria Metabolites lamella bag
Cover the outer surface for being placed in the sliver.
4. the antiphlogistic antibacterial type tapon according to claim 1-3 any one, it is characterised in that the lactic acid bacteria generation
Thank to thing lamella and be attached with the porous cotton lamella of Lactic Acid Bacteria Metabolites or including Lactic Acid Bacteria Metabolites preparation tabletting for fixation.
5. antiphlogistic antibacterial type tapon according to claim 4, it is characterised in that the Lactic Acid Bacteria Metabolites lamella is also
Including freeze drying protectant.
6. antiphlogistic antibacterial type tapon according to claim 4, it is characterised in that the Lactic Acid Bacteria Metabolites include breast
Acid or the composition of lactic acid and acetic acid.
7. antiphlogistic antibacterial type tapon according to claim 6, it is characterised in that the Lactic Acid Bacteria Metabolites further include
The composition of formic acid, propionic acid or formic acid and propionic acid.
8. antiphlogistic antibacterial type tapon according to claim 5, it is characterised in that the freeze drying protectant is seaweed
The composition of any one or more in sugar, sucrose, sodium glutamate, sorbierite, mannitol or glucan.
A kind of 9. preparation method of antiphlogistic antibacterial type tapon, it is characterised in that the described method includes：
S1：Absorbency fiber is selected, it is fully dry；
S2：Fixed weight absorbency fiber is weighed, absorbency fiber is pressed into fibre strip layer；
S3：Cotton thread is fixed in fibre strip layer centre, the exposed 10-20cm outside fibre strip layer of cotton thread tail end；
S4：Fibre strip layer is curled into strip cylindrical absorbent body；
S5：Lactic Acid Bacteria Metabolites lamella is attached and is arranged at fibre strip layer surface, or the embedded fibre strip layer that is arranged at is rolled up
It is curved into absorber inside；
S6：It is with non-woven fabrics that absorber tight is exposed outside tampon body into tampon body, cotton thread tail end；
S7：Tampon body is packed, is got product.
10. the preparation method of antiphlogistic antibacterial type tapon according to claim 9, it is characterised in that by lactic acid bacteria generation
Thank thing lamella be arranged at the fibre strip layer mode further include by Lactic Acid Bacteria Metabolites lamella attach be arranged at fibre strip
Composite fibre layer is made in layer surface.
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| CN109394423A (en) * | 2018-12-13 | 2019-03-01 | 湖南千金卫生用品股份有限公司 | A kind of promoting blood circulation for regulating menstruation tapon and preparation method thereof |
| CN109589443A (en) * | 2018-12-13 | 2019-04-09 | 湖南千金卫生用品股份有限公司 | A kind of analgesic tapon and preparation method thereof |
| CN109394423B (en) * | 2018-12-13 | 2021-10-08 | 湖南千金卫生用品股份有限公司 | Blood-activating menstruation-regulating tampon and preparation method thereof |
| CN109589443B (en) * | 2018-12-13 | 2021-11-16 | 湖南千金卫生用品股份有限公司 | Pain-relieving sanitary cotton strip and preparation method thereof |
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