CN108452295A - A kind of compact gel and preparation method antibacterial, that adjust microecological balance - Google Patents
A kind of compact gel and preparation method antibacterial, that adjust microecological balance Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The present invention a kind of compact gel and preparation method antibacterial, that adjust microecological balance, raw material by weight ratio, is made by 2 ~ 5 parts of 1 ~ 3 part of hydroxyethyl cellulose, 4 ~ 6 parts of kuh-seng root extract, 3 ~ 5 parts of Radix Stemonae extract, 1 ~ 3 part of collagen peptide, 3 ~ 5 parts of cnidium monnieri berry extract, 3 ~ 5 parts of phellodendron extract, 2 ~ 4 parts of Chinese prickly ash berry extract, 2 ~ 4 parts of safranine flower extract, 2 ~ 3 parts of Herba Saussureae Involueratae extract, 1 ~ 3 part of hamamelis leaf extract, Bacillus acidi lactici combinations.Vagina harmful pathogenic bacteria can be killed, and vagina profitable strain can be protected, adjust microecology in vaginas balance, improve female reproductive system immunity, at the same also can palace of the Qing Dynasty toxin expelling, repair vaginal injury mucous membrane, improve that vaginal relaxation is dry and astringent, convergence is compacted.
Description
Technical field
The present invention relates to a kind of Gynecological health nursing materials, it is specifically a kind of have it is antibacterial, adjust microecological balance,
Restrain the gynecological gel for the triple function that compacts.
Technical background
It is well known that gynaecological imflammation is married femle's common disease, since many women lack to reproductive system caring
Consciousness, leads to intravaginal acid-base imbalance, and flora is unbalance, and Tiny ecosystem is destroyed, and pathogenic bacteria avail oneself of the opportunity to get in, and then causes various woman
Section's inflammation.
Female reproductive system is the important Tiny ecosystem area of human body, is the Tiny ecosystem formed based on beneficial bacterium under normal circumstances
Balance, most importantly Bacillus acidi lactici in vaginal fluid, it is antimicrobial that it can generate some in the vagina of healthy women
Substance, control vaginal flora balance and acid-base balance.In the factor for maintaining microecology in vaginas balance, estrogen, Bacillus acidi lactici
And vagina acid-base degree plays a crucial role.Under normal physiological conditions, estrogen makes vagina epithelium hyperplasia thicken and is rich in
Glycogen, increases the resistance to pathogen, and glycogen is decomposed into lactic acid under Vaginal lactobacilli effect, maintains vagina normally sour
Property environment（PH value is 3.8 ~ 4.4）.Microecology in vaginas balance is once broken or foreign pathogens intrusion, you can leads to vagina pH
Value increases, and mucosal secretions function is destroyed, pudendal pruritus, leucorrhea increasing often occurs, have the symptoms such as peculiar smell, will attract one
Serial gynaecological imflammation, such as trichomonas vaginitis, colpomycosis, bacterial vaginitis, many illnesss such as cervical erosion,
Also it can make vaginal relaxation, dry and astringent, pain, influence sexual life and reproductive system health.
There are many gynecological gel class product currently used for female reproductive system, and most of killed for the purpose of sterilization
Also many probiotics have been killed while pathogenic bacteria, lead to intravaginal flora imbalance, vagina hypoimmunity, to cause gynaecology
Inflammation recurrent exerbation.
Also there is part gynecological gel by adjusting women microecological balance come prophylaxis of gynaecological disorders, but effect is also all and unreasonably
Think.
Patent discloses a kind of draft bacteriostatic gel, by Cortex Phellodendri 1 .0 ~ 3 .5%, kuh-seng 1 .5 ~ 4 .0%, 0 .5 of Japanese Stephania Root
~ 3 .5%, mint extract 0 .3 ~ 2 .8%, Leonurus extract 0 .4 ~ 3 .0%, Aloe Vera Gel 40 ~ 65%, 0 .3 of kardiseed ~
2 .0%, Radix Angelicae Sinensis 0 .5 ~ 3 .0%, Honegsukle flower P.E 0 .1 ~ 3 .0%, common cnidium fruit P.E 0 .3 ~ 2 .3%, 0 .1 of nano silver
~ 1 .2%, acetic acid chlorhexidine 0 .8 ~ 1 .2%, vitamin E 0 .2 ~ 1 .6%, glycerine 6 ~ 18%, 0 .8 of aluminosilicate polyacrylate
~ 2 .0%, gel-type vehicle carbomer 0 .5 ~ 3 .0%, triethanolamine 1 .0 ~ 5 .5% are made.The product is carried with a variety of Chinese herbal medicines
It takes object to be formulated, nano silver and acetic acid chlorhexidine is added in formula, sterilizing ability is stronger, at the same time to vagina mucosa
There is certain stimulation.And product pH value is normal beyond vagina 6 ~ 7（PH value is 3.8 ~ 4.4）Range destroys acid vagina environment,
Colony balance can be also destroyed, and be easy to cause a series of gynaecological imflammations.
CN 106938029A patents disclose a kind of bacteriostatic gel and preparation method thereof, by 4 ~ 5 parts of kuh-seng, frutus cnidii 2 ~ 3
Part, 1 ~ 2 weight part of Cortex Phellodendri, 1 ~ 2 part of safflower, 0.5 ~ 1 part of aloe, 0.5 ~ 1 part of curcuma zedoary, 0.01 ~ 0.02 part of menthol, carbomer 2 ~ 3
Part, 1 ~ 2 part of triethanolamine.Add purified water to decoct 2 times kuh-seng, frutus cnidii, Cortex Phellodendri, safflower, aloe, curcuma zedoary, it is spare to obtain A liquid；
After carbomer impregnates dissolving with purified water, filtrate is filtered to take, it is spare to obtain B liquid；A liquid is added in B liquid, is uniformly mixed, then
Menthol is added, ethylparaben is made.The product is to improve and prevent gynaecological imflammation using Chinese herbal medicine is reasonably combined, but produce
It is normal to exceed vagina 5~7 for product pH value（PH value is 3.8 ~ 4.4）Range destroys vagina acid-base balance, is easy to cause gynaecology's inflammation
Disease recurrent exerbation.
CN 107243017A disclose antibacterial balance gynecological gel of one kind and preparation method thereof, by cationic polysaccharide
0.1 ~ 2.0%, moisturizer 5.0 ~ 20%, thickener 0.1 ~ 2.0%, balance flora composite extract 5 ~ 25%, acidity regulator 0.1 ~
2.0%, surplus is purified water, and acidity regulator is added, and it is 2.5 ~ 4.5 to adjust pH value, and cationic polysaccharide and thickening is being added
Agent, moisturizer and balance flora composite extract are made.The product adjusts the acyclic acidic that pH value is 2.5 ~ 4.5 to balance flora
For the purpose of border, the immersion of external source pathogenic bacteria cannot be prevented and cause gynecological diseases.
CN 102091189A disclose a kind of gynecological gel, by gallic acid 3 ~ 20,5 ~ 15 Echinacea Purpurea Herb P.E of Chinese podophyllum root
3 ~ 8, Noni extract 4 ~ 11, propolis 3 ~ 9, trollflower 1 ~ 19, rhodiola root 8 ~ 20, kuh-seng 7 ~ 17, realgar 3 ~ 12, the coptis 3 ~ 8,
Safflower 4 ~ 13, vitamin e 2 ~ 6, borneol 2 ~ 8 are made.The product cannot prevent the leaching of external source pathogenic bacteria to balance based on flora
Enter and causes gynecological diseases.
CN101797304A discloses a kind of gel of adjusting microecology in vaginas of women, by 0.5 ~ 2% carbomer, 0.1 ~
1% soybean peptide, 0.001 ~ 0.01% isoflavones, 0.5 ~ 3.5% carrotene, 0.3 ~ 3% tea oil are made.The production
Product cannot prevent the immersion of external source pathogenic bacteria and cause gynecological diseases for the purpose of adjusting microecology in vaginas balance.
CN101524457A discloses a kind of vagina-shrinking expellent bacteriostatic gel, by peony 3, safflower 3, rose 4-6, open country
Chrysanthemum 3, pomegranate flower 6-8, Chinese trumpet creeper 2, fan's butterfly perfume (or spice) 5-7, Flos Papaveris rhoeadis 4-6, lotus 2, peach blossom 2, China rose 3, honeysuckle 3, the purple tip
Spend 1, pot marigold 2, Jasmine 4, Flos Daturae 5-7, cortex magnoliae officinalis spend 3, Chinese gall 5-7, kuh-seng 2, motherwort 1.5, purslane 10-14,
Myrrh 4-6, branch shell 7-9, the seed of garden balsam 4, Chinese yam 1.5.Original liquid is made by different weight extraction, adds benzoic acid in 3 ‰ ratio
Sodium, it is matrix to take sodium carboxymethylcellulose to be made into 6% with purified water, impregnates uniformly, is 1: 2 stirring original liquid plus matrix ratios
After uniformly, become gel.The product is for the purpose of toxin expelling, promotion vagina contraction.
Invention content
Vagina harmful pathogenic bacteria can be killed the object of the present invention is to provide one kind and protects vagina profitable strain, adjusted cloudy
Road microecological balance improves female reproductive system immunity, while also can palace of the Qing Dynasty toxin expelling, reparation vaginal injury mucous membrane, improvement the moon
The road dry and astringent, convergence that relaxes is compacted the gel for women and preparation method thereof of triple function.
The present invention is antibacterial, adjusts the gel process for preparing that compacts of microecological balance：
Raw material is by weight ratio
(1) by 1 ~ 3 part of addition deionized water of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 75 DEG C ~ 85 DEG C；
(2) by kuh-seng（Sophora flavescens）4 ~ 6 parts of root extract, the tuber of stemona（Stemonae Radix）Extract 3 ~ 5
Part, 1 ~ 3 part of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）3 ~ 5 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 3 ~ 5
Part, Chinese prickly ash（Zanthoxylumbungeanum) 2 ~ 4 parts of berry extract, 2 ~ 4 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2 ~ 3 parts of extract, continues to stir, and cool down
To 45 DEG C ~ 55 DEG C；
(3) hamamelis is added（Hamamelis virginiana）1 ~ 3 part of leaf extract, 2 ~ 5 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
In mentioned component, hydroxyethyl cellulose is a kind of very important rheology control agent, there is the purposes such as thickening, suspension,
Stability is good, can prepare the bacteriostatic gel of very wide range of viscosities and different rheological characteristics, and good water solubility, and appearance transparent is beautiful,
There is special fine and smooth smooth feeling, it is fine to close effect with vaginal mucosal tissue lotus root.
Kuh-seng（Sophora flavescens）Root extract has heat-clearing and damp-drying drug, desinsection antipruritic, anti-inflammatory, antitumor, anti-
Bacterium, anti-allergic effects have trichomonad, mold fungi, bacterium, mycoplasma, Chlamydia the killing effect of strength.
The tuber of stemona（Stemonae Radix）Extract has resisting pathogenic microbes effect and insecticidal action, to golden yellow grape
Coccus, staphylococcus albus, shigella dysenteriae, typhoid bacillus, paratyphosum Bacterium, Escherichia coli, proteus, corynebacterium diphtheriae, lung
Scorching bacillus, yersinia pestis, bacillus anthracis, hay bacillus and comma bacillus etc. have different degrees of inhibiting effect.To mosquitos and flies
Larva, pinworm, head louse, clothing lice and bedbug etc. have killing effect.
Collagen peptide permeability is strong, can pass through vagina mucosa and cell combination, and good with the compatibility of surrounding tissue, can
Helper cell is manufactured into collagen, promotes cell tissue normal growth, updates the cell component of outmoded aging, and displacement excludes thin
The toxin of intracellular improves vagina living environment and promotes the metabolism of tissue, enhances blood circulation, can make loose vagina group
It knits consolidation, restore elasticity, slow down aging.
Cnidium monnieri（Cnidium monnieri）The effect of berry extract has eliminating dampness wind-dispelling, and desinsection is antipruritic, warming kidney and enhancing body.Often
For treating under pruritus vulvae band, rubella, eczema, pruitus, arthritis with fixed pain caused by dampness pain in the back, the multiple gynecologicals such as uterus cold infertile and trichomonas vaginitis
Inflammation.
Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract heat-clearing and damp-drying drug, purging intense heat and detonicating, except hectic fever due to yin is empty clearly
Heat.For damp-heat dysentery, leukorrhea with reddish discharge, sore swollen toxin, eczema itch.Its antibiotic effective ingredient is jamaicin, to golden yellow Portugal
Grape coccus, Streptococcus viridans, shigella dysenteriae, hemolytic streptococcus, comma bacillus, bacillus anthracis have stronger inhibition to make
With.
Chinese prickly ash（Zanthoxylum bungeanum）Berry extract warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, bacterio static itching-relieving, desinsection solution
Poison.For treating the symptoms such as women pruritus vulvae and eczema itch.To bacillus anthracis, hemolytic streptococcus, corynebacterium diphtheriae, the double balls of pneumonia
10 kinds of gram-positive bacterias such as bacterium, staphylococcus aureus, lemon yellow and staphylococcus albus, hay bacillus and large intestine bar
The enterals pathogenic bacteria such as bacterium, sonnei dysentery bar flute, proteus, typhoid fever and paratyphosum Bacterium, Pseudomonas aeruginosa, comma bacillus have
Apparent inhibiting effect.
Safflower（Crocussativus ）Extract has promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, dissipates Yu Kaijie, improves anemia body
Void is enriched blood, blood-nourishing effect.For treating women's Amenorrhea, stasis, irregular menstruation, prolonged lochia, hemostasis is had a pain.
Lanatechead saussurea herb with flower（Saussurea involucrata (Kar. et Kir.)Sch.-Bip）Extract has antibacterial stop
Itch, invigorate blood circulation, dispelling cold and removing dampness, warm the womb dissipate the stasis of blood, hemostasia and detumescence, palace of the Qing Dynasty toxin expelling, the foster nest that compacts, moisten yin-nourishing effect.For
Treat menoxenia, closed dysmenorrhea, under uterine bleeding band, the diseases such as lumbago due to the kidney deficiency.
Hamamelis（Hamamelis virginiana）There are leaf extract antipruritic, swelling and pain of releiving of stopping blooding, consolidation to receive
Hold back, antibacterial detumescence, anti-aging, healing of wound the effect of.There is fine curative effect to the skin disease of some inflammation.
Bacillus acidi lactici is one kind of lactic acid bacteria, is the probiotics being present in mankind's body, it is a huge flora, is had
Evil bacterium is also a no small flora, when probiotics dominance（Account for 80% or more of sum）, human body then keeps fit state,
Otherwise inferior health or unhealthy status are in.Bacillus acidi lactici is considered as safest strain, and most representative prebiotic
Therefore bacterium increases profitable strain, beneficial to colony balance, strengthen immunity and resistance in recovery vagina, while can maintain
Acid vagina environment (pH≤4.5, mostly in 3.8-4.4), inhibits the growth of other pathogens, and it is thin effectively to prevent female reproductive system
Bacterium infects.
The present invention is compared with similar prior art products, advantage of the invention is that being directed to female private part easy infection pathogenic bacteria
And cause Dysbiosis, mucous membrane secreting function destroy, vaginal relaxation, it is dry and astringent and lead to gynaecological imflammation develop formula.
The present invention has following features：
1）The present invention is arranged in pairs or groups using a variety of herbaceous plant Chinese herbal medicine extract science, and with bactericidal antiphlogistic, desinsection is antipruritic, heat-clearing is dry
It is wet.To staphylococcus aureus, Escherichia coli, Candida albicans bacteriostasis rate up to 99.9% or more.To damp and hot, abnormal leucorrhea, private parts
Moist itch has good mitigation.
2）The present invention does not add preservative and hormone, does not stimulate mildly, without any side effects to no damage to human body.It can self
Inhibit virus and the activity of bacterium, it is final to realize prevention to vaginitis, uterine neck to reach the survival for intervening virus and bacterium
Purpose scorching, palace prohibitions is rotten to the corn, HPV viruse infects, allows patient to break away from the toxic side effect of drug.
3）Science of the present invention arranges in pairs or groups Bacillus acidi lactici to promote the growth and breeding of vagina probiotics, adjusts vaginal flora balance
And acid-base balance, intrauterine mucosal tissue is nourished and repaired, itself secreting function is promoted, reduces gynaecological imflammation recurrence rate.
4）The present invention increases collagen peptide helper cell and is manufactured into collagen, promotes cell tissue normal growth, more
The cell component of new outmoded aging, displacement exclude intracellular toxin, and uterus is discharged and vagina accumulates old cast-off cells for a long time
And clot, endometrium and the remaining rubbish of vagina and toxin, benefiting qi and nourishing blood are removed, compact foster nest, activates the secretion of ovary, promotees
Into female estrogen normal secretions, makes loose vagina tissue consolidation, restores elasticity of skin, slow down aging.
Monarch structure is clear between each raw material in inventive formulation, and the monarch and his subjects are orderly, mutually taken the photograph with a surname.
Kuh-seng, the tuber of stemona are the drugs for playing curative effect in formula to gynaecological imflammation, are monarchs drug in a prescription.Kuh-seng heat-clearing and damp-drying drug,
Desinsection is antipruritic, antibacterial anti-inflammatory, antiallergic, antitumor；The tuber of stemona has killing to make mosquitos and flies larva, pinworm, head louse, clothing lice and bedbug etc.
With；The two forms resultant force, more efficient than being used alone, and promotes that desinsection is antipruritic, the enhancing of the antibacterial anti-inflammatory efficacy of a drug, disturbs and itches to private parts,
The gynaecological imflammations such as trichomonas vaginitis are significant in efficacy, have to pathogenic bacteria such as staphylococcus aureus, Escherichia coli, Candida albicans
Stronger killing effect.
Frutus cnidii, Cortex Phellodendri, Chinese prickly ash are that the drug to gynaecological imflammation curative effect is assisted and reinforced in formula, are ministerial drugs.It is being formulated
Middle frutus cnidii mainly assists and reinforcement desinsection is antipruritic, and eliminating dampness wind-dispelling, to leukorrhea with reddish discharge, private parts, which is disturbed, itches, trichomonas vaginitis etc.
The effect of gynaecological imflammation, while to rubella, eczema, pruitus, uterus cold infertile etc. and disease are effective in cure；Cortex Phellodendri mainly assist and
Reinforce heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of with diseases such as lower pruritus vulvae, while to sore swollen toxin, eczema wet sore, puckery pain of heat gonorrhea etc. is simultaneous
Disease is effective in cure；Chinese prickly ash is for assisting and reinforcing bacterio static itching-relieving, and dehumidify cold dispelling, desinsection detoxifying effect.
Monarch drug in a prescription ministerial drug science is arranged in pairs or groups, synergistic effect, not only antibacterial anti-inflammatory, the enhancing of desinsection antipruritic effect, and forms wide spectrum
The activity of bacteriostasis, energy self suppression virus and bacterium, to reach the survival for intervening virus and bacterium, without adding anti-corrosion
Agent can play the role of sterilization and anticorrosion, without any side effects to no damage to human body, final to realize to vaginitis, cervicitis, palace
Prohibit many disease treating and preventing effects such as rotten to the corn, HPV viruse infection.
But while killing harmful bacteria, probiotics is also easy to be killed, in the dust, microecology in vaginas balance will for probiotics
It is destroyed, pathogenic bacteria or foreign pathogens will avail oneself of the opportunity to get in, it will cause vaginal pH to increase, mucosal secretions function is by broken
It is bad, often there is pudendal pruritus, leucorrhea increasing, there are the symptoms such as peculiar smell, may result in gynaecological imflammation recurrence.
In order to avoid intravaginal microecology in vaginas is unbalance, probiotics is required supplementation with to safeguard that microecology in vaginas balances, and it is cloudy
Most important probiotics is Bacillus acidi lactici in road secretion.So Bacillus acidi lactici is adjutant in formula.Bacillus acidi lactici is to be present in
Probiotics in mankind's body, it can generate some antimicrobial substances in the vagina of healthy women, and control vaginal flora is flat
Weighing apparatus and acid-base balance.In the factor for maintaining microecology in vaginas balance, estrogen, Bacillus acidi lactici and vagina acid-base degree are played to pass
Important role.Estrogen makes vagina epithelium hyperplasia thicken and is rich in glycogen, increases the resistance to pathogen, glycogen is in vagina
It is decomposed into lactic acid under Effect of Lactobacillus, maintains the normal acidic environment of vagina.Therefore, increase profitable strain, beneficial to recovery female
Property intravaginal colony balance, strengthen immunity and resistance inhibit the growth of other pathogens, prevent reproductive system bacterium infection
And cause many diseases such as vaginitis, cervicitis, cervical erosion, HPV viruse infection.
Pathogenic bacteria kill, and probiotics is protected, and microecology in vaginas reaches balance, need benefiting qi and nourishing blood in next step, living
Blood stagnation resolvation, palace of the Qing Dynasty toxin expelling, and then reach convergence and compact, the purpose of anti-aging.
Safflower, lanatechead saussurea herb with flower, witch hazel, collagen peptide, hydroxyethyl cellulose are to make medicine in formula.Safflower, saussurea involucrata
Flower benefiting qi and nourishing blood, promoting blood circulation and removing blood stasis, cold dispelling warm the womb moisten yin-nourishing, palace of the Qing Dynasty toxin expelling；Witch hazel hemostasia and detumescence, healing of wound, consolidation are received
It holds back；Collagen peptide can pass through vagina mucosa and cell combination, helper cell are manufactured into collagen, promote cell tissue normal
Growth updates the cell component of outmoded aging, and displacement excludes intracellular toxin, improves vagina living environment and promotes tissue
Metabolism enhances blood circulation, promotes vagina contraction, makes loose vagina tissue consolidation, restores elasticity, slows down aging；Most
Afterwards by the thickening of hydroxyethyl cellulose, suspension effect, reaches and close the gelling agent to work well with vaginal mucosal tissue lotus root.
The present invention is coordinated using pharmacology and scientific compatible combination, diagnosis and treatment based on an overall analysis of the illness and the patient's condition guide drugs to illness station, significant effect, and method letter
Just, economy and facility, the course for the treatment of is also short, therefore is easy to face wide utilization, can kill vagina harmful pathogenic bacteria and protect vagina beneficial bacterium
Group adjusts microecology in vaginas balance, improves female reproductive system immunity, at the same also can palace of the Qing Dynasty toxin expelling, to repair vaginal injury viscous
Film, improvement vaginal relaxation are dry and astringent, convergence is compacted.To menoxenia, closed dysmenorrhea, under uterine bleeding band, prolonged lochia, the stasis of blood
Blood is had a pain, cervical erosion, and the diseases such as lumbago due to the kidney deficiency have preferable mitigation, is a kind of health-care protective of the fine prophylaxis of gynaecological disorders of energy
Manage articles for use.
That the present invention overcomes prior art products is strong to vaginal mucosa irritation, destroys acid vagina environment colony balance,
The problem of effective cannot preventing external source pathogenic bacteria from immersing.Vagina harmful pathogenic bacteria can be killed and protect vagina beneficial bacterium
Group adjusts microecology in vaginas balance, improves female reproductive system immunity, at the same also can palace of the Qing Dynasty toxin expelling, to repair vaginal injury viscous
Film, improvement vaginal relaxation are dry and astringent, convergence is compacted, good combination property.
Specific implementation mode
Embodiment 1
(1) by 2.0 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 78 DEG C；
(2) by 4.0 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 3.0
Part, 2.0 parts of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）3.5 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 3.5
Part, Chinese prickly ash（Zanthoxylumbungeanum）3.0 parts of berry extract, 2.6 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2.0 parts of extract, continues to stir, and cool down
To 40 DEG C；
(3) hamamelis is added（Hamamelis virginiana）1.5 parts of leaf extract, 2.8 parts of Bacillus acidi lactici, stirring are equal
It is even, it stands and excludes bubble, gelling agent is made.
Embodiment 2
(1) by 2.0 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 80 DEG C；
(2) by 4.5 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 3.5
Part, 2.5 parts of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）4.0 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 4.2
Part, Chinese prickly ash（Zanthoxylumbungeanum）2.5 parts of berry extract, 3.0 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2.5 parts of extract, continues to stir, and cool down
To 45 DEG C；
(3) hamamelis is added（Hamamelis virginiana）2.0 parts of leaf extract, 2.5 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
Embodiment 3
(1) by 1.9 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 85 DEG C；
(2) by 4.5 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 3.5
Part, 2.3 parts of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）4.5 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 4.0
Part, Chinese prickly ash（Zanthoxylumbungeanum）2.8 parts of berry extract, 3.0 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2.7 parts of extract, continues to stir, and cool down
To 48 DEG C；
(3) hamamelis is added（Hamamelis virginiana）2.8 parts of leaf extract, 3.5 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
Embodiment 4
(1) by 2.0 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 82 DEG C；
(2) by 5.0 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 4.2
Part, 2.5 parts of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）4.0 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 4.5
Part, Chinese prickly ash（Zanthoxylumbungeanum）3.0 parts of berry extract, 3.0 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2.0 parts of extract, continues to stir, and cool down
To 50 DEG C；
(3) hamamelis is added（Hamamelis virginiana）3.0 parts of leaf extract, 4.0 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
Embodiment 5
(1) by 2.0 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 85 DEG C；
(2) by 5.5 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 4.5
Part, 3.0 parts of collagen peptide are added with after 5 parts of deionized water dissolvings in step (1) respectively, are stirred evenly, and cnidium monnieri is added
（Cnidium monnieri）4.5 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 4.5
Part, Chinese prickly ash（Zanthoxylumbungeanum）3.6 parts of berry extract, 3.5 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 2.5 parts of extract, continues to stir, and cool down
To 45 DEG C；
(3) hamamelis is added（Hamamelis virginiana）3.0 parts of leaf extract, 4.5 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
Embodiment 6
(1) by 2.0 parts of addition deionized waters of hydroxyethyl cellulose, stirring makes it be uniformly dispersed, and is heated to 80 DEG C；
(2) by 6.0 parts of kuh-seng (Sophora flavescens) root extract, the tuber of stemona (Stemonae Radix) extract 4.5
Part, 3.0 parts of collagen peptide are added after using 5kg deionized water dissolvings respectively in step (1), stir evenly, and cnidium monnieri is added
（Cnidium monnieri）5.0 parts of berry extract, Cortex Phellodendri（Cortex Phellodendri Chinensis）Extract 4.5
Part, Chinese prickly ash（Zanthoxylumbungeanum）4.0 parts of berry extract, 3.5 parts of safflower (Crocussativus) extract,
Lanatechead saussurea herb with flower (Saussurea involucrata (Kar.etKir.) Sch.-Bip) 3.0 parts of extract, continues to stir, and cool down
To 45 DEG C；
(3) hamamelis is added（Hamamelis virginiana）3.0 parts of leaf extract, 4.5 parts of Bacillus acidi lactici, stirring
Uniformly, it stands and excludes bubble, gelling agent is made.
Product physical and chemical index of the present invention is examined：
1 ~ 6 product physical and chemical index of the embodiment of the present invention is examined by method as defined in standard Q/KBJ 002, and inspection result is shown in Table 1.
Table 1
Product Micro biological Tests of the present invention：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disposable Sanitary Accessory sanitary standard GB15979-2002》Method as defined in Appendix B carries out
Microbiological indicator is examined, and survey report number 201700000404, inspection result is shown in Table 2.
Table 2
Conclusion：The product microbiological indicator inspection result meets《Disposable Sanitary Accessory sanitary standard
GB15979-2002》Requirement.
Product vaginal mucosa irritation test of the present invention：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disinfection technology standard》（Version in 2002）2.3.5 regulation carries out vaginal mucosa irritation test, inspection
Test report number 201700000405.Vaginal mucosa irritation test operating method is as follows：
Experimental animal quantity and grouping：It is divided into contamination group and control group, every group 3.
Operation sequence：Rabbit is faced upward fixation, exposure perineum and introitus, by conduit（The children that length is 8cm or so use
The syringe of catheter and 5ml connect）Vagina is gently inserted into after being moistened with tested material（4cm）It is used in combination syringe to be slowly injected into
2ml tested materials, withdrawal conduit.Control animals physiological saline makees same processing.
After contamination for 24 hours, animal is put to death using aeroembolism method, cuts open the belly and take out complete vagina, longitudinally splits, whether visually observe has
It phenomena such as hyperemia, oedema, is then placed in 10% formalin solution and fixes 48h, choose the both ends of vagina and intermediate 3 positions
Tissue film-making, HE dyeing, carry out histopathological examination.
Evaluation of result method：Histopathological examination result is evaluated；By the thorn at 3 animals of test group, 3 positions
Swash reaction integral be added after again divided by observation sum（Number of animals х 3）, obtain the average product of test group vaginal mucosa stimulate the reaction
Point.Control group methods of marking is same as above.Test group average integral is subtracted into control group average integral and obtains the laggard assassination of stimulus index
Swash strength grading.Test result, the scoring of vaginal mucosa stimulate the reaction, which summarizes, is shown in Table 3.
Table 3
Note：1）The stimulate the reaction integral addition/observation at 3 positions of average integral=3 animal is total (number of animals х 3)；
2）Stimulus index=contamination group average integral-negative control group average integral.
Conclusion：The product is 0.22 to the stimulus index of rabbit vagina mucous membrane, and vaginal mucosa stimulate the reaction intensity is no the moon
Mucous membrane irritation.
The pH value of product of the present invention is tested：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disinfection technology standard》（Version in 2002）2.2.1.4 regulation carries out pH value inspection, and survey report is compiled
Numbers 201700000406.Inspection result is shown in Table 4.
Table 4
Table 4
Conclusion：The product pH value average value is 4.2.
Product bacteriostasis property (Escherichia coli, staphylococcus aureus) experiment of the present invention：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disposable Sanitary Accessory sanitary standard GB15979-2002》Method as defined in appendix C carries out
Bacteriostasis property（Escherichia coli, staphylococcus aureus）Experiment, survey report number is 201700000489.It is tried through 3 repetitions
It tests, action time is respectively that the bacteriostasis rate inspection result of 2min, 5min, 10min, 20min are shown in Table 5.
Table 5
Conclusion：The product is tested through 3 repetitions, and bacteriostasis rate average value is equal>99.9%, the results showed that the invention is to large intestine bar
Bacterium, staphylococcus aureus have stronger bacteriostasis.
Product bacteriostasis property of the present invention（Candida albicans）Experiment：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disposable Sanitary Accessory sanitary standard GB15979-2002》Method as defined in appendix C carries out
Bacteriostasis property（Candida albicans）Experiment, survey report number is 201700000490.It is tested through 3 repetitions, action time point
Not Wei the bacteriostasis rate inspection result of 2min, 5min, 10min, 20min be shown in Table 6.
Table 6
Conclusion：The product is tested through 3 repetitions, and bacteriostasis rate average value is equal>99.9%, the results showed that white is read in the invention
Pearl bacterium has stronger bacteriostasis.
The stability of product of the present invention（Bacteriostasis property）Experiment：
By 6 product of the embodiment of the present invention（Inspection name of product：Water cottonrose hibiscus orchid is compacted gel）Entrust Ningbo Entry-Exit Inspection and Quarantine Bureau
It presses inspection and quarantine technique center《Disposable Sanitary Accessory sanitary standard GB15979-2002》Method as defined in appendix C carries out
Stability test（Bacteriostasis property）, survey report number is 201700000490.
90 days in 37 DEG C of constant temperature and humidity incubators of test temperature, relative humidity 80%.Before and after 90 days, tried respectively through 3 repetitions
It tests, action time is respectively that the bacteriostasis rate inspection result of 2min, 5min, 10min, 20min are shown in Table 7.
Table 7
Conclusion：The product is after 37 DEG C are stored 90 days, and appearance and packaging are without significant change；To Candida albicans after storing 90 days
Bacterium has stronger bacteriostasis.
Product clinical test and analysis of the present invention：
Select 90 female gynecological inflammatory patients, cardinal symptom：Bacterial vaginitis, trichomonas vaginitis, colpomycosis,
Cervical erosion, abnormal leucorrhea have peculiar smell, pruritus vulvue, pain or intercourse pain etc..Visible vulva and vagina mucosa go out to fill when inspection
Blood.Distinguish visible trichomonad or fungi, bacterial vaginitis BV when trichomonas or colpomycosis patient's vaginal fluid microscopy
Check that the positive, pH value are higher（5.8 or more pH value）.
By 6 product of the embodiment of the present invention（5g/ branch）Carry out clinical application.Application method is 1 every time one time a day.Every night
Before sleeping after cleaning vulva, the cap of gel device front end is removed, gel device rear end is inserted into as push rod, releases gel in intravaginal
Portion.
Primary, light patient's recovery from illness is checked after 3 days using the present invention, and pH value is normal（pH：3.8~4.4）；Weight patient symptom subtracts
Gently, leukorrhea amount is reduced, and pruritus vulvue is alleviated, and vagina hyperemia disappears, and pH value is normal.It is checked again after 6 days once, patient fullys recover from an illness
More, pH value is normal, and uterine neck is smooth, and vaginal dryness is alleviated.After 15 days, most of the patient feels vagina compacts, soft, succulence, property
Life is harmonious, of pink and healthy-looking.
Conclusion：The present invention it is a kind of it is antibacterial, adjust microecological balance and compact gel by clinic application, bactericidal antiphlogistic cure rate
Up to 99% or more；PH value 100% restores normal（pH：3.8~4.4）；Vagina contraction rate is up to 95% or more.
Claims (2)
1. a kind of gel process for preparing that compacts that is antibacterial, adjusting microecological balance：
Raw material is by weight ratio
Hydroxyethyl cellulose is added in deionized water for 1 ~ 3 part, stirring makes it be uniformly dispersed, and is heated to 75 DEG C ~ 85 DEG C；
By 4 ~ 6 parts of kuh-seng root extract, 3 ~ 5 parts of Radix Stemonae extract, 1 ~ 3 part of collagen peptide respectively with 5 parts of deionized water dissolvings
It is added in step (1) afterwards, stirs evenly, stir evenly, 3 ~ 5 parts of common cnidium fruit P.E, 3 ~ 5 parts of phellodendron extract, Chinese prickly ash fruit is added and carries
2 ~ 4 parts of object, 2 ~ 4 parts of safranine flower extract, 2 ~ 3 parts of Herba Saussureae Involueratae extract are taken, continues to stir, and is cooled to 45 DEG C ~ 55 DEG C；
(3) 1 ~ 3 part of hamamelis leaf extract, 2 ~ 5 parts of Bacillus acidi lactici is added, stirs evenly, stands and excludes bubble, is made
Gelling agent.
2. the gel that compacts that is antibacterial as made from claim 1 method, adjusting microecological balance.
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