CN103340974A - Oral care aerosol and preparation method thereof - Google Patents

Abstract

The invention discloses an oral care aerosol and a preparation method thereof. The oral care aerosol comprises the following components in parts by weight: 5-15g of isatis roots, 3-7g of borneol, 5-15g of honeysuckle, 5-15g of liquorice, 5-15g of radix scutellariae, 2-8g of dried alum and the like. The preparation method comprises the following steps of material selecting, extracting solution mixing and the like. The oral care aerosol disclosed by the invention is simple in preparation method, contains medicinal plant extracts with good taste acceptability and functional components capable of protecting the mucosa, is natural and pure in taste, not only suitable for use when a person feels discomfortable in the oral cavity, but also suitable for daily oral care, and can be used for effectively cleaning the oral cavity and teeth, relieving discomfortable symptoms such as toothache, gum bleeding, oral ulcer, chronic gingisitis, periodontitis, swollen sore throat and the like so as to protect the health of the oral cavity.

Description

A kind of mouth care aerosol and preparation method thereof

Technical field

The present invention relates to a kind of mouth care medicine and preparation method thereof, relate to a kind of mouth care aerosol and preparation method thereof specifically.

Background technology

At present the ora, disinfectant used clinically is mainly by iodine class, antibiotics, acid-base class or hibitane class.The iodide ion oxidability is extremely strong, but is a kind of unstable material, is easy to other material again and produces change color, produces precipitation simultaneously, and sterilization also decreases; Antibiotics such as nitrofural, mouthfeel difference and be easy to generate biocidal property; Its cost height of acid-base class or hibitane class, low, the poor stability of germicidal efficiency, toxic, corrosivity or penetrating odor have certain damage to oral mucosa, and the oral cavity stink can't be eliminated, also need a large amount of flushing with clean water after the sterilization, if mistake gulps down and will cause certain damage.

Summary of the invention

The technical problem to be solved in the present invention is to overcome above-mentioned defective, and a kind of safety and stability, better, the heat-clearing and toxic substances removing mouth care aerosol of mouthfeel are provided;

Another object of the present invention provides a kind of manufacture method of mouth care aerosol.

For addressing the above problem, the technical solution adopted in the present invention is:

A kind of mouth care aerosol is characterized in that, described mouth care aerosol is made up of the component of following weight portion:

Radix Isatidis 5-15g, Borneolum Syntheticum 3-7g, Flos Lonicerae 5-15g, Radix Glycyrrhizae 5-15g, Radix Scutellariae 5-15g, dried Alumen 2-8g, Ramulus Salicis Babylonicae 10-20g, Fructus Forsythiae 5-15g, Herba Taraxaci 5-15g, Herba Asari 5-15g, Herba Houttuyniae 5-15g, Catergen-8g, benzethonium chloride 0.01-0.5g, Polyethylene Glycol 1-3g, sorbitol 0.1-1g, glycerol 1-5g, ethanol 2-5g, Oleum menthae 0.1-0.5g, sodium bicarbonate 0.1-1g, distilled water 150-250g.

A kind of manufacture method of mouth care aerosol is characterized in that, described manufacture method comprises the steps:

A chooses an amount of Radix Isatidis, Flos Lonicerae, Radix Glycyrrhizae, Radix Scutellariae, dried Alumen, Ramulus Salicis Babylonicae, Fructus Forsythiae, Herba Taraxaci, Herba Asari, Herba Houttuyniae, cleans, pulverizes, and puts adding distil water extraction secondary in the extraction pot, 50-70 minute for the first time, 30-50 minute for the second time, extracting liquid filtering, concentrated obtained extracting solution;

B chooses an amount of Borneolum Syntheticum by weight and pulverizes, and is added in the ethanol, stirs evenly, and obtains mixed liquor;

C joins mixed liquor and vitamin C, benzethonium chloride, Polyethylene Glycol, sorbitol, glycerol, Oleum menthae, sodium bicarbonate in the extracting solution of steps A gained by weight, and adds distilled water surplus, fully mixes, and packing obtains the mouth care collutory;

D encloses the mouth care collutory fill that makes in the aerosol bottle, obtains the mouth care aerosol.

Wherein each component effect and effect are as follows:

Radix Isatidis has the effect of heat clearing away, detoxifcation, removing heat from blood, sore-throat relieving, control maculae caused by violent heat pathogen, the headache of high heat, major part pestilence, crimson tongue purple secretly, scarlet fever, erysipelas, mumps, sore throat, skin ulcer are swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, the skin ulcer rash can be prevented and treated epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.

Borneolum Syntheticum has the effect of the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, can lead to all keys, the stagnated fire of loosing, removing nebula make eye bright, reducing swelling and alleviating pain, control calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order also nebula film, enterobiasis.

Flos Lonicerae has heat-clearing and toxic substances removing, promoting blood circulation and detumescence, pain relieving, wind-damp dispelling effect, have antibacterial and bactericidal action to various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi, streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus, dysentery bacterium, Streptococcus mutans etc., influenza virus, Orphan virus, herpesvirus, leptospira equalization are all had certain inhibitory action.

Radix Glycyrrhizae has detoxifcation, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer, and Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.

Radix Scutellariae has antibiotic, antivirus action has inhibitory action to multiple gram positive bacteria, gram-negative bacteria, pathogenic dermatophytes, can suppress influenza virus, hepatitis B virus.

Dried Alumen has the effect of expectorant, dampness, antidiarrheal, hemostasis, detoxifcation, parasite killing, controls that sore throat, remorse saliva are stopped up very, hepatitis, jaundice, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, extreme misery insect bite.

Ramulus Salicis Babylonicae have dispel the wind, the effect of diuresis, pain relieving, detumescence, control infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.

Fructus Forsythiae has the effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, and multiple Grain-positive and negative bacteria are all had inhibitory action, and experiment in vitro shows that the alcohol extract of Fructus Forsythiae has anti-leptospira effect; Embryo Gallus domesticus in vitro tests proof Fructus Forsythiae has inhibitory action to Asia influenza A virus, rhinovirus-17 type; Semen Fructus Forsythiae volatile oil also has tangible antibacterial action external to staphylococcus aureus, also has obviously to suppress the staphylococcus aureus plasma-coagulase to the consolidation of blood plasma; The staphylococcus aureus that infects in the rabbit blood is obviously reduced.1: 5 Fructus Forsythiae water logging agent has some inhibitory action to star-shaped nocardia in vitro.

Herba Taraxaci has heat clearing away sterilization, eliminating carbuncle eliminating stagnation, antibiotic effect, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus Resistant strain, Hemolytic streptococcus in vitro, and Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had certain bactericidal action; 1: 400 extracting solution of Herba Taraxaci can suppress tulase in vitro; 1: 80 Herba Taraxaci water decoction can delay ECH011 virocyte pathological changes; Taraxol extract 31mg/kg can kill leptospira; The water logging agent has inhibitory action to the various skin fungus; Decoct gives rat oral, absorbs well, can keep certain antibacterial action in the urine.

Herba Asari have dispel the wind, cold expelling, Hang Shui, the effect of having one's ideas straightened out, control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.

Herba Houttuyniae has the effect of heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome.

Vitamin C has the synthetic of promotion collagen protein, prevents the effect of gingival hemorrhage.

Benzethonium chloride generally is used as disinfection sanitizer, and benzethonium chloride is novel antiseptic, has surface activity preferably, is widely used in daily use chemicals, medicine and other fields is done anticorrosion, antibacterial, and benzethonium chloride is stable, and aqueous solution can pressure sterilizing.

Nontoxic, the nonirritant of Polyethylene Glycol has good water-solubility, and with many organic matter components good intermiscibility is arranged, and the present invention is as solubilizing agent.

Sorbitol has moisture absorption, and water retention is the sugariness energy, is used as sweeting agent among the present invention.

Glycerol is aspect medical science, in order to produce various preparations, solvent, hygroscopic agent, antifreezing agent and sweeting agent, ingredients externally-applied ointment or suppository etc.

The Oleum menthae suffering, cold, nontoxic, aromatic drug, remedium corrigens and carminative can be used for skin or mucosa and produce refrigerant sense and be not suitable for to alleviate, main pain, the present invention is as essence.

Sodium bicarbonate is in the present invention as the pH value regulator.

Ethanol is colourless, transparent, has the liquid of peat-reek, and density is littler than water, can dissolve each other with any ratio with water, and be a kind of important solvent, can dissolve multiple Organic substance and inorganic matter, be used for dissolving Borneolum Syntheticum among the present invention.

Take the mode of clinical trial, further specify curative effect of the present invention, have the patient that 200 examples have the voluntary trial edition invention of typical various oral cavities malaise symptoms mouth care aerosol, be equally divided into two groups, wherein embodiment group 100 routine patients, wherein male 53 examples, woman's 47 examples, the oldest 65 years old, minimum 19 years old, 42 years old mean age, medical history is the longest 2 years, in the shortest 2 weeks, Therapeutic Method is for to spray into the mouth care aerosol that makes in the embodiment of the invention, every six hours once in the oral cavity; Matched group 100 routine patients, male 51 examples wherein, women 49 examples, the oldest 64 years old, minimum 20 years old, 42 years old mean age, medical history was the longest 2 years, and in the shortest 2 weeks, Therapeutic Method is gargled for using 0.02% furacilin solution, every six hours once; These two groups of personnel's cardinal symptoms are oral ulcer, laryngopharynx swelling and pain, gingival hemorrhage or gingival swelling and pain and halitosis.These two groups of patients use care aerosol agent of the present invention 7 days respectively, and two groups of patient medical record are there was no significant difference statistically, each symptom number of embodiment group patient and observation of curative effect result such as table 1, and each symptom number of matched group patient and treatment observed result such as table 2:

Table 1

Table 2

The agent of this care aerosol is to oral ulcer class effective percentage 88.6%, laryngopharynx swelling and pain class 83.3%, gingival hemorrhage or gingival swelling and pain class effective percentage 81.8%, halitosis class effective percentage 92.3% as shown in Table 1; Use the treatment of 0.02% furacilin solution to oral ulcer class effective percentage 71.1%, laryngopharynx swelling and pain class 60.0%, gingival hemorrhage or gingival swelling and pain class effective percentage 55.5%, halitosis class effective percentage 60.9% as shown in Table 2, the every data of the present invention significantly are better than the generic physiological brine treatment, clinical trial shows, use this care aerosol agent experimenter to feel that all the oral cavity is comfortable, non-stimulated abnormal smells from the patient, good mouthfeel, remarkable to the oral cavity nursing efficacy, toxic and side effects is little.

Mouth care aerosol of the present invention; manufacture method is simple; composition comprises the functional component of the good medicinal plant extract of mouthfeel acceptance and protection mucosa; mouthfeel is natural pure; both be fit to the oral cavity and do not used in good time, also suitable daily mouth care, effectively cleaning oral cavity and tooth; alleviate malaise symptoms such as toothache, gingival hemorrhage, oral ulcer, gingivitis, periodontitis, laryngopharynx swelling and pain, the health in protection oral cavity.

The specific embodiment

Embodiment 1: a kind of mouth care aerosol, and described mouth care aerosol is made up of the component of following weight portion:

Radix Isatidis 10g, Borneolum Syntheticum 5g, Flos Lonicerae 10g, Radix Glycyrrhizae 10g, Radix Scutellariae 10g, dried Alumen 5g, Ramulus Salicis Babylonicae 15g, Fructus Forsythiae 10g, Herba Taraxaci 10g, Herba Asari 10g, Herba Houttuyniae 10g, vitamin C 5g, benzethonium chloride 0.24g, Polyethylene Glycol 2g, sorbitol 0.4g, glycerol 3g, ethanol 3g, Oleum menthae 0.3g, sodium bicarbonate 0.4g, distilled water 200g.

A kind of manufacture method of mouth care aerosol, described manufacture method comprises the steps:

A chooses an amount of Radix Isatidis, Flos Lonicerae, Radix Glycyrrhizae, Radix Scutellariae, dried Alumen, Ramulus Salicis Babylonicae, Fructus Forsythiae, Herba Taraxaci, Herba Asari, Herba Houttuyniae, cleans, pulverizes, and puts adding distil water extraction secondary in the extraction pot, 50-70 minute for the first time, 30-50 minute for the second time, extracting liquid filtering, concentrated obtained extracting solution;

B chooses an amount of Borneolum Syntheticum by weight and pulverizes, and is added in the ethanol, stirs evenly, and obtains mixed liquor;

C joins mixed liquor and vitamin C, benzethonium chloride, Polyethylene Glycol, sorbitol, glycerol, Oleum menthae, sodium bicarbonate in the extracting solution of steps A gained by weight, and adds distilled water surplus, fully mixes, and packing obtains the mouth care collutory;

D encloses the mouth care collutory fill that makes in the aerosol bottle, obtains the mouth care aerosol.

Embodiment 2: a kind of mouth care aerosol, and described mouth care aerosol is made up of the component of following weight portion:

Radix Isatidis 5g, Borneolum Syntheticum 3g, Flos Lonicerae 5g, Radix Glycyrrhizae 5g, Radix Scutellariae 5g, dried Alumen 2g, Ramulus Salicis Babylonicae 10g, Fructus Forsythiae 5g, Herba Taraxaci 5g, Herba Asari 5g, Herba Houttuyniae 5g, Catergen g, benzethonium chloride 0.01g, Polyethylene Glycol 1g, sorbitol 0.1g, glycerol 1g, ethanol 2g, Oleum menthae 0.1g, sodium bicarbonate 0.1g, distilled water 150g.

A kind of manufacture method of mouth care aerosol, described manufacture method comprises the steps:

A chooses an amount of Radix Isatidis, Flos Lonicerae, Radix Glycyrrhizae, Radix Scutellariae, dried Alumen, Ramulus Salicis Babylonicae, Fructus Forsythiae, Herba Taraxaci, Herba Asari, Herba Houttuyniae, cleans, pulverizes, and puts adding distil water extraction secondary in the extraction pot, 50-70 minute for the first time, 30-50 minute for the second time, extracting liquid filtering, concentrated obtained extracting solution;

B chooses an amount of Borneolum Syntheticum by weight and pulverizes, and is added in the ethanol, stirs evenly, and obtains mixed liquor;

C joins mixed liquor and vitamin C, benzethonium chloride, Polyethylene Glycol, sorbitol, glycerol, Oleum menthae, sodium bicarbonate in the extracting solution of steps A gained by weight, and adds distilled water surplus, fully mixes, and packing obtains the mouth care collutory;

D encloses the mouth care collutory fill that makes in the aerosol bottle, obtains the mouth care aerosol.

Embodiment 3: a kind of mouth care aerosol, and described mouth care aerosol is made up of the component of following weight portion:

Radix Isatidis 15g, Borneolum Syntheticum 7g, Flos Lonicerae 15g, Radix Glycyrrhizae 15g, Radix Scutellariae 15g, dried Alumen 8g, Ramulus Salicis Babylonicae 20g, Fructus Forsythiae 15g, Herba Taraxaci 15g, Herba Asari 15g, Herba Houttuyniae 15g, vitamin C 8g, benzethonium chloride 0.5g, Polyethylene Glycol 3g, sorbitol 1g, glycerol 5g, ethanol 5g, Oleum menthae 0.5g, sodium bicarbonate 1g, distilled water 250g.

A kind of manufacture method of mouth care aerosol, described manufacture method comprises the steps:

A chooses an amount of Radix Isatidis, Flos Lonicerae, Radix Glycyrrhizae, Radix Scutellariae, dried Alumen, Ramulus Salicis Babylonicae, Fructus Forsythiae, Herba Taraxaci, Herba Asari, Herba Houttuyniae, cleans, pulverizes, and puts adding distil water extraction secondary in the extraction pot, 50-70 minute for the first time, 30-50 minute for the second time, extracting liquid filtering, concentrated obtained extracting solution;

B chooses an amount of Borneolum Syntheticum by weight and pulverizes, and is added in the ethanol, stirs evenly, and obtains mixed liquor;

C joins mixed liquor and vitamin C, benzethonium chloride, Polyethylene Glycol, sorbitol, glycerol, Oleum menthae, sodium bicarbonate in the extracting solution of steps A gained by weight, and adds distilled water surplus, fully mixes, and packing obtains the mouth care collutory;

D encloses the mouth care collutory fill that makes in the aerosol bottle, obtains the mouth care aerosol.

Mouth care aerosol of the present invention; manufacture method is simple; composition comprises the functional component of the good medicinal plant extract of mouthfeel acceptance and protection mucosa; mouthfeel is natural pure; both be fit to the oral cavity and do not used in good time, also suitable daily mouth care, effectively cleaning oral cavity and tooth; alleviate malaise symptoms such as toothache, gingival hemorrhage, oral ulcer, gingivitis, periodontitis, laryngopharynx swelling and pain, the health in protection oral cavity.

Claims (2)

1. a mouth care aerosol is characterized in that, described mouth care aerosol is made up of the component of following weight portion:

Radix Isatidis 5-15g, Borneolum Syntheticum 3-7g, Flos Lonicerae 5-15g, Radix Glycyrrhizae 5-15g, Radix Scutellariae 5-15g, dried Alumen 2-8g, Ramulus Salicis Babylonicae 10-20g, Fructus Forsythiae 5-15g, Herba Taraxaci 5-15g, Herba Asari 5-15g, Herba Houttuyniae 5-15g, Catergen-8g, benzethonium chloride 0.01-0.5g, Polyethylene Glycol 1-3g, sorbitol 0.1-1g, glycerol 1-5g, ethanol 2-5g, Oleum menthae 0.1-0.5g, sodium bicarbonate 0.1-1g, distilled water 150-250g.

2. the manufacture method of a mouth care aerosol is characterized in that, described manufacture method comprises the steps:

A chooses an amount of Radix Isatidis, Flos Lonicerae, Radix Glycyrrhizae, Radix Scutellariae, dried Alumen, Ramulus Salicis Babylonicae, Fructus Forsythiae, Herba Taraxaci, Herba Asari, Herba Houttuyniae, cleans, pulverizes, and puts adding distil water extraction secondary in the extraction pot, 50-70 minute for the first time, 30-50 minute for the second time, extracting liquid filtering, concentrated obtained extracting solution;

B chooses an amount of Borneolum Syntheticum by weight and pulverizes, and is added in the ethanol, stirs evenly, and obtains mixed liquor;

C joins mixed liquor and vitamin C, benzethonium chloride, Polyethylene Glycol, sorbitol, glycerol, Oleum menthae, sodium bicarbonate in the extracting solution of steps A gained by weight, and adds distilled water surplus, fully mixes, and packing obtains the mouth care collutory;

D encloses the mouth care collutory fill that makes in the aerosol bottle, obtains the mouth care aerosol.