CN104587138A - Buccal tablets for treating mouth ulcer and preparation method thereof - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to buccal tablets for treating mouth ulcer and a preparation method thereof. The buccal tablets for treating mouth ulcer are prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-6 parts of bezoar, 4-6 parts of borneol, 6-8 parts of liquorice root, 4-6 parts of alunite, 15-20 parts of medicine terminalia fruit, 10-12 parts of medcinal evodia fruit, 6-8 parts of raw arisaema consanguineum schott, 4-6 parts of ginseng, 10-12 parts of Chinese yam, 10-12 parts of bark of Chinese corktree, 6-8 parts of manchurian wildginger, 4-6 parts of honeysuckle flower, 15-20 parts of weeping forsythia capsule, 10-12 parts of wrinkled gianthyssop herb, 10-12 parts of costustoot, 8-10 parts of fortune eupatorium herb, 15-20 parts of Indian buead, 10-12 parts of medicated leaven, 6-8 parts of immature bitter orange, 15-20 parts of root of lobed kudzuvin and 10-12 parts of largehead atractylodes rhizome. The traditional Chinese medicine disclosed by the invention is short in treatment course and quick in action, can be used for astringing and promoting granulation, diminishing inflammation, relieving pain, and repairing mucosa, can be used for treating both symptoms and root causes, hardly causes relapse, also is relatively low in cost, ensures that the immunity of a patient can be enhanced for the whole life after the patient is treated for once; the traditional Chinese medicine disclosed by the invention is convenient to use and is suitable for popularization and application.

Description

A kind of buccal tablet for the treatment of oral ulcer and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of buccal tablet for the treatment of oral ulcer and preparation method thereof.

Background technology

Oral ulcer is clinical common multiple diseases, now generally adopt that Western medicine is for oral administration, quiet note or the treatment of the method such as intramuscular injection, oral medicinal herb, these method complex operations, the misery brought to sufferer is comparatively large, because medicine used is after absorbing, the competence exertion effect of skin ulcer face is run to again through blood, often prove effective slow, the course for the treatment of is long, weak curative effect, especially infant is due to difficulty of taking medicine, and more can make extend the course for the treatment of.

The Chinese medicine civilization of motherland is brilliant, of long standing and well established.The traditional Chinese medical science is thought: oral ulcer belongs to " aphtha ", " aphtha ", and how by bothering or overaction of the five emotions and eating and drinking without temperance, hot and suffocating fire-transformation, burning hot smoked dispute of burning forms, and the key of its pathogenesis is " hot and suffocating ".

Summary of the invention

According to above the deficiencies in the prior art, provide a kind of can the treatment mouth ulcer lozenge and preparation method thereof of reducing swelling and alleviating pain, determined curative effect rapidly.

A kind of buccal tablet for the treatment of oral ulcer disclosed in this invention; formulated by the raw material of Chinese medicine of following parts by weight: Calculus Bovis 4-6 part, Borneolum Syntheticum 4-6 part, Radix Glycyrrhizae 6-8 part, Alumen 4-6 part, Fructus Chebulae 15-20 part, Fructus Evodiae 10-12 part, Rhizoma Arisaematis 6-8 part, Radix Ginseng 4-6 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 10-12 part, Cortex Phellodendri 10-12 part, Herba Asari 6-8 part, Flos Lonicerae 4-6 part, Fructus Forsythiae 15-20 part, Herba Pogostemonis 10-12 part, Radix Aucklandiae 10-12 part, Herba Eupatorii 8-10 part, Poria 15-20 part, Massa Medicata Fermentata 10-12 part, Fructus Aurantii Immaturus 6-8 part, Radix Puerariae 15-20 part, Rhizoma Atractylodis Macrocephalae 10-12 part.

Treat a buccal tablet for oral ulcer, preferably formulated by the raw material of Chinese medicine of following parts by weight: yellow 5 parts, Borneolum Syntheticum 5 parts, 7 parts, Radix Glycyrrhizae, Alumen 5 parts, Fructus Chebulae 18 parts, Fructus Evodiae 11 parts, Rhizoma Arisaematis 7 parts, Cortex Phellodendri 11 parts, Radix Ginseng 5 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 11 parts, Herba Asari 7 parts, yellow 5 parts of gold silver, Fructus Forsythiae 18 parts, Herba Pogostemonis 11 parts, the Radix Aucklandiae 11 parts, Herba Eupatorii 9 parts, 18 parts, Poria, Massa Medicata Fermentata 11 parts, Fructus Aurantii Immaturus 7 parts, Radix Puerariae 18 parts, the Rhizoma Atractylodis Macrocephalae 11 parts.

A kind of preparation method for the treatment of the buccal tablet of oral ulcer, step is as follows: other raw materials except Radix Ginseng and RHIIZOMA DIOSCOREAE fr0m Henan of China are put into alembic, with its effective ingredient of extraction by steam distillation, after Radix Ginseng and Chinese yam powder are broken into fine powder, mix with cane sugar powder and put into extracting solution, stir and make soft material, cross 10-20 mesh sieve and obtain granule, after granule is added magnesium, put into tabletting machine, obtain the tablet of every sheet 0.15-0.18g.

Using method, each a slice, every day 3-5 time.

Pharmacology analysis:

Calculus Bovis: mildly bitter flavor is then sweet, cool in nature.Can be used for antipyretic, removing toxic substances, arresting convulsion.The disease such as Zhi Gaore coma for oral administration, demented, infantile convulsion, tic, external is controlled laryngopharynx swelling and pain, aphtha carbuncle, is treated toxication.

Borneolum Syntheticum: acrid in the mouth, hardship, be slightly cold, GUIXIN, liver, lung meridian, delicate fragrance a surname is loose, has the effect of refreshment improving acuity of vision and removing nebula of having one's ideas straightened out, cure mainly calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer hoodwinks key clearly, and sore throat is deaf, aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.

Radix Glycyrrhizae: sweet in the mouth, gas is put down, and property is delayed.Mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis.

Alumen: nature and flavor are sour and astringent, cold, can eat on a small quantity.Cure mainly: apoplexy; Epilepsy; Sore throat; Scabies eczema; Swollen ulcer drug; Burn due to hot liquid or fire; Aphtha of the mouth and tongue; Marginal blepharitis eye; Skin ulcer hemorrhoid pain; Metrorrhagia; Epistaxis; Bleeding due to trauma; Chronic diarrhea nine dysentery etc.

Fructus Chebulae: primary efficacy is astringed the lung; Astringing intestine to stop diarrhea; The therapeutic method to keep the adverse QI flowing downwards; Sore-throat relieving; Convergence, antidiarrheal; Resisting pathogenic microbes; Spasmolytic.Chronic diarrhea; Chronic dysentery; Proctoptosis; To breath with cough phlegmatic cough; Chronic cough aphonia.

Fructus Evodiae: hot in nature, bitter in the mouth is pungent, has the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, is used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache or gastralgia caused by cloudy turbid superinverse.

Rhizoma Arisaematis: property is bitter, pungent, temperature.Primary efficacy has drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.

Cortex Phellodendri: property is bitter, cold.Primary efficacy has heat clearing away, dampness, pathogenic fire purging, removing toxic substances.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.

Radix Ginseng: property is sweet, is slightly cold.Effect has strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Cure mainly weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse.Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves.Control impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, and frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies.

RHIIZOMA DIOSCOREAE fr0m Henan of China: invigorating spleen and reinforcing stomach is aid digestion, kidney nourishing and replenishing vital essence, lung benefiting cough-relieving, blood sugar lowering, life lengthening, anti-hepatic coma.

Herba Asari: cure mainly and dispel the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously, antitussive effect are better.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.

Fructus Forsythiae: bitter in the mouth, property is put down.Function cures mainly heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.

Herba Pogostemonis: nature and flavor and Gui Jingxin, tepor.Return spleen, stomach, lung meridian.Eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.Herba Pogostemonis has sterilizing function, and sucking a leaf can antihalitosis, keeps off infection, and can be used as antiseptic.Summer cooks congee with Herba Pogostemonis or drink-service of making tea, and to heat-damp in summer serious symptom, taste dampness, distension and fullness in the abdomen, limbs are heavily tired, and nausea and vomiting is effective.

The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, return spleen, stomach, liver, large intestine channel.The pain relieving of function warming middle-JIAO to promote flow of QI, strengthening the spleen to promote digestion intestinal stasis relieving.Cure mainly fullness and distention in the chest and hypochondrium, abdominal distention, tell and have loose bowels, heavy after dysentery, food stagnation does not disappear, anorexia, and colic of cold type is suffered from abdominal pain, edema, beriberi etc.

Herba Eupatorii: micro-pungent, flat.Enter spleen, stomach, lung meridian.For retention of dampness in middle-JIAO or spleen channel damp and hot, disease sees that gastral cavity abdomen painful abdominal mass is vexed, vomiting and nausea anorexia, sweet greasy sialism in mouth, halitosis, xerostomia thirst but no desire to drink; For summer-heat damp cold, disease sees fever with chills, headache, lossless, vague aching of limbs or pain, dizzy and headache, breast abdomen feeling of fullness, nausea, and tongue fur is white or yellow thick greasy, and promoting the production of body fluid to quench thirst, for quenching one's thirst.

Poria: sweet in the mouth, light, property is put down.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Massa Medicata Fermentata: sweet in the mouth is pungent, warm in nature, return spleen, stomach warp.Can invigorating the spleen and regulating the stomach, help digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.

Fructus Aurantii Immaturus: bitter in the mouth, pungent, cold in nature; Return spleen, stomach, liver, heart channel.Stop in effect is stagnant, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis.To control blood system, treat umbilicus interventral reality full, expectorant addiction, dispels and cuts off the water, by dyspepsia, broken blocked-up chest, relieving constipation is closed, non-this can not be also.If skin pruritus, because of hematocele stagnant in, can not nutrition flesh table, if diet is not thought, because spleen pent-up can not transporting, all get power that its pungent loose hardship rushes down also.For the gas medicine in blood system, only this claims.

Radix Puerariae: sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Chinese medicine short treating period of the present invention, instant effect, can restrain granulation promoting, anti-inflammatory analgetic, reparation mucosa, can treating both the principal and secondary aspects of a disease, not easily recur, and cost is lower, seance, and lifetime immunity power strengthens, easy to use, suitablely promotes the use of.

Collect 120 routine oral ulcer patients, man 60 example, female 60 example; Age 15-65 year, average 35 years old; Be divided into matched group (subsides Amlexanox oral patch) and experimental group at random, often organize 60 examples; Each group of patient age symptom is formed without significant difference;

Statistical result is as follows:

	Cure	Effectively	Invalid	Effective percentage
					Experimental group	58	1	1	98.33％
Matched group	10	15	35	41.67％

Efficacy evaluation:

Cure: after treatment, symptom all disappears;

Effective: after treatment, symptom is obviously improved;

Invalid: after treatment, symptom is not improved.

Result: in experimental group, in 60 routine patients, cure rate is 96.67%; The cure rate of matched group is 16.67%, to sum up, the cure rate of experimental group and effective percentage far away higher than matched group, so the treatment of buccal tablet of the present invention to oral ulcer has good curative effect, can promote the use of.

Below enumerate several model case:

Case 1:

Liu so-and-so, man, 25 years old, operating pressure was comparatively large, works and rests irregular, oral ulcer not improvement in 1 week, after take buccal tablet of the present invention, rehabilitation after 3 days.

Case 2:

Grandson so-and-so, female, 27 years old, due to frequent fat-reducing, has a meal irregular, oral ulcer 2 weeks without improving, after take buccal tablet of the present invention, rehabilitation after 5 days.

Detailed description of the invention

Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to specific embodiment.

Embodiment 1:

A kind of buccal tablet for the treatment of oral ulcer; formulated by the raw material of Chinese medicine of following parts by weight: Calculus Bovis 4 parts, Borneolum Syntheticum 6 parts, 6 parts, Radix Glycyrrhizae, Alumen 6 parts, Fructus Chebulae 15 parts, Fructus Evodiae 12 parts, Rhizoma Arisaematis 6 parts, Radix Ginseng 6 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 10 parts, Cortex Phellodendri 12 parts, Herba Asari 6 parts, Flos Lonicerae 6 parts, Fructus Forsythiae 15 parts, Herba Pogostemonis 12 parts, the Radix Aucklandiae 10 parts, Herba Eupatorii 10 parts, 15 parts, Poria, Massa Medicata Fermentata 12 parts, Fructus Aurantii Immaturus 6 parts, Radix Puerariae 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts.

Embodiment 2:

A kind of buccal tablet for the treatment of oral ulcer; formulated by the raw material of Chinese medicine of following parts by weight: Calculus Bovis 6 parts, Borneolum Syntheticum 4 parts, 8 parts, Radix Glycyrrhizae, Alumen 4 parts, Fructus Chebulae 20 parts, Fructus Evodiae 10 parts, Rhizoma Arisaematis 8 parts, Radix Ginseng 4 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 12 parts, Cortex Phellodendri 10 parts, Herba Asari 8 parts, Flos Lonicerae 4 parts, Fructus Forsythiae 20 parts, Herba Pogostemonis 10 parts, the Radix Aucklandiae 12 parts, Herba Eupatorii 8 parts, 20 parts, Poria, Massa Medicata Fermentata 10 parts, Fructus Aurantii Immaturus 8 parts, Radix Puerariae 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts.

Embodiment 3:

Treat a buccal tablet for oral ulcer, formulated by the raw material of Chinese medicine of following parts by weight: Calculus Bovis 5 parts, Borneolum Syntheticum 5 parts, 7 parts, Radix Glycyrrhizae; Alumen 5 parts, Fructus Chebulae 18 parts, Fructus Evodiae 11 parts, Rhizoma Arisaematis 7 parts; Cortex Phellodendri 11 parts, Radix Ginseng 5 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 11 parts, Herba Asari 7 parts; yellow 5 parts of gold silver, Fructus Forsythiae 18 parts, Herba Pogostemonis 11 parts, the Radix Aucklandiae 11 parts; Herba Eupatorii 9 parts, 18 parts, Poria, Massa Medicata Fermentata 11 parts; Fructus Aurantii Immaturus 7 parts, Radix Puerariae 18 parts, the Rhizoma Atractylodis Macrocephalae 11 parts.

Embodiment 4:

A kind of preparation method for the treatment of the buccal tablet of oral ulcer, step is as follows: other raw materials except Radix Ginseng and RHIIZOMA DIOSCOREAE fr0m Henan of China of the raw material in embodiment 1 are put into alembic, with its effective ingredient of extraction by steam distillation, after Radix Ginseng and Chinese yam powder are broken into fine powder, mix with cane sugar powder and put into extracting solution, stir and make soft material, cross 10 mesh sieves and obtain granule, after granule is added magnesium, put into tabletting machine, obtain the tablet of every sheet 0.18g.

Using method, each a slice, every day 3 times.

Embodiment 5:

A kind of preparation method for the treatment of the buccal tablet of oral ulcer, step is as follows: other raw materials except Radix Ginseng and RHIIZOMA DIOSCOREAE fr0m Henan of China of the raw material in embodiment 2 are put into alembic, with its effective ingredient of extraction by steam distillation, after Radix Ginseng and Chinese yam powder are broken into fine powder, mix with cane sugar powder and put into extracting solution, stir and make soft material, cross 20 mesh sieves and obtain granule, after granule is added magnesium, put into tabletting machine, obtain the tablet of every sheet 0.15g.

Using method, each a slice, every day 5 times.

Embodiment 6:

A kind of preparation method for the treatment of the buccal tablet of oral ulcer, step is as follows: other raw materials except Radix Ginseng and RHIIZOMA DIOSCOREAE fr0m Henan of China of the raw material in embodiment 3 are put into alembic, with its effective ingredient of extraction by steam distillation, after Radix Ginseng and Chinese yam powder are broken into fine powder, mix with cane sugar powder and put into extracting solution, stir and make soft material, cross 15 mesh sieves and obtain granule, after granule is added magnesium, put into tabletting machine, obtain the tablet of every sheet 0.16g.

Using method, each a slice, every day 4 times.

Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.

Claims (3)

1. treat the buccal tablet of oral ulcer for one kind; it is characterized in that according to weight parts; prepared by following raw material of Chinese medicine: Calculus Bovis 4-6 part, Borneolum Syntheticum 4-6 part, Radix Glycyrrhizae 6-8 part, Alumen 4-6 part, Fructus Chebulae 15-20 part, Fructus Evodiae 10-12 part, Rhizoma Arisaematis 6-8 part, Radix Ginseng 4-6 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 10-12 part, Cortex Phellodendri 10-12 part, Herba Asari 6-8 part, Flos Lonicerae 4-6 part, Fructus Forsythiae 15-20 part, Herba Pogostemonis 10-12 part, Radix Aucklandiae 10-12 part, Herba Eupatorii 8-10 part, Poria 15-20 part, Massa Medicata Fermentata 10-12 part, Fructus Aurantii 6-8 part, Radix Puerariae 15-20 part, Rhizoma Atractylodis Macrocephalae 10-12 part.

2. a kind of buccal tablet for the treatment of oral ulcer according to claim 1, is characterized in that according to weight parts, formulated by following raw material of Chinese medicine: Calculus Bovis 5 parts, Borneolum Syntheticum 5 parts; 7 parts, Radix Glycyrrhizae, Alumen 5 parts, Fructus Chebulae 18 parts, Fructus Evodiae 11 parts; Rhizoma Arisaematis 7 parts, Cortex Phellodendri 11 parts, Radix Ginseng 5 parts, RHIIZOMA DIOSCOREAE fr0m Henan of China 11 parts; Herba Asari 7 parts, yellow 5 parts of gold silver, Fructus Forsythiae 18 parts, Herba Pogostemonis 11 parts; the Radix Aucklandiae 11 parts, Herba Eupatorii 9 parts, 18 parts, Poria, Massa Medicata Fermentata 11 parts; Fructus Aurantii 7 parts, Radix Puerariae 18 parts, the Rhizoma Atractylodis Macrocephalae 11 parts.

3. the preparation method of the buccal tablet of a treatment oral ulcer according to claim 1, it is characterized in that step is as follows: other raw materials except Radix Ginseng and RHIIZOMA DIOSCOREAE fr0m Henan of China are put into alembic, with its effective ingredient of extraction by steam distillation, after Radix Ginseng and Chinese yam powder are broken into fine powder, mix with cane sugar powder and put into extracting solution, stir and make soft material, cross 10-20 mesh sieve and obtain granule, after granule is added magnesium, put into tabletting machine, obtain the tablet of every sheet 0.15-0.18g.