CN106036862A - Fructus aurantii immaturus buccal tablets - Google Patents
Fructus aurantii immaturus buccal tablets Download PDFInfo
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- CN106036862A CN106036862A CN201610453357.4A CN201610453357A CN106036862A CN 106036862 A CN106036862 A CN 106036862A CN 201610453357 A CN201610453357 A CN 201610453357A CN 106036862 A CN106036862 A CN 106036862A
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- 239000010135 fructus aurantii immaturus Substances 0.000 title claims abstract description 48
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 27
- 210000000582 semen Anatomy 0.000 claims abstract description 24
- 239000004365 Protease Substances 0.000 claims abstract description 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 18
- 108091005804 Peptidases Proteins 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 16
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 14
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 14
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims abstract description 9
- 239000000853 adhesive Substances 0.000 claims abstract description 9
- 230000001070 adhesive effect Effects 0.000 claims abstract description 9
- 239000000314 lubricant Substances 0.000 claims abstract description 9
- 240000008790 Musa x paradisiaca Species 0.000 claims abstract description 8
- 244000269722 Thea sinensis Species 0.000 claims abstract description 6
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004006 olive oil Substances 0.000 claims abstract description 6
- 235000008390 olive oil Nutrition 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 235000010447 xylitol Nutrition 0.000 claims abstract description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 6
- 229960002675 xylitol Drugs 0.000 claims abstract description 6
- 239000000811 xylitol Substances 0.000 claims abstract description 6
- 244000182264 Lucuma nervosa Species 0.000 claims abstract description 4
- 235000000564 Lucuma nervosa Nutrition 0.000 claims abstract description 4
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract 2
- 229940013618 stevioside Drugs 0.000 claims abstract 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000019202 steviosides Nutrition 0.000 claims abstract 2
- 229940046011 buccal tablet Drugs 0.000 claims description 23
- 235000019419 proteases Nutrition 0.000 claims description 15
- 235000009392 Vitis Nutrition 0.000 claims description 12
- 241000219095 Vitis Species 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- 102000002322 Egg Proteins Human genes 0.000 claims description 8
- 108010000912 Egg Proteins Proteins 0.000 claims description 8
- 235000013345 egg yolk Nutrition 0.000 claims description 8
- 210000002969 egg yolk Anatomy 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 108091005658 Basic proteases Proteins 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 108090000526 Papain Proteins 0.000 claims description 4
- 229940088598 enzyme Drugs 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229940055729 papain Drugs 0.000 claims description 4
- 235000019834 papain Nutrition 0.000 claims description 4
- 244000144725 Amygdalus communis Species 0.000 claims description 3
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 3
- 108090000145 Bacillolysin Proteins 0.000 claims description 3
- 101710132601 Capsid protein Proteins 0.000 claims description 3
- 108091005507 Neutral proteases Proteins 0.000 claims description 3
- 102000035092 Neutral proteases Human genes 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims description 3
- 235000007164 Oryza sativa Nutrition 0.000 claims description 3
- 244000202052 Poncirus trifoliata Species 0.000 claims description 3
- 235000000404 Poncirus trifoliata Nutrition 0.000 claims description 3
- 235000020224 almond Nutrition 0.000 claims description 3
- 238000000748 compression moulding Methods 0.000 claims description 3
- 230000007159 enucleation Effects 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 238000001728 nano-filtration Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000003531 protein hydrolysate Substances 0.000 claims description 3
- 235000009566 rice Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 3
- 230000032683 aging Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000796 flavoring agent Substances 0.000 abstract description 2
- 235000019634 flavors Nutrition 0.000 abstract description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 abstract 1
- 235000012333 Vitis X labruscana Nutrition 0.000 abstract 1
- 240000006365 Vitis vinifera Species 0.000 abstract 1
- 235000014787 Vitis vinifera Nutrition 0.000 abstract 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 abstract 1
- 229940107187 fructooligosaccharide Drugs 0.000 abstract 1
- 229940109850 royal jelly Drugs 0.000 abstract 1
- 229920001202 Inulin Polymers 0.000 description 4
- -1 Inulin glycosides Chemical class 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 229930182470 glycoside Natural products 0.000 description 4
- 229940029339 inulin Drugs 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000234295 Musa Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
The invention provides fructus aurantii immaturus buccal tablets. The fructus aurantii immaturus buccal tablets are prepared from the following raw materials in parts by weight: 55 to 60 parts of fructus aurantii immaturus, 45 to 55 parts of semen armeniacae amarae, 10 to 13 parts of banana, 3 to 6 parts of grape seeds, 2 to 5 parts of eggfruit peel, 1 to 1.2 parts of mixed protease, 2 to 3 parts of xylitol, 1.2 to 1.8 parts of fructo-oligosaccharide, 0.6 to 0.8 part of stevioside, 0.2 to 0.4 part of olive oil, 0.3 to 0.6 part of tea polysaccharide, 0.3 to 0.5 part of citric acid, 0.2 to 0.3 part of royal jelly, 0.5 to 0.8 part of adhesive and 0.6 to 1.0 part of lubricant. Fructus aurantii immaturus protein in the fructus aurantii immaturus buccal tablets has the effects of reducing blood fat, reducing blood press, increasing the immunity, resisting aging and the like, can be easily absorbed and utilized; the taste is better, the flavor is unique, the eating is convenient, the health requirements of people are well met, and the suitable crowd is wide.
Description
Technical field
The invention belongs to Fructus Aurantii Immaturus manufacture field, relate to a kind of Fructus Aurantii Immaturus buccal tablet.
Background technology
Buccal tablet is often with edible, easy to carry and favored by people.And existing functional plants buccal tablet processing and fabricating side
It, because the most first extracting the effective ingredient in plant, by filtering, being concentrated to give extractum, then is mixed pressure by method with filler
Sheet.Obviously, these methods not only complex process, production efficiency is low, requires the highest to equipment and processing conditions, and difficult
Effectively to keep material nutrient component.On the other hand, raw material is after extraction is filtered, and major part insoluble component is dropped, and these
Insoluble component also contains the effective ingredient having economic worth in a large number, and the utilization rate thus resulting in raw material value is the lowest, causes money
Source is wasted, the most uneconomical, hinders the development in buccal tablet market.
Summary of the invention
Instant invention overcomes above-mentioned deficiency, it is provided that a kind of there is blood sugar lowering, improve the health care such as immunity
Fructus Aurantii Immaturus buccal tablet and preparation method thereof.
A kind of Fructus Aurantii Immaturus buccal tablet, is made up of the raw material of following weight portion: Fructus Aurantii Immaturus 55-60 part, Semen Armeniacae Amarum 45-55 part, Fructus Musae 10-13 part,
Semen Vitis viniferae 3-6 part, egg yolk peel 2-5 part, mixing protease 1-1.2 part, xylitol 2-3 part, oligofructose 1.2-1.8 part, sweet
Inulin glycosides 0.6-0.8 part, olive oil 0.2-0.4 part, tea polysaccharide 0.3-0.6 part, citric acid 0.3-0.5 part, Lac regis apis 0.2-0.3
Part, adhesive 0.5-0.8 part, lubricant 0.6-1.0 part.
Described mixing protease is made up of the protease of following weight portion: alkaline protease 0.7 part, neutral protease
00.8 part and papain 1.2 parts.
The preparation method of described Fructus Aurantii Immaturus buccal tablet, it is characterised in that specifically include following step:
(1) preparation of Fructus Aurantii Immaturus protein dry powder:
A, take Fructus Aurantii Immaturus, Semen Armeniacae Amarum, 50-58 DEG C of cold drying, pulverize, cross 120-130 mesh sieve and go the removal of impurity, add water to liquid level and exceed thing
Material 1-2cm, stirs evenly, 86-88 DEG C of water-bath, the ultrasonic 30-40min of 28-30KHz, constant temperature alkali leach protein, isoelectric precipitation, with
8000r/min is centrifuged 8min, removes supernatant, neutralizes, is dried to without moisture, obtains Fructus Aurantii Immaturus Semen Armeniacae Amarum separation albumen；
B, by Fructus Aurantii Immaturus dregs of rice core separation albumen add mixing protease, after 48 DEG C of constant temperature enzymolysis, 100 DEG C of water-bath enzyme denaturing 12-15s, with
8000r/min is centrifuged 8min, takes supernatant, obtains Fructus Aurantii Immaturus almond protein hydrolyzed solution；
C, it is the nanofiltration membrane of 2-3nm by Fructus Aurantii Immaturus core protein hydrolyzate aperture, then carries out lyophilization, obtain high-purity trifoliate orange
Real protein dry powder；
(2) Fructus Musae cleaned, remove the peel, section, thickness is 0.3-0.5cm, soaks, cold drying, then by dried banana chip
Carrying out micronizing, being crushed to particle diameter is 22-24 μm, obtains banana starch；
(3) Semen Vitis viniferae, egg yolk peel are cleaned enucleation, dry, pulverize, cross 150-160 mesh sieve, add Semen Vitis viniferae and eggfruit
The water of skin gross weight 2-3 times, 86-88 DEG C of water-bath, the ultrasonic 30-40min of 28-30KHz, it is centrifuged 8min with 10000r/min, takes
Clear liquid, is spray-dried, and obtains xeraphium；
(4) gained raw material is mixed with other raw materials, add adhesive, High Shear Mixer Granulator, be dried, add in dry granule
Enter lubricant, mix homogeneously, compression molding, obtain Fructus Aurantii Immaturus buccal tablet.
The pH that alkali in described step a carries is 8-8.9, and Extracting temperature is 45-55 DEG C, and extraction time is 40-48min.
The invention has the beneficial effects as follows: the Fructus Aurantii Immaturus albumen in this buccal tablet has blood fat reducing, blood pressure lowering, raising immunity, resists
The effects such as aging, Fructus Aurantii Immaturus protein ingredient is through specific proteases directionally hydrolyzing, can preferably be absorbed by the body；Buccal tablet with the addition of
Banana starch composition, substitutes traditional starch as forming agent, it is possible to decrease product heat, strengthens it and prevents and treats intestinal tract disease, reduces blood
The physiological functions such as sugar, raising immunity, are suitable for diabetes patient, and the applicable crowd of product is more extensive；Green banana resistance is formed sediment
Powder raw material is through micronizing, and due to the micronization of granule, its surface area and porosity dramatically increase, the dispersibility of product,
Dissolubility, functional available significantly improvement, it is easier to be absorbed by the body utilization, and mouthfeel is more preferable, with the addition of Semen Vitis viniferae, egg
Pericarpium Citri junoris so that buccal tablet has raising immunity, anti-ageing effect of waiting for a long time, the buccal tablet delicate mouthfeel of the present invention, unique flavor, eats
Convenient, take safety, preferably meet the health requirements of people, be suitable for crowd extensive.
Detailed description of the invention
Below the preferably embodiment of the present invention is described in further detail.
Embodiment 1
A kind of Fructus Aurantii Immaturus buccal tablet, is made up of the raw material of following weight portion: Fructus Aurantii Immaturus 55-60 part, Semen Armeniacae Amarum 45-55 part, Fructus Musae 10-13 part,
Semen Vitis viniferae 3-6 part, egg yolk peel 2-5 part, mixing protease 1-1.2 part, xylitol 2-3 part, oligofructose 1.2-1.8 part, sweet
Inulin glycosides 0.6-0.8 part, olive oil 0.2-0.4 part, tea polysaccharide 0.3-0.6 part, citric acid 0.3-0.5 part, Lac regis apis 0.2-0.3
Part, adhesive 0.5-0.8 part, lubricant 0.6-1.0 part.
Described mixing protease is made up of the protease of following weight portion: alkaline protease 0.7 part, neutral protease
00.8 part and papain 1.2 parts.
The preparation method of described Fructus Aurantii Immaturus buccal tablet, it is characterised in that specifically include following step:
(1) preparation of Fructus Aurantii Immaturus protein dry powder:
A, take Fructus Aurantii Immaturus, Semen Armeniacae Amarum, 50-58 DEG C of cold drying, pulverize, cross 120-130 mesh sieve and go the removal of impurity, add water to liquid level and exceed thing
Material 1-2cm, stirs evenly, 86-88 DEG C of water-bath, the ultrasonic 30-40min of 28-30KHz, constant temperature alkali leach protein, isoelectric precipitation, with
8000r/min is centrifuged 8min, removes supernatant, neutralizes, is dried to without moisture, obtains Fructus Aurantii Immaturus Semen Armeniacae Amarum separation albumen；
B, by Fructus Aurantii Immaturus dregs of rice core separation albumen add mixing protease, after 48 DEG C of constant temperature enzymolysis, 100 DEG C of water-bath enzyme denaturing 12-15s, with
8000r/min is centrifuged 8min, takes supernatant, obtains Fructus Aurantii Immaturus almond protein hydrolyzed solution；
C, it is the nanofiltration membrane of 2-3nm by Fructus Aurantii Immaturus core protein hydrolyzate aperture, then carries out lyophilization, obtain high-purity trifoliate orange
Real protein dry powder；
(2) Fructus Musae cleaned, remove the peel, section, thickness is 0.3-0.5cm, soaks, cold drying, then by dried banana chip
Carrying out micronizing, being crushed to particle diameter is 22-24 μm, obtains banana starch；
(3) Semen Vitis viniferae, egg yolk peel are cleaned enucleation, dry, pulverize, cross 150-160 mesh sieve, add Semen Vitis viniferae and eggfruit
The water of skin gross weight 2-3 times, 86-88 DEG C of water-bath, the ultrasonic 30-40min of 28-30KHz, it is centrifuged 8min with 10000r/min, takes
Clear liquid, is spray-dried, and obtains xeraphium；
(4) gained raw material is mixed with other raw materials, add adhesive, High Shear Mixer Granulator, be dried, add in dry granule
Enter lubricant, mix homogeneously, compression molding, obtain Fructus Aurantii Immaturus buccal tablet.
The pH that alkali in described step a carries is 8-8.9, and Extracting temperature is 45-55 DEG C, and extraction time is 40-48min.
Mixing protease in described step b is made up of the protease of following weight portion: alkaline protease 0.7 part, neutrality
Proteinase-10 0.8 part and papain 1.2 parts.
Embodiment 2
Embodiment 2 difference from Example 1 is that the parts by weight of raw material in Fructus Aurantii Immaturus buccal tablet are different, and other conditions are the most identical.
A kind of Fructus Aurantii Immaturus buccal tablet, is made up of the raw material of following weight portion: Fructus Aurantii Immaturus 55-60 part, Semen Armeniacae Amarum 45-55 part, Fructus Musae 10-13 part,
Semen Vitis viniferae 3-6 part, egg yolk peel 2-5 part, mixing protease 1-1.2 part, xylitol 2-3 part, oligofructose 1.2-1.8 part, sweet
Inulin glycosides 0.6-0.8 part, olive oil 0.2-0.4 part, tea polysaccharide 0.3-0.6 part, citric acid 0.3-0.5 part, Lac regis apis 0.2-0.3
Part, adhesive 0.5-0.8 part, lubricant 0.6-1.0 part.
Embodiment 3
Embodiment 3 difference from Example 1 is that the parts by weight of raw material in Fructus Aurantii Immaturus buccal tablet are different, and other conditions are the most identical.
A kind of Fructus Aurantii Immaturus buccal tablet, is made up of the raw material of following weight portion: Fructus Aurantii Immaturus 55-60 part, Semen Armeniacae Amarum 45-55 part, Fructus Musae 10-13 part,
Semen Vitis viniferae 3-6 part, egg yolk peel 2-5 part, mixing protease 1-1.2 part, xylitol 2-3 part, oligofructose 1.2-1.8 part, sweet
Inulin glycosides 0.6-0.8 part, olive oil 0.2-0.4 part, tea polysaccharide 0.3-0.6 part, citric acid 0.3-0.5 part, Lac regis apis 0.2-0.3
Part, adhesive 0.5-0.8 part, lubricant 0.6-1.0 part.
Claims (4)
1. a Fructus Aurantii Immaturus buccal tablet, it is characterised in that be made up of the raw material of following weight portion: Fructus Aurantii Immaturus 55-60 part, Semen Armeniacae Amarum 45-55 part,
Fructus Musae 10-13 part, Semen Vitis viniferae 3-6 part, egg yolk peel 2-5 part, mixing protease 1-1.2 part, xylitol 2-3 part, oligofructose
1.2-1.8 part, stevioside 0.6-0.8 part, olive oil 0.2-0.4 part, tea polysaccharide 0.3-0.6 part, citric acid 0.3-0.5 part,
Lac regis apis 0.2-0.3 part, adhesive 0.5-0.8 part, lubricant 0.6-1.0 part.
2. preparation method as claimed in claim 2, it is characterised in that described mixing protease is by the albumen of following weight portion
Enzyme forms: alkaline protease 0.7 part, neutral protease 00.8 part and papain 1.2 parts.
3. the preparation method of Fructus Aurantii Immaturus buccal tablet as claimed in claim 1, it is characterised in that specifically include following step:
(1) preparation of Fructus Aurantii Immaturus protein dry powder:
A, take Fructus Aurantii Immaturus, Semen Armeniacae Amarum, 50-58 DEG C of cold drying, pulverize, cross 120-130 mesh sieve and go the removal of impurity, add water to liquid level and exceed thing
Material 1-2cm, stirs evenly, 86-88 DEG C of water-bath, the ultrasonic 35-40min of 28-30KHz, constant temperature alkali leach protein, isoelectric precipitation, with
8000r/min is centrifuged 8min, removes supernatant, neutralizes, is dried to without moisture, obtains Fructus Aurantii Immaturus Semen Armeniacae Amarum separation albumen；
B, by Fructus Aurantii Immaturus dregs of rice core separation albumen add mixing protease, after 48 DEG C of constant temperature enzymolysis, 100 DEG C of water-bath enzyme denaturing 12-15s, with
8000r/min is centrifuged 8min, takes supernatant, obtains Fructus Aurantii Immaturus almond protein hydrolyzed solution；
C, it is the nanofiltration membrane of 2-3nm by Fructus Aurantii Immaturus core protein hydrolyzate aperture, then carries out lyophilization, obtain high-purity trifoliate orange
Real protein dry powder；
(2) Fructus Musae cleaned, remove the peel, section, thickness is 0.3-0.5cm, soaks, cold drying, then by dried banana chip
Carrying out micronizing, being crushed to particle diameter is 22-24 μm, obtains banana starch；
(3) Semen Vitis viniferae, egg yolk peel are cleaned enucleation, dry, pulverize, cross 150-160 mesh sieve, add Semen Vitis viniferae and eggfruit
The water of skin gross weight 2-3 times, 78-88 DEG C of water-bath, the ultrasonic 38-40min of 30-33KHz, it is centrifuged 8min with 10000r/min, takes
Clear liquid, is spray-dried, and obtains xeraphium；
(4) gained raw material is mixed with other raw materials, add adhesive, High Shear Mixer Granulator, be dried, add in dry granule
Enter lubricant, mix homogeneously, compression molding, obtain Fructus Aurantii Immaturus buccal tablet.
4. preparation method as claimed in claim 2, it is characterised in that the pH that the alkali in described step a carries is 8-8.9, extracts
Temperature is 45-55 DEG C, and extraction time is 40-48min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610453357.4A CN106036862A (en) | 2016-06-22 | 2016-06-22 | Fructus aurantii immaturus buccal tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610453357.4A CN106036862A (en) | 2016-06-22 | 2016-06-22 | Fructus aurantii immaturus buccal tablets |
Publications (1)
| Publication Number | Publication Date |
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| CN106036862A true CN106036862A (en) | 2016-10-26 |
Family
ID=57168787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610453357.4A Pending CN106036862A (en) | 2016-06-22 | 2016-06-22 | Fructus aurantii immaturus buccal tablets |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147375A (en) * | 2014-08-29 | 2014-11-19 | 蔡炜 | Buccal tablet for treating gum bleeding |
| CN104274763A (en) * | 2014-10-27 | 2015-01-14 | 山东大学齐鲁医院 | Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation |
| CN104473171A (en) * | 2014-12-31 | 2015-04-01 | 广西壮族自治区农业科学院农产品加工研究所 | Cannabis sativa buccal tablet and preparation method thereof |
| CN104587138A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Buccal tablets for treating mouth ulcer and preparation method thereof |
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2016
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|---|---|---|---|---|
| CN104147375A (en) * | 2014-08-29 | 2014-11-19 | 蔡炜 | Buccal tablet for treating gum bleeding |
| CN104274763A (en) * | 2014-10-27 | 2015-01-14 | 山东大学齐鲁医院 | Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation |
| CN104473171A (en) * | 2014-12-31 | 2015-04-01 | 广西壮族自治区农业科学院农产品加工研究所 | Cannabis sativa buccal tablet and preparation method thereof |
| CN104587138A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Buccal tablets for treating mouth ulcer and preparation method thereof |
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| Title |
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Application publication date: 20161026 |