CN104274763A - Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation - Google Patents

Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation Download PDF

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Publication number
CN104274763A
CN104274763A CN201410583368.5A CN201410583368A CN104274763A CN 104274763 A CN104274763 A CN 104274763A CN 201410583368 A CN201410583368 A CN 201410583368A CN 104274763 A CN104274763 A CN 104274763A
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weight portion
herba
chinese medicine
mastic
medicine preparation
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陈安威
刘少华
万凤丽
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Qilu Hospital of Shandong University
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Qilu Hospital of Shandong University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
    • A—HUMAN NECESSITIES
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection. The traditional Chinese medicine preparation comprises honeysuckle, fructus forsythiae, folium isatidis, mother chrysanthemum, wild buckwheat, semen oroxyli, the root of Chinese pulsatilla, purslane, edible tulip, yellowweed, radix ampelopsis, calculus bovis, eupatorium, mangnolia officinalis, amomum kravanh, immature bitter orange, fevervine, Poria cocos, semen coicis, caulis clematidis armandii, junci medulla, rattletop, gypsum rubrum, bamboo leaf, endive, bark of Indian quassiawood, fimbriate calanthe pseudobulb, dindygulen peperomia herb, Roughhaired Holly Root, natant salvinia herb, pterocephalus hookeri heck, manystem stonecrop leaf and phaenosperma globosa. The traditional Chinese medicine preparation has the effects of clearing away heat and toxic materials and invigorating spleen to eliminate dampness and is mainly used for treating toxin syndromes of recurrent oral ulcer during external infection. By utilizing the theory of traditional Chinese medicine, the overall immunity of the organism is regulated on the basis of the overall concept, the targeting property is high during treatment based on syndrome differentiation, the traditional Chinese medicine preparation has the effects of diminishing inflammation and relieving pain, expansion of the wound surface is avoided, and the drug effect is directly accessed to the lesions. Moreover, the traditional Chinese medicine preparation is safe and effective and difficultly generates drug resistance, and the reoccurrence rate is reduced.

Description

Chinese medicine preparation for the treatment of diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration and preparation method thereof
 
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly treating Chinese medicine preparation of diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration and preparation method thereof.
 
Background technology
Recurrent oral ulceration is also called recurrent aphtha or recurrent aphthous stomatitis, and be modal diseases of oral mucosa, its prevalence occupies first of diseases of oral mucosa, has at least 1 people that oral ulcer occurred in every 5 people of various countries' Epidemiological study display.This disease is with the ulcer of oral mucosa each position recurrent exerbation for feature, and without other diseases sign, have periodicity, recurrent, self limiting feature, ulcer causalgia is obvious.Be apt to occur in the position of the keratinization differences such as lip, tongue, cheek, soft palate.
The pathology cause of disease: the cause of disease is complicated, there is obvious individual variation.The pathogenic factors of research report is a lot of, but there is no unified definite saying.It may be the synthesis result of many factors.1. immune factor (1) cellular immune abnormality: cellular immunization mainly refers to the immune response of T cell mediated.Cellular immunization participates in primarily of the T cell subclass that two classes are different, and a class is cytotoxic T cell (CTL), and another kind of is the super quick T cell (TDTH) of delayed.(2) humoral immunization exception and autoimmune: humoral immunization is that the specific immune globulin produced by bone-marrow-derived lymphocyte is realized.Autoimmune is that antibody is to a kind of responsing reaction from the antigen of self.(3) immunologic hypofunction and immunodeficiency: someone confirms that the reaction of the lymphocyte of RAU patient to PHA and canavaline (ConA) is all low than normal person in each stage of ulcer.When making antigenic stimulus body by thymus virus, the irritant reaction of RAU patient also belongs to low.The RAU conditions of patients of HIV is often heavier.Illustrate that RAU may be relevant with immunologic hypofunction or immunodeficiency.2. inherited genetic factors: show the research of the monogenic inheritance of RAU, polygenic inheritance, genetic marker and hereditary material, the morbidity of PAU has genetic predisposition.3. systemic disease factor: clinical practice experience and Epidemiological study find RAU and gastric ulcer, duodenal ulcer, ulcerative colitis, regional enteritis.
Symptom and sign: primary disease typing is a lot of, can, ulcer depth typing how many according to form size, ulcer, there is no unified typing.From clinical practice viewpoint, recurrent oral ulceration is divided 3 types, Lehner (1968) classifying method that many employings are universally acknowledged, be namely divided into light-duty, heavy and stomatitis herpetiformis.1. light-duty aphtha is the most common.Account for 80% of RAU.Ulcer is little, general diameter 2 ~ 4mm.Round or oval, circumference is clear, isolates and is dispersed in, and number is few, shows effect 1 ~ 5 at every turn.Be apt to occur in the region that keratinization degree is poor, as lip, cheek mucosa.The less generation of the gum that keratinization degree is high, palatine.During outbreak, ulcer has " recessed, red, yellow, bitterly " feature.I.e. ulcer concavity, substrate is not hard, and periphery is with the congested blush band of about 1mm, and surface is covered with light yellow pseudomembrane, and causalgia sense is obvious.MiAU recurrence is regular, is generally divided into stage of attack, healing stage and intermission.Stage of attack, is subdivided into again prodromal period and ulcerative stage.There is mucosa local discomfort prodromal period, touch a tender spot or causalgia sense; White or red papules shape point is there is after about 24h; Epithelium posterius breakage in 2 ~ 3 days.Enter ulcerative stage; After 4 ~ 5 days, blush disappears again, and ulcer healing, does not stay cicatrix.Whole stage of attack, generally continues 1 ~ 2 week, has the self limiting of recovery occurs without treatment.Intermission is different in size.Vary with each individual.But the general onset intermission is longer, after this shortens gradually.Without stop until rise one after another.MiAU affects language, feed, mood because stimulating pain, thus has a negative impact to quality of life.2. herpes sample aphtha is also known as aphthous stomatitis.Ulcer is little and many, and be dispersed in and be distributed in any position of mucosa, diameter is less than 2mm, can reach more than dozens of, seemingly has " Caulis et folium pavettae hongkongensis " to feel.Contiguous ulcer can merge in flakes, and mucosa hyperemia is rubescent, and pain comparatively MiAU is heavy.Salivation increases, can the symptom such as companioned with headache, low grade fever, general malaise, regional glandular enlargement.The same MiAU of rule of onset, does not stay cicatrix.3. heavy aphtha, also known as Periadenitis mucosa periadenitis, periglandular aphthae ulcer 1 ~ 2, dark greatly, diameter can reach 1 ~ 3cm, deeply can reach Submucosa and even reach muscle layer, ulcer surrounding tissue is red and swollen, and edge is protuberance slightly, and palpation is harder, ulcer has canescence pseudomembrane to cover, touch a tender spot obviously, through the healing of 1 to several months, leave clear scar more afterwards.Occur in soft palate, soft or hard palate intersection, palate hang down or soft palate and pharynx are other locates, visible cicatrix, in vain, in contracture shape, or palate hangs down defect and being out of shape color.As occurred in buccal bicker place, because of cicatricial contracture, limitation of mouth opening.Although major aphtha ulcer is large and dark, healing time is very long, spontaneous pain, excites pain comparatively violent, general without General Symptoms.
Chinese medicine is thought, recurrent oral ulceration belongs to the traditional Chinese medical science " aphtha ", " mouth infections " category.The name of " aphtha " is first appeared in "Nei Jing".Say in " the large opinion of Plain Questions gas alternation ": " year gold too late, scorching fire is up ... the sick aphtha of the people, very then pained." point out that aphtha is with intimately for basic pathogenic factors first.Later age doctor on this basis, to its understanding gradually deeply.As " danxi's experiential therapy ability to speak " section is said: " aphtha takes medicine of a cold nature unhealed, because of in scorched earth empty, and can not eat, fire rushes to without system mutually ", point out that deficiency-weakness of spleen-QI and aphtha have close ties." Shengji Zonglu " is thought, and " aphtha person, has the Hot-air blowing device part of the body cavity above the diaphragm housing the heart and lungs by heart spleen, a smoked dispute, and is aphtha." indicate aphtha and the dirty relation of heart spleen two.Clear grasping together intelligently to propose further " aphtha part of the body cavity above the diaphragm housing the heart and lungs excess-heat, deficiency-cold in middle-JIAO, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-fire; respectively caused by the change of disease, control it when resolution negative and positive deficiency and excess cold and heat " in " Qi Shi case aphtha ", thinks that part of the body cavity above the diaphragm housing the heart and lungs excess-fire is fumigated, scorching in part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-fire, deficiency-cold in middle-JIAO or stagnation of dampness due to deficiency of the spleen are the pathogenesis of primary disease.
Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs: 1, diseases caused by exogenous pathogenic factor seasonal noxious pathogen: aphtha to be mainly in after diseases caused by exogenous pathogenic factor 1 ~ 2 day, with diseases caused by exogenous pathogenic factor symptom.From the beginning of oral mucosa contrafluxion, redness, there is chestnut grain sample small red dot or exanthema vesiculosum in the tip of the tongue or lip, herpes diabrosis in 12 hours in hypodynia, in table fester, and clear border.2. heart spleen intrinsic heat: disease sees the raw skin ulcer of dispute many places erosion, and it is swollen that skin ulcer is flushing, and scorching hot pain, very then halitosis gingival swelling and pain, accompany thirsty polydipsia, yellowish urine constipation, red tongue with yellow fur, slippery and rapid pulse.3. deficiency of spleen-YANG and kidneyYANG: disease sees aphtha of the mouth and tongue, ulcer pale complexion, not red around, quantity is few, obstinate, and companion's extremity are not warm, and xerostomia desire for hot drinks, aching pain in waist and back, frequent micturition is long clearly, large loose stool, and pale tongue with white fur is greasy, deep and weak pulse.4. weakness of the spleen and stomach: disease sees aphtha of the mouth and tongue recurrent exerbation, the light depression of skin ulcer complexion, companion's Mental fatigue is breathed hard, and anorexia, extremity are not warm, loose stool, pale tongue with white fur, thready and weak pulse.5. hyperactivity of deficient fire: disease sees that ulcer color is scarlet, and quantity is many, and shape differs, and differs in size, pain is heavy for light night in daytime, and companion's cardiopalmus is vexed, and insomnia and dreamful sleep is forgetful, vertigo and tinnitus, soreness of waist and knee joint, dry mouth and throat, oliguria with yellow urine, red tongue with thin fur, thready and rapid pulse.6. blood deficiency the moon loses: disease is seen that dispute is festered and is multiplely born in before and after menstruation, and companion's preceeded menorrhea amount is many, dysphoria with feverish sensation in the chest palms and soles, and xerostomia happiness drink, pale tongue with thin fur is white, thready and rapid pulse without strength.
Western medical treatment recurrent oral ulceration main purpose is antiinflammatory, pain relieving, promotes ulcer healing, and common drug is as oradol buccal tablet, lysozyme buccal tablet, levamisole etc.But western medical treatment recurrent oral ulceration poisonous side effect of medicine used is comparatively large, easily produces drug resistance, there is no specific medicament at present; The obvious person of pain can apply burn, the treatment means such as laser is traumatic larger; Relapse rate is higher, causes certain stress to patient, reduces the quality of life of patient.
Chinese medicine recurrent oral ulceration has unique advantage: utilize Traditional Chinese medical theory, the basis of organic conception regulates animal economy immunity, can antiallergic action, improves microcirculation; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs targeting is comparatively strong, can antiinflammatory, pain relieving, prevent wound surface expansion etc., drug effect is gone directly focus, safe and effective, not easily produces drug resistance, reduces relapse rate etc., can carry out clinical market popularization.
 
Summary of the invention
Technical problem to be solved by this invention is, provides one and has heat-clearing and toxic substances removing, invigorating the spleen for eliminating dampness effect, cures mainly the Chinese medicine preparation of recurrent oral ulceration diseases caused by exogenous pathogenic factor seasonal noxious pathogen card.The present invention utilizes Traditional Chinese medical theory, and the basis of organic conception regulates animal economy immunity, can antiallergic action, improves microcirculation; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs targeting is comparatively strong, can antiinflammatory, pain relieving, prevent wound surface expansion etc., drug effect is gone directly focus, safe and effective, not easily produces drug resistance, reduces relapse rate etc.
For solving the problems of the technologies described above; the invention provides a kind of Chinese medicine preparation for the treatment of recurrent oral ulceration diseases caused by exogenous pathogenic factor seasonal noxious pathogen card, described Chinese medicine preparation comprises following raw medicinal material: Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci, Rhizoma Cimicifugae, Mirabilitum crystallina, Folium Bambusae, Herba Sonchi Arvensis, suspension rod fiber crops, pseudobulbus Calanthes fimbriatae, Herba Peperomiae Dindygulensis, Radix Ilicis Asprellae, Herba salviniae natantis, Herba pterocephali, Herba Sedi Multicaulis and Herba Phaenospermatis globosae.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 15-30 weight portion, Fructus Forsythiae 10-28 weight portion, Folium Isatidis 10-18 weight portion, Flos Chrysanthemi Indici 14-32 weight portion, Rhizoma Fagopyri Dibotryis 10-20 weight portion, Semen Oroxyli 10-24 weight portion, Radix Pulsatillae 10-20 weight portion, Herba Portulacae 13-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion, Herba Senecionis Scandentis 13-27 weight portion, Radix Ampelopsis 13-26 weight portion, Calculus Bovis 10-24 weight portion, Herba Eupatorii 12-27 weight portion, Cortex Magnoliae Officinalis 10-20 weight portion, Fructus Amomi Rotundus 10-25 weight portion, Fructus Aurantii Immaturus 13-24 weight portion, fevervine 10-24 weight portion, Poria 10-20 weight portion, Semen Coicis 10-18 weight portion, Caulis Clematidis Armandii 12-24 weight portion, Medulla Junci 12-26 weight portion, Rhizoma Cimicifugae 10-20 weight portion, Mirabilitum crystallina 10-18 weight portion, Folium Bambusae 15-28 weight portion, Herba Sonchi Arvensis 14-29 weight portion, suspension rod fiber crops 3-8 weight portion, pseudobulbus Calanthes fimbriatae 4-7 weight portion, Herba Peperomiae Dindygulensis 10-20 weight portion, Radix Ilicis Asprellae 13-25 weight portion, Herba salviniae natantis 12-25 weight portion, Herba pterocephali 2-5 weight portion, Herba Sedi Multicaulis 10-20 weight portion and Herba Phaenospermatis globosae 12-23 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25-30 weight portion, Fructus Forsythiae 20-28 weight portion, Folium Isatidis 15-18 weight portion, Flos Chrysanthemi Indici 24-32 weight portion, Rhizoma Fagopyri Dibotryis 15-20 weight portion, Semen Oroxyli 15-24 weight portion, Radix Pulsatillae 15-20 weight portion, Herba Portulacae 20-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15-20 weight portion, Herba Senecionis Scandentis 20-27 weight portion, Radix Ampelopsis 20-26 weight portion, Calculus Bovis 15-24 weight portion, Herba Eupatorii 20-27 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Fructus Amomi Rotundus 15-25 weight portion, Fructus Aurantii Immaturus 18-24 weight portion, fevervine 15-24 weight portion, Poria 15-20 weight portion, Semen Coicis 15-18 weight portion, Caulis Clematidis Armandii 20-24 weight portion, Medulla Junci 15-26 weight portion, Rhizoma Cimicifugae 15-20 weight portion, Mirabilitum crystallina 14-18 weight portion, Folium Bambusae 20-28 weight portion, Herba Sonchi Arvensis 20-29 weight portion, suspension rod fiber crops 3-5 weight portion, pseudobulbus Calanthes fimbriatae 4-5 weight portion, Herba Peperomiae Dindygulensis 15-20 weight portion, Radix Ilicis Asprellae 20-25 weight portion, Herba salviniae natantis 20-25 weight portion, Herba pterocephali 2-3 weight portion, Herba Sedi Multicaulis 15-20 weight portion and Herba Phaenospermatis globosae 18-23 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 20 weight portion, Fructus Forsythiae 18 weight portion, Folium Isatidis 13 weight portion, Flos Chrysanthemi Indici 20 weight portion, Rhizoma Fagopyri Dibotryis 13 weight portion, Semen Oroxyli 14 weight portion, the Radix Pulsatillae 12 weight portion, Herba Portulacae 17 weight portion, Pseudobulbus Cremastrae Seu Pleiones 13 weight portion, Herba Senecionis Scandentis 18 weight portion, Radix Ampelopsis 17 weight portion, Calculus Bovis 14 weight portion, Herba Eupatorii 16 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Fructus Amomi Rotundus 14 weight portion, Fructus Aurantii Immaturus 15 weight portion, fevervine 12 weight portion, Poria 13 weight portion, Semen Coicis 12 weight portion, Caulis Clematidis Armandii 18 weight portion, Medulla Junci 13 weight portion, Rhizoma Cimicifugae 12 weight portion, Mirabilitum crystallina 12 weight portion, Folium Bambusae 17 weight portion, Herba Sonchi Arvensis 16 weight portion, suspension rod fiber crops 6 weight portions, pseudobulbus Calanthes fimbriatae 6 weight portion, Herba Peperomiae Dindygulensis 12 weight portion, Radix Ilicis Asprellae 18 weight portion, Herba salviniae natantis 17 weight portion, Herba pterocephali 4 weight portion, Herba Sedi Multicaulis 12 weight portion and Herba Phaenospermatis globosae 15 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25 weight portion, Fructus Forsythiae 20 weight portion, Folium Isatidis 15 weight portion, Flos Chrysanthemi Indici 24 weight portion, Rhizoma Fagopyri Dibotryis 15 weight portion, Semen Oroxyli 15 weight portion, the Radix Pulsatillae 15 weight portion, Herba Portulacae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Herba Senecionis Scandentis 20 weight portion, Radix Ampelopsis 20 weight portion, Calculus Bovis 15 weight portion, Herba Eupatorii 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Fructus Amomi Rotundus 15 weight portion, Fructus Aurantii Immaturus 18 weight portion, fevervine 15 weight portion, Poria 15 weight portion, Semen Coicis 15 weight portion, Caulis Clematidis Armandii 20 weight portion, Medulla Junci 15 weight portion, Rhizoma Cimicifugae 15 weight portion, Mirabilitum crystallina 14 weight portion, Folium Bambusae 20 weight portion, Herba Sonchi Arvensis 20 weight portion, suspension rod fiber crops 3 weight portions, pseudobulbus Calanthes fimbriatae 4 weight portion, Herba Peperomiae Dindygulensis 15 weight portion, Radix Ilicis Asprellae 20 weight portion, Herba salviniae natantis 20 weight portion, Herba pterocephali 2 weight portion, Herba Sedi Multicaulis 15 weight portion and Herba Phaenospermatis globosae 18 weight portion.
For solving the problems of the technologies described above, present invention also offers a kind of preparation method of described Chinese medicine preparation, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:
The first step, by Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Flos Chrysanthemi Indici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 60% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.22;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 60% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 10 ~ 20 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described oral solutions.
The dosage form of described Chinese medicine preparation is buccal tablet, and its preparation method comprises the following steps:
The first step, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones and Herba Senecionis Scandentis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 80% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci and Rhizoma Cimicifugae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 62 DEG C ~ 72 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.02 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain buccal tablet.
The dosage form of described Chinese medicine preparation is: film coated tablet, sugar coated tablet, hard capsule, soft capsule, buccal tablet, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, powder, solution, sublimed preparation, suppository, plaster, syrup, injection, powder.
The invention has the beneficial effects as follows: the present invention has heat-clearing and toxic substances removing, effect of invigorating the spleen for eliminating dampness, cure mainly recurrent oral ulceration diseases caused by exogenous pathogenic factor seasonal noxious pathogen card.The present invention has and utilizes Traditional Chinese medical theory, and the basis of organic conception regulates animal economy immunity, can antiallergic action, improves microcirculation; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs targeting is comparatively strong, can antiinflammatory, pain relieving, prevent wound surface expansion etc., drug effect is gone directly focus; Safe and effective, not easily produce drug resistance, reduce relapse rate etc.
 
Detailed description of the invention
Motherland's medical science is thought, recurrent oral ulceration is many because of diseases caused by exogenous pathogenic factor dryness-fire, eating and drinking without temperance and giving birth to.As the theory of the bases " all sufferings skin ulcers all belong to the heart " and " tongue is the Seedling of the heart " such as Zhu Shi, think that recurrent oral ulceration is mainly caused by flaming up of heart-fire.Liu Shi then thinks many because of the pungent pure wine of surfeit so that accumulation of heat in the heart and spleen, follow through on attack and send out in mouth: or because of the ferritic deficiency of YIN, excessively, loss is Kidney-Yin for impairment caused by overstrain in addition, hyperactivity of deficient fire and sending out.Somebody thinks the prolonged illness impairment of the spleen, and water is wet not to be transported, strongly fragrant and heat-transformation, caused by damp and hot upper steaming.In a word, primary disease pathogenesis is based on " fire ", relevant with improper diet and overtiredness, physical condition, the closest with the dirty relation of heart spleen two.
Therefore; the present invention treats recurrent oral ulceration diseases caused by exogenous pathogenic factor seasonal noxious pathogen card with heat-clearing and toxic substances removing; invigorating the spleen for eliminating dampness is primary treatment principle, selects prescription: Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci, Rhizoma Cimicifugae, Mirabilitum crystallina, Folium Bambusae, Herba Sonchi Arvensis, suspension rod fiber crops, pseudobulbus Calanthes fimbriatae, Herba Peperomiae Dindygulensis, Radix Ilicis Asprellae, Herba salviniae natantis, Herba pterocephali, Herba Sedi Multicaulis, Herba Phaenospermatis globosae.
Wherein, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Calculus Bovis, Herba Sonchi Arvensis, suspension rod fiber crops, pseudobulbus Calanthes fimbriatae, Herba Peperomiae Dindygulensis, Radix Ilicis Asprellae, Herba salviniae natantis, Herba pterocephali, Herba Sedi Multicaulis heat-clearing and toxic substances removing; Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Herba Phaenospermatis globosae invigorating the spleen for eliminating dampness; Caulis Clematidis Armandii, Medulla Junci, Rhizoma Cimicifugae, Mirabilitum crystallina, Folium Bambusae heat clearing and damp drying, removing toxic substances.Full side's compatibility is rigorous, safe and effective, and the course for the treatment of is shorter, not easily produces drug resistance etc.
Now each taste Chinese medicine is described below:
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc.In addition Flos Lonicerae also have function of gallbladder promoting to protect the liver, antioxidation, blood fat reducing, the effect such as central excitation.
Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the Flos Lonicerae broadly similar such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.Weakness of the spleen and stomach, fever due to deficiency of QI, carbuncle is burst, the light person of the rare color of pus avoids clothes.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.
Folium Isatidis: bitter, cold; Enter liver, the heart, stomach warp.Compendium of Material Medica: " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice, separates Mylabris, Yuan green grass or young crops, tree of heaven chicken, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine just ": " is controlled pestilence pyretic toxicity and goes mad, wind heat macule, and carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.Allly to hold concurrently malicious person with heat, all LANYE should smash juice and use it." heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Resisting pathogenic microbes effect: the in vitro tests of Folium Isatidis decoct has certain inhibitory action to staphylococcus aureus, alpha streptococcus, meningococcus, streptococcus pneumoniae, micrococcus catarrhalis, Bacillus typhi, escherichia coli, hemophilus influenza, diphtheria corynebacterium and dysentery bacterium; Folium Isatidis also has inhibitory action to encephalitis b virus, mumps virus, influenza virus etc. and Folium Isatidis kills leptospiral effect in addition.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent." book on Chinese herbal medicine converges and says ": " removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.
Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.As heat-clearing and toxic substances removing, according to Nantong experience, must take by stewing out of water juice, decoction then curative effect is not remarkable.
Semen Oroxyli: mildly bitter flavor, sweet, cold nature; Return lung, liver, stomach warp." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " broken legendary venomous insect amasss, except the poison of tympanitis due to blood stasis, gas legendary venomous insect for Dingchuan, expectorant.Again can tonify deficiency, alleviating distention in middle-JIAO, feed." " detailed outline is picked up any lost article from the road ": " control heart pain, irritability pain, bottom is damp and hot.Xiang Qiuzi cloud again, all carbuncle poison do not close up, and paste it with this." sore-throat relieving lung moistening, dispersing the stagnated liver-QI for regulating the stomach, expelling pus and promoting granulation.Cure mainly pharyngalgia sore throat, hoarseness, cough, stomachache due to hyperactive liver-QI attacking the stomach, skin infection is burst for a long time and is not held back, acute eczema.Seed, peel of stem, containing baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing.Contain chrysin in seed and peel of stem, have cytotoxic activity to human nasal pharyngeal cancer (KB) cell, its median effective dose is 13mg/ml.
The Radix Pulsatillae: bitter in the mouth, cold in nature; Return stomach warp, large intestine channel." herbal classic is met former ": " Radix Pulsatillae, " herbal classic " says bitter temperature person, and the mistake made private copy of also.It controls the diseases such as the mad easy cold and heat of pyrexial malaria, the disease of all few sun, positive bright pathogenic heat consolidation, and the loose then hematocele of knot goes and only suffers from abdominal pain." not Lu " be epistaxis only, and great scape stops fulminant dysentery, is also the time that pyretic toxicity enters blood trouble and divides." " property of medicine opinion ": " only stomachache and also fulminant dysentery, control toothache, tumor scrofula under major event.Main hundred pain all over the joints." can heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, for pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.Radix Pulsatillae infusion can extend the survival date of suffering from influenza virus PR8 white mice, also has slightly alleviate its pulmonary lesion.
Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property." " Kaibao Bencao ": not " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm." function heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.
Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool.Dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing.Control carbuncle furuncle and phyma, laryngopharynx swelling and pain, sore throat, scrofula.Supplement to the Herbal: " vinegar mill applies it for main carbuncle skin ulcer fistula, scrofula tuberculosis etc." Compendium of Material Medica: " main furuncle swells, counteracting toxic substances broken skin.Separate all poison, snakeworm, mad dog wound.", carbuncle furunculosis, scrofula swollen to acute mastitis go through tuberculosis, for oral administration, external application, all can apply.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth.Supplement to the Herbal: " main pestilential pathogen, knot is yellow, malaria miasma, and cup poison, boils telling down of clothes, also smash the place of biting such as deposited skin ulcer, worm Serpentis dog." " detailed outline is picked up any lost article from the road ": " improving eyesight goes star to hinder.Decoct soup bath skin infection.Canis familiaris L. stings mixes Refined Mercurous chloride with a thousand li cream and pastes it.Treating snakebite." heat clearing away, removing toxic substances, parasite killing, improving eyesight, controls various acute inflammatory disease, wind-fire acute conjunctivitis, corneal nebula, typhoid fever; bacillary dysentery, lobar pneumonia, tonsillitis, enteritis, jaundice, influenza, toxemia; septicemia, carbuncle furuncle poison, dry exudative dermatitis skin ulcer, erysipelas, and eczema, scalds, trichomonal vaginitis.For anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.Herba Senecionis Scandentis has broad ectrum antibiotic effect, has very strong inhibitory action to icterohemorrhagic form leptospira.
Radix Ampelopsis: heat-clearing and toxic substances removing, removing obstruction for relieving pain, promoting tissue regeneration and ulcer healing.Treatment of ulcer toxic swelling, scrofula, scalds, eczema, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, traumatic hemorrhage.Radix Ampelopsis decoct itself without analgesic activity, but significantly can strengthen RADIX ACONITI LATERALIS PREPARATA and process the analgesic activity of Radix Aconiti, antagonism RADIX ACONITI LATERALIS PREPARATA, contraction to isolated frog heart when processing Radix Aconiti and Radix Aconiti Kusnezoffii Preparata.In vitro tests has inhibitory action to human cervical carcinoma cell training system JTC-26, and suppression ratio is more than 90%.
Calculus Bovis: bitter, cool; GUIXIN, Liver Channel.Clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.Calculus Bovis has certain sedation, significantly anticonvulsant action and refrigeration function.The mouse peritoneal capillary permeability increase that Calculus Bovis Dichlorodiphenyl Acetate causes, polymorphonuclear cell migration and rat formaldehyde filter paper granulation tissue hyperplasia all have strong inhibitory action.Calculus Bovis obviously can strengthen the myocardial contraction of isolated frog heart, guinea pig heart and cat heart papillary muscles, and heart rate increases simultaneously, but then makes it to shrink to coronary vasodilator.Calculus Bovis popularity encephalitis b virus has direct deactivation. and to the subcutaneous infection encephalitis b virus mice of 24 hours, use Calculus Bovis gavage, then have significant protective effect to infecting mouse.
Herba Eupatorii: pungent, flat.Return spleen, stomach, lung meridian.Shennong's Herbal: " main dredging water passages, kills diseases due to noxious agents produced by various parasites, eliminating turbid pathogens.Take QI invigorating for a long time, make light of one's life by commiting suicide not old, being proficient in the law of natural movement." " Chinese medicinal herbal ": " deliver damp eliminating, and middleization is turbid.Control summer-heat headache, lossless heating, abdominal distention uncomfortable in chest, sweet greasy in mouth, halitosis." expelling summer-heat and damp, ward off dirty and in.For experiencing heat-damp in summer, cold and heat are had a headache, and accumulate in moistening, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, disappears truly, turbid damp obstructing in middle-JIAO, and gastral cavity painful abdominal mass vomiting and nausea is sweet greasy in mouth, halitosis, sialism, and heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.Volatile oil of Herba Eupatorii popularity cold virus has inhibitory action, can cause cattle and sheep chronic poisoning, infringement kidney, liver and raw diabetes.Herba Eupatorii 100% water decoction, with tube dilution method, has inhibitory action to diphtheria corynebacterium, staphylococcus aureus, sarcina, Bacillus proteus, Bacillus typhi etc.Its volatile oil infected by influenza has inhibitory action.
Cortex Magnoliae Officinalis: bitter, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Function: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and have stomach invigorating digestion-aid effect.Experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis.Experiment shows, compares with other 61 kinds of Chinese medicines, and the effect of Cortex Magnoliae Officinalis to Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi is the strongest. it act as bactericidal action to Staphylococcus albus and bacillus subtilis.In vitro, to the inhibitory action of staphylococcus aureus, comparatively Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei are strong to Cortex Magnoliae Officinalis.
Fructus Amomi Rotundus: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting, the card such as not disappear for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, dyspepsia.Methyleugenol in this product volatile oil and elemicine, to mice, rabbit, cat and Canis familiaris L., have anesthetic action after iv administration.The Mouse Uterus cancer that Fructus Amomi Rotundus brings out MCA and DMBA and cutaneous papilloma have inhibitory action.Contained by these product, volatile oil has stimulation to gastrointestinal tract, and has the effect of dispeling the wind.Fructus Amomi Rotundus ether has hallucinogenic action to normal person, has moderate excitation to the brain of people.Fructus Amomi Rotundus and myristicin all can strengthen the effect of tryptamines.Methyleugenol in this product volatile oil and elemicine, to mice, rabbit, cat and Canis familiaris L., have anesthetic action after iv administration.
Fructus Aurantii Immaturus: bitter, pungent, cold; Return spleen, stomach, liver, heart channel.Compendium of Material Medica: " trifoliate orange is wooden name, is its son in fact, therefore says Fructus Aurantii Immaturus.Descendant, because of little person's property speed, exhales again the old to be Fructus Aurantii.Raw then skin depth and reality, ripe then shell is thin and empty, and as the justice of the old Pericarpium Citri tangerinae of blue or green Pericarpium Citri tangerinae, people Song appears again Fructus Aurantii one, non-.Kou Shi thinks brokenly solid and name, also inevitable." " medication heart method ": " and Fructus Aurantii Immaturus, clean Gu spends spleen channel hematocele, therefore can remove epigastric oppression, spleen without hematocele, then not painful abdominal mass under the heart." property sedimentation and descending, function is regulated the flow of vital energy except painful abdominal mass, and with except breast abdomen feeling of fullness, double numbness of reducing phlegm out, removing food stagnancy, with intestinal stasis relieving, is high dose of dispelling the stagnated QI knot in fact, controls feeling of fullness, leads stagnant key medicine.Have again an energy of raising blood pressure, control the use of prolapse of the uterus proctoptosis.
Fevervine: property is put down, sweet in the mouth, micro-hardship." the SHENGCAO property of medicine is standby to be wanted ": " its head controls new internal injury, and pot is carnivorous, and tonify deficiency kidney tonifying, except fire is enriched blood; Wash skin ulcer pain relieving, the loose poison of the heat that disappears.Its leaf beats rice with confectionery, dysentery relieving." " Zhiwu Mingshi Tukao ": " be wash, removing toxic substances, removes wind, heat clearing away, cold expelling.Apply innominate toxic swelling, and mend muscles and bones." expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.Fevervine total alkaloids lumbar injection can suppress mice voluntary activity, extends pentobarbital sodium length of one's sleep, has certain sedation.Fevervine total alkaloids can suppress myenteron to shrink, and the myenteron contracture caused by energy antagonism acetylcholine.Fevervine decoct has inhibitory action to S. aureus in vitro and Fu Shigella flexneri, and extractum also has bacteriostasis to staphylococcus aureus and streptococcus pneumoniae.
Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, there is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea, Semen Coicis can be used as medicine, and is used for treating edema, beriberi, diarrhea due to hypofunction of the spleen etc.Make skin smooth, reduce wrinkle, eliminate effect of pigment spot.Have obvious curative effect to face acne and pachylosis, in addition, it also has absorbability to ultraviolet, and its extractive matter adds in cosmetics also can reach sun-proof and effect that is anti-ultraviolet.Be suitable for various cancer patient, arthritis, acute and chronic nephritis edema, cancer ascites, puffiness of the face and limbs, vitamin B1 deficiency edema person, warty vegetation, beauty treatment person, juvenile verruca plana, common wart, molluscum contagiosum, young acne pimple and the coarse person of other skin malnutrition, be suitable for consumptive lung disease, lung abscess person eats.
Caulis Clematidis Armandii: bitter, cold in nature; Enter heart channel, small intestine meridian, urinary bladder channel.Collective Notes to the Canon of Materia medica: " Medulla Tetrapanacis, the present goes out shortcut, raw around timbo, and juice is white, and stem has pore, and two is all logical, blows it containing one, then to go out those persons good for gas.Or cloud and Weed rattan." " property of medicine opinion ": " cure mainly five types of stranguria, diuresis, switch lattice.Control people to sleep, main edema is floating large, heat clearing away and restlessness relieving more." function inducing diuresis for treating stranguria syndrome, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow.For stranguria, edema, vexed dark coloured urine, amenorrhea breast is few, damp and hot arthralgia pain.This product energy inducing diuresis to remove edema, lower dampness removing heat, makes that damp and hot heresy is descending discharges from urine.Can the fire of supernatant heart channel, under let out the heat of small intestinal.
Medulla Junci: to be slightly cold, sweet, light; GUIXIN, lung, small intestinal, urinary bladder channel." Bencao Jingshu ": " Medulla Junci, its light weight leads to, and it is cold in nature, slightly sweet flavor, therefore can tonneau small intestinal steam, descendingly goes out from urine, and small intestinal is the internal organs of the heart, therefore also except heart channel heat also." function relieving stranguria by diuresis, clearing heart fire.Cure mainly: gonorrhea, edema, dysuria, the puckery pain of oliguria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, aphtha of the mouth and tongue, wound.Experiment proves that this product has diuresis, anastalsis.Treating acute and chronic pharyngitis, stomatitis.
Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp." property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Except cardiopulmonary pathogenic wind toxic heat is obstructed and constipated, aphtha, unhappy.Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer." Compendium of Material Medica: " speckle removing rash, clots absorbing blood are controlled sun and are fallen into dizzy fortune, the empty pain of the breast side of body, heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." function heat-clearing and toxic substances removing, rash.Not smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome is thoroughly sent out, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.
Mirabilitum crystallina: pungent, salty, cold; GUIXIN, stomach, kidney channel." Mingyi Bielu ": " Mirabilitum crystallina, color is as Muscovitum, and removable person is good, and salt essence also.You Zhongshui county, raw Radix Dichroae mountain valley and Handan." Compendium of Material Medica: " control white urine, interior numbness, removing heat from blood pathogenic fire reducing, only has a toothache, and hard tooth is bright." row calentura when curing mainly, high fever excessive thirst, laryngopharynx swelling and pain, edema, urine retention, aphtha of the mouth and tongue, carbuncle, erysipelas, scalds.Mirabilitum crystallina treating disorders in five ZANG-organs six internal organs amass ripe, the capable seasonal epidemic pathogens plague fever in sky, so that stuffy sensation with restlessness is quenched one's thirst, curing the wound cold going mad, or abandon clothing and run.Control the wind heat heart hot-tempered, xerostomia raving, from head to foot high fever and in all poison.
Folium Bambusae: nature and flavor, sweet, be slightly cold.Compendium of Material Medica: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome." vegetation is side just ": " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.Folium Bambosae extract is a kind of bioflavonoid health care nutrient newly developed, has excellent antiradical activities and conclusive quasi-SOD activity; Can compare favourably with VC to the blocking ability of nitrosation reaction; Effect and the pollen of defying age, anti-stress and resisting fatigue are suitable; Blood fat reducing and cholesterolemia, antioxidative effect are identical with Folium Ginkgo extract; Antibacterial, antiinflammatory is similar to tea polyphenols with antivirus action; Effect victory Succus Bambusae one of relieving cough and expelling phlegm, heat-clearing and toxic substances removing is raised; And there is significant immunological enhancement, the resistance of human body to poor environment and disease can be improved: the Folium Bambusae delicate fragrance also with good hydrothermal stability, antioxidative stabilizer and uniqueness.Not containing any harmful components and antinutritional factor, without toxicity, side effect, be a kind of very good pure natural health-care.
Herba Sonchi Arvensis: nature and flavor " Hebei Chinese medicine handbook ": " cold in nature, bitter in the mouth." function cures mainly heat-clearing and toxic substances removing, tonify deficiency cough-relieving.Control bacillary dysentery, laryngitis, weak cough, internal hemorrhoid is deviate from, leucorrhea.1. " Hebei Chinese medicine handbook ": " heat-clearing and toxic substances removing.Control acute bacillary dysentery, acute laryngitis, internal hemorrhoid is deviate from." 2. " the common identification obscuring Chinese herbal medicine ": " controls leucorrhea and postnatal blood stasis stomachache, appendicitis."
Suspension rod fiber crops: nature and flavor are " Guizhou medical herbs " 1.: " acrid in the mouth, cool in nature, slightly poisonous." 2. " Shaanxi Chinese herbal medicine ": " bitter in the mouth, cold in nature, slightly poisonous." 1. function cures mainly " Guizhou medical herbs ": " clearing heat for promoting eruption, relaxing muscles and tendons and activating QI and blood in the collateral, regulating menstruation." 2. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, detumescence, parasite killing.Control tinea alba, impetigo, fracture swells and ache, and vagina is itched."
Pseudobulbus Calanthes fimbriatae: the orchid family Calanthe plant Diffuse Coptosapelta calanthe Calanthe fimbriata Franch. and sword-like leave calanthe (narrow leaf calanthe) C. davidi Franch., is used as medicine with pseudobulb and root.Summer excavates, and cleans, dries.Nature and flavor are pungent, bitter, cool.Function cures mainly heat-clearing and toxic substances removing, scattered silt pain relieving.For gastric ulcer, acute gastric dilatation, chronic hepatitis, lumbago, stomachache, lymphoid tuberculosis, chronic pharyngitis, toothache, sand Stranguria, amenorrhea, arthralgia, venom, traumatic injury.
Herba Peperomiae Dindygulensis: nature and flavor are pungent is cool.1. " choosing of Yunnan Chinese herbal medicine ": " pungent light, flat." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " is cool in nature, lightly seasoned." 1. function cures mainly " choosing of Yunnan Chinese herbal medicine ": " eliminating stasis and resolving masses, anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, detumescence dissipating blood stasis, pain relieving diuretic.Control traumatic injury, scald burn, carbuncle furuncle, oedema due to nephritis, pulmonary tuberculosis, asthma, tracheobronchitis, cough due to lung-heat."
Radix Ilicis Asprellae: property bitter but sweet flavor. cold.1. " south of the Five Ridges gather medicinal herbs record ": " bitter in the mouth." 2. " Luchuan book on Chinese herbal medicine ": " is sweet, cold." 3. " Nanning City's medicine will ": " is sweet, flat, nontoxic." function cures mainly heat clearing away, promotes the production of body fluid, and invigorates blood circulation, removing toxic substances.Cure cold, have a headache dizzy, calentura is yearningly dry, eruptive disease, diarrhea of heat type, lung abscess, hemoptysis, laryngalgia, hemorrhoidal bleeding, gonorrhea, carbuncle poison, traumatic injury.1. " the SHENGCAO property of medicine is standby to be wanted ": " kill Ci, reason traumatic injury." 2. " south of the Five Ridges gather medicinal herbs record ": " heat clearing away poison.Decoct herbal tea multiplex it.Control sarcoptic mite again." 3. " Luchuan book on Chinese herbal medicine ": " refreshing and detoxicating, antidiarrheal of promoting the production of body fluid.Control calentura dryness of the mouth and thirst, diarrhea of heat type, general larynx disease." 4. " Nanning City's medicine will ": " heat-clearing and toxic substances removing. lung moistening is quenched the thirst.Soothe sore throat thirsty, hemoptysis, eruptive disease." 5. " practical Chinese herbal medicine ": " treating acute tonsillitis, pharyngolaryngitis, pulmonary abscess, flu."
Herba salviniae natantis: nature and flavor are " the south of Fujian Province traditional herbal medicine " 1.: " bitter, flat." 2. " Chinese herbal medicine is commonly used in Shanghai ": " is pungent, cold." function cures mainly and controls consumptive fever, edema, furuncle, eczema, burning hot wound.1. " Chinese herbal medicine is commonly used in Shanghai ": " heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Control carbuncle furunculosis, the long-pending pain of blood stasis." 2. " Guizhou medical herbs >: " heat clearing away, dehumidifying, detumescence."
Herba pterocephali: be born in the places such as alpine meadow, roadside and stone gap.The ground such as distribution Yunnan, Sichuan, Tibet.Chemical analysis is containing alkaloid, flavonoid glycoside.Nature and flavor " Chinese herbal medicine is commonly used in Tibet ": " bitter, cold." 1. function cures mainly " Chinese herbal medicine is commonly used in Tibet ": " heat-clearing and toxic substances removing, wind-damp dispelling, pain relieving.The fever that cures cold and the heat symptom-complex caused by various infectious disease, heat in the heart, heat in blood etc." 2. " plateau Chinese herbal treatment handbook ": " detoxifies antibacterial.Control carbuncle skin ulcer furunculosis, influenza measles."
Herba Sedi Multicaulis: nature and flavor " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold nature, sweet in the mouth is micro-pungent." function cures mainly heat-clearing and toxic substances removing, hemostasis, wind-damp dispelling.Control laryngopharynx swelling and pain, epistaxis, wind heat is dizzy, rheumatic arthritis, nasal eczema, eczema, sore.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control laryngopharynx swelling and pain, disappear tonsillitis, network anemofrigid-damp arthralgia of passing through, and bones and muscles pain washes the damp and hot poison of skin ulcer." 2. " this sketch of the southern regions of the Yunnan Province is said ": " smashes deposited fontanel, and only epistaxis is more than, and bag is injured also good." 3. " Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, hemostasis, blood pressure lowering, wind-damp dispelling."
Herba Phaenospermatis globosae: ecological environment: hillside sylvan life, the mountain valley small stream of being born in height above sea level 150-1800m take up roadside thick grass.Resource distribution: be distributed in the ground such as East China, Central China, southwest and Shaanxi, Gansu, Tibet.Nature and flavor are sweet; Micro-puckery; Flat.Function cures mainly tonify deficiency spleen invigorating; Promoting blood flow to regulate menstruation.Main body is after being ill empty; Amenorrhea.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 15-30 weight portion, Fructus Forsythiae 10-28 weight portion, Folium Isatidis 10-18 weight portion, Flos Chrysanthemi Indici 14-32 weight portion, Rhizoma Fagopyri Dibotryis 10-20 weight portion, Semen Oroxyli 10-24 weight portion, Radix Pulsatillae 10-20 weight portion, Herba Portulacae 13-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion, Herba Senecionis Scandentis 13-27 weight portion, Radix Ampelopsis 13-26 weight portion, Calculus Bovis 10-24 weight portion, Herba Eupatorii 12-27 weight portion, Cortex Magnoliae Officinalis 10-20 weight portion, Fructus Amomi Rotundus 10-25 weight portion, Fructus Aurantii Immaturus 13-24 weight portion, fevervine 10-24 weight portion, Poria 10-20 weight portion, Semen Coicis 10-18 weight portion, Caulis Clematidis Armandii 12-24 weight portion, Medulla Junci 12-26 weight portion, Rhizoma Cimicifugae 10-20 weight portion, Mirabilitum crystallina 10-18 weight portion, Folium Bambusae 15-28 weight portion, Herba Sonchi Arvensis 14-29 weight portion, suspension rod fiber crops 3-8 weight portion, pseudobulbus Calanthes fimbriatae 4-7 weight portion, Herba Peperomiae Dindygulensis 10-20 weight portion, Radix Ilicis Asprellae 13-25 weight portion, Herba salviniae natantis 12-25 weight portion, Herba pterocephali 2-5 weight portion, Herba Sedi Multicaulis 10-20 weight portion, Herba Phaenospermatis globosae 12-23 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25-30 weight portion, Fructus Forsythiae 20-28 weight portion, Folium Isatidis 15-18 weight portion, Flos Chrysanthemi Indici 24-32 weight portion, Rhizoma Fagopyri Dibotryis 15-20 weight portion, Semen Oroxyli 15-24 weight portion, Radix Pulsatillae 15-20 weight portion, Herba Portulacae 20-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15-20 weight portion, Herba Senecionis Scandentis 20-27 weight portion, Radix Ampelopsis 20-26 weight portion, Calculus Bovis 15-24 weight portion, Herba Eupatorii 20-27 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Fructus Amomi Rotundus 15-25 weight portion, Fructus Aurantii Immaturus 18-24 weight portion, fevervine 15-24 weight portion, Poria 15-20 weight portion, Semen Coicis 15-18 weight portion, Caulis Clematidis Armandii 20-24 weight portion, Medulla Junci 15-26 weight portion, Rhizoma Cimicifugae 15-20 weight portion, Mirabilitum crystallina 14-18 weight portion, Folium Bambusae 20-28 weight portion, Herba Sonchi Arvensis 20-29 weight portion, suspension rod fiber crops 3-5 weight portion, pseudobulbus Calanthes fimbriatae 4-5 weight portion, Herba Peperomiae Dindygulensis 15-20 weight portion, Radix Ilicis Asprellae 20-25 weight portion, Herba salviniae natantis 20-25 weight portion, Herba pterocephali 2-3 weight portion, Herba Sedi Multicaulis 15-20 weight portion, Herba Phaenospermatis globosae 18-23 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 20 weight portion, Fructus Forsythiae 18 weight portion, Folium Isatidis 13 weight portion, Flos Chrysanthemi Indici 20 weight portion, Rhizoma Fagopyri Dibotryis 13 weight portion, Semen Oroxyli 14 weight portion, the Radix Pulsatillae 12 weight portion, Herba Portulacae 17 weight portion, Pseudobulbus Cremastrae Seu Pleiones 13 weight portion, Herba Senecionis Scandentis 18 weight portion, Radix Ampelopsis 17 weight portion, Calculus Bovis 14 weight portion, Herba Eupatorii 16 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Fructus Amomi Rotundus 14 weight portion, Fructus Aurantii Immaturus 15 weight portion, fevervine 12 weight portion, Poria 13 weight portion, Semen Coicis 12 weight portion, Caulis Clematidis Armandii 18 weight portion, Medulla Junci 13 weight portion, Rhizoma Cimicifugae 12 weight portion, Mirabilitum crystallina 12 weight portion, Folium Bambusae 17 weight portion, Herba Sonchi Arvensis 16 weight portion, suspension rod fiber crops 6 weight portions, pseudobulbus Calanthes fimbriatae 6 weight portion, Herba Peperomiae Dindygulensis 12 weight portion, Radix Ilicis Asprellae 18 weight portion, Herba salviniae natantis 17 weight portion, Herba pterocephali 4 weight portion, Herba Sedi Multicaulis 12 weight portion, Herba Phaenospermatis globosae 15 weight portion.
The ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25 weight portion, Fructus Forsythiae 20 weight portion, Folium Isatidis 15 weight portion, Flos Chrysanthemi Indici 24 weight portion, Rhizoma Fagopyri Dibotryis 15 weight portion, Semen Oroxyli 15 weight portion, the Radix Pulsatillae 15 weight portion, Herba Portulacae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Herba Senecionis Scandentis 20 weight portion, Radix Ampelopsis 20 weight portion, Calculus Bovis 15 weight portion, Herba Eupatorii 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Fructus Amomi Rotundus 15 weight portion, Fructus Aurantii Immaturus 18 weight portion, fevervine 15 weight portion, Poria 15 weight portion, Semen Coicis 15 weight portion, Caulis Clematidis Armandii 20 weight portion, Medulla Junci 15 weight portion, Rhizoma Cimicifugae 15 weight portion, Mirabilitum crystallina 14 weight portion, Folium Bambusae 20 weight portion, Herba Sonchi Arvensis 20 weight portion, suspension rod fiber crops 3 weight portions, pseudobulbus Calanthes fimbriatae 4 weight portion, Herba Peperomiae Dindygulensis 15 weight portion, Radix Ilicis Asprellae 20 weight portion, Herba salviniae natantis 20 weight portion, Herba pterocephali 2 weight portion, Herba Sedi Multicaulis 15 weight portion, Herba Phaenospermatis globosae 18 weight portion.
For solving the problems of the technologies described above, present invention also offers a kind of preparation method of described Chinese medicine preparation, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:
The first step, by Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Flos Chrysanthemi Indici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 60% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.22;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 60% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 10 ~ 20 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described oral solutions.
The dosage form of described Chinese medicine preparation is buccal tablet, and its preparation method comprises the following steps:
The first step, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones and Herba Senecionis Scandentis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 80% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci and Rhizoma Cimicifugae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 62 DEG C ~ 72 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.02 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain buccal tablet.
The dosage form of described Chinese medicine preparation is: film coated tablet, sugar coated tablet, hard capsule, soft capsule, buccal tablet, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, powder, solution, sublimed preparation, suppository, plaster, syrup, injection, powder.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 oral solutions
Flos Lonicerae 20 weight portion, Fructus Forsythiae 18 weight portion, Folium Isatidis 13 weight portion, Flos Chrysanthemi Indici 20 weight portion, Rhizoma Fagopyri Dibotryis 13 weight portion, Semen Oroxyli 14 weight portion, the Radix Pulsatillae 12 weight portion, Herba Portulacae 17 weight portion, Pseudobulbus Cremastrae Seu Pleiones 13 weight portion, Herba Senecionis Scandentis 18 weight portion, Radix Ampelopsis 17 weight portion, Calculus Bovis 14 weight portion, Herba Eupatorii 16 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Fructus Amomi Rotundus 14 weight portion, Fructus Aurantii Immaturus 15 weight portion, fevervine 12 weight portion, Poria 13 weight portion, Semen Coicis 12 weight portion, Caulis Clematidis Armandii 18 weight portion, Medulla Junci 13 weight portion, Rhizoma Cimicifugae 12 weight portion, Mirabilitum crystallina 12 weight portion, Folium Bambusae 17 weight portion, Herba Sonchi Arvensis 16 weight portion, suspension rod fiber crops 6 weight portions, pseudobulbus Calanthes fimbriatae 6 weight portion, Herba Peperomiae Dindygulensis 12 weight portion, Radix Ilicis Asprellae 18 weight portion, Herba salviniae natantis 17 weight portion, Herba pterocephali 4 weight portion, Herba Sedi Multicaulis 12 weight portion, Herba Phaenospermatis globosae 15 weight portion.
Its preparation method is:
The first step, by Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Flos Chrysanthemi Indici mixing, add relative to mixture 5 times amount determining alcohol be 60% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 times of water gagings, boils 2 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.22;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 60%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 10 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 20 minutes, and temperature is 100 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described oral solutions.
Embodiment 2 buccal tablet
Flos Lonicerae 25 weight portion, Fructus Forsythiae 20 weight portion, Folium Isatidis 15 weight portion, Flos Chrysanthemi Indici 24 weight portion, Rhizoma Fagopyri Dibotryis 15 weight portion, Semen Oroxyli 15 weight portion, the Radix Pulsatillae 15 weight portion, Herba Portulacae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Herba Senecionis Scandentis 20 weight portion, Radix Ampelopsis 20 weight portion, Calculus Bovis 15 weight portion, Herba Eupatorii 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Fructus Amomi Rotundus 15 weight portion, Fructus Aurantii Immaturus 18 weight portion, fevervine 15 weight portion, Poria 15 weight portion, Semen Coicis 15 weight portion, Caulis Clematidis Armandii 20 weight portion, Medulla Junci 15 weight portion, Rhizoma Cimicifugae 15 weight portion, Mirabilitum crystallina 14 weight portion, Folium Bambusae 20 weight portion, Herba Sonchi Arvensis 20 weight portion, suspension rod fiber crops 3 weight portions, pseudobulbus Calanthes fimbriatae 4 weight portion, Herba Peperomiae Dindygulensis 15 weight portion, Radix Ilicis Asprellae 20 weight portion, Herba salviniae natantis 20 weight portion, Herba pterocephali 2 weight portion, Herba Sedi Multicaulis 15 weight portion, Herba Phaenospermatis globosae 18 weight portion.
Its preparation method is:
The first step, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones and Herba Senecionis Scandentis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 80% of 5 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci and Rhizoma Cimicifugae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% of 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 62 DEG C 60 DEG C, relative density is the mastic of 1.20, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 5 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 3 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.1 times, the microcrystalline Cellulose of 0.05 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.02 times obtained, then with decompressor by granule tabletted, obtain buccal tablet.
Embodiment 3 powder
Flos Lonicerae 25g, Fructus Forsythiae 20g, Folium Isatidis 15g, Flos Chrysanthemi Indici 24g, Rhizoma Fagopyri Dibotryis 15g, Semen Oroxyli 15g, Radix Pulsatillae 15g, Herba Portulacae 20g, Pseudobulbus Cremastrae Seu Pleiones 15g, Herba Senecionis Scandentis 20g, Radix Ampelopsis 20g, Calculus Bovis 15g, Herba Eupatorii 20g, Cortex Magnoliae Officinalis 15g, Fructus Amomi Rotundus 15g, Fructus Aurantii Immaturus 18g, fevervine 15g, Poria 15g, Semen Coicis 15g, Caulis Clematidis Armandii 20g, Medulla Junci 15g, Rhizoma Cimicifugae 15g, Mirabilitum crystallina 14g, Folium Bambusae 20g, Herba Sonchi Arvensis 20g, suspension rod fiber crops 3g, pseudobulbus Calanthes fimbriatae 4g, Herba Peperomiae Dindygulensis 15g, Radix Ilicis Asprellae 20g, Herba salviniae natantis 20g, Herba pterocephali 2g, Herba Sedi Multicaulis 15g, Herba Phaenospermatis globosae 18g.
Its preparation method is:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract; Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders; 3rd step, adds the starch relative to its quality 4 times in the micropowders obtained by second step, mixing, obtains powder.
 
The toxicity test of medicine
1, acute toxicity test method: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Oral solutions gavage prepared by embodiments of the invention 1, gavage volume is 5ml/kg(and unit dosage form is 32.5g crude drug/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.5g crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.0 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 783 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is low, clinical drug safety.
2, cumulative toxicity test method: select 20 healthy mices, female, each 10 of hero, with the buccal tablet of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.28LD50,0.36LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1400,1800,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.
3, acute oral toxicity test: a time per os gives ICR mice, body weight 18g ~ 22g, 20, the powder distilled water embodiment of the present invention 3 obtained dissolves, and obtains given low 5000mg/kg body weight, gavage amount 20ml/kg, observe 15 days, experimental animal does not find poisoning manifestations, without dead, place's post mortem is obviously not abnormal, judges that Chinese medicine preparation of the present invention is to the nontoxic level in the true border of chmice acute Oral toxicity.
 
Clinical trial
1 data and method
Since selecting year May in May, 2011 to 2012, diseases caused by exogenous pathogenic factor seasonal noxious pathogen type Blood of Patients with Recurrent Oral totally 400 examples of my institute's treatment.Wherein, man 204 example, female 196 example, patient age span is larger.10 years old-15 years old patients are 70 examples, and 16 years old-28 years old patients are 170 examples, 28-60 year patient be 160 examples.Clinical manifestation is after diseases caused by exogenous pathogenic factor 1 ~ 2 day, with diseases caused by exogenous pathogenic factor symptom.From the beginning of oral mucosa contrafluxion, redness, there is chestnut grain sample small red dot or exanthema vesiculosum in the tip of the tongue or lip, herpes diabrosis in 12 hours in hypodynia, in table fester, and clear border.At random patient is divided into four groups, oral liquid treatment group, buccal tablet treatment group, powder treatment group and matched group, each group 100 people.Four groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
Diagnostic criteria
1, there is certain self limiting, just can well heal within 7 ~ 10 days greatly.
2, the cycle of outbreak is not etc., namely intermittent outbreak.
3, surface occurs oozing out and the sensation of causalgia, and the shape of ulcer is circular, oval etc., and size is also not identical.
4, be generally all single-shot or multiple, often occur in the places such as lip, cheek and tongue.
5, most patients does not have the performance of general, but the head of ulcer is larger, and very dark.Diameter is and Submucosa even muscle layer dark at 10 ~ 30mm generally, can leave cicatrix after curing.
6, after diseases caused by exogenous pathogenic factor 1 ~ 2 day, with diseases caused by exogenous pathogenic factor symptom.From the beginning of oral mucosa contrafluxion, redness, there is chestnut grain sample small red dot or exanthema vesiculosum in the tip of the tongue or lip, herpes diabrosis in 12 hours in hypodynia, in table fester, and clear border.
Therapeutic Method
Oral liquid treatment group: this is organized 100 people and uses embodiments of the invention 1 oral solutions to treat.Every day 3 times, each 20ml 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment, follow up a case by regular visits to a year and a half after treatment.
Buccal tablet treatment group: this is organized 100 people and uses embodiments of the invention 2 buccal tablet to treat.Every day 3 times, each 1, buccal 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment, follow up a case by regular visits to a year and a half after treatment.
Powder treatment group: this is organized 100 people and uses embodiments of the invention 3 powder to treat.Every day 3 times, each 0.5mg, is sprinkling upon on wound surface, within 7 days, is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment, follow up a case by regular visits to a year and a half after treatment.
Matched group: this is organized 100 people and uses cydiodine (cydiodine) sheet, every sheet 0.8mg, 3 times/d, each 1, buccal 7 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment, follow up a case by regular visits to a year and a half after treatment.
Criterion of therapeutical effect
1. fully recover: ulcer surface heals, mucosa is normal, and does not recur in 1 year; 2. effective: canker sores alleviates, hyperemia is around gone down, and ulcer surface slightly reduces; Recurrence in ulcer 1 year, but recurrent number comparatively before few 3-5 time, duration of seizure minimizing 3-5 days, attack degree alleviates; 3. effective: attack times, degree are comparatively front to take a turn for the better, but does not still reach effective standard; 4. invalid: after treatment, recurrence is compared without significant difference with before treatment.
Therapeutic outcome
Table 1 is the therapeutic effect contrast of each group
Group Recovery from illness Effective Effectively Invalid
Oral liquid treatment group 97（97%） 2（2%） 1（1%） 0（0%）
Buccal tablet treatment group 97（97%） 1（1%） 2（2%） 0（0%）
Powder treatment group 96（96%） 3（3%） 1（1%） 0（0%）
Matched group 60（60%） 5（5%） 5（5%） 30（30%）
As can be seen from Table 1, the therapeutic effect of three treatment groups is obviously all better than matched group, it can thus be appreciated that Chinese medicine preparation of the present invention, and treatment diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration, good effect, determined curative effect.
Table 2 is the recovery from illness recurrence contrast of each group
Group Recovery from illness number Recurrence
Oral liquid treatment group 97 0（0%）
Buccal tablet treatment group 97 0（0%）
Powder treatment group 96 0（0%）
Matched group 60 10（16.67%）
As can be seen from Table 2, the treatment recovery from illness number of three treatment groups, in follow-up observation, recurrence does not have, and some appearance recurrence of matched group.It can thus be appreciated that Chinese medicine preparation of the present invention, on treatment diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration, therapeutic effect is good, not easily recurs.
Table 3 is the side effect contrast of each group
Group There is number in side effect Side effect occurrence rate
Oral liquid treatment group 0 0
Buccal tablet treatment group 0 0
Powder treatment group 0 0
Matched group 19 19%
As can be seen from Table 3, not there is side effect in the patient of three treatment groups, and side effect appears in matched group patient over the course for the treatment of over the course for the treatment of, the side effect such as erythra, skin pruritus.It can thus be appreciated that Chinese medicine preparation of the present invention, on treatment diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration, treatment can not have side effects, safe and effective.
In sum, Chinese medicine preparation of the present invention, on treatment diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration, therapeutic effect is good, and curative effect is fast, and determined curative effect is safe and effective, without recurrence, and has no side effect.
Typical case: grandson, man, 28 years old, suffer from recurrent oral ulceration, have repeated relapsing, outbreak symptom is after diseases caused by exogenous pathogenic factor 1 ~ 2 day, from the beginning of oral mucosa contrafluxion, redness, hypodynia, there is chestnut grain sample exanthema vesiculosum in the tip of the tongue, herpes diabrosis in 12 hours, in table fester, clear border, is diagnosed as diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration, uses the buccal tablet of the embodiment of the present invention 2 to treat.3 times on the one, one time 1, every sheet 0.8mg, buccal 7 days is a course for the treatment of, treats 3 courses for the treatment of.In drug administration process, there is not untoward reaction in grandson, and after taking medicine, symptom is fully recovered, and a year and a half is observed in later stage follow-up, does not recur again.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine preparation of diseases caused by exogenous pathogenic factor seasonal noxious pathogen type recurrent oral ulceration; it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci, Rhizoma Cimicifugae, Mirabilitum crystallina, Folium Bambusae, Herba Sonchi Arvensis, suspension rod fiber crops, pseudobulbus Calanthes fimbriatae, Herba Peperomiae Dindygulensis, Radix Ilicis Asprellae, Herba salviniae natantis, Herba pterocephali, Herba Sedi Multicaulis and Herba Phaenospermatis globosae.
2. Chinese medicine preparation according to claim 1, is characterized in that, the ratio of weight and number of described raw medicinal material is: Flos Lonicerae 15-30 weight portion, Fructus Forsythiae 10-28 weight portion, Folium Isatidis 10-18 weight portion, Flos Chrysanthemi Indici 14-32 weight portion, Rhizoma Fagopyri Dibotryis 10-20 weight portion, Semen Oroxyli 10-24 weight portion, Radix Pulsatillae 10-20 weight portion, Herba Portulacae 13-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 10-20 weight portion, Herba Senecionis Scandentis 13-27 weight portion, Radix Ampelopsis 13-26 weight portion, Calculus Bovis 10-24 weight portion, Herba Eupatorii 12-27 weight portion, Cortex Magnoliae Officinalis 10-20 weight portion, Fructus Amomi Rotundus 10-25 weight portion, Fructus Aurantii Immaturus 13-24 weight portion, fevervine 10-24 weight portion, Poria 10-20 weight portion, Semen Coicis 10-18 weight portion, Caulis Clematidis Armandii 12-24 weight portion, Medulla Junci 12-26 weight portion, Rhizoma Cimicifugae 10-20 weight portion, Mirabilitum crystallina 10-18 weight portion, Folium Bambusae 15-28 weight portion, Herba Sonchi Arvensis 14-29 weight portion, suspension rod fiber crops 3-8 weight portion, pseudobulbus Calanthes fimbriatae 4-7 weight portion, Herba Peperomiae Dindygulensis 10-20 weight portion, Radix Ilicis Asprellae 13-25 weight portion, Herba salviniae natantis 12-25 weight portion, Herba pterocephali 2-5 weight portion, Herba Sedi Multicaulis 10-20 weight portion and Herba Phaenospermatis globosae 12-23 weight portion.
3. Chinese medicine preparation according to claim 1 and 2, is characterized in that, the ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25-30 weight portion, Fructus Forsythiae 20-28 weight portion, Folium Isatidis 15-18 weight portion, Flos Chrysanthemi Indici 24-32 weight portion, Rhizoma Fagopyri Dibotryis 15-20 weight portion, Semen Oroxyli 15-24 weight portion, Radix Pulsatillae 15-20 weight portion, Herba Portulacae 20-27 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15-20 weight portion, Herba Senecionis Scandentis 20-27 weight portion, Radix Ampelopsis 20-26 weight portion, Calculus Bovis 15-24 weight portion, Herba Eupatorii 20-27 weight portion, Cortex Magnoliae Officinalis 15-20 weight portion, Fructus Amomi Rotundus 15-25 weight portion, Fructus Aurantii Immaturus 18-24 weight portion, fevervine 15-24 weight portion, Poria 15-20 weight portion, Semen Coicis 15-18 weight portion, Caulis Clematidis Armandii 20-24 weight portion, Medulla Junci 15-26 weight portion, Rhizoma Cimicifugae 15-20 weight portion, Mirabilitum crystallina 14-18 weight portion, Folium Bambusae 20-28 weight portion, Herba Sonchi Arvensis 20-29 weight portion, suspension rod fiber crops 3-5 weight portion, pseudobulbus Calanthes fimbriatae 4-5 weight portion, Herba Peperomiae Dindygulensis 15-20 weight portion, Radix Ilicis Asprellae 20-25 weight portion, Herba salviniae natantis 20-25 weight portion, Herba pterocephali 2-3 weight portion, Herba Sedi Multicaulis 15-20 weight portion and Herba Phaenospermatis globosae 18-23 weight portion.
4. the Chinese medicine preparation according to any one of claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Flos Lonicerae 20 weight portion, Fructus Forsythiae 18 weight portion, Folium Isatidis 13 weight portion, Flos Chrysanthemi Indici 20 weight portion, Rhizoma Fagopyri Dibotryis 13 weight portion, Semen Oroxyli 14 weight portion, the Radix Pulsatillae 12 weight portion, Herba Portulacae 17 weight portion, Pseudobulbus Cremastrae Seu Pleiones 13 weight portion, Herba Senecionis Scandentis 18 weight portion, Radix Ampelopsis 17 weight portion, Calculus Bovis 14 weight portion, Herba Eupatorii 16 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Fructus Amomi Rotundus 14 weight portion, Fructus Aurantii Immaturus 15 weight portion, fevervine 12 weight portion, Poria 13 weight portion, Semen Coicis 12 weight portion, Caulis Clematidis Armandii 18 weight portion, Medulla Junci 13 weight portion, Rhizoma Cimicifugae 12 weight portion, Mirabilitum crystallina 12 weight portion, Folium Bambusae 17 weight portion, Herba Sonchi Arvensis 16 weight portion, suspension rod fiber crops 6 weight portions, pseudobulbus Calanthes fimbriatae 6 weight portion, Herba Peperomiae Dindygulensis 12 weight portion, Radix Ilicis Asprellae 18 weight portion, Herba salviniae natantis 17 weight portion, Herba pterocephali 4 weight portion, Herba Sedi Multicaulis 12 weight portion and Herba Phaenospermatis globosae 15 weight portion.
5. the Chinese medicine preparation according to any one of Claims 1-4, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Flos Lonicerae 25 weight portion, Fructus Forsythiae 20 weight portion, Folium Isatidis 15 weight portion, Flos Chrysanthemi Indici 24 weight portion, Rhizoma Fagopyri Dibotryis 15 weight portion, Semen Oroxyli 15 weight portion, the Radix Pulsatillae 15 weight portion, Herba Portulacae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 15 weight portion, Herba Senecionis Scandentis 20 weight portion, Radix Ampelopsis 20 weight portion, Calculus Bovis 15 weight portion, Herba Eupatorii 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Fructus Amomi Rotundus 15 weight portion, Fructus Aurantii Immaturus 18 weight portion, fevervine 15 weight portion, Poria 15 weight portion, Semen Coicis 15 weight portion, Caulis Clematidis Armandii 20 weight portion, Medulla Junci 15 weight portion, Rhizoma Cimicifugae 15 weight portion, Mirabilitum crystallina 14 weight portion, Folium Bambusae 20 weight portion, Herba Sonchi Arvensis 20 weight portion, suspension rod fiber crops 3 weight portions, pseudobulbus Calanthes fimbriatae 4 weight portion, Herba Peperomiae Dindygulensis 15 weight portion, Radix Ilicis Asprellae 20 weight portion, Herba salviniae natantis 20 weight portion, Herba pterocephali 2 weight portion, Herba Sedi Multicaulis 15 weight portion and Herba Phaenospermatis globosae 18 weight portion.
6. the Chinese medicine preparation according to any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:
The first step, by Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Flos Chrysanthemi Indici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 60% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.22;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 60% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 10 ~ 20 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described oral solutions.
7. the Chinese medicine preparation according to any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is buccal tablet, and its preparation method comprises the following steps:
The first step, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones and Herba Senecionis Scandentis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 80% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci and Rhizoma Cimicifugae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 62 DEG C ~ 72 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.02 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain buccal tablet.
8. a preparation method for the Chinese medicine preparation described in any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:
The first step, by Flos Lonicerae, Fructus Forsythiae, Folium Isatidis and Flos Chrysanthemi Indici mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 60% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.21 ~ 1.22;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 60% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 10 ~ 20 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described oral solutions.
9. a preparation method for the Chinese medicine preparation described in any one of claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is buccal tablet, and its preparation method comprises the following steps:
The first step, Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Semen Oroxyli, the Radix Pulsatillae, Herba Portulacae, Pseudobulbus Cremastrae Seu Pleiones and Herba Senecionis Scandentis are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 80% ~ 90% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 80% ~ 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix Ampelopsis, Calculus Bovis, Herba Eupatorii, Cortex Magnoliae Officinalis, Fructus Amomi Rotundus, Fructus Aurantii Immaturus, fevervine, Poria, Semen Coicis, Caulis Clematidis Armandii, Medulla Junci and Rhizoma Cimicifugae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 62 DEG C ~ 72 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.02 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain buccal tablet.
10. the Chinese medicine preparation as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine preparation is: film coated tablet, sugar coated tablet, hard capsule, soft capsule, buccal tablet, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, powder, solution, sublimed preparation, suppository, plaster, syrup, injection, powder.
CN201410583368.5A 2014-10-27 2014-10-27 Traditional Chinese medicine preparation for treating toxin type recurrent oral ulcer during external infection and preparation method of traditional Chinese medicine preparation Pending CN104274763A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104688629A (en) * 2015-03-31 2015-06-10 周冠旻 Mouthwash for preventing oral ulcer inflammation
CN105148078A (en) * 2015-09-30 2015-12-16 卞文青 Medicinal preparation used for treating oral ulcers
CN106036862A (en) * 2016-06-22 2016-10-26 蚌埠市老顽童食品厂 Fructus aurantii immaturus buccal tablets
CN106491885A (en) * 2016-11-29 2017-03-15 广西大学 A kind of spray for treating oral ulcer
JP7462783B2 (en) 2020-03-03 2024-04-05 チー リウ Medical Use of Anemoside B4 in the Treatment of Oral Ulcers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225169A (en) * 2011-06-20 2011-10-26 山东大学 Traditional Chinese preparation for treating dental ulcer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225169A (en) * 2011-06-20 2011-10-26 山东大学 Traditional Chinese preparation for treating dental ulcer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104688629A (en) * 2015-03-31 2015-06-10 周冠旻 Mouthwash for preventing oral ulcer inflammation
CN105148078A (en) * 2015-09-30 2015-12-16 卞文青 Medicinal preparation used for treating oral ulcers
CN106036862A (en) * 2016-06-22 2016-10-26 蚌埠市老顽童食品厂 Fructus aurantii immaturus buccal tablets
CN106491885A (en) * 2016-11-29 2017-03-15 广西大学 A kind of spray for treating oral ulcer
JP7462783B2 (en) 2020-03-03 2024-04-05 チー リウ Medical Use of Anemoside B4 in the Treatment of Oral Ulcers

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Application publication date: 20150114