CN1125599A - Composition of external-use medicine for improving skin and gynecology and its manufacture method - Google Patents

Abstract

The exterior-use medicine for curing dermatosis and gynopathy, such as vaginitis, cervicitis, pruritus vulvae, leukorrhagia, eczema, beriberi, gonorrhoea and pointed condyloma with distinct curative effect features that it is existing medicine improved by use of alkaline substance to regulate its pH value to 7.6-10 for higher effectiveness. One of the medicines is prepared from 7 raw materials such as flavescent sophora root, chinaberry bark, dittany bark, benzyl alcohol, menthol, essence, etc.

Description

Improvement skin, gynecological external use medicine, wherein a kind of compositions and method for making

The present invention relates to pharmaceutical product, specifically is a kind of improvement topical drug for the treatment of skin, gynaecopathia.

Vulvitis, ulcer, vaginitis, cervicitis and condyloma acuminatum, gonorrhea eczema, tinea pediss etc. are commonly encountered diseases, sickness rate is high.After the morbidity, affected part is scratched where it itches, and itches pain unbearably, uneasy in either sitting or lying.Tcm clinical practice treatment to above-mentioned gynecological, cutaneous diseases, except that Chinese herbal medicine for oral administration, also select for use Chinese medicines such as Fructus Cnidii, Radix Sophorae Flavescentis, dried Alumen, Pericarpium Zanthoxyli to fry in shallow oil usually to smoke after the soup and wash affected part, or various sterilization deinsectization itching relieving Chinese medicine made washing liquid or unguentum or mist agent by certain technology, use with convenient, for example CN1047206A disclosed " manufacture method that pruritus is clean " is to make tincture with 13 flavor Chinese medicines such as Radix Sophorae Flavescentis, Fructus Cnidii behind dipping; CN1048323A disclosed " preventing and treating the preparation method of acquired immune deficiency syndrome (AIDS), sexually transmitted disease (STD) washing liquid " is solution to be poured in the solution that is dissolved with benzoic acid etc. with ten Six-element Chinese medicines such as the Radix Astragali, Radix Sophorae Flavescentis, Fructus Cnidii to mix after extracting; CN1072599A disclosed " a kind of clean cloudy Chinese medicine preparation and vagina-cleaning wet tissue " also is to get with getting filtrate adjust pH 6-7 after the 12 flavor herbal medicine immersion decocting in water extractions such as Fructus Cnidii, Radix Sophorae Flavescentis; CN1092977A disclosed " Jietai lotion and preparation technology thereof " concentrates back ethanol extraction, reuse 10%NaOH adjust pH to 6.5～7.5 with 14 flavor Chinese medicine decocting in water such as Rhizoma Smilacis Glabrae, Fructus Cnidii, Radix Sophorae Flavescentis.Above-mentioned patent application public technology and emerge product FUYINJIE and JIEERYIN etc., owing to adopt Chinese medicine is main and specific aim plus-minus medicine, to bacillary, mycotic, trichomonal vaginitis, gynecological, cutaneous diseases such as vulvitis, cervicitis etc. and gonorrhea, condyloma acuminatum, eczema, tinea pedis have better therapeutic effect.But above-mentioned medicament all is neutrality or meta-acid meta-alkalescence, and promptly pH value is generally in 6-7.5 scopes.Introduce according to " practical gynecology " (Shandong science tech publishing house version in 1979): " the vaginitis exudate is acid (pH=5) ", and " cervical mucus is secreted by cervix gland, react acid " (P599 page or leaf); Cause mycete colpitic " Candida albicans is suitable for growth most in pH value is 5.5 vaginal environment " (P164 page or leaf); " variation of vagina acid-base value directly influences trichomonal growth and breeding.Optimum pH value is 5.5-6.0.The pH value liter reaches trichomonal breeding in 7.5 o'clock and also is suppressed fully " (P165 page or leaf); Cultivate gonorrhea bacterium " pH value of culture medium should be 7.5 " (P210 page or leaf).Obviously, the growth and breeding environment that dermatosis, especially gynecological pathogenic bacteria are suited is a slant acidity, thereby very easily recurrence after the simple neutral slant acidity external medication remission, and particularly the not enough person of administration time is more obvious.

At multiple vaginitis, morbid leukorrhea, too quickly sour potassium also commonly used or acid solution demibain or liquid filling vaginas such as lactic acid or boric acid; Or with 2-3% soda liquid rinsing vulva treatment colpitis mycotica, or directly shampoo affected part with alkaline soap.One of its purpose is exactly by changing the pH value of affected part, various pathogen growth and breeding in the environment of peracid or mistake alkali being suppressed.But the flushing of simple acidity or alkalies only can the respite symptom, can not tackle the problem at its root.

The objective of the invention is to improve all kinds of vaginitiss of known treatment women, morbid leukorrhea and sexually transmitted disease (STD), eczema, dermopathic medicine for external use such as tinea pedis, especially Chinese medicine class, medicament after the improvement can also change the environment of affected part when having Pesticidal and sterilizing, make it to be not suitable for disease worm growth and breeding.The present invention also aims to provide a kind of new pharmaceutical composition with above characteristic.

The scheme that the object of the invention realizes, be to all kinds of vaginitiss of known treatment women, leukorrhagia disease and sexually transmitted disease (STD), eczema, dermopathic aqueous medicine for external use such as tinea pedis, especially the aqueous medicine for external use made of master such as Chinese medicine is improved, and is about to medicinal liquid and regulates pH value to 7.6-10 scope with alkaline matter, makes medicinal liquid be alkalescence.

Above-mentioned known be the main aqueous medicine for external use made from Chinese medicine, comprise publication or commercially available folk prescription or compound preparation on the public publication, and make spray, napkin, the aqueous raw material of unguentum and stype with these folk prescriptions or herbal mixture.Corresponding, the alkaline aqueous medicine after the present invention's improvement also can be done raw material and further be processed into dosage forms such as spray, napkin, unguentum or stype.

The alkaline matter that the present invention regulates pH value comprises chemical products, as NaHCO3, and NaOH, KOH, CaOH; Or comprise alkaline soil plant or its side-product such as plant ash.

Alkalescent medicine after the present invention's improvement, in the effect of Pesticidal and sterilizing effective ingredient, in the alkalescent medicine and the acidity of pars affecta skin, mucosa and secretions, make affected part be alkaline environment, thereby the growth and breeding that effectively suppresses pathogen and polypide, the Pesticidal and sterilizing effect of raising medicine.

Further realize the scheme of one of the object of the invention, be to provide a kind of new gynopathic alkalescent medicine compositions that is primarily aimed to comprise (weight): Radix Sophorae Flavescentis 8.31%～19.38%, Cortex Meliae 22.15%～33.22%, Radix Urenae Lobatae 22.15%～33.22%, Cortex Dictamni 22.15%～33.22%, benzyl alcohol 2.22%～3.32%, Mentholum 0.055%～0.069%, essence 0.22%～0.33%, pH value transfers to 7.6～10, preferably pH8.5～9.5 scopes.

This new alkalescent medicine preparation technology may further comprise the steps:

A. Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Meliae, Radix Urenae Lobatae soak the straight fire decoction in back with boiling water, get filtrate;

B. add benzyl alcohol, essence, Mentholum in the filtrate and leave standstill after mixing thoroughly, get filtrate;

C. filtrate water or alkaline matter are regulated full dose medicinal liquid pH value 7.6～10.

Alkalescent medicine of the present invention has overcome the deficiencies in the prior art, and drug effect is improved greatly.The alkalescent medicine that newly provides with the present invention is an example, detects through Colleges Of Traditional Chinese Medicine Of Guangxi and identifies that this medicine killed Candida albicans, gonococcus and trichomonacide in five minutes and is 100%.Through the clinical verification of Guangxi province the People's Hospital, this medicine is to gynecological's all kinds of pudendal pruritus disease total effective rate more than 98%.

Below further provide specific embodiments of the invention.

The present invention improves the alkalescent medicine composite formula and prepared does not limit, but comprises the medicine for external use of known treatment gynaecopathia, dermatosis and sexually transmitted disease (STD), directly regulates pH value to alkalescence with alkaline matter in known medicine for external use.Below list the part instantiation:

1. the Yuantang Pharmaceutical Factory, Guangxi FUYINJIE of producing, main component comprises Folium Eucalypti Robustae, Fructus Cnidii, MANSHANXIANG, Herba Senecionis Scandentis, Cortex Phellodendri etc.Make raw material with this neutrality medicinal liquid that this factory produces,, promptly get and improve alkaline medicinal liquid with 20% sodium bicarbonate (NaHCO3) adjust pH to 8.7～9.5.Can improve the effect of former medicine FUYINJIE after the improvement.

2. Radix Sophorae Flavescentis 30 grams, Fructus Cnidii 15 grams, Herba Aristolochiae Mollissimae 15 restrain, Rhizoma Smilacis Glabrae 30 grams, Cortex Phellodendri 15 grams, withered all 9 grams, Realgar 9 grams.Transfer filtrate pH to 10 with NaOH after taking filtrate.This medicine especially has remarkable result to colpitis mycotica.

3. Radix Sophorae Flavescentis 30 restrains, Fructus Cnidii 30 grams, Cortex Dictamni 30 grams, Cortex Phellodendri 15 grams.Decoct, use clarification lime water adjust pH to 7.6 after the extraction filtrate.This is medicinal to come washout that trichomonal vaginitis is had produce effects.

4. Folium Isatidis 25 restrains, Flos Lonicerae 25 grams, and Cortex Phellodendri 56 grams, Herba Taraxaci 50 grams, Herba Violae 25 grams, Radix Sophorae Flavescentis 25 restrains, and Olibanum 5 grams soak medicine 5 grams, Radix Gentianae 5 grams, Herba Hedyotidis Diffusae 25 grams.Decoct, use KOH adjust pH to 8.5 after the extraction filtrate.This medicine has produce effects to vulvitis.

5. Rhizoma Coptidis 20 restrains, Mirabilitum crystallina 20 grams, Borneolum Syntheticum 20 grams, Oleum Ricini 20 grams, vaseline 40 grams.Be deployed into paste, add the mulberry ash again and regulate pH value to 9.5.This medicine is coated with outward has produce effects to eczema.

6. Fructus Cnidii 25 restrains, Fructus Zanthoxyli 15 grams, and withered all 20 grams, Radix Sophorae Flavescentis 30 grams, Cortex Phellodendri 20 grams, Radix Stemonae 20 restrains, living Folium Artemisiae Argyi 20 grams.Decoct, behind the extracting solution with 20% sodium bicarbonate adjust pH to 8.7.The outer wiping of this medicine has produce effects to vulval ulcer.

7. Flos Chrysanthemi 20 restrains, Herba Violae 20 grams, and Herba Scutellariae Barbatae 30 grams, Fructus Cnidii 30 grams, Radix Sophorae Flavescentis 30 grams, Cortex Phellodendri 15 restrains, Radix Stemonae 15 grams.Decoct, extract filtrate and use NaOH adjust pH to 8.0.This medicine washout has produce effects to senile vaginitis.

8. 20% Rhizoma Coptidis immersion is with NaOH adjust pH to 8.5.This medicine is evident in efficacy to trichomonal vaginitis.

9. improvement CN1048323A, CN1047206A, the disclosed medicament of CN1072599A and CN1092977A is regulated the medicinal liquid acid-base value to pH8-9.5 scope with NaHCO3 or NaOH or CaOH respectively.Basic agent after the improvement can further improve drug effect.

It is as follows to the invention provides a kind of new alkalescent medicine specific embodiment:

10. get Cortex Dictamni 1.0kg, Cortex Meliae 1.0kg, Radix Urenae Lobatae 1.0kg, Radix Sophorae Flavescentis 0.5kg adds boiling water 15kg, soaks 12 hours, and the straight fire of reuse decocted 8 hours, filtered.Get filtrate and be concentrated into 8000ml,, in solution, add the 100ml benzyl alcohol, left standstill 24 hours after Mentholum of 2.3 grams (using earlier dissolve with ethanol) and 10 gram essence stir, filter with 20% sodium bicarbonate adjust pH to 9.5; Get filtrate water and 20% sodium bicarbonate adjust pH to 9.5, and make the medicinal liquid full dose reach 10000ml; The medicinal liquid of producing gets finished product after canned, sterilization, check, packing.This medicine washout or external application or be coated with outward can be treated women mycete, infusorian, colpitis mycotica, cervicitis, ulcer sexual reproduction device inflammation; Pruritus vulvae, leucorrhoea grow in quantity; Eczema, tinea pedis; Disease such as gonorrhea, condyloma acuminatum.Also can do the prevention and health care drug use.

11. according to prescription and the compound method of embodiment 10, its difference is that compositions is to get: Cortex Dictamni 0.8kg, Cortex Meliae 0.8kg, Radix Urenae Lobatae 0.8kg, Radix Sophorae Flavescentis 0.3kg, benzyl alcohol 80ml, Mentholum 2 grams, essence 8 grams; PH value transfers to 9.0.

12. according to prescription and the compound method of embodiment 10, its difference is that compositions is to get: Cortex Dictamni 1.2kg, Cortex Meliae 1.2kg, Radix Urenae Lobatae 1.2kg, Radix Sophorae Flavescentis 0.3kg, benzyl alcohol 120ml, Mentholum 2.5 grams, essence 10 grams; PH value transfers to 8.5.

13. according to embodiment 10 methods and step, its difference is also to add in the compositions 0.5kg Fructus Cnidii.

Claims (6)

1. improve skin, gynecological external use medicine for one kind,, it is characterized in that medicinal liquid is regulated pH value to 7.6～10.0 with alkaline matter, make medicinal liquid be alkalescence by treatment skin, the single of gynecological or folk prescription or the compound recipe liquid that the multi-flavor medicine is formed; Or spray, napkin, unguentum or the stype further made with these alkaline medicinal liquids.

2. according to the described improvement skin of claim 1, gynecological external use medicine, it is characterized in that with NaHCO3 or NaOH or KOH or Ca (OH) 2 or plant ash adjusting medicinal liquid acid-base value.

3. according to the described improvement skin of claim 1, gynecological external use medicine, it is characterized in that medicinal liquid is regulated pH value in 8.5～9.5 scopes.

4. according to the described improvement skin of claim 1, gynecological external use medicine, it is characterized in that compositions comprises following component (weight): Radix Sophorae Flavescentis 8.31%～19.38%, Cortex Meliae 22.15%～33.22%, Radix Urenae Lobatae 22.15%～33.22%, Cortex Dictamni 22.15～33.22%, benzyl alcohol 2.22%～3.32%, Mentholum 0.055%～0.069%, essence 0.22%～0.33%, the medicinal liquid pH value transfers to 7.6～10 scopes.

5. according to the described improvement skin of claim 1, gynecological external use medicine, it is characterized in that compositions is made up of following component (weight): Radix Sophorae Flavescentis 13.84%, Cortex Meliae 27.68%, Radix Urenae Lobatae 27.68%, Cortex Dictamni 27.68%, benzyl alcohol 2.77%, Mentholum 0.06%, essence 0.28%, medicinal liquid is regulated pH value to 8.5～9.5 scopes with 20% sodium bicarbonate.

6. the preparation method of the described improvement skin of claim 4, gynecological external use medicine is characterized in that comprising following processing step:

A. Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Meliae, Radix Urenae Lobatae soak the straight fire decoction in back with boiling water, get filtrate;

B. add benzyl alcohol, essence, Mentholum in the filtrate and leave standstill after mixing thoroughly, get filtrate;

C. filtrate water and alkaline matter are regulated full dose medicinal liquid pH value.