CN1879831A - Bacteriostatic externally applied preparation for treating gynecological inflammation and method for preparing same - Google Patents
Bacteriostatic externally applied preparation for treating gynecological inflammation and method for preparing same Download PDFInfo
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Abstract
The invention relates to a Chinese pharmaceutical composition for treating gynaecologic inflammation and process for preparation, wherein the composition is prepared from flavescent sophora root, rhubarb horsetails, cnidium fruit, corktree bark, poria cocos, Chinese dittany bark, roor of sessile stemona, wild chrysanthemum flower, Senecio scandens, zanthoxylum piperitum, carpesium fruit, evodia rutaecarpa, cortex pseudolaricis, gentian root, black catechu, dahurian angelica root, broom cypress fruit, dried alum, borax, metronidazole and auxiliary materials.
Description
Technical field:
The present invention relates to a kind of external preparation and preparation method thereof, particularly a kind ofly be used for external preparation and preparation method thereof antibacterial and the treatment gynecological inflammation, belong to the technical field of inhibiting-bacteria preparation.
Background technology:
Vaginitis, cervicitis, pelvic inflammatory disease is women's a common disease, simultaneously, women's pudendum and vagina are because the cause specific on the physiological structure, female private part and vagina very easily infect staphylococcus aureus, Candida albicans and mycete, Pseudomonas aeruginosa and bacillus pyocyaneus, escherichia coli, yeast, infusorian etc., so vaginitis, cervicitis, pelvic inflammatory disease etc. are the FAQs of women's pudendum and vagina, prior art has other drugs such as adopting antibiotic and other dosage forms to the associated treatment of these problems, but the use antibiotic can be to liver, kidney and relevant organ have certain toxic and side effects, also can influence the normal profitable strain of vagina, thereby cause the destruction of and defence capability self-cleaning, also easily cause vagina vagina, urethra, the cross infection of anus.
At present, though the medicine of the antibacterial and gynecological's pudendum diseases such as treatment vaginitis, cervix uteri inflammation of vagina also occurred much being used for, but its dosage form is all very traditional, produce effects and effect are direct inadequately, the most drug effect is single, and external used medicine is many based on washing liquid, and curative effect is not very desirable, and still belong to new shape dosage form at present as the intravaginal medication gel of gynecological inflammation
Summary of the invention:
The objective of the invention is to: provide a kind of and do not add hormone and antibiotics, have no side effect, good effect, can be used for external preparation of antibacterial and treatment gynecological inflammation and preparation method thereof, to overcome the deficiencies in the prior art.
The present invention is achieved in that and is used for external preparation antibacterial and the treatment gynecological inflammation: it is to be made by following raw medicaments in portion by weight: 10～60 parts of Radix Sophorae Flavescentiss, 10～40 parts of Radix Et Rhizoma Rhei, 10～30 parts of Fructus Cnidiis, 10～30 parts of Cortex Phellodendris, 10～60 parts of Rhizoma Smilacis Glabraes, 10～30 parts of favus skins, 10～30 parts of the Radixs Stemonae, 10～30 parts of Flos Chrysanthemi Indicis, 10～30 parts of Herba Senecionis Scandentiss, 5～30 parts of Fructus Zanthoxylis, 5～20 parts of Fructus Carpesiis, 5～30 parts of Fructus Evodiaes, 5～30 parts of Cortex Pseudolariciss, 10～50 parts of Radix Gentianaes, 10～45 parts in catechu, 10～50 parts of the Radixs Angelicae Dahuricae, 10～50 parts of the Fructus Kochiae, 3～15 parts of dried Alumens, 3～15 parts of Boraxs, 3～15 parts of metronidazoles.
Above-mentioned be used for antibacterial with the treatment gynecological inflammation external preparation, be preferably by the crude drug of following weight and make: Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 20g, Rhizoma Smilacis Glabrae 20g, favus skin 30g, Radix Stemonae 20g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 20g, Fructus Carpesii 20g, Fructus Evodiae 20g, Cortex Pseudolaricis 20g, Radix Gentianae 30g, catechu 25g, Radix Angelicae Dahuricae 30g, Fructus Kochiae 30g, dried Alumen 10g, Borax 10g, metronidazole 10g.
Be used for antibacterial external preparation and can be prepared into gel, lotion, suppository with the treatment gynecological inflammation.
The above-mentioned antibacterial gel with the treatment gynecological inflammation that is used for is preparation like this: weighting raw materials material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 20g, Rhizoma Smilacis Glabrae 20g, favus skin 30g, Radix Stemonae 20g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 20g, Fructus Carpesii 20g, Fructus Evodiae 20g, Cortex Pseudolaricis 20g, Radix Gentianae 30g, catechu 25g, Radix Angelicae Dahuricae 30g, Fructus Kochiae 30g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 5cm, decocted 3 hours, for the second time add water and just flood medical material, decocted 2 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, above-mentioned clear paste was left standstill 24 hours, smoke supernatant, add water to 1500Kg and get dilute liquid medicine, get dilute liquid medicine 30% and add carbomer 10g, triethanolamine 8g be stirred to dissolve fully A liquid, get B liquid with an amount of dissolved hydrogen water sodium oxide 4g in addition, moor golden 2g with the propylene glycol dissolving mud of 50g and get C liquid, with B, C liquid slowly adds in the A liquid with the glycerol of 30g, stir D liquid, again with dried Alumen 10g, Borax 10g, metronidazole 10g dissolving back add stir in the residue dilute liquid medicine E liquid, D liquid and the merging of E liquid are stirred, fill promptly gets gel of the present invention.
The above-mentioned antibacterial washing liquid with the treatment gynecological inflammation that is used for prepares like this: weighting raw materials material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 30g, Rhizoma Smilacis Glabrae 60g, favus skin 30g, Radix Stemonae 30g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 30g, Fructus Carpesii 20g, Fructus Evodiae 30g, Cortex Pseudolaricis 30g, Radix Gentianae 50g, catechu 45g, Radix Angelicae Dahuricae 50g, Fructus Kochiae 50g, after eluriating fast, place in the multi-function extractor, add water infiltration, open chuck and be heated to boiling, decoct 3 times, for the first time add water and be higher than medical material 6cm, decocted 2 hours, for the second time add water and just flood medical material, decocted 1.5 hours, add water for the third time and just flood medical material, decocted 1 hour, merge 3 times decocting liquid, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, add benzoic acid 10g, clarifier, purified water gets dilute liquid medicine to 1500kg, again with dried Alumen 15g, Borax 15g, metronidazole 15g dissolving back adds in the dilute liquid medicine stirred 20 minutes, left standstill 24 hours, smoke supernatant, promptly get lotion of the present invention.
The above-mentioned antibacterial suppository with the treatment gynecological inflammation that is used for prepares like this: weighting raw materials material Radix Sophorae Flavescentis 10g, Radix Et Rhizoma Rhei 10g, Fructus Cnidii 10g, Cortex Phellodendri 10g, Rhizoma Smilacis Glabrae 10g, favus skin 10g, Radix Stemonae 10g, Flos Chrysanthemi Indici 10g, Herba Senecionis Scandentis 10g, Fructus Zanthoxyli 5g, Fructus Carpesii 5g, Fructus Evodiae 5g, Cortex Pseudolaricis 5g, Radix Gentianae 10g, catechu 10g, Radix Angelicae Dahuricae 10g, Fructus Kochiae 10g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 3cm, decocted 1 hour, for the second time add water and just flood medical material, decocted 1.5 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃; Other gets an amount of glycerin gelatine heating for dissolving in water-bath, treats to dissolve fully even back and adds above-mentioned clear paste, stir, and injection molding, cooling, the demoulding, packing, promptly.
According to Chinese medical theory, Radix Sophorae Flavescentis in the side has the effect of heat clearing away, dampness, parasite killing, is used for leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, external treatment trichomonal vaginitis; Cortex Phellodendri has heat clearing and damp drying, and pathogenic fire purging removes the effect of steaming, is used for leukorrhagia, pyretic stranguria, pruritus etc.; Radix Et Rhizoma Rhei, Fructus Cnidii, Rhizoma Smilacis Glabrae, favus skin, the Radix Stemonae, dried Alumen, Borax have heat-clearing and toxic substances removing, antiinflammatory dampness, anticorrosion convergence, antipruritic analgesic effect, can eliminate the inflammatory reaction of various pudendum illness, and reduce the drainage of secretions, make pudendum keep dry and comfortable comfortable environment; Flos Chrysanthemi Indici in the side: be the dry capitulum of feverfew Herba Dendranthematis indici, gas fragrance, bitter in the mouth, suffering are slightly cold, and return liver, heart channel, have the effect of heat-clearing and toxic substances removing; Herba Senecionis Scandentis: cold in nature for the aerial parts of feverfew Herba Senecionis Scandentis, bitter in the mouth has heat-clearing and toxic substances removing, antipruritic effect; Fructus Zanthoxyli: i.e. Pericarpium Zanthoxyli, acrid in the mouth, return spleen, stomach, kidney channel, have warming middle-JIAO to relieve pain, the effect of killing parasites for relieving itching is used for external treatment eczema pruritus; Fructus Carpesii: be the dry mature fruit of feverfew Radix Carpesii, gas is special, and bitter in the mouth, suffering are flat, return spleen, stomach warp, have the effect of killing insect and eliminating accumulation; Fructus Evodiae: for the rutaceae Fructus Evodiae with mellow fruit, gas fragrance is strong, acrid in the mouth is peppery and bitter, and warming spleen and stomach for dispelling cold is arranged, dissipating depression of QI analgesic effect; Cortex Pseudolaricis: be dry root bark or the near root bark of pinaceae plant golden larch, feeble QI, bitter in the mouth and puckery, suffering, temperature is returned lung, spleen channel, has parasite killing, antipruritic effect; Radix Gentianae: bitter in the mouth, cold, return liver, gallbladder, urinary bladder channel, heat clearing and damp drying has the puckery pain of pyretic stranguria that damp-heat in lower-JIAO causes, the effect of damp-heat vaginal discharge, pudendum pruritus due to damp pathogen; Catechu: function with promoting granulation and relieving pain, hemostasis, removing dampness; The Radix Angelicae Dahuricae: property and flavor of peppery and warm fragrance, row stomach, large intestine channel have the function of expelling pathogenic wind from the body surface, pain relieving, detumescence, dampness leukorrhagia stopping; The Fructus Kochiae: effect with dispelling wind for relieving itching, vulval eczema; Metronidazole: be white or milky crystalline flour end; Slightly smelly, the bitter saline taste of tool has the powerful infusorian effect of killing slightly, is the choice drug of treatment trichomonal vaginitis.
More than all medicine compatibilities; the effect of mutual aid sterilizing and itch-relieving, anti-inflammation hemostasia; can suppress the antibacterial that staphylococcus aureus, Candida albicans and mycete, Pseudomonas aeruginosa and bacillus pyocyaneus, yeast and anaerobe resistant etc. cause vulva rapidly; after can be used for vagina daily nursing and sexual life front and back, take a shower or swimming; sit the antibacterial and cleaning of vagina behind the public seat summer, also can be used for treating vaginitis, bacterial vaginitis, cervicitis, gynecopathy such as pelvic inflammatory pudendum disease.
Gel dosage form particularly of the present invention belongs to the novel dosage form of Amino-Cerv, directly feeds vagina through the specialized package administrator, has advantages such as produce effects is fast, long action time.
The present invention is through clinical use, and total effective rate can reach more than 98%, and vaginitis, bacterial vaginitis, cervicitis, gynecopathy such as pelvic inflammatory pudendum disease are had more satisfactory therapeutic effect.
Below be clinical brief summary of the present invention:
1, clinical data: treatment female vagina, cervicitis, pelvic inflammatory disease totally 87 examples, vaginitis 49 examples wherein, cervicitis 21 examples, pelvic inflammatory disease 17 examples, 18-25 year 19 examples, 26 years old-48 years old 53 examples, 49-60 year 15 examples.In 87 examples oldest 60 years old, minimum 19 years old, the course of disease was the longest 6 years, the shortest 1 month.
2, clinical symptoms: show as pruritus of vagina, burn feeling and pain, in activity, sexual intercourse and the postemphasis of urinating; Vaginal secretions increases, frowziness; Urine is on the point of, urgent micturition, dysurea, intravaginal bearing down, pelvic cavity discomfort and malaise; Leucorrhoea grow in quantity and unusual, menoxenia, infertile etc.
3, Therapeutic Method: external, gel, suppository every day 1～2 time, each, every 5g; Lotion is got an amount of with the dilution of eliminating cold for resuscitation water, fumigation and wash method or demibain, every day 1～2 time; 1～4 week was a course of treatment.
4, therapeutic effect: in 87 examples, 65 examples of fully recovering, produce effects 12 examples, effective 8 examples, invalid 2 examples (being old group).
5, treatment standard: the complete obiteration of recovery from illness-clinical symptoms, produce effects and effective-clinical symptoms have clear improvement, and invalid-clinical symptoms is not seen improvement.
6, total effective rate: 98%.
The specific embodiment:
Embodiments of the invention 1: weighting raw materials material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 20g, Rhizoma Smilacis Glabrae 20g, favus skin 30g, Radix Stemonae 20g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 20g, Fructus Carpesii 20g, Fructus Evodiae 20g, Cortex Pseudolaricis 20g, Radix Gentianae 30g, catechu 25g, Radix Angelicae Dahuricae 30g, Fructus Kochiae 30g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 5cm, decocted 3 hours, for the second time add water and just flood medical material, decocted 2 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, above-mentioned clear paste was left standstill 24 hours, smoke supernatant, add water to 1500Kg and get dilute liquid medicine, get dilute liquid medicine 30% and add carbomer 10g, triethanolamine 8g be stirred to dissolve fully A liquid, get B liquid with an amount of dissolved hydrogen water sodium oxide 4g in addition, moor golden 2g with the propylene glycol dissolving mud of 50g and get C liquid, with B, C liquid slowly adds in the A liquid with the glycerol of 30g, stir D liquid, again with dried Alumen 10g, Borax 10g, metronidazole 10g dissolving back add stir in the residue dilute liquid medicine E liquid, D liquid and the merging of E liquid are stirred, automatic filling machine is sterilized, the debugging loom must not be less than 96% of expression amount by every loading amount and mix up, with above-mentioned gel fill in plastic tube, spiral cover, labeling, packing promptly gets gel finished product of the present invention.This product external, every day 1～2 time, each one, every 5g sends into intravaginal by vaginal administration device.
Embodiments of the invention 2: take by weighing clean raw medicinal material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 30g, Rhizoma Smilacis Glabrae 60g, favus skin 30g, Radix Stemonae 30g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 30g, Fructus Carpesii 20g, Fructus Evodiae 30g, Cortex Pseudolaricis 30g, Radix Gentianae 50g, catechu 45g, Radix Angelicae Dahuricae 50g, Fructus Kochiae 50g, after eluriating fast, place in the multi-function extractor, add water infiltration, open chuck and be heated to boiling, decoct 3 times, for the first time add water and be higher than medical material 6cm, decocted 2 hours, for the second time add water and just flood medical material, decocted 1.5 hours, add water for the third time and just flood medical material, decocted 1 hour, merge 3 times decocting liquid, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, added benzoic acid 10g, clarifier, purified water gets dilute liquid medicine to 1500kg, again with dried Alumen 15g, Borax 15g, metronidazole 15g dissolving back adds in the dilute liquid medicine stirred 20 minutes, left standstill 24 hours, and smoked supernatant, promptly get lotion of the present invention.
Embodiments of the invention 3: weighting raw materials material Radix Sophorae Flavescentis 10g, Radix Et Rhizoma Rhei 10g, Fructus Cnidii 10g, Cortex Phellodendri 10g, Rhizoma Smilacis Glabrae 10g, favus skin 10g, Radix Stemonae 10g, Flos Chrysanthemi Indici 10g, Herba Senecionis Scandentis 10g, Fructus Zanthoxyli 5g, Fructus Carpesii 5g, Fructus Evodiae 5g, Cortex Pseudolaricis 5g, Radix Gentianae 10g, catechu 10g, Radix Angelicae Dahuricae 10g, Fructus Kochiae 10g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 3cm, decocted 1 hour, for the second time add water and just flood medical material, decocted 1.5 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃; Other gets an amount of glycerin gelatine heating for dissolving in water-bath, treats to dissolve fully even back and adds above-mentioned clear paste, stir, and injection molding, cooling, the demoulding, packing promptly gets suppository.
Claims (6)
1, a kind of be used for antibacterial with the treatment gynecological inflammation external preparation, it is characterized in that: said preparation is to be made by following raw medicaments in portion by weight: 10～60 parts of Radix Sophorae Flavescentiss, 10～40 parts of Radix Et Rhizoma Rhei, 10～30 parts of Fructus Cnidiis, 10～30 parts of Cortex Phellodendris, 10～60 parts of Rhizoma Smilacis Glabraes, 10～30 parts of favus skins, 10～30 parts of the Radixs Stemonae, 10～30 parts of Flos Chrysanthemi Indicis, 10～30 parts of Herba Senecionis Scandentiss, 5～30 parts of Fructus Zanthoxylis, 5～20 parts of Fructus Carpesiis, 5～30 parts of Fructus Evodiaes, 5～30 parts of Cortex Pseudolariciss, 10～50 parts of Radix Gentianaes, 10～45 parts in catechu, 10～50 parts of the Radixs Angelicae Dahuricae, 10～50 parts of the Fructus Kochiae, 3～15 parts of dried Alumens, 3～15 parts of Boraxs, 3～15 parts of metronidazoles.
2, according to claim 1 be used for antibacterial with the treatment gynecological inflammation external preparation, it is characterized in that: said preparation is to be made by the crude drug of following weight: Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 20g, Rhizoma Smilacis Glabrae 20g, favus skin 30g, Radix Stemonae 20g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 20g, Fructus Carpesii 20g, Fructus Evodiae 20g, Cortex Pseudolaricis 20g, Radix Gentianae 30g, catechu 25g, Radix Angelicae Dahuricae 30g, Fructus Kochiae 30g, dried Alumen 10g, Borax 10g, metronidazole 10g.
3, according to claim 1 or 2 described be used for antibacterial with the treatment gynecological inflammation external preparation, it is characterized in that: described preparation is gel, lotion, suppository.
4, according to the described preparation method that is used for the external preparation of antibacterial and treatment gynecological inflammation of claim 1, it is characterized in that: weighting raw materials material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 20g, Rhizoma Smilacis Glabrae 20g, favus skin 30g, Radix Stemonae 20g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 20g, Fructus Carpesii 20g, Fructus Evodiae 20g, Cortex Pseudolaricis 20g, Radix Gentianae 30g, catechu 25g, Radix Angelicae Dahuricae 30g, Fructus Kochiae 30g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 5cm, decocted 3 hours, for the second time add water and just flood medical material, decocted 2 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, above-mentioned clear paste was left standstill 24 hours, smoke supernatant, add water to 1500Kg and get dilute liquid medicine, get dilute liquid medicine 30% and add carbomer 10g, triethanolamine 8g be stirred to dissolve fully A liquid, get B liquid with an amount of dissolved hydrogen water sodium oxide 4g in addition, moor golden 2g with the propylene glycol dissolving mud of 50g and get C liquid, with B, C liquid slowly adds in the A liquid with the glycerol of 30g, stir D liquid, again with dried Alumen 10g, Borax 10g, metronidazole 10g dissolving back add stir in the residue dilute liquid medicine E liquid, D liquid and the merging of E liquid are stirred, fill promptly gets gel of the present invention.
5, the preparation method that is used for the external preparation of antibacterial and treatment gynecological inflammation as claimed in claim 1, it is characterized in that: weighting raw materials material Radix Sophorae Flavescentis 60g, Radix Et Rhizoma Rhei 40g, Fructus Cnidii 30g, Cortex Phellodendri 30g, Rhizoma Smilacis Glabrae 60g, favus skin 30g, Radix Stemonae 30g, Flos Chrysanthemi Indici 30g, Herba Senecionis Scandentis 30g, Fructus Zanthoxyli 30g, Fructus Carpesii 20g, Fructus Evodiae 30g, Cortex Pseudolaricis 30g, Radix Gentianae 50g, catechu 45g, Radix Angelicae Dahuricae 50g, Fructus Kochiae 50g, after eluriating fast, place in the multi-function extractor, add water infiltration, open chuck and be heated to boiling, decoct 3 times, for the first time add water and be higher than medical material 6cm, decocted 2 hours, for the second time add water and just flood medical material, decocted 1.5 hours, add water for the third time and just flood medical material, decocted 1 hour, merge 3 times decocting liquid, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃, add benzoic acid 10g, clarifier, purified water gets dilute liquid medicine to 1500kg, again with dried Alumen 15g, Borax 15g, metronidazole 15g dissolving back adds in the dilute liquid medicine stirred 20 minutes, left standstill 24 hours, smoke supernatant, promptly get lotion of the present invention.
6, the preparation method that is used for the external preparation of antibacterial and treatment gynecological inflammation as claimed in claim 1, it is characterized in that: weighting raw materials material Radix Sophorae Flavescentis 10g, Radix Et Rhizoma Rhei 10g, Fructus Cnidii 10g, Cortex Phellodendri 10g, Rhizoma Smilacis Glabrae 10g, favus skin 10g, Radix Stemonae 10g, Flos Chrysanthemi Indici 10g, Herba Senecionis Scandentis 10g, Fructus Zanthoxyli 5g, Fructus Carpesii 5g, Fructus Evodiae 5g, Cortex Pseudolaricis 5g, Radix Gentianae 10g, catechu 10g, Radix Angelicae Dahuricae 10g, Fructus Kochiae 10g, after eluriating fast, place and ooze jar interior a decoction 2 times, for the first time add water and be higher than medical material 3cm, decocted 1 hour, for the second time add water and just flood medical material, decocted 1.5 hours, collecting decoction, filter, the survey relative density was 1.02 clear paste when filtrate was concentrated into 60 ℃; Other gets an amount of glycerin gelatine heating for dissolving in water-bath, treats to dissolve fully even back and adds above-mentioned clear paste, stir, and injection molding, cooling, the demoulding, packing promptly gets suppository of the present invention.
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| CN101474284B (en) * | 2009-01-16 | 2011-11-16 | 重庆灵方生物技术有限公司 | External use medicament for treating fungal dermatopathy |
| CN102698167A (en) * | 2012-05-23 | 2012-10-03 | 李承平 | Medicine combination tablets for treating trichomonas vaginitis |
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| CN105998974A (en) * | 2016-06-28 | 2016-10-12 | 深圳市纯原上品文化传播有限公司 | Traditional Chinese medicine composition and gels for treating gynecologic inflammation and preparation method thereof |
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