CN107802825A - A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa - Google Patents
A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa Download PDFInfo
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- CN107802825A CN107802825A CN201711259979.4A CN201711259979A CN107802825A CN 107802825 A CN107802825 A CN 107802825A CN 201711259979 A CN201711259979 A CN 201711259979A CN 107802825 A CN107802825 A CN 107802825A
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- vaginal mucosa
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 102000008186 Collagen Human genes 0.000 claims abstract description 10
- 108010035532 Collagen Proteins 0.000 claims abstract description 10
- 229920001436 collagen Polymers 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 9
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- 235000011449 Rosa Nutrition 0.000 claims abstract description 9
- 229940041616 menthol Drugs 0.000 claims abstract description 9
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- 239000008213 purified water Substances 0.000 claims abstract description 8
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention provides a kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa, it is made up of the raw material of following weight ratio：Safranine flower extract, aloe vera extract, Radix Stemonae extract, shrubby sophora extract, common cnidium fruit P.E, borneol, menthol, Rosa Damascana, collagen, biologically active peptide, poly hexamethylene biguanide, carbomer, remaining be purified water；The product of the present invention enters after vagina, affected part can be diffused to rapidly, the living environment of harmful bacteria is destroyed, adjusts the colony balance and acid-base balance of intravaginal, repairs the vaginal mucosa of breakage, then go deep into vagina and progressively clear up the toxin and harmful bacteria being attached to inside vagina, the autoimmunity of vagina is gradually restored, for safeguarding the normal weakly acidic condition of vagina, recover vagina self-cleaning antibacterial ability, nourish lubricious, there is fabulous maintenance effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa.
Background technology
The vagina mucosa of female reproductive system, refer to the holding vaginal walls surface wettability of vaginal walls secretion, keep table
The mucus film layer of face vigor, women is due to a variety of causes, and vagina can be by pathogenic infection, or colony balance and soda acid because of vagina
Equilibrium problem causes vaginal environment to change, and causes colporrhagia or various gynaecological diseases, in terms of traditional Chinese medical science angle, bacterial vaginosis BV
Etiology and pathogenesis it is more because liver,spleen,kidney three is dirty and wind, cold, wet, hot heresy；The etiology and pathogenesis of trichomonas vaginitis is mainly because wet
Heat is pented up, caused by worm-eaten the moon；Monilial vaginitis etiology and pathogenesis it is more because it is wet it is turbid pent up, caused by infecting evil poison；Senile the moon
The scorching etiology and pathogenesis main mechanism in road be the deficiency of liver-yin and kidney-yin, damp invasion of lower energizer, and is mainly thought in doctor trained in Western medicine by viral or courses of infection institute
Cause, vaginitis causes to perplex to women's daily life, may result in infertile, serious influence life and health.
The content of the invention
According to above-mentioned elaboration, it is an object of the invention to provide a kind of Chinese medicine composition gel, for suppressing vaginal mucosa
Infection, have it is promoting blood circulation and removing blood stasis, the effect of anti-inflammation.
Technical scheme provided by the invention：A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa, is by following heavy
The raw material of amount ratio is made：
Safranine flower extract 1%~3%, aloe vera extract 3%~8%, Radix Stemonae extract 8%~13%, hardship
Conopsea extraction 15%~25%, common cnidium fruit P.E 8%~15%, borneol 1%~3%, menthol 1%~3%, Rosa Damascana
1%~3%, collagen 4%~6%, biologically active peptide 4%~6%, poly hexamethylene biguanide 0.01%~0.025%, card
Ripple nurse 1%~3%, remaining be purified water；
In above-mentioned technical proposal, safranine flower extract 1%, aloe vera extract 5%, Radix Stemonae extract 10%, hardship
Conopsea extraction 20%, common cnidium fruit P.E 10%, borneol 2%, menthol 2%, Rosa Damascana 2%, collagen 5%, biology
Active peptide 5%, poly hexamethylene biguanide 0.018%, carbomer 1%, remaining be purified water.
A kind of preparation method for the antibacterial Traditional Chinese medicine gel composition of vaginal mucosa provided by the invention is：Will be described heavy
Measure part raw material：Safranine flower extract, aloe vera extract, Radix Stemonae extract, shrubby sophora extract, common cnidium fruit P.E, with
The borneol of parts by weight, menthol, Rosa Damascana, collagen, biologically active peptide, poly hexamethylene biguanide, carbomer mixing, add
Enter purified water and mix gel.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the active ingredient of extraction.
For the present invention based on the pathogenesis to gynecological disease and treatment principle, compatibility is reasonable, science, is tested through a large amount of clinics
Card, without any toxicity and side effects, product of the invention enter after vagina, can diffuse to affected part rapidly, destroy the existence ring of harmful bacteria
Border, the colony balance and acid-base balance of intravaginal are adjusted, repair the vaginal mucosa of breakage, then go deep into vagina and progressively clear up attachment
Toxin and harmful bacteria inside vagina, make the autoimmunity of vagina gradually be restored, for safeguarding that vagina is normal
Weakly acidic condition, recover vagina self-cleaning antibacterial ability, nourishing is lubricious, there is fabulous maintenance effect.
Embodiment
Technical scheme is clearly and completely described below, it is clear that described embodiment is only this
Invention part of the embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art exist
The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
The compatibility of drugs of the present invention is reasonable, and the effect of its component is：
The effect of safflower, function of promoting blood circulation to disperse blood clots is strong, and the present invention utilizes safflower promoting blood circulation and removing blood stasis, swelling and pain relieving.
Aloe barbadensis Miller, nature and flavor：It is bitter, cold in nature, it is nontoxic, there is sterilization, fungi, mould, bacterium, disease can be killed
The germs such as poison, suppress and the development of eliminating pathogen is bred, it may have antiinflammatory action.
The tuber of stemona, it is sweet, bitter, slightly warm in nature, there is the work(of desinsection and delousion, can be combined with frutus cnidii, kuh-seng and control Trichomonas vaginalis.
Kuh-seng, bitter is cold in nature, has antibacterial, antiinflammatory action.
Frutus cnidii, acrid flavour, hardship are warm-natured；It is slightly poisonous.There are antimycotic, antifungi, removing toxic substances desinsection, eliminating dampness, the function of wind-dispelling.
Borneol, acrid flavour is cold in nature, there is heat-clearing and fire-dispersing, detumescence effect.
Menthol, as excitants, skin or mucous membrane are acted on, there is refrigerant itching-relieving action.
Rosa Damascana, there is the effect of antibacterial, anti-spasm, sterilization.
Collagen, it is similar to the structure of human body skin collagen, contain glycoprotein for non-soluble fiber shape, richness in molecule
Containing a large amount of amino acid and hydrophilic group, play a part of moisturizing.
Biologically active peptide, easily absorbed by human body body, improve immunity of organisms.
Polyhexamethylene guanide, there is broad-spectrum, can use at normal temperatures；It is long-term antibacterial, it is optimal bactericide.
Carbomer is the effect of thickening.
According to above-mentioned component and compatibility principle analysis, the present invention discloses following examples.
Embodiment：
Take：A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa, is to be made from the following raw materials in parts by weight：
Safranine flower extract 10g, aloe vera extract 50g, Radix Stemonae extract 100g, shrubby sophora extract 200g, snake
Machine tool extract 100g, Borneolum Syntheticum extract 120g, menthol 20g, Rosa Damascana 20g, collagen 50g, biologically active peptide
To 1000g, the last weight of mixture is 1000g for 50g, poly hexamethylene biguanide 0.18g, carbomer 10g plus purified water.
In use, Chinese medicine composition gel is injected intravaginal by patient.
To show the fungistatic effect of the present invention, the embodiment of the present invention does bacteriostatic test：
First, equipment
1st, test strain：Escherichia coli (8099), 9 generations of culture, Candida albicans (ATCC10231), culture 9 generations, golden yellow
Color staphylococcus (ATCC6538), cultivated for 9 generations, provided by Chinese DSMZ.
2nd, general English agar medium, sabouraud's agar, provided by Beijing road and bridge technology Co., Ltd.
3/0.03mol/L phosphate buffer solution (PBS)
4th, carrier：Filter paper (2.0cm × 3.0cm), sterile measuring pipette, sterilized petri dishes, sterile test tube, constant incubator
Deng
2nd, sample is the present embodiment 5g, is put into sterile mortar grinding, crushes, mixes, is put into sterilized petri dishes and is directly pressed down
Bacterium is tested.
3rd, method is according to GB15979-200《Disposable Sanitary Accessory sanitary standard》Appendix C 4,《Disinfection technology is advised
Model》2002 editions 2.1.8 test.
Bacteriostatic test is carrier test, and 20 DEG C ± 1 DEG C of test temperature, experiment is repeated 3 times.
4th, result
Under conditions of 20 DEG C ± 2 DEG C of test temperature, embodiment is to Escherichia coli, Candida albicans, Staphylococcus aureus
Bacterium inhibition.
The embodiment of the present invention is examined to the inhibition of staphylococcus aureus and is shown in Table 1；
The inhibition of the staphylococcus aureus of table 1
The embodiment of the present invention is examined for the inhibition of Candida albicans and is shown in Table 2.
The inhibition of the Candida albicans of table 2
The embodiment of the present invention is examined to the inhibition of Escherichia coli and is shown in Table 3；
The inhibition of the Escherichia coli of table 3
The conclusion of experiment, embodiment are reachable to Escherichia coli, Candida albicans, staphylococcus aureus inhibiting rate above
More than 90%.
Meanwhile to do bright Tests For Irritating Effects as follows for this hair embodiment：
First, material and method
Experimental animal provides Japan big ear various schools of thinkers rabbit 6 by Xi'an Jiaotong University Medical College's Experimental Animal Center, female, body
Weigh 2.0-2.5kg, primary animal, credit number：SCXK (Shan) 2014-003, feed bedding and padding source Xi'an Communications University doctor
Institute's Experimental Animal Center provides.
Animal room environmental：22-25 DEG C of temperature, relative humidity：45% -55%.
2nd, Tests For Irritating Effects method
1st, test basis《Disinfection technology standard》2002 editions 2.1.8 test.
2nd, tested material dosage：2g/ is only.
3rd, test method：6 big ear various schools of thinkers rabbits of estrus Japan are randomly divided into 2 groups, respectively tested material and control group,
Every group 3, supine is fixed during experiment, and tested material group Via vagina injection tested material, control group gives physiological saline, and animal faces upward
Sleeping fixed 4h, makes tested material fully be contacted with vaginal mucosa.After off-test, animal is put back in cage and raised, and animal is put to death after 24h
Vagina tissue is taken out, phenomena such as visually examining mucous membrane denaturation, secretion, the congestion of blood vessel, oedema, such as changes and does pathologic group
Knit to check.
3rd, result of the test, tested material group vaginal mucosa form is normal, no secretion, without congested, swelling, has no that mucous membrane becomes
Property.
4th, conclusion：Embodiment is 0 for rabbit vagina mucosa irritation reaction average score, according to《Disinfection technology standard》
Medial vagina mucosa irritation reacts pulvis standard, belongs to non-stimulated.
To show the clinical application effect of the present invention, the present invention proves through clinical and experimental study：To the composition of embodiment
Test effect is carried out through the crowd of age groups and different gynaecological diseases, through experiment, this product is for bacterial vaginitis, trichomonad
The vaginal diseases such as property vaginitis, monilial vaginitis, purulent vaginitis, colpitis simplex have good effect, such as
Using leucorrhea increasing preceding be present or have foul smell, vulva to have itch, scorching hot, the symptom such as vaginal relaxation, intercourse pain makes patient
Larger improvement is obtained with after 3-7 days.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (2)
- A kind of 1. Traditional Chinese medicine gel composition antibacterial for vaginal mucosa, it is characterised in that：It is by the raw material system of following weight ratio Into：Safranine flower extract 1%~3%, aloe vera extract 3%~8%, Radix Stemonae extract 8%~13%, kuh-seng carry Take thing 15%~25%, common cnidium fruit P.E 8%~15%, borneol 1%~3%, menthol 1%~3%, Rosa Damascana 1% ~3%, collagen 4%~6%, biologically active peptide 4%~6%, poly hexamethylene biguanide 0.01%~0.025%, card ripple Nurse 1%~3%, remaining be purified water；By the raw material：Safranine flower extract, aloe vera extract, Radix Stemonae extract, shrubby sophora extract, cnidium monnieri Seed extract, borneol, menthol, Rosa Damascana, collagen, biologically active peptide, poly hexamethylene biguanide, card with parts by weight Ripple nurse mixes, and adds purified water and mixes gel.
- A kind of 2. Traditional Chinese medicine gel composition antibacterial for vaginal mucosa according to claim 1, it is characterised in that：Be by The raw material of following weight ratio is made：Safranine flower extract 1%, aloe vera extract 5%, Radix Stemonae extract 10%, kuh-seng Extract 20%, common cnidium fruit P.E 10%, borneol 2%, menthol 2%, Rosa Damascana 2%, collagen 5%, biology are living Property peptide 5%, poly hexamethylene biguanide 0.018%, carbomer 1%, remaining be purified water.
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| CN111588783A (en) * | 2020-07-01 | 2020-08-28 | 北京心军生物科技股份有限公司 | Traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and preparation method thereof |
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| CN110339337A (en) * | 2018-04-02 | 2019-10-18 | 西安万和医药科技有限公司 | One kind taking off black, the gel combination of nourishing for vagina relaxation |
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