CN110464811A - A kind of gynaecology's foam antibacterial liquid and preparation method thereof - Google Patents
A kind of gynaecology's foam antibacterial liquid and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of gynaecology foam antibacterial liquid and preparation method thereof, gynaecology foam antibacterial liquid includes following raw materials: Cortex Phellodendri, frutus cnidii, the tuber of stemona, aloe frozen-dried powder, menthol, borneol, matrine, poly hexamethylene biguanide part, ethylparaben, glycerol, triethanolamine, purified water.The invention has the benefit that gynaecology of the present invention has effects that heat-clearing and damp-drying drug with Cortex Phellodendri contained in foam antibacterial liquid, frutus cnidii has effects that antiallergy is antimycotic, the tuber of stemona has effects that sterilization, aloe frozen-dried powder, which has, restores collagen, the effect of sterilization, matrine has heat-clearing, diuresis, the effect of bactericidal antiphlogistic, poly hexamethylene biguanide property is stablized, bactericidal effect is significant and lasting, each raw material organically combines performance synergistic effect, with sterilization, it is antibacterial, the effect of cleaning, gained gynaecology is set to can solve women privates itch with foam antibacterial liquid, the gynaecological problems such as peculiar smell, cleaning is reached to women privates, the effect of nursing.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of gynaecology's foam antibacterial liquid and preparation method thereof.
Background technique
The disease of female reproductive system is gynecological disease, including vulva disease, vaginal disease, uterine disease, fallopian tubal
Disease, disease of ovary etc..Gynecological disease is the common disease of women, frequently-occurring disease, but since many people should have gynecological disease shortage
Understanding, lack health care to body, various bad life habits etc., make physiological health go from bad to worse in addition, lead to some female
Property be eaten up with illness, obstinate, to normal life, work belt is come greatly inconvenient.
Gynaecologic washing lotion is a kind of common feminine care products, is for women to clean, eliminate bad smell, treatment gynaecology
Inflammation, to reach the washing lotion of the pathogenic microorganisms for killing private parts, disinfection.The type of gynaecologic washing lotion has very much, and many women are selecting
Oneself is not just often suitable for according to the product that brand or the fragrance oneself liked are chosen, and chosen in this way when purchase
Product.Inappropriate washing product is used for a long time in people, may kill " healthy bodyguard "-Bacillus acidi lactici of intravaginal, changes
The microenvironment of intravaginal, and added with additive in existing many washing products, long-time service can destroy privates skin, in turn
Increase its risk for infecting gynecological disease.
Summary of the invention
The object of the present invention is to provide one kind to have restraining and sterilizing bacteria effect, and can improve gynaecology's foam of vaginal microenvironment
Antibacterial liquid and preparation method thereof.
A kind of gynaecology's foam antibacterial liquid, the raw material including following weight parts: 80-120 parts of Cortex Phellodendri, frutus cnidii 80-120
Part, 40-60 parts of the tuber of stemona, 8-12 parts of aloe frozen-dried powder, 8-12 parts of menthol, 3-6 parts of borneol, 1-3 parts of matrine, polyhexamethylene
0.4-0.8 parts of biguanides, 2-4 parts of ethylparaben, 8-12 parts of glycerol, 8-12 parts of triethanolamine, 640-760 parts of purified water.
Further, gynaecology foam antibacterial liquid, the raw material including following weight parts: 90-110 parts of Cortex Phellodendri, cnidium monnieri
90-110 parts sub-, 45-55 parts of the tuber of stemona, 9-11 parts of menthol, 4-5 parts of borneol, 1-2 parts of matrine, gathers 9-11 parts of aloe frozen-dried powder
0.5-0.7 parts of hexamethylene biguan-ide, 2.5-3.5 parts of ethylparaben, 9-11 parts of glycerol, 9-11 parts of triethanolamine, purified water
680-720 parts.
Further, gynaecology foam antibacterial liquid, the raw material including following weight parts: 100 parts of Cortex Phellodendri, frutus cnidii
100 parts, 50 parts of the tuber of stemona, 10 parts of aloe frozen-dried powder, 10 parts of menthol, 5 parts of borneol, 2 parts of matrine, poly hexamethylene biguanide 0.6
Part, 3 parts of ethylparaben, 10 parts of glycerol, 10 parts of triethanolamine, 700 parts of purified water.
Cortex Phellodendri is the dry bark of rutaceae wampee, bitter, cold in nature, the function with heat-clearing and damp-drying drug, purging intense heat, except steaming
Effect is commonly used to the symptoms such as treatment damp-heat dysentery, leukorrhagia pruritus vulvae, hectic fever due to yin labor heat, night sweat.Cortex Phellodendri is to staphylococcus aureus, white
Candida albicans and there is significant inhibiting effect to a variety of fungies, trichomonad.
Frutus cnidii alias cicely, is the dry mature fruit of umbelliferae cnidium monnieri, and warm-natured, bitter has temperature
The effect of kidney and enhancing body, eliminating dampness, wind-dispelling, desinsection.It is commonly used to treatment impotence, palace cold, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness lumbago shape.Cnidium monnieri
Son can improve sex hormone, play the role for the treatment of to male and female sterility；Frutus cnidii also has antianaphylactic effect, can treat
Anaphylactia.Furthermore frutus cnidii has eliminating the phlegm of relievining asthma, antimycotic, antiarrhythmic effect.
The tuber of stemona is the plant of Stemonaceae, sweet in flavor, has the function of moistening lung to lower qi cough-relieving, is commonly used to treatment cough, tuberculosis cough
It coughs, pertussis etc..Stemona alkaloids can reduce the excitability of animal breath maincenter, inhibit cough reflex and the work with antibechic
With；The tuber of stemona also has the function of antigen microorganism, to Escherichia coli, staphylococcus aureus, staphylococcus albus, bacillus anthracis
There is different degrees of inhibiting effect；It can be used to treat trichomonas vaginitis, pudendal pruritus.
Aloe frozen-dried powder can moisturizing, the partial moisture that loses in supplement skin, have the function of recovery collagen,
It is able to maintain skin smooth, soft and moist, high resilience.Have effects that anti-inflammation and sterilization, a variety of fungies, mould can be killed, has and inhibit
The effect of breeding is developed with eliminating pathogen.
Menthol is the derivative of natural plant extracts menthol, is a kind of freshener, can make product that need not contain second
Alcohol can possess ice-cold and fresh feeling, act on skin or mucous membrane, have the function of refrigerant antipruritic, analgesic antiphlogistic, to skin
Skin is mild, feels pure, and fragrance remaining time is long, and irritation is low.
Borneol is the crystallization obtained from the resin and volatile oil of kapur, has the function of anti-inflammatory, antibacterial, to golden yellow
Staphylococcus, Escherichia coli have inhibiting effect, can be reduced infection of the mushroom to skin surface wound, promote the healing of wound.This
Outside, borneol can increase granulation tissue structure and reepithelialization, repairs skin accessory organ and has stronger wound healing
Effect.
Matrine is raw made of being extracted the dry root of leguminous plant kuh-seng, plant, fruit through organic solvents such as ethyl alcohol
Alkaloids.Generally Banlangen, with matrine, oxymatrine concentration highest.Kuh-seng has as medicinal plant, main function
Heat-clearing, diuresis, desinsection, clearing damp and other effects；Bactericidal antiphlogistic effect, for certain skins, the fungal infection of vagina has different suppressions
Production is used, as matrine bolt can be used for treating colpomycosis.
Poly hexamethylene biguanide has the extremely strong ability for killing bacterium, and work fast, property are stable, can make at normal temperature
With long-term antibacterial without side-effects, absorption is usually in electronegative bacterium, virus, can enter cell membrane, and film lactones plastid is inhibited to close
At thallus apoptosis is caused, reach optimal bactericidal effect.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, stirring to being completely dissolved to obtain mixed liquor,
It is spare；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water to be decocted, be finished wait decoct, filtering removal filter residue, concentration filter
Ethyl alcohol is added into concentrate for liquid, is uniformly mixed, and stands filtering, obtains medicinal extract；Purified water is added into medicinal extract, stirring is mixed
It closes uniformly, standing is filtered to remove filter residue, and filtrate is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, obtain gynaecology foam antibacterial liquid.
Further, in step (1), the amount and matrine, menthol, ethylparaben, borneol total weight of ethyl alcohol used
Ratio be 4-5:3.
Further, it in step (2), takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water and carries out first time decoction, wait decoct
Finish, filters to obtain first time filtrate；Water be added into filtering gained filter residue carry out second and decoct, finished wait decoct, filter the
Secondary filtrate；Merge filtrate twice, is concentrated to give concentrate.
Further, the density of gained concentrate is 1.10g/ml-1.20g/ml.
Further, when decocting for the first time: the amount of water used and Cortex Phellodendri, frutus cnidii, tuber of stemona total weight ratio be 6-8:1,
The when a length of 1-3h decocted for the first time；Second when decocting: the amount of water used and the weight ratio of filter residue are 4-6:1, are decocted for second
The when a length of 1-2h boiled.
Further, in step (2), the weight ratio of amount and medicinal extract that purified water is added in medicinal extract is 10-20:1.
Further, in step (3), 5 are adjusted to pH, obtains gynaecology foam antibacterial liquid through microwave disinfection.
The invention has the benefit that gynaecology of the present invention has heat-clearing and damp-drying drug with Cortex Phellodendri contained in foam antibacterial liquid
Effect, frutus cnidii have effects that antiallergy is antimycotic, and the tuber of stemona has effects that sterilization, and aloe frozen-dried powder, which has, restores collagen egg
The effect of white, sterilization, matrine has effects that heat-clearing, diuresis, bactericidal antiphlogistic, and poly hexamethylene biguanide property is stable, sterilizes
Significant effect and persistently, each raw material organically combine performance synergistic effect, have effects that sterilization, it is antibacterial, clean, make institute
Gynaecology with foam antibacterial liquid can solve the gynaecological problems such as women privates itch, peculiar smell, cleaning, nursing are reached to women privates
Effect.
Because gynaecology of the present invention foam antibacterial liquid itself is in acidity, long-time service will not destroy women privates Tiny ecosystem
Environment, and women privates micro-ecological environment can be improved, its damaged cell is repaired, the health of privates, gynaecology of the present invention are protected
Any additive is not contained with foam antibacterial liquid, the micro-ecological environment that will not destroy women privates is used for a long time.
In addition, gynaecology of the present invention foam antibacterial liquid contains antianaphylaxis components, when use, is not likely to produce allergic phenomena,
If there is allergic phenomena, stopping using can restore, and will not injure skin.
Specific embodiment
Embodiment 1
A kind of gynaecology's foam antibacterial liquid, which is characterized in that the raw material including following weight parts: Cortex Phellodendri 80g, frutus cnidii
80g, tuber of stemona 40g, aloe frozen-dried powder 8g, menthol 8g, borneol 3g, matrine 1g, poly hexamethylene biguanide 0.4g, nipalgin second
Ester 2g, glycerol 8g, triethanolamine 8g, purified water 640g.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, stirring to being completely dissolved to obtain mixed liquor,
It is spare；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water to be decocted, be finished wait decoct, filtering removal filter residue, concentration filter
Ethyl alcohol is added into concentrate for liquid, is uniformly mixed, and stands filtering, obtains medicinal extract；Purified water is added into medicinal extract, stirring is mixed
It closes uniformly, standing is filtered to remove filter residue, and filtrate is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, obtain gynaecology foam antibacterial liquid.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in the present embodiment are as follows: 300,000 grades.
Embodiment 2
A kind of gynaecology's foam antibacterial liquid, which is characterized in that the raw material including following weight parts: Cortex Phellodendri 90g, frutus cnidii
90g, tuber of stemona 45g, aloe frozen-dried powder 9g, menthol 9g, borneol 4g, matrine 1g, poly hexamethylene biguanide 0.5g, nipalgin second
Ester 2.5g, glycerol 9g, triethanolamine 9g, purified water 680g.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, it is the amount of ethyl alcohol used and matrine, thin
Lotus brain, ethylparaben, borneol total weight ratio be 4:3, stirring is spare to being completely dissolved to obtain mixed liquor；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water and decocts 1h, the amount and Cortex Phellodendri, frutus cnidii, tuber of stemona gross weight of water used
The ratio of amount is 6:1, finishes wait decoct, filters to obtain first time filtrate, and water is added into filtering gained filter residue and continues to decoct 1h, used
The amount of water and the weight ratio of filter residue are 4:1, finish wait decoct, filter to obtain second of filtrate；Merge filtrate twice, is concentrated to give density
For the concentrate of 1.10g/ml, ethyl alcohol is added into concentrate, is uniformly mixed, stands filtering, obtains medicinal extract；Add into medicinal extract
Enter purified water, the amount of added purified water and the weight ratio of medicinal extract are 10:1, are uniformly mixed, and standing is filtered to remove filter residue, filters
Liquid is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, and it is antibacterial with foam to obtain the gynaecology through microwave disinfection
Liquid.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in the present embodiment are as follows: 300,000 grades.
Embodiment 3
A kind of gynaecology's foam antibacterial liquid, which is characterized in that the raw material including following weight parts: Cortex Phellodendri 100g, frutus cnidii
100g, tuber of stemona 50g, aloe frozen-dried powder 10g, menthol 10g, borneol 5g, matrine 2g, poly hexamethylene biguanide 0.6g, Ni Bo
Golden ethyl ester 3g, glycerol 10g, triethanolamine 10g, purified water 700g.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, it is the amount of ethyl alcohol used and matrine, thin
Lotus brain, ethylparaben, borneol total weight ratio be 4.5:3, stirring is spare to being completely dissolved to obtain mixed liquor；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water and decocts 1.5h, the amount and Cortex Phellodendri, frutus cnidii, the tuber of stemona of water used are total
The ratio of weight is 6.5:1, finishes wait decoct, filters to obtain first time filtrate, and water is added into filtering gained filter residue and continues to decoct
1.5h, the amount of water used and the weight ratio of filter residue are 4.5:1, finish wait decoct, filter to obtain second of filtrate；Merging is filtered twice
Liquid is concentrated to give the concentrate that density is 1.15g/ml, ethyl alcohol is added into concentrate, is uniformly mixed, stands filtering, must soak
Cream；Purified water is added into medicinal extract, the amount of added purified water and the weight ratio of medicinal extract are 15:1, are uniformly mixed, stand
Filter residue is filtered out, filtrate is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, and it is antibacterial with foam to obtain the gynaecology through microwave disinfection
Liquid.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in the present embodiment are as follows: 300,000 grades.
Embodiment 4
A kind of gynaecology's foam antibacterial liquid, which is characterized in that the raw material including following weight parts: Cortex Phellodendri 110g, frutus cnidii
110g, tuber of stemona 55g, aloe frozen-dried powder 11g, menthol 11g, borneol 5g, matrine 2g, poly hexamethylene biguanide 0.7g, Ni Bo
Golden ethyl ester 3.5g, glycerol 11g, triethanolamine 11g, purified water 720g.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, it is the amount of ethyl alcohol used and matrine, thin
Lotus brain, ethylparaben, borneol total weight ratio be 4.8:3, stirring is spare to being completely dissolved to obtain mixed liquor；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water and decocts 2h, the amount and Cortex Phellodendri, frutus cnidii, tuber of stemona gross weight of water used
The ratio of amount is 7:1, finishes wait decoct, filters to obtain first time filtrate, and water is added into filtering gained filter residue and continues to decoct 1.5h, institute
Weight ratio with the amount of water and filter residue is 5:1, is finished wait decoct, and second of filtrate is filtered to obtain；Merge filtrate twice, is concentrated to give close
Degree is the concentrate of 1.16g/ml, and ethyl alcohol is added into concentrate, is uniformly mixed, and stands filtering, obtains medicinal extract；Into medicinal extract
Purified water is added, the amount of added purified water and the weight ratio of medicinal extract are 18:1, are uniformly mixed, and standing is filtered to remove filter residue,
Filtrate is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, and it is antibacterial with foam to obtain the gynaecology through microwave disinfection
Liquid.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in the present embodiment are as follows: 300,000 grades.
Embodiment 5
A kind of gynaecology's foam antibacterial liquid, which is characterized in that the raw material including following weight parts: Cortex Phellodendri 120g, frutus cnidii
120g, tuber of stemona 60g, aloe frozen-dried powder 12g, menthol 12g, borneol 6g, matrine 3g, poly hexamethylene biguanide 0.8g, Ni Bo
Golden ethyl ester 4g, glycerol 12g, triethanolamine 12g, purified water 760g.
The preparation method of gynaecology foam antibacterial liquid, comprising the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, it is the amount of ethyl alcohol used and matrine, thin
Lotus brain, ethylparaben, borneol total weight ratio be 5:3, stirring is spare to being completely dissolved to obtain mixed liquor；
(2) it takes Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water and decocts 3h, the amount and Cortex Phellodendri, frutus cnidii, tuber of stemona gross weight of water used
The ratio of amount is 8:1, finishes wait decoct, filters to obtain first time filtrate, and water is added into filtering gained filter residue and continues to decoct 2h, used
The amount of water and the weight ratio of filter residue are 6:1, finish wait decoct, filter to obtain second of filtrate；Merge filtrate twice, is concentrated to give density
For the concentrate of 1.20g/ml, ethyl alcohol is added into concentrate, is uniformly mixed, stands filtering, obtains medicinal extract；Add into medicinal extract
Enter purified water, the amount of added purified water and the weight ratio of medicinal extract are 20:1, are uniformly mixed, and standing is filtered to remove filter residue, filters
Liquid is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, sweet
Oil, purified water, are mixed evenly, and it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, and it is antibacterial with foam to obtain the gynaecology through microwave disinfection
Liquid.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in the present embodiment are as follows: 300,000 grades.
Comparative example 1
The foam antibacterial liquid of gynaecology described in comparative example 1, contained raw material do not include poly hexamethylene biguanide, remaining raw material and system
Preparation Method is same as Example 3.
Comparative example 2
The foam antibacterial liquid of gynaecology described in comparative example 2, contained raw material do not include aloe frozen-dried powder, remaining raw material and preparation side
Method is same as Example 3.
Comparative example 3
The foam antibacterial liquid of gynaecology described in comparative example 3, contained raw material do not include matrine and the tuber of stemona, remaining raw material and preparation
Method is same as Example 3.
The production plant area cleanliness of the foam antibacterial liquid of gynaecology described in comparative example 1-3 are as follows: 300,000 grades.
Gynaecology described in 1-5 of the embodiment of the present invention and comparative example 1-3 with foam antibacterial liquid antibacterial aspect performance study one,
Bacteriostatic test
1, test equipment
(1) test strain: Escherichia coli, the staphylococcus aureus, Candida albicans in 6 generations of culture, by Chinese industrial
Microbiological Culture Collection administrative center provides；
(2) sample: gynaecology's foam antibacterial liquid described in 1-5 of the embodiment of the present invention and comparative example 1-3；
(3) nutrient agar: sabouraud's agar is provided by Beijing road and bridge technology Co., Ltd；
(4) 0.03mol/L phosphate buffer solution；
(5) sterile measuring pipette, sterilized petri dishes, test tube, constant incubator；
2, the method for inspection
(1) it is carried out according to GB15979-2002 " Disposable Sanitary Accessory sanitary standard "；
(2) bacteriostatic test is suspension test, and test temperature is 20 ± 1 DEG C, when test a length of 20min, test is in triplicate
It averages.
3, inspection body: Traditional Chinese Medicine Research Institute, Shanxi Province edible cosmetic product examines firm center, inspection result such as 1 institute of table
Show:
Table 1
| Escherichia coli bacteriostasis rate | Staphylococcus aureus | Candida albicans | |
| Embodiment 1 | 96% | 96% | 98% |
| Embodiment 2 | 98% | 96% | 99% |
| Embodiment 3 | 96% | 98% | 97% |
| Embodiment 4 | 96% | 97% | 99% |
| Embodiment 5 | 98% | 96% | 97% |
| Comparative example 1 | 76% | 81% | 79% |
| Comparative example 2 | 81% | 80% | 83% |
| Comparative example 3 | 69% | 71% | 68% |
As can be seen from Table 1: gynaecology of the present invention is with foam antibacterial liquid to Escherichia coli, staphylococcus aureus, white
The bacteriostasis rate of color candida albicans reaches 95% or more, has good fungistatic effect；And gynaecology described in comparative example 1-3 is antibacterial with foam
Liquid is relatively low to the bacteriostasis rate of Escherichia coli, staphylococcus aureus, Candida albicans.Gynaecology's foam i.e. of the present invention
The bacteriostasis property of antibacterial liquid is the effect of mutually collaboration between each raw material.
Two, antimicrobial stability is tested
1, test equipment
(1) test strain: Escherichia coli, the staphylococcus aureus, Candida albicans in 7 generations of culture, by Chinese industrial
Microbiological Culture Collection administrative center provides；
(2) sample: gynaecology's foam antibacterial liquid described in 1-5 of the embodiment of the present invention and comparative example 1-3；
(3) nutrient agar: sabouraud's agar is provided by Beijing road and bridge technology Co., Ltd；
(4) 0.03mol/L phosphate buffer solution；
(5) sterile measuring pipette, sterilized petri dishes, test tube, constant incubator (303-3 type), constant temperature and humidity incubator (HPX-
250B)；
2, the method for inspection
(1) it is carried out according to GB15979-2002 " Disposable Sanitary Accessory sanitary standard "；
(2) bacteriostatic test is suspension test, and test temperature is 20 ± 1 DEG C, when test a length of 20min, test is in triplicate
It averages；
(3) stability conditions: for sample through 37 DEG C, relative humidity >=75% takes sample to be pressed down after saving three months
Bacterium test, test in triplicate, are averaged；
3, inspection body: Traditional Chinese Medicine Research Institute, Shanxi Province edible cosmetic product examines firm center, inspection result such as 2 institute of table
Show:
Table 2
Gynaecology's foam antibacterial liquid of the present invention is 37 DEG C in temperature as can be seen from Table 2, relative humidity >=75%
It is saved three months in environment, bactericidal property is substantially unchanged, and stability is relatively good；And gynaecology's foam described in comparative example 1-3
Pair antibacterial liquid is 37 DEG C in temperature, is saved three months in the environment of relative humidity >=75%, and bactericidal property decreases, i.e.,
Gynaecology described in ratio 1-3, since the synergistic effect between raw material reduces, leads to its bactericidal performance and steady with foam antibacterial liquid
It is qualitative to be affected.
Three, Tests For Irritating Effects
1, tested material: gynaecology of the present invention foam antibacterial liquid；
2, experimental animal: providing Japanese white big ear rabbit 6 by Xi'an Jiaotong University Medical College's experimental zoology center, female
Property, weight 2.0-2.5kg, primary animal, credit number: SCXK (Shan) 2014-003, feed padding source are same as above；
3, animal experiment environment: temperature: 22 DEG C -25 DEG C, relative humidity: 45%-55%, animal house credit number: SCXK
(Shan) 2014-002
4, inspection body: according to " disinfection technology standard ", Traditional Chinese Medicine Research Institute, Shanxi Province edible cosmetic product is examined in calibrating
The heart；
5, test method: 6 estrus Japan white big ear rabbits are lain on the back fixation, perineum and introitus are exposed.It will
The soft insertion vagina (4cm-5cm) of conduit, and 2mL tested material is slowly injected into syringe.Animal puts back to cage after the test
Interior raising puts to death phenomena such as animal takes out vagina tissue, examines the congestion of blood vessel, oedema afterwards for 24 hours, and does Histopathology inspection
It looks into.
6, it is observed that tested group of rabbit vagina mucous membrane form is normal, no secretion, no congested, swelling has no mucosal degeneration
Change, grade scale, woman of the present invention are reacted according to Ministry of Public Health's version " disinfection technology standard " medial vagina mucosal irritation in 2002
Rabbit vagina mucosal irritation is reacted with foam bacteriostatic agent by section belongs to nonirritant, i.e., gynaecology's foam bacteriostatic agent pair of the present invention
Vaginal mucosa is non-stimulated.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its details, it is all that there is technical solution identical or similar to the present application,
It is within the scope of the present invention.
Claims (10)
1. a kind of gynaecology foam antibacterial liquid, which is characterized in that the raw material including following weight parts: 80-120 parts of Cortex Phellodendri, cnidium monnieri
80-120 parts sub-, 40-60 parts of the tuber of stemona, 8-12 parts of menthol, 3-6 parts of borneol, 1-3 parts of matrine, gathers 8-12 parts of aloe frozen-dried powder
0.4-0.8 parts of hexamethylene biguan-ide, 2-4 parts of ethylparaben, 8-12 parts of glycerol, 8-12 parts of triethanolamine, purified water 640-760
Part.
2. a kind of gynaecology foam antibacterial liquid according to claim 1, which is characterized in that the raw material including following weight parts:
90-110 parts of Cortex Phellodendri, 90-110 parts of frutus cnidii, 45-55 parts of the tuber of stemona, 9-11 parts of aloe frozen-dried powder, 9-11 parts of menthol, borneol 4-5
Part, 1-2 parts of matrine, 0.5-0.7 parts of poly hexamethylene biguanide, 2.5-3.5 parts of ethylparaben, 9-11 parts of glycerol, three ethyl alcohol
9-11 parts of amine, 680-720 parts of purified water.
3. a kind of gynaecology foam antibacterial liquid according to claim 1, which is characterized in that the raw material including following weight parts:
100 parts of Cortex Phellodendri, 50 parts of the tuber of stemona, 10 parts of aloe frozen-dried powder, 10 parts of menthol, 5 parts of borneol, 2 parts of matrine, gathers 100 parts of frutus cnidii
0.6 part of hexamethylene biguan-ide, 3 parts of ethylparaben, 10 parts of glycerol, 10 parts of triethanolamine, 700 parts of purified water.
4. the preparation method of foam antibacterial liquid of gynaecology described in one of claim 1-3, which comprises the following steps:
(1) matrine, menthol, ethylparaben, borneol is taken to be added in ethyl alcohol, stirring is spare to being completely dissolved to obtain mixed liquor；
(2) it taking Cortex Phellodendri, frutus cnidii, the tuber of stemona to be added to the water to be decocted, be finished wait decoct, filtrate is concentrated in filtering removal filter residue, to
Ethyl alcohol is added in concentrate, is uniformly mixed, stands filtering, obtains medicinal extract；Purified water is added into medicinal extract, is stirred
Even, standing is filtered to remove filter residue, and filtrate is spare；
(3) mixed liquor and filtrate are mixed evenly, sequentially add aloe frozen-dried powder, poly hexamethylene biguanide, glycerol, pure
Change water, be mixed evenly, it is 5 that triethanolamine, which is added dropwise, and is adjusted to pH, obtains gynaecology foam antibacterial liquid.
5. the preparation method of gynaecology's foam antibacterial liquid according to claim 4, which is characterized in that in step (1), second used
The amount and matrine of alcohol, menthol, ethylparaben, borneol total weight ratio be 4-5:3.
6. the preparation method of gynaecology's foam antibacterial liquid according to claim 4, which is characterized in that in step (2), take Huang
Cypress, frutus cnidii, the tuber of stemona, which are added to the water, carries out first time decoction, finishes wait decoct, filters to obtain first time filtrate；To filtering gained filter
Water is added in slag and carries out second of decoction, is finished wait decoct, filters to obtain second of filtrate；Merge filtrate twice, is concentrated to give concentration
Object.
7. the preparation method of gynaecology's foam antibacterial liquid according to claim 6, which is characterized in that the density of gained concentrate
For 1.10g/ml-1.20g/ml.
8. the preparation method of gynaecology's foam antibacterial liquid according to claim 6, which is characterized in that when decocting for the first time: institute
Ratio with the amount of water and Cortex Phellodendri, frutus cnidii, tuber of stemona total weight is 6-8:1, the when a length of 1-3h decocted for the first time；Second of decoction
When: the amount of water used and the weight ratio of filter residue are 4-6:1, the when a length of 1-2h decocted for second.
9. the preparation method of gynaecology's foam antibacterial liquid according to claim 4, which is characterized in that in step (2), in medicinal extract
The weight ratio of amount and medicinal extract that purified water is added is 10-20:1.
10. the preparation method of gynaecology's foam antibacterial liquid according to claim 4, which is characterized in that in step (3), to pH
5 are adjusted to, obtains gynaecology foam antibacterial liquid through microwave disinfection.
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