CN114699456A - Antibacterial and disinfectant composition and application thereof - Google Patents

Antibacterial and disinfectant composition and application thereof Download PDF

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CN114699456A
CN114699456A CN202210276770.3A CN202210276770A CN114699456A CN 114699456 A CN114699456 A CN 114699456A CN 202210276770 A CN202210276770 A CN 202210276770A CN 114699456 A CN114699456 A CN 114699456A
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extract
parts
bacteriostatic
combination
disinfectant
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沙超
王秀兰
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Yantai Luliang New Material Technology Co ltd
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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Abstract

The invention relates to a bacteriostatic and disinfectant composition and application thereof, wherein the bacteriostatic and disinfectant composition comprises nano zinc oxide, a chemical disinfectant and a plant extract; the chemical disinfectant comprises any one or combination of at least two of polyhexamethylene guanidine, polyhexamethylene biguanide, benzalkonium bromide, chlorhexidine hydrochloride or chlorhexidine acetate; the plant extract comprises any one or a combination of at least two of cortex moutan extract, cortex Phellodendri extract, lignum Aquilariae Resinatum extract, flos Lonicerae extract, herba Dendrobii extract, Glycyrrhrizae radix extract, radix Isatidis extract, fructus forsythiae extract, rhizoma Bletillae extract, fructus crataegi extract, plumula Nelumbinis extract, folium Eriobotryae extract or Allium mongolicum extract. The antibacterial preparation prepared from the antibacterial and disinfectant composition provided by the invention has good smell, mildness and antibacterial and anti-inflammatory effects, can be used for treating slight gynecological inflammation, and has important application value.

Description

Antibacterial and disinfectant composition and application thereof
Technical Field
The invention belongs to the technical field of medicines, relates to a bacteriostatic and disinfectant composition and application thereof, and particularly relates to a bacteriostatic and disinfectant composition for relieving slight gynecological inflammation and application thereof.
Background
At present, when the female reproductive health problems are mostly developed to serious gynecological inflammation or cervical erosion and other problems, the female reproductive health problems are carried out in a mode that medical institutions such as clinics and hospitals assist in drug treatment, and for some diseases which cannot reach the treatment degree, light inflammation is easily ignored. Patients usually adopt ignorance or relieve symptoms by orally taking anti-inflammatory drugs, and drug resistance is easy to generate, so that the small problems repeatedly appear, troubles normal life and cannot fundamentally solve the problems. Along with the great improvement of living standard, the attention degree of people to healthy life is gradually increased, people begin to pay attention to the importance of antibacterial products in the aspect of daily life, and various antibacterial products appear in the market one after another and are well loved by consumers, so that the market prospect is wide.
For example, CN102258725A discloses a sophora alopecuroides vagina cleaning bacteriostatic lotion and a preparation method thereof, wherein the sophora alopecuroides vagina cleaning bacteriostatic lotion comprises the following components: cortex Phellodendri, cortex pseudolaricis, caulis Sargentodoxae, Scutellariae radix, radix et rhizoma Rhei, radix Stemonae, radix Angelicae sinensis, fructus Zanthoxyli, Mentholum, Borneolum Syntheticum, Tween-80, glycerol, herba Sophorae Alopecuroidis, distilled water, and ethanol. The sophora alopecuroide vagina-cleaning bacteriostatic lotion follows the traditional compatibility principle, mainly has the functions of clearing away heat and toxic materials, inhibiting bacteria and diminishing inflammation, eliminating dampness and relieving itching, promoting blood circulation to remove blood stasis, and removing putrefaction to promote tissue regeneration, can effectively inhibit the growth and reproduction functions of candida albicans, staphylococcus aureus and escherichia coli, and has the advantages of precise material selection, excellent preparation process and no adverse side effect.
CN106913602A discloses a blumea balsamifera gynecological lotion and a preparation method and application thereof. The blumea balsamifera gynecological lotion comprises the following components in percentage by weight: 0.02-2.0% of blumea balsamifera extract, 1-10% of surfactant, 5-15% of cosolvent and penetration enhancer, 0.2-2% of humectant, 0.02-0.4% of bacteriostatic agent, 0.02-0.5% of nutritional agent, 0.01-0.5% of pH regulator and 71.48-92.73% of sterile ultrapure water, wherein the cosolvent and the penetration enhancer are propylene glycol. The blumea balsamifera extract used in the blumea balsamifera gynecological lotion is a natural Chinese herbal medicine component, has the functions of bacteriostasis and inflammation diminishing, and has aromatic smell; the prepared blumea balsamifera gynecological lotion has clear appearance and stable property, has the effects of eliminating peculiar smell, inhibiting bacteria, diminishing inflammation, cooling and refreshing skin, and has important application value.
CN112121125A discloses a method for extracting bacteriostatic components from traditional Chinese medicines to prepare gynecological lotion, which comprises the following steps: firstly, weighing the components: weighing medicinal components, wherein the medicinal components comprise phellodendron, fructus kochiae, bamboo leaves, honeysuckle, folium artemisiae argyi, chloroacetidine acetate, purified water, ethanol, peppermint oil and clove oil; the gynecological lotion prepared by the method has more excellent bacteriostatic ability, can effectively treat vaginitis and other symptoms in gynecological diseases, has small irritation to skin, human vulva and vaginal mucosa, and is safe, mild and nontoxic.
At present, the anti (bacteriostatic) bacteria lotion products are various, and mainly comprise pure chemical preparations or Chinese herbal medicine mixed ethanol. The former has obvious antibacterial effect, but has strong irritation, is easy to cause adverse reactions such as allergy and the like, and can accumulate toxicity or generate drug resistance after long-term use; the latter is mild in nature, but the antibacterial effect is not long enough, and the product has obvious smell and is not favorable for transportation and storage.
Therefore, how to develop an antibacterial lotion with good antibacterial effect, mildness, no irritation, no obvious smell or good smell is a problem to be solved urgently by the technical personnel in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a bacteriostatic and disinfectant composition and application thereof, and particularly provides a bacteriostatic and disinfectant composition for relieving slight gynecological inflammation and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a bacteriostatic and disinfectant composition comprising nano zinc oxide, a chemical disinfectant and a plant extract.
The chemical disinfectant comprises any one or combination of at least two of polyhexamethylene guanidine, polyhexamethylene biguanide, benzalkonium bromide, chlorhexidine hydrochloride or chlorhexidine acetate, such as the combination of polyhexamethylene guanidine and polyhexamethylene biguanide, benzalkonium bromide and chlorhexidine hydrochloride, chlorhexidine hydrochloride and chlorhexidine acetate, and the like, and any other combination can be adopted.
The plant extract comprises any one or combination of at least two of cortex moutan extract, cortex phellodendri extract, lignum aquilariae resinatum extract, honeysuckle extract, dendrobium officinale extract, liquorice extract, isatis root extract, fructus forsythiae extract, bletilla striata extract, hawthorn extract, lotus plumule extract, loquat leaf extract or allium mongolicum regel extract, for example, the combination of cortex phellodendri extract and lignum aquilariae resinatum extract, the combination of liquorice extract and radix isatidis extract, the combination of dendrobium officinale extract and liquorice extract, and the like, and any other combination mode can be adopted.
The nano zinc oxide and the chemical disinfectant are creatively compounded for use, wherein the nano zinc oxide is mild and non-irritant, can inhibit common pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa which cause skin and mucous membrane infection for a long time (more than 24 hours), and can play a role in long-time bacteriostasis protection without a weak acid environment after being quickly antibacterial (the pH of the bacteriostasis lotion disclosed by the invention is about 7). According to the invention, the nano zinc oxide and the chemical disinfectant are compounded for use, so that a better antibacterial effect can be achieved compared with the single use, and the addition amount of the chemical disinfectant is reduced by adopting a compounding mode, so that the product mildness is improved. On the basis, the composition also contains plant extracts with antibacterial and anti-inflammatory effects, so that the antibacterial effect of the composition is further improved, and the effects of reducing irritation and improving smell are also achieved. The bacteriostatic preparation prepared from the bacteriostatic and disinfectant composition provided by the invention has no obvious smell, is mild and non-irritant, has a good bacteriostatic effect, can be used for relieving slight gynecological inflammation, and has an important application value.
Preferably, the bacteriostatic and disinfectant composition comprises 0.1-3 parts by weight of nano zinc oxide, 0.1-5 parts by weight of chemical disinfectant and 0.1-15 parts by weight of plant extract.
Specific examples of the above-mentioned 0.1 to 3 parts include 0.1 part, 0.3 part, 0.5 part, 0.7 part, 1 part, 1.3 part, 1.5 part, 1.7 part, 2 parts, 2.3 parts, 2.5 parts, 2.7 parts, 3 parts and the like.
Specific examples of the above 0.1 to 5 parts include 0.1 part, 0.3 part, 0.5 part, 0.7 part, 1 part, 1.3 part, 1.5 part, 1.7 part, 2 parts, 2.3 parts, 2.5 parts, 2.7 parts, 3 parts, 3.3 parts, 3.5 parts, 3.7 parts, 4 parts, 4.3 parts, 4.5 parts, 4.7 parts, 5 parts and the like.
Specific examples of the above-mentioned 0.1 to 15 parts include 0.1 part, 0.3 part, 0.5 part, 0.7 part, 1 part, 1.3 part, 1.5 part, 1.7 part, 2 parts, 2.3 parts, 2.5 parts, 2.7 parts, 3 parts, 3.3 parts, 3.5 parts, 3.7 parts, 4 parts, 4.3 parts, 4.5 parts, 4.7 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts and the like.
Preferably, the chemical disinfecting agent comprises polyhexamethylene guanidine and/or polyhexamethylene biguanide.
Since the chlorhexidine acetate and the chlorhexidine hydrochloride are acidic and can react with the nano zinc oxide, the bacteriostatic effect of the composition is reduced. Benzalkonium bromide, however, is relatively toxic, and therefore the chemical disinfectants used in the present invention are preferably polyhexamethylene guanidine and/or polyhexamethylene biguanide.
Preferably, the plant extracts include moutan bark extract, phellodendron bark extract and hawthorn fruit extract.
Hawthorn fruit: property and taste: sweet and sour, slightly warm and nontoxic. Meridian tropism: spleen, stomach and liver meridians. Has strong antibacterial effect on pathogenic bacteria such as dysentery bacillus, Staphylococcus aureus, Streptococcus B, Escherichia coli, Bacillus proteus, Bacillus anthracis, diphtheria bacillus, typhoid bacillus, Pseudomonas aeruginosa, etc. The phellodendron amurense is the dry bark of phellodendron amurense of Rutaceae, generally grows in Sichuan, Guizhou and other zones, has the main effects of clearing heat and drying dampness, purging fire and removing sores, has the functions of detoxifying and healing sores, has the antibacterial effect on common suppurative and bacterial vaginitis, has the auxiliary effect on treating pudendum itch, body night sweat, jaundice and dark urine caused by damp heat, can relieve spermatorrhea and spermatorrhea symptoms caused by yin deficiency and fire excess, and has the functions of reducing blood pressure and resisting oxidation in addition. Cortex moutan has strong antibacterial effect on pathogenic bacteria such as Escherichia coli, typhoid bacillus, Pseudomonas aeruginosa, staphylococcus, hemolytic streptococcus, etc. According to the invention, the hawthorn extract, the phellodendron extract and the moutan bark extract are compounded, and are matched with each other to realize synergistic interaction, so that the antibacterial and anti-inflammatory effects of the composition are further improved, the irritation of the product is reduced, and the smell of the product is improved.
Preferably, the plant extract comprises 1-5 parts of moutan bark extract, 1-10 parts of phellodendron bark extract and 1-5 parts of hawthorn fruit extract in parts by weight.
Specific examples of the above-mentioned 1 to 5 parts include 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like.
Specific examples of the above-mentioned 1 to 10 parts include 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts and the like.
In a second aspect, the invention provides the use of the bacteriostatic disinfectant composition according to the first aspect in preparing a bacteriostatic preparation, wherein the bacteriostatic preparation is in the form of any one of a solution, a gel, a suppository or a soap.
In a third aspect, the invention provides a bacteriostatic lotion comprising the bacteriostatic and disinfectant composition according to the first aspect, an additive and water.
Preferably, the antibacterial and disinfectant composition is contained in the antibacterial lotion in an amount of 0.1-10 wt%, such as 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc.
Preferably, the additive comprises any one or a combination of at least two of a thickening agent, an acid-base regulator, a humectant or a stabilizer, for example, a combination of a thickening agent and an acid-base regulator, a combination of a thickening agent and a humectant, a combination of a humectant and an acid-base regulator, or any other combination, preferably a combination of a thickening agent, an acid-base regulator, a humectant and a stabilizer.
Preferably, the additive comprises 0.1-4 parts of thickening agent, 0.1-0.8 part of acid-base regulator, 1-5 parts of humectant and 0.1-2 parts of stabilizer in parts by weight.
Specific examples of the above-mentioned 0.1 to 4 parts include 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 part, 1.4 part, 1.5 part, 1.7 part, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3 parts, 3.2 parts, 3.5 parts, 3.7 parts, 4 parts and the like.
Specific examples of the above-mentioned 0.1 to 0.8 parts include 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, and 0.8 part.
Specific examples of the above-mentioned 1 to 5 parts include 1 part, 1.2 parts, 1.4 parts, 1.5 parts, 1.7 parts, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3 parts, 3.2 parts, 3.5 parts, 3.7 parts, 4 parts, 4.2 parts, 4.5 parts, 4.7 parts, 5 parts and the like.
Specific values in the above-mentioned 0.1 to 2 parts are, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, 1.2 parts, 1.4 parts, 1.5 parts, 1.7 parts, 2 parts and the like.
Preferably, the thickener comprises any one or combination of at least two of hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium alginate, acrylate polymer, gelatin or corn starch, such as a combination of sodium alginate and acrylate polymer, a combination of gelatin and corn starch, a combination of hydroxypropyl methyl cellulose and polyvinylpyrrolidone, and the like, and any other combination can be adopted.
Preferably, the pH regulator includes any one or a combination of at least two of sodium hydroxide, potassium hydroxide, triethanolamine or glacial acetic acid, such as a combination of triethanolamine and glacial acetic acid, a combination of potassium hydroxide and triethanolamine, a combination of sodium hydroxide and potassium hydroxide, and the like, and any other combination can be adopted.
Preferably, the humectant includes any one or a combination of at least two of glycerin, ethylene glycol, propylene glycol, water-soluble vitamin E or 1, 3-butanediol, such as a combination of glycerin and ethylene glycol, a combination of propylene glycol and water-soluble vitamin E, a combination of ethylene glycol and propylene glycol, and the like, and any other combination can be used.
Preferably, the stabilizer comprises disodium EDTA.
The recitation of numerical ranges herein includes not only the above-recited values, but also any values between any of the above-recited numerical ranges not recited, and for brevity and clarity, is not intended to be exhaustive of the specific values encompassed within the range.
Compared with the prior art, the invention has the following beneficial effects:
firstly, the nano-zinc oxide and the chemical disinfectant are creatively compounded for use, wherein the nano-zinc oxide is mild and non-irritant, can inhibit common pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa which cause skin and mucous membrane infection for a long time (more than 24 hours), and can play a role in long-time bacteriostasis protection without a weak acid environment after being quickly antibacterial (the pH value of the bacteriostasis lotion is about 7). The nano zinc oxide and the chemical disinfectant are compounded for use, so that a better antibacterial effect can be achieved compared with the single use, the addition amount of the chemical disinfectant is reduced by adopting a compounding mode, and the mildness of a lotion product is improved. Among them, in the aspect of selecting the chemical disinfectant, the invention preferably compounds polyhexamethylene biguanide and/or polyhexamethylene guanidine with nano zinc oxide in consideration of the product safety and the property of nano zinc oxide. In addition, the hawthorn extract, the phellodendron extract and the moutan bark extract are compounded, and are matched with each other to realize synergistic interaction, so that the antibacterial and anti-inflammatory effects of the antibacterial lotion are further improved, the irritation of the antibacterial lotion is reduced, and the smell of the product is improved. The antibacterial lotion prepared from the antibacterial and disinfectant composition provided by the invention can play a good antibacterial and anti-inflammatory role without producing a weak acid environment, has good smell and mildness, can nourish and moisten sensitive and fragile skin, can be used for treating slight gynecological inflammation, and has an important application value.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples, comparative examples, application examples and comparative application examples relate to the following raw material information:
the preparation method of the nano zinc oxide dispersant (polyvinylpyrrolidone is used as the dispersant) comprises the following steps:
adding absolute ethyl alcohol into a round-bottom flask, heating to 50 ℃, adding Zn (Ac) under the condition of continuous stirring2·H2Reacting O, potassium hydroxide and polyvinylpyrrolidone at 50 ℃ for 2 hours to obtain a reaction solution. Wherein, the absolute ethyl alcohol and Zn (Ac)2·H2Zn (Ac) in O2In a mass ratio of 80:1, Zn (Ac)2·H2The molar ratio of O to potassium hydroxide is 1: 2; polyvinylpyrrolidone with Zn (Ac)2·H2Zn (Ac) in O2The mass ratio of (A) to (B) is 3: 1. And (3) carrying out rotary evaporation on the reaction liquid to remove ethanol in the reaction liquid, and concentrating to obtain the nano zinc oxide dispersing agent (the mass percentage of zinc oxide in the nano zinc oxide dispersing agent is about 12%, and the particle size of zinc oxide is 5-6 nm).
Cortex moutan extract is obtained from Guangdong Sinuoke Biotechnology, Inc., cortex Phellodendri extract is obtained from Guangdong Sinuoke Biotechnology, Inc., and fructus crataegi oil is obtained from Guangdong Sinuoke Biotechnology, Inc. The acrylate polymer is purchased from Guangdong Tiancigaoxin high-new materials GmbH, the polyhexamethylene biguanide (daily chemical grade) is purchased from Shandong Youso chemical technology GmbH, and the polyhexamethylene guanidine (daily chemical grade) is purchased from Shandong Youso chemical technology GmbH; polyvinylpyrrolidone (pharmaceutical grade) was purchased from Guangdong Yueembellishment, Inc.
Example 1
The embodiment provides an antibacterial and disinfectant composition which comprises, by weight, 1 part of a nano zinc oxide dispersant, 2 parts of polyhexamethylene biguanide, 2 parts of a tree peony bark extract, 2 parts of hawthorn distillate oil and 3 parts of a golden cypress extract.
The preparation method only needs simple physical mixing of the raw materials.
Example 2
The embodiment provides an antibacterial and disinfectant composition which comprises, by weight, 0.9 part of a nano zinc oxide dispersant, 2.5 parts of polyhexamethylene guanidine, 3 parts of a tree peony bark extract, 1 part of hawthorn distillate oil and 4 parts of a golden cypress extract.
The preparation method only needs simple physical mixing of the raw materials.
Example 3
The embodiment provides an antibacterial and disinfectant composition which comprises, by weight, 1.5 parts of a nano zinc oxide dispersant, 0.5 part of polyhexamethylene guanidine, 1 part of polyhexamethylene biguanide, 1 part of a tree peony bark extract, 2 parts of hawthorn distillate oil and 1 part of a golden cypress extract.
The preparation method only needs simple physical mixing of the raw materials.
Example 4
This example provides an antibacterial and disinfectant composition, which is different from example 1 only in that "2 parts of cortex moutan extract, 2 parts of hawthorn distillate oil, and 3 parts of cortex phellodendri extract" are replaced with "7 parts of a combination of cortex moutan extract and hawthorn distillate oil", wherein the mass ratio of cortex moutan extract to hawthorn distillate oil is 1:1, and other components and contents are unchanged, and the preparation method thereof is as in example 1.
Example 5
The embodiment provides an antibacterial and disinfectant composition, which is different from the composition in the embodiment 1 only in that the polyhexamethylene biguanide is replaced by 7 parts of a combination of a moutan bark extract and a phellodendron bark extract, wherein the mass ratio of the moutan bark extract to the phellodendron bark extract is 2:3, and other components and contents are not changed, and the preparation method of the composition is as shown in the embodiment 1.
Example 6
This example provides a bacteriostatic and disinfectant composition, which is different from example 1 only in that "2 parts of moutan bark extract, 2 parts of hawthorn distillate oil, and 3 parts of cortex phellodendri extract" are replaced with "7 parts of a combination of hawthorn distillate oil and cortex phellodendri extract", wherein the mass ratio of the hawthorn distillate oil to the cortex phellodendri extract is 2:3, and other components and contents are unchanged, and the preparation method thereof is as in example 1.
Example 7
This example provides a bacteriostatic and disinfectant composition, which is different from example 1 only in that "2 parts of moutan bark extract, 2 parts of hawthorn distillate oil, and 3 parts of phellodendron bark extract" are replaced with "7 parts of hawthorn distillate oil", and other components and contents are not changed, and the preparation method thereof is as in example 1.
Example 8
This example provides a bacteriostatic and disinfectant composition, which is different from example 1 only in that "2 parts of moutan bark extract, 2 parts of hawthorn distillate oil, and 3 parts of phellodendron bark extract" are replaced with "7 parts of phellodendron bark extract", and other components and contents are not changed, and the preparation method thereof is as in example 1.
Example 9
This example provides a bacteriostatic and disinfectant composition, which is different from example 1 only in that "2 parts of moutan bark extract, 2 parts of hawthorn distillate oil, and 3 parts of phellodendron bark extract" are replaced with "7 parts of peony extract", and other components and contents are not changed, and the preparation method thereof is as in example 1.
Example 10
This example provides a bacteriostatic and disinfectant composition, which is different from example 1 only in that "2 parts of polyhexamethylene biguanide" is replaced with "2 parts of chlorhexidine acetate", and other components and contents are not changed, and the preparation method thereof is as in example 1.
Comparative example 1
This comparative example provides a bacteriostatic disinfectant composition which differs from example 1 only in that 1 part of nano zinc oxide dispersant is absent, 0.12 part of polyhexamethylene biguanide is additionally added, and other components and contents are not changed. The preparation process is as in example 1.
Comparative example 2
This comparative example provides a bacteriostatic disinfectant composition which differs from example 1 only in the absence of "2 parts of polyhexamethylene biguanide", in the absence of water in a quantity complementary thereto, and in the absence of other components and in amounts which are not changed. The preparation process is as in example 1.
Comparative example 3
The comparative example provides an antibacterial and disinfectant composition, which is different from the composition in example 1 only in that tree peony bark extract, hawthorn distillate oil and golden cypress extract are lacked, the lacked amount is complemented with water, and other components and contents are not changed. The preparation process is as in example 1.
Application example 1
The application example provides an antibacterial lotion, which comprises, by mass, 3.2% of the antibacterial and disinfectant composition of example 1, 0.15% of an acrylate polymer (thickener), 0.1% of triethanolamine (acid-base regulator), 2% of glycerin (humectant), 0.3% of disodium EDTA (stabilizer), and the balance of water.
The preparation method only needs simple physical mixing of the raw materials.
Application example 2
The application example provides an antibacterial lotion which comprises, by mass, 3.2% of the antibacterial and disinfectant composition of example 2, 0.1% of an acrylate polymer (thickening agent), 0.15% of triethanolamine (acid-base regulator), and the balance of water.
The preparation process is as in application example 1.
Application example 3
The application example provides an antibacterial lotion which comprises, by mass, 3.2% of the antibacterial and disinfectant composition of example 3, 0.3% of sodium alginate (thickening agent), 0.1% of potassium hydroxide (acid-base regulator), 1% of ethylene glycol (humectant), and the balance of water.
The preparation process is as in application example 1.
Application examples 4 to 10
Application examples 4-10 provide seven bacteriostatic lotions which differ from application example 1 only in that the bacteriostatic disinfecting composition of example 1 was replaced with the equivalent amount of the bacteriostatic disinfecting composition of examples 4-10, respectively, and the other conditions were referenced to application example 1.
Comparative application examples 1 to 3
Comparative application examples 1-3 provide three bacteriostatic lotions which differ from application example 1 only in that the bacteriostatic disinfecting composition of example 1 was replaced with the equivalent amount of the bacteriostatic disinfecting composition of comparative examples 1-3, respectively, and the other conditions were as in application example 1.
Test example 1
Test of bacteriostatic Effect
And (3) detecting the inhibition effect of each group of samples on common pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa according to the test standard of 'disinfection technical specification' (the bacteriostasis test time is 24 h).
And (3) testing a sample: bacteriostatic lotions according to application examples 1-10 and comparative application examples 1-3 and two commercially available lotions. Equal volumes of each set of sample washes were taken separately for testing. The results of the bacteriostatic ratio (%) of each group are shown in Table 1.
TABLE 1
Figure BDA0003556058170000121
Figure BDA0003556058170000131
The results show that: the bacteriostatic lotion provided by each application example has a good bacteriostatic effect. The bacteriostatic rate of the bacteriostatic lotion of application examples 4-9 is slightly lower than that of application example 1, which shows that the bacteriostatic lotion is prepared by compounding the hawthorn extract, the phellodendron extract and the moutan bark extract, and the hawthorn extract, the phellodendron extract and the moutan bark extract are mutually matched and synergically enhanced, so that the bacteriostatic effect of the bacteriostatic lotion is further improved. The bacteriostatic rate of the bacteriostatic washing liquid in application example 10 is poorer than that in application example 1, because chlorhexidine acetate is acidic and can react with nano zinc oxide, so that the bacteriostatic effect of the bacteriostatic washing liquid is reduced. Compared with the bacteriostatic lotion of application examples 1-2, the bacteriostatic rate of the bacteriostatic lotion of application examples 1-2 is lower than that of application example 1, which shows that the bacteriostatic lotion can achieve better bacteriostatic effect by compounding the nano zinc oxide and the chemical disinfectant for use than by using the nano zinc oxide and the chemical disinfectant separately.
Test example 2
Safety test
Selecting 130 social volunteers meeting the requirements, wherein the social volunteers are 20-45 years old and randomly divided into 13 groups, and respectively trying the antibacterial lotion provided by application examples 1-10 and comparative application examples 1-3 according to the groups. 0.020-0.025mL of the test sample is respectively taken and put into a small chamber of a spot tester, and the contrast hole is not processed. The spot test device with the test substance is applied to the back or forearm of the subject with hypoallergenic tape, and is applied to the skin with palm pressure for 48 h. Skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque from the test article, respectively, according to the criteria of table 1.
TABLE 2
Figure BDA0003556058170000132
Figure BDA0003556058170000141
The results show that: the application examples 1-10 and the comparative application examples 1-3 are negative reactions, which shows that the safety of the antibacterial washing liquid related to the invention is guaranteed, and adverse reactions such as skin irritation, sensitization (except people who are easy to be allergic or people who are allergic to the antibacterial washing liquid) and the like can not be generated.
Test example 3
Crowd test
Selecting 75 female social volunteers aged 20-45 years and having inflammation (representing pudendum pruritus) on pudendum, randomly dividing the female social volunteers into 15 groups, respectively trying 5 female social volunteers with application examples 1-10, antibacterial lotion for comparing application examples 1-3 and two commercially available antibacterial lotions, cleaning the pudendum with the same amount of antibacterial lotion every night for 1 week (no other anti-inflammatory drugs are used during the test period), evaluating the odor, the mildness and the anti-inflammatory effect of the product after the test is finished, and adopting a scoring mode for evaluation, wherein all the groups are averagely listed in a table 3.
And 5, dividing: no obvious smell exists; the mildness is very good; after the test, inflammation disappears, and pruritus disappears.
2-4 min: has slight smell; the mildness is good; after the test, the inflammation and the pruritus are relieved.
1 minute: has obvious smell; the mildness is poor, and the irritation is good; inflammation did not improve after the test.
TABLE 3
Figure BDA0003556058170000142
Figure BDA0003556058170000151
The results show that: compared with the washing liquid sold in the market, the antibacterial washing liquid provided by the invention has excellent comprehensive performance in the aspects of smell, mildness and antibacterial and anti-inflammatory effects. From the results of application examples 1, 4-9 and comparative application example 3, the hawthorn extract, the phellodendron bark extract and the moutan bark extract are compounded and matched with each other to realize synergistic interaction, so that the irritation of a bacteriostatic product is reduced, the smell of the product is improved, and the bacteriostatic and anti-inflammatory effects of the bacteriostatic lotion are further improved. From the results of application example 1 and comparative application examples 1-2, the invention can achieve better bacteriostatic effect by compounding the nano zinc oxide and the chemical disinfectant compared with singly using the nano zinc oxide and the chemical disinfectant. And the addition amount of the chemical disinfectant is reduced by adopting a compounding mode, so that the mildness of the product is improved.
The applicant states that the invention is described by the above examples and application examples to describe a bacteriostatic and disinfectant composition and its application, but the invention is not limited to the above examples and application examples, that is, the invention is not meant to be implemented only by relying on the above examples and application examples. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

Claims (10)

1. A bacteriostatic and disinfectant composition is characterized by comprising nano zinc oxide, a chemical disinfectant and a plant extract;
the chemical disinfectant comprises any one or the combination of at least two of polyhexamethylene guanidine, polyhexamethylene biguanide, benzalkonium bromide, chlorhexidine hydrochloride or chlorhexidine acetate;
the plant extract comprises any one or a combination of at least two of cortex moutan extract, cortex Phellodendri extract, lignum Aquilariae Resinatum extract, flos Lonicerae extract, herba Dendrobii extract, Glycyrrhrizae radix extract, radix Isatidis extract, fructus forsythiae extract, rhizoma Bletillae extract, fructus crataegi extract, plumula Nelumbinis extract, folium Eriobotryae extract or Allium mongolicum extract.
2. A bacteriostatic and disinfectant composition according to claim 1, wherein said bacteriostatic and disinfectant composition comprises 0.1-3 parts by weight of nano zinc oxide, 0.1-5 parts by weight of chemical disinfectant and 0.1-15 parts by weight of plant extract.
3. A bacteriostatic disinfecting composition according to claim 1 or 2 wherein the chemical disinfectant comprises polyhexamethylene guanidine and/or polyhexamethylene biguanide.
4. A bacteriostatic and disinfecting composition according to any one of claims 1 to 3, wherein said plant extract comprises moutan bark extract, phellodendron bark extract and hawthorn fruit extract;
preferably, the plant extract comprises 1-5 parts of moutan bark extract, 1-10 parts of phellodendron bark extract and 1-5 parts of hawthorn fruit extract in parts by weight.
5. Use of the bacteriostatic and disinfectant composition according to any one of claims 1 to 4 in the preparation of a bacteriostatic preparation in the form of any one of a solution, a gel, a suppository or a soap.
6. Bacteriostatic lotion characterized in that the bacteriostatic lotion comprises the bacteriostatic and disinfectant composition as claimed in any one of claims 1-4, an additive and water.
7. The bacteriostatic lotion according to claim 6, wherein the mass percentage of the bacteriostatic and disinfectant composition in the bacteriostatic lotion is 0.1-10%.
8. A bacteriostatic lotion according to claim 6 or 7 wherein the additive comprises any one or a combination of at least two of a thickener, an acid-base modifier, a humectant or a stabilizer, preferably a combination of a thickener, an acid-base modifier, a humectant and a stabilizer.
9. The bacteriostatic lotion according to any one of claims 6 to 8, wherein the additive comprises 0.1 to 4 parts by weight of a thickener, 0.1 to 0.8 part by weight of an acid-base regulator, 1 to 5 parts by weight of a humectant and 0.1 to 2 parts by weight of a stabilizer.
10. The bacteriostatic lotion of claim 8 or 9, wherein the thickener comprises any one or a combination of at least two of hydroxyethyl cellulose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, sodium alginate, acrylate polymers, gelatin or corn starch;
preferably, the acid-base regulator comprises any one or a combination of at least two of sodium hydroxide, potassium hydroxide, triethanolamine or glacial acetic acid;
preferably, the humectant comprises any one or a combination of at least two of glycerin, ethylene glycol, propylene glycol, water-soluble vitamin E or 1, 3-butanediol;
preferably, the stabilizer comprises disodium EDTA.
CN202210276770.3A 2022-03-21 2022-03-21 Antibacterial and disinfectant composition and application thereof Pending CN114699456A (en)

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Application publication date: 20220705