CN114177123B - Fragrant Chinese herbal medicine toothpaste and preparation method thereof - Google Patents
Fragrant Chinese herbal medicine toothpaste and preparation method thereof Download PDFInfo
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- CN114177123B CN114177123B CN202210013323.9A CN202210013323A CN114177123B CN 114177123 B CN114177123 B CN 114177123B CN 202210013323 A CN202210013323 A CN 202210013323A CN 114177123 B CN114177123 B CN 114177123B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides an aromatic Chinese herbal medicine toothpaste and a preparation method thereof, wherein the Chinese herbal medicine toothpaste is prepared from the following components: 0.1 to 5 percent of eupatorium extract, 0.1 to 5 percent of paniculate swallowwort root extract, 0.1 to 5 percent of perilla stem extract, 5 to 25 percent of sorbitol, 1 to 10 percent of polyethylene glycol, 0.5 to 3 percent of sodium dodecyl sulfate, 0.1 to 2 percent of sodium lauroyl sarcosinate, 0.5 to 2 percent of sodium carboxymethylcellulose, 0.1 to 0.5 percent of saccharin sodium, 5 to 25 percent of silicon dioxide, 0.1 to 5 percent of calcium hydrophosphate, 0.01 to 0.1 percent of sodium benzoate, 0.1 to 2 percent of mint essence and the balance of water. The synergistic effect of herba Eupatorii extract, radix Cynanchi Paniculati extract and caulis Perillae extract can be used to exert dampness eliminating, antiinflammatory and analgesic effects. The Chinese herbal medicine toothpaste is safe to use, and the Chinese herbal medicine functional components of the toothpaste can inhibit oral pathogenic bacteria, prevent halitosis, refresh breath, diminish inflammation and relieve pain, thereby improving oral hygiene.
Description
Technical Field
The invention relates to the technical field of preparation of oral care products, in particular to aromatic Chinese herbal medicine toothpaste and a preparation method thereof.
Background
Currently, oral problems mainly include caries, tartar, plaque, gingival bleeding, dentin sensitivity, tooth whitening, breath, and the like. Oral problems not only affect the chewing of people, but also are related to diseases of the human body's own system, so people are more and more concerned about the plot and health of the oral cavity. The toothpaste is the most commonly used oral cavity cleaning product for people, and has the functions of cleaning teeth, freshening breath and the like. In order to improve the functionality of the toothpaste and solve various oral problems, chinese herbal medicine components are usually added into the toothpaste. For example, patent (application number 201811252783.7) is a traditional Chinese medicine toothpaste for removing necrotic tissue and promoting granulation, which is added with herba Cymbopogonis Citrari extract, herba Fritillariae Cirrhosae extract and herba abri extract, and has good inhibiting effect on various pathogenic bacteria by preventing canker sore caused by body injury due to excessive oxidation of active ingredients of herba Cymbopogonis, herba Fritillariae Cirrhosae and herba abri.
Herba Eupatorii has effects of eliminating dampness, activating spleen, stimulating appetite, relieving exterior syndrome, and relieving summer heat, and herba Eupatorii extract has aromatic smell, and contains various volatile oils such as coumaric acid, coumaric essence, thymoquinone, taraxasterol, etc. Can be used for treating damp obstruction, gastric fullness, vomiting, sweet and greasy mouth, halitosis, excessive saliva, summer-heat and dampness exterior syndrome, early stage of damp-heat, listlessness, chest distress, etc.
The paniculate swallowwort root has the functions of dispelling wind, eliminating dampness, relieving pain and relieving itching. Can be used for treating rheumatalgia, gastralgia distention, toothache, lumbago, traumatic injury, rubella, eczema, etc. The radix Cynanchi Paniculati extract contains various antibacterial and antiinflammatory components, and has analgesic and repercussive effects.
Perilla stem has effects of regulating qi-flowing, relieving pain, and preventing miscarriage. Can be used for treating chest distress, gastralgia, belch, emesis, and fetal movement. The perilla stem extract contains various natural anti-inflammatory components, can eliminate various pathogenic bacteria and viruses, and can reduce the occurrence of the phenomenon of brushing teeth and retching in the morning of pharyngitis patients.
Researches show that the eupatorium extract, the paniculate swallowwort root extract and the perilla stem extract have certain antibacterial effects, but the antibacterial effects are not obvious, and no report on traditional Chinese medicine toothpaste prepared from three traditional Chinese medicine combinations has been made at present.
Disclosure of Invention
In order to solve the problems, the invention aims to provide the aromatic Chinese herbal medicine toothpaste and the preparation method thereof.
In order to achieve the above object, the technical scheme of the present invention is as follows.
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 0.1 to 5 percent of eupatorium extract, 0.1 to 5 percent of paniculate swallowwort root extract, 0.1 to 5 percent of perilla stem extract, 5 to 25 percent of sorbitol, 1 to 10 percent of polyethylene glycol, 0.5 to 3 percent of sodium dodecyl sulfate, 0.1 to 2 percent of sodium lauroyl sarcosinate, 0.5 to 2 percent of sodium carboxymethylcellulose, 0.1 to 0.5 percent of saccharin sodium, 5 to 25 percent of silicon dioxide, 0.1 to 5 percent of calcium hydrophosphate, 0.01 to 0.1 percent of sodium benzoate, 0.1 to 2 percent of mint essence and the balance of water.
Further, the aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 5% of paniculate swallowwort root extract, 3% of perilla stem extract, 20% of sorbitol, 8% of polyethylene glycol, 1% of sodium dodecyl sulfate, 1% of sodium lauroyl sarcosinate, 0.5% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 5% of silicon dioxide, 2% of calcium hydrophosphate, 0.05% of sodium benzoate, 2% of mint essence and the balance of water.
The invention also provides a preparation method of the aromatic Chinese herbal medicine toothpaste, which comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C;
s2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol, saccharin sodium and sodium benzoate into the solution B, and uniformly mixing to obtain a component B;
s3, mixing and stirring the component A and the component B uniformly, then adding the solution A and the solution C, and continuing to stir uniformly to obtain paste;
and S4, grinding the paste of the step S3 uniformly, and then carrying out vacuum degassing to obtain the aromatic Chinese herbal medicine toothpaste.
In S4, the vacuum degassing is carried out under the vacuum degree of minus 0.15 to minus 0.09MPa for 10 to 30min.
In the Chinese herbal medicine formula, the Chinese herbal medicine extract consists of eupatorium extract, paniculate swallowwort root extract and perilla stem extract. Wherein the herba Eupatorii extract, radix Cynanchi Paniculati extract, and caulis Perillae extract are water extracts.
Eupatorium, pungent and flat; enter spleen, stomach and lung meridians. Herba Eupatorii extract has fragrant smell, has effects of eliminating dampness, activating spleen, stimulating appetite, relieving inflammation, and eliminating phlegm, and can remove oral bacteria.
Paniculate swallowwort root, radix Cynanchi Paniculati, pungent and warm; enter liver and stomach meridians. Radix Cynanchi Paniculati extract containing paeonol and having aromatic smell; also contains various antibacterial and antiinflammatory components, and has effects in dispelling pathogenic wind, eliminating dampness, relieving pain and detumescence.
Perilla stem, pungent and warm; enter lung and spleen meridians. The perilla stem extract contains various natural anti-inflammatory components, has the effects of regulating qi, relieving the middle warmer, promoting digestion, resolving phlegm and relieving pain, can eliminate various pathogenic bacteria and viruses, and can reduce the occurrence of the phenomenon of brushing teeth and retching in the morning of pharyngitis patients.
In the formula of the Chinese herbal medicine, eupatorium is taken as a monarch drug, and the Chinese herbal medicine has the effects of eliminating dampness, resisting inflammation and eliminating phlegm; the paniculate swallowwort root is taken as a ministerial drug, so that the effects of resolving dampness and resisting inflammation of the monarch drug are achieved, and the pain relieving effect can be exerted; the perilla stem is taken as an adjuvant drug to strengthen the pain relieving effect of the ministerial drug, and has the effects of regulating qi, relieving the middle warmer, promoting digestion and reducing phlegm; the medicines are combined to play the roles of resolving dampness, resisting inflammation and relieving pain.
Seen from the nature and taste of the traditional Chinese medicine, herba eupatorii, pungent and flat; enter spleen, stomach and lung meridians. Paniculate swallowwort root, radix Cynanchi Paniculati, pungent and warm; enter liver and stomach meridians. Perilla stem, pungent and warm; enter lung and spleen meridians. The pungent has the effects of dispersing and relieving exterior syndrome, is beneficial to dredging the gum, clearing cold phlegm coagulation and relieving toothache. However, dyspepsia, binge eating, too much greasy, sweet and thick-flavored food will increase viscera burden, and spleen, stomach, liver and gallbladder in middle energizer are most easily damaged, especially spleen is most prone to be affected by dampness, spleen cannot be normally transported and transformed, and thus the organism is stopped in water dampness. Herba Eupatorii, radix Cynanchi Paniculati and caulis Perillae are mutually matched to regulate spleen, stomach, liver and lung channels, and improve body dampness eliminating capability.
In the auxiliary component of the invention, sorbitol can be used as a humectant or can be used together with saccharin sodium as a sweetener. Sorbitol has good hygroscopicity, can effectively maintain the moisture of the toothpaste paste, and ensures the stability of the paste, especially the stability at low temperature, while maintaining the fluidity of the paste.
Polyethylene glycol can be used as a solvent, a humectant and a solubilizer, and can be mutually matched with sorbitol to improve the stability of the toothpaste under the condition of keeping the moisture of the toothpaste.
Calcium hydrogen phosphate is used together with silica as a friction agent. The silicon dioxide has good thixotropic property, can strengthen the adhesive force of paste on the toothbrush together with calcium hydrophosphate, avoids the problem that the paste falls off, and can reduce the abrasion to teeth while wiping off the tartar on the surface of the teeth.
Sodium dodecyl sulfate is an anionic surfactant which can be used together with sodium lauroyl sarcosinate as a foaming agent, has washing, emulsifying, penetrating, solubilizing and excellent foamability, and has fine, durable and abundant foam.
Sodium carboxymethyl cellulose, CMC, is hygroscopic and can be used as a thickener for toothpaste pastes.
The sodium benzoate is used as a preservative, so that the aim of inhibiting and killing bacteria can be fulfilled.
Peppermint essence is an aroma-imparting agent and can also be used to solubilize Eupatorium extract.
The invention has the beneficial effects that:
1. the Chinese herbal medicine toothpaste disclosed by the invention is safe to use, and the Chinese herbal medicine functional components of the toothpaste can inhibit oral pathogenic bacteria, prevent bad breath, refresh breath, diminish inflammation and relieve pain, so that the oral hygiene is improved.
2. In the Chinese herbal medicine toothpaste, the eupatorium extract and the paniculate swallowwort root extract synergistically exert the effect of eliminating dampness; the paniculate swallowwort root extract and the perilla stem extract synergistically exert the analgesic effect; the herba Eupatorii extract, radix Cynanchi Paniculati extract and caulis Perillae extract have antiinflammatory and antiinflammatory effects; the three synergistic effects exert the effects of resolving dampness, resisting inflammation and relieving pain together.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials are commercially available unless otherwise specified.
Example 1
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 5% of paniculate swallowwort root extract, 3% of perilla stem extract, 20% of sorbitol, 8% of polyethylene glycol, 1% of sodium dodecyl sulfate, 1% of sodium lauroyl sarcosinate, 0.5% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 5% of silicon dioxide, 2% of calcium hydrophosphate, 0.05% of sodium benzoate, 2% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C; the extracts should be sufficiently soluble between the phases.
S2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.096 MPa for 30min to obtain paste, and packaging to obtain aromatic Chinese herbal toothpaste.
Example 2
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 3% of eupatorium extract, 3% of paniculate swallowwort root extract, 2% of perilla stem extract, 25% of sorbitol, 5% of polyethylene glycol, 2% of sodium dodecyl sulfate, 0.1% of sodium lauroyl sarcosinate, 1% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 10% of silicon dioxide, 5% of calcium hydrophosphate, 0.1% of sodium benzoate, 2% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C; the extracts should be sufficiently soluble between the phases.
S2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.09 MPa for 30min to obtain paste, and packaging to obtain the aromatic Chinese herbal medicine toothpaste.
Example 3
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 3% of eupatorium extract, 1% of paniculate swallowwort root extract, 1% of perilla stem extract, 15% of sorbitol, 3% of polyethylene glycol, 1% of sodium dodecyl sulfate, 1% of sodium lauroyl sarcosinate, 1% of sodium carboxymethyl cellulose, 0.3% of saccharin sodium, 15% of silicon dioxide, 0.5% of calcium hydrophosphate, 0.05% of sodium benzoate, 1% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C; the extracts should be sufficiently soluble between the phases.
S2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing under vacuum degree of-0.10 MPa, stirring for 25min, making into paste, and packaging to obtain aromatic Chinese herbal toothpaste.
Example 4
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 2% of paniculate swallowwort root extract, 2% of perilla stem extract, 10% of sorbitol, 10% of polyethylene glycol, 3% of sodium dodecyl sulfate, 0.5% of sodium lauroyl sarcosinate, 2% of sodium carboxymethyl cellulose, 0.5% of saccharin sodium, 25% of silicon dioxide, 0.1% of calcium hydrophosphate, 0.05% of sodium benzoate, 1% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C; the extracts should be sufficiently soluble between the phases.
S2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing under vacuum degree of-0.15 MPa, stirring for 10min, making into paste, and packaging to obtain aromatic Chinese herbal toothpaste.
Example 5
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 1% of eupatorium extract, 1% of paniculate swallowwort root extract, 2% of perilla stem extract, 5% of sorbitol, 1% of polyethylene glycol, 2% of sodium dodecyl sulfate, 0.5% of sodium lauroyl sarcosinate, 1% of sodium carboxymethyl cellulose, 0.2% of saccharin sodium, 20% of silicon dioxide, 0.1% of calcium hydrophosphate, 0.05% of sodium benzoate, 0.5% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C; the extracts should be sufficiently soluble between the phases.
S2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.12 MPa for 15min to obtain paste, and packaging to obtain the aromatic Chinese herbal medicine toothpaste.
Comparative example 1
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 3% of paniculate swallowwort extract, 25% of sorbitol, 5% of polyethylene glycol, 2% of sodium dodecyl sulfate, 0.1% of sodium lauroyl sarcosine, 1% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 10% of silicon dioxide, 5% of calcium hydrophosphate, 0.1% of sodium benzoate, 2% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B;
s2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the polyethylene glycol, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.096 MPa for 30min to obtain paste, and packaging to obtain aromatic Chinese herbal toothpaste.
Comparative example 2
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of paniculate swallowwort root extract, 3% of perilla stem extract, 25% of sorbitol, 5% of polyethylene glycol, 2% of sodium dodecyl sulfate, 0.1% of sodium lauroyl sarcosine, 1% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 10% of silicon dioxide, 5% of calcium hydrophosphate, 0.1% of sodium benzoate, 2% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C;
s2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into the solution B, stirring uniformly, adding sodium benzoate, and mixing uniformly to obtain a component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding peppermint essence and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.096 MPa for 30min to obtain paste, and packaging to obtain aromatic Chinese herbal toothpaste.
Comparative example 3
The aromatic Chinese herbal medicine toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 3% of perilla stem extract, 25% of sorbitol, 5% of polyethylene glycol, 2% of sodium dodecyl sulfate, 0.1% of sodium lauroyl sarcosine, 1% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 10% of silicon dioxide, 5% of calcium hydrophosphate, 0.1% of sodium benzoate, 2% of mint essence and the balance of water.
The preparation method of the aromatic Chinese herbal medicine toothpaste comprises the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C;
s2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol and saccharin sodium into water, stirring, adding sodium benzoate, and mixing to obtain component B;
s3, putting the component A and the component B into paste preparation equipment, fully mixing and uniformly stirring, then adding the solution A and the solution C, and continuously and uniformly stirring to obtain paste;
and S4, grinding the paste of the step S3 uniformly by a grinder, and grinding the too coarse and too hard particles to make the paste fine, uniform and stable. Then vacuum degassing, degassing and stirring under vacuum degree of-0.096 MPa for 30min to obtain paste, and packaging to obtain aromatic Chinese herbal toothpaste.
The specific composition comparisons of inventive examples 1-5 and comparative examples 1-3 and adjuvant adjuvants are shown in Table 1.
Table 1 specific composition comparison of examples 1 to 5 and comparative examples 1 to 3 and auxiliary materials
1. Stability test
The stability test was performed on the herbal toothpastes of examples 1 to 5 of the present invention, and the specific procedure was as follows:
the herbal toothpastes of examples 1 to 5 of the present invention were stored at 1, 5 and 20 ℃ respectively, and whether the stability of the toothpaste paste was changed was observed.
From the above experiments, it is apparent that the Chinese herbal toothpastes of examples 1 to 5 were stored at 1, 5 and 20 ℃ for 15 days, respectively, the stability of the paste was not changed, and the paste was coated on the toothbrush, and the adhesion to the toothbrush was not significantly different.
2. Antibacterial test
In order to illustrate the antibacterial and anti-inflammatory effects of the herbal toothpaste of the embodiment of the present invention, the following antibacterial test was performed.
Staphylococcus aureus is a representative gram-positive bacterium, a common food-borne pathogenic bacterium, and is widely found in natural environments. The eupatorium extract, the paniculate swallowwort root extract and the perilla stem extract are combined according to a certain proportion for the following test, wherein the proportion of the Chinese herbal medicine extract in the toothpaste is equal.
The sterilization experiment is carried out on staphylococcus aureus by adopting toothpaste with equal quality, and the experiment time is 5min. The test results are shown in Table 2.
Table 2 results of sterilization tests of example 2 and comparative examples 1 to 3
| Blank control | Comparative example 1 | Comparative example 2 | Comparative example 3 | Example 2 | |
| Initial colony count (number) | 1.76×10 5 | 1.34×10 5 | 1.68×10 5 | 2.32×10 5 | 1.89×10 5 |
| Recovery of colony count | 7.46×10 4 | 1.16×10 4 | 2.14×10 4 | 2.92×10 4 | 1.32×10 3 |
| Sterilization rate (%) | 57.6 | 91.3 | 87.3 | 87.4 | 99.3 |
As is clear from the results in table 2, the combination effect of the eupatorium extract and the paniculate swallowwort extract can achieve a good bactericidal effect on staphylococcus aureus, but compared with the combination effect of comparative examples 1 to 3, the Chinese herbal medicine toothpaste of example 2 of the invention can achieve a more obvious bactericidal effect and achieve a bactericidal rate of 99.3% by the combination of the eupatorium extract, the paniculate swallowwort extract and the perilla stem extract. Therefore, the invention can inhibit pathogenic bacteria in oral cavity by the synergistic effect of the eupatorium extract, the paniculate swallowwort root extract and the perilla stem extract, and has the effects of refreshing breath, diminishing inflammation and easing pain.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (4)
1. The aromatic Chinese herbal medicine toothpaste is characterized by comprising the following components in percentage by mass: 1 to 5 percent of eupatorium extract, 1 to 5 percent of paniculate swallowwort root extract, 1 to 5 percent of perilla stem extract, 5 to 25 percent of sorbitol, 1 to 10 percent of polyethylene glycol, 0.5 to 3 percent of sodium dodecyl sulfate, 0.1 to 2 percent of sodium lauroyl sarcosinate, 0.5 to 2 percent of sodium carboxymethyl cellulose, 0.1 to 0.5 percent of saccharin sodium, 5 to 25 percent of silicon dioxide, 0.1 to 5 percent of calcium hydrophosphate, 0.01 to 0.1 percent of sodium benzoate, 0.1 to 2 percent of mint essence and the balance of water; wherein the herba Eupatorii extract, radix Cynanchi Paniculati extract, and caulis Perillae extract are water extracts.
2. The aromatic herbal toothpaste according to claim 1, wherein the aromatic herbal toothpaste is prepared from the following components in percentage by mass: 5% of eupatorium extract, 5% of paniculate swallowwort root extract, 3% of perilla stem extract, 20% of sorbitol, 8% of polyethylene glycol, 1% of sodium dodecyl sulfate, 1% of sodium lauroyl sarcosinate, 0.5% of sodium carboxymethyl cellulose, 0.1% of saccharin sodium, 5% of silicon dioxide, 2% of calcium hydrophosphate, 0.05% of sodium benzoate, 2% of mint essence and the balance of water.
3. The method for preparing the aromatic Chinese herbal medicine toothpaste according to any one of claims 1 to 2, comprising the following steps:
s1, weighing all raw materials according to a formula; dissolving herba Eupatorii extract in herba Menthae essence to obtain solution A; dissolving radix Cynanchi Paniculati extract in water to obtain solution B; dissolving the perilla stem extract in polyethylene glycol to obtain a solution C;
s2, mixing calcium hydrophosphate, silicon dioxide, sodium dodecyl sulfate, sodium lauroyl sarcosinate and sodium carboxymethyl cellulose to obtain a component A;
adding sorbitol, saccharin sodium and sodium benzoate into the solution B, and uniformly mixing to obtain a component B;
s3, mixing and stirring the component A and the component B uniformly, then adding the solution A and the solution C, and continuing to stir uniformly to obtain paste;
and S4, grinding the paste of the step S3 uniformly, and then carrying out vacuum degassing to obtain the aromatic Chinese herbal medicine toothpaste.
4. The method for preparing a fragrant Chinese herbal medicine toothpaste according to claim 3, wherein in S4, the vacuum degassing is performed under a vacuum degree of-0.15 to-0.09 MPa for 10-30 min.
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| JP2018203628A (en) * | 2017-05-30 | 2018-12-27 | 一丸ファルコス株式会社 | Cosmetic composition or food and drink composition |
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