CN110604810A - Hydrolyzed collagen gel for gynecology and preparation method thereof - Google Patents
Hydrolyzed collagen gel for gynecology and preparation method thereof Download PDFInfo
- Publication number
- CN110604810A CN110604810A CN201910881982.2A CN201910881982A CN110604810A CN 110604810 A CN110604810 A CN 110604810A CN 201910881982 A CN201910881982 A CN 201910881982A CN 110604810 A CN110604810 A CN 110604810A
- Authority
- CN
- China
- Prior art keywords
- parts
- hydrolyzed collagen
- gynecological
- collagen gel
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000512 collagen gel Substances 0.000 title claims abstract description 66
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000002994 raw material Substances 0.000 claims abstract description 34
- 241001116389 Aloe Species 0.000 claims abstract description 31
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 31
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 claims abstract description 28
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 claims abstract description 28
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 28
- 229930014456 matrine Natural products 0.000 claims abstract description 28
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 28
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 28
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 27
- 102000008186 Collagen Human genes 0.000 claims abstract description 24
- 108010035532 Collagen Proteins 0.000 claims abstract description 24
- 229920001436 collagen Polymers 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 24
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 23
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 22
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 22
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 22
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 22
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 21
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 21
- 239000011709 vitamin E Substances 0.000 claims abstract description 21
- 229940046009 vitamin E Drugs 0.000 claims abstract description 21
- 229940037003 alum Drugs 0.000 claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 14
- 230000001954 sterilising effect Effects 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 60
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 239000008213 purified water Substances 0.000 claims description 31
- 238000001914 filtration Methods 0.000 claims description 28
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 24
- 229920002125 Sokalan® Polymers 0.000 claims description 24
- 229960001631 carbomer Drugs 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 23
- 239000000706 filtrate Substances 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 20
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 19
- 229940116229 borneol Drugs 0.000 claims description 19
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 19
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 19
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 18
- 235000011187 glycerol Nutrition 0.000 claims description 18
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 18
- 235000019477 peppermint oil Nutrition 0.000 claims description 18
- 239000012141 concentrate Substances 0.000 claims description 15
- 239000011159 matrix material Substances 0.000 claims description 14
- 239000011259 mixed solution Substances 0.000 claims description 14
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 13
- 229940041616 menthol Drugs 0.000 claims description 13
- 238000002791 soaking Methods 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 14
- 206010061218 Inflammation Diseases 0.000 abstract description 8
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 230000008439 repair process Effects 0.000 abstract description 6
- 241000700605 Viruses Species 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 230000029142 excretion Effects 0.000 abstract description 4
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- -1 Alumen Substances 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000003993 interaction Effects 0.000 abstract description 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 9
- 210000004877 mucosa Anatomy 0.000 description 9
- 230000003749 cleanliness Effects 0.000 description 6
- 230000007794 irritation Effects 0.000 description 6
- 241000193830 Bacillus <bacterium> Species 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000004177 elastic tissue Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 241000246044 Sophora flavescens Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 206010047786 Vulvovaginal discomfort Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 210000000695 crystalline len Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 210000004994 reproductive system Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 239000006159 Sabouraud's agar Substances 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241001052560 Thallis Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229940065181 bacillus anthracis Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036983 biotransformation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229930015582 oxymatrine Natural products 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 125000002640 tocopherol group Chemical group 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a gynecological hydrolyzed collagen gel and a preparation method thereof, wherein the gynecological hydrolyzed collagen gel comprises the following raw materials: hydrolyzed collagen powder, Alumen, vitamin E, Borneolum Syntheticum, Aloe, sodium hyaluronate, ethylparaben, polyhexamethylene biguanide, matrine, Mentholum, oleum Menthae Dementholatum, and adjuvants. The invention has the beneficial effects that: the gynecological hydrolyzed collagen gel can directly act on the affected part with gynecological inflammation, the contained hydrolyzed collagen powder can improve the living environment of cells and restore the elasticity of skin, and the aloe can enable cell tissues to be rich in elasticity and enhance the capability of defending germs and viruses; sodium hyaluronate can promote the supply of skin nutrition and the excretion of waste; the alum, the polyhexamethylene biguanide and the matrine have strong sterilization and bacteriostasis effects, namely, the interaction of the raw materials of the gel can improve the living environment of vaginal cells and repair damaged cells, and the gel has strong sterilization and bacteriostasis effects, thereby fundamentally achieving the effect of preventing gynecological diseases.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a gynecological hydrolyzed collagen gel and a preparation method thereof.
Background
Gynecological diseases become common diseases which afflict modern women and seriously affect the physical and mental health of the women. At present, the clinical treatment of gynecological inflammation mainly adopts large-dose antibiotics, and sometimes adopts the combined use of a plurality of antibiotics, so that the clinical symptoms of antibiotic side effects such as drug resistance, complications and the like become more and more obvious, and the harm to patients is larger. In addition, the oral anti-inflammatory drug for treating gynecological inflammation has long treatment time and poor treatment effect, has certain side effect on liver and kidney functions, and cannot achieve the aim of thoroughly curing gynecological inflammation.
Disclosure of Invention
The invention aims to provide a gynecological hydrolyzed collagen gel which can directly act on an affected part, repair damaged vaginal mucosa, enhance the capabilities of detoxifying, sterilizing and excreting of a reproductive system, activate vaginal cell activity, repair damaged vaginal fibers and make female private parts compact and elastic, and a preparation method thereof.
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 40-60 parts of hydrolyzed collagen powder, 10-30 parts of alum, 4-6 parts of vitamin E, 1-3 parts of borneol, 20-40 parts of aloe, 8-12 parts of sodium hyaluronate, 2-4 parts of ethylparaben, 0.2-0.3 part of polyhexamethylene biguanide, 10-30 parts of matrine, 4-6 parts of menthol, 1-3 parts of peppermint oil and 900 parts of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 10-30 parts of carbomer, 5-15 parts of glycerol, 5-15 parts of triethanolamine and 880 parts of purified water.
Further, the hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 45-55 parts of hydrolyzed collagen powder, 15-25 parts of alum, 4-5 parts of vitamin E, 1.5-2.5 parts of borneol, 25-35 parts of aloe, 9-11 parts of sodium hyaluronate, 2.5-3.5 parts of ethylparaben, 0.22-0.25 part of polyhexamethylene biguanide, 15-25 parts of matrine, 4.5-5.5 parts of menthol, 1.5-2.5 parts of peppermint oil and 880 parts of auxiliary materials 820-;
the auxiliary materials comprise the following raw materials in parts by weight: 15-25 parts of carbomer, 8-12 parts of glycerol, 8-12 parts of triethanolamine and 830 parts of purified water.
Further, the hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 50 parts of hydrolyzed collagen powder, 20 parts of alum, 5 parts of vitamin E, 2 parts of borneol, 30 parts of aloe, 10 parts of sodium hyaluronate, 3 parts of ethylparaben, 0.25 part of polyhexamethylene biguanide, 20 parts of matrine, 5 parts of menthol, 2 parts of peppermint oil and 852.75 parts of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 20 parts of carbomer, 10 parts of glycerol, 10 parts of triethanolamine and 812.75 parts of purified water.
The hydrolyzed collagen powder is a natural biological product, is rich in various bioactive substances such as polypeptide and the like necessary for human metabolism, particularly rich in hydroxyproline (> 12%) necessary for cartilage, skin and hair metabolism, is the main material basis of connective tissues, is a water-containing natural moisturizing factor, has strong permeability, can keep the integrity of moisture and fiber structures of horny layers, improves the living environment of skin cells, promotes the metabolism of skin tissues and enhances the blood circulation. Strong water locking is performed, so that the skin is durably moist, glossy and delicate, the local collapse can be filled, the looseness is improved, the broken and aged elastic fiber net is repaired, and the skin is elastically recovered, flexible and full; the cell adhesion is more compact, the metabolism speed is accelerated, the exfoliation of dead skin is promoted, the melanin deposition is prevented, the free radicals in the body are removed, the multi-path oxidation resistance is realized, the immunity is improved, and the aging is slowed down.
The alum is a mineral traditional Chinese medicine, has the advantages of good taste and sour and astringent properties, has the effects of resisting bacteria and astringing, has the effects of detoxifying and killing insects when being externally used, has the inhibiting effect on staphylococcus aureus and proteus, and also has obvious inhibiting effect on escherichia coli, pseudomonas aeruginosa, bacillus anthracis, dysentery bacillus, typhoid bacillus, bacillus paratyphi, proteus bacillus, staphylococcus, candida albicans and the like; has strong antibacterial effect on green streptococcus, hemolytic streptococcus, pneumococcus and diphtheria bacillus.
Vitamin E is a fat-soluble vitamin whose hydrolysate is tocopherol, one of the most important antioxidants. Vitamin E can promote reproduction, promote secretion of sex hormone, increase sperm motility and number of male, increase female estrogen concentration, improve fertility, and prevent abortion. Can inhibit lipid peroxide reaction in eye lens, dilate peripheral blood vessel, improve blood circulation, and prevent myopia occurrence and development.
Borneol, named as borneol, borneol and the like, is a crystal extracted from a resin and volatile oil processed product of borneol of a borneol family plant, and is similar to pure dextroborneol. It has fragrant smell and cool taste. The borneol has the functions of bacteriostasis and anti-inflammation, is easy to absorb in mucous membrane and subcutaneous tissue, has light stimulation to sensory nerve when being applied to local parts, has the functions of relieving pain and mild antisepsis, and can be used for treating neuralgia.
The mucus in aloe is an important component for preventing cell aging and treating chronic allergy, and can make cell tissue elastic, and if the liquid is insufficient, muscle and mucosa lose elasticity and become rigid and aged, and cells gradually weaken and lose the ability of defending germs and viruses.
Sodium hyaluronate is an inherent component in human body, is a glucan aldehyde acid and widely exists in tissues such as placenta, amniotic fluid, crystalline lens, articular cartilage, skin dermis and the like; the sodium hyaluronate is a biological substance inherent to the skin, and the exogenous sodium hyaluronate is a supplement for the endogenous sodium hyaluronate of the skin. Sodium hyaluronate with small mass can penetrate into epidermis layer of skin, promote supply of skin nutrition and excretion of waste, thereby preventing skin aging, promoting proliferation and differentiation of epidermal cells, scavenging oxygen free radicals, preventing and promoting skin regeneration of injured part, and caring skin.
The ethylparaben is white crystal, and is mainly used as antiseptic for food, cosmetics and medicine.
The polyhexamethylene biguanide has strong capability of killing bacteria, high action speed, stable property, can be used at normal temperature, has no side effect after long-term bacteriostasis, adsorbs bacteria and viruses which are usually electronegative, can enter a cell membrane, inhibits the apoptosis of thalli caused by the synthesis of intramembrane liposome, and achieves the optimal bactericidal effect.
The matrine is prepared from dried root, plant and fruit of Sophora flavescens ait of Leguminosae by extracting with organic solvent such as ethanol, and is alkaloid. Generally, it is matrine, and the content of matrine and oxymatrine is the highest. The sophora flavescens is used as a medicinal plant and has the main functions of clearing heat, promoting urination, killing insects, clearing damp and the like; has antibacterial and anti-inflammatory effects, and has different inhibiting effects on fungal infection of skin and vagina, such as matrine suppository for treating mycotic vaginitis.
Mentholum is extracted from leaf and stem of herba Menthae, and can be used as irritation in medicine, and has effects of refreshing, relieving itching, relieving inflammation, promoting blood circulation, and relieving swelling.
The oleum Menthae Dementholatum is prepared by steam distilling fresh stems and leaves of herba Menthae of Labiatae, and has yield of 0.3% -0.6%. Is natural essential oil, has strong mint fragrance, and can dredge heat and detoxify, diminish inflammation and relieve itching, prevent decay and remove fishy smell.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol, and stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water, filtering to remove residue, concentrating the filtrate, adding ethanol into the concentrate, stirring, mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking to obtain gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, and mixing and stirring uniformly to obtain the gynecological hydrolyzed collagen gel.
Further, in the step (1), the ratio of the added ethanol to the total weight of the matrine, the menthol, the ethylparaben and the borneol is 4-5: 3.
Further, in the step (2), adding aloe and alum into water for first decoction, and filtering to obtain first filtrate after the decoction is finished; adding water into the filter residue obtained by filtering for second decoction, and filtering to obtain a second filtrate after the decoction is finished; mixing the filtrates, and concentrating to obtain concentrate.
Further, the resulting concentrate has a density of 1.10g/ml to 1.20 g/ml.
Further, during the first decoction: the ratio of water to the total weight of Aloe and Alumen is 6-8:1, and the first decoction time is 1-3 hr; during the second decoction: the weight ratio of water to residue is 4-6:1, and the time for the second decoction is 1-2 hr.
Further, in the step (3), the weight ratio of the added purified water to the carbomer is 10-20: 1, the soaking time is 3-4 h.
Further, in the step (4), after the raw materials are mixed and stirred uniformly, the hydrolyzed collagen gel for gynecology is obtained through microwave sterilization.
The application method of the hydrolyzed collagen gel for gynecology provided by the invention comprises the following steps: cleaning vulva, lying on back, extruding the gel, applying to vaginal discomfort (pushing the gel into vaginal discomfort with the aid of booster), lying on back for 3 min, 1-2 times daily, and 3-5g each time.
The invention has the beneficial effects that: the gynecological hydrolyzed collagen gel can be directly applied to affected parts with gynecological inflammation, the contained hydrolyzed collagen powder can improve the living environment of cells and restore the elasticity of skin, and the aloe can enable cell tissues to be rich in elasticity and enhance the capability of defending germs and viruses; sodium hyaluronate can promote the supply of skin nutrition and the excretion of waste; the alum, the polyhexamethylene biguanide and the matrine have strong sterilization and bacteriostasis effects, namely, the interaction of the raw materials of the gel can improve the living environment of vaginal cells and repair damaged cells, and the gel has strong sterilization and bacteriostasis effects, can fundamentally regulate endocrine and promote hormone balance, and fundamentally achieves the effect of preventing gynecological diseases.
In addition, the gynecological hydrolyzed collagen gel can repair damaged vaginal mucosa and enhance the capabilities of detoxification, sterilization, decomposition and excretion of a reproductive system; meanwhile, the vaginal suppository can activate the activity of vaginal cells, repair damaged elastic fibers of the vagina, recover the elasticity of the damaged elastic fibers, recover the vaginal holding power and make the female private parts compact and elastic.
Detailed Description
Example 1
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 40g of hydrolyzed collagen powder, 10g of alum, 4g of vitamin E, 1g of borneol, 20g of aloe, 8g of sodium hyaluronate, 2g of ethylparaben, 0.2g of polyhexamethylene biguanide, 10g of matrine, 4g of menthol, 1g of peppermint oil and 800g of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 10g of carbomer, 5g of glycerol, 5g of triethanolamine and 740g of purified water.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol, and stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water, filtering to remove residue, concentrating the filtrate, adding ethanol into the concentrate, stirring, mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking to obtain gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, and mixing and stirring uniformly to obtain the gynecological hydrolyzed collagen gel.
The cleanliness of the production plant area of the hydrolyzed collagen gel for gynecology in the embodiment is as follows: on the order of 30 ten thousand.
Example 2
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 45g of hydrolyzed collagen powder, 15g of alum, 4g of vitamin E, 1.5g of borneol, 25g of aloe, 9g of sodium hyaluronate, 2.5g of ethylparaben, 0.22g of polyhexamethylene biguanide, 15g of matrine, 4.5g of menthol, 1.5g of peppermint oil and 820g of auxiliary material;
the auxiliary materials comprise the following raw materials in parts by weight: 15g of carbomer, 8g of glycerol, 8g of triethanolamine and 789g of purified water.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol at a ratio of 4:3, stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water at a ratio of water to Aloe and Alumen of 6:1 for 1 hr, and filtering to obtain first filtrate; adding water into the filter residue obtained by filtering, decocting for 1h, wherein the weight ratio of the water to the filter residue is 4:1, and filtering to obtain a second filtrate after the decoction is finished; mixing the two filtrates, concentrating to obtain concentrate with density of 1.10g/ml, adding ethanol into the concentrate, stirring and mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking for 3h, wherein the weight ratio of the added purified water to the carbomer is 20: 1, obtaining a gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, mixing and stirring uniformly, and performing microwave sterilization to obtain the gynecological hydrolyzed collagen gel.
The cleanliness of the production plant area of the hydrolyzed collagen gel for gynecology in the embodiment is as follows: on the order of 30 ten thousand.
Example 3
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 50g of hydrolyzed collagen powder, 20g of alum, 5g of vitamin E, 2g of borneol, 30g of aloe, 10g of sodium hyaluronate, 3g of ethylparaben, 0.25g of polyhexamethylene biguanide, 20g of matrine, 5g of menthol, 2g of peppermint oil and 852.75g of auxiliary material;
the auxiliary materials comprise the following raw materials in parts by weight: 20g of carbomer, 10g of glycerol, 10g of triethanolamine and 812.75g of purified water.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol at a ratio of 4.5:3, stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water at a ratio of water to Aloe and Alumen of 6.5:1 for 1.5 hr, and filtering to obtain first filtrate; adding water into the filter residue obtained by filtering, decocting for 1.5h, wherein the weight ratio of the water to the filter residue is 4.5:1, and filtering to obtain a second filtrate after the decoction is finished; mixing the two filtrates, concentrating to obtain concentrate with density of 1.10g/ml, adding ethanol into the concentrate, stirring, mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking for 3.5h, wherein the weight ratio of the added purified water to the carbomer is 15: 1, obtaining a gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, mixing and stirring uniformly, and performing microwave sterilization to obtain the gynecological hydrolyzed collagen gel.
The cleanliness of the production plant area of the hydrolyzed collagen gel for gynecology in the embodiment is as follows: on the order of 30 ten thousand.
Example 4
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 55g of hydrolyzed collagen powder, 25g of alum, 5g of vitamin E, 2.5g of borneol, 35g of aloe, 11g of sodium hyaluronate, 3.5g of ethylparaben, 0.25g of polyhexamethylene biguanide, 25g of matrine, 5.5g of menthol, 2.5g of peppermint oil and 880g of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 25g of carbomer, 12g of glycerol, 12g of triethanolamine and 831g of purified water.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol at a ratio of 4.8:3, stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water at a ratio of water to Aloe and Alumen of 7:1 for 2.5 hr, and filtering to obtain first filtrate; adding water into the filter residue obtained by filtering, decocting for 1.6h, wherein the weight ratio of the water to the filter residue is 5:1, and filtering to obtain a second filtrate after the decoction is finished; mixing the two filtrates, concentrating to obtain concentrate with density of 1.15g/ml, adding ethanol into the concentrate, stirring, mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking for 3.5h, wherein the weight ratio of the added purified water to the carbomer is 12: 1, obtaining a gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, mixing and stirring uniformly, and performing microwave sterilization to obtain the gynecological hydrolyzed collagen gel.
The cleanliness of the production plant area of the hydrolyzed collagen gel for gynecology in the embodiment is as follows: on the order of 30 ten thousand.
Example 5
The hydrolyzed collagen gel for gynecology comprises the following raw materials in parts by weight: 60g of hydrolyzed collagen powder, 30g of alum, 6g of vitamin E, 3g of borneol, 40g of aloe, 12g of sodium hyaluronate, 4g of ethylparaben, 0.3g of polyhexamethylene biguanide, 30g of matrine, 6g of menthol, 3g of peppermint oil and 900g of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 30g of carbomer, 15g of glycerol, 15g of triethanolamine and 840g of purified water.
The preparation method of the hydrolyzed collagen gel for gynecology comprises the following steps:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol at a ratio of 5:3, stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water at a ratio of water to Aloe and Alumen of 8:1 for 3 hr, and filtering to obtain first filtrate; adding water into the filter residue obtained by filtering, decocting for 2h, wherein the weight ratio of the water to the filter residue is 6:1, and filtering to obtain a second filtrate after the decoction is finished; mixing the two filtrates, concentrating to obtain concentrate with density of 1.20g/ml, adding ethanol into the concentrate, stirring and mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking for 4h, wherein the weight ratio of the added purified water to the carbomer is 10: 1, obtaining a gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, mixing and stirring uniformly, and performing microwave sterilization to obtain the gynecological hydrolyzed collagen gel.
The cleanliness of the production plant area of the hydrolyzed collagen gel for gynecology in the embodiment is as follows: on the order of 30 ten thousand.
Comparative example 1
The gynecological hydrolyzed collagen gel in the comparative example 1 is prepared from raw materials which do not contain hydrolyzed collagen powder and sodium hyaluronate, and the rest raw materials and the preparation method are the same as those in the example 3.
Comparative example 2
Comparative example 2 the hydrolyzed collagen gel for gynecology, which comprises the raw materials without polyhexamethylene biguanide and matrine, and the rest raw materials and the preparation method are the same as those contained in example 3.
Comparative example 3
The gynecological hydrolyzed collagen gel of comparative example 3 was prepared without aloe and alum, and the remaining raw materials and preparation methods were the same as those of example 3.
The cleanliness of the production plant of the gynecological hydrolyzed collagen gel in comparative examples 1 to 3 is as follows: on the order of 30 ten thousand. The study on the bacteriostasis of the gynecological hydrolyzed collagen gel prepared in the embodiments 1 to 5 of the invention and the gynecological hydrolyzed collagen gel prepared in the comparative examples 1 to 3 is as follows:
first, bacteriostasis test
1. Experimental equipment
(1) Experimental strains: culturing 9 generations of Escherichia coli, Candida albicans and Staphylococcus aureus, all provided by China center for culture Collection;
(2) the common nutrient agar culture medium and the Sabouraud's agar culture medium are provided by Beijing road bridge technology, Inc.;
(3)0.03mol/L phosphate buffer solution;
(4) carrier: filter paper (2.0cm multiplied by 3.0cm), sterile scale suction pipe, sterile plate, sterile test tube and constant temperature incubator.
2. Sample (I)
(1) The gynecological hydrolyzed collagen gel of the embodiments 1 to 5 of the invention and the gynecological hydrolyzed collagen gel of the comparative examples 1 to 3;
(2) sample processing
Respectively weighing 5g of the samples, respectively putting the samples into a sterile mortar for grinding, crushing, and respectively putting the ground samples into a sterile plate for directly carrying out an antibacterial test.
3. Test method
(1) The examination is carried out according to GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C4, Disinfection technical Specification 2002 edition 2.1.8
(2) The bacteriostatic test is a carrier test. The test temperature is 20 +/-1 ℃, the action time is 5min, the test is repeated three times, and the average value is calculated.
4. The inspection mechanism comprises: shaanxi New era biotransformation detection Co., Ltd
The gynecological hydrolyzed collagen gel prepared in examples 1 to 5 and the gynecological hydrolyzed collagen gel prepared in comparative examples 1 to 3 have bacteriostatic effects on escherichia coli, candida albicans and staphylococcus aureus, as shown in table 1:
TABLE 1
| Antibacterial rate of Escherichia coli | Bacteriostasis rate of candida albicans | Staphylococcus aureus bacteriostasis rate | |
| Example 1 | 98％ | 97％ | 98％ |
| Example 2 | 97％ | 98％ | 96％ |
| Example 3 | 96％ | 98％ | 96％ |
| Example 4 | 96％ | 95％ | 98％ |
| Example 5 | 98％ | 96％ | 96％ |
| Comparative example 1 | 85％ | 88％ | 80％ |
| Comparative example 2 | 68％ | 60％ | 65％ |
| Comparative example 3 | 79％ | 80％ | 78％ |
As can be seen from Table 1, the gynecological hydrolyzed collagen gel prepared in the embodiments 1-5 has a bacteriostasis rate of over 95% for Escherichia coli, Candida albicans and Staphylococcus aureus; the gynecological hydrolyzed collagen gel in the comparative example 1 does not contain hydrolyzed collagen powder and sodium hyaluronate, and cannot sufficiently improve the living environment of cells, so that the bacteriostatic rate is reduced; the bacteriostatic effects of the hydrolyzed collagen gel for gynecology in the comparative examples 2 and 3 are lower than 90%, namely, the hydrolyzed collagen gel for gynecology in the invention achieves higher bacteriostatic performance through the mutual synergistic effect of the raw materials.
Second, vagina mucosa irritation test
1. The test substance: the hydrolyzed collagen gel for gynecology of the invention;
2. test animal
6 Japanese big ear white rabbits, female, 2.0-2.5kg in weight, primary animals, license numbers, were provided by the laboratory zoology center of the medical school of Xian traffic university: SCXK (shan) 2014-.
3. And (3) test environment: temperature: 22-25 ℃, relative humidity: 45 to 55 percent.
4. The inspection basis is as follows: the experiment was carried out by 2.3.5 method in 2002 edition "Disinfection technical Specification" of Ministry of public health.
5. Dose of test substance: 2 g/piece.
6. Test method
During the test, the animal is fixed in a supine position, 2 g/rabbit (the hydrolyzed collagen gel for gynecology of the invention) of the test object is injected into the tested rabbit through the vagina, and the animal is fixed in a supine position for 4 hours, so that the test object is fully contacted with the vaginal mucosa. After the experiment is finished, the animals are put back into cages for feeding, the tested rabbits are taken out for killing after 24 hours, the vaginal tissues are taken out, the phenomena of mucosa, secretion, blood vessel congestion, edema and the like are carefully observed, and if the pathological histology is changed, the pathological histology is checked.
7. Test results
According to the classification standard of the vaginal mucosa irritation reaction in 2002 edition of disinfection technical Specification of Ministry of health, the gynecological hydrolyzed collagen gel has no irritation to the vaginal mucosa irritation reaction of the rabbits, namely the gynecological hydrolyzed collagen gel has no irritation to the vaginal mucosa.
The present invention is not limited to the above-described preferred embodiments, and various other forms of the product can be obtained by anyone who has come within the teachings of the present invention, but any variation in the details thereof, which is the same as or similar to the claims of the present application, falls within the scope of the present invention.
Claims (10)
1. The hydrolyzed collagen gel for gynecology is characterized by comprising the following raw materials in parts by weight: 40-60 parts of hydrolyzed collagen powder, 10-30 parts of alum, 4-6 parts of vitamin E, 1-3 parts of borneol, 20-40 parts of aloe, 8-12 parts of sodium hyaluronate, 2-4 parts of ethylparaben, 0.2-0.3 part of polyhexamethylene biguanide, 10-30 parts of matrine, 4-6 parts of menthol, 1-3 parts of peppermint oil and 900 parts of auxiliary materials;
the auxiliary materials comprise the following raw materials in parts by weight: 10-30 parts of carbomer, 5-15 parts of glycerol, 5-15 parts of triethanolamine and 880 parts of purified water.
2. The gynecological hydrolyzed collagen gel according to claim 1, which comprises the following raw materials in parts by weight: 45-55 parts of hydrolyzed collagen powder, 15-25 parts of alum, 4-5 parts of vitamin E, 1.5-2.5 parts of borneol, 25-35 parts of aloe, 9-11 parts of sodium hyaluronate, 2.5-3.5 parts of ethylparaben, 0.22-0.25 part of polyhexamethylene biguanide, 15-25 parts of matrine, 4.5-5.5 parts of menthol, 1.5-2.5 parts of peppermint oil and 880 parts of auxiliary materials 820-;
the auxiliary materials comprise the following raw materials in parts by weight: 15-25 parts of carbomer, 8-12 parts of glycerol, 8-12 parts of triethanolamine and 830 parts of purified water.
3. The gynecological hydrolyzed collagen gel according to claim 1, which comprises the following raw materials in parts by weight: 50 parts of hydrolyzed collagen powder, 20 parts of alum, 5 parts of vitamin E, 2 parts of borneol, 30 parts of aloe, 10 parts of sodium hyaluronate, 3 parts of ethylparaben, 0.25 part of polyhexamethylene biguanide, 20 parts of matrine, 5 parts of menthol, 2 parts of peppermint oil and 852.75 parts of auxiliary material;
the auxiliary materials comprise the following raw materials in parts by weight: 20 parts of carbomer, 10 parts of glycerol, 10 parts of triethanolamine and 812.75 parts of purified water.
4. A process for the preparation of a gynaecological hydrolyzed collagen gel according to any one of claims 1 to 3, comprising the steps of:
(1) adding matrine, Mentholum, ethylparaben, and Borneolum Syntheticum into ethanol, and stirring to dissolve completely to obtain mixed solution;
(2) decocting Aloe and Alumen in water, filtering to remove residue, concentrating the filtrate, adding ethanol into the concentrate, stirring, mixing, standing, and filtering to obtain extract;
(3) adding purified water into carbomer, and soaking to obtain gel matrix;
(4) adding the mixed solution, the extract, the hydrolyzed collagen powder, the sodium hyaluronate, the vitamin E, the peppermint oil, the polyhexamethylene biguanide and the glycerin into the gel matrix, adding the purified water and the triethanolamine, and mixing and stirring uniformly to obtain the gynecological hydrolyzed collagen gel.
5. The method for preparing the gynecological hydrolyzed collagen gel according to claim 4, wherein in the step (1), the ratio of the amount of ethanol to the total weight of the matrine, the menthol, the ethylparaben and the borneol is 4-5: 3.
6. The method for preparing gynecological hydrolyzed collagen gel according to claim 4, wherein in the step (2), aloe and alum are added into water for the first decoction, and after the decoction is finished, the first filtrate is obtained by filtration; adding water into the filter residue obtained by filtering for second decoction, and filtering to obtain a second filtrate after the decoction is finished; mixing the filtrates, and concentrating to obtain concentrate.
7. The process for preparing the hydrolyzed collagen gel for gynecology according to claim 4, wherein the density of the obtained concentrate is 1.10g/ml to 1.20 g/ml.
8. The method for preparing the gynecological hydrolyzed collagen gel according to claim 6, wherein the first decoction is: the ratio of water to the total weight of Aloe and Alumen is 6-8:1, and the first decoction time is 1-3 hr; during the second decoction: the weight ratio of water to residue is 4-6:1, and the time for the second decoction is 1-2 hr.
9. The method for preparing the gynecological hydrolyzed collagen gel according to claim 4, wherein in the step (3), the weight ratio of the added purified water to the carbomer is 10-20: 1, the soaking time is 3-4 h.
10. The preparation method of the gynecological hydrolyzed collagen gel according to claim 4, wherein in the step (4), the gynecological hydrolyzed collagen gel is obtained by microwave sterilization after the raw materials are uniformly mixed and stirred.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910881982.2A CN110604810A (en) | 2019-09-18 | 2019-09-18 | Hydrolyzed collagen gel for gynecology and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910881982.2A CN110604810A (en) | 2019-09-18 | 2019-09-18 | Hydrolyzed collagen gel for gynecology and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110604810A true CN110604810A (en) | 2019-12-24 |
Family
ID=68891553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910881982.2A Pending CN110604810A (en) | 2019-09-18 | 2019-09-18 | Hydrolyzed collagen gel for gynecology and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110604810A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135292A (en) * | 2020-01-17 | 2020-05-12 | 赵丽 | Recombinant private collagen peptide nursing antibacterial gel and preparation method thereof |
| CN112618702A (en) * | 2020-12-29 | 2021-04-09 | 山东丽达生物科技集团有限公司 | Traditional Chinese medicine biological preparation for promoting health restoration of female genital tract and preparation method thereof |
| CN112807419A (en) * | 2020-09-28 | 2021-05-18 | 臻锦生物科技(武汉)有限公司 | Pharmaceutical composition, preparation method thereof, external medicine and application |
| CN113827733A (en) * | 2020-06-16 | 2021-12-24 | 深圳长久康联生物科技有限公司 | Cold compress gel, and use method and application thereof |
| EP4023214A1 (en) * | 2021-01-05 | 2022-07-06 | Justus-Liebig-Universität Gießen | Slow-release device for wound disinfection and its usage |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736474A (en) * | 2005-07-28 | 2006-02-22 | 凌沛学 | Reversible heat gelling aquatic pharmaceutical composition of a Chinese medicine and compound prescription thereof |
| CN101036763A (en) * | 2007-04-10 | 2007-09-19 | 王瑞祥 | Medicated vaginal suppository |
| CN101791319A (en) * | 2010-04-07 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Female pudendum nursing product |
| CN103432584A (en) * | 2013-08-14 | 2013-12-11 | 金红叶纸业集团有限公司 | Cooling and itching relieving composition and paper towel employing same |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
| CN107875264A (en) * | 2017-11-21 | 2018-04-06 | 佛山微赢电子商务有限公司 | A kind of privates nursing bacteriostatic gel and preparation method thereof |
-
2019
- 2019-09-18 CN CN201910881982.2A patent/CN110604810A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736474A (en) * | 2005-07-28 | 2006-02-22 | 凌沛学 | Reversible heat gelling aquatic pharmaceutical composition of a Chinese medicine and compound prescription thereof |
| CN101036763A (en) * | 2007-04-10 | 2007-09-19 | 王瑞祥 | Medicated vaginal suppository |
| CN101791319A (en) * | 2010-04-07 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Female pudendum nursing product |
| CN103432584A (en) * | 2013-08-14 | 2013-12-11 | 金红叶纸业集团有限公司 | Cooling and itching relieving composition and paper towel employing same |
| CN107661494A (en) * | 2017-11-20 | 2018-02-06 | 方晓东 | It is a kind of to be used for gynaecological imflammation, the Chinese medicine composition gel of koro and its production technology |
| CN107875264A (en) * | 2017-11-21 | 2018-04-06 | 佛山微赢电子商务有限公司 | A kind of privates nursing bacteriostatic gel and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会著: "《中华人民共和国药典临床用药须知 中药饮片卷 2015年版》", 30 September 2017, 中国医药科技出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135292A (en) * | 2020-01-17 | 2020-05-12 | 赵丽 | Recombinant private collagen peptide nursing antibacterial gel and preparation method thereof |
| CN113827733A (en) * | 2020-06-16 | 2021-12-24 | 深圳长久康联生物科技有限公司 | Cold compress gel, and use method and application thereof |
| CN112807419A (en) * | 2020-09-28 | 2021-05-18 | 臻锦生物科技(武汉)有限公司 | Pharmaceutical composition, preparation method thereof, external medicine and application |
| CN112618702A (en) * | 2020-12-29 | 2021-04-09 | 山东丽达生物科技集团有限公司 | Traditional Chinese medicine biological preparation for promoting health restoration of female genital tract and preparation method thereof |
| EP4023214A1 (en) * | 2021-01-05 | 2022-07-06 | Justus-Liebig-Universität Gießen | Slow-release device for wound disinfection and its usage |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110604810A (en) | Hydrolyzed collagen gel for gynecology and preparation method thereof | |
| CN110464811A (en) | A kind of gynaecology's foam antibacterial liquid and preparation method thereof | |
| CN107802825A (en) | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa | |
| CN108096396A (en) | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa | |
| CN113057930A (en) | Mite-removing face cream containing rosemary and preparation method thereof | |
| CN113081928A (en) | Plant bacteriostatic gel and preparation method and application thereof | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN108524601A (en) | A kind of vaginal jellies and preparation method thereof containing pleiotrophic factor | |
| CN110613839A (en) | Chinese medicinal biological preparation for acting on female reproductive system and preparation method thereof | |
| CN111759885A (en) | Sophora flavescens composition, sophora flavescens gel and preparation method thereof | |
| CN109010526A (en) | One kind is for the antibacterial clean Traditional Chinese medicine gel composition of maintenance of vaginal mucosa | |
| CN111297961A (en) | Dong medicine for promoting wound healing | |
| CN104258455B (en) | A kind of medical bio antiseptic dressing and preparation method thereof | |
| JP2009269904A (en) | Herbal medicinal composition for curing external wound and bedsore and method of manufacturing medicine from the composition | |
| CN110354224A (en) | A kind of Traditional Chinese medicine gel composition antibacterial for vaginal mucosa, antipruritic, taste of dispelling | |
| CN109010529A (en) | A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing | |
| CN112245325A (en) | Health-care antibacterial gel and preparation method thereof | |
| CN112294886A (en) | Foam type lavender antibacterial lotion and preparation method thereof | |
| CN111658564A (en) | Gynecological vulva foam lotion and preparation method thereof | |
| CN116492397A (en) | Preparation for improving cow breeding performance, preparation method thereof and method for improving cow breeding performance | |
| CN110507748A (en) | A kind of milk cow hoof bath foam and preparation method thereof | |
| CN103432049B (en) | Composition with deodorization function | |
| CN113616774B (en) | Antibacterial composition containing plant stem cells, maintenance antibacterial liquid and preparation method thereof | |
| CN107551090A (en) | One kind, which is nourished, repairs gel | |
| CN108403570A (en) | There are the body condensation and preparation method of improvement to pruitus caused by eczema |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191224 |
|
| RJ01 | Rejection of invention patent application after publication |